CSCTSPL Brochure Material

What is Stem Cell? Stem cells are precursor, unspecified, undifferentiated group of cells capable of self proliferation, migration and differentiation. Stem Cells are the cells that are able to give rise to more specialized cells, or differentiate into a specific cell type and appear to be one of the body's ablest tools for self- repair. When a disease or injury strikes, these stem cells respond to specific signals and set about to facilitate healing by differentiating into specialized cells required for the body's repair. That is, provided they exist in sufficient numbers and receive the correct signals when disease or injury occurs. When they do not, the end result is an inadequate or compromised healing response. Characteristics of Stem Cell: There are two important characteristics of stem cells from other cells in the body:- 1. Stem cells can replenish their nature for long period through cell division. 2. Stem cells can differentiate or transform into specialized cells with specific functions after recognizing some chemical signal in the body. Classification of Stem Cell: Stem cells can be classified into four broad categories, based on their ability on differentiation:- 1. Totipotent stem cells: Are found only in early embryos, each cell can form a complete organism. 2. Pluripotent stem cells: Exist in the undifferentiated inner cell mass of the blastocyst and can form all of the over 200 different cell types in the body. 3. Multipotent stem cells: Are derived from fetal tissue, cord blood, bone marrow etc. although their ability to differentiate is more limited than pluripotent stem cells. 4. Unipotent stem cells: Are found in multipotent cells and adult tissues. They are also able to renew and give rise to only a single mature cell type.

Stem Cell Treatment: We have our team of experts (Researcher & Clinician) and they are always ready to provide each and every solution regarding stem cell therapy (It may be Patient/Clinician related). We are providing stem cells in different form as per the requirement of best suite on the basis of degenerative disease application. AUTOLOGOUS STEM CELLS (HARVESTED FROM SAME PATIENT) TREATMENT: 1. Bone Marrow Derived Stem Cells Concentrate: Bone Marrow derived autologous (same patient) stem cell is the natural stem cell and has the capacity to differentiate into multi lineages after transplantation at the injury site. Bone marrow cell population contains significant concentrations of hematopoietic, mesenchymal and endothelial progenitor stem cells. 2. Cultured Bone Marrow Stem Cells: Cultured bone marrow is a highly effective stem cell therapy. We provide cultured cells after the evaluation of the some specific patient case study. It is the process to make Mesenchymal stem cells (MSCs) in the quantity of millions via culturing the stem cells for 2-3 weeks because MSCs is the multipotent stem cells which can differentiate into bone cells, cardiac cells, cartilage cell, skin cells and others. MSCs appear to possess unique properties that may allow for convenient and highly effective cell therapy. 3. Autologous Cartilage Implanatation(ACI): ACI is the best treatment option for cartilage defects (if defect size is in mm or cm). It provides very fast recovery of damaged cartilage surface area in a proper way. It is more effective treatment because we provide autologous cartilage cell in the quantity of millions (near about 18-20 millions) via culturing cells for 3-4 weeks. 4. Cultured Limbal Stem cells: Limbal epithelial stem cell transplantation is the only treatment option for corneal damage or limbal stem cell deficiency (LSCD) due to chemical and thermal injury to improve the eye re-epitheliazation, visual acuity. Corneal limbus is the border of the cornea and it contains epithelial stem cells which is useful to regenerate the corneal revascularization. ALLOGENIC STEM CELLS (DONATED STEM CELLS) TREATMENT: 1. Cord Blood derived Hematopoietic Stem Cells: Cord blood derived stem cells are most commonly used in the treatment of blood related disorder like Leukemia or blood cancer. They are most effective when the leukemia is in remission and cord blood derived stem cells is the rich source of hematopoietic stem cells (CD34+).

2. Cord Tissue derived Mesenchymal stem cells (MSCs): Cord tissue derived MSCs transplantation is also one of the effective treatment same as bone marrow derived MSCs because Cord tissue derived MSCs have very good regeneration capacity. So we can use cord tissue derived MSCs as an allogenic for needed patients because cord tissue derived MSCs has no surface antigen so there is no rejection problem. Conventional Treatment Vs. Stem Cell Therapy At present, you can find the conventional treatment option for a number of disorders, which are not very much effective, however, with an option like the stem cell therapy, you can find a load of promising results coming on its way in the entire the world. This is simply possible owing to the fact that this procedure is known to have a number of features found in the stem cells. The fact of the matter is this treatment option promises loads of unique features, which is speed, safe and often completed within a day or two. Yet, you can find the results to be far better than the long and uncompetitive for the conventional therapies. It is astonishing to see that stem cell therapy employing the stem cells from different sources, including the ones from the bone marrow & umbilical cord, has been successfully employed to treat a wide number of life-threatening ailments with a good outcome, since the year 1988. Over the past number of years, with the increased research and development activities, a growing amount of successful stem cell treatments that have emerged. It has become one of the keys and exciting areas of medicine, which is seen encompassing all the areas of the current medical science. The Stem Cell Therapy in India There have been a quick growth of stem cell therapies in India and is not being very much overambitious in order to believe, which in India and the world that could one day in order to replace the costly and painstakingly protracted and very much routinely infective traditional therapies for things like treating a number of multitude of a chronic disorder and acute problems. In other words, the stem cells can be called the “force of nature” which is responsible for healing the wounds, organ growth and repair of various issues in the patient. This is not all, as you can find adding up the rejuvenating effects that can be known as the “real” fountain of youth. However, when it comes to reaping the best benefits of stem cell therapy, there is no dearth for the same, which can be enjoyed here in this country. Treatable Diseases: A Bone Marrow or Cord Blood transplant may be the best treatment option or the only potential for a cure for patients with Leukemia, Lymphoma, Sickle Cell Anemia and many other diseases. As the science of transplant continues to advance, new diseases are being treated with transplant.

Leukemias and Lymphomas, Including: Acute Myelogenous Leukemia (AML) The most common type of Acute Leukemia with nearly 15000 new cases found each year. AML can affect people of any age, but is most common in adults. Acute Lymphoblastic Leukemia (ALL) There are about 6000 new cases of ALL found each year. It can affect people of any age. Chronic Lymphocytic Leukemia (CLL) Primarily an adult disease, CLL is very rare in children and young adults. About 15000 people are diagnosed each year. Chronic Myelogenous Leukemia (CML) A relatively common form of Leukemia, it affects more than 20000 people with 6000 new cases each year. Most cases of CML appear in adults. Juvenile Myelomonocytic Leukemia (JMML) JMML, a rare cancer of the blood that affects young children, happens when types of white blood cells called monocytes and myelocytes do not mature normally. JMML can happen spontaneously (by chance) or can be associated with other genetic disorders in some children. Hodgkin Lymphoma (HL) HL is a type of lymphoma in which cancer originates from a specific type of white blood cells called lymphocytes. Symptoms may include fever, night sweats, and weight loss. Often there will be non- painful enlarged lymph nodes in the neck, under the arm, or in the groin. Non-Hodgkin Lymphoma (NHL) Each year about 69000 people are diagnosed with NHL. Most of these people are older than 60. Bone Marrow Diseases and other Diseases when Bone Marrow fails to work, including: Severe Aplastic Anemia (SAA) A rare disease with 600-900 people diagnosed each year. The disease appears more often in Asian Countries. It can affect people of any age, but is most common in young adults. Fanconi Anemia Fanconi anemia is a rare disease passed down through families (inherited) that mainly affects the bone marrow. It results in decreased production of all types of blood cells. This is the most common inherited form of aplastic anemia. Fanconi anemia is different from Fanconi syndrome, a rare kidney disorder.

Paroxysmal Nocturnal Hemoglobinuria (PNH) PNH is a rare acquired, life-threatening disease of the blood. The disease is characterized by destruction of red blood cells (hemolytic anemia), blood clots (thrombosis), and impaired bone marrow function (not making enough of the three blood components). Pure Red Cell Aplasia (PRCA) PRCA refers to a type of anemia affecting the precursors to red blood cells but not to white blood cells. In PRCA, the bone marrow ceases to produce red blood cells. Congenital Amegakaryocytic Thrombocytopenia (CAMT) CAMT is a rare, inherited disorder characterized by a severely low number of megakaryocytes, a type of bone marrow cell that makes platelets that are important for clotting and preventing bleeding. Inherited Immune System Disorders, including: Severe Combined Immunodeficiency (SCID) SCID is a group of inherited immune system disorders that are present at birth. They can become life-threatening within the first year of life if left untreated. Wiskollt-Aldrich Syndrome (WAS) WAS is an inherited immune system disorder that is present at birth. It affects mostly boys. Hemoglobinopathies (Diseases with poorly functioning Red Blood Cells), including: Beta Thalassemia Major Beta Thalassemia is an inherited blood disorder in which a child has anemia. It is caused by genetic defects that control the production of hemoglobin. The types are beta Thalassemia major, Intermedia, and minor. Treatment includes regular blood transfusions. Sickle Cell Disease (SCD) SCD is a group of blood disorders typically inherited from a person's parents. The most common type is known as Sickle Cell Anaemia (SCA). It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. It affects about 70000-100000 people each year. Inherited Metabolic Disorders, Including: Hurler Syndrome (MPS-IH) Hurler Syndrome is the most severe form of Mucopolysaccharidosis type 1 (MPS1), a rare lysosomal storage disease, characterized by skeletal abnormalities, cognitive impairment, heart disease, respiratory problems, enlarged liver and spleen, characteristic facies and reduced life expectancy. If not treated, children born with this disease usually die by 5 to 10 years of age.

Adrenoleukodystrophy (ALD) ALD, is a deadly genetic disease that affects 1 in 18 000 people. It most severely affects boys and men. This brain disorder destroys myelin, the protective sheath that surrounds the brain's neurons -- the nerve cells that allow us to think and to control our muscles. Metachromatic Leukodystrophy (MLD) MLD is a rare hereditary disease characterized by accumulation of fats called sulfatides. This causes the destruction of the protective fatty layer (myelin sheath) surrounding the nerves in both the central nervous system and the peripheral nervous system. MLD appears most often in babies and young toddlers, but it also occurs in older children and adults. MLD is rare. It occurs in about 1 in 40000 to 160000 individuals worldwide. Myelodysplastic Syndrome and Myeloproliferative Disorders Myelodysplastic/Myeloproliferative neoplasms are a group of diseases in which the bone marrow makes too many white blood cells. Myelodysplastic/myeloproliferative neoplasms are diseases of the blood and bone marrow. About 19000 people are diagnosed with MDS each year. Multiple Myeloma and other Plasma Cell Disorders Familial Erythrophagocytic Lymphohistiocytosis and other Histiocytic Disorders Certain other Malignancies or Cancers Umbilical Cord Stem Cells and upcoming uses:  Alzheimer’s Disease  Autism  Cartilage Repair  Cerebral Palsy  Congenital Hydrocephalus  Congenital Heart Disease  Diabetes Type 1  Liver Cirrhosis  Myocardial Infarction  Parkinson’s Disease  Spinal Cord Injury  Stroke  Traumatic Brain Injury  Amyotrophic Lateral Sclerosis

About Cell Match: CELL MATCH (A unit of Cryo Stem Cells Therapeutics Services Pvt. Ltd.), India’s one of the biggest Stem Cell registry was established in the year 2009 to provide Stem Cells Services in the field of Regenerative Medicine with a mission to save lives of those suffering from life threatening Blood Disorders like Blood Cancers, Thalassemia and Aplastic Anemia, Sickle Cell Anemia, Leukemia and other organ related disorder such as Muscular Dystrophy, Spinal Cord Injury, Diabetes, Chronic Kidney Disease (CKD), Cerebral Palsy, Autism, Optic Nerve Atrophy, Retinitis Pigmentosa, Lung (COPD) Disease and Liver Cirrhosis, etc. To enable Stem Cell Therapy with required quantity of Stem Cells, CELL MATCH provides Cryopreserved Cord Blood Stem Cells. We provide our services through some medical devices such as Bone Marrow Aspiration Concentrate (BMAC) kit, Platelet Rich Plasma (PRP) kit, stem cell banking and stem cells services (isolated from bone marrow, placenta and adipose) for research/clinical trial purpose only. CELL MATCH is also working towards creating a wide and diverse database of potential Blood Stem Cells donors that can be used for immediate therapeutic use. CELL MATCH is providing best stem cell therapy for the needed patients in all those application which can be treated by stem cell therapy. We have stem cells in different forms to make the better recovery of patient and refer the best stem cell solutions after the evaluation of patient case study by our experts. Our experts in this field work together with patients through the collaborative patient experience to give you greater peace of mind to develop clear evidence based path. We have highly experts in our team and our experts are strong in research and clinical research from both points of view. Our aim is to provide best stem cell therapy at reasonable price not only in India but also throughout the whole world so that every needed patients can get best stem cell therapy to improve his life. CELL MATCH SERVICES 1. Umbilical Cord Blood Stem Cell Banking: (2nd page of brochure will be taken hear) Baby’s Development in Womb Placenta: The placenta is an organ that develops in your uterus during pregnancy. This structure provides oxygen and nutrients to your growing baby and removes waste products from your baby's blood. The placenta attaches to the wall of your uterus, and your baby's umbilical cord arises from it. Umbilical Cord: The umbilical cord connects a baby in the womb to its mother. It runs from an opening in your baby’s stomach to the placenta in the womb. The average cord is about 50cm (20 inches) long.

Why Umbilical Cord Blood is best Source?  Easy to collect & can be preserved for indefinite period  Non Invasive procedure  Easier to find HLA matched Unit  Minimum Graft vs. Host Disease (GVHD) Process of Cord Blood Collection, Isolation & Storage of Stem Cells 1st Step : Enrollment (Agreement between Client and Company) 2nd Step: Client’s Health History (Health History of Mother, Father and Sibling will be asked at the time of enrolment) 3rd Step: Keep KIT safe (Cord Blood collection KIT provided at the time of Agreement need to be kept safe and carried to delivering hospital at the time of delivery) 4th Step: Cord Blood Collection (Cord Blood and Cord Tissues will be collected after delivery from Umbilical Cord) 5th Step: Transport KIT to LAB (Collected Cord Blood and Cord tissues will be transported to LAB for further process of isolation) 6th Step: Isolation of Stem Cells and Cryopreservation (Stem Cells will be isolated from Cord Blood and Cord Tissues and will be cryopreserved at -196˚C temperature in liquid phase for Agreement Period) 7th Step: Certificate of Cryopreservation (After the procedure of isolation and cryopreservation of Stem Cells, Client will be issued Certificate of Cryopreservation containing details of Quantity of preserved Stem Cells, Viability with respective markers) Who can use Baby’s Umbilical Cord Blood Stem Cells?  Baby  Sibling  Parent  Grand Parents  Close Relative Cord Blood Transplant Success Story The first Successful cord blood transplant was done on Matthew Farrow In 1988, Matthew, a 6 years old, then was diagnosed of Falconi Anaemia. Today, 29 years later Matthew is alive and lucky recipient of the world`s first cord blood transplant. (Family pic of Matthew Farrow will be added)

Why Choose Us?  Fastest processing time of less than 6 hours. This is very important when it comes to the viability and potency of stem cells.  CELL MATCH prefer to store Stem Cells in Cryo-Vials instead of Cryo-Bags. This enable us to use the stored stem cells for multi treatments. (*Cell stored in cryo-bags can only be used once.)  Access to future – ready solutions to treat major life-long or consuming diseases of heart, brain, liver and pancreas.  CELL MATCH to transport your sample as per requirement to your desired place of transplant.  Only company in India to have the technology and expertise of preserving stem cells from 10 different sources like umbilical cord, bone marrow, etc.  The only company in India to offer stem cell banking & various therapy options under one roof.  Tie-up with all leading hospitals all over India as well abroad.  HLA test pre-determines the genetic HLA profile of your baby’s Stem Cells and identifies close matched recipients in the family who may require stem cells for transplantation.  CELL MATCH has always been a supporter of the most ethical and accepted practices in stem cell banking and therapy. CELL MATCH Client Benefit Programmes: Free HLA Typing: If the Child or Child’s biological sibling or Child’s biological parent including grandparents required Stem Cells to treat a condition diagnosed, Cell Match shall perform HLA typing on the Stem Cells and recipient’s peripheral blood and CFU assay on the Stem Cells Transplant Programme: If the Child or Child’s biological sibling or Child’s biological parent including grandparents is diagnosed conditions treatable by approved Stem Cell transplantation, the Client can avail up to Rs.25,00,000/- to offset actual transplantation cost. Additional Unit: If the Child or Child’s biological sibling or Child’s parent including grandparents is scheduled for an approved stem Cell transplant and if the transplant physician suggests the requirement of an additional Unit then the Child or sibling or parent including grandparents is entitled to an appropriately matched additional Unit from Public Stem Cell Repositories. Free Supplementary Unit: If the Child or Child’s biological sibling or Child’s biological parent including grandparents require Cord Blood Stem Cells to treat a condition diagnosed, and if the same do not match the HLA requirement, Cell Match will provide a suitably matched unit from public repositories at no additional cost.

Mesenchymal Stem Cells: Cell Match shall provide 50 million Mesenchymal Stem Cells derived from the Child’s Umbilical Cord Tissue, as and when need be, for the Child or Child’s biological sibling or Child’s biological parent; provided the treatment is indicated for any condition approved by Indian Regulatory Authorities. Quality Assurance: In case the stored Unit proves to be unsuitable for treatment, under the quality assurance from program Cell Match will provide an appropriate supplementary unit from public Cord Blood registry. In case such unit is not available, Cell Match will pay up to Rs.20,00,000/- to the Client against valid invoice for the purchase of Cord Blood Unit. Free Global Shipment: In the event of an approved stem cell transplantation for the Child or Child’s biological sibling or Child’s biological parent including grandparent, specimen would be made available for X-ray free transportation anywhere in the world without any additional cost towards transportation to client. Disaster Relief: If Stem cells are found to have been damaged or extinguished due to natural disaster or act of God, Cell Match shall use its best attempt to provide a suitably matched stem cell unit from Public Bank Registry at no additional cost within Fourteen (14) business days. If this is not possible, then Cell Match shall pay a sum of Rs.20,00,000/- compensation. Cord Tissue Treatment Assistance: If the Child or Child’s biological sibling or Child’s biological parent are scheduled for treatment using Umbilical Cord Stem Cells, Cell Match shall provide an amount of Rs.20,00,000 to the client. 2. Stem Cell Registry: Every three minutes, one person is diagnosed with a blood cancer. Every 10 minutes, someone dies from a blood cancer. That’s more than six people each hour or 148 people each day. Patients are searching for a cure. It could be you. The CELL MATCH Stem Cells Registry is operated by the National Marrow Donor Program (NMDP), dedicated to creating an opportunity for all patients to receive the marrow or umbilical cord blood transplant they need, when they need it. It is the largest and most diverse donor registry. Our partnerships with international and cooperative registries provide doctors with access to more than 35 million potential donors and more than 783,000 cord blood units worldwide. For patients diagnosed with leukemia, lymphoma and other life-threatening diseases, a bone marrow or cord blood transplant may be their best or only hope for a cure. Yet 70% of patients who need a transplant to do not have a fully matched donor in their family. They depend on CELL MATCH and our supporters to find a match to save their life. We also provide one-on-one support to patients and their families throughout the transplant journey.

Growing the CELL MATCH Registry to find a match for all patients Our registry includes more than 22 million selfless volunteers who stand ready to be a life-saving bone marrow donor. We also have more than 6,00,000 cord blood units listed on the registry. Because there are patients who can’t find a match, we need more people to join the registry, and to be there when they are called as a match. Connecting patients with life-saving bone marrow donors From the moment doctors search our registry for a donor to the safe delivery of the life-saving cells to patients’ bedsides for transplant – we are there every step of the way. Our global network counts on our technology, expertise and unparalleled logistical support at every step to make the transplant possible. Seeing the lives that are saved through transplant drives our never-ending passion and dedication to find the match they need. Supporting patients, caregivers and families We are dedicated to saving and improving the lives of our patients which is why we provide one-on- one support to patients and their families. We offer the resources and guidance they need throughout the transplant process – from deciding if transplant is right for them to adjusting to life after transplant. No question is too big or too small for us. 3. Therapeutics Services: Choose CELL MATCH because it is more economical in terms of affordability of the treatment & the cost of accommodation and treatment in India is reasonably priced. For those people who come to India for stem cell therapy is reasonable. Stem Cell Therapy is done to make new tissues in the body. These tissues can be taken from the bloodstream or from the Umbilical cord and also from an adult stem cell. Stem cell therapy in India is providing exceptional results. This therapy is new in India but currently, India is now a Hub for the Stem Cell Therapy. Ours is not a group, which simply confines to banking alone but we are among the company in India, which render the stem cells therapy that benefits along with banking. With us, we have a cutting- edge technology complemented with some of the highly dexterous and experienced kind of reversed medical professionals from health care and technical fields that are known to have treated hundreds and thousands of patients using the therapy called stem cell therapy. Though you can find the regular doses of stem cells when the child turns into an adult, it ensures a healthy and effective kind of life thereafter for the kid opting for this procedure for a number of ailments like Diabetes, Osteoarthritis, and Osteoporosis to name a few. People Choose Stem Cell therapy In India for following reasons:  Low Cost of Treatment

 Fast Consultation  Advanced technology  Proper Diagnosis and counseling  Safe and Effective Treatment  Speedy Recovery  Highest Success Rate  Safe And Secure Transactions  Homely environment And Hospitality  Best Accommodation and Food Provided  Treatment of various diseases. CELL MATCH is now becoming the biggest provider in the field of healthcare. Actually, the fact is, there is no shortage of the hospitals with international Standards and high-tech medical Labs in India. A large number of clinics and hospitals and Stem Cell Centers are providing the patients from around the world with stem cell therapy at a much affordable cost. We at CELL MATCH are providing various finest and excellent treatment options available with the latest technologies for treatment and diagnosis lined up by the latest medical equipment that gives high-quality stem cell treatment. The hospitals and Stem cell Centers in India we are providing are all Top Notch Elite hospitals with international standards of infrastructure and hospitality having committed medical professionals and paramedical staff with the well experienced qualified stem cell Therapist and doctors specialized in performing the stem cell treatments. When it comes to the rate of success of the stem cell therapy, we achieved around 90%-95 %. However, the Rate of success of the stem cell therapy varies from patient to patient and disease to disease, so one can only confirm the treatment success rate after diagnosis of the patient's condition. We take pride in being transparent and loyal with our patients and therefore every Stem cell that is being produced and developed in our laboratory is checked for viability, efficacy, and safety, before being used for transplant in the therapy. Our patient gets a certificate of analysis and diagnosis reports as proof of our promise to them. We work hard to develop new, more efficient and safe therapies and technologies that will be beneficial to the patients and bring Regenerative Medicine at the center of medical management of patients irrespective of the disease/ailments that they might be suffering from. We aim to be a global leader in providing every patient a highly customized stem cell therapy for an overall management of their disease/condition keeping Regenerative Medicine and Stem Cell Therapy in the center of therapeutic medicine. We provide patients a complete solution starting from Diagnosis preparation of the disease to the transplant of the Stem Cell, the safe and efficient quantity of quality stem cells are extracted from the source most suitable for the Stem Cell Therapy needs a disease to the actual transplant and post-transplant preparations and follow up Treatments for the patient. We provide integrated Stem Cell Therapy alongwith the conventional medicinal Therapy and thereby providing the patient the best care possible comprising of Medical and Surgical management alongwith Stem Cell Therapy Medicine for an all-around management of the disease. Our world-class GMP Stem Cell Lab is at the top of research and technology and in innovating the best and latest technologies to our collaborated medical practitioners, doctors and Stem cell

Therapist and Stem Cell Centers ultimately improving the life of thousands of patients annually and in finding natural, safe and effective way to treat and manage not only fatal diseases and severe conditions but also in preventive medicines, cosmetic therapy and Anti Ageing Treatments. We work in association with some of the best medical practitioners in the world at top class medical centers across the world in providing the therapeutic solutions and efficacy to our patients. We are constantly involved in various clinical trials and innovational research programs across the world to consistently improve and further provide the safety and efficacy of our technological advancement. This on our journey towards the Success and in search for the \"elixir of life\" Stem Cell Therapy in India is associated with doctors, stem cell experts and research scientists to continuously improve and provide the best effectiveness of the Stem Cell Therapy to our patients for improving their quality and health of their life. 4. Medical Tourism: Medical tourism in India is the way to experience world's best medical facilities at reasonable cost. Introduction: As everyone aware that in developed countries like USA, UK, Australia, New Zealand etc, it is really tough to bear the cost of medical expenses. India is a becoming the leader in providing medical care/treatment with world class facilities with very reasonable cost and CSCTSPL-Medical Tourism is getting popular as a leading brand for the overseas patients. India is a place to some of the best hospitals and specialty clinics in the world, offering world-class expertise, state-of-the-art facilities, and the distinct warmth of Indian hospitality. From the moment that a patient or his guardian contacts us and inform us what their medical needs are, from that moment, CSCTSPL-Medical Tourism starts taking initiative. CSCTSPL- Medical Tourism acts as a mediator between the patient and the hospital/clinic and work with the patient to determine the best facilities and staff to handle their particular medical needs. Why we should be chosen: CSCTSPL-Medical Tourism in India is providing best medical care with very reasonable price for needed patients. Our experts in this field work together with patients though the collaborative patient experience to give you greater peace of mind to develop clear evidence based path. We have highly medical expertise Physicians, Surgeons and Researchers in our team to resolve each and every patient’s related enquiry. CSCTSPL-Medical Tourism is involving not only in medical tourism but also in clinical research using stem cell therapy for degenerative and incurable diseases since last 2-3 years in India. So our medical experts always provide best solutions after evaluating complete patient condition. As we know that many diseases is not medically treatable and such patients does not have any other options to cure such type of incurable disease so we have specialized regenerative medical

team (Physician, Surgeons and Researchers) who involve in clinical applications using stem cell therapy and has performed many stem cell treatment cases for some specific degenerative/incurable diseases (mentioned below). CSCTSPL-Medical Tourism is providing Indian Medical Tourism provides Medical/Surgical services and Stem Cell Therapy for the following applications in different hospitals of India. Feel our expertization and choose from a long list of services. Cryo Stem Cells Therapeutics Services Pvt. Ltd. deals in the following services:- General Medical/Surgical Treatment Stem Cell Treatment for Degenerative Diseases Bariatric surgery Neuro-Applications: Cardiology 1. Brain Stroke/Injury Cardiothoracic surgery 2. Spinal Cord Injury Colorectal surgery 3. Spinal Fusion Drug and alcohol services 4. Autism Ear, nose & throat (ENT) 5. Cerebral Palsy Endocrinology 6. Motor Neuron Disease(ALS, PBP) Gastroenterology 7. Multiple Sclerosis (MS) General surgery Gynaecology Ortho- Applications: Haematology 1. Knee Cartilage Defect or arthritis Internal medicine 2. Hip Avascular Necrosis/Osteonecrosis Mental Health 3. Rheumatoid Arthritis Neurology 4. Non-Union Fracture/Delayed Union Neurosurgery Obstetrics, Gynaecology and IVF Vascular Applications: Oncology / cancer 1. Coronary Arterial Disease Oral and Maxillo surgery 2. Peripheral Arterial Disease such as CLI Orthopaedic (Knee/Hip) surgery 3. Diabetic Foot ulcer/Gangrene Pediatric surgery Physicians Eye related Application: Plastic & reconstructive surgery 1. Optic Nerve Damage Rehabilitation 2. Retinitis Pigmentosa Renal 3. Macular Degeneration Respiratory medicine Urology Other Applications: Vascular surgery 1. Diabetes 2. Acute/Chronic kidney disease 3. Acute/Chronic Liver disease 4. Acute/Chronic Lung disease 5. Muscular Dystrophy as DMD & SMA 6. Myocardial Infarction (MI) 7. Hair Regeneration 8. Blood related cancer treatment 9. Anti-aging

The CELL MATCH Differentiator:  Global Stem Cell Registry. Registered with NMDP (National Marrow Donor Program).  A new advanced technology for processing cord blood known as PrepaCyte-CB was developed, which yields the maximum recovery of healthy stem cells and provides superior red blood cell depletion over all other methods.  Associated with world major Public banks. Available adequate stem cell inventory for HLA matching.  The company having 10 Years of Experience in treatment of 80+ Hematopoietic blood disorders like Thalassemia, CGD , HLH , Falconi Anemia, Immune Deficiency Disorder and Infantile ALL.  Facilitated 6284 successful transplants in multiple diseases like Thalassemia, CGD , HLH , Falconi Anemia, Immune Deficiency Disorder and Infantile ALL .  Clinical Trials: Spinal Cord Injuries, Cerebral Palsy, Autism, Ischemic Stroke. Contact Us: (Last page slogan “Save Your Cells, Save Yourself” and Picture will be added) Cryo Stem Cells Therapeutics Services Pvt.Ltd. Kaliamman Koil St., Phase 1, Abirami Nagar, Virugambakkam, Chennai, Tamil Nadu-600092 Phone : +91 9587989908 | 1800 890 6230 Email : [email protected] Website : www.cellmatch.co.in | www.cellmatch.org