Antibody Selection for ADC Drugs

Description: Antibodies are the precise guidance components of ADCs. In theory, molecules that bring effector molecules to the surface of tumor cells can play the role of antibody guidance.
The choice of antibody for ADC drugs depends on the target of the disease. Targets can be divided into tumor-specific antigens (TSA) and tumor-associated antigens (TAA) according to their expression. Antigens that are only expressed in tumor cells but not in normal cells are tumor-specific antigens and the most ideal targets; antigens that are lowly expressed in normal tissues but highly expressed in tumor tissues are tumor-related antigens and can also be used as suitable candidate targets. Tumor-specific antigens only exist on the cell membrane proteins or membrane protein complexes on the surface of tumor cells, mainly including pMHC mutations on the surface of tumor cells and membrane proteins with mutations in the extracellular region; tumor-related antigens can be subdivided into cell proliferation-related