Eige Medical Technology

Semi-Robotic Aid in Targeting Prostate Suspicious Lesions Use of mpMRI for Early Detection of Clinically Signi cant Prostate Cancer proprietarywww.eigen.com

Complete Solution for Accurate Targeted Prostate BiopsyNo Disposables No Additional Software or Hardware Required Electronic & Mechanical TrackingSemi-Automatic Patient Motion Compensation

1 1mpMRI data is transferred to ProFuse (typically through a PACS server )Radiologist annotates suspicious regions on the patient’s mpMRI usingthe advanced visualization tools of ProFuseThis data is exported to Artemis via cloud/network or CD/DVD 1-CAD Functionality of ProFuse Under FDA Consideration (ProFuse CAD)

Prostate is outlined on MRI (segmented) & targets are identi ed (top right images)Yellow, Red, and Blue lesions are marked and classi ed based on PI-RADS scoring ProFuse Automated tools con rms the suspicious level for targeting

Artemis is a 3D Semi-Robotic Prostate Navigation SystemUsing Artemis, the Urologist registers the preoperative MRI and intraoperative ultrasoundimages which helps map the suspicious areas of the prostatefrom MRI to ultrasound. Artemis then allows theUrologist to navigate to the identi ed areas forbiopsy. The sampled targets are saved tokeep a record of the biopsied regions.ProFuse Bx Provides Automatic, Fast, Rigid & Elastic Image Fusion We bring con dence & trust in the Fusion Technology and Targetd Biopsy

Quick, e cient procedure using Artemis will provide anaccurate lesion targeting & template-guided biopsyEasy clinical work ow is ideal for Urologists, Radiologists,& Radiation OncologistsBiopsy cores & visualization of biopsy needle trackingare recorded for target veri cationComprehensive Biopsy Report withPI-RADS classi cation & Pathology resultExceptional tool for treatment planning

Systemic Prostate Biopsy• Blind procedure – ‘poke and hope’• Often misses anterior lesions (Patel AR et al. Curr Opin Urol 2009; 19:232)mpMRI Approach•Integrated interpretation of conventional & multiple functional techniques•Comparison of 3 protocols in 83 pts: (Tanimoto A, JMRJ 2007)

Clinical Results Using Artemis and ProFuse 100 90% 80 Gleason > 7C 70A 60 CaPN 50#CREF! 40#EREF! 30R#REF!#REF!D#RxEF!#REF! 20 10 0 Image Grade # Patients 19 14 61 61 16 #Any CaP 6 6 29 34 15 # Gleaso > 7 Cap 3 1 9 14 794% of men with image grade 5 were found to have Pca



Improve Clinical Performance:Reduce # of Bx cores, potential reduction in rate of infection2 Reduce over-diagnosis of low-grade tumors Access previous recorded biopsies and cores Integrate pathology report to MRI lesions Multi-modality image fusion for treatment planningE cient Work ow:Access PACS Easy Network connectivity Review biopsy results with historic PET and CTFinancial Bene ts - ROI:Reduce unnecessary biopsy, Reduce unnecessary biopsy, Detect signi cant cancer early, potential treatment plan Multi discipline approach to deliver quality of care 2 - Based on Published Studies available upon request. Inquiries may be submitted to “[email protected]”

Eigen brings innovation to prostate biopsy & focal therapy As a company, we welcome big challenges Compatible with all Ultrasound systems Compatible with all MRI scans! DICOM Compliant! Compatible with all Ultrasound systems Compatible with all MRI scans DICOM CompliantUsed in hospitals worldwide to improve diagnosis and management of prostate cancersU.S. Headquarter: Phone: 530.274.1240 x 221 Europe O ce:13366 Grass Valley Ave. Fax: 530.274.3656 Denshaw House,Grass Valley, CA 95945 [email protected] 120/121 Lower Baggot Street, Dublin 2 D02 FD4

Worldwide #1 Choice for Prostate Biopsy by Patients & DoctorsHighest number of biopsy cases Worldwide

Speci cations Artemis ProFuse Bx ProFuse General Storage • Class 2 equipment • 2–Serial ATA 1 TB hard disk • Mode of operation: Continuous • CD/DVD R/W Lightscribe drive • The unit has no patient applied parts CPU and System Memory • IP20 rating • Intel i7 3.33 GHz • 4 GB DDR3 DIMM Storage Video Card • 2–Serial ATA 1 TB hard disk • nVidia GeForce GTX760, • CD/DVD R/W Lightscribe® drive CPU and System Memory 1 GB RAM • Intel i7 3.33 GHz Framegrabber Card • 4 GB DDR3 DIMM • Matrox Morphis Video Card • nVidia GeForce GTX760, 1 GB RAM Framegrabber Card • Matrox Morphis Cart Dimensions • Width: 27\"x Length–Basic: 35\" • Cart Length w/ Arm Fully Extended: 64\" • Height: 57\" • Pole diameter: 4\" OD Power Supply Artemis has one of these four input power ratings, as indicated on the back of the device. Voltage Hertz @A max 100 50/60 8.33 A max 12050/60 8.33 A max 22050/60 4.17 A max 24050/60 4.17 A max

Eigen reserves the right to modify the speci cations andfeatures described herein. Please contact your authorized Eigen representative for the most current information or submit a request to “[email protected]” Currently Registered in Countries Around the World on Four Continents CE, FDA, TGA, CMDCAS As a company we welcome big challenges