What Optic Nerve Hypoplasia Means

What Optic Nerve Hypoplasia Means? Optic nerve hypoplasia (ONH) is an extremely rare congenital abnormality in which the optic discs are abnormally tiny and undeveloped. ONH is non-progressive and has a broad range of severity, from near normal central visual acuity to complete loss of light sensitivity in the worst instances. Although ONH may be present on its own, it is most often seen in conjunction with other eye abnormalities, facial deformities, and brain abnormalities. When ONH was first shown to be linked to optic nerve and midbrain degeneration, the diagnosis of septo-optic dysplasia (also known as \"de Morsier's Syndrome\") became a standard. This condition affects both the optic nerve and the midbrain. Neuronal axonal miswiring and decreased number of axons are the root causes of both ONH and septo-optic dysplasia. A functional or structural neurological problem, such as pituitary and hypothalamus mal-development, seldom results in ONH. ONH is now more common than previously thought, maybe as a result of increased knowledge of the link between ONH and brain abnormalities. Fewer than 30 occurrences were documented in English literature prior to 1970. The ONH was first discovered in the early 1980s by researchers in Houston, Texas. Between 1980 and 1999, the incidence of ONH quadrupled to 7.2 per 100,000 in Sweden, making it the major cause of newborn blindness in the country. ONH prevalence in England has increased to 10.9 per 100,000 people since 2006, according to the latest data. Even if the rise in ONH diagnoses may be ascribed to better detection and sensitivity, this is questionable since ONH is typically clearly observable with direct ophthalmoscopy and the increasing incidence is recorded from the same institutions. This new evidence disproves the previously held belief that ONH is in short supply. RISK FACTORS WHICH APPLY TO PREGNANCY

General ONH affects people of all races, however Asians seem to be less likely than other groups to be impacted. There is no evidence of a preference for one gender or the other. Genetic Specific genetic mutations have been shown to influence optic nerve development; however, only one gene (HESX1) has been shown to influence both optic nerve and pituitary development simultaneously. HESX1 is discovered in fewer than 1% of ONH patients, making it an improbable cause of the disease. There are no known genetic or phenotypic relationships. On the other hand, Optic Nerve Hypoplasia stem cell treatment may be detected just on one side of the body. Approximately 15% to 25% of severe vision loss in neonates is caused by ONH, and when bilateral, 80% of patients are legally blind. Call us: 9650760803 Email id: [email protected] Follow us https://www.facebook.com/Viezec https://twitter.com/Viezec123 https://in.pinterest.com/Viezec/ https://www.instagram.com/viezec/