2022 Annual Report

2022 Annual Report Department of Surgery 1

Department of Surgery by the numbers 11 193 152 clinical divisions faculty physician assistants 5 10 6 ACGME-accredited non-ACGME-accredited ACGME-accredited surgical residency programs surgical fellowships surgical fellowships 27,950 194,532 operations performed 34 office visits 154 179 interns and residents fellows active grants $40.7M 44 research spending active clinical 2

A Letter from the Chair Over the past year, the Department of Surgery has continued to build on our proud history of clinical and academic achievement. This year we saw our faculty continue to grow as we welcomed 11 new faculty members. Our department leadership grew as well. Nancy L. Cho, MD, was appointed section chief of Endocrine Surgery; Stella E. Lee, MD, was named inaugural section chief of Rhinology; Eric Sheu, MD, PhD, was named inaugural section chief of Foregut and Bariatric Surgery; and George Tolis, Jr., MD, was named the inaugural section chief of Coronary Surgery and General Cardiac Surgery. It was an honor for both the department and our institution to have three faculty members appointed by President Biden to top government positions. Monica Bertagnolli, MD, was appointed to serve as director of the National Cancer Institute; Atul Gawande, MD, MPH, was appointed as assistant administrator of the U.S. Agency for International Development Bureau for Global Health; and Thomas Tsai, MD, MPH, was selected to serve as senior policy advisor for The White House COVID-19 Response Team. We had a number of exciting new clinical programs start this year. With the opening of the Center for Transgender Health (CTH), the Brigham is establishing itself as a leader in the field of transgender health and uniting staff and faculty within Mass General Brigham to advance research, education and advocacy for transgender people. The Center is co-led by two internationally recognized pioneers in gender-affirming health care, including plastic surgeon Devin O’Brien-Coon, MD, MSE. Our department continues to be on the cutting edge of surgical research with new grant funding to study the role of palliative care in surgery to improve care for older seriously ill surgical patients; investigate how immune cells utilize energy in breast tumors to identify novel strategies and enhance their ability to attack cancer cells; develop a novel therapeutic approach to overcome the failure of direct androgen receptor-targeted therapies in the treatment of lethal castration-resistant prostate cancer; and to understand why immunotherapy works for some but not others, and to extend its use for a greater number of patients. Our annual report highlights just some of the many examples of our ongoing commitment to excellence in clinical care, research and surgical education. Thank you for taking the time to read our report. We look forward to connecting with you again soon. Gerard M. Doherty, MD Moseley Professor of Surgery, Harvard Medical School Surgeon-in-Chief, Brigham and Women’s Hospital & Dana-Farber Cancer Institute Crowley Family Distinguished Chair, Department of Surgery, Brigham and Women’s Hospital 3

Faculty Department of Surgery The Brigham attracts internationally renowned surgeons who create pioneering breakthroughs that make a difference for patients today, as well as for generations to come. We are committed to delivering world-class, collaborative patient care with a profound human touch, while advancing scientific research and training the surgical innovators of tomorrow. Breast Surgery General and Gastrointestinal Surgery Bariatric and Foregut Surgery Tari A. King, MD Chief, Division of Breast Surgery Ali Tavakkoli, MD Eric G. Sheu, MD, PhD Anne E. Dyson Professor of Surgery in the Chief, Division of General and Section Chief, Bariatric and Field of Women’s Cancers Gastrointestinal Surgery Foregut Surgery Associate Professor of Surgery Assistant Professor of Surgery Thanh U. Barbie, MD Assistant Professor of Surgery Colon and Rectal Surgery Neil D. Ghushe, MD Instructor in Surgery Laura S. Dominici, MD Ronald Bleday, MD Associate Professor of Surgery Section Chief, Colon and Rectal Surgery Malcolm K. Robinson, MD Associate Professor of Surgery Associate Professor of Surgery Olga Kantor, MD, MS Joel E. Goldberg, MD Assistant Professor of Surgery Assistant Professor of Surgery David Spector, MD Jennifer L. Irani, MD Instructor in Surgery Alison Laws, MD Assistant Professor of Surgery Instructor in Surgery Nelya Melnitchouk, MD, MSc Thomas C. Tsai, MD, MPH Assistant Professor of Surgery Assistant Professor of Surgery Christina A. Minami, MD, MFA, MS Melissa M. Murphy, MD, MPH Assistant Professor of Surgery Instructor in Surgery Ashley H. Vernon, MD James Yoo, MD Assistant Professor of Surgery Elizabeth Mittendorf, MD, PhD Associate Professor of Surgery Robert and Karen Hale Distinguished Paul B. Davidson, PhD Chair in Surgical Oncology Instructor in Psychiatry Professor of Surgery Mark Gorman, PhD Faina Nakhlis, MD Instructor in Psychology Assistant Professor of Surgery Suniti Nimbkar, MD Assistant Professor of Surgery Esther Rhei, MD Assistant Professor of Surgery

Otolaryngology– Head and Neck Surgery General and Abdominal Oral Medicine Ravindra Uppaluri, MD, PhD Wall Surgery Chief, Division of Otolaryngology— Nathaniel S. Treister, DMD, DMSc Head and Neck Surgery Stanley W. Ashley, MD Chief, Division of Oral Medicine BWH Distinguished Chair in Otolaryngology Frank Sawyer Professor of Surgery Associate Professor of Oral Medicine, Associate Professor of Otolaryngology Infection, and Immunity Head and Neck Surgery John J. Froio, MD Instructor in Surgery Kentaro Ikeda, DDS, MPH, FDS RCSEd Donald J. Annino, MD, DMD Instructor in Oral Medicine, Infection, Assistant Professor of Otolaryngology Pardon R. Kenney, MD, MMSc and Immunity Head and Neck Surgery Senior Lecturer on Surgery Herve Y. Sroussi, DMD, PhD Thomas L. Carroll, MD Erika L. Rangel, MD, MS Associate Professor of Oral Medicine, Assistant Professor of Otolaryngology Assistant Professor of Surgery Infection, and Immunity Head and Neck Surgery Brent T. Shoji, MD Piamkamon Vacharotayangul, DDS, PhD Carleton E. Corrales, MD Assistant Professor of Surgery Instructor in Oral Medicine, Infection, Assistant Professor of Otolaryngology and Immunity Head and Neck Surgery Douglas S. Smink, MD, MPH Professor of Surgery Sook-Bin Woo, DMD, MMSc Christopher Dwyer, MD, FRCSC Professor of Oral Medicine, Infection, Instructor in Otolaryngology Head Edward E. Whang, MD and Immunity and Neck Surgery Associate Professor of Surgery Laura A. Goguen, MD Surgical Educators Associate Professor of Otolaryngology Head and Neck Surgery David C. Brooks, MD Associate Professor of Surgery Anthony A. Prince, MD Instructor in Otolaryngology Head Andrew Resnick, MD and Neck Surgery Lecturer on Surgery Eleni Rettig, MD Scott A. Shikora, MD Assistant Professor of Otolaryngology Professor of Surgery Head and Neck Surgery Rosh Sethi, MD, MPH Assistant Professor of Otolaryngology Head and Neck Surgery Jennifer J. Shin, MD, SM Associate Professor of Otolaryngology Head and Neck Surgery 5

Rhinology Plastic and Reconstructive Surgical Oncology Surgery Chandrajit P. Raut, MD, MSc Stella E. Lee, MD Andrea Pusic, MD, MHS Chief, Division of Surgical Oncology Section Chief, Rhinology Chief, Division of Plastic and BWH Distinguished Chair in Surgical Reconstructive Surgery Oncology Regan Bergmark, MD Joseph E. Murray Professor of Surgery Assistant Professor of Otolaryngology Professor of Surgery Thomas E. Clancy, MD Head and Neck Surgery Distinguished Scholar in Surgical Oncology Shailesh Agarwal, MD Assistant Professor of Surgery Alice Z. Maxfield, MD Assistant Professor of Surgery Mark Fairweather, MD Assistant Professor of Otolaryngology Assistant Professor of Surgery Head and Neck Surgery Justin Broyles, MD George Molina, MD, MPH Assistant Professor of Surgery Assistant Professor of Surgery Rachel E. Roditi, MD Jiping Wang, MD, PhD Instructor in Otolaryngology Head and Neck Matthew J. Carty, MD Associate Professor of Surgery Surgery Associate Professor of Surgery Charles H. Yoon, MD, PhD Assistant Professor of Surgery Benjamin P. Christian, MD Instructor in Surgery Endocrine Surgery Yoon S. Chun, MD Nancy L. Cho, MD Associate Professor of Surgery Section Chief, Endocrine Surgery Assistant Professor of Surgery Jessica Erdmann-Sager, MD Gerard M. Doherty, MD Assistant Professor of Surgery Moseley Professor of Surgery Atul A. Gawande, MD, MPH Lydia A. Helliwell, MD Cynthia and John F. Fish Distinguished Instructor in Surgery Chair in Surgery Samuel O. Thier Professor of Surgery Devin O’Brien-Coon, MD, MSE Matthew A. Nehs, MD Associate Professor of Surgery Assistant Professor of Surgery Dennis P. Orgill, MD, PhD Professor of Surgery Kavitha Ranganathan, MD Assistant Professor of Surgery Christian E. Sampson, MD Assistant Professor of Surgery Indranil Sinha, MD Associate Professor of Surgery Simon G. Talbot, MD Associate Professor of Surgery Erin Taylor, MD Member of the Faculty of Surgery 6

Thoracic and Cardiac Surgery Steven J. Mentzer, MD Cardiac Surgery Professor of Surgery Raphael Bueno, MD Sary F. Aranki, MD Chief, Division of Thoracic and Namrata Patil, MD, MPH Associate Professor of Surgery Cardiac Surgery Assistant Professor of Surgery Fredric G. Levin Distinguished Chair Robert S.D. Higgins, MD, MSHA in Thoracic Surgery and Lung Cancer Matthew Pommerening, MD President, Brigham and Women’s Research Member of the Faculty of Surgery Hospital Professor of Surgery Executive Vice President, Mass Matthew M. Rochefort, MD General Brigham, Thoracic Surgery Instructor in Surgery Elizabeth G. and Gary J. Nabel Family Professor of Surgery Antonio Coppolino, III, MD, MSc Raghu R. Seethala, MD Instructor in Surgery Assistant Professor of Emergency Akinobu Itoh, MD, PhD Medicine Member of the Faculty of Surgery Christopher T. Ducko, MD Assistant Professor of Surgery Desiree A. Steimer, MD Mohamed Keshk, MD Instructor in Surgery Instructor in Surgery Paula Antonia Ugalde Figueroa, MD Member of the Faculty of Surgery Scott J. Swanson, MD Hari R. Mallidi, MD Canepari Family Distinguished Chair Associate Professor of Surgery Michael T. Jaklitsch, MD in Thoracic Surgery Jack Mitchell Distinguished Chair Professor of Surgery Ashraf A. Sabe, MD in Thoracic Surgery Assistant Professor of Surgery Professor of Surgery Hisashi Tsukada, MD, PhD Assistant Professor of Surgery George Tolis, Jr., MD Mohamed Keshk, MD Assistant Professor of Surgery Instructor in Surgery Jon O. Wee, MD Assistant Professor of Surgery Transplant Surgery Hassan Khalil, MD Assistant Professor of Surgery Brian Whang, MD Stefan G. Tullius, MD, PhD Instructor in Surgery Chief, Division of Transplant Surgery Hari R. Mallidi, MD Joseph E. Murray Distinguished Chair Associate Professor of Surgery Abby A. White, DO in Transplant Surgery Assistant Professor of Surgery Professor of Surgery M. Blair Marshall, MD, FACS Michael A. Bell Family Distinguished Chair Daniel C. Wiener, MD Sayeed K. Malek, MD in Healthcare Innovation Assistant Professor of Surgery Assistant Professor of Surgery Associate Professor of Surgery John Young, MD Ciaran McNamee, MD, MSc Instructor in Surgery Assistant Professor of Surgery 7

Trauma, Burn and Surgical Urology Urologic Oncology Critical Care Adam S. Kibel, MD Steven L. Chang, MD, MS Ali Salim, MD Chief, Division of Urology Section Chief, Urologic Oncology Chief, Division of Trauma, Burn DiNovi Family Distinguished Chair in Assistant Professor of Surgery and Surgical Critical Care Urology BWH Distinguished Chair in Surgery Elliott Carr Cutler Professor of Surgery Matthew Mossanen, MD, MPH Professor of Surgery Assistant Professor of Surgery William Boysen, MD Geoffrey Anderson, MD, MPH Member of the Faculty of Surgery Mark A. Preston, MD, MPH Assistant Professor of Surgery Assistant Professor of Surgery Timothy Clinton, MD, MPH Reza Askari, MD Member of the Faculty of Surgery Graeme S. Steele, MD Assistant Professor of Surgery Assistant Professor of Surgery Alexander P. Cole, MD Gustavo J. Bauzá, MD Assistant Professor of Surgery Quoc-Dien Trinh, MD Instructor in Surgery Associate Professor of Surgery Elodi J. Dielubanza, MD Christopher J. Burns, MD Instructor in Surgery Vascular and Endovascular Instructor in Surgery Surgery George Haleblian, MD Cristina Carpio, MD Assistant Professor of Surgery Michael Belkin, MD Instructor in Surgery Chief, Division of Vascular Martin Kathrins, MD and Endovascular Surgery Jason E. Cohen, DO Assistant Professor of Surgery John Anthony Mannick Professor of Surgery (HMS) Zara R. Cooper, MD, MSc Arthur F. Little, MD Michele and Howard J. Kessler Instructor in Surgery Garima Dosi, MD Distinguished Chair in Surgery and Public Health Michael W. McDonald, MD Edwin C. Gravereaux, MD Associate Professor of Surgery Assistant Professor of Surgery Instructor in Surgery Enobong J. Efiong, MD Kathy Golbarg Niknejad, MD Mohamad Hussain, MD, PhD, RPVI Member of the Faculty of Surgery Member of the Faculty of Surgery David W. Fink, MD Instructor in Surgery Michael P. O’Leary, MD, MPH Edward J. Marcaccio, Jr., MD Professor of Surgery Assistant Professor of Surgery Joaquim M. Havens, MD Associate Professor of Surgery Daniel A. Wollin, MD Matthew T. Menard, MD Assistant Professor of Surgery Associate Professor of Surgery Anupama Mehta, MD Instructor in Surgery Louis L. Nguyen, MD, MBA, MPH Associate Professor of Surgery Stephanie L. Nitzschke, MD, MS Assistant Professor of Surgery C. Keith Ozaki, MD John A. Mannick Professor of Surgery Nakul Raykar, MD, MPH (BWH) Member of the Faculty of Surgery Professor of Surgery Robert Riviello, MD, MPH Marcus E. Semel, MD, MPH Steven C. and Carmella R. Kletjian Instructor in Surgery Foundation Distinguished Chair in Global Surgery Associate Professor of Surgery Naomi Shimizu, MD Instructor in Surgery Kristin A. Sonderman, MD, MPH Assistant Professor of Surgery 8

Research Li Jia, PhD Education Lead Investigator Matthew Brian Couger, PhD Assistant Professor of Surgery Jamie Robertson, PhD, MPH Lead Investigator Director of Innovation in Surgical Education Member of the Faculty of Surgery Raouf A. Khalil, MD, PhD Assistant Professor of Surgery Lead Investigator Marie Billaud, PhD Associate Professor of Surgery Emeritus Lead Investigator Member of the Faculty of Surgery James A. Lederer, PhD Francis D. Moore Jr., MD Lead Investigator Francis D. Moore Professor of Surgery, Zi Chen, PhD Associate Professor of Surgery Emeritus Lead Investigator Assistant Professor of Surgery Farhad Rikhtegar Nezami, PhD Anthony D. Whittemore, MD Lead Investigator Professor of Surgery, Emeritus Assunta De Rienzo, PhD Assistant Professor of Surgery Lead Investigator Michael J. Zinner, MD Assistant Professor of Surgery Steven Piantadosi, MD, PhD Moseley Professor of Surgery, Emeritus Senior Investigator Tanujit Dey, PhD Professor in Residence of Surgery Affiliated Lead Investigator faculty Assistant Professor of Surgery William G. Richards, PhD Lead Investigator South Shore Hospital Maria Edelen, PhD Assistant Professor of Surgery Lead Investigator Frederick Millham, MD Associate Professor of Surgery Gilbert Welch, MD, MPH Chair of Surgery, South Shore Hospital Senior Investigator Ann Marie Egloff, PhD, MPH Veteran’s Affairs (VA) Boston Lead Investigator Joel S. Weissman, PhD Healthcare System Assistant Professor of Surgery Senior Investigator Professor of Surgery General Surgery Jennifer Guerriero, PhD Lead Investigator Jeremy M. Wolfe, PhD Kamal Itani, MD Assistant Professor of Surgery Senior Investigator Chief of Surgery, VA Boston Healthcare Professor of Ophthalmology System Molly Jarman, PhD, MPH Jason S. Gold, MD Lead Investigator Feng Yao, PhD Gentian Kristo, MD Assistant Professor of Surgery Lead Investigator Ann Smith, MD, MPH Associate Professor of Surgery Cardiac Surgery Miguel Haime, MD Jacquelyn A. Quin, MD Marco Zenati, MD Plastic Surgery Shahe Fereshetian, MD Urology B. Price Kerfoot, MD Juan Garisto, MD Vascular Surgery Joseph Raffetto, MD Research Vivian Cristofaro, PhD Aldebaran Hofer, MD, PhD Maryrose P. Sullivan, PhD 9

Welcoming Robert S.D. Higgins, MD, MSHA, as President of Brigham and Women’s Hospital and Executive Vice President of Mass General Brigham A distinguished academic and these regions, having also overseen faculty, staff, trainees and students. clinical physician with a long track the surgical services program at Johns He also has served as senior associate record of collaborative leadership, Dr. Hopkins All Children's Hospital, a dean for Diversity and Inclusion. Higgins served as the William Stewart pediatric acute care children's hospital Halsted Professor of Surgery at Johns located in St. Petersburg, Florida. Prior to joining Hopkins, Dr. Higgins Hopkins School of Medicine, director served as Department of Surgery chair of Hopkins’ Department of Surgery Dr. Higgins’ leadership was also and director of the Comprehensive and surgeon-in-chief. Dr. Higgins is the central to the launch of Hopkins’ first Transplant Center at The Ohio State first Black president at Brigham and systemwide multidisciplinary service University Medical Center from 2010 Women’s Hospital. line, the Comprehensive Transplant to 2015. He has served in numerous Center (CTC). With heart, lung, national professional leadership roles, Dr. Higgins is a proven innovator abdominal and vascular programs including president of the Society of with the ability to manage complex for adult and pediatric patients, Thoracic Surgeons (2019-2020), the multidisciplinary services at world the program has been recognized United Network for Organ Sharing class organizations, and a passionate nationally and internationally for (2009-2010) and the American College advocate for research with a life- exceptional quality outcomes. of Surgeons Society of Surgical Chairs long commitment to training the next (2019-2020), as well as member of the generation of exceptional people in As chair of the storied Department of Board of Directors of the American health care. In so many ways, he is the Surgery at Johns Hopkins, Dr. Higgins Board of Thoracic Surgery. ideal choice at this critical moment in is a pioneer with remarkable clinical our history to lead the Brigham, one of and academic accomplishments. He is Dr. Higgins earned his bachelor’s the world’s foremost academic medical widely regarded as a leading authority degree from Dartmouth College and centers, and join the senior leadership in heart and lung transplantation, medical degree from Yale School of team at Mass General Brigham to help adult and pediatric cardiac surgery Medicine. He completed a residency set the system’s strategic direction. and mechanical circulatory support. in general surgery and served as chief Dr. Higgins is renowned as a world resident at the University Hospitals A highly regarded and accomplished class surgeon scientist. Recognized of Pittsburgh. He was a Winchester leader, Dr. Higgins led the enterprise- nationally and internationally for his Scholar and fellow in cardiothoracic wide clinical expansion of the Hopkins research in the areas of heart and surgery at the Yale School of Medicine. surgical services program—the second lung transplantation and disparities He earned a master’s degree in largest academic department in in outcomes in cardiac surgery, Dr. health services administration at Hopkins’ School of Medicine—across Higgins has led the Hopkins research Virginia Commonwealth University. Dr. the Maryland, Washington D.C. and program and NIH funding through a Higgins served as a senior registrar Mid-Atlantic regions at five hospitals period of exponential growth. in transplantation at the renowned and multiple ambulatory locations. Dr. Papworth Hospital, the United Higgins’ impact extends well beyond Under Dr. Higgins’ leadership, the Kingdom’s largest cardiothoracic Hopkins surgical residency program surgical program and its main heart- earned the #1 surgical training program lung transplant center. He also served ranking by U.S. News for two years in a as a Major in the United States Army row. As a physician leader in academic Reserve Medical Corps for 13 years, medicine for over 25 years, Dr. Higgins and while doing so supported the successfully led the Hopkins School of Richmond Veterans Administration Medicine’s initiatives to recruit, retain transplantation program. and advance a highly accomplished 10

New Section Chiefs otolaryngology-head and neck surgery gut microbiota triggered by bariatric at Yale University, followed by a surgery lead to the resolution of type Nancy L. Cho, MD fellowship in rhinology and skull base 2 diabetes. His research has been Appointed Section Chief of Endocrine surgery at Johns Hopkins University. supported by numerous societies and Surgery philanthropic institutions, including the Before joining the Brigham, Dr. American Surgical Association, Harvard Dr. Cho received her BA from Harvard Lee served as the division chief for Catalyst, the Blavatnik Biomedical University and MD from Columbia Sinonasal Disorders and Allergy in the Accelerator, and the Consortia for University College of Physicians and Department of Otolaryngology at the Improving Medicine with Innovation and Surgeons. She completed residency University of Pittsburgh Medical Center Technology. training in general surgery and for ten years. fellowship training in endocrine surgery George Tolis, Jr., MD at the Brigham. She is an associate Dr. Lee is experienced in the Named Inaugural Chief of Section of surgeon in the division and an assistant comprehensive management of Coronary Surgery and General Cardiac professor of surgery at Harvard Medical patients with complex rhinologic, Surgery School. Dr. Cho also serves as associate allergic and skull base disorders. clerkship director for the Surgery Her research interests include Dr. Tolis received a Bachelor of Clerkship at the Brigham. characterization of the inflammatory Science in molecular biophysics and endotypes of chronic rhinosinusitis, the biochemistry from Yale College and a Her clinical interests include impact of environmental pollution on Master of Science in the same focus endocrine diseases of the thyroid/ airway inflammation and advancing the from Yale University. He received his parathyroid glands and melanoma. care of patients with cystic fibrosis and medical degree from Harvard Medical Her current research focuses on hereditary hemorrhagic telangiectasia. School. He completed general surgery investigating gender disparities in She is a leader in the development of training at Massachusetts General academic surgery, including award novel therapeutics and creation of new Hospital, a fellowship in cardiothoracic recognition, operative experience, paradigms of how we conceptualize and surgery at the Yale/New Haven Hospital conference speakers and society treat sinus and skull base disorders. and a fellowship in aortic surgery at the leadership. Dr. Cho has also published Mount Sinai School of Medicine. He is extensively on clinical outcomes in Eric Sheu, MD, PhD board certified in general and thoracic endocrine surgery to optimize delivery Named Inaugural Chief of Section of surgery. of patient care and improve surgical Foregut and Bariatric Surgery practices. She currently serves Before joining the Brigham, Dr. Tolis on committees for the American Dr. Sheu is a bariatric and minimally was a visiting surgeon and the quality Association of Endocrine Surgeons, the invasive surgeon at Brigham and director for the Division of Cardiac Society of Asian Academic Surgeons Women’s Hospital, an assistant Surgery at Massachusetts General and the Association for Academic professor of surgery at Harvard Medical Hospital. He has worked as a surgeon Surgery. School and the associate program in other medical institutions, including director of the advanced minimally Lenox Hill Hospital and St. Elizabeth’s Stella E. Lee, MD invasive surgery fellowship at the Medical Center, where he served as the Named Inaugural Chief of Section of Brigham. Dr. Sheu graduated from chief of the Division of Cardiothoracic Rhinology Harvard College, obtained his doctorate Surgery. in immunology as a Marshall Scholar Dr. Lee received a Bachelor of at Oxford University and completed Dr. Tolis’ clinical interests include Science in neuroscience and English medical school at Harvard Medical liberal use of multiple arterial grafting from Duke University and her medical School. He trained in general surgery at in coronary bypass surgery, use of degree from Chicago Medical School. the Brigham, followed by a fellowship extensive coronary endarterectomy to She completed her residency in in advanced laparoscopy and bariatric provide operative solutions for patients surgery at Massachusetts General who have been previously deemed Hospital. inoperable, surgery for native and prosthetic valve bacterial endocarditis Dr. Sheu’s clinical practice focuses on and open surgery to address failure of bariatric, foregut and hernia surgery. He percutaneous devices. His research directs an NIH R01-funded laboratory interests include investigation of factors that investigates how changes in 11

affecting quality reporting of various and his medical degree from Johns at one of the most vulnerable times cardiac surgical programs, which are Hopkins University School of Medicine. in their lives is imperative, especially not captured through standard risk He completed general surgery while ensuring their perspectives are adjustment models, and identification of training and a urology residency at acknowledged and appreciated. She optimal ways to enhance the operative Brigham and Women’s Hospital and a views her role as both systematic and surgical education of cardiothoracic fellowship in health services research collaborative, making sure patients are surgery trainees. at the Brigham Center for Surgery and compassionately cared for, educated Public Health. Following residency, and equipped to make safe informed New Faculty he completed a clinical fellowship in decisions, as she helps them navigate urologic oncology and image-guided the path to definitive treatment/surgical Timothy Clinton, MD, MPH therapeutics, which incorporated roles intervention. Urology as a urologic oncology fellow at the Brigham/Dana-Farber Cancer Institute Akinobu Itoh, MD, PhD Dr. Clinton received a Bachelor of Arts and a six-month rotation as a senior Thoracic and Cardiac Surgery in cell and molecular biology and music clinical fellow with the focal therapy from Tulane University and his medical team at the University College London Dr. Itoh received his undergraduate degree from the University of Texas Hospitals Trust. and medical degrees from the Tohoku Health Science Center San Antonio. He University School of Medicine in Sendai, also holds a Master of Public Health Dr. Cole’s research interests focus Japan. He completed resident training from the University of Texas School of on the interplay between health in general surgery and cardiovascular Public Health. Dr. Clinton completed a systems and health care delivery surgery at the NTT Medical Center in residency in urology at the University models, with a particular focus on Tokyo and a fellowship in cardiovascular of Texas Southwestern Medical Center. underserved minority populations. surgery at the National Cerebral and Following residency, he was a urologic His clinical focus is on the treatment Cardiovascular Center in Osaka, Japan. oncology fellow at Memorial Sloan of genitourinary malignancies, with a Subsequently, he completed a fellowship Kettering Cancer Center. focus on diagnostics and image-guided in cardiovascular surgery at St. Michael’s therapeutics. Hospital in Toronto, Canada and a Before joining the Brigham, Dr. Clinton fellowship in transplant/heart failure at was a clinical instructor of urologic Enobong J. Efiong, MD Toronto General Hospital. In 2013, he oncology in the Department of Surgery Trauma, Burn and Surgical Critical Care joined Washington University School of at Memorial Sloan Kettering Cancer Medicine/Barnes-Jewish Hospital as Center. Dr. Efiong completed a Bachelor a faculty member. Dr. Itoh also holds of Arts in psychology at New York a PhD in cardiac valve physiology and Dr. Clinton’s clinical interests are University and received her medical pathology from Tohoku University. in the treatment of all genitourinary degree from SUNY Upstate Medical malignancies, with a focus on University. She completed her general Before joining the Brigham, Dr. Itoh urothelial carcinoma and testicular surgery residency at Geisinger Medical was an associate professor of surgery, cancer, utilizing both open and robotic Center and a fellowship in surgical surgical director of the Heart Transplant approaches. His research interests are critical care from Georgetown University and Ventricular Assist Device Program defining the genomic determinants affiliated MedStar Washington Hospital and director of the Surgical Heart Failure of urothelial carcinoma and germ cell Center. Fellowship Program at the Washington tumors. University School of Medicine, as well as Dr. Efiong is double board certified co-director of the Barnes-Jewish ECMO Alexander P. Cole, MD in general surgery and surgical critical Program. Urology care. She is a member of various professional societies, including the Dr. Itoh’s main clinical focus is Dr. Cole received a Bachelor of Arts American Association for the Surgery of on orthotopic heart transplant and in philosophy from Harvard College Trauma (AAST), the American College mechanical assist device surgery. He of Surgeons (ACS) and the American also takes care of high-risk, complex Medical Association (AMA). aortic and mitral valve surgeries, as well as aortic dissection and aneurysm. Dr. Efiong’s areas of interest include Low ejection fraction coronary resident education and global health. artery revascularization surgery, with She believes regularly meeting patients 12

mechanical circulatory assist is another Dr. O’Brien-Coon directs a basic low-income countries through national area of his clinical interest. His clinical science lab focusing on cutaneous surgical planning, surgical education and translational research concerns repair, fibrosis and regeneration, as well and training. Additionally, she has are heart failure and the clinical impact as sex hormone-mediated control of interests in trauma education and of valvular surgery concomitant with wound healing and scarring. He is also resident development. mechanical assist device implantation interested in biomedical innovation and and reverse remodeling in mechanically has invented and successfully translated Desiree A. Steimer, MD unloaded condition. He’s also interested two FDA-approved medical devices Thoracic and Cardiac Surgery in the clinical outcomes of acute (a bioresorbable implant and a 3D circulatory support, with extracorporeal ultrasound system) to clinical use. Dr. Steimer is a graduate of Rhodes oxygen membrane circulatory support College and received her medical degree and other mechanical circulatory support His primary clinical areas are facial from the University of Kentucky. She devices, such as the intra-aortic balloon gender surgery, facial aesthetic surgery, completed surgical residency at Baylor pump and the Impella device. Based genital gender-affirming surgery and University and is board certified in upon his previous research experience genital/pelvic reconstruction for revision general surgery. Her thoracic training in valvular/ventricular physiology and or oncologic patients. includes a cardiothoracic surgical transesophageal echocardiography, residency and a fellowship in foregut he would like to contribute to the Kristin A. Sonderman, MD, MPH and general thoracic surgery; both development of the clinical and Trauma, Burn and Surgical Critical Care programs were completed at Brigham translational research in the heart failure and Women’s Hospital. field. Dr. Sonderman completed her undergraduate degree at the University She has an interest in minimally Devin O’Brien-Coon, MD, MSE of Wisconsin School of Medicine and invasive thoracic surgery and is a Plastic and Reconstructive Surgery Public Health, where she went on to recipient of the American Association receive her medical degree. She holds for Thoracic Surgery (AATS) Foundation Dr. O’Brien-Coon joins the Brigham an MPH from the Harvard T.H Chan Thoracic Surgical Robotics Fellowship. from Johns Hopkins University, where School of Public Health. She completed She is a member of various professional he was associate professor of plastic her general surgery residency at societies, including Women in Thoracic surgery and biomedical engineering. He Brigham and Women’s Hospital and a Surgery (WTS), the Society of Thoracic attended college and medical school at Paul Farmer Global Surgery Fellowship Surgeons (STS) and the American the University of Pittsburgh and holds a from the Program in Global Surgery College of Surgeons (ACS). master’s in biomedical engineering from and Social Change at Harvard Medical Johns Hopkins University. He completed School. She was also an Arthur Tracy Dr. Steimer’s clinical interest is integrated plastic surgery training at Cabot research fellow at the Center thoracic oncology, including lung cancer, the Johns Hopkins/UMD Shock Trauma for Surgery and Public Health at the esophageal cancer, thymic malignancies Center program and is board certified in Brigham. She most recently completed and mesothelioma. Her research will plastic and reconstructive surgery. a trauma and surgical critical care focus on improving patient education for fellowship at the R. Adams Cowley pre-surgical and postoperative care. Before joining the Brigham, Shock Trauma Center of the University Dr. O’Brien-Coon also served as the of Maryland. Erin Taylor, MD founding chief medical director of the Plastic and Reconstructive Surgery Johns Hopkins Center for Transgender Dr. Sonderman is a member of various Health, where he developed a professional societies, including the Dr. Taylor received her Bachelor of Arts multidisciplinary service line across American Medical Association (AMA), in mathematics from Bowdoin College eight departments that became one the Association of Women Surgeons and her medical degree from Columbia of the largest academic programs in (AWS) and the Society of Critical Care University College of Physicians and the U.S. He is recognized as a leader Medicine (SCCM). She is an associate Surgeons. She completed her plastic in genitourinary salvage procedures fellow of the American College of and reconstructive surgery residency at and is frequently referred secondary Surgeons and a fellow of the Eastern revision cases. He initiated and directed Association for the Surgery of Trauma the Johns Hopkins Complex Gender & (EAST). Microsurgery Fellowship. Dr. Sonderman’s research interests include surgical capacity building in 13

the Harvard Plastic Surgery Residency Paula Antonia Ugalde Figueroa, MD University of Pittsburgh Medical Center Program and received additional Thoracic and Cardiac Surgery Esophageal and Lung Surgery Institute. fellowship training in microsurgery at Memorial Sloan Kettering Cancer Center. Dr. Ugalde received her medical degree She is a board director and chair of the from the Federal University of Bahia Database Committee of the International Her research experience includes the Medical School in Salvador, Brazil, where Association for the Study of Lung National Institutes of Health, Columbia she also completed a master’s degree Cancer (IASLC), as well as member of University, Harvard Medical School and and a postdoctoral research fellowship the American Association of Thoracic Memorial Sloan Kettering Cancer Center. in lung volume reduction surgery. Surgery (AATS), the Society of Thoracic Her most recent research focuses on She completed her general surgery Surgery (STS) and Women in Thoracic postoperative pain control, patient- residency at the Santo Antônio Hospital Surgery (WTS), among other institutions. reported outcome measures after breast in Salvador, Brazil and a thoracic surgery Previously, Dr. Ugalde worked as the reconstruction, surgeon-based 3D residency at the Pavilhão Pereira Filho director of the Thoracic Oncology printing in vascularized bone transfer and Santa Casa da Misericórdia Hospital Research Program at the University free functional muscle transfer. She is an Department of Pulmonary Disease Institute of Cardiology and Pulmonology active participant in scientific societies in Porto Alegre, Brazil. Subsequently, of Quebec of the Université Laval, where and was previously on the Northeastern Dr. Ugalde completed a 2-year clinical she was also a clinical professor in the Society of Plastic Surgeons (NESPS) fellowship in thoracic surgery at Department of Surgery. Board of Directors. the Hôpital Laval Department of Pulmonology and Thoracic Surgery in Dr. Ugalde’s clinical and research Dr. Taylor’s clinical and research Quebec, Canada and a minimally invasive interests include innovation in minimally interests are complex oncologic thoracic surgery fellowship at the invasive lung surgery. She has the reconstruction, microsurgery and largest prospective database on lymphatic surgery. She is dedicated to uniportal surgery and has published resident and medical student education extensively on using this technique at Harvard Medical School and national for complex procedures. She is also conferences. dedicated to education and organizing several meetings and training programs, nationally and internationally. 14

Surgeons Harnessing the Power of the Immune System to Treat Early Cancers 15

When we think of cancer research “By bringing immunotherapy to monocytes, macrophages and natural and immunotherapy, surgeons don’t patients earlier in their disease, we’re killer cells impact how T cells work.” immediately come to mind. At the trying to advance clinical and functional The objective now is to figure out the Brigham, however, surgeons are taking outcomes, not just surgical outcomes,” additional checkpoint molecules and a leading role in immuno-oncology Dr. Uppaluri says. “There is a subset of other cells that play a role in immune research, led by Elizabeth Mittendorf, newly diagnosed patients who respond system responses to cancer cells. MD, PhD, director of the Breast Immuno- amazingly well to immunotherapy Oncology Program and co-director of and may therefore need less adjuvant Over the last two years, Dr. the Breast Cancer Research Program radiation or chemotherapy and maybe Uppaluri and his team have reported at Dana-Farber/Brigham Cancer Center even reduced extent of surgery.” promising results from Phase 2 trials (DF/BCC) and Ravindra Uppaluri, of neoadjuvant checkpoint inhibitor MD, PhD, chief of the Division of “As surgeons this is a big change. therapies in locally advanced squamous- Otolaryngology-Head and Neck Surgery Our goal has always been to get a good cell carcinomas of the head and in the Department of Surgery and chief outcome from surgery,” Dr. Uppaluri neck or oral cavity. Based on their of Head and Neck Surgical Oncology at says. “Now we are enrolling patients in findings, Phase 3 trials are under way DF/BCC. clinical trials to study tumors before and to confirm these findings, including after immunotherapy and gain insights the KEYNOTE-689 trial of adjuvant and “There is a real opportunity for into biological changes in the tumor neoadjuvant pembrolizumab combined surgeons to be involved in research and caused by the drugs.” with standard of care in patients with to expand research in immuno-oncology, resectable, locally advanced head and especially in the preoperative setting,” Dr. “This has been fairly common in neck squamous cell carcinoma. Positive Mittendorf says. breast cancer,” he explains, “but for results from the Phase 3 trials have the head and neck cancer, preoperative potential to change the way head and “As surgeons we have the opportunity immunotherapy represents thinking neck cancers are treated, explains Dr. to access biospecimens, such as tissue outside the box.” Uppaluri who serves on the steering and blood, from patients before, during committee for KEYNOTE-689. and after treatment,” Dr. Mittendorf Immunotherapy explains. “We are uniquely positioned to Targets Although checkpoint inhibitor therapy contribute to cancer research.” clearly works for some cancers, others “The vast majority of success in seem to be resistant to this form of Dozens of immunotherapies are cancer immunotherapy has been in immunotherapy. With funding from approved for use in the recurrent targeting the PD-1 and PD-L1 pathway,” the National Institutes of Health, Dr. and metastatic settings, and there is Dr. Mittendorf says. “Known as Uppaluri’s team has developed mouse incredible interest in taking this strategy checkpoint inhibitors, PD-1 and PD-L1 models in head and neck cancer that are to earlier disease stages. The natural put the brakes on T cells.” widely used to study immunotherapy timing, of course, is before surgery. response and resistance. With these Preclinical studies have shown that When the immune system is models, it is possible to examine stronger and broader immune responses stimulated, it sends out “go” signals neoadjuvant targets of tumor cells as can be generated if immunotherapy is telling immune cells to recognize they are seen by immune cells, thus administered while the tumor and/or and attack the invader and, shortly helping to understand how those targets draining lymph nodes are intact. thereafter, it sends out “stop” signals work. that are important for keeping the At this time, neoadjuvant or immune system in check. When fighting Beyond T Cells preoperative immunotherapy is cancer, though, you don’t want the approved for use in combination immune system to stop attacking The majority of approved cancer with chemotherapy in triple-negative cancer cells. PD‐1 is considered a immunotherapy drugs target T cells, the breast cancer and non-small cell lung checkpoint protein because it enables immune system cells that have memory cancer. The hope is that this approach the immune system to control the action and are able to recognize and remember of harnessing the immune system of T cells by either turning activation tumor cells to fight them when they grow. to fight cancer will also be beneficial signals up or down. The current in other types of cancer. Analysis of checkpoint inhibitors block checkpoint “What we know now after 20 years of biospecimens collected during surgery proteins such as PD‐1 on T cells or using these therapies clinically, is that are essential for understanding the PD‐L1 on tumor cells, allowing immune not all cancer types respond to T cell effects of immunotherapy at the tissue system eradication of cancers. therapies,” explains Jennifer Guerriero, and cellular levels. PhD, lead investigator in the Division of “This is just the tip of the iceberg,” Breast Surgery and assistant professor “Immunotherapy may be even more Dr. Mittendorf says. “It’s not all about of surgery at Harvard Medical School. effective in the preoperative setting the T cells. Other cells in the tumor “This has opened the door to thinking because patients haven’t had a lot of microenvironment, such as B cells, prior therapies that deplete the immune system,” Dr. Mittendorf explains. 16

about other immune cells in tumors that tumor and how to target it with therapies. Overcoming we might target.” “There is lots of optimism in trying Resistance to Immunotherapy “There is now growing interest in how to target macrophages because myeloid cells, such as macrophages, they are so abundant,” Dr. Guerriero “Understanding why some patients impact response to immunotherapy,” says. “Our group, in collaboration don’t respond has been the holy grail in Dr. Mittendorf says. Macrophages are with Dr. Mittendorf’s team, is using immunotherapy,” Dr. Uppaluri says. in every tissue and organ and are the biospecimens collected during surgery most abundant immune cells in tumors. to better understand the different cell A collaborative study with medical They are the first line of defense against populations.” Dr. Guerriero’s team is oncologist Catherine Wu, MD, at Dana- bacteria and pathogens, but they using immunoplex analysis to look at Farber Cancer Institute (DFCI) is using also help with tumor angiogenesis by 20 to 30 markers in each cell to identify single-cell RNA sequencing technologies travelling to tumors and providing factors their locations and spatial relationships to look at patient samples from clinical to help tumors grow. in both mouse models and surgical trials collected before and after patients biospecimens. receive therapy. The project may yield “Macrophages are very complex cells insights into which subsets of cells are and there is a lot we need to do to better Dr. Guerriero’s team is also using targeted by therapy, what changes over understand these cells,” Dr. Guerriero cyclic immunofluorescence, a technique time and what mechanisms may lead to explains. “We think macrophages may developed in the laboratory of Peter non-responsiveness to therapy. be one of the reasons T cell therapies Sorger at Harvard Medical School, which don’t not work in some cancers because allows the visualization of up to 60 Two recent finding from Dr. they interact with T cells and may be different markers of immune or tumor Guerriero’s team show the importance mitigating T cell activity.” cells on a single tissue section. In triple- of modulating macrophages to help negative breast cancer tumors, they saw immunotherapy succeed. They found Dr. Guerriero’s laboratory recently that tumor cells (white), macrophages that macrophages treated with a PARP completed RNA sequencing to look (green) and T cells (red) are in close inhibitor inhibited T-cell function and at the genetic makeup of each cell. In proximity in the tumor (see picture on activation, which limited tumor response doing so, they discovered 18 different page 15). It will be important to better to PARP inhibitor therapy. This work types of macrophages in hormone understand how this spatial relationship contributed to the design of a clinical trial receptor-positive breast cancer. Their influences tumor growth and response goal now is to determine what each type to therapy. of macrophage is doing in each patient’s 17

evaluating PARP inhibitors plus immune with head and neck cancers display burden; presence of CD8+, CD4 memory checkpoint inhibitors to further activate resistance to immunotherapy drugs, T cells, follicular helper T cells and M1 T cells as part of the Dana-Farber Breast with the goal of improving treatment macrophages; and inflammatory gene Program SPORE Award. In another response rates for this population. expression pathways. study, they identified a novel strategy to overcome PARP inhibitor resistance Sophisticated The team uses multidimensional through pharmacological targeting Immune Cell Analysis molecular profiling techniques to study of macrophages. This work revealed immune cell phenotypes and specific a previously unknown mechanism of Dr. Mittendorf’s team is collaborating cell functions in tissue, blood and stool PARP inhibitor resistance and laid the with researchers at DFCI, including specimens obtained before treatment, groundwork for future clinical trials to breast medical oncologist Sara Tolaney, after two cycles of treatment and before enhance PARP inhibitors plus immune MD, MPH, on sophisticated immune surgery. Their goal is to determine checkpoint blockade by targeting cell analyses to identify biomarkers which patients will benefit from immune macrophages. linked to immune checkpoint inhibitor checkpoint inhibitor therapy without therapy benefit. In a study of women experiencing toxicities (such as thyroid Dr. Uppaluri, along with DFCI’s David with metastatic triple-negative breast toxicity or damage to the adrenal glands) Barbie, MD, and Robert Haddad, MD, cancer treated with pembrolizumab and identify associations between are the principal investigators on a $4.3 and chemotherapy, they identified immune cell phenotypes and toxicities in million U01 Cancer Moonshot grant the following potential biomarkers the tumor microenvironment. The team from the National Cancer Institute (NCI) of response to immune checkpoint is currently working on these analyses and the National Institute of Dental inhibitor therapy: high tumor mutational for patients treated with neoadjuvant and Craniofacial Research (NIDCR) immunotherapy with a $1.9M grant from to understand why many patients the Breast Cancer Research Foundation. The Benefit for Patients Through multidisciplinary collaborations, the surgeons, medical oncologists, radiation oncologists and researchers at DF/BCC continue to explore ways to combine immunotherapy with chemotherapy, radiation and surgery to enhance patients’ response to treatment. At DF/BCC, patients can see all the providers involved in their cancer care in one day. “This seamless interaction among colleagues and patients works very well,” Dr. Uppaluri says. “It is incredible to be able to work so closely with clinical colleagues and surgeons to think about these problems and come up with solutions that will actually benefit patients,” Dr. Guerriero says. “Stimulating the immune system creates adaptive immunity that can continue for weeks, months, years and potentially for life,” Dr. Mittendorf says. “Immunotherapy may allow us to one day say that we have cured these patients.” 18

Center for Transgender Health Opens at the Brigham With the 2022 opening of the Center unique service that we are positioned to and patients. While it draws on the for Transgender Health (CTH), the provide here,” Dr. Doherty says. expertise of clinicians and surgeons Brigham is establishing itself as a leader from all over the Brigham, “Patients in the field of transgender health and Dr. Bhasin is a world-renowned benefit from a central administration uniting staff and faculty within Mass authority on testosterone biology space within the plastic surgery division, General Brigham to advance research, with 35 years of experience as a where the core staff ensures that education and advocacy for transgender leader in managing gender-affirming patients receive the care they need,” people. The center is co-led by two hormone therapy, including chairing Dr. O’Brien-Coon explains. internationally recognized pioneers in the Endocrine Society’s Expert Panel gender-affirming health care: Plastic for the development of Guidelines for By having dedicated staff to manage surgeon Devin O’Brien-Coon, MD, MSE, Testosterone Therapy. As a translational the complexities of insurance coverage, clinical director and surgical co-director; researcher, Dr. Bhasin’s research has led mental health assessments, scheduling and endocrinologist Shalender Bhasin, to new applications of androgens and physicians and making appointments MD, medical co-director. selective androgen receptor modulators. across multiple specialties, providers can focus on delivering care and patients The Leaders “This outstanding partnership and benefit from smoother care delivery. investment in transgender health care is Dr. O’Brien-Coon joined the Brigham a major milestone in this field of health “We have and are continuing to build from Johns Hopkins University, where care,” Dr. Bhasin says. a broad and skilled group for gender- he was the founding chief medical affirming surgery to get the best director of the Johns Hopkins Center for The Center outcomes for our patients,” Dr. O’Brien- Transgender Health, a multidisciplinary Coon says. “I think there is an unusually service line across eight departments The CTH consolidates and coordi- strong culture of collaboration and team- that has become one of the largest nates the provision of gender-affirming based care at the Brigham. For example, academic programs in the United States. care at the Brigham under one roof to there is one operating room suite where support transgender people at every step everyone works so we see each other “I was drawn to both the Brigham’s of their journey. The multidisciplinary daily and share updates on patients—not leadership interest in building a great team of plastic surgeons, endocrinol- every center has this luxury.” transgender health program and the ogists, dermatologists, urologists, collaborative pool of very talented gynecologists, otolaryngologists, voice As part of the centralized intake faculty here,” Dr. O’Brien-Coon explains. specialists, mental health care providers, process, regardless of the services, a He is referring to the vision of starting physical therapists, physician assistants, a program to become a national leader primary care providers, nurses and in transgender health shared by Gerard administrators work together to provide M. Doherty, MD, chair of the Department care for transgender patients. of Surgery, and Andrea Pusic, MD, chief of the Division of Plastic and At the CTH, patients can access the Reconstructive Surgery. complete range of gender-affirming surgeries, including facial, chest and “The Brigham has a long history of pelvic/urogenital procedures, as well as both compassionate longitudinal care gender-affirming hormone therapy. and complex surgical interventions. Successful transgender health care In creating the CTH, the Brigham requires both and is exactly the kind of has centralized the delivery of gender- affirming care and built an extensive infrastructure to support both providers 19

full-time social worker assesses each for nationally is engineering approaches a bioresorbable implant and a 3D patient to evaluate psychosocial and for reconstructive surgeries. For facial ultrasound system, through the entire social support needs and ensure they feminization surgery, he has developed process from initial concept to FDA receive all the services they require. A much of what is used in computer- approval and clinical use. dedicated part-time psychologist will based surgical planning, custom ensure that patients are prepared for implants and cutting guides. “Our research aims to understand the surgery and supported postoperatively effects of hormones on wound healing, throughout the care cycle. Community-Engaged so that we can find a way to reverse Research or control these effects for patient “Across the country, institutions are benefit,” Dr. O’Brien-Coon says. Such a building transgender health clinics. At the CTH, clinical, basic, and scientific advance would undoubtedly What is unique about our program is the translational researchers are have applications well beyond gender- sophisticated types of services and their collaborating on research to fill the many affirming surgery. seamless integration across providers existing knowledge gaps in gender- with high levels of expertise from many affirming care. Dr. Bhasin is involved in building large disciplines,” Dr. Bhasin explains. research consortiums to understand Dr. O’Brien-Coon directs a basic the epidemiology of health issues in Dr. Bhasin sees the center as a science research lab focusing transgender people. Along with Dr. tripartite entity composed of Care on cutaneous repair, fibrosis and Michael Goodman at Emory University, (surgical, medical, mental health), regeneration, including hormone- he leads a consortium to link major Pioneering Research, and Education and mediated control of wound healing. health care systems in the U.S. to Training of future health care workers He has experience with successful enable monitoring of health status in and researchers. translation of new innovations, having transgender people. previously invented and developed Internationally several medical devices, including “These data will be pivotal for Acclaimed Surgery allocation of resources and opportunities Program to advance transgender health,” explains Dr. Bhasin, who is also building a “We have essentially a destination Gender-Affirming Surgeries Available at CTH surgery program with a national and international patient base,” Dr. O’Brien- Top surgery Contouring a male chest via mastectomy Coon says. “These patients can choose (chest masculinization) or female chest to go anywhere, and they invest great (augmentation mammaplasty) effort in that decision. They talk to one another online and share experiences. Vaginoplasty Constructing a vagina and external female It’s vital that they have a good experience genitalia using penile or other tissue and feel comfortable with their doctors and nurses. Our long-term goal is to Phalloplasty Constructing a penis and scrotum using tissue make the Brigham known as the place from a donor site, as well as a new urethra and that everyone wants to travel to for their penile prosthetic surgery.” Metoidioplasty Constructing a penis using existing genital Dr. O’Brien-Coon and his team perform tissue the most complex reconstructive surgeries using 3D technology, tissue Facial gender Using various techniques, including bone engineering and biomedical engineering. surgery/facial contouring, augmentation and osteotomies, to When it comes to gender-affirming feminization reshape the bones and soft tissues of the face surgery, “We can do everything here, surgery and harmonize it with the patient’s gender no matter how complicated, including revision cases, which are ten times Orchiectomy Removal of the testes harder,” Dr. O’Brien-Coon says. “We have the right surgeons available and Hysterectomy / Removal of the uterus and/or ovaries eager to help, spanning a range of oophorectomy disciplines. Only a handful of places in the country offer the complete spectrum Vocal cord Changing the tone or pitch of the voice through of procedures.” surgery modification of the vocal cords One area Dr. O’Brien-Coon is known Revision/salvage Repair or correction of significant surgery complications after past gender-affirming surgeries 20

consortium of investigators to conduct “My work utilizes a participatory seeks to increase the number of gender- large interventional studies aimed at population perspective,” Dr. Reisner affirming care providers through an preventing suicide in the transgender explains. “There is a great need for online training course for continuing community. patient voices in health research and education credit and a provider community-engaged science,” he adds. network for remote synchronous and One such study, the TRANSessence asynchronous consultations with study, aims to better understand Dr. Reisner leads research on specialists at centers of excellence. epigenetic changes and other innovative ways to investigate and reduce biomarkers of stress, such as health inequities in the transgender “Our goal is to improve the capacity of inflammation, in transgender patients and gender diverse population. The health care providers to provide gender- and their association with stress LITE Study, a collaboration with Johns affirming care,” Dr. Reisner explains. This and traumatic experiences unique to Hopkins University that is funded by includes development of an app-based transgender individuals. Another, the the National Institutes of Health (NIH), intervention for transgender and gender Trans Health Equity Study, is assessing enrolled and follows more than 1,200 diverse youth and their families in met and unmet care needs, barriers and transgender women in the eastern collaboration with researchers at Boston facilitators to care in transgender and and southern U.S., evaluating health Children’s Hospital that would allow for gender diverse (TGD) patients. vulnerabilities and resiliencies. “We evaluation of outcomes over time and witness transgender women’s lives determining ways to intervene to reduce Sari Reisner, ScD, epidemiologist unfold over two to four years of cohort suicidality and improve mental health. and director of Research at the CTH, follow-up and assess health status—it’s heads a global portfolio of community an honor when communities participate “Gender affirmation—whether social, engaged transgender and gender in the research.” psychological, medical or legal—is a key diverse health research that employs determinant of health for transgender community‑centered practices for The ongoing NIH-funded and gender diverse people. I have an engaging transgender and gender TransHealthGUIDE intervention trial interest in how gender-affirming care diverse patients in population-based and aims to address suicide in TGD youth. Its can improve lives,” Dr. Reisner says. clinical research studies. provider training and support program To that end, he is a lead investigator (a) (b) A 43-year-old transgender woman who underwent facial feminization, including the frontal sinus, orbits, and jaw in stage one with rhinoplasty and rhytidectomy in stage two. (a) Preoperative and (b) postop photos six months after second stage. (c) 3D facial surface scans from pre-surgery to post-stage one to post-stage two. (c) 21

for The LEGACY Project funded by the development manager in the Department “As a social scientist, I use different Patient-Centered Outcomes Research of Surgery, the nursing staff were eager types of patient-centered research Institute (PCORI). The LEGACY cohort, to learn something new. Dr. O’Brien-Coon tools to assess factors such as gender a collaboration with Fenway Health in along with Michael Parisi, PA-C, and minority stress, well-being, suicide risk Boston and Callen-Lorde Community Melissa Noyes were ready to share their and depressive symptoms,” Dr. Reisner Health Center, follows more than 4,500 expertise with a nursing staff that was says. As an underrepresented population transgender and gender diverse primary just as enthusiastic to care for such a in health care, learning about the care patients to assess the impact of vulnerable population. health and social needs of transgender gender-affirming hormones on HIV and gender diverse patients through prevention and treatment and mental “We held educational meetings and questionnaires is crucial to providing health. sessions with the staff in preparation for care. “In addition to clinical care, research caring for postoperative phalloplasty and also needs to be gender-affirming for Pioneering Education vaginoplasty patients. Resource binders transgender and gender diverse people.” and Training were made, tip sheets created, and our clinical nurse educators were trained so Dr. Pusic, a renowned expert in patient- There is a critical shortage of they could provide at-the-elbow support, reported outcome metrics for surgery, is clinicians with expertise in gender- should our staff have questions,” Paley leading the international development of affirming care and a dearth of education says. “I am proud to support my staff GENDER-Q, the first universal, validated and training opportunities for those who as they continue to provide culturally measure for patient-reported outcomes seek it. There is also ample evidence competent care to all patients who come in gender care. “The goal of transgender of disparities in care for transgender through our doors.” surgery is to improve patients’ quality people. According to the U.S. of life and body image. The GENDER-Q Transgender Survey of almost 28,000 “It has been such a positive experience will be an important tool to understand transgender people, being transgender watching our teams come together the success of our outcomes and guide is one of the largest predictors of to provide the best care for patients. future innovation,” Dr. Pusic says. suboptimal health and mistreatment in Our nursing staff and nursing leaders medical settings in the U.S. partnered with multidisciplinary “The GENDER-Q tool will be a landmark colleagues to ensure a high level of for the way patient outcomes are As part of the Brigham’s commitment clinical care, while fostering a supportive measured in the field of transgender to eliminating these disparities, the environment for our patients as they health care,” Dr. O’Brien-Coon says. center aims to educate the next move through this life-changing generation of health care leaders and process,” says Karen Reilly, DNP, RN, Patient-reported outcomes will be a researchers to care for transgender MBA, NEA-BC, associate chief nursing major point of emphasis for the center, patients. These efforts include officer of Critical Care, Cardiovascular according to William Boysen, MD, the everything from integration of and Surgical Services. center’s primary urologic surgeon. “I’m transgender health care into medical excited about the research at the center student curricula to dedicated one- Patient-Centered Care focusing on improving the quality of month medical student rotations in the research in this area in terms of patient- center, to a yearlong fully integrated “The Brigham is a very patient-care reported outcomes and listening to the fellowship. The Division of Plastic and centered institution,” Dr. O’Brien Coon voices of patients to assess if we are Reconstructive Surgery now also has says. “And there is a lot of interest here in meeting our patient’s needs.” a clinical fellowship in complex gender transgender health.” and microsurgery for surgeons to learn Just Getting Started advanced gender surgery techniques. To that end, the CTH harnesses the expertise of its research director, Dr. As an organization, the Brigham is “At the center, we want to create Reisner, and the Brigham’s Patient- committed to diversity and equity in a community of people interested in Reported Outcomes, Value, & Experience health care, and the CTH reflects their transgender research and connect this (PROVE) Center, led by Andrea Pusic, commitment to underrepresented to the trainee program,” Dr. Reisner MD, chief of the Division of Plastic and communities. explains. Reconstructive Surgery. “Everyone here wants to have the It is also important to mention the Dr. Reisner’s approach to research best academic program in the country contributions and efforts made by the with the patient community, not on the for transgender health care,” Dr. nursing staff to prepare and ensure a community, ensures that transgender O’Brien-Coon says. Their mission is to positive experience to CTH patients. patients’ voices and concerns are woven deliver high-quality, specialized gender- into research protocols. And transgender affirming clinical care, develop the next According to Matthew Paley, MSN, faculty members, like Dr. Reisner, are generation of innovative practices and APRN, CNRN, AGCNS-BC, professional part of the community that helps to share them nationally. And they are just inform both research and care. getting started. 22

Three Department of Surgery Faculty Members Appointed by President Biden to Top Government Positions Monica Bertagnolli, MD, Appointed Atul Gawande, MD, MPH, Nominated Thomas Tsai, MD, MPH, Selected as Director of the NIH-Funded National as Assistant Administrator of the USAID as Senior Policy Advisor for the Cancer Institute Bureau for Global Health COVID-19 Response Team Dr. Bertagnolli specializes in Dr. Gawande’s role at U.S. Agency In his new role on the White House the surgical care of patients with for International Development (USAID) COVID-19 Response Team, Dr. Tsai gastrointestinal cancer and sarcoma, will focus on efforts to prevent child will help coordinate the national collaborating closely with colleagues in and maternal deaths, control the HIV/ testing and treatment response in a Medical Oncology, Radiation Oncology AIDS epidemic, and combat infectious collaborative effort across federal and Pathology to deliver comprehensive, diseases, such as COVID-19, tuberculosis agencies. One hallmark effort will patient-centered care. She is a clinical and malaria. The Global Health Bureau be continued expansion of the Test researcher who has long advocated supports field health programs and to Treat initiative, a national system for increasing diversity in cancer innovation with a portfolio of nearly of sites where people can receive research. Additionally, she has an $4.15 billion. COVID-19 testing and, if they are impressive history of basic science positive and treatments are appropriate, work in the laboratory, where she has During the coronavirus pandemic, immediately obtain a prescription for focused on understanding the role of Dr. Gawande cofounded CIC Health, an oral antiviral medication. Patients the inflammatory response in epithelial which operates COVID-19 testing and will receive all services at no charge tumor formation. vaccination nationally, and served as a through this program, which is focused member of the Biden transition COVID-19 on reaching high-risk, underserved She has led several initiatives within Advisory Board. He previously served populations. Dr. Tsai previously served NCI-funded Cancer Cooperative Groups, as a senior advisor in the Department as a senior advisor to the assistant where she facilitated the integration of of Health and Human Services in the secretary for Planning and Evaluation tumor-specific molecular markers into Clinton Administration. Dr. Gawande is in the U.S. Department of Health and nationwide cancer treatment protocols, founder and chair of Ariadne Labs, a joint Human Services during the Obama- improving the care and outcomes of center for health systems innovation, Biden Administration. Dr. Tsai’s most patients across the country. She has also and of Lifebox, a nonprofit organization recent research uses Medicare claims held numerous leadership roles in multi- making surgery safer globally. and other large national datasets to institutional cancer clinical research study the effectiveness and unintended groups, including group chair of the In addition, Dr. Gawande was a consequences of health policy Alliance for Clinical Trials in Oncology, longtime staff writer for The New Yorker interventions on the affordability, a nationwide NCI-funded clinical trials magazine and has written four New York accessibility and quality of health care in group. Additionally, she was the CEO Times best-selling books: Complications, the United States. of Alliance Foundation Trials, LLC, a Better, The Checklist Manifesto and Being not-for-profit corporation that conducts Mortal. He is the winner of two National Dr. Tsai is a graduate of Harvard international cancer clinical trials. Magazine Awards, AcademyHealth’s College, received his medical degree Impact Award for highest research from Stanford University School of Dr. Bertagnolli graduated from impact, a MacArthur Fellowship and the Medicine and completed an MPH Princeton University and attended Lewis Thomas Award. at the Harvard T.H. Chan School of medical school at the University of Utah. Public Health. He completed residency She trained in surgery at Brigham and Dr. Gawande graduated from Stanford training in general surgery at Brigham Women’s Hospital and was a research University and received his medical and Women’s Hospital, followed by fellow at the Dana-Farber Cancer degree from Harvard Medical School. a fellowship in minimally invasive Institute. She was formerly the Richard He holds an MPH from the Harvard bariatric and advanced GI surgery at E. Wilson Professor of Surgery in the T.H. Chan School of Public Health and Massachusetts General Hospital. Field of Surgical Oncology at Harvard completed residency training at Brigham Medical School. and Women’s Hospital. 23

Education Current Residents Logan Scoon, MD Georgetown University School of Medicine The Department of Surgery combines top-notch clinical care with world- General Surgery Alexander Boyko, MD class research and cutting-edge Boston University School of Medicine [IR] education to provide comprehensive Program Director: surgical training programs. Teaching Stephanie Nitzschke, MD, MS Austin Lai, MD tomorrow’s leaders today… Associate Program Directors: Saint Louis University School of Medicine [IR] Geoffrey Anderson, MD, MPH; Mark 154 Fairweather, MD; Jennifer Irani, MD; PGY 2 Matthew Nehs, MD; Naomi Shimizu, MD 34 PGY 1 Abena Appah-Sampong, MD fellows Categorical University of Chicago Pritzker School of Medicine Acgme-accredited surgical residency programs Christian Cullen, MD Orly Farber, MD Medical College of Georgia at Augusta Stanford University School of Medicine 6 University Jamie Hillas, MD Acgme-accredited John Gaspich, MD Geisel School of Medicine at Dartmouth surgical fellowships Pennsylvania State University College of Medicine Daniel Hoffman, MD 10 Perelman School of Medicine at the Olivia Lynch, MD, MPH University of Pennsylvania non-Acgme-accredited University of Rochester School of Medicine surgical fellowships and Dentistry Kara Kennedy, MD University of Massachusetts Medical School 24 Thomas Martin, MD Warren Alpert Medical School of Brown Joshua Roshal, MD University Rutgers Robert Wood Johnson Medical School Niyi Odewade, MD Harvard Medical School Ashley Siegel, MD University of Central Florida College Julia Song, MD of Medicine Harvard Medical School Sarah Tsou, MD Maya Srinivasan, MD University of California, San Francisco Icahn School of Medicine at Mount Sinai School of Medicine Avery Thompson, MD, MPH George Zhang, MD University of California, San Francisco Johns Hopkins University School of Medicine School of Medicine PGY 3 Bonnie Wong, MD, PhD, MSc Stanford University School of Medicine Isaac Alty, MD Harvard Medical School PGY 1 Ilaria Caturegli, MD Preliminary University of Maryland School of Medicine Lauren Anderson, MD James Etheridge, MD Rush University Medical College Eastern Virginia Medical School Jordan Forte, MD Eliza Hersh, MD Wake Forest University School of Medicine Icahn School of Medicine at Mount Sinai Kevin George, MD Paige Newell, MD Florida International University Herbert Lewis Katz School of Medicine at Temple Wertheim College of Medicine University Quinn Rainer, MD Sangki Oak, MD University of Miami Miller School of Medicine University of Pittsburgh School of Medicine

Alexander Ordoobadi, MD 2022 Graduates Brittany Powell, MD Harvard Medical School Stanford University School of Medicine Jamie Knell, MD Mehida Rojas-Alexandre, MD Surgical Critical Care Fellowship, USC Cullen Roberts, MD Yale School of Medicine Warren Alpert Medical School of Brown Pamela Lu, MD University Vanessa Welten, MD, MPH Surgical Oncology Fellowship, MD Anderson Northwestern University Feinberg School Cancer Center Max Riley, MD of Medicine Washington University School of Medicine Arin Madenci, MD PGY 4 Pediatric Surgery Fellowship, Boston Eva Rouanet, MD Children’s Hospital University of Massachusetts Medical School Rachel Atkinson, MD Geisel School of Medicine at Dartmouth David Mahvi, MD Sarabeth Spitzer, MD Surgical Oncology Fellowship, MSKCC Stanford University School of Medicine Sourav Bose, MD Perelman School of Medicine at the Danny Mou, MD Megan Sulciner, MD University of Pennsylvania MIS Fellowship, Emory University University of Minnesota Medical School Jessica Feliz, MD William Phillips, MD Matthew Vivero, MD University of Virginia School of Medicine Thoracic Surgery Fellowship, Brigham and Columbia University Vagelos College of Women’s Hospital Physicians and Surgeons Frances Hu, MD Emory University School of Medicine Rowza Rumma, MD Christine Wu, MD Vascular Surgery Fellowship, Weill Cornell University of Michigan Medical School James Luo, MD Medical Center University of Chicago Pritzker School of Biqi Zhang, MD Medicine Paul Salem, MD Harvard Medical School MIS Fellowship, Lahey Clinic Pooja Neiman, MD David Geffen School of Medicine at UCLA Research Cardiothoracic Surgery Integrated (I-6) Program Elizabeth Yates, MD Alexis Antunez, MD University of Michigan Medical School University of Michigan Medical School Program Director: Michael T. Jaklitsch, MD Bixiao Zhao, MD Jake Awtry, MD Associate Program Director: Yale School of Medicine Johns Hopkins University School of Medicine M. Blair Marshall, MD PGY 5 James Fitzgibbon, MD PGY 1 Lewis Katz School of Medicine at Temple Karan Chhabra, MD University Andrea Leibowitz, MD Rutgers Robert Wood Johnson Medical Columbia University Vagelos College School Annabelle Jones, MD of Physicians and Surgeons Renaissance School of Medicine at Stony Samuel Enumah, MD Brook University Maximilian Schloss, MD Johns Hopkins University School of Medicine Ludwig-Maximilians-Universität München, Katherine He, MD Germany Adam Fields, MD University of Michigan Medical School Icahn School of Medicine at Mount Sinai PGY 2 Patrick Heindel, MD Sameer Hirji, MD Keck School of Medicine of USC Phillip Allen, MD Johns Hopkins University School of Medicine Harvard Medical School Lenka Ilcisin, MD Joshua Jolissaint, MD Harvard Medical School Vivian Wang, MD University of Virginia School of Medicine Boston University School of Medicine Yun Jee Kang, MD Abby Larson, MD Harvard Medical School PGY 3 Johns Hopkins University School of Medicine Stefanie Soelling, MD Thais Faggion Vinholo, MD Laura Piechura, MD Emory University School of Medicine Yale School of Medicine Stanford University School of Medicine Kerri McKie, MD John Finnigan, Jr., MD Lily Saadat, MD University of Massachusetts Medical School Icahn School of Medicine at Mount Sinai Northwestern University Feinberg School of Medicine 25

PGY 5 Kathryn Marcus, MD Vinay Rathi, MD University of Iowa Carver College of Yale School of Medicine Morgan Harloff, MD Medicine Kaohsiung Medical University, Taiwan Research Obinna Nwosu, MD PGY 6 Indiana University School of Medicine Ryan Bartholomew, MD Harvard Medical School Farhang Yazdchi, MD Chloe Warinner, MD Shahid Beheshti University of Medical Harvard Medical School Lucy Xu, MD Sciences, Iran University of Chicago Pritzker School Allen Zhou, MD of Medicine Yifan Zheng, MD Harvard Medical School Boston University School of Medicine 2022 Graduates PGY 3 Research Eric Barbarite, MD Riu Han Liu, MD Facial Plastics and Reconstructive Ariana Bratt, MD Johns Hopkins University School of Surgery Fellowship, Thomas Jefferson University of California, San Francisco Medicine University Hospital School of Medicine Christopher McHugh, MD Adeeb Derakhshan, MD Patrick Gedeon, MD Wayne State University School of Medicine Facial Plastics and Reconstructive Surgery Duke University School of Medicine Fellowship, Johns Hopkins University Margaret Mitchell, MD Andreas Habertheuer, MD Vanderbilt University School of Medicine Suresh Mohan, MD Medical University of Vienna, Austria Facial Plastics and Reconstructive Danielle Reny, MD Surgery Fellowship, University of California, Hoda Javadikasgari, MD Perelman School of Medicine at the San Francisco Tehran University of Medical Sciences, Iran University of Pennsylvania Krupa Patel, MD Sue Wang, MD Isaac Wasserman, MD Pediatric Otolaryngology Fellowship, Lurie University of California, San Francisco Icahn School of Medicine at Mount Sinai Children’s Hospital of Chicago/Northwestern School of Medicine University PGY 4 Tiffany Wang, MD Otolaryngology Elliana DeVore (Kirsh), MD Laryngology Fellowship, Emory University Harvard Medical School Program Director, Harvard Oral Medicine Otolaryngology Residency Program: Krish Suresh, MD Stacey T. Gray, MD Harvard Medical School Program Director, Assistant Program Directors: Oral Medicine Residency Program: Alice Maxfield, MD; Kevin Emerick, MD Michael Wu, MD Piamkamon Vacharotayangul, DDS, PhD Harvard Medical School PGY 1 PGY 1 Roy Xiao, MD Hoang Bui Nguyen, MD Case Western Reserve University School Mandlin Al Mousa, BDS Perelman School of Medicine at the of Medicine King Saud University (DMSc program) University of Pennsylvania Phoebe Kuo Yu, MD Abdulrahman Nakshabandi, BDS Lillian Dattilo, MD Yale School of Medicine King Saud University (DMSc program) Harvard Medical School PGY 5 Laurel Henderson, DDS Geethanjeli Mahendran, MD University of Southern California Emory University School of Medicine Ciersten Burks, MD (certificate program) Indiana University School of Medicine Elizabeth Noyes, MD PGY 2 Harvard Medical School Lauren Miller, MD Perelman School of Medicine at the Lama Alabdulaaly, BDS, DMSc Edward Sim, MD University of Pennsylvania Saudi Arabia (certificate program) University of Pittsburgh School of Medicine Tara Mokhtari, MD Petros Yoon, DDS PGY 2 Stanford University School of Medicine University of Colorado Health Sciences Center (certificate program) Renata Knoll, MD Alan Workman, MD University of the Itajaí Valley Medical School, Perelman School of Medicine at the Brazil University of Pennsylvania 26

PGY 3 Ian McCulloch, MD 2022 Graduates West Virginia University School of Medicine Brittany Klein, DDS Jason Gardenier, MD University of North Carolina Adams School Ricardo Ortiz, MD Private Practice, Maine Plastic Surgery of Dentistry Harvard Medical School Center, Portland, ME Malak Al-Hadlaq, BDS PGY 4 Silviu Diaconu, MD Saudi Arabia (certificate and DMSc program) Private Practice, Northern Virginia Affiliates Brittany Caruso, MD in Plastic Surgery PGY 3 Research Lewis Katz School of Medicine at Temple University Timothy Irwin, MD Amal Bajonaid, BDS Hand Fellowship, Philadelphia Hand Saudi Arabia (certificate and MMSc program) Seth Fruge, MD to Shoulder Center Louisiana State University School 2022 Graduates of Medicine Dylan Perry, MD Reconstructive Microsurgery Fellowship, Yuanming Xu, DDS, MMSc Kimberly Khouri, MD Beth Israel Deaconess Medical Center Clinical Faculty, Tufts University School of New York University Grossman School Dental Medicine of Medicine Arman Serebrakian, MD, MS Hand Surgery Fellowship, UCLA Prazwala Chirravur, BDS PGY 5 (certificate program) Urology Clinical Faculty, University of Connecticut Olivia Ford, MD School of Dental Medicine Georgetown University School of Medicine Program Director: George Haleblian, MD Harvard Plastic Surgery Sarah Karinja, MD Columbia University Vagelos College PGY 1 Program Director, Harvard Plastic Surgery of Physicians and Surgeons Residency Program: Grayden Cook, MD Kyle Eberlin, MD Eric Wenzinger, MD University of Texas Southwestern Medical Associate Program Director: Medical University of South Carolina School Lydia Helliwell, MD PGY 6 Chiefs Thomas Hwang, MD Harvard Medical School Integrated Program Jason Clain, MD Tufts University School of Medicine Vanessa Lukas, MD PGY 1 Wake Forest University School of Medicine Brittany Vieira, MD Sri “Harsha” Malapati, MD Northwestern University Feinberg School PGY 2 Johns Hopkins University of Medicine Varnel Antoine, MD Eva Roy, MD Frankie Wong, MD Harvard Medical School University of Pittsburgh School of Medicine David Geffen School of Medicine at UCLA Christopher Magnani, MD Uriel Sanchez-Rangel, MD Independent Program Stanford University School of Medicine Stanford University School of Medicine Junior Residents Zhiyu (Jason) Qian, MD PGY 2 David Geffen School of Medicine at UCLA Eric Emberton, MD Ryoko Hamaguchi, MD University of Louisville School of Medicine PGY 3 Harvard Medical School Justin McCarty, MD Yefri Baez, MD Harriet Kiwanuka, MD Lake Erie College of Osteopathic Medicine University of Massachusetts Medical School Stanford University School of Medicine Chief Residents Vincent D’Andrea, MD Ogonna Nnamani Silva, MD Zucker School of Medicine at Hofstra/ University of California, San Francisco Ashley Ehret, MD Northwell School of Medicine Rutgers Robert Wood Johnson Medical School Kendrick Yim, MD PGY 3 University of California, San Diego School Vishwanath Chegireddy, MD of Medicine Charles Hwang, MD Morehouse School of Medicine University of Michigan Medical School 27

PGY 4 Aly Sherif, MD 2022 Graduates Boston University School of Medicine Brittany Berk, MD Kryston Boyer, DO University of Massachusetts Medical School 2022 Graduate Cardiothoracic Surgeon, Oklahoma State University Center for Health Sciences Catherine Gu, MD Jillian Angelo, MD Perelman School of Medicine at the Private Practice, Torrance Bariatric Institute, Darren Bryan, MD University of Pennsylvania Torrance, CA Faculty, Thoracic Surgery, University of Chicago Marie-Therese Valovska, MD Geisel School of Medicine at Dartmouth Paul Feingold, MD Faculty, Thoracic and Foregut Surgery, PGY 5 Breast Surgery Fellowship University of Rochester Tracy Han, MD Program Director: John Kuckelman, DO Duke University School of Medicine Tari King, MD Thoracic Surgeon, Dwight D. Eisenhower Associate Program Director: Army Medical Center at Fort Gordon Kevin Melnick, MD Olga Kantor, MD, MS Emory University School of Medicine Michael Lee, MD Charity Glass, MD Adult Cardiac Surgery and Endovascular Venkat Ramakrishnan, MD Harvard Medical School Cardiac Fellow, Brigham and Women’s University of Louisville School of Medicine Hospital Robert Pride, MD 2022 Graduates University of Central Florida College Cardiothoracic Surgery of Medicine Transplant Fellowship Erica L. Ditkoff, MD General Urology, Mass General Hospital, 2022 Graduate Program Director: Waltham Antonio Coppolino, III, MD Ashley Newman, MD Stephen W. Reese, MD Faculty, Penn Medicine Princeton Medical Bassem Ayyash, MD Urologic Oncology Fellowship, Memorial Center Lithuanian University of Health Sciences, Sloan Kettering Cancer Center Lithuania Gricelda Gomez, MD, MPH Cardiothoracic Surgery Colorectal Surgery Fellowship Kaiser Permanente, Northern California at Fellowship Vacaville Program Director: Program Director: Nelya Melnitchouk, MD, MSc Current Fellows Michael T. Jaklitsch, MD Associate Program Director: Naomi Sell, MD Acute Care Surgery Fellowship M. Blair Marshall, MD Sidney Kimmel Medical College at Thomas Jefferson University Program Director: PGY 6 Reza Askari, MD 2022 Graduate Julia Coughlin, MD Creighton University School of Medicine Miquell Miller, MD Stanford University of Medicine Crystal Kyaw, MD Ross McFall, MD Zucker School of Medicine at Hofstra/ McGovern Medical School at the University BWH/MGH Harvard Combined Northwell of Texas Health Science Center at Houston Endocrine Surgery Program 2022 Graduate William Phillips, MD Program Director: Rush University Medical Center Matthew A. Nehs, MD Mohammad (Reza) Afrasiabi, MD Associate Surgeon, Division of Trauma, PGY 7 Lauren Krumeich, MD Burn and Surgical Critical Care, Brigham Yale School of Medicine and Women’s Hospital Leonid Belyayev, MD Uniformed Services University F. Edward 2022 Graduate Advanced Laparoscopic Hébert School of Medicine Fellowship Alessandra Moore, MD Samuel Freyaldenhoven, MD Faculty, University of Rochester School of Program Director: University of Arkansas College of Medicine Medicine Ali Tavakkoli, MD Associate Program Director: Borami Shin, MD Eric Sheu, MD, PhD University of California, San Diego School of Medicine 28

Endovascular and Adult Cardiac Surgical Critical Care Fellowship PGY 7 Surgery Fellowship Program Director: Zhi Fong, MD Program Director: Reza Askari, MD Sidney Kimmel Medical College at Thomas George Tolis Jr., MD Associate Program Director: Jefferson University Kristin Sonderman, MD, MPH Michael Lee, MD 2022 Graduate University of Pittsburgh School of Medicine Matthew Bartek, MD University of Massachusetts Medical School Thinzar Lwin, MD Clauden Louis, MD Attending Surgeon, City of Hope National Howard University School of Medicine Megan Chan, MD Medical Center Icahn School of Medicine at Mount Sinai Osama Haddad, MD Cairo University School of Medicine, Egypt Leo Lin, MD Urological Oncology Fellowship University of Illinois Rockford College 2022 Graduate of Medicine Program Director: Steven L. Chang, MD, MS William Shi, MD Thomas Mitchell, MD Faculty, Northwell Health System University of Miami Miller School of Medicine First-Year Fellows General Thoracic Surgery 2022 Graduates Jillian Egan, MD Fellowship SUNY Upstate Medical University Adam Golden, MD Program Director: Faculty, NYU Langone Health Benjamin Stone, MD Michael T. Jaklitsch, MD Weill Cornell Medicine Crystal Kyaw, MD Tyler Draeger, MD Acute Care Surgery Fellowship, Brigham and Second-Year Fellows American University of the Caribbean Women’s Hospital School of Medicine Ikena Madueke, MD Constantine Saclarides, MD University of Illinois College of Medicine Reginald Chounoune, MD Trauma Surgery Fellowship, Ryder Trauma Howard University School of Medicine Center at University of Miami/Jackson Affan Zafar, MD Memorial Medical Center Baylor College of Medicine 2022 Graduate Stephanie Yee, DO 2022 Graduates Roger Zhu, MD Faculty, NewYork-Presbyterian Queens/Weill CT Surgery Fellowship, Albert Einstein Cornell Medicine Filipe de Carvalho, MD College of Medicine, Montefiore Medical Associate Surgeon, Division of Urology, Center Surgical Clinical Nutrition Brigham and Women’s Hospital Support Fellowship Minimally Invasive Thoracic Madhur Nayan, MD Surgery Fellowship Program Director: Associate Professor of Surgery, Malcolm Robinson, MD New York University Program Director: Jon O. Wee, MD Tina Bharani, MD Vascular Surgery Fellowship Weill Cornell Medicine-Qatar Mohammad Abdallat, MD Program Director: University of Jordan School of Medicine 2022 Graduate Matthew Menard, MD Associate Program Director: Carlos Soriano, MD Kanwal Bains, MD Marcus Semel, MD Augusta University/University of Georgia Clinical Assistant Professor, Banner - Medical Partnership University Medical Center Tucson PGY 6 2022 Graduates Surgical Oncology Fellowship Brittany Aicher, MD New York Medical College Daniel Solomon, MD Program Director: General Surgeon, Rabin Medical Center, Mark Fairweather, MD Bernadette Goudreau, MD Tel Aviv, Israel University of Virginia School of Medicine PGY 6 Sandeep Sachidananda, MD Rebecca Scully, MD Fellow, WVU Heart and Vascular Institute Raya Narayan, MD Geisel School of Medicine at Dartmouth University of California, Irvine School of Medicine 29

PGY 7 Joseph E. Murray Visiting Professor in Announcements Transplant Surgery Bryan Dieffenbach, MD Jayme E. Locke, MD, MPH, FACS, FAST Geoffrey Anderson, MD, MPH, University of California, San Diego School University of Alabama at Birmingham Named General Surgery Residency of Medicine Hospital Associate Program Director for Resident Research Development 2022 Graduates Gordon C. Vineyard Lecturer in Surgery Jay J. Schnitzer, MD, PhD Dr. Anderson graduated from Duke Andrew Servais, MD The MITRE Corporation University with a BS in biology and Vascular Surgeon, Winchester Hospital, religion. He obtained an MPH at the Winchester, MA Dorothy R. Eisenberg Lecturer in Harvard T.H. Chan School of Public Surgery Health and his medical degree from Rebecca Scully, MD John C. Alverdy, MD, FACS the Emory University School of Faculty, Dartmouth Medical Center University of Chicago Medicine. He completed a general surgery residency at Massachusetts Visiting Professors Gelman-Zinner Visiting Professor in General Hospital and a trauma Surgery, Anesthesiology, Perioperative and critical care fellowship at the Gerald and Elaine Schuster and Pain Medicine University of Southern California Distinguished Lecturer in Thoracic Michael W. Mulholland, MD, PhD Medical Center. Surgery University of Michigan Medicine Haiquan Chen, MD Dr. Anderson is board certified in Fudan University Shanghai Cancer Center John A. Mannick Visiting Professor in general surgery and surgical critical Vascular Surgery care. He previously served in the Air David J. Sugarbaker Lecturer in Richard J. Powell, MD Force as a flight surgeon and was Thoracic Surgery Dartmouth-Hitchcock Medical Center deployed to Iraq and Afghanistan, Young Tae Kim, MD, PhD where his main role was to evacuate Seoul National University Hospital Francis D. Moore Pro Tempore Visiting casualties from the battlefield on Professor in Surgery rotary and fixed wing aircraft. He Joseph E. Murray Visiting Professor in Robert Higgins, S.D, MD, MSHA also assisted in the ER and OR Plastic Surgery Brigham and Women’s Hospital during numerous mass casualty Babak J. Mehrara, MD events and assisted with the H1N1 Memorial Sloan Kettering Cancer Center Richard E. Wilson Visiting Professor in outbreak in Afghanistan. Surgical Oncology Hechtman Trauma Lecturer in Surgery Suzanne L. Topalian, MD Dr. Anderson’s clinical and Avery B. Nathens, MD, PhD, FRCS, FACS Johns Hopkins University School of research interests include global University of Toronto Medicine surgery, the social determinants of traumatic diseases, implementation Lawrence H. Cohn Visiting Professor in Nina S. Braunwald Lecturer in Surgery science and surgical education. Cardiac Surgery Jolanda Kluin, MD Joseph Woo, MD Amsterdam University Medical Center Stanford University School of Medicine Follow the Brigham Surgery Residents on Instagram! 30

Research Brigham and Women’s Hospital is an international powerhouse in biomedical research dedicated to pioneering discoveries that will translate into new prediction methods, treatments, and cures for the world’s most devastating and complex diseases. 513 410 44 active protocols research funds active clinical trials 32 179 research fellows active grants and contracts $40,683,510 research spending Elizabeth Mittendorf, MD, PhD, with both response and toxicity to local resources and economies of Awarded a $1.9M Breast Cancer immunotherapy. Our goal is to elucidate scale to cultivate an integrated set of Alliance Grant these factors. research tools to serve JBC members. Next- generation sequencing tools Drugs designed to augment the James Lederer, PhD, Awarded include single-cell RNAseq, CITE-seq, immune response against breast a $1.3M National Institutes of ATAC-seq, T-scan, PhIP-seq, and spatial cancer are now approved for routine Health Grant transcriptomics, while protein-based use in the preoperative setting for services include CyTOF, tissue mass patients diagnosed with early-stage Understanding inflammatory arthritis cytometry, and custom Luminex, all triple negative breast cancer. While and related diseases requires access analyzed with assistance and education these drugs result in increased rates to high-quality biosamples and to from the new JBC Bioinformatics Core. of pathologic response and improved increasingly sophisticated experimental survival, they are associated with and analytical tools. The Joint Biology Li Jia, PhD, Awarded a $2M toxicities in approximately 45% of Consortium represents the collective National Institutes of Health patients receiving this treatment. effort of a network of more than Grant Therefore, there is a critical need to 70 researchers from 18 centers to better understand immune aspects overcome logistical challenges together Prostate cancer is the second leading of the tumor microenvironment, as in order to build a powerful engine of cause of cancer death in American well as the immune cells circulating translational research in rheumatology men, behind only lung cancer. Despite in a patient’s blood in order to and orthopedics. The Cellular Systems major therapeutic advances, metastatic identify factors that are associated Core led by Dr. Lederer will leverage castration-resistance prostate cancer 31

as a form of advanced prostate cancer Jennifer Guerriero, PhD, Awarded Selected Grants remains incurable. The goal of this a $2.3M National Institutes of study is to develop a novel therapeutic Health Grant Neo-TRIBUTE (Translational resource approach to overcome the failure for immuno-biology to understand of current clinically used androgen Tumor associated macrophages therapeutic efficacy) receptor-targeted therapies in the (TAMs) are highly suppressive in the PI: Elizabeth Mittendorf, MD, PhD treatment of this lethal disease. tumor microenvironment (TME) and Sponsor: Breast Cancer Alliance contribute to chemo- and immuno- Grant Amount: $1,967,110 Zara Cooper, MD, MSc, Awarded therapy resistance. Our lab has made a $3.5M National Institutes of the discovery that a commonly used Cellular systems core 2 Health Grant cancer therapy, PARP inhibitors PI: James Lederer, PhD (PARPi), induce lipogenic metabolism Sponsor: NIH Over 1 million older adults with in TAMs rendering them even more Grant Amount: $1,354,771 serious illness have major surgery or suppressive, in which they inhibit severe trauma each year, and palliative T-cell function and activation, and limit Androgen receptor pathway inhibition care delivered alongside surgical care therapeutic responses; importantly, through targeting PARP-2 in can help relieve patient suffering, however, in the absence of TAMs, castration-resistant prostate cancer improve postoperative outcomes and PARPi promotes metabolically PI: Li Jia, PhD reduce health care utilization. Although superior T-cell antitumor traits. Our Sponsor: NIH seriously ill surgical patients benefit proposal will formally determine how Grant Amount: $2,039,125 from palliative care, they are less lipogenic TAM and T-cell metabolism is likely than other patients to receive regulated during PARPi therapy, which A layered examination of the patient it. The proposed study will provide an is likely to provide opportunities for experience to elucidate the role of innovative and layered examination the development of novel treatment palliative care in surgical care for of the role of palliative care in surgery strategies that hold the power to seriously ill adults to directly inform bedside clinical overcome the immune-suppressive PI: Zara Cooper, MD, MSc decisions and the implementation of TME and improve PARPi therapy Sponsor: NIH targeted palliative care interventions Grant Amount: $3,526,123 to improve care for older seriously ill success in a number of cancer types. surgical patients. Immunometabolic pathways enabled by PARP inhibition in breast cancer PI: Jennifer Guerriero, PhD Sponsor: NIH Grant Amount: $2,359,833 Selected Clinical Trials Percutaneous or surgical repair in mitral prolapse and regurgitation for >/_ 65-year-olds PI: Mark Cunningham, MD Sponsor: NIH/NHLBI CHIO3 Trial: CHemotherapy combined with immune checkpoint inhibitor for operable stage IIIA/B non-small cell lung cancer PI: Abby White, DO Sponsor: Alliance Foundation Trials A phase II multi-institutional trial to evaluate PSMA-based PET imaging of high-risk prostate cancer PI: Mark Preston, MD, MPH Sponsor: NCI via Westat A prospective, multi-center investigation of the da Vinci SP® Surgical System in pulmonary lobectomy and thymectomy for benign and malignant disease (NOTE: BWH did the first case in the country) PI: M. Blair Marshall, MD Sponsor: Intuitive 32

Center for Surgery and Public Health (CSPH) Making surgery safer, more patient-centered, and more accessible in the U.S. and around the world. At the Center for Surgery and Public research, explore new collaborations improve access to palliative care for Health (CSPH), a diverse coalition of and discuss solutions focused on older seriously ill surgical patients, surgical health services researchers language equity for the Greater Boston aligning system-level change with examines and challenges how surgical Area. Led by Juan Herrera-Escobar, the patient experience. New studies care is accessed, delivered and MD, MPH, and Geoffrey Anderson, in palliative and geriatric surgery will experienced. For almost 20 years, CSPH MD, MPH, the Non-English-Speaking examine the obstacles surgical patients has set the standard for surgical health Trauma Survivors (NESTS) Pathway—a face accessing palliative care, detail services research, training over 100 Mass General Brigham United Against how structural racism may impact leaders in academic surgery, producing Racism initiative—is actively enrolling access to this care and improve over 1,400 peer-reviewed publications patients to take part in its novel how current system-level guidance and receiving over $25 million in screening and support system this year. addresses these issues. grants. This year our center continues Under this new system, a specialized to grow, expanding our catalog of community health worker evaluates Through our global programs and national and state-level health services patients undergoing trauma surgery established partnerships, we have data, developing our talented team of for symptoms of depression, anxiety responded to crises and helped quantitative and qualitative methods or post-traumatic stress disorder, links strengthen access to high quality experts, and welcoming Louis L. them to health system and community surgical education. At the request of Nguyen, MD, MBA, MPH, as our new resources and provides ongoing support the Ministry of Health of Ukraine, Nelya research fellowship director. Together, navigating their recovery. Melnitchouk, MD, MSc, and Geoffrey our research spans the entirety of the Anderson, MD, MPH, are working with surgical care delivery pathway, united The shared decision-making process the Harvard Humanitarian Initiative in a commitment to safe, high quality, among clinicians, patients and their to translate trauma course materials equitable, and patient-centered care. caregivers is paramount to aligning into Ukrainian and to deliver two-week treatment plans—including whether to intensive trauma courses to local For 17.4% of Bostonians, limited have surgery or communicating end- physicians in five cities in Ukraine. In English proficiency (LEP) reduces of-life care goals—with patient goals, Rwanda, Robert Riviello, MD, MPH, access to health care and may lead especially for seriously ill and older and a team of dedicated international to poor outcomes. To address health patients. Joel Weissman, PhD, and his and local surgical faculty led the first system inadequacies exposed by this team have built on their previous work surgical clerkships for medical students inequity, CSPH has expanded its efforts on advance care planning and surgical at the University of Global Health Equity. to advance language concordant care. decision making to examine how the As recent medical school graduates In the spring, Gezzer Ortega, MD, MPH, process is experienced by marginalized are expected to engage in surgical held the inaugural Boston Language groups. Recently published work care delivery during their service in Equity meeting, convening researchers, highlights how experienced and rural hospitals, practical experience in clinicians, interpreters and policy perceived bias from the health care essential surgical care is a vital part of advocates throughout the city to share system may cause sex and gender their medical education. A new recipient minority patients to delay or avoid of a Burke Global Health Fellowship end-of-life care discussions with grant, Kavitha Ranganathan, MD, is their health care provider, resulting in examining the incidence and impact discordant care. A new study is focused of financial hardship due to medical on understanding how patients living expenses resulting from trauma with dementia make decisions about among marginalized patients in the U.S. surgical care and empowering these and India. patients to have greater involvement in their own health care decisions with From health system design to patient- their care teams through new shared centered care delivery, we remain decision-making tools. Zara Cooper, committed to high quality research MD, MSc, has continued her work to that serves patients here in Boston and around the world. 33

Grant Highlights in surgical care for seriously ill adults grant for her project, “Locoregional (Diversity Supplement).” Over 1 million treatment decision-making in older adults Rachel Adler, ScD, was awarded a older adults with serious illness have with early-stage, hormone receptor- $120,000 grant from the Alzheimer’s major surgery or severe trauma each positive breast cancer.” Older adults with Association for her project, “Outcomes year, and palliative care delivered early-stage HR+ breast cancer must and quality of life for people with alongside surgical care can help relieve factor geriatric-specific concerns into dementia facing surgery.” This parallel patient suffering, improve postoperative the multiple patient-sensitive treatment mixed methods proposal aims to fully outcomes and reduce health care decisions that they face, but little is describe the expected outcomes of utilization. Although seriously ill surgical known about how physicians can best surgery for people living with dementia patients benefit from palliative care, support these patients through the (PLWD), as well as the considerations they are less likely than other patients decision-making process. evaluated by PLWD and their families to receive it. The proposed study will when facing decisions about surgery. provide an innovative and layered Gezzer Ortega, MD, MPH, was awarded They will use national Medicare data examination of the role of palliative a $860,000 NIH career development (currently available onsite) to describe care in surgery to directly inform grant for his project, “Improving the epidemiology of surgery for PLWDs bedside clinical decisions and the outcomes for Spanish-speaking and inform decision-making and implementation of targeted palliative surgical patients with limited English expectations about outcomes. care interventions to improve care for proficiency.” This study will utilize older seriously ill surgical patients. This quantitative and qualitative methods Zara Cooper, MD, MSc, was awarded grant has been awarded an additional to evaluate social factors, facilitators a $280,000 grant from the John A. $280,000 diversity supplement to and barriers, and surgical outcomes for Hartford Foundation for her work with examine barriers to implementation of patients with limited English proficiency the American College of Surgeons perioperative care in clinical practice. (LEP). Findings of this research and evaluating and improving the Geriatric the evaluation of a mobile medical Surgery Verification (GSV) program. Zara Cooper, MD, MSc, was awarded interpretation application deployed The GSV program was designed to a $175,000 NIH grant for her project, to patients with LEP will be used to provide a framework for the optimal “Structural racism and engagement of design and implement future scalable care of the geriatric surgical patient, family caregivers in serious illness care” interventions built with patient-centered generalizable to over 4,000 facilities in partnership with UMass Medical communication and mitigating negative regardless of size, location, population School. An estimated 12 million U.S. social factors at the core across U.S. served or teaching status. The adults are living with serious illness, hospitals for maximum impact. proposed evaluation of how the GSV is a condition that carries a high risk functioning in the real world will provide of mortality and excessively strains Joel Weissman, PhD, was awarded two the information necessary to adjust their caregivers. Structural racism and NIH supplement grants ($360,000) to and align the standards, as indicated, racial/ethnic residential segregation expand on the study, “Understanding to improve content and facilitate may affect health care for patients with and improving surgical decision- implementation, thereby making serious illness by limiting access to making for persons living with dementia systematic, optimal geriatric surgical palliative care, the specialty focused (PLWDs), their family caregivers, and care available to all older adults across on improving quality of life for persons their providers: A mixed methods study.” the United States. with serious illness and their families The new studies will examine long-term and limiting the capacity of family outcomes for PLWDs after surgery Zara Cooper, MD, MSc, was awarded a caregivers to engage with the health and allow for a deeper examination $3.2M NIH grant for her study, “A layered care system. This population-based, of the epidemiology of surgery and examination of the patient experience multi-level, mixed-methods study will challenges of surgical decision-making to elucidate the role of palliative care be conducted within and across the for Hispanic PLWDs. state of Massachusetts to disentangle the relationships among residential Joel Weissman, PhD, was awarded a segregation, neighborhood deprivation $2.1M grant from the Henry M. Jackson and health care utilization in serious Foundation for the Advancement of illness to provide evidence that racism, Military Medicine, Inc. for the study, not patient mistrust, is a primary barrier “Military health system response to to equitable palliative care and health COVID-19: A health services research outcomes. approach to sustainable process improvement” in partnership with the Christina Minami, MD, MS, was awarded Uniformed Services University of the a $258,000 NIH career development Health Sciences. 34

Patient-Reported Outcomes, Value & Experience(PROVE) Center Founded in 2018 by Dr. Andrea Pusic, the mission of the Patient-Reported Outcomes, Value and Experience (PROVE) Center is to expand the collection, analysis and use of patient- reported outcomes data in clinical care. The PROVE Center focuses on using innovative techniques to study outcomes that matter most to patients and their caregivers. PROVE researchers specialize in qualitative and quantitative research methods, evidence synthesis, psychometrics (including computer adaptive testing) and health economic evaluations. With these skills, our multidisciplinary team aims to promote and operationalize high-value, patient-centered care at Mass General Brigham, and around the world. 35

Year at a Glance to continuing our ongoing support to continues to grow in its numbers of clinician-researchers, this year PROVE recruited patients and centers. The We are excited to welcome Jason Liu, Center faculty contributed to the first study aims to scale and spread the MD, MPH, to our leadership team. He is annual Mass General Brigham Patient routine, health IT-enabled collection a specialized endocrine surgeon with Reported Outcome Measures (MGB of PROs from ambulatory surgical a strong interest and experience in PROMS) abstract competition planning patients. To date, over 12,000 patients patient-reported outcomes in surgical committee and provided analytic in 64 centers have contributed data, an care. He has previously worked with support to two of the selected abstract increase from 2,400 patients and 34 Dr. Pusic on PROMs-related projects teams. centers at this time last year. and will be contributing to our projects, decision-making and smaller working In July of 2021, the PROVE Center PROVE Center faculty, in collaboration groups within the center to help with its launched imPROVE, an innovative with the MGB PROMS team, is using growth. electronic Patient-Reported Data (PRD) data collected from millions of patients collection platform, within the breast through the MGB PROMS program to We have expanded our support this oncology and plastic surgery services investigate the intersection of social year, adding a new program manager, at Dana-Farber Cancer Institute (DFCI) determinants of health and social risk project manager, statistical analyst and and Brigham and Women’s Hospital, factors with patient-reported outcomes, research assistant. We also supported respectively. Since the July launch, surgical access and clinical outcomes. one research year medical student on we have collected over 2,400 PROMs staff this past year and three summer across 34 provider clinics. Development Other ongoing PROVE Center research trainees. of imPROVE 2.0, a more accessible projects: mobile friendly web-based platform PROVE Center faculty have published with EPIC integration and other feature • Development of a patient-reported 65 papers in peer-reviewed journals upgrades, is nearly complete and will be outcome measure for total related to patient-reported outcome deployed this coming fall. laryngectomy (LARY-Q) measure (PROM) development and implementation and comparative We continued our work on development • Development and content validity of effectiveness studies that use PROMs to and implementation of a patient- new BREAST-Q scales to measure the evaluate outcomes. reported outcome measure for gender- experience of Breast Implant Illness affirming treatments (GENDER-Q), We hosted the PROVE Summer School completing a pilot field test study of the • Development of a condition-specific for the third year in a row, increasing measure with a sample of 602 gender patient-reported outcome measure our registered participants by about diverse research participants from 28 for patients with chronic headaches 100 individual providers, researchers countries in the Prolific platform. The and students around the world. The GENDER-Q international field test study • Evaluating cold sensitivity following summer school hosts five weekly is now underway and has recruited 1,900 autologous and implant-based breast Zoom lectures from leading experts in participants since field study start on reconstruction using patient reported the field of PROMs development and April 2022. outcomes and infrared thermal implementation. imaging The center’s AHRQ-funded R18 grant in The PROVE Center PROMs Research collaboration with the American College • Prepectoral versus subpectoral LaunchPad consultant service had of Surgeons, Scaling and spreading reconstruction: A cost-effectiveness another successful year supporting electronic capture of patient-reported analysis clinicians and researchers in PROM- outcomes using a national surgical related research projects. In addition quality improvement program (NSQIP), • Improving outcomes for surgical patients with limited English proficiency 36

News Faculty News & Notes Nancy Cho, MD, was named poster & Notes chair for the American Association of Shailesh Agarwal, MD, was selected as Endocrine Surgery (AAES) Program New Endowed Chairs a Society of Asian Academic Surgeons Committee. (SAAS) Visiting Professor for the 2022- Matthew J. Carty, MD 2023 academic year and received the Alexander Cole, MD, was a recipient Roberta and Stephen R. Weiner SAAS Visiting Professor Lectureship of the Brigham 2022 Bruce A. Beal and Distinguished Chair in Surgery Award; and was awarded The Plastic Robert L. Beal Surgical Fellowship. Surgery Foundation Pilot Research Thomas E. Clancy, MD Grant. Zara Cooper, MD, MSc, was awarded Distinguished Scholar in Surgical the Brigham and Women’s Physicians Oncology Geoffrey Anderson, MD, MPH, was Organization Diversity and Inclusion appointed as a flight commander and Service Pillar Award; was accepted Michael T. Jaklitsch, MD the director of Medical Operations for into the Executive Leadership in Health Jack Mitchell Distinguished Chair in the 439 Aeromedical Staging Squadron, Care (ELH) Program; was inducted into Thoracic Surgery Westover Air Reserve Base; and the American Surgical Association was appointed visiting faculty at the (ASA); and was appointed as a member Adam S. Kibel, MD University of Global Health Equity. of the American College of Surgeons DiNovi Family Distinguished Chair in Committee on Trauma (ACS COT). Urology Stanley Ashley, MD, was awarded the Brigham and Women’s Physicians Paul Davidson, PhD, was named Scott J. Swanson, MD Organization Senior Faculty Mentor president-elect of the American Society Canepari Family Distinguished Chair in Pillar Award; was named chair of the for Metabolic and Bariatric Surgery Thoracic Surgery Society for Surgery of the Alimentary (ASMBS) Integrated Health Section. Tract (SSAT) Foundation; and was Faculty Promotions and honored as the dedicatee of the Owen Laura S. Dominici, MD, led Dana-Farber Appointments Wangensteen Scientific Forum at the Brigham Cancer Center through a 2021 American College of Surgeons successful Commission on Cancer Professor (ACS) Clinical Congress. accreditation visit as the Cancer Zara Cooper, MD, MSc Liaison Physician; was named chair Doug Smink, MD, MPH Regan Bergmark, MD, was named the of the Society of Surgical Oncology Sook Bin Woo, DMD, MMSc Brigham H. Richard Nesson Fellow for (SSO) Continuing Medical Education her project, “Disparities in timely access Committee; was named a member of Associate Professor to quality surgical care at Brigham the SSO International Conference on Laura Dominici, MD Health and in the Boston community;” Surgical Cancer Care Scientific Program Maria Edelen, PhD and was awarded a Pillars of Excellence Committee; and was named a member Indranil Sinha, MD Award for work in the category of of the American Society of Clinical Integrating Diversity, Equity & Inclusion. Oncology Annual Meeting Scientific Assistant Professor Program Committee Breast Cancer Geoffrey Anderson, MD, MPH Monica M. Bertagnolli, MD, was elected Track. Regan Bergmark, MD as a member of the National Academy Zi Chen, PhD, MA of Medicine (NAM). Neil Gushe, MD, was elected to the Alexander Cole, MD council of the Massachusetts Chapter Juan Garisto, MD Thomas Carroll, MD, was awarded of the American College of Surgeons. Hassan Khalil, MD the Journal of Voice Best Paper Award Olga Kantor, MD, MS in Clinical Medicine for the article, Lydia A. Helliwell, MD, received the Nakul Raykar, MD, MPH “Safer singing during the SARS-COV-2 Resident Teaching Award at the Harvard Eleni Rettig, MD pandemic: What we know and what Plastic Surgery Residency Training Jamie Robertson, PhD, MPH we don’t.” Program resident graduation; and was Ashraf Sabe, MD awarded the Brigham Distinguished Kristin Sonderman, MD, MPH Zi Chen, PhD, was selected as one of Clinician Award. Daniel A. Wollin, MD, MS the finalists in the Biomedical Advanced Research and Development Authority Kentaro Ikeda, DDS, MPH, was named (BARDA) Mask Innovation Challenge vice president of the American Academy Phase II. of Oral Medicine (AAOM). 37

Jennifer Irani, MD, was elected to Faina Nakhlis, MD, was installed as Career Development Award; received membership on the Harvard Medical secretary of the Massachusetts Chapter the 2022 Harvard Medical School School/Harvard School of Dental of the American College of Surgeons. Scholarly Engagement Excellence in Medicine Faculty Council. Mentoring Award; and received the 2022 Matthew Nehs, MD, was awarded the NIH NIMHD Loan Repayment Program Kamal MF Itani, MD, was featured in 2022 Brigham Department of Surgery Award. the Bulletin of the American College Richard E. Wilson Award and the Joseph of Surgeons; and was recognized by E. Murray and Simon J. Simonian Kavitha Ranganathan, MD, was Stanford University as a top 2% most Award. awarded the 2022 American Medical influential scientists (according to most Association (AMA) Women Physicians cited papers) in a study published by Louis Nguyen, MD, MBA, MPH, was Section (WPS) and the AMA Foundation Elsevier. named fellowship director of the Joan F. Giambalvo Fund for the Brigham Center for Surgery and Public Advancement of Women; was elected Olga Kantor, MD, MS, was appointed Health Research Fellowship; and was vice president of the American Society chair of the Society of Surgical the recipient, along with Elizabeth Yates, of Plastic Surgeons (ASPS) Young Oncology (SSO) Fellows & Young MD, PGY-4, of a Brigham Care Redesign Plastic Surgeons (YPS) Forum; received Attendings Subcommittee; and received Incubator and Startup Program The Plastic Surgery Foundation (PSF) the Dana-Farber Cancer Institute Susan (BCRISP) award for “Watching Our National Endowment for Plastic Surgery F. Smith Center for Women’s Cancers Waste (WoW). Grant for the project titled, “Financial Innovation Grant. hardship after surgery: A mixed- Devin M. O’Brien-Coon, MD, MSE, was methods, multicenter study in India;” Pardon Kenney, MD, MS, was awarded the recipient of the 2022 American was awarded the National Institute the Brigham and Women’s Physicians Association of Plastic Surgeons/ LGBTQIA+ Health Education Center Organization Clinical Teacher Pillar Furnas Academic Scholarship Award Advancing Excellence in Transgender Award; was an invited named lecturer for the project, “Androgenic steroid Health Conference Scholarship; was for the annual Kenneth Warren lecture modulation of tissue repair and fibrosis;” awarded the Fenway Institute Best at New England Baptist Hospital; was awarded the NIH Boston Pepper Presentation Award in the Research & and was the course director for the Center Exploratory Studies Grant Technology Session; and was awarded Comprehensive Review of General for the project, “Reversing aging- the American Society of Plastic Surgery at Oakstone Medical induced wound healing dysfunction via Surgeons Top Clinical Research Poster Publishing. androgen-estrogen axis modulation;” in the Socioeconomic Section. joined the Plastic and Reconstructive Adam S. Kibel, MD, was elected as Surgery editorial board; and was Erika Rangel, MD, MS, was a recipient the secretary of Society of Urologic named chair of the American Society of the 2021 Office of Professional Oncology (SUO); was the Caulk Visiting of Plastic Surgeons (ASPS) Gender Development Outstanding Citizenship Professor at Washington Affirming Surgery Residency Curriculum Award; and was the Brigham Surgery University in St. Louis; and was Committee. representative in the Assistant the recipient of the 2021 Jack Professor Exchange Program with the Colbert Memorial Award from the Dennis P. Orgill, MD, PhD, was the University of Michigan. Massachusetts Prostate Cancer American Association of Plastic Coalition (MPCC). Surgeons (ASPS) Visiting Professor, Chandrajit P. Raut, MD, MSc, was visiting 10 programs across the country; awarded an RO1 NIH grant for his Elizabeth Mittendorf, MD, PhD, began and he gave a keynote address at the project titled, “Supratherapeutic term as treasurer for the American International Confederation of Plastic PTX buttresses reduce locoregional Society of Clinical Oncology; was Surgery Societies (ICOPLAST) First recurrence rates following surgery for awarded a prestigious grant from the Word Congress in Lima, Peru. soft tissue sarcomas;” and presented Breast Cancer Research Foundation grand rounds as the 2022 Edward to study the use of preoperative Gezzer Ortega, MD, MPH, received J. Tabah Visiting Surgical Oncology immunotherapy in breast cancer a National Institutes of Health (NIH) Professor at McGill University in patients; and was selected to serve National Institute on Minority Health Montreal, Quebec, Canada. on the National Cancer Institute (NCI) and Health Disparities (NIMHD) K23 Breast Cancer Steering Committee award for his project entitled, “Improving Scott Shikora, MD, was awarded (BCSC) Breast Oncology Local Disease outcomes for Spanish-speaking surgical the Mass General Brigham Pillars of (BOLD) Task Force. patients with limited English proficiency;” Excellence Award in the category of received the 2022 BWH Center for Advancing Innovation & Progress. Diversity and Inclusion Minority Faculty 38

Brent Shoji, MD, was awarded the Nathaniel Treister, DMD, DMSc, was Jeremy Wolfe, PhD, was awarded Brigham Distinguished Clinician Award; named president of the American the Clifford T. Morgan Distinguished and was the recipient of the 2021 Academy of Oral Medicine (AAOM); and Leadership Award by the Psychonomic Outstanding Clinical Teacher Award for was awarded the AAOM Samuel Charles Society; and gave the Keynote Address Mass General Brigham. Miller Lecture Award. at the 9th Conference on Cognition Research of the Israeli Society for Doug Smink, MD, MPH, was awarded Quoc-Dien Trinh, MD, was awarded Cognitive Psychology (ISCOP). the Brigham Department of Surgery the Brigham Outstanding Citizenship Joseph E. Murray and Simon J. Award; and was awarded the American Daniel Wollin, MD, received a Footbridge Simonian Award; and was inducted Urological Association (AUA) Young Grant from the MIT Koch Institute for into the American Surgical Association Urologist of the Year Award for the New Integrative Cancer Research (KI) (ASA). England Section. and the Dana-Farber/Harvard Cancer Center (DF/HCC) Bridge Project. Ali Tavakkoli, MD, was named vice Thomas C. Tsai, MD, MPH, was chair of the American College of awarded a Future of Privacy Forum James Yoo, MD, was awarded the Surgeons Committee for the Owen H. (FPF) award for Research Data Research in Progress Award at the Wangensteen Scientific Forum; and was Stewardship as part of a team that American Society of Colon and Rectal the program chair for the 2022 New partnered with Google Health. Surgeons (ASCRS) Annual Meeting; and England Surgical Society (NESS) Annual received the Limited Project Grant from Meeting. Stefan G. Tullius, MD, PhD, was elected the Research Foundation of the ASCRS. vice president of The Transplantation George Tolis, Jr., MD, was awarded Society (2022-2026); and was awarded Marco A. Zenati, MD, was appointed the Socrates Award from the Thoracic the Dr. HL Trivedi Oration Award co-chair of the National Institutes of Surgery Residents Association (TSRA). from the Indian Society of Organ Health Bioengineering, Technology Transplantation (ISOT). and Surgical Sciences (BTSS) Study Section. Top Doctors Boston Magazine’s 2022 “Top Doctors” issue recognizes 53 Department of Surgery faculty members this year. Congratulations to the following providers for being recognized as the best in their respective fields: Colon and Rectal Christian Sampson, MD Thoracic and Cardiac Vascular Surgery Surgery (Hand Surgery) Surgery Michael Belkin, MD Ronald Bleday, MD Simon Talbot, MD Raphael Bueno, MD Edwin Gravereaux, MD Joel Goldberg, MD, MPH Christopher Ducko, MD Matthew Menard, MD James Yoo, MD Surgery Tsuyoshi Kaneko, MD Charles Ozaki, MD Hari Mallidi, MD Otolaryngology Stanley Ashley, MD M. Blair Marshall, MD The following board- Monica Bertagnolli, MD Ciaran J. McNamee, MD certified Brigham Oral Donald Annino, MD Thomas Clancy, MD Steven Mentzer, MD Medicine specialists were Thomas L. Carroll, MD Laura S. Dominici, MD Daniel E. Rinewalt, MD included in Boston Carleton E. Corrales, MD Gerard Doherty, MD Scott Swanson, MD Magazine’s 2022 Laura A. Goguen, MD Atul Gawande, MD George Tolis, MD “Top Dentists” list: Alice Z. Maxfield, MD Pardon Kenney, MD Jon Wee, MD Anthony Prince, MD Tari King, MD Daniel Wiener, MD Herve Y. Sroussi, DMD, PhD Rachel E. Roditi, MD Sayeed Malek, MD Nathaniel S. Treister, DMD, DMSc Ravindra Uppaluri, MD, PhD Faina Nakhlis, MD Urology Sook-Bin Woo, DMD, MMSc Chandrajit Raut, MD Plastic Surgery Esther Rhei, MD Steven Chang, MD, MS Douglas Smink, MD, MPH Adam Kibel, MD Matthew Carty, MD Ali Tavakkoli, MD Michael Malone, MD Yoon Chun, MD Ashley Vernon, MD Michael O’Leary, MD, MPH Dennis Orgill, MD, PhD Graeme Steele, MD Andrea Pusic, MD 39

Development With our donor’s support, the Brigham Department of Surgery is able to deliver the highest quality patient care, pursue the most innovative and promising medical research and train the brightest medical minds to become the next generation of health care leaders. Bells’ $1 million gift ushers chair of the Brigham Board of Trustees. contingencies are examined. That, to in new ideas in lung and “Cross-fertilization of knowledge me, is their strength.” cancer care will make the award winners better clinicians and researchers, and help David and his wife, Diane, have For Lee and Mike Bell, the Brigham senior investigators become better expressed gratitude for this excellent means family. Lee was born at the mentors.” care through philanthropy, which has Brigham, then known as the Peter made a direct and immediate lifesaving Bent Brigham Hospital. Their children, “The Bells’ generosity is filling an Elaina and David, were also born at the important need—enabling young difference for countless patients. hospital—where David now works. investigators to pursue new ideas, grow For example, early in the COVID-19 their careers, and gain experience that pandemic, the Canepari family helped This feeling extends to their everyday leads to larger grants advancing their the hospital purchase additional encounters. “From doctors’ visits to work,” Dr. Bueno says. ECMO (extracorporeal membrane board meetings, everybody we’ve come oxygenation) machines, which were in touch with treats us like family,” Lee The Bells understand that behind the used in some serious COVID cases. says. “It’s the culture.” investigators’ scientific inquiry is the The equipment also plays an important desire to help patients. role in sustaining patients awaiting That’s why the Bells feel strongly lung transplants or needing respiratory about investing in people at the As the Lung Center worked out support in intensive care. Brigham. Over the years, they have details of the awards, Lee experienced supported women’s leadership in medical issues. “Dr. Bueno advocated Recently, the couple gifted the medicine, and now they are focusing for me and helped me get the best care hospital to establish the Canepari Family on early-career investigators. Lee, who quickly,” Lee says. “People like him exist Distinguished Chair in Thoracic Surgery. serves on the Cancer Research and everywhere in the hospital; they really The first recipient is Scott J. Swanson, Care Advisory Board, and Mike, who care.” MD, a respected surgeon and Lung chairs the Lung Center Advisory Board, Center leader known for his minimally committed $1 million to create the Bell “With our gift, we want to support invasive techniques and dedication to Family Research Accelerator for Lung, this kind, nurturing environment and training future thoracic surgeons. Pulmonary, and Cancer Research in energize brilliant people to get more The Lung Center, an endowed source of answers to improve lives,” says Mike. “This gift is yet another remarkable support for grant awards. The Bells also example of Diane and David’s contributed $50,000 to immediately Canepari family establishes steadfast commitment to the Lung offer two awards in winter 2022. distinguished chair in thoracic Center,” Dr. Bueno says. “I could not be surgery To deepen collaborations between pulmonary care and thoracic surgery, In 2016, David Canepari thought the Lung Center’s co- directors, Raphael he had lung cancer. His physicians in Bueno, MD, and Bruce Levy, MD, Rhode Island had run tests and scans structured the awards so each applicant and showed him the large growths in pairs with a senior researcher of a his lungs. A friend recommended that different discipline. he meet with Raphael Bueno, MD, chief of the Division of Thoracic and Cardiac “Bruce and Raphael are thinking how Surgery and co-director of the Lung to create better physicians to treat Center at the Brigham. Through careful, COPD, lung cancer, asthma and other multidisciplinary evaluation, Dr. Bueno complex cases,” says Mike, former and his team determined that David’s condition was noncancerous and treatable with antibiotics. “I have tremendous respect for Raphael and his entire team,” says David, who has since become a benefactor and volunteer of the Lung Center. “They treat the entire person, not just the patient, and use a holistic approach to ensure that all 40

prouder to see Scott honored with this J. Mentzer, MD; radiation oncologist unlock new treatment possibilities distinguished chair. He is instrumental Raymond H. Mak, MD; for patients. The couple recently in keeping our division at the forefront of and pulmonologist Christopher H. committed $100,000 to establish the pioneering research and treatment for Fanta, MD. Máde and Richard Berg Mesothelioma patients with complex lung diseases.” Research Fund at the Brigham. “My experience at the Brigham The Caneparis believe that supporting underscores the value of The Bergs’ gift extends their previous the distinguished chair is about creating multidisciplinary care across pulmonary support of the Brigham’s mesothelioma opportunities for the center’s talent and and thoracic services,” says George, research programs and reflects their ultimately saving lives. a member of the hospital’s Lung admiration for Richard’s surgeon, Center Advisory Board. “We wanted Raphael Bueno, MD, the chief of the “This feels like a real contribution to show our gratitude to these brilliant Division of Thoracic and Cardiac to a better way of life, of recovery, and physicians by advancing their priorities, Surgery and a renowned expert on this of battling these diseases, and that is whether they be clinical, scientific or aggressive form of lung cancer. personal to us,” David says. “We hope educational.” others will actively support the Lung “Dr. Bueno and his team are Center for the special place it is and The Dennys’ philanthropy will unmatched in their ability to change can become.” support the George P. Denny, MD, the future of this disease,” Richard International Research Fellowship says. “We want to do everything we can Dennys’ gift span generations Fund, directed by Dr. Mentzer. Their gift to help them discover new treatment of exceptional Brigham care also provides resources for Dr. Mak’s pathways and, ultimately, a cure.” radiation oncology research and Dr. George Denny has a unique Fanta’s pulmonary medicine initiatives, Mitchell Distinguished Chair in perspective of the Brigham’s past, including his work directing the Mass Thoracic Surgery recognizes present and future. A century ago, his General Brigham Asthma Center. extraordinary care grandfather and namesake, George P. Denny, MD, walked the halls of the Peter “Thanks to George and Leigh’s In the two decades since Jack Bent Brigham Hospital as a physician- generosity, we extended a fellowship Mitchell met his thoracic surgeon, Mike researcher. According to a 1961 tribute opportunity to Willi Wagner, MD, a Jaklitsch, MD, FACS, at the Brigham, in the Harvard Medical Alumni Bulletin, talented interventional radiologist they have profoundly impacted each the elder Denny cared for patients from the University of Heidelberg in other’s lives. ranging “from a cook in Roxbury to the Germany,” Dr. Mentzer says. “This is late J.P. Morgan. All were treated with a wonderful way to honor George’s Through a difficult diagnosis, to the the same kindly and careful, efficient grandfather’s legacy and foster good health he enjoys today, Mitchell interest that is the hallmark of the truly collaboration and knowledge exchange has drawn strength from the integrity great physician.” to enhance lung disease treatment and unwavering optimism Dr. Jaklitsch and care.” brings to his care. To pay forward the Generations later, the younger trust he feels as a patient, Mitchell has Denny has benefited from similarly Bergs further commitment to championed education, research and outstanding physicians at the Brigham, mesothelioma research patient care in the Division of Thoracic some practicing in the same building and Cardiac Surgery through his as his grandfather. Recently, George As someone who has benefited from philanthropy. and his wife, Leigh, committed a total advanced mesothelioma care at the of $300,000 to programs led by three of Brigham, Richard Berg, along with his Recently, Mitchell made a generous his doctors: Thoracic surgeon Steven wife, Madé, wants to help clinicians gift to help establish the John D. 41

Mitchell Distinguished Chair in Thoracic for patients. Since then, they have Support Surgery, with Dr. Jaklitsch named as the continued their support of the chair, first incumbent. most recently making an additional the Work $500,000 contribution. of the “This is a big commitment, and I Department want to do everything in my power to The Crowleys’ gift provides critical of Surgery help Dr. Jaklitsch share his talent, skill, resources to surgeon-in-chief, Gerard and strength of character with patients Doherty, MD, to bolster the hospital’s Each year, thousands of people and the medical community,” Mitchell surgical excellence while advancing entrust the Department of Surgery says. “For a person of his caliber, I feel scientific research and training the next at Brigham Health to provide them the best gift I could give is the flexibility generation of leaders in surgery. with excellent medical care. Many to hone his craft, pursue new research people turn to us because of our and inventions, and continue training The funding has helped several long history of medical firsts and doctors alongside him.” initiatives for the department, including reputation for attracting the finest expanding cancer care provided by surgical trainees and surgeons in In addition to bringing the faculty at the Brigham and across the the country. One of the reasons distinguished chair to fruition, Mitchell Mass General Brigham network and we have been able to build such a has served as a member of the increasing oncology-focused research strong program—and to establish Brigham’s Lung Center Advisory Board and training. In addition, the department new standards of surgical care— and funded fellowship opportunities, a opened a weight management and is because of philanthropic smoking cessation program and other wellness center that couples surgical contributions from people like you. patient education resources. He also and endoscopic procedures with assisted the hospital with purchasing counseling on diet, medicine and Gifts from our alumni, patients ECMO (extracorporeal membrane lifestyle modifications. and friends help us to train oxygenation) machines during the first our staff in the latest surgical wave of COVID-19 in 2020. “I’m so grateful to see these techniques, to make advances advancements take shape as the in surgery through research and “It’s hard to overstate the impact Jack Brigham builds on its legacy as a world- to achieve the best possible has made on the Brigham community,” class leader in surgery,” Andy says. outcomes for patients. When you Dr. Jaklitsch says. “He has generously “We’re honored to support Dr. Doherty make a gift to the Department given his time, passion, experience and in his pioneering research and as he of Surgery, you enable our resources to better the lives of others. nurtures outstanding young surgeons medical team to provide the I am honored to hold a distinguished who are shaping the future of the field.” most advanced care and make a chair bearing his name.” difference for every patient and Dr. Doherty is inspired by the family member we see. Mitchell expresses a sense of Crowleys’ ongoing generosity and assurance and hope for the future of partnership. “Andy and Janice’s support For more information if you medicine, knowing that more doctors of my leadership has been pivotal are interested in making a gift will learn to practice with expertise, in our efforts to continue providing to the Department of Surgery at compassion and positivity through Dr. outstanding care,” Dr. Doherty says. Brigham and Women’s Hospital, or Jaklitsch’s guidance. “Their philanthropy is an investment to a specific physician or scientist in our entire Brigham community, within the department, please “I live in gratitude of Mike Jaklitsch providing the flexibility to innovate, contact Susan Andrews, assistant and consider him my friend,” Mitchell educate, and ultimately, be of greater vice president of the Development says. “I’m humbled to be his patient, and service to our patients.” Office, at 617.424.4349 or thanks to his wonderful care, I can look [email protected] forward to many more years of health and friendship ahead.” Crowley family empowers stellar surgical leadership Andy and Janice Crowley are grateful for the excellent care their family has received at the Brigham for many years. In 2013, they established the Crowley Family Distinguished Chair in the Department of Surgery with an endowed gift to fuel pioneering improvements and innovations in surgical care 42

In Memoriam Robert T. Osteen, MD (1941-2022) The Department of Surgery mourns Colleagues remember Dr. Osteen not WWII based on over 300 letters written the loss of Robert Osteen, MD, a only as a great surgeon but also a great to his wife. Dr. Osteen collected his own cancer surgeon and educator whose teacher—one who inspired others both poetry, written over 50 odd years, in a contributions to the field of surgical personally and professionally with his book entitled, Zero to Five Knots and oncology influenced generations guidance and wisdom. In recognition a Book, which focused on his love of of surgeons. He died July 14 from of his lasting influence on surgical sailing, children, nature and his wife. complications following an injury. He education, the Department of Surgery was 81. established a Junior Faculty Fellowship Dr. Osteen is survived by his wife of Award in his honor in 2006. 58 years, Carolyn McCue Osteen; two With a remarkable tenure spanning daughters, Carolyn (Morey) Osteen almost 50 years at the Brigham, Dr. In retirement, Dr. Osteen delved into Ward and Sarah Lloyd Osteen; and four Osteen established himself as a leading his interests of history and poetry. A grandchildren. expert in surgery for tumors of the lover of maps and sailing, he collected pancreas, liver, stomach, esophagus, many antique maps. He wrote his first Dr. Osteen was born in Augusta, colon, breast and other organs. book in 2014, Festina Lente: Charting Georgia on February 14, 1941, and grew Throughout his career, he served as an the Mediterranean 1814-1824, about up in Savannah, Georgia. He graduated influential and beloved surgeon, teacher William Henry Smyth’s charting of from Dartmouth College and Duke and mentor. Gifted with a sharp mind, the Mediterranean. He dove into the University Medical School and served colleagues frequently consulted Dr. experience, even learning the 1850 in the U.S.A.F. from 1968 to 1970, Osteen for clinical guidance. Although method for measuring longitude primarily engaging in medical research he retired from clinical practice in 2006, between the moon and fixed star. In focused on transplant surgery. In 1974, he remained engaged in the instruction 2021, he finished his second book, he completed his surgical residency at and mentorship of students and Surgery Under Fire, outlining his father’s the Peter Bent Brigham Hospital, now trainees. experience as an anesthesiologist in Brigham and Women’s Hospital, where he spent his entire career. 43

Leadership Philip D. Roberts, MBA Executive Administrator Gerard M. Doherty, MD Moseley Professor of Surgery, Harvard Medical School Sarah Broughton Herd Surgeon-in-Chief, Brigham and Women’s Hospital & Director, Surgery Education Office Dana-Farber Cancer Institute Crowley Family Distinguished Chair, Department of Surgery, Suzanna Clark, MHA Brigham and Women’s Hospital Senior Director of Operations C. Keith Ozaki, MD Matthew S. Sandler, MBA Executive Vice Chair, Department of Surgery, Brigham and Senior Director of Finance Women’s Hospital John A. Mannick Professor of Surgery, Brigham and Women’s David A. Steger, MS Hospital Director of Communications and Faculty Affairs Professor of Surgery, Harvard Medical School Gina Tonogbanua Custer, MA, CRA Douglas S. Smink, MD, MPH Administrative Director of Research Chief of Surgery, Brigham and Women’s Faulkner Hospital Vice Chair for Education Victoria (Tori) Wilmarth, MBA Professor of Surgery, Harvard Medical School Director of Network Strategy Ronald Bleday, MD Division Administrators Vice Chair for Quality and Patient Safety Breast Surgery: Paul Buckley, MBA Tari A. King, MD Cardiac Surgery: Sara Zent, MBA Vice Chair for Multidisciplinary Oncology General and Gastrointestinal Surgery: Jennifer Fanning Oral Medicine: Nathan J. Burke, MBA Elizabeth Mittendorf, MD, PhD Otolaryngology—Head and Neck Surgery: Michelle Swoboda, MHA Vice Chair for Research Plastic and Reconstructive Surgery: Shannon Weiss, RN, MBA Surgical Oncology: Jenna Khalili, MBA Louis L. Nguyen, MD, MPH, MBA Thoracic Surgery: Philip Girard, MS Vice Chair for Digital Health Systems Transplant Surgery: Keila Jackson, MHA Trauma, Burn, Surgical and Critical Care: Susannah Rudel, MPH, MBA Malcolm K. Robinson, MD Urology: Sandra Doolan, MBA Vice Chair for Clinical Operations Vascular and Endovascular Surgery: Lorraine T. Levitsky Ali Salim, MD Vice Chair for Surgical Critical Care Jennifer Shin, MD, SM Vice Chair for Faculty Development Jennifer Beatty, PA-C Director of Clinical Operations and Surgical Physician Assistants Department of Surgery • 75 Francis Street • Tower 1 – Room 110 • Boston, MA 02115 Contact Us • [email protected] • 617.732.8181 Follow Us • twitter.com/brighamsurgery Brigham Surgery Alumni Stay in Touch! The Brigham Surgery Alumni Group consists of graduates of Brigham and Women’s Hospital surgery residency and fellowship programs and former Department of Surgery faculty members. If you would like to join the Brigham Surgery Alumni Group a4n4d receive news and updates from the Department of Surgery, please visit: brighamsurgerynews.com/alumni/ or email us at: [email protected]