Department of Surgery 2021 Annual Report

2021 Annual Report Department of Surgery 1

Department of Surgery by the numbers 11 187 26 clinical divisions faculty active clinical trials 5 12 5 ACGME-accredited non-ACGME-accredited ACGME-accredited surgical residency programs surgical fellowships surgical fellowships 28,088 192,251 operations performed 37 office visits 152 231 interns and residents fellows active grants $43,231,910 research spending 2

A Letter from the Chair Over the past year, the Department of Surgery has continued to build on our proud history of clinical and academic achievement. This year once again presented us with unique challenges as we navigated the COVID-19 pandemic and the continued complexities of providing care in this environment. I remain extremely proud of the varied ways that every member of the department has contributed to our mission to care for patients and support one another. This year we saw our faculty continue to grow as we welcomed a record 21 new faculty members. Raphael Bueno, MD, was named chief of our newly formed Division of Thoracic and Cardiac Surgery, and we also named three new endowed chairs: Zara Cooper, MD, MSc, as the Michele and Howard J. Kessler Distinguished Chair in Surgery and Public Health; Ali Salim, MD, as the BWH Distinguished Chair in Surgery; and Stefan G. Tullius, MD, PhD, as the Joseph E. Murray Distinguished Chair in Transplant Surgery. We had a number of exciting new clinical programs start this year. We opened our Center for Weight Management and Wellness, which strives to transform obesity medicine and is an excellent model of effective multidisciplinary clinical care. Also, our newly formed Mass General Brigham Liver Transplant Program was launched. This integrated and comprehensive program comprised of both Massachusetts General Hospital and Brigham and Women’s Hospital clinicians greatly expands options for patients with acute or chronic liver disease. Our department continues to be on the cutting edge of surgical research with new grant funding to study the role of palliative care in surgery for older seriously ill patients; to examine the multifaceted biology of PARP proteins and their evolving impact on cancer therapeutics for future development and clinical application, benefiting patients with incurable metastatic castrate-resistant prostate cancer; and to study and evaluate the CA7S metabolite as a novel therapy for type 2 diabetes. The Brigham also announced a new leader this year. We are very excited to welcome Robert S.D. Higgins, MD, MSHA, as our next Brigham and Women’s Hospital president and executive vice president at Mass General Brigham. Dr. Higgins joins the Brigham from Johns Hopkins, where he served as surgeon-in-chief at Johns Hopkins Hospital and as the William Stewart Halsted Professor of Surgery and the director of the Department of Surgery at Johns Hopkins University School of Medicine. Dr. Higgins is known to many of us in the department as an extraordinary leader. He has a deep understanding of the complexity of academic medicine and surgery, and we are lucky to have him join our organization. Our annual report highlights just some of the many examples of our ongoing commitment to excellence in clinical care, research and surgical education. Thank you for taking the time to read our report. We look forward to connecting with you again soon. Gerard M. Doherty, MD Moseley Professor of Surgery, Harvard Medical School Surgeon-in-Chief, Brigham and Women’s Hospital & Dana-Farber Cancer Institute Crowley Family Distinguished Chair, Department of Surgery, Brigham and Women’s Hospital 3

Faculty Department of Surgery The Brigham attracts internationally renowned surgeons who create pioneering breakthroughs that make a difference for patients today, as well as for generations to come. We are committed to delivering world-class, collaborative patient care with a profound human touch, while advancing scientific research and training the surgical innovators of tomorrow. Breast Surgery General and Gastrointestinal Surgery Metabolic and Bariatric Surgery Tari A. King, MD Chief, Division of Breast Surgery Ali Tavakkoli, MD Scott A. Shikora, MD Anne E. Dyson Professor of Surgery in the Chief, Division of General and Section Chief, Metabolic and Field of Women’s Cancers Gastrointestinal Surgery Bariatric Surgery Associate Professor of Surgery Professor of Surgery Thanh U. Barbie, MD Assistant Professor of Surgery Colon and Rectal Surgery Neil D. Ghushe, MD Instructor in Surgery Laura S. Dominici, MD Ronald Bleday, MD Assistant Professor of Surgery Section Chief, Colon and Rectal Surgery Malcolm K. Robinson, MD Associate Professor of Surgery Associate Professor of Surgery Olga Kantor, MD, MS Joel E. Goldberg, MD Member of the Faculty of Surgery Assistant Professor of Surgery Eric G. Sheu, MD, PhD Jennifer L. Irani, MD Assistant Professor of Surgery Alison Laws, MD Assistant Professor of Surgery Instructor in Surgery Nelya Melnitchouk, MD David Spector, MD Assistant Professor of Surgery Instructor in Surgery Christina A. Minami, MD, MFA, MS Melissa M. Murphy, MD, MPH Assistant Professor of Surgery Instructor in Surgery Thomas C. Tsai, MD, MPH James Yoo, MD Assistant Professor of Surgery Elizabeth Mittendorf, MD, PhD Associate Professor of Surgery Robert and Karen Hale Distinguished Ashley H. Vernon, MD Chair in Surgical Oncology Assistant Professor of Surgery Professor of Surgery Paul B. Davidson, PhD Faina Nakhlis, MD Instructor in Psychiatry Assistant Professor of Surgery Mark Gorman, PhD Suniti Nimbkar, MD Instructor in Psychology Assistant Professor of Surgery Esther Rhei, MD Assistant Professor of Surgery Anna Weiss, MD Assistant Professor of Surgery

Otolaryngology– Head and Neck Surgery Minimally invasive surgery Oral Medicine Ravindra Uppaluri, MD, PhD (MIS) and general surgeons Chief, Division of Otolaryngology—Head Nathaniel S. Treister, DMD, DMSc and Neck Surgery Stanley W. Ashley, MD Chief, Division of Oral Medicine BWH Distinguished Chair in Otolaryngology Frank Sawyer Professor of Surgery Associate Professor of Oral Medicine, Associate Professor of Otolaryngology Infection, and Immunity Head and Neck Surgery David C. Brooks, MD Associate Professor of Surgery Kentaro Ikeda, DDS, MPH, FDS RCSEd Donald J. Annino, MD, DMD Instructor in Oral Medicine, Infection, and Assistant Professor of Otolaryngology John J. Froio, MD Immunity Head and Neck Surgery Instructor in Surgery Herve Y. Sroussi, DMD, PhD Regan Bergmark, MD Pardon R. Kenney, MD, MMSc Assistant Professor of Oral Medicine, Instructor in Otolaryngology Head and Neck Senior Lecturer on Surgery Infection, and Immunity Surgery Erika L. Rangel, MD, MS Piamkamon Vacharotayangul, DDS, Thomas L. Carroll, MD Assistant Professor of Surgery PhD Assistant Professor of Otolaryngology Instructor in Oral Medicine, Infection, Head and Neck Surgery Andrew Resnick, MD and Immunity Member of the Faculty of Surgery Carleton E. Corrales, MD Sook-Bin Woo, DMD, MMSc Assistant Professor of Otolaryngology Brent T. Shoji, MD Associate Professor of Oral Medicine, Head and Neck Surgery Assistant Professor of Surgery Infection, and Immunity Christopher Dwyer, MD, FRCSC Douglas S. Smink, MD, MPH Instructor in Otolaryngology Head and Neck Associate Professor of Surgery Surgery Edward E. Whang, MD Laura A. Goguen, MD Associate Professor of Surgery Associate Professor of Otolaryngology Head and Neck Surgery Alice Z. Maxfield, MD Assistant Professor of Otolaryngology Head and Neck Surgery Anju K. Patel, MD Instructor in Otolaryngology Head and Neck Surgery Anthony A. Prince, MD Instructor in Otolaryngology Head and Neck Surgery Eleni Rettig, MD Instructor in Otolaryngology Head and Neck Surgery Rachel E. Roditi, MD Instructor in Otolaryngology Head and Neck Surgery Rosh Sethi, MD, MPH Assistant Professor of Otolaryngology Head and Neck Surgery Jennifer J. Shin, MD, SM Associate Professor of Otolaryngology Head and Neck Surgery 5

Plastic and Reconstructive Surgical Oncology Thoracic and Cardiac Surgery Surgery Chandrajit P. Raut, MD, MSc Raphael Bueno, MD Andrea Pusic, MD, MHS Chief, Division of Surgical Oncology Chief, Division of Thoracic and Chief, Division of Plastic and BWH Distinguished Chair in Surgical Cardiac Surgery Reconstructive Surgery Oncology Fredric G. Levin Distinguished Chair Joseph E. Murray Professor of Surgery in Thoracic Surgery and Lung Cancer Professor of Surgery Research Monica M. Bertagnolli, MD Professor of Surgery Shailesh Agarwal, MD Richard E. Wilson Professor of Surgery in Assistant Professor of Surgery the Field of Surgical Oncology Thoracic Surgery Justin Broyles, MD Thomas E. Clancy, MD Antonio Coppolino, III, MD, MSc Assistant Professor pf Surgery Distinguished Scholar in Surgical Oncology Instructor in Surgery Assistant Professor of Surgery Matthew J. Carty, MD Christopher T. Ducko, MD Associate Professor of Surgery Mark Fairweather, MD Assistant Professor of Surgery Assistant Professor of Surgery Benjamin P. Christian, MD Michael T. Jaklitsch, MD Instructor in Surgery George Molina, MD, MPH Professor of Surgery Assistant Professor of Surgery Yoon S. Chun, MD Hassan Khalil, MD Associate Professor of Surgery Jiping Wang, MD, PhD Member of the Faculty of Surgery Assistant Professor of Surgery Jessica Erdmann-Sager, MD Abraham Lebenthal, MD, MHA Assistant Professor of Surgery Charles H. Yoon, MD, PhD Assistant Professor of Surgery Assistant Professor of Surgery Lydia A. Helliwell, MD Hari R. Mallidi, MD Instructor in Surgery Endocrine Surgery Associate Professor of Surgery Dennis P. Orgill, MD, PhD Nancy L. Cho, MD M. Blair Marshall, MD, FACS Professor of Surgery Assistant Professor of Surgery Michael A. Bell Family Distinguished Chair in Healthcare Innovation Kavitha Ranganathan, MD Gerard M. Doherty, MD Associate Professor of Surgery Assistant Professor of Surgery Moseley Professor of Surgery Ciaran McNamee, MD, MSc Christian E. Sampson, MD Atul A. Gawande, MD, MPH Assistant Professor of Surgery Assistant Professor of Surgery Cynthia and John F. Fish Distinguished Chair in Surgery Steven J. Mentzer, MD Indranil Sinha, MD Samuel O. Thier Professor of Surgery Professor of Surgery Assistant Professor of Surgery Matthew A. Nehs, MD Namrata Patil, MD, MPH Simon G. Talbot, MD Assistant Professor of Surgery Assistant Professor of Surgery Associate Professor of Surgery 6

Transplant Surgery Trauma, Burn and Surgical Critical Care Matthew Pommerening, MD Member of the Faculty of Surgery Stefan G. Tullius, MD, PhD Ali Salim, MD Chief, Division of Transplant Surgery Chief, Division of Trauma, Burn Matthew M. Rochefort, MD Joseph E. Murray Distinguished Chair and Surgical Critical Care Instructor in Surgery in Transplant Surgery BWH Distinguished Chair in Surgery Professor of Surgery Professor of Surgery Scott J. Swanson, MD Professor of Surgery Sayeed K. Malek, MD Geoffrey Anderson, MD, MPH Assistant Professor of Surgery Member of the Faculty of Surgery Hisashi Tsukada, MD, PhD Assistant Professor of Surgery Reza Askari, MD Assistant Professor of Surgery Jon O. Wee, MD Assistant Professor of Surgery Gustavo J. Bauzá, MD Instructor in Surgery Brian Whang, MD Instructor in Surgery Christopher J. Burns, MD Instructor in Surgery Abby A. White, DO Assistant Professor of Surgery Cristina Carpio, MD Instructor in Surgery Daniel C. Wiener, MD Assistant Professor of Surgery Jason E. Cohen, DO John Young, MD Zara R. Cooper, MD, MSc Instructor in Surgery Michele and Howard J. Kessler Distinguished Chair in Surgery and Cardiac Surgery Public Health Associate Professor of Surgery Sary F. Aranki, MD Associate Professor of Surgery David W. Fink, MD Instructor in Surgery Tsuyoshi Kaneko, MD Assistant Professor of Surgery Joaquim M. Havens, MD Associate Professor of Surgery Anastasios Konstantakos, MD Anupama Mehta, MD Dan Loberman, MD Instructor in Surgery Instructor in Surgery Stephanie L. Nitzschke, MD, MS Daniel E. Rinewalt, MD Assistant Professor of Surgery Member of the Faculty of Surgery Nakul Raykar, MD, MPH Ashraf A. Sabe, MD Member of the Faculty of Surgery Member of the Faculty of Surgery Robert Riviello, MD, MPH Steven C. and Carmella R. Kletjian Foundation Distinguished Chair in Global Surgery Associate Professor of Surgery Naomi Shimizu, MD Instructor in Surgery 7

Urology Vascular and Endovascular Research Surgery Matthew Brian Couger, PhD Adam S. Kibel, MD Michael Belkin, MD Lead Investigator Chief, Division of Urology Chief, Division of Vascular Member of the Faculty of Surgery Elliott Carr Cutler Professor of Surgery and Endovascular Surgery Professor of Surgery Marie Billaud, PhD William Boysen, MD Lead Investigator Member of the Faculty of Surgery Garima Dosi, MD Zi Chen, PhD Elodi J. Dielubanza, MD Edwin C. Gravereaux, MD Lead Investigator Instructor in Surgery Instructor in Surgery Member of the Faculty of Surgery George Haleblian, MD Mohamad Hussain, MD, PhD, RPVI Assunta De Rienzo, PhD Assistant Professor of Surgery Member of the Faculty of Surgery Lead Investigator Assistant Professor of Surgery Martin Kathrins, MD Edward J. Marcaccio, Jr., MD Assistant Professor of Surgery Assistant Professor of Surgery Tanujit Dey, PhD Lead Investigator Arthur F. Little, MD Matthew T. Menard, MD Assistant Professor of Surgery Instructor in Surgery Associate Professor of Surgery Maria Edelen, PhD Michael J. Malone, MD Louis L. Nguyen, MD, MBA, MPH Lead Investigator Instructor in Surgery Associate Professor of Surgery Member of the Faculty of Surgery Michael W. McDonald, MD C. Keith Ozaki, MD Ann Marie Egloff, PhD, MPH Assistant Professor of Surgery John A. Mannick Professor of Surgery Lead Investigator Professor of Surgery Assistant Professor of Surgery Kathy Golbarg Niknejad, MD Member of the Faculty of Surgery Marcus E. Semel, MD, MPH Jennifer Guerriero, PhD Instructor in Surgery Lead Investigator Michael P. O’Leary, MD, MPH Assistant Professor of Surgery Professor of Surgery Molly Jarman, PhD, MPH Daniel A. Wollin, MD Lead Investigator Member of the Faculty of Surgery Assistant Professor of Surgery Urologic Oncology Li Jia, PhD Lead Investigator Assistant Professor of Surgery Steven L. Chang, MD, MS Section Chief, Urologic Oncology Assistant Professor of Surgery Matthew Mossanen, MD, MPH Assistant Professor of Surgery Mark A. Preston, MD, MPH Assistant Professor of Surgery Graeme S. Steele, MD Assistant Professor of Surgery Quoc-Dien Trinh, MD Associate Professor of Surgery 8

Raouf A. Khalil, MD, PhD Education Lead Investigator Associate Professor of Surgery Jamie Robertson, PhD, MPH Director of Innovation in Surgical Education James A. Lederer, PhD Instructor in Surgery Lead Investigator Associate Professor of Surgery Emeritus Farhad Rikhtegar Nezami, PhD Francis D. Moore Jr., MD Lead Investigator Francis D. Moore Professor of Surgery, Member of the Faculty of Surgery Emeritus Steven Piantadosi, MD, PhD Anthony D. Whittemore, MD Senior Investigator Professor of Surgery, Emeritus Professor in Residence of Surgery Michael J. Zinner, MD William G. Richards, PhD Moseley Professor of Surgery, Emeritus Lead Investigator Assistant Professor of Surgery Affiliated faculty Gilbert Welch, MD, MPH Senior Investigator South Shore Hospital Joel S. Weissman, PhD Frederick Millham, MD Senior Investigator Chair of Surgery, South Shore Hospital Professor of Surgery Veteran’s Affairs (VA) Boston Jeremy M. Wolfe, PhD Healthcare System Senior Investigator Professor of Ophthalmology General Surgery Feng Yao, PhD Kamal Itani, MD Lead Investigator Chief, Surgery, VA Boston Healthcare Associate Professor of Surgery System Jason S. Gold, MD Gentian Kristo, MD Ann Smith, MD, MPH Cardiac Surgery Miguel Haime, MD Jacquelyn A. Quin, MD Marco Zenati, MD Plastic Surgery Shahe Fereshetian, MD Urology B. Price Kerfoot, MD Juan Garisto, MD Vascular Surgery Michelle C. Martin, MD Joseph Raffetto, MD Research Vivian Cristofaro, PhD Aldebaran Hofer, MD, PhD Maryrose P. Sullivan, PhD 9

New Division Chief having been licensed by industry. New Faculty Dr. Bueno has also invented and Raphael Bueno, MD continues to develop several novel Geoffrey Anderson, MD, MPH Chief, Division of Thoracic surgical procedures and devices. Trauma, Burn and Surgical Critical Care and Cardiac Surgery Co-Director, Lung Center Dr. Bueno is a member of numerous Dr. Anderson graduated from Duke prestigious national and international University with a BS in biology and Dr. Bueno is chief of Thoracic and professional societies. He has been an religion. He obtained an MPH at the Cardiac Surgery at Brigham and invited lecturer at teaching hospitals Harvard T.H. Chan School of Public Women’s Hospital, the Fredric Levin and universities around the country Health and his medical degree from the Distinguished Chair in Thoracic and internationally. At the Brigham, he Emory University School of Medicine. Surgery and Lung Cancer Research has built the largest division of thoracic He completed a general surgery and professor of surgery at Harvard surgery in the U.S., with 20 faculty residency at Massachusetts General Medical School. He completed his members and five affiliated network Hospital and a trauma and critical care bachelor’s degree at Harvard College sites in New England and co-founded fellowship at the University of Southern and medical training at Harvard the Brigham Lung Center and the Lung California Medical Center. Medical School/Massachusetts Research Center. Institute of Technology. He Dr. Anderson is board certified in subsequently trained in general surgery New Leadership general surgery and surgical critical at the Brigham and thoracic surgery at care. He is a member of various Massachusetts General Hospital and Anupama Mehta, MD professional societies, including the joined the Brigham thoracic faculty Medical Director, Brigham Burn Center American College of Surgeons (ACS), in 1996. Over the past 21 years, Dr. the Excelsior Surgical Society and the Bueno has developed robust clinical Dr. Mehta graduated with honors American Association for the Surgery and research portfolios at the Brigham. from Rutgers College and obtained her of Trauma (AAST). He has also mentored many fellows medical degree from the University and staff and previously served as the of Vermont. She completed a general He previously served in the Air Force cardiothoracic residency director surgery residency at Loyola University as a flight surgeon and was deployed at the Brigham. Medical Center and a burns and critical to Iraq and Afghanistan, where his care fellowship at the University of main role was to evacuate casualties His clinical focus is management Southern California, Los Angeles. Dr. from the battlefield on rotary and fixed of thoracic malignancies, particularly Mehta is board certified in general wing aircraft. He also assisted in the mesothelioma, lung cancer and surgery and surgical critical care. She ER and OR during numerous mass esophageal cancer. His main research is also a member of the American Burn casualty events and assisted with the interests center on the molecular Association (ABA) and the American H1N1 outbreak in Afghanistan. events that lead to malignancy in College of Surgeons (ACS). mesothelioma and lung cancer. Dr. Anderson’s clinical and research Specifically, Dr. Bueno focuses on Dr. Mehta’s clinical interests include interests include global surgery, the developing biomarkers for diagnosis, burn surgery and reconstruction, social determinants of traumatic prognosis and predicting therapy in wound healing, scar tissue diseases, implementation science and malignant pleural mesothelioma and management and burn critical care. surgical education. lung cancer. His research also includes She also treats pediatric burns and tumor sequencing and identification patients with Stevens-Johnson Marie Billaud, PhD of targetable pathways. He runs a syndrome (SJS) and toxic epidermal Thoracic and Cardiac Surgery molecular biology lab at the George necrolysis (TEN). Additionally, she has W. Thorn Medical Research Building interests in faculty development and Dr. Billaud is a graduate of the and has been funded for almost resident wellness initiatives. University of Bordeaux in France, two decades by the National Cancer where she obtained a PhD in health Institute, Department of Defense, Dr. Mehta succeeds Stephanie and life sciences, specializing in cell and various foundations and industry Nitzschke, MD, MS, who has served biology and physiology. She conducted grants. He has invented, patented as medical director of the Burn Center and licensed several algorithms and since 2017. medical devices for patient care, some 10

her postgraduate research at the reconstruction, GU trauma, gender Maria Edelen, PhD Cardiovascular Research Center at affirmation surgery and prosthetic Patient-Reported Outcomes, Value & the University of Virginia and the urology. He is particularly interested Experience (PROVE) Center Department of Cardiothoracic Surgery in the care of cancer survivors and at the University of Pittsburgh. Before managing the long-term side effects of Before coming to the Brigham, Dr. coming to the Brigham, Dr. Billaud was their life saving treatments. Edelen worked as a senior behavioral a research assistant professor in the scientist at the RAND Corporation, departments of Cardiothoracic Surgery Christopher Dwyer, MD, FRCSC where her research focused on patient- and Bioengineering at the University Otolaryngology—Head and Neck reported outcome (PRO) development, of Pittsburgh. Surgery refinement and evaluation in health settings. Dr. Edelen’s recent work has Her research focuses on vascular Dr. Dwyer received his medical focused on the use of PROs for quality physiology, with a special interest in degree from the Memorial University measurement in a number of contexts, cell-to-cell communication, reactive of Newfoundland in Canada. He including primary, specialty, post-acute oxygen species, nitric oxide signaling, also completed his BSc degree at and hospice care. endothelial function and smooth Memorial University, majoring in muscle cell excitation-contraction both chemistry and biochemistry. He At the PROVE Center, Dr. Edelen coupling. She applies her vast thereafter completed his residency will be directly involved in all activities expertise in smooth muscle biology training in otolaryngology-head and related to the center to acquire PROs and physiology to better understand neck surgery at Western University’s for selected surgery patients at the molecular and cellular alterations Schulich School of Dentistry and Brigham Health and to implement that lead to ascending aortic Medicine in Ontario, Canada. He then a culture that embeds PROs as a aneurysms. pursued subspecialty fellowship standard. She will lead efforts to training in laryngology and care of expand the center as a resource Dr. Billaud’s work has been the professional voice at UC San for faculty members in all surgical published as original research articles, Francisco. He is a fellow of the Royal disciplines, establish collaborations review articles and cover art in College of Physicians and Surgeons inside and outside of Brigham Health journals such as Circulation Research; of Canada. and Mass General Brigham, and Arteriosclerosis, Thrombosis and advance PRO reporting for outcomes Vascular Biology; Science Signaling; Dr. Dwyer specializes in the research, clinical care, quality and the Journal of Thoracic and medical and surgical care of voice, improvement and value-based Cardiovascular Research. airway and swallowing pathologies. health care. He is a strong advocate for offering William Boysen, MD a multidisciplinary, collaborative Dr. Edelen graduated from Boston Urology approach to patient care, aiming to College with a BA in psychology. She optimize outcomes and likelihood holds a master’s degree and a PhD in Dr. Boysen graduated from Amherst of sustainable, long-term success. quantitative psychology from the L.L. College and obtained his medical His research interests include Thurstone Psychometric Laboratory degree from Columbia University management and prevention of airway at the University of North Carolina, Vagelos College of Physicians and stenosis, balancing functional and Chapel Hill. Surgeons. He completed a urology oncologic outcomes of early glottic residency at the University of Chicago carcinoma, and pursuing future Jennifer Guerriero, PhD Medical Center and a fellowship in endeavors in treatment of chronic Breast Surgery complex genitourinary reconstruction cough. He is passionate about medical and cancer survivorship at Duke and surgical education, with a special Dr. Guerriero graduated from University Medical Center. interest in teaching residents and Northeastern University with a BS in medical students. Working alongside biochemistry. She obtained a PhD He is board eligible in urology and medical trainees has been a significant in immunology and pathology and a member of the American Urological factor for his decision to pursue a Association and the Society of career in academic medicine. Genitourinary Reconstructive Surgeons. Dr. Boysen’s clinical and research interests include all aspects of reconstructive urology: urethral 11

molecular and cellular biology at Stony fellowship at the Brigham. Surgery of the Royal College of Brook University. She completed a Dr. Hussain has over 50 manuscript Surgeons of Edinburgh. postdoctoral fellowship in medical oncology at DDCI. publications in journals such as Before coming to the Brigham, Dr. Circulation, Journal of the American Ikeda was an assistant professor of Dr. Guerriero is an instructor of College of Cardiology, and JAMA diagnostic and biological sciences/oral medicine at Harvard Medical School. Surgery and over 70 research medicine and family medicine at the She is a member of the American presentations/published abstracts. He University of Colorado School of Dental Association for Cancer Research has received several research grants/ Medicine. At the Brigham, he will also (AACR); the Society for Immunotherapy awards from institutions such as the serve as clinical director of the Division of Cancer (SITC), and the American Canadian Institutes of Health Research of Oral Medicine. In this role, he will Society of Clinical Oncology (ASCO). (CIHR) and the European Society for lead clinical improvement projects, She is a working group member of Cardiology (ESC). He is also a dedicated advise regarding opportunities to the Immuno-Oncology interest group teacher committed to the learning of promote clinical service, work with and the TNBC breast group of the trainees. He has taught ATLS to over clinic managers to ensure adequate Translational Breast Cancer Research 400 physicians in 30 courses and was scheduling, develop clinic policies and Consortium (TBCRC), which conducts honored with an ATLS teaching award. practice guidelines, coordinate division innovative and high-impact clinical trials clinical rounds and monitor faculty and for breast cancer. Dr. Hussain’s research interests staff compliance. include the study of vascular diseases Dr. Guerriero is also the director using observational epidemiology, Dr. Ikeda’s clinical and research of the breast immunology laboratory health services research, prospective interests include diagnosis and for the Dana-Farber Susan F. Smith clinical trials and knowledge management of oral mucosal diseases, Women’s Cancer Program, and she translation. He also has a special orofacial pain and oral complications serves on the Executive Committee of clinical interest in thoracic outlet of systemic diseases and their the Harvard Program in Therapeutic syndrome surgery. management/treatment. Science (HiTS). Kentaro Ikeda, DDS, MPH, FDS RCSEd Olga Kantor, MD, MS Dr. Guerriero’s research interests Oral Medicine Breast Surgery include harnessing the anti-tumor potential of tumor-associated Dr. Ikeda received a Doctor of Dental Dr. Kantor graduated from Rice macrophages for breast cancer Surgery from the Tokyo Dental College University with a BS in biochemistry immunotherapy, understanding how in Japan. He completed an infectious and cell biology. She obtained an MS breast cancer cell intrinsic mutations diseases fellowship at the University of in public health sciences from the regulate the tumor microenvironment, Medicine and Dentistry of New Jersey, University of Chicago and her medical and elucidating the biology, diversity followed by a special needs pediatric degree from the University of Illinois and ontogeny of tumor macrophages in dentistry residency at the Kanagawa at Chicago. She completed a general breast tumors. Children’s Medical Center in Yokohama, surgery residency at the University of Japan. Dr. Ikeda then completed a Chicago, a surgical oncology research Mohamad Hussain, MD, PhD, RPVI general practice residency and an oral fellowship at the NorthShore University Vascular and Endovascular Surgery medicine residency at the Carolinas HealthSystem and a breast surgical Medical Center. He also holds an oncology fellowship at Massachusetts Dr. Hussain graduated from the MPH from the University of North General Hospital, Brigham and University of Western Ontario with a Carolina at Chapel Hill School of Global Women’s Hospital and Dana-Farber BSc in medical sciences. He obtained Public Health. Cancer Institute. his medical degree from the Michael G. DeGroote School of Medicine at Dr. Ikeda is a member of various She is board certified in general McMaster University. He completed a professional organizations, including surgery. She is a member of various vascular surgery residency and a PhD the American Academy of Oral professional societies, including the in clinical epidemiology and health Medicine, the American Academy of American College of Surgeons (ACS), services research through the Surgeon Pediatric Dentistry and the American the Society of Surgical Oncology (SSO) Scientist Training Program at the Dental Association. He is a diplomat of and the American Society of Breast University of Toronto. Dr. Hussain also the American Board of Oral Medicine Surgeons (ASBrS). completed a cardiovascular research and a fellow of the Faculty of Dental Dr. Kantor’s clinical and research 12

interests include clinical trials, surgical advanced adult cardiac surgery at the George Molina, MD, MPH management after neoadjuvant therapy Brigham. Surgical Oncology and tailoring treatments in patients with breast cancer. She also has a special He is board certified in general and Dr. Molina graduated from Johns interest in surgical education and thoracic surgery, and he is a member Hopkins University with a BS in cellular will be taking on the role of associate of the American College of Surgeons and molecular biology. He obtained his program director for the breast surgical (ACS). Before returning to the Brigham, medical degree from Harvard Medical oncology fellowship. he worked for the MercyHealth Hospital School, and he completed an MPH System as a cardiothoracic surgeon. in quantitative methods at Harvard Hassan Khalil, MD T.H. Chan School of Public Health. Thoracic and Cardiac Surgery Dr. Konstantakos’ clinical and He completed his general surgery research interests include minimally residency at Massachusetts General Dr. Khalil graduated from the invasive valve surgery, complex Hospital (MGH) and a fellowship in University of Houston and obtained mitral valve repair, complex coronary complex general surgical oncology his medical degree from the University revascularization, aortic surgery, at the Brigham/MGH/Dana-Farber of Texas, Houston. He completed a reoperative cardiac surgery, cardiac Cancer Institute. general surgery residency at UCLA oncology, surgery for cardiac and two fellowships at the Brigham, arrhythmias, and patient outcomes As part of his general surgery one in minimally invasive thoracic and satisfaction. training, Dr. Molina also completed and foregut surgery and another in a two-year postgraduate research cardiothoracic surgery. Alison Laws, MD fellowship at Ariadne Labs, where he Breast Surgery worked on projects in health systems He is board certified in general innovation and research, global surgery surgery, and he is a member of various Dr. Laws graduated from the modeling, clinical studies in surgical organizations, including the Society of University of British Columbia and oncology, surgical safety culture in Thoracic Surgeons (STS), the American obtained her medical degree from inpatient and ambulatory settings College of Surgeons (ACS) and the McMaster University. She completed and impact of a surgical safety American Heart Association (AHA). a general surgery residency at the checklist program. University of Calgary and a breast Dr. Khalil’s clinical interests include surgical oncology fellowship at He is board certified in general lung cancer, mesothelioma, esophageal Massachusetts General Hospital/ surgery, and he is a member of the disease and robotic surgery. His Brigham and Women’s Hospital. American College of Surgeons (ACS), research will focus on mesothelium the American Society of Clinical and application of biomaterials in She is currently pursuing a Master Oncology (ASCO) and the Society of thoracic surgery. of Public Health in epidemiology from Surgical Oncology (SSO). the Harvard T.H. Chan School of Public Anastasios Konstantakos, MD Health. She is a member of the Society Dr. Molina’s clinical and research Thoracic and Cardiac Surgery of Surgical Oncology (SSO) and the interests include improving the safety, American Society of Breast Surgeons. quality and equity of surgical care Dr. Konstantakos graduated from through health systems innovation. He the University of Miami, where he Dr. Laws’ clinical and research is also interested in understanding the also obtained his medical degree. interests include optimizing oncologic impact of fragmentation of cancer care He completed a general surgery outcomes after breast cancer surgery, on disparities in surgical outcomes in residency at the Case Western improving cancer care delivery through the United States. Dr. Molina will be Reserve University, a fellowship in implementation of evidence-based conducting his research at the Center cardiothoracic surgery at Beth Israel practices, as well as managing patients for Surgery and Public Health and at Deaconess Medical Center, and at high-risk for breast cancer. Ariadne Labs. a fellowship and staff position in 13

Farhad Rikhtegar Nezami, PhD Kathy Golbarg Niknejad, MD by a thoracic surgery fellowship at Thoracic and Cardiac Surgery Urology the Brigham. He is board certified in general surgery, and he is a member Dr. Nezami graduated from the Dr. Niknejad graduated from San of the American College of Surgeons Amirkabir University of Technology in Diego State University with a BS in (ACS) and the Association for Tehran, Iran with a BSc in aerospace biology. She received her medical Academic Surgery (AAS). engineering, for which he also obtained degree from Harvard Medical School an MSc from the Sharif University of and completed the Harvard Urologic In residency, Dr. Pommerening Technology in Tehran. He holds a PhD Surgery Residency Program at the developed an interest in studying in mechanical engineering from ETH Brigham, where she was also a staff clinical outcomes and completed a Zurich in Switzerland. surgeon for five years. two-year clinical research fellowship and a master’s degree in clinical Before coming to the Brigham, Dr. Before returning to the Brigham, Dr. research established by the Center for Nezami worked at the Harvard-MIT Niknejad worked at Atrius Health as Clinical Research & Evidence-Based Biomedical Engineering Center as a the chief of Urology and was a member Medicine at McGovern Medical School. research scientist and project leader. of the board of trustees. She also At the Brigham, he will leverage worked at Harvard Vanguard Medical His clinical interests include the his expertise in bioinformatics, Associates, where she was the medical breadth of general thoracic surgery, computational modeling and vascular director of Surgical Specialties for including minimally invasive diagnostic biology from a pathophysiologic four years. and interventional procedures, lung perspective to achieve clinical impact cancer and advanced foregut surgery. by using multifaceted systems with Dr. Niknejad is board certified His research interests are focused on complex biological and mechanical in urology. She is a member of the designing and conducting clinical trials interactions. Dr. Nezami’s primary American Urological Association (AUA) to advance evidence-based practice in focus is on using computational and the Society of Women in Urology. thoracic surgery. methods to develop tractable and provably reliable test systems Dr. Niknejad’s clinical and research Kavitha Ranganathan, MD and novel data-driven design and interests include kidney stones, benign Plastic and Reconstructive Surgery optimization platforms to provide prostatic hypertrophy, bladder cancer, mechanistic understanding of prostate cancer, elevated PSA and Dr. Ranganathan is a plastic pathologies; asses the efficacy and active surveillance of prostate cancer, and reconstructive surgeon who optimize medical devices; and deliver urinary incontinence, hematuria, specializes in general reconstructive predictive means, diagnostic tools and recurrent urinary tract infections and and craniofacial surgery. She surgical guidelines to clinicians. overactive bladder. graduated from Northwestern University, where she also obtained Dr. Nezami’s research interests thus Matthew Pommerening, MD her medical degree at the Feinberg include computational pathophysiology Thoracic and Cardiac Surgery School of Medicine. She completed her (biofluid dynamics, biomechanics, residency at the University of Michigan. mathematical modeling); machine Dr. Pommerening is a graduate During her training, she also completed learning to analyze clinical data, of the University of Texas at Austin. a two-year research fellowship funded diagnostics/prognostics and clinical He received both his medical degree by the National Institutes of Health decision making; deep learning for and general surgery training from (NIH). She subsequently completed her medical image processing (fusion of the University of Texas McGovern fellowship in craniofacial surgery at modalities, plaque characterization, Medical School in Houston, where Johns Hopkins Medicine. etc.); data-driven design/optimization he also spent time studying clinical of medical devices and interventions; outcomes after traumatic injury. He Dr. Ranganathan’s clinical interests virtual surgery using Al and in silico went on to complete a cardiothoracic include craniofacial reconstruction, predictive/prognostic tools; as well surgery residency at the University of facial trauma care, secondary burn as drug delivery, solute transport, Pittsburgh Medical Center followed reconstruction, gender surgery and pharmacokinetics and optimization. general plastic surgery. Her research focuses on increasing access to care in resource-limited environments and addressing the burden of catastrophic expenditures in low- and middle- 14

income countries. At the Brigham, in head and neck oncology and research interests include improving Dr. Ranganathan will also be assuming microvascular reconstructive surgery the oral and general health in people the role of director of Craniofacial in the Department of Otolaryngology at living with HIV, as well as those Reconstruction. the University of Michigan. with chronic oral lesions and oral morbidities after head and neck Nakul Raykar, MD, MPH He is a member of the American cancer treatments. Trauma, Burn and Surgical Critical Care Head and Neck Society (AHNS) and the American Academy of Otolaryngology- John Young, MD Dr. Raykar graduated from Rutgers Head and Neck Surgery (AAO-HNS). Thoracic and Cardiac Surgery University with a BS in ceramic and materials engineering. He received Dr. Sethi’s clinical interests include Dr. Young graduated from Harvard his medical degree from Rutgers-New head and neck oncology and advanced University and obtained his medical Jersey Medical School and an MPH microvascular head and neck surgery, degree from Robert Wood Johnson from the Harvard T.H. Chan School with a strong emphasis on patient- Medical School. He completed a of Public Health. He completed his centered and multidisciplinary care general surgery residency at the general surgery residency at Beth of complex head and neck pathology. Warren Alpert Medical School of Brown Israel Deaconess Medical Center and a His research interests include health University and a cardiovascular and Paul Farmer Global Surgery Fellowship services research in otolaryngology. thoracic surgery fellowship at the from the Program in Global Surgery This broadly includes health market Zucker School of Medicine at Hofstra/ and Social Change at Harvard Medical research and adoption of medical Northwell. He most recently completed School. Most recently, he completed technology in otolaryngology, health a minimally invasive thoracic surgery a trauma/critical care medicine, outcomes around oncologic care, and fellowship at the Brigham. acute care surgery and global health cost-reduction measures for patients surgery fellowship at the University undergoing treatment for head and He is board certified in general of Pittsburgh Medical Center. He is neck cancer. surgery. In 2007, Dr. Young was board certified in general surgery and an American Gastroenterological surgical critical care. Piamkamon Vacharotayangul, Association student research fellow DDS, PhD at the Brigham in the lab of Stanley W. Dr. Raykar’s research interests Oral Medicine Ashley, MD, and Ali Tavakkoli, MD. include access safe blood transfusion, trauma systems development and Dr. Vacharotayangul received Dr. Young’s research interests surgical systems strengthening in low- her DDS from Mahidol University include immunology, lung trans- resource settings. and a graduate diploma in clinical plantation and thoracic oncology. sciences from Chulalongkorn His clinical areas of interest include Rosh Sethi, MD, MPH University in Bangkok, Thailand. She all aspects of adult general thoracic Otolaryngology—Head and Neck Surgery then completed a fellowship in oral surgery, end-stage lung disease, medicine at UC San Francisco, where lung transplantation, extracorporeal Dr. Sethi graduated from Yale she also completed a PhD in oral and membrane oxygenation (ECMO), College with a BS in biology. He craniofacial sciences. as well as utilization of the robotic obtained his medical degree from surgical platform. Harvard Medical School and an MPH She is board certified by the focused in quantitative methods from American Board of Oral Medicine. the Harvard T.H. Chan School of Public She is a member of the American Health. He completed a residency in Academy of Oral Medicine (AAOM), the otolaryngology-head and neck surgery Massachusetts Dental Society (MDS) at Massachusetts Eye and Ear/Harvard and the American Dental Association Medical School and a fellowship (ADA). Before coming to the Brigham, Dr. Vacharotayangul worked as head of the Division of Oral Medicine and instructor at Srinakharinwirot University. She was also a part-time oral medicine specialist in various private hospitals in Thailand. Dr. Vacharotayangul’s clinical and 15

New Center for Weight Management and Wellness Strives to Transform Obesity Medicine When Ali Tavakkoli, MD, a bariatric The Brigham has offered a variety offers endoscopic options designed for surgeon at the Brigham, describes the of weight management services for people who meet the qualifications for impact that weight loss treatment can many years, but they were scattered bariatric surgery but are not quite ready have for a patient, he doesn’t talk about across departments throughout the to undergo operations. percentages, body mass index (BMI) or hospital, making it difficult for patients numbers on a scale. Instead, he talks to understand their weight-loss options. Beyond procedures, patients can also about his patients’ day-to-day lives. In The CWMW brings all of these services seek medication, lifestyle coaching and a recent interview, Dr. Tavakkoli smiled under one umbrella, providing patients counseling services. The center offers as he fondly recalled a patient who had with easy access to experts across the group programs for patients to discuss undergone a weight loss procedure spectrum of obesity medicine. their weight loss journeys together, telling him how excited she was to have dieticians to help patients develop gone to a movie theater for the first “I truly believe the center will be the healthy eating habits and educational time in her life with her grandchildren — model for the rest of the academic services to teach patients about meal something she had been too afraid to do centers in the country,” Caroline planning and nutrition. Additionally, before losing weight. Apovian, MD, a leading expert in obesity on-site physical therapists help patients medicine and one of the center’s recover post-surgery and develop new “Obesity is a disease that has dramatic founding co-directors, said. “We are the exercise routines. impacts on patients’ health and quality first center in the country that combines of life,” Dr. Tavakkoli, chief of the Division all three modalities for obesity care in Patients typically sign up for an of General and Gastrointestinal Surgery, one place: Medical weight management, appointment online after their physician said. “Weight loss treatment can surgery and gastrointestinal (GI) refers them to the center. Once they transform people’s health and well-being procedures.” come in, medical professionals and open doors to new opportunities assess their needs and point them to their weight previously restricted them Focusing on what’s experts who can help them across all from pursuing.” best for the patient three disciplines. The clinicians then collaborate to meet each patient’s Dr. Tavakkoli, his co-directors and The center’s mission is to provide unique needs. their staff at the Center for Weight holistic and seamless care for all Management and Wellness (CWMW) patients. Clinicians at the center “I think this center is really unique aim to transform the way weight-related recognize that every patient comes with when you look regionally or nationally diseases, like obesity, are treated across a different story. Having a diverse array because it focuses on an unbiased the nation. The newly launched center at of services available enables clinicians assessment of people when they come the Brigham allows patients to access to provide every patient with the unique in and offers multiple ways to help the vast array of weight management combination of support they need. them,” Dr.Tavakkoli, who specializes services the hospital has to offer in one in minimally invasive gastrointestinal place. In addition to surgical procedures The center offers a wide range of procedures, said. He is an expert in like the ones Dr. Tavakkoli performs, surgical procedures such as gastric metabolic surgery and studies how the CWMW offers services such as bypass surgery, sleeve gastrectomy to improve surgical outcomes to not endoscopic procedures and counseling and revisional surgery performed both only help patients lose weight but focused on diet, medicine and lifestyle laparoscopically and robotically. It also also improve diabetes outcomes and modifications. increase overall health and well-being. 16

Reducing risks, education.” Expanding access improving outcomes Anyone seeking to lose weight can In the future, the center hopes Physicians recommend that patients visit the CWMW. While physicians to broaden access to services do not wait to get help with weight loss. typically do not recommend patients geographically, expand virtual care, Losing weight can help protect against with a BMI under 25 for surgery or recruit more clinicians and grow the and treat conditions such as diabetes medication, any patient, regardless research component of the center. and heart disease. Notably, it can also of their BMI, can come in for lifestyle help protect patients from some of the advice and counseling. “We have a very robust research severe risks associated with COVID-19. program looking at bariatric and According to the Centers for Disease “The center puts the patient first. We medical treatment outcomes. We are Control, having obesity may triple a do what’s best for them in the most finding that there is heterogeneity in person’s risk of hospitalization due to efficient way possible. The people that weight loss outcomes following our COVID-19. As body mass index (BMI) work here are incredibly accomplished procedures and medication. We’re increases, so does risk of death from and have deep expertise. Each discipline trying to get to the underpinning of COVID-19. has several experienced leading those differences. Why do some people physicians and researchers in the field,” lose a lot of weight after bariatric “Most patients wish that they had not Christopher Thompson, MD, director surgery and some people don’t? This is waited so long to get help with obesity,” of Endoscopy, and a co-director of the what we’re currently investigating,” Dr. Apovian said. “A lot of that has to CWMW, said. Dr. Thompson specializes Dr. Apovian said. do with stigma surrounding obesity, in gastrointestinal endoscopic and stigma can only be removed with techniques and has pioneered many of Dr. Thompson emphasized that a the endoscopic procedures existing in primary goal of the CWMW is to make the field today. weight loss treatment more accessible. 17

Mass General Brigham Liver Transplant Program Launches Collaborative approach expands options for patients with acute or chronic liver disease Leigh Anne Anna referring providers across institutions institution. Leigh Anne Dageforde, MD, Dageforde, Rutherford, and outreach clinics. Additionally, the MPH, an MGH transplant surgeon, and MD, PhD MD, PhD Mass General Brigham Liver Transplant Anna Rutherford, MD, MPH, clinical Program provides patients access director of Hepatology at the Brigham, In March 2021, Mass General to existing partnerships with Mass serve as surgical and clinical directors Brigham announced the launch of General Brigham clinical experts on of the Brigham clinic. the Mass General Brigham Liver both campuses, such as pediatric Transplant Program—an integrated and liver transplantation, oncology care “The synergy gained by joining forces comprehensive program comprised of through Dana-Farber Cancer Institute fosters liver transplant waiting list both Massachusetts General Hospital and the MGH Cancer Center, congenital growth by developing parallel and joint (MGH) and Brigham and Women’s heart disease related liver condition referral lines and outreach efforts at Hospital clinicians. The Brigham and treatment, a substance use disorder affiliated locations. This program also MGH have a rich history in performing clinic and a weight center. promotes growth through improved and developing organ transplant interaction and effective communication procedures. In 1954, the world’s first “This new program is an outstanding with referring providers pre- and post- successful organ transplant was example of ‘systemness’ in action. transplantation, allowing Mass General performed at the Brigham, and for over Before the launch, we needed to refer Brigham to be the dominant clinical liver 30 years, MGH has been a leader in liver patients at the Brigham who needed transplant program in the region,” Dr. transplantation, performing more than a liver transplant to other institutions. Dageforde said. 1,000 liver transplants to date. But by combining the resources of our world-class clinicians and staff, we’re Through the formation of this This collaboration expands able to deliver improved access to care partnership and program, Mass General care options to patients, providing and a more streamlined experience Brigham hopes to expand the approach complete treatment, transplant and for our patients,” Gerard Doherty, MD, to the evaluation of the patient’s liver management options for patients with surgeon-in-chief at the Brigham, said. condition, as well as provide and acute or chronic liver disease, as well increase access to liver disease care as patients with liver cancer. Patients In support of the new Liver Transplant and innovative therapies across the benefit from the extensive knowledge Program, a multidisciplinary clinic Mass General Brigham system and of the transplant experts from two opened in early 2021 at the Brigham. New England. of the highest-rated hospitals in New Patients now receive care through all England, as well as a standardized and the clinical phases of transplantation, “Both Dr. Dageforde and I are very comprehensive experience, including all including evaluation, transplant-specific excited about this new combined testing, waitlist and post-transplant transplant program. The combining care, by both institutions. Surgical care of the program allows us all to draw is exclusively performed at MGH, but from the amazing clinical and surgical once a patient begins care at either expertise at the Brigham, MGH and hospital, their ongoing liver disease Dana-Farber, and this in turn allows us to management continues at that same take the best care of our hepatology and transplant patients,” Dr. Rutherford said. 18

Education Current Residents Minh-Thuy Nguyen, MD Boston University School of Medicine The Department of Surgery combines General Surgery top-notch clinical care with world- Solomon Seckler, MD class research and cutting-edge Program Director: Icahn School of Medicine at Mount Sinai education to provide comprehensive Stephanie Nitzschke, MD, MS surgical training programs. Teaching Associate Program Directors: John Wieser, MD tomorrow’s leaders today… Mark Fairweather, MD; Jennifer Irani, MD; University of Virginia School of Medicine Matthew Nehs, MD; and Naomi Shimizu, fellows MD PGY 2 Acgme-accredited PGY 1 Categorical surgical residency programs Categorical Isaac Alty, MD Acgme-accredited Harvard Medical School surgical fellowships Abena Appah-Sampong, MD University of Chicago Pritzker School of Jake Awtry, MD non-Acgme-accredited Medicine Johns Hopkins University School of Medicine surgical fellowships Orly Farber, MD Ilaria Caturegli, MD Stanford University School of Medicine University of Maryland School of Medicine Jamie Hillas, MD Eliza Hersh, MD Geisel School of Medicine at Dartmouth Icahn School of Medicine at Mount Sinai Daniel Hoffman, MD Annabelle Jones, MD Perelman School of Medicine at the Renaissance School of Medicine at Stony University of Pennsylvania Brook University Kara Kennedy, MD Yun Jee Kang, MD University of Massachusetts Medical School Harvard Medical School Joshua Roshal, MD Sangki Oak, MD Rutgers Robert Wood Johnson Medical University of Pittsburgh School of Medicine School Alexander Ordoobadi, MD Ashley Siegel, MD Harvard Medical School University of Central Florida College of Medicine Stefanie Soelling, MD, MPH Emory University School of Medicine Sarah Tsou, MD University of California San Francisco School PGY 2 of Medicine Preliminary George Zhang, MD Johns Hopkins University School of Medicine Christian Cerecedo Lopez, MD Facultad de Ciencias de la Salud Universidad PGY 1 Anahuac, Mexico Preliminary Martin Kauke-Navarro, MD Medizinische Fakultät der Universität zu Sarita Ballakur, MD Köln, Germany Weill Cornell Medical College PGY 3 Samuel Clarkson, MD David Geffen School of Medicine at UCLA Alexis Antunez, MD University of Michigan Medical School Brian Deutsch, MD Icahn School of Medicine at Mount Sinai Rachel Atkinson, MD Geisel School of Medicine at Dartmouth Bardia Nadim, MD Northwestern University Feinberg School of Sourav Bose, MD Medicine Perelman School of Medicine at the University of Pennsylvania 19

Samuel Enumah, MD William Phillips, MD Vanessa Welten, MD Northwestern University Feinberg School of Johns Hopkins University School of Medicine Rush University Medical College Medicine James Fitzgibbon, MD Rowza Rumma, MD Christine Wu, MD Lewis Katz School of Medicine at Temple Stanford University School of Medicine University of Michigan Medical School University Paul Salem, MD Elizabeth Yates, MD James Luo, MD Mayo Clinic Alix School of Medicine University of Michigan Medical School University of Chicago Pritzker School of Medicine Research 2021 Graduates Kerri McKie, MD James Etheridge, MD Bryan Dieffenbach, MD University of Massachusetts Medical School Eastern Virginia Medical School Vascular Surgery Fellowship, Brigham and Women’s Hospital Biqi Zhang, MD Jessica Feliz, MD Harvard Medical School University of Virginia School of Medicine Anthony Haddad, MD Plastic Surgery Residency, Beth Israel PGY 4 Katherine He, MD Deaconess Medical Center University of Michigan Medical School Karan Chhabra, MD Jonathan Hills-Dunlap, MD Rutgers Robert Wood Johnson Medical Patrick Heindel, MD Pediatric Surgery Fellowship, University of School Keck School of Medicine of the University of Colorado Southern California Adam Fields, MD George Li, MD Icahn School of Medicine at Mount Sinai Frances Hu, MD Surgical Oncology Fellowship, Memorial Emory University School of Medicine Sloan Kettering Cancer Center Sameer Hirji, MD Johns Hopkins University School of Medicine Lenka Ilcisin, MD Heather Lyu, MD Harvard Medical School Breast Surgery Fellowship, MD Anderson Joshua Jolissaint, MD Cancer Center University of Virginia School of Medicine Pooja Neiman, MD David Geffen School of Medicine at Alessandra Moore, MD Abby Larson, MD University of California Los Angeles Harvard Combined Endocrine Surgery Johns Hopkins University School of Medicine Fellowship, BWH/MGH Paige Newell, MD Laura Piechura, MD Lewis Katz School of Medicine at Temple Linda Pak, MD Stanford University School of Medicine University Breast Surgery Fellowship, Memorial Sloan Kettering Cancer Center Lily Saadat, MD Brittany Powell, MD Northwestern University Feinberg School of Stanford University School of Medicine Nidhi Udyavar, MD Medicine Endocrine Surgery Fellowship, Johns Cullen Roberts, MD Hopkins University School of Medicine Bixiao Zhao, MD Warren Alpert Medical School of Brown Yale School of Medicine University Cardiothoracic Surgery Integrated (I-6) Program PGY 5 Mehida Rojas-Alexandre, MD Yale School of Medicine Program Director: Jamie Knell, MD Michael T. Jaklitsch, MD University of California San Diego School of Max Riley, MD Associate Program Directors: Medicine Washington University School of Medicine Tsuyoshi Kaneko, MD; Daniel Weiner, MD; and Jon Wee, MD Pamela Lu, MD Eva Rouanet, MD University of Massachusetts Medical School University of Massachusetts Medical School PGY 1 Arin Madenci, MD Sarabeth Spitzer, MD Phillip Allen, MD University of Michigan Medical School Stanford University School of Medicine Harvard Medical School David Mahvi, MD Megan Sulciner, MD Vivian Wang, MD University of Wisconsin School of Medicine University of Minnesota Medical School Boston University School of Medicine and Public Health Matthew Vivero, MD Danny Mou, MD Columbia University Vagelos College of Emory University School of Medicine Physicians and Surgeons 20

PGY 2 Kathryn Marcus, MD Alan Workman, MD University of Iowa Carver College of Perelman School of Medicine at the Thais Faggion Vinholo, MD Medicine University of Pennsylvania Yale University Obinna Nwosu, MD Vinay Rathi, MD John Finnigan, Jr., MD Indiana University School of Medicine Yale School of Medicine Icahn School of Medicine at Mount Sinai Chloe Warinner, MD PGY 5 PGY 3 Harvard Medical School Eric Barbarite, MD Patrick Gedeon, MD PGY 2 University of Miami Miller School of Duke University School of Medicine Medicine Allen Zhou, MD Andreas Habertheuer, MD Harvard Medical School Adeeb Derakhshan, MD Medical University of Vienna, Austria Cleveland Clinic Lerner College of Medicine Riu Han Liu, MD of Case Western Reserve University PGY 4 Johns Hopkins University School of Medicine Suresh Mohan, MD Morgan Harloff, MD Margaret Mitchell, MD Warren Alpert Medical School of Brown Kaohsiung Medical University, Taiwan Vanderbilt University School of Medicine University Kathleen Weiss, MD Danielle Reny, MD Krupa Patel, MD University of Miami Miller School of Perelman School of Medicine at the Weill Cornell Graduate School of Medical Medicine University of Pennsylvania Sciences PGY 5 Isaac Wasserman, MD Tiffany Wang, MD Icahn School of Medicine at Mount Sinai Keck School of Medicine of the University of Farhang Yazdchi, MD Southern California Shahid Beheshti University of Medical Lucy Xu, MD Sciences, Iran University of Chicago Pritzker School of Research Medicine Yifan Zheng, MD Ryan Bartholomew, MD Boston University School of Medicine PGY 3 Harvard Medical School Research Elliana DeVore (Kirsh), MD Christopher McHugh, MD, PhD Harvard Medical School Wayne State University School of Medicine Sue Wang, MD University of California San Francisco Krish Suresh, MD 2021 Graduates School of Medicine Northwestern University Feinberg School of Medicine Nicholas B. Abt, MD Hoda Javadikasgari, MD Head and Neck Oncologic and Tehran University of Medical Sciences, Iran Michael Wu, MD Reconstructive Surgery Fellowship, Harvard Medical School University of Miami Ariana Jones, MD University of California San Francisco Roy Xiao, MD Jenny X. Chen, MD School of Medicine Case Western Reserve University School of Attending Physician, Division of Medicine Comprehensive Otolaryngology, Otolaryngology Massachusetts Eye and Ear Phoebe Kuo Yu, MD Program Director, Harvard Yale School of Medicine Shekhar K. Gadkaree, MD Otolaryngology Residency Program: Facial Plastic and Reconstructive Surgery Stacey T. Gray, MD PGY 4 Fellowship, University of Minnesota Assistant Program Directors: Kevin S. Emerick, MD, and Alice Z. Ciersten Burks, MD Vivek V. Kanumuri, MD Maxfield, MD Indiana University School of Medicine Neurotology Fellowship, University of Miami PGY 1 Lauren Miller, MD Ashley L. Miller, MD Perelman School of Medicine at the Pediatric Otolaryngology Fellowship, Renata Knoll, MD University of Pennsylvania Cincinnati Children’s Hospital Medical Center Universidade do Vale do Itajaí Escola de Ciências da Saúde, Brazil Tara Mokhtari, MD Stanford University School of Medicine 21

Oral Medicine Ogonna Nnamani Silva, MD Arman Serebrakian, MD, MS University of California San Francisco School Lewis Katz School of Medicine at Temple Program Director, of Medicine University Oral Medicine Residency Program: Piamkamon Vacharotayangul, DDS, PhD PGY 2 Independent Program PGY 1 Charles Hwang, MD Junior Residents University of Michigan Medical School Lama Alabdulaaly, BDS, DMSc Eric Emberton, MD Saudi Arabia (certificate program) Ian McCulloch, MD University of Louisville School of Medicine West Virginia University School of Medicine Petros Yoon, DDS Justin McCarty, MD University of Colorado Health and Science Ricardo Ortiz, MD Lake Erie College of Osteopathic Medicine Center (certificate program) Harvard Medical School Senior Residents PGY 2 PGY 3 Ashley Ehret, MD Brittany Klein, DDS Brittany Caruso, MD Rutgers Robert Wood Johnson Medical University of North Carolina Adams School Lewis Katz School of Medicine at Temple School of Dentistry University Vishwanath Chegireddy, MD Malak Al-Hadlaq, BDS Seth Fruge, MD Morehouse School of Medicine Saudi Arabia (certificate and DMSc program) Louisiana State University School of Medicine Chief Residents PGY 3 Kimberly Khouri, MD Jason Gardenier, MD Amal Bajonaid, BDS New York University Grossman School of University of Virginia School of Medicine Saudi Arabia (certificate and MMSc program) Medicine Silviu Diaconu, MD Prazwala Chirravur, BDS PGY 4 Northwestern University Feinberg School of India (certificate program) Medicine Olivia Abbate, MD Yuanming Xu, DDS Georgetown University School of Medicine 2021 Graduates China (certificate and MMSc program) Sarah Karinja, MD Mario Aycart, MD 2021 Graduates Columbia University Vagelos College of Craniofacial Fellowship, Hospital for Sick Physicians and Surgeons Children, Toronto, ON, Canada Rossella Intini, DDS Italy (certificate program) Eric Wenzinger, MD Lisa Gfrerer, MD, PhD Medical University of South Carolina Peripheral Nerve Fellowship, Massachusetts Shaiba Sandhu, DDS General Hospital Orofacial Pain Residency Program, Mass PGY 5 General Hospital Harvard Plastic Surgery Jason Clain, MD Brent Pickrell, MD Tufts University School of Medicine Hand Surgery Fellowship, Beth Israel Program Director, Harvard Plastic Surgery Deaconess Medical Center Residency Program: Brittany Vieira, MD Kyle Eberlin, MD Northwestern University Feinberg School of Jacob Rinkinen, MD Associate Program Director: Medicine Microsurgery Hand Fellowship, Beth Israel Lydia Helliwell, MD Deaconess Medical Center Frankie Wong, MD Integrated Program David Geffen School of Medicine at the Ravi Sood, MD, MS University of California Los Angeles Hand Surgery Fellowship, University of PGY 1 Washington Chiefs Ryoko Hamaguchi, MD Harvard Medical School Timothy Irwin, MD Urology Penn State College of Medicine Harriet Kiwanuka, MD Program Director: Stanford University School of Medicine Dylan Perry, MD George Haleblian, MD University of Massachusetts Medical School 22

PGY 1 2021 Graduates 2021 Graduate Varnel Antoine, MD Alexandra J. Berger, MD David Harris, MD Harvard Medical School Genitourinary and Reconstructive Surgery, Faculty, University of Wisconsin School of University of Colorado Medicine and Public Health Christopher Magnani, MD Stanford University School of Medicine Manuel Ozambela, MD Breast Surgery Fellowship Urologic Oncology Fellowship, MD Anderson Zhiyu (Jason) Qian, MD Cancer Center Program Director: David Geffen School of Medicine at the Tari King, MD University of California Los Angeles Julie Szymaniak, MD Associate Program Director: Urologic Oncology Fellowship, University of Olga Kantor, MD, MS PGY 2 California San Francisco Yefri Baez, MD Current Fellows Ashley Newman, MD Harvard Medical School SUNY Upstate Medical University Acute Care Surgery Fellowship Vincent D’Andrea, MD 2021 Graduates Zucker School of Medicine at Hofstra/ Program Director: Northwell Reza Askari, MD Halley Vora, MD Faculty, Loma Linda University Cancer Center Kendrick Yim, MD Mohammad (Reza) Afrasiabi, MD University of California San Diego School of Acute Care Surgery Fellowship, Brigham and Meghan Garstka, MD Medicine Women’s Hospital Faculty, University of Maryland School of Medicine PGY 3 Brittany Berk, MD 2021 Graduate Cardiothoracic Surgery University of Massachusetts Medical School Fellowship Allison Brown, MD Catherine Gu, MD Faculty, NYU Langone Health Program Director: Perelman School of Medicine at the Michael T. Jaklitsch, MD University of Pennsylvania Adult Cardiac Surgery Fellowship Associate Program Directors: Tsuyoshi Kaneko, MD; Daniel Weiner, Marie Valovska, MD Program Director: MD; and Jon Wee, MD Geisel School of Medicine at Dartmouth Tsuyoshi Kaneko, MD PGY 6 PGY 4 Osama Haddad, MD Cairo University School of Medicine Leonid Belyayev, MD Tracy Han, MD F. Edward Hebert School of Medicine at the Duke University School of Medicine 2021 Graduate Uniformed Services University of the Health Sciences Kevin Melnick, MD Chikashi Nakai, MD Emory University School of Medicine Fellow, Advanced Heart Failure, Medstar, Samuel Freyaldenhoven, MD Washington, DC University of Arkansas College of Medicine Venkat Ramakrishnan, MD University of Louisville School of Medicine Advanced Laparoscopic Borami Shin, MD Fellowship University of California San Diego School of PGY 5 Medicine Program Director: Erica Ditkoff, MD Ali Tavakkoli, MD PGY 7 Columbia University Vagelos College of Associate Program Director: Physicians and Surgeons Eric Sheu, MD, PhD Kryston Boyer, DO Oklahoma State University Center for Health Gricelda Gomez, MD Jillian Angelo, MD Sciences Harvard Medical School Lewis Katz School of Medicine at Temple University Darren Bryan, MD Stephen Reese, MD University of Rochester School of Medicine Boston University School of Medicine and Dentistry Paul Feingold, MD Emory University School of Medicine 23

John Kuckelman, DO BWH/MGH Harvard Combined Sandeep Sachidananda, MD Des Moines University College of Medicine Endocrine Surgery Program St. John’s Medical College, Bangalore, India Michael Lee, MD Program Director: 2021 Graduate University of Pittsburgh School of Medicine Matthew A. Nehs, MD Kostastinos Poulikidis, MD 2021 Graduates Alessandra Moore, MD Attending, Danbury Hospital, CT University of Massachusetts Medical School Marko Boskovski, MD Surgical Critical Care Fellowship Assistant Professor of Cardiac Surgery, 2021 Graduate University of California San Francisco Program Director: Rajshri Gartland, MD Reza Askari, MD Anthony Cipriano, MD Faculty, Endocrine Surgery, Massachusetts Attending Surgeon, Geisinger Health General Hospital Adam Golden, MD Systems, PA Tulane University School of Medicine Endovascular Cardiac Surgery Mia DeBarros, MD Fellowship Crystal Kyaw, MD Attending Surgeon, Thoracic Surgery, Zucker School of Medicine at Hofstra/ Madigan Army Medical Center Program Director: Northwell Tsuyoshi Kaneko, MD Julius Ejiofor, MD Constantine Saclarides, MD Attending Surgeon, Cardiac Surgery, Baylor William Shi, MD University of Miami Miller School of Medicine Scott & White, Dallas, TX University of Melbourne Medical School, Australia Stephanie Yee, MD Desiree Steimer, MD Rowan University School of Osteopathic Associate Surgeon, Division of Thoracic 2021 Graduate Medicine Surgery, Brigham and Women’s Hospital Morgan Harloff, MD 2021 Graduates Cardiothoracic Surgery Thoracic Integrated Residency, Brigham Transplant Fellowship and Women’s Hospital Mohammad “Reza” Afrasiabi, MD Acute Care Surgery Fellowship, Brigham and Program Director: General Thoracic Surgery Women’s Hospital Antonio Coppolino, MD Fellowship Laura Hyde, MD Bassem Ayyash, MD Program Director: Faculty, Lincoln Medical Center, Bronx, NY Lithuanian University of Health Sciences, Michael T. Jaklitsch, MD Lithuania Renaldo Williams, MD Roger Zhu, MD Acute Care Surgery Fellowship, Johns 2021 Graduate SUNY Downstate College of Medicine Hopkins University Hunbo Shim, MD 2021 Graduates Surgical Clinical Nutrition Attending, Ewha Womans University Medical Support Fellowship Center, South Korea Jessica Della Valle, MD Attending, Pardee UNC Health, NC Program Director: Colorectal Surgery Fellowship Malcolm Robinson, MD Melanie Lighter, MD Program Director: Attending, University of Illinois College of Kanwal Bains, MD Nelya Melnitchouk, MD, MSc Medicine at Chicago Dayanand Medical College, India Miquell Miller, MD Minimally Invasive Thoracic Surgical Oncology Fellowship Stanford University of Medicine Surgery Fellowship Program Director: 2021 Graduate Program Director: Mark Fairweather, MD Jon O. Wee, MD Robert Malizia, MD Surgeon, Central Valley Colon and Rectal Daniel Solomon, MD S2u4rgical Associates, Fresno, CA Yale University School of Medicine

PGY 6 Second-Year Fellows Andrew Servais, MD Tufts University School of Medicine Zhi Fong, MD Filipe de Carvalho, MD Sidney Kimmel Medical College at Thomas University of Porto, Rebecca Scully, MD Jefferson University Portugal Geisel School of Medicine at Dartmouth PGY 7 Madhur Nayan, MD 2021 Graduate Faculty of Medicine and Health Sciences at Thinzar Lwin, MD McGill University, Montreal, Canada Andrew Soo Hoo, MD New York Medical College Vascular Surgeon, Dwight D. Eisenhower 2021 Graduates Army Medical Center, Augusta, GA 2021 Graduate Eugene Cone, MD Visiting Professors Winta Mehtsun, MD Urologic Oncologist, Urology of Indiana Attending, University of California San Gerald and Elaine Schuster Distinguished Francisco Alexander Cole, MD Lecturer in Thoracic Surgery Associate Surgeon, Division of Urology, Haiquan Chen, MD Urological Oncology Fellowship Brigham and Women’s Hospital Fudan University Shanghai Cancer Center Program Director: Vascular Surgery Fellowship Hechtman Trauma Lecturer in Surgery Steven L. Chang, MD, MS David A. Spain, MD Program Director: Stanford University School of Medicine First-Year Fellows Matthew Menard, MD Associate Program Director: Lawrence H. Cohn Visiting Professor in Ikena Madueke, MD Marcus Semel, MD Cardiac Surgery University of Illinois College of Medicine at Ralph J. Damiano, Jr., MD Chicago Bryan Dieffenbach, MD Washington University School of Medicine in University of California San Diego School of St. Louis Affan Zafar, MD Medicine Baylor College of Medicine Announcements tract and soft-tissue sarcomas. In (CLEA) in the Department of Surgery. addition to research on treatment The CLEA’s mission is to support the Mark Fairweather, MD, Named outcomes for sarcoma, including department’s commitment to providing Associate Program Director of the retroperitoneal sarcomas and a positive learning environment for Brigham General Surgery Residency gastrointestinal stromal tumors, he all trainees—students, residents Program also serves as an executive officer and fellows. This role is designed to for the Alliance Foundation Trials, serve as a neutral, third party to hear Dr. Fairweather is a graduate of where his work focuses on developing comments and feedback about the Hanover College and received his and validating methods of capturing teaching and learning environments. medical degree from the University high-quality real-world data alongside The CLEA serves as a confidential of Louisville School of Medicine. He ongoing clinical trials. resource for trainees and will be an completed a residency in general impartial, private resource to report surgery at Brigham and Women’s Jamie Robertson, PhD, MPH, Appointed and seek assistance for concerns. The Hospital, followed by a fellowship in Clinical Learning Environment Advocate CLEA will be a resource to educators complex general surgical oncology at (program directors, faculty, residents Massachusetts General Hospital and In addition to her role as director of and others in a teaching role), staff and Brigham and Women’s Hospital. Innovation in Surgical Education, Dr. administration to discuss and resolve Robertson has assumed the role of learning environment concerns. Dr. Fairweather’s clinical interests clinical learning environment advocate include cancers of the gastrointestinal The CLEA will also provide trainees in small programs, such as fellowships, a place to provide feedback and relay information as appropriate to program leadership. 25

Research Brigham and Women’s Hospital is an international powerhouse in biomedical research dedicated to pioneering discoveries that will translate into new prediction methods, treatments, and cures for the world’s most devastating and complex diseases. 492 445 26 active protocols research funds active clinical trials 58 231 research fellows active grants and contracts $43,231,910 research spending Selected Grants Selected Clinical Trials Alliance: Administrative supplement A15184 irAE biobanking Neoadjuvant combination treatment with pembrolizumab and PI: Monica Bertagnolli, MD defactinib for malignant pleural mesothelioma Sponsor: NIH PI: Raphael Bueno, MD Grant Amount: $2,759,673 Sponsor: Merck & Co. A layered examination of the patient experience to elucidate the A novel approach to lower extremity amputation to augment role of palliative care in surgical care for seriously ill adults volitional motor control and restore proprioception PI: Zara Cooper, MD, MSc PI: Matthew J. Carty, MD Sponsor: NIH Sponsor: Department of Defense (USAMRAA) Grant Amount: $3,256,125 A novel approach to lower extremity residual limb revision to Androgen receptor pathway inhibition through targeting PARP- augment volitional motor control, restore proprioception and 2 in castration-resistant prostate cancer reverse limb atrophy PI: Li Jia, PhD PI: Matthew J. Carty, MD Sponsor: NIH Sponsor: Department of Defense (USAMRAA) Grant Amount: $2,047,315 CTA: Transcatheter replacement of stenotic aortic valve through A microbiome-dependent bile acid metabolite improves type 2 implantation of ACURATE in subjects inDicatEd for TAVR diabetes PI: Tsuyoshi Kaneko, MD PI: Eric Sheu, MD, PhD Sponsor: Boston Scientific Corporation Sponsor: NIH-NIDDK G2r6ant Amount: $3,340,983

Zara Cooper, MD, MSc, Awarded function of FOXA1 is its modulation a $3.3M National Institutes of by poly-(ADP-ribose) polymerase 2 Health Grant (PARP-2), conventionally known as a DNA repair protein. Studies have Over 1 million older adults with demonstrated that PARP-2 is a critical serious illness have major surgery or component in AR signaling through severe trauma each year, and palliative interacting with FOXA1 and facilitating care delivered alongside surgical care AR recruitment to prostate-specific can help relieve patient suffering, enhancers. The overall objective improve postoperative outcomes and of this project is to determine the reduce health care utilization. Although molecular mechanisms by which seriously ill surgical patients benefit selective targeting of PARP-2 inhibits from palliative care, they are less CRPC growth through disruption of likely than other patients to receive FOXA1 function and define PARP-2 as it. The proposed study will provide an an alternative therapeutic target for innovative and layered examination of CRPC. The successful implementation the role of palliative care in surgery in of this project will greatly advance the order to directly inform bedside clinical understanding of multifaceted biology decisions and the implementation of of PARP proteins and their evolving targeted palliative care interventions impact on cancer therapeutics. to improve care for older seriously ill More specifically, the results from surgical patients. the proposed research are expected to provide a strong basis for future Li Jia, PhD, Awarded a $2M development and clinical application of National Institutes of Health selective PARP-2 inhibitors benefiting Grant patients with incurable metastatic castration-resistant prostate cancer. Androgen receptor (AR) is a ligand- activated transcription factor and a Eric Sheu, MD, PhD, Awarded driver of prostate cancer (PCa) growth a $3.3M National Institutes of and progression. Understanding Health Grant the molecular mechanisms of AR- mediated transcription is a key for Dr. Sheu’s group has identified a the development of novel therapeutic bile acid metabolite, CA7S, that is strategies for both castration-sensitive generated by bariatric surgery and prostate cancer (CSPC) and castration- has anti-diabetic properties. This resistant prostate cancer (CRPC). It study’s goals are to evaluate the CA7S is well-known that AR transcriptional metabolite as a novel therapy for type 2 activity is prominently dictated by the diabetes; uncover how CA7S production transcription activator FOXA1, which is regulated by the gut microbiome; acts as a pioneer factor opening the and determine the contribution of condensed chromatin and facilitating CA7S to type 2 diabetes remission, the recruitment of AR. Genome following bariatric surgery. The study sequencing studies have revealed that is funded by the NIH National Institute FOXA1 is one of the most frequently of Diabetes and Digestive and Kidney mutated genes in primary PCa and Diseases (NIDDK), whose mission even more common in metastatic is to conduct and support medical CRPC. Aberrant FOXA1 function is research and research training and to implicated in PCa development and disseminate science-based information progression likely through its impact on diabetes and other endocrine and on AR signaling. Therefore, inhibition metabolic diseases; digestive diseases, of AR through targeting FOXA1 is a nutritional disorders, and obesity; promising therapeutic approach for and kidney, urologic, and hematologic CRPC. However, to date FOXA1 has diseases, to improve people’s health been deemed undruggable. It was and quality of life. recently reported that critical to the 27

The Laboratory for Surgical and Metabolic Research The intersection of science and surgery In the Laboratory for Surgical and Pioneering the field Bent Brigham Hospital. In the newly Metabolic Research at Brigham and of surgical metabolic minted Laboratory for Biochemistry Women’s Hospital, the tradition of research and Metabolism in Surgery, Dr. scientific excellence and commitment Moore pioneered the study of the to finding novel solutions to stubborn The laboratory traces its heritage metabolic impact of surgery and problems in surgery and metabolism to the earliest days of surgical trauma, focusing much of his early dates back decades and continues metabolic research by Francis D. work on understanding the body’s today. Under the leadership of three Moore, MD, third surgeon-in-chief of composition and the metabolic surgeon-scientists with distinct but the Brigham, who in 1948 opened a responses of surgical patients. Dr. overlapping research interests, the research laboratory focused on the Moore, a prolific researcher and author, laboratory carries on its long and biochemical and metabolic impacts wrote his textbook, Metabolic Care of distinguished tradition of pioneering of surgery at what was then the Peter the Surgical Patient, first published treatments and discoveries. in 1959, based on this research. His 28

contributions to the field of surgery improved gut nutrient absorption idea for treating patients with short rewarded him with may honors. and restored muscle mass following bowel syndrome. He appeared on the cover of TIME wasting diseases. His pioneering magazine in 1963, and his textbook work led to multiple patents and FDA By the early 2000s, the intersection remained the standard surgery approval for the use of glutamine in of surgery, nutrition and metabolism text for nearly three decades. More patients with short bowel syndrome. began to shift with the discovery importantly, his pioneering research Under Dr. Wilmore, the laboratory’s that gastric bypass surgeries not transformed the care of surgical name was changed to the Laboratory only reduce weight but also improve patients for generations to come. for Surgical Metabolism and Nutrition diabetes. With Ali Tavakkoli, MD, to better reflect the new focus in the chief of the Division of General and The culture of academic rigor that area of surgical nutrition. He became GI Surgery and co-director of the Dr. Moore established within the the Frank Sawyer Professor of Surgery Center for Weight Management and Department of Surgery helped to at Harvard Medical School in 1989 until Wellness at the Brigham, taking over define modern academic surgery at his retirement in 2003. the leadership of the laboratory in the Brigham and was carried on by 2006, the laboratory’s focus changed many subsequent surgeon-scientists, Following Dr. Wilmore, Danny O. from studying the metabolic impact of who made lasting contributions to the Jacobs, MD, took over directorship of surgery and trauma and approaches advancement of gastrointestinal and the laboratory, focusing his research to optimize post-surgical nutrition, to metabolic surgery (see timeline below). on using nuclear magnetic resonance understanding the anti-diabetic effects Dr. Moore retired from his post at the to assess the effects of malnutrition, of bariatric operations, with the goal of Brigham in 1976 but continued on the starvation, infection and injury on organ developing less-invasive alternatives faculty of Harvard Medical School function and metabolism. Following that replicated the surgical success. as a professor of surgery until 1981 Dr. Jacob’s departure to become the and then as the Moseley Professor chief of surgery at Creighton University In 2015, the lab was reestablished Emeritus, a position he retained until School of Medicine and subsequently under a new name, the Laboratory for his death in 2001. He was elected to chair of the Department of Surgery Surgical and Metabolic Research, to the National Academy of Sciences at Duke University Medical Center, integrate the investigative endeavors in 1981. Stanley W. Ashley, MD, led the group in surgical metabolism with research with a focus on exploring the role of in all other aspects of gastrointestinal In 1979, Douglas W. Wilmore, glucagon-like peptide 2 (GLP-2) in and general surgery, including surgical MD, joined the faculty at Peter Bent augmenting intestinal morphology and immunology and inflammation. Brigham Hospital to continue the work function. His work contributed to the of Dr. Moore in the area of surgical eventual development and marketing Today, the laboratory’s research metabolism. He had been involved in of this peptide as a novel therapy for programs are led by the team of Dr. some of the early work on the use of patients with short bowel syndrome. Tavakkoli; Eric G. Sheu, MD, PhD, parenteral nutrition. Dr. Wilmore and In parallel, Edward E. Whang, MD, co- a minimally invasive and bariatric his team developed modern techniques director of the lab, while contributing surgeon at the Brigham and assistant to measure glutamine and described to the studies on GLP-2, was part of professor of surgery at Harvard the response of this amino acid to a collaborative team that aimed to Medical School; and James Yoo, MD, acute illness. His group was the first to advance the development of a tissue- a colorectal surgeon in the Section demonstrate that glutamine reduced engineered small intestine as a novel of Colon and Rectal Surgery at the infection rates in critically ill patients, Brigham and the Dana-Farber/Brigham and Women’s Cancer Center. Laboratory for Laboratory for Surgical Metabolism and Nutrition Laboratory for Biochemistry and Surgical and Metabolism in Surgery Metabolic Research Laboratory 1948 ― 1979 1979 ― 1997 1997 ― 2006 2006 ― 2015 2015 ― present Groundbreaking Early work on parenteral Intestinal adaptation and Anti-diabetic effects Integrating surgical research on the nutrition newtreatments for short of bariatric surgery metabolism research impact of surgery bowel syndrome and replicating with other aspects on metabolism and Metabolic effects of this effect without of gastrointestinal nutrition malnutrition, stress, infection Role of GLP-2 in augmenting surgery and general surgery, and injury on organ function intestinal adaptation surgical immunology, and metabolism and inflammation Pioneering, collaborative Founded and led by Francis D. Moore, MD workon a tissue-engineered small intestine 29

From surgical 2 diabetes patients had an immediate resolution after gastric bypass surgery metabolic research improvement in their type 2 diabetes in order to do just that. Studies showing to research on after surgery,” Dr. Tavakkoli said. In fact, that gastric bypass surgery eliminates metabolic surgery nearly 40% of patients with diabetes nutrient exposure in the duodenum and who undergo bariatric surgery leave the proximal bowel suggest that these two “The first 50 years of the laboratory’s hospital no longer needing anti-diabetic areas have effects on metabolic and work focused on studying the metabolic medications. He adds that, by now, glucose control. In addition, research impact of surgery and trauma, as well more than 11 randomized trials have on a duodenojejunal endoscopic sleeve as ways to provide and optimize the demonstrated that bariatric surgery to prevent contact between food and nutritional status of malnourished is better at treating diabetes than the the duodenal mucosa has shown that surgery patients and those with short standard-of-care medications and isolation of the proximal bowel from bowel syndrome,” Dr. Tavakkoli said. “By treatment algorithms. nutrient exposure can lead to dramatic the early 2000s, the epidemic of obesity improvements in type 2 diabetes. had led to the establishment of the field The benefits of of bariatric surgery as an important metabolic surgery “We collaborated with Jeff Karp in specialty that not only impacts weight, without surgery the Division of Engineering in Medicine but also overall health,” he added. at the Brigham to find a material “Our goal is to develop less invasive that would coat the proximal bowel The subsequent observation that alternatives that can replicate the to prevent food interaction with the gastric bypass surgery not only reduces metabolic benefits of surgery,” Dr. proximal bowel mucosa,” Dr. Tavakkoli weight, but also improves type 2 Tavakkoli explained. said. “We specifically explored ways diabetes independent of weight loss, to transiently coat the proximal bowel, led to a new era of metabolic surgery, How do you mimic the effects of so when food passes through the with the primary goal of operating on gastric bypass without actually doing intestines, the mucosa doesn’t see the the gastrointestinal tract and correcting the surgery? Dr. Tavakkoli and his team food.” The coating would need to be metabolic derangements. have been investigating the underlying transient, so that people are able to molecular mechanism of diabetes take a multivitamin at a different time to “It was remarkable to see how type avoid developing vitamin deficiency. Their animal studies using modified 30

forms of sucralfate as a barrier in the systemic glucoregulatory effects, while colorectal cancer, such as colitis- small bowel, were published in Nature that the lab is working to develop for associated cancer.” Dr. Yoo’s team is Materials. Sucralfate, a water-insoluble type 2 diabetes, obesity and intestinal trying to determine what changes in the salt, has been used for more than 30 inflammatory disease. colonic environment are putting these years to treat gastric and duodenal patients at higher risk so that they can ulcers. However, it does not adhere In another first, this research team lower their risk. to healthy intestinal mucosa. In their elucidated a microbiome-dependent studies, sucralfate was among the most pathway by which sleeve gastrectomy “We know that the gut microbiome effective barriers to glucose permeation increases CA7S production. They found plays a big role in colon cancer,” Dr. and its barrier effect lasted a few hours. that CA7S is produced in the liver by Yoo said. Specifically, imbalance in the In collaboration with Dr. Karp’s group, a specific sulfotransferase enzyme in gut microbial population is known to the team further engineered sucralfate response to the microbial metabolite, be a major driver of colitis and colitis- to create a novel compound, which lithocholic acid (LCA), transported associated cancer. As noted previously, they named LuCI (Luminal Coating from the gut to the liver by the portal Dr. Sheu’s group has shown that the gut of the Intestine), that binds to healthy vein. By performing a microbiota microbiome is profoundly altered after intestinal mucosa and forms a barrier transplant from sleeve gastrectomy sleeve gastrectomy. “We are merging to nutrient absorption. Their CT imaging mice into germ-free mice, Dr. Sheu the study of inflammation-associated studies showed that LuCI was able to and his team found that the bariatric cancer and sleeve gastrectomy’s form a luminal coating in the proximal surgery microbiome can recreate effects on the microbiome to study bowel and result in a significant this gut-liver pathway, leading to how sleeve gastrectomy affects the lowering of the glucose tolerance curve CA7S synthesis and GLP-1 secretion. development of tumors in colitis- after an oral gavage. This research has Together, these discoveries represent associated cancer,” Dr. Yoo said. now been spun off into the start-up the first molecular pathway that biotech company, AltrixBio. causally connects the microbiome to Using a mouse model of colitis- the improvement of diabetes following associated cancer, the research Exploring how bariatric surgery. team examined sleeve gastrectomy’s bariatric surgery effect on colitis-associated cancer affects the “We are also trying to understand the development and progression via microbiome and beneficial consequences of surgery on alterations in the gut microbiome. immune response the immune system,” Dr. Sheu said. It Using 16S RNA sequencing, they was already known that obesity leads examined stool samples to identify “Our research centers on how to dysregulation of the immune system the normal population of microbes at bariatric operations work to eliminate and chronic inflammation. In a study of baseline and after sleeve gastrectomy type 2 diabetes independent of weight patients undergoing bariatric surgery, or sham surgery to see if there was over loss, as well as the surgery’s impact on Dr. Sheu found dramatic changes in or under expression of certain bacteria the immune system,” Dr. Sheu said. immune cell number, function and species after surgery. The mice that metabolism that occurred early after underwent sleeve gastrectomy had Previous research had identified surgery. Using mouse models of sleeve greater severity of colitis, more tumors increases in glucagon-like peptide 1 gastrectomy, the group has observed and marked increases in microbial (GLP-1), a circulating incretin hormone, that bariatric surgery alters the taxa linked to colitis. Moreover, when and changes in systemic bile acids in frequency and function of specific the sham-treated mice received patients after gastric bypass or sleeve B cells and their antibody products, cecal microbiota transplant from the gastrectomy. Dr. Sheu, in collaboration which they believe play an important sleeve gastrectomy-treated mice, they with Dr. Sloan Devlin’s group at Harvard role not only in glucose metabolism, developed significantly more severe Medical School, were the first to but also the body’s response to colitis and a five-fold increase in identify that the bile acid molecule, infection and vaccines. tumor burden, thereby confirming the CA7S, is increased in the gut after causal role of the microbiota in sleeve sleeve gastrectomy, the most common “Different elements in the GI tract gastrectomy-mediated promotion of bariatric operation performed today, in regulate its function in health and colitis-associated cancer. mice and humans. They have gone on disease,” Dr. Yoo explained. “Our to discover that CA7S regulates glucose research aims to understand how the Training the next metabolism by inducing GLP-1 secretion interaction occurs.” generation of by binding the bile acid receptor, TGR5. surgeon-scientists The team has found that CA7S exerts “Overall, sleeve gastrectomy reduces the risk of developing many cancers Young surgeon-scientists are at the by approximately 30 to 50%,” Dr. heart of the innovative environment that Yoo said. “But patients with chronic inflammatory conditions who undergo sleeve gastrectomy are at greater risk for developing inflammation-associated 31

has flourished in this laboratory. Investigating the Role of Bariatric Surgery in Colitis-Associated Cancer “The number of surgeons doing Active Grants/Awards Recipient Recipient basic science is declining nationally,” Dr. Ashley, Frank Sawyer Professor of Role of Meal Timing in Efficacy of Bariatric Ali Tavakkoli Surgery at Harvard Medical School, Surgery in Obese Individuals Frank Scheer said. “Here, however, we have a solid group of surgeons who have chosen NIH-NHLBI: R01 HL140574 to pursue academic research.” These faculty members have inspired many Shared Decision Making for Bariatric Surgery in Ali Tavakkoli Brigham residents to pursue research Patients with Severe Obesity careers in this field. Executive Stakeholder Advisory Group Member “Surgery residents have been critical to the success of our program,” Research Training in Alimentary Tract Surgery Ali Tavakkoli Dr. Sheu said. “People like David Harris and James Luo have laid the Director of Surgical Technology and Innovation groundwork and driven these important track, Executive Committee projects forward. They bring a unique perspective of clinical knowledge Member of what is important in surgical research models and take projects A Microbiome-Dependent Bile Acid Metabolite Eric Sheu to the next level.” Improves Type 2 Diabetes “The number one thing this lab NIH 1R01DK DK126855-01 (NIDDK) has provided me is mentorship,” Dr. David Harris, who spent two years as American Surgical Association Foundation Eric Sheu a research fellow in the laboratory, Fellowship Award resulting in multiple publications and awards, including the American College Characterization of a novel, gutrestricted of Surgeons’ Research Excellence metabolite that links the microbiome and the Award, said. “There are many people anti-diabetic effects of bariatric surgery in this lab engrossed in research and mentors that understand the value that Pilot Grant, Blavatnik Biomedical Accelerator Eric Sheu different perspectives can bring to the questions we are trying to answer.” Development of synthetic analogs of a sleeve gastrectomy–induced metabolite “This lab has always been a think as a novel therapy for type 2 diabetes tank for high-impact research in and obesity. surgery and investigators who want to think about the complex problems surgeon-scientists on both the national collaboration,” Dr. Yoo said. within the field of surgery,” Dr. Harris and international levels to innovate new “Understanding of the immunologic said. “I’ve been able to explore new approaches to gastrointestinal facets of metabolic research through and metabolic diseases,” Dr. Tavakkoli and cancer effects of bariatric surgery collaborations with scientists at said. “Our faculty have been invited will be critical in terms of knowing Harvard, the Joslin Diabetes Center and internationally to give talks on our when to have surgery and when not to Beth Israel Deaconess Medical Center.” research, and some of our past fellows have surgery,” Dr. Sheu said. are successful academic leaders in the The laboratory also has a strong UK and China.” “As surgeon-scientists, we have international standing, including a a critical role,” Dr. Tavakkoli said. longstanding relationship with the Seeking solutions “We have access to valuable clinical Cambridge surgical training program in through research observations and a laboratory with England, which sponsors a UK trainee collaboration a rich and unique research history to join the lab for two to three years of that inspires you to ask the questions research. Dr. Tavakkoli was himself one “This is an interesting lab, because ‘How?’ and ‘Why?’” of these trainees who joined the lab in we have different scientific interests 1998, under Dr. Ashley and Dr. Whang, within the GI space, but sharing the As the obesity pandemic and parallel after receiving his medical degree from same physical space allows for greater growth in metabolic disorders continue the London Hospital Medical College to expand despite multiple efforts, this in England. laboratory continues its long tradition of pioneering novel solutions to both “We’re training the next generation of persistent and evolving challenges in surgery and metabolism. 32

Center for Surgery and Public Health (CSPH) Making surgery safer, more patient-centered, and more accessible in the U.S. and around the world. One of the founding programs in the delivery of safe, high-quality and and screening delays both on clinical surgical health services research, equitable patient-centered care. outcomes and patient experience. the Center for Surgery and Public They have also made the case for Health (CSPH) is a national leader in Over the past year, CSPH researchers operationalizing equity in health the science of surgical care delivery. have applied their expertise to the system emergency response, using the Exploring surgery through a public COVID-19 pandemic, conducting experiences at Brigham and Women’s health lens, research at CSPH expands research to assess the pandemic’s Hospital to build a case study on how to beyond the operating room, examining wide-ranging impacts on the U.S. explicitly integrate equity into Hospital interactions within the health care surgical system, including changes to Incident Command Systems guidelines. system and the social determinants health care infrastructure, payment and lived experiences of patients. systems, safety standards, clinical With the COVID-19 pandemic Rising to the challenges of the past training and population health. accelerating the transition to digital year, CSPH has continued its work at CSPH researchers have contributed health, CSPH researchers are working the intersection of surgery and public to modeling hospital capacity and with multidisciplinary providers to health, producing research that informs system response to set national and address the equity gap in telemedicine policy and program development for state governmental policies and have for patients with limited English examined the impact of cancer surgery proficiency (LEP). Using findings from publications fellows graduated active fellows 33

the FORTE study, a multi-institutional caregivers is paramount to aligning researchers are looking at how to research collaboration based at CSPH, surgical care with patient goals, better tailor these interactions for other which collects, analyzes and interprets especially for seriously ill and older patient groups, including patients with long-term patient centered outcomes patients. This relationship dynamic has dementia and those who identify as after trauma surgery, our researchers been severely hindered by disruptions sex and gender minorities, to improve designed the Non-English-Speaking in the health care setting during the patient outcomes and experiences. Trauma Survivors (NESTS) Pathway--a COVID-19 pandemic. CSPH researchers Mass General Brigham United Against have examined the experience of Bringing together a diverse team of Racism initiative. Its primary goal is older and seriously ill patients and multidisciplinary experts, CSPH has to increase rates of outpatient mental developed protocols for how to have strived to make surgery safer, more health evaluation for non-English shared decision-making conversations patient-centered, and more accessible speaking survivors of traumatic injury when caregivers and family cannot in the U.S. and around the world, with dealing with symptoms of depression, be present. Following up on previous research that responds to the inequities anxiety or PTSD. studies to identify best practices for of the past, confronts the challenges of using advance care planning (ACP) in today and anticipates the possibilities The shared decision-making process achieving patient care goals, CSPH of tomorrow. among clinicians, patients and their Selected Grants among sexual and gender minority injury using smartphone-based digital (SGM) individuals and their caregivers, phenotyping.” This study will determine Zara Cooper, MD, MSc, was awarded to understand ACP discussion the feasibility of using smartphone- $3.3M from the National Institutes between providers and individuals based digital phenotyping for routine of Health for the study, “A layered who are SGM to help inform patient- collection of post-discharge functional examination of the patient experience centered interventions to facilitate outcomes after traumatic injury. to elucidate the role of palliative care high-quality ACP discussions among in surgical care for seriously ill adults.” this population.” The proposed Regan Bergmark, MD, was awarded The proposed study will provide an research study will inform policy and $34,500 for her study, “Disparities in innovative and layered examination of practice by 1) understanding factors access to experienced surgeons.” CSPH the role of palliative care in surgery in associated with ACP discussions researchers anticipate that entrenched order to directly inform bedside clinical among transgender or gender nonbinary referral patterns are a primary driver decisions and the implementation of Medicare beneficiaries using claims of persistent racial/ethnic segregation targeted palliative care interventions data and 2) understanding the needs, to specific surgeons and hospitals in to improve care for older seriously ill experiences and challenges facing self- America. The goal is to understand surgical patients. identified SGM adults and caregivers these referral patterns by first around ACP. demonstrating differences in the level Zara Cooper, MD, MSc, was awarded of experience of surgeons accessed $435,000 from the Henry M. Jackson Amy Bulger, RN, MPH, and Rachelle by different patient populations with Foundation to extend the “Comparative Bernacki, MD, MS, were awarded quantitative methods, and then using effectiveness and provider-induced $198,228 from the Rita & Alex Hillman qualitative methods to understand demand collaboration (EPIC)” study with Foundation for their study “Serious patient decision-making around choice the Uniform Services University. This illness conversation outreach in the of surgeon and hospital. collaboration has focused on studying time of COVID-19.” The proposed study some of the most pressing health care employs nurse care coordinators in the Robert Riviello, MD, MPH, was awarded challenges faced by military and civilian integrated Care Management Program $6,831 from a Harvard Medical School/ populations, including increasing health (iCMP) at the Brigham to ensure Ariadne Labs Spark Grant for the care costs, comparative effectiveness vulnerable patients have opportunities project, “Protocols for safe postpartum and outcomes, epidemiology, quality to have serious illness conversations care at home for women delivering and practice improvement, health care and share their values and goals. by cesarean section in rural Africa.” disparities. The goal of this project is to develop Juan Herrera-Escobar, MD, MPH, was standardized protocols for postpartum Joel Weissman, PhD, was awarded awarded $28,000 from the Brigham care for women delivering via c-section $99,460 from the National Institutes Internal Stepping Strong Award for his to support safe and affordable home- of Health (NIH) for his supplemental study, “Routine collection of post- based follow-up in rural Africa. study, “Advance care planning (ACP) discharge functional outcomes after 34

Patient-Reported Outcomes, Value & Experience(PROVE) Center To leverage leading-edge techniques to transform the collection, analysis and feedback of patient-reported outcomes and experiences at Mass General Brigham and around the world. Year At A Glance Business school (HBS) and the improvement across the U.S., identify International Consortium of Outcomes best practices for implementation of Welcomed new associate director, Research (ICHOM). imPROVE consists such a program and explore whether Maria Edelen, PhD, who is a of a patient-facing web application and PROs can reliably identify quality psychometrician and health policy clinician- and administrative-facing improvement opportunities. researcher with a specific focus on portals, developed through iterative patient-reported outcomes. cycles of feedback from patients and Understanding health-related quality key stakeholders. As of June 2021, of life and psychological well-being Expanded center support to include imPROVE was implemented within during the COVID-19 pandemic. The five Brigham surgery faculty members, the breast oncology and plastic COVID-19 pandemic has resulted in one research faculty, a postdoctoral surgery services across four sites unprecedented, sudden interruptions or research fellow, two research (Dana-Farber Cancer Institute Main alterations to the general population’s assistants, a program manager and an Campus, Dana-Farber Cancer Institute lifestyle, fundamentally altering informatician. Chestnut Hill, Brigham and Women’s how Americans live their lives. Hospital Main Campus, Brigham and These sudden changes may impose Supported 14 research fellows and Women’s Faulkner Hospital) and 22 significant consequences on ones’ residents, 9 research trainees and care team members (surgeons, nurse overall health-related quality of life 8 visiting scholars from the United practitioners and physician assistants). (HRQOL) and psychological well- Kingdom, Germany and the Netherlands To date, over 900 patients have been being. This study aims to understand over the course of three years. enrolled. the impact of Covid on self-reported HRQOL and psychological well- Published 70 papers in peer-reviewed Scaling and spreading electronic being (depression and anxiety) and journals that are related to patient- capture of patient-reported outcomes to identify factors associated with reported outcome measures (PROMs) using a national surgical quality the experiences of stigma. HRQOL development and implementation and improvement program (NSQIP). and psychological well-being were comparative effectiveness studies that Incorporating the patient’s perspective assessed using the PROMIS 10 Global use PROMs to evaluate outcomes. to evaluate surgical quality has yet to Health Questionnaire, the Patient be achieved in the U.S. and represents Health Questionnaire 9 item (PHQ-9) Implemented imPROVE, an innovative a tremendous unrealized opportunity and the Generalized Anxiety Disorder electronic patient-reported data (PRD) for continuous quality improvement. 7-item (GAD-7). In May 2020, the team collection platform developed by the This is a $1.5M AHRQ R18 grant for distributed the baseline survey through PROVE team, within the breast oncology which Andrea Pusic, MD, will serve as an online crowdsourcing platform and service at Dana-Farber Cancer Institute co-PI, along with Clifford Y. Ko, MD collected data from over 2,000 U.S. (DFCI) and the plastic surgery service at (American College of Surgeons), and residents. The baseline survey results Brigham and Women’s Hospital. Larissa Temple, MD (University of are currently under consideration Rochester Medical Center). The study for publication at a peer-reviewed Key Research Initiatives aims to scale and spread the routine journal and the follow-up data is health IT-enabled collection of PROs being analyzed. imPROVE is a new electronic platform from ambulatory surgical patients that was developed in collaboration using a well-established national Development and implementation with breast cancer care providers, surgical quality improvement registry of a patient-reported outcome mea- patients and patient advocates at program. To date, over 2,400 patients sure for gender-affirming treatments Brigham and Women’s Hospital and in nine centers have contributed data. (GENDER-Q). Hormone treatment and Dana-Farber Cancer Institute (DFCI), Results of this research will accelerate gender-affirming surgery provided to as well as members of the Harvard the uptake of using PROs for quality transgender and gender diverse people 35

can dramatically change how the face, reported outcome measure (PROM) Institute (NCI) National Clinical Trials body and genitals look and function. to understand the effectiveness of Network, and nine studies, many However, a critical barrier to measuring headache treatment and its impact with international scope, that are outcomes for such gender-affirming on quality of life. To date, in-depth sponsored by the Alliance Foundation health care is the lack of a patient-re- qualitative data from 18 patients has in collaboration with non-NCI partners. ported outcome measures (PROs). To been conducted. Qualitative interviews address this unmet need, the Canadian will continue until saturation of Alliance researchers across the Institute of Health Research (CIHR) has concepts is achieved. U.S. demonstrated exceptional provided Anne Klassen, MD, the PROVE resourcefulness and commitment to Center collaborator at McMaster Uni- Development of a condition-specific maintaining access to clinical trials versity, with grant funding ($2,080,000 patient-reported outcome measure during the COVID-19 pandemic. Using CDN) to perform an international multi- for patients undergoing vascularized telehealth visits, including virtual phase program of research to develop composite tissue allotransplantation consenting processes, and a variety and implement a patient-reported of the face. Facial transplant surgery of strategies to support at-home care outcome measure for gender-affirming seeks to restore function, as well as delivery, the overall accrual to Alliance treatments (GENDER-Q). This award will improve psychological health and trials was maintained at pre-pandemic be used to cover the development of a social participation for patients who levels for the time from January 2020 to PROM for gender-affirming treatment have experienced catastrophic injuries. October 2021. (GENDER-Q) and its implementation Despite high clinician-reported success into clinical practice. The GENDER-Q rates, the lack of validated PROMs The Alliance Foundation enters its will provide a comprehensive set of that capture important concepts for third year of funding member research independently functioning scales that these patients makes it impossible in response to the group’s strategic cover concepts such as appearance, to accurately measure the extent to priorities. Proposals are funded up to body image, physical, sexual and psy- which these operations improve quality $250,000 per proposal over two years, chosocial function. To date, in-depth of life from the patient perspective. and four proposals per year are planned qualitative data from 84 patients from The objective of this project is to for funding in 2021. The Alliance various countries (United States, Cana- develop and validate a patient- strategic priorities currently include: da, Denmark and the Netherlands) has reported outcome measure specific been used to create preliminary scales for face vascularized composite tissue Addressing health disparities by for feminizing and masculinizing gen- candidates and recipients. To date, increasing accrual of minority and der-affirming procedures. The center the team has conducted a systematic vulnerable population members to is currently seeking feedback from a literature review to identify PROMs that Alliance research protocols, and by global team of experts and patients to are currently being used to measure assessing the impact of the Social establish content validity (i.e., compre- outcomes in this patient population Determinants of Health (including hensiveness, comprehensibility and develop a preliminary conceptual financial toxicity) on outcomes in and relevance) of the GENDER-Q scales, framework (manuscript in press). Alliance trials. followed by the launch of the GENDER-Q They have also performed in-depth field test at multiple sites across the qualitative and cognitive interviews with Expanding Alliance portfolio in globe in late fall 2021. The PROVE four postoperative patients. Qualitative implementation science (including Center is a full partner in this program interviews were conducted using a de-implementation). of research. semi-structured interview guide and cognitive interviews involved the review Developing methods to enhance Development of a condition-specific of existing scales from the FACE-Q awareness of and effective utilization patient-reported outcome measure Head and Neck Cancer and Craniofacial of Alliance data and banked for patients with chronic headaches. Modules teams, using the think-aloud biospecimens. Headaches impose a tremendous approach. Qualitative and cognitive burden on ones’ quality of life, including interviews will continue with pre- and Expanding Alliance capability to support physical and cognitive function. postoperative patients until saturation molecular, biomarker driven studies, Traditionally, treatment for headaches of concepts is achieved. including imaging as a biomarker. has involved preventative and abortive medications, opioids, injectables and Alliance for Clinical Developing and implementing a medical devices. More recently, surgical Trials in Oncology strategy to engage and support early techniques have evolved to decompress career investigators from all relevant the peripheral sensory nerves around Alliance continues to expand its disciplines, with particular emphasis the skull to improve the frequency, research portfolio, currently serving on researchers from underrepresented severity and duration of headaches. as the lead organization for 47 clinical minority groups. The team is developing a new patient- trials funded by the National Cancer 36

News Faculty News & Notes Paul Davidson, PhD, was elected the & Notes secretary of the American Society for Geoffrey Anderson, MD, MPH, was Metabolic and Bariatric Surgery (ASMBS) New Endowed Chairs elected to the editorial board of the Integrated Health Section. Journal of Surgical Research; was named Zara Cooper, MD, MSc co-lead for the Non-English-Speaking Christopher Ducko, MD, was elected Michele and Howard J. Kessler Trauma Survivors (NESTS) Pathway to the Medical Executive Committee at Distinguished Chair in Surgery and as part of the Mass General Brigham South Shore Hospital. Public Health United Against Racism initiative; and was recommissioned as a major in the U.S. Mark Fairweather, MD, was appointed Ali Salim, MD Air Force Reserves on a critical care air Student Advanced Elective director in the BWH Distinguished Chair in Surgery transport team. Brigham Department of Surgery. Stefan G. Tullius, MD, PhD Stanley Ashley, MD, was named a Joaquim Havens, MD, was a nominee Joseph E. Murray Distinguished Chair in dedicatee of the American College for the Excellence in Mentoring Award Transplant Surgery of Surgeons Owen H. Wangensteen from Harvard Medical School; and was Scientific Forum; and was appointed to an instructor at the Stratus Center for Faculty Promotions the American College of Surgeons Board Medical Simulation Update in Primary of Governors Diversity Pillar. Care Mass Casualty Simulation in Professor Tampa, FL. Steven Piantadosi, MD, PhD Thanh Barbie, MD, received an R01 grant from the National Institutes of Health Kamal Itani, MD, was awarded an Associate Professor for her work on optimizing therapeutic honorary fellowship from the Surgical Joaquim M. Havens, MD STING agonism in triple-negative breast Infection Society (SIS) and the SIS M. Blair Marshall, MD cancer; and received a Susan F. Smith Presidential Citation. James Yoo, MD Center for Women’s Cancers Innovation Grant for improving antigenicity in triple- Molly Jarman, PhD, MPH, was named Assistant Professor negative breast cancer. statistical editor of the Journal of Shailesh Agarwal, MD Surgical Research. Justin Broyles, MD Raphael Bueno, MD, became a member Carleton E. Corrales, MD of the Cancer Biomarkers Study Section Tsuyoshi Kaneko, MD, was appointed Tanujit Dey, PhD of the National Institutes of Health. associate chair of the Society of Ann Marie Egloff, PhD, MPH Thoracic Surgeons (STS) Workforce on Molly Jarman, PhD, MPH Nancy Cho, MD, was elected to the New Technology. Abraham Lebenthal, MD Association for Academic Surgery (AAS) Alice Maxfield, MD Program Committee; was elected to Olga Kantor, MD, MS, was appointed vice Christina Minami, MD, MFA, MS the American Association of Endocrine chair of the Society of Surgical Oncology George Molina, MD, MPH Surgeons (AAES) Education Committee; (SSO) Fellows & Young Attendings Stephanie Nitzschke, MD, MS and was elected to the Society of Asian Subcommittee. Namrata Patil, MD, MPH, MBBS Academic Surgeons (SAAS) Program Kavitha Ranganathan, MD Committee. Tari A. King, MD, was named a fellow Rosh Sethi, MD, MPH of the American Society of Clinical Thomas C. Tsai, MD, MPH Thomas E. Clancy, MD, was named Oncology (ASCO). Ashley Vernon, MD the inaugural Distinguished Scholar in Surgical Oncology at the Brigham. Sayeed K. Malek, MD, was appointed to serve on the Clinical Advisory Board of Zara Cooper, MD, MSc, was named the the New England Donor Services (NEDS); inaugural Michele and Howard J. Kessler and was named director of the Brigham Distinguished Chair in Surgery and Public transplant service line. Health at the Brigham; and received the Brigham Department of Surgery Richard Alice Z. Maxfield, MD, was appointed E. Wilson Teaching Award. associate program director of the Harvard Medical School/Mass Eye Antonio Coppolino, MD, was awarded and Ear/Mass General Brigham the Division of Thoracic and Cardiac Otolaryngology–Head & Neck Surgery Surgery 2021 F. Griffith Pearson Award Residency Program. for Excellence in Teaching. 37

Christina Minami, MD, MFA, MS, was infertility in female surgeons: Impact Scott Swanson, MD, was named co- awarded a Grant for Early Medical/ on surgeon burnout and attrition;” was editor of Sabiston & Spencer Surgery of Surgical Specialists’ Transition to the keynote speaker at the University of the Chest, 10th edition; was appointed Aging Research (GEMSSTAR) award Pittsburgh Physician Thrive Program editor of the Guest Edition of Current from the National Institute on Aging, Parenting and a Career in Medicine Challenges in Thoracic Surgery; and was “Locoregional treatment decision- Symposium; and was lead author of named co-chair of the AATS Thoracic making in older adults with early- the study, “Incidence of infertility and Clinical Practice Standards Committee. stage hormone receptor-positive pregnancy complications in U.S. female breast cancer.” surgeons,” which was published in Stefan G. Tullius, MD, PhD, was named JAMA Surgery. the Joseph E. Murray Distinguished Chair Elizabeth Mittendorf, MD, PhD, in Transplant Surgery at the Brigham; completed a Master in Healthcare Chandrajit P. Raut, MD, MSc, was the was appointed to the Medical Board Management at the Harvard T.H. Chan Kathy Maxwell Visiting Professor at Ohio of the National Kidney Registry; was School of Public Health; was named State University; and was elected to the appointed co-chair of the International treasurer elect for the American Society American Surgical Association (ASA). Society of Vascularized Composite of Clinical Oncology (ASCO); and was Allotransplantation (ISVCA) and awarded a grant from the Massachusetts Nakul Raykar, MD, MPH, was appointed the International Society of Uterus Life Sciences Center to support the fellowship director of the Harvard Transplantation (ISUTx) Congress, establishment of a digital pathology Medical School Program in Global 2023; was co-organizer of the 2021 effort within the Breast Oncology Surgery and Social Change; and International Society of Uterus Program at the Dana-Farber/Brigham was named interim vice chair for the Transplantation Congress; and was and Women’s Cancer Center. Advocacy Committee and institutional named chair of the 2021 International representative for the Association of Transplantation Congress Science George Molina, MD, MPH, received the Academic Global Surgery (AAGS). Committee. Minority Faculty Career Development Award from the Brigham and Women’s Robert Riviello, MD, MPH, was appointed Jiping Wang, MD, PhD, was awarded the Hospital Center for Diversity and professor of surgery and the inaugural Brigham Department of Surgery Donald Inclusion; and was awarded the KL2/ chair of the Department of Surgery at D. Matson Award. Catalyst Medical Research Investigator the University of Global Health Equity in Training (CMeRIT) award. Rwanda; was appointed deputy director Anna Weiss, MD, was appointed director of the Harvard Medical School Program of Breast Surgery at Dana-Farber/ Faina Nakhlis, MD, was awarded a Dana- in Global Surgery and Social Change; Brigham and Women’s Cancer Center Farber Cancer Institute Friend’s Grant and was awarded the American College in affiliation with South Shore Hospital; for her work on refining local-regional of Surgeons International Surgical was awarded a Dana-Farber Cancer therapy for inflammatory breast cancer. Volunteerism Award. Institute Friend’s Grant and a Susan F. Smith Center for Women’s Cancers Stephanie Nitzschke, MD, MS, was Ali Salim, MD, was named the inaugural Innovation Grant. appointed a member of the American BWH Distinguished Chair in Surgery; was Board of Surgery Entrustable appointed associate editor of the Journal Abby White, DO, was the course director Professional Activities (EPA) Revision of Trauma and Acute Care Surgery; for the Fredric G. Levin Lung Cancer Work Group. was named a member of the American Symposium. Association for the Surgery of Trauma Dennis P. Orgill, MD, PhD, was awarded Program Committee; and was appointed Resident/Fellow News & Notes the Research Achievement Award by to the American Surgical Association the American Association of Plastic Advisory Membership Committee. Sourav Bose, MD, MBA, MSc, PGY-3, Surgeons (AAPS). was the recipient of the Esther Tsai Doug Smink, MD, MPH, was appointed Sugg Award from the Society of Asian C. Keith Ozaki, MD, was appointed to associate medical director for surgery by Academic Surgeons (SAAS) for the the Society for Vascular Surgery (SVS) CRICO. highest scoring resident abstract, Strategic Board of Directors. “Fetal base editing ameliorates Desiree Steimer, MD, was a Thoracic cardiac pathology in a mouse model of Erika Rangel, MD, MS, was awarded Surgical Robotics Fellowship recipient mucopolysaccharidosis type I,” at the the Brigham and Women’s Hospital from the American Association for annual Academic Surgical Congress; Department of Surgery Robert T. Osteen Thoracic Surgery (AATS) Foundation. and was the recipient of the Joe Leigh Junior Fellowship award for the project Simpson Award for the Best Early Career titled, “Pregnancy complications and Investigator at the annual International 38

Conference on Prenatal Diagnosis and study, “Defining the natural history from the University of Michigan Therapy for his oral presentation “In and drivers of surgical referral of Undergraduate Research Opportunity utero genome editing restores cardiac pediatric umbilical hernias to reduce Program (UROP). function and improves survival in unnecessary surgery.” mucopolysaccharidosis type I.” Rowza Rumma, MD, PGY-5, was Frances Hu, MD, MSc, PGY-3, was the awarded the Johnson & Johnson James Etheridge, MD, PGY-2, was the recipient of an American College of Innovation Grant from Johnson & recipient of an American College of Surgeons Scientific Forum Excellence Johnson and Harvard Catalyst for her Surgeons Scientific Forum Excellence in in Research Award for her abstract, project, “Clinical predictive modeling Research Award. “Surgeon-reported barriers and of anastomotic leaks using hyper facilitators to Adoption of standards for spectral imaging.” Sameer Hirji, MD, PGY-3, received the goal-concordant care in patients with Harvard Affiliated Emergency Medicine advanced cancer.” Bixiao Zhao, MD, PhD, PGY-3, was Residency (HAEMR) 2021 General awarded the Best Basic Science Paper Surgery Consult Resident of the Year Thinzar Helmi Lwin, MD, MS, PGY-7, award at the American Association Award; was awarded the Department was awarded the Society of Surgical of Endocrine Surgeons (AAES) of Surgery Class of 1963 Scholar Oncology (SSO) Resident/Fellow Essay 2021 Annual Meeting for his work Award; and was awarded the American Contest Best Basic Science Research entitled, “Glycolytic inhibition with College of Cardiology Massachusetts Paper Award for the study, “Rapid tumor 3-bromopyruvate suppresses tumor Chapter Research Award for his work on, labeling kinetics with a site-specific near- growth and improves survival in a “Outcomes of surgical explantation of infrared anti-CEA nanobody in a patient- murine model of anaplastic thyroid TAVR – A population-based, nationally- derived mouse model of colon cancer.” cancer;” and received the Podium representative analysis.” Prize at the New England Surgical Pooja Neiman, MD, MPA, PGY-3, Society (NESS) 2021 Annual Meeting Katherine He, MD, MS, PGY-3, was won a 2020 American Association for the for his presentation, “Inhibition of the recipient of a National Institutes of Surgery of Trauma (AAST) Resident lactate export suppresses growth Health (NIH) National Research Service Research Scholarship; and received the and metabolism of anaplastic Award (NRSA) F32 fellowship for the 2020-2021 Outstanding Mentor Award thyroid cancer.” Top Doctors Boston Magazine’s 2021 “Top Doctors” issue recognizes 41 Department of Surgery faculty members this year. Congratulations to the following providers for being recognized as the best in their respective fields: Colon and Rectal Surgery Gerard Doherty, MD Steven Mentzer, MD The following board- Atul Gawande, MD, MPH Scott Swanson, MD certified Brigham Oral Ronald Bleday, MD Pardon Kenney, MD, MMSc Jon Wee, MD Medicine specialists were Joel Goldberg, MD, MPH Tari King, MD Daniel Wiener, MD included in Boston Sayeed Malek, MD Magazine’s “Top Dentists Otolaryngology Faina Nakhlis, MD Urology 2021” list: Chandrajit Raut, MD, MSc Herve Y. Sroussi, DMD, PhD Donald Annino, MD, DMD Esther Rhei, MD Steven Chang, MD, MS Nathaniel S. Treister, DMD, DMSc Scott Shikora, MD Adam Kibel, MD Sook-Bin Woo, DMD, MMSc Plastic Surgery Douglas Smink, MD, MPH Michael Malone, MD Ali Tavakkoli, MD Michael O’Leary, MD, MPH 39 Matthew Carty, MD Ashley Vernon, MD Graeme Steele, MD Yoon Chun, MD Dennis Orgill, MD, PhD Thoracic and Cardiac Vascular Surgery Andrea Pusic, MD Surgery Christian Sampson, MD Michael Belkin, MD Simon Talbot, MD Raphael Bueno, MD Edwin Gravereaux, MD Christopher Ducko, MD Matthew Menard, MD Surgery M. Blair Marshall, MD Charles Ozaki, MD Hari Mallidi, MD Stanley Ashley, MD Monica Bertagnolli, MD Thomas Clancy, MD

Development With our donor’s support, the Brigham Department of Surgery is able to deliver the highest quality patient care, pursue the most innovative and promising medical research and train the brightest medical minds to become the next generation of health care leaders. Cogan and Cornille give in Cogan and Cornille received pledged $450,000 to continue their memory of friendship and love excellent medical care from their support of the Pamela and Nick doctors at the Brigham for many Gelsomini Breast Surgical Oncology With a connection spanning seven years. And for Cornille, the Brigham Fellowship. Directed by Tari King, MD, decades, the late John “Jack” Cogan holds special meaning. Toward the the fellowship has supported several and the late John Mannick, MD, proved end of Cogan’s life, the therapeutic trainees since 2018, two of whom some friendships are timeless. They approaches of the Osher Center for finished and stayed on as full-time met as young men at Harvard in 1945, Integrative Medicine helped improve faculty in the Dana-Farber/Brigham after Cogan served in World War II, his mobility, which was vital to him as and Women’s Cancer Center. and formed a bond that would outlast an avid runner. To honor her husband’s long-distance moves, raising families memory and recognize those benefits, Gelsomini looks forward to and building successful careers. Cornille contributed $125,000 to the seeing more fellows rise through the Cogan became an esteemed lawyer center to support patients’ well-being program and bring their expertise to and leader in the financial services and advance therapies emphasizing communities in need, especially rural industry. Dr. Mannick became a the mind-body connection. or remote areas where specialty care pioneering vascular surgeon and may be scarce. She also marvels at surgeon-in-chief at the Brigham. “Every day he could, Jack would the highly targeted, minimally invasive run along the Charles River,” Cornille treatments being honed and perfected “Jack and John were powerhouses said. “In the end, he couldn’t run like today by Brigham surgeons. in their lives,” Mary Cornille, Cogan’s he did before, but learning Tai Chi and wife, said. “Jack had a remarkable receiving manipulative therapy at the “I’ve been inspired watching the career and was involved in many civic Osher Center noticeably improved his fellows come into their own and and charitable organizations. And John movement and provided relief.” flourish as surgeons and scientists,” was a wonderful doctor, leader in his Gelsomini said. “It’s so promising to field, and dear friend. They inspired Cornille hopes her gift will enable the know what care teams can do now each other throughout their lives.” center to increase medical education and to envision where the next five and awareness of integrative medicine. years will bring us. All of the steps When Dr. Mannick died in late 2019, “If this means more people could be being taken and all of the people who Cogan was facing his own serious helped the way Jack was, that would will survive because of their work—it’s health challenges. Nonetheless, be truly wonderful,” she said. wonderful to witness change.” he was determined to endow a professorship to preserve his friend’s Gelsominis renew commitment Caneparis provide critical legacy. Though Cogan didn’t see to breast cancer fellowship resources for lung patients it come to fruition, he ensured his wishes would be fulfilled through a $4 For the past 10 years, as long This past year, David and Diane million bequest from his estate, which as she has been a breast cancer Canepari continued their philanthropy established the John Anthony Mannick survivor, Pamela Gelsomini has been to the Brigham’s Lung Center through a Professorship of Surgery at Harvard proud to be part of the Brigham’s commitment of more than $800,000 to Medical School. The incumbent will efforts to transform cancer care. An support new technologies that directly be a professor or associate professor entrepreneur and avid cook and food enhance patient care. focused on vascular or immunology- blogger, she credits the Brigham for related surgery at the Brigham. restoring her health and generously supports the hospital to help other patients facing a breast cancer diagnosis. Gelsomini stays connected with her care providers and actively participates on the hospital’s Cancer Research and Care Advisory Board, which keeps her informed of the latest science and treatment advances. She and her husband, Nick, recently 40

“We’re excited this technology is opening up new possibilities and know Dr. Bueno and his team will continue innovating and improving care.” The Caneparis’ support has helped Goldman-Blotner family fuels he and his wife, Nancy Adams, did not the Brigham acquire a specialized mesothelioma cancer research hesitate to seek medical help. After portable chest CT scanner, which Schoen was rushed to the Brigham by enables critical imaging in the Following Mark Blotner’s diagnosis ambulance, they learned he needed operating room or at the bedside of of mesothelioma, a rare lung cancer emergency surgery to mend his aorta, acutely ill patients. In addition, a new often caused by asbestos exposure, he the main artery that pumps blood from state-of-the art robotic device will and his wife, Cindy, have been inspired the heart to the rest of the body. aid bronchoscopies to identify and by his surgeon Raphael Bueno, MD, eliminate small peripheral nodules in chief of the Division of Thoracic and “We look at May 19, 2020, as my new the lungs. Cardiac Surgery at the Brigham. first birthday,” Schoen, who recovered with excellent results after a seven- “David and Diane are making an Over the last several years, the hour procedure, said. “Surviving the incredible impact on the care we can Goldman-Blotner family and their surgery, and in such good health, is deliver to lung patients,” Raphael friends have raised more than a miracle to me,” he added, noting Bueno, MD, chief of the Division $500,000 to bolster Dr. Bueno’s the high mortality rate for an aortic of Thoracic and Cardiac Surgery, investigations, including his work dissection if not tended to quickly. co-director of the Lung Center and to test drugs in clinical trials and to “Without a doubt, Nancy and I wanted David’s physician, said. “The mobile CT explore harnessing the immune system to make a meaningful gift to the scanner will be a game-changer, since to fight mesothelioma. In particular, hospital as a way to say thank you.” it allows us to capture images in the Cindy’s father, Allan Goldman, has operating room and for immobilized continued his generosity with multiple The couple committed $1 million to patients, while the robotic device substantial gifts. the Brigham for research to improve enhances and refines bronchoscopies. the understanding of vascular and We’re so grateful for David and Diane’s “My family and I are committed cardiovascular disease. Half their gift generosity.” to supporting Dr. Bueno’s research fuels a vascular disease biobank and and are very encouraged by the biospecimen collection, under the The Caneparis’ giving builds on revolutionary advances he and his direction of Gerard Doherty, MD, chair their recent contributions to the team are making,” Goldman said. of the Department of Surgery, and hospital’s COVID-19 response— which half supports women’s cardiovascular allowed the Brigham to secure ECMO Lifesaving experience spurs disease initiatives under the leadership machines that provide lifesaving Schoen and Adams to give of Hadine Joffe, MD, MSc, executive breathing support to patients in $1 million director of the Connors Center for critical care. Diane and David, an Women’s Health and Gender Biology. active and committed member of In May 2020, 62-year-old Scott the hospital’s Lung Center Advisory Schoen was exercising at home when “We’re grateful for Scott and Nancy’s Board, have a history of supporting he started experiencing chest pain and generosity and flexibility to support the center, including gifts for research, dizziness. Though Massachusetts had areas we think will be most effective in a comprehensive lung screening a surge in COVID-19 cases at that time, developing new knowledge of disease,” program and the thoracic surgery Dr. Doherty said. fellowship program. “With Scott as a member of the “I’m grateful that I’ve received Mass General Brigham Board of excellent care from Dr. Bueno and want to continue supporting his work in helping other patients with lung conditions, especially those facing COVID-19,” David said. 41

Trustees and Nancy as a member of treatment. technologies and retain talented the Women’s Health Advisory Board at The gift is also fueling surgeons. This funding enables more the Brigham, they are both tuned into surgeons to become certified in the needs for research to help im- cardiovascular research focused advanced robotic surgery systems, prove diagnosis and treatment,” on atherosclerosis and other while also paving the way for more Dr. Joffe added. arterial diseases and supporting residents to continue their careers at the Brigham’s plans to renovate the hospital. The Crowleys” gift also For Schoen, the ability to return the Emergency Department. With allows surgeons at all levels to pursue to full activity one month after these enhancements, the hospital research and develop programs that surgery, including golfing, with no will increase its capacity to offer make surgery safer, more patient- complications or lingering pain, is the more specialized, streamlined and centered and accessible. best outcome he could have imagined. comfortable emergency care for patients who turn to the Brigham. Dr. Doherty says these are just a “It’s a new lease on life. We feel few ways the Crowleys’ giving helps to blessed to give back to the talented Crowley family empowers stellar improve surgical care for patients at vascular experts at the Brigham,” surgical leadership the Brigham and beyond. he said. When Andy and Janice Crowley “I am honored to hold the Crowley Gift benefits cancer research established the Crowley Family Family Distinguished Chair,” Dr. and Emergency Department Distinguished Chair in the Department Doherty said. “The Crowleys’ continued expansion of Surgery in 2013, they sought to generosity has been invaluable, honor the excellent care their family especially through the heightened To keep moving medicine toward received at the Brigham. challenges of the COVID-19 pandemic. individualized approaches, it takes Their support has helped us plan for investment in bold research and The chair has empowered Gerard the long-term and launch countless innovative health care delivery ideas. Doherty, MD, surgeon-in-chief, to careers. That should give us all hope strengthen the hospital’s world-class for the future of medicine.” Recognizing these needs, two surgical leadership and support his longtime supporters of the Brigham team of experts at every stage of Bulens family invests in cardiac anonymously contributed $150,000 to their careers. The Crowleys recently surgery fellows research for breast cancer and heart deepened their commitment to the disease, as well as the expansion chair with a $300,000 gift, which will Hoda Javadikasgari, MD, the newest and improvement of emergency further Dr. Doherty’s efforts to shape Bulens Family Fellow in Cardiac department facilities. the future of surgical care. Surgery, is passionate about using computer science to develop new This generous gift builds on “Our family has leaned on the cardiac surgical techniques and the supporters’ history of aiding Brigham for our care and the hospital enhance patients’ health. investigators in the Division of Breast has always been there for us,” Andy Surgery, who are developing more said. “We’re proud to support the chair Through this advanced fellowship, personalized approaches for breast so the Brigham maintains its surgical she has an opportunity to conduct cancer screening, prevention and excellence.” research that improves conventional cardiac surgery techniques and The chair provides resources that develops new, minimally invasive are especially critical as Dr. Doherty approaches to heart valve repair works to expand training in new and replacement. 42

Lynne and Donald Bulens, whose him a star to countless patients and in theSupport the Work giving launched the fellowship in 2017, families. His exceptional caregiving of the Department recently made a generous new gift to made a strong impression on members of Surgery sustain the program. of the MacDonald family, who recently gave $250,000 to the Brigham Each year, thousands of people “We’re tremendously thankful for through the Frank R. and Elizabeth entrust the Department of Surgery the support of the Bulens family,” Simoni Foundation, a philanthropic at Brigham and Women’s Hospital Tsuyoshi Kaneko, MD, who is over- organization that supports education, to provide them with excellent seeing Dr. Javadikasgari’s work, health care and other needs in the medical care. Many people turn to said. “Because of their commitment, Greater Boston community. us because of our long history of the next generation of talented medical firsts and reputation for researchers is pursuing pioneering With this gift, the Simoni Foundation attracting the finest surgical trainees work in cardiovascular surgery.” seeks to honor Dr. Clancy by and surgeons in the country. One of establishing a fund to strengthen the reasons we have been able to Dr. Javadikasgari envisions outcomes research for pancreatic, build such a strong program—and to improved surgery and outcomes biliary and liver cancers—one of Dr. establish new standards of surgical for patients with severe mitral Clancy’s greatest priorities. This type care—is because of philanthropic valve disease who cannot undergo of research examines patients’ results contributions from people like you. conventional surgery. Doctors after surgeries or other interventions can conduct a minimally invasive to determine which approaches work Gifts from our alumni, patients and procedure called MitraClip to implant best and which can be improved. friends help us to train our staff in the a device and help the mitral valve latest surgical techniques, to make close more completely, but it requires “We admire Dr. Clancy’s passion for advances in surgery through research careful planning to ensure correct improving treatment and quality of life and to achieve the best possible placement. Through the fellowship, Dr. for patients,” Matthew MacDonald, outcomes for patients. When you Javadikasgari plans to develop a new president of the Simoni Foundation, make a gift to the Department of mathematical model to predict optimal said. “We are pleased to provide Surgery, you enable our medical MitraClip placement in patients. flexible resources for him to lead and team to provide the most advanced pursue research that can change the care and make a difference for every Raphael Bueno, MD, chief of the course of these cancers.” patient and family member we see. Division of Thoracic and Cardiac Surgery, sees the Bulens’ philanthropy Dr. Clancy is thankful to the family For more information if you are as crucial in fulfilling the division’s for helping his team uncover insights interested in making a gift to the goals for training and future care. about these diseases and to ultimately Department of Surgery at Brigham steer the field toward more targeted, and Women’s Hospital, or to a “Our fellows are tackling some of successful treatments. “The Simoni specific physician or scientist within the field’s most vexing challenges,” Foundation’s generous support is the department, please contact he said. “They are paving the way for critical to accelerating promising Susan Andrews, assistant vice new surgical approaches that will help investigations. This work will inform president of the Development Office, patients in Boston and beyond.” and guide care for patients today and at 617.424.4349 or [email protected] Frank R. and Elizabeth Simoni Foundation advances cancer care Thomas Clancy, MD, is one of the top surgical oncologists specializing in pancreatic, biliary and liver cancers. As a researcher and educator, Dr. Clancy is at the forefront of progress for treating these serious and often life-threatening cancers, which can develop undetected to advanced stages when treatment becomes less successful. Also known for his compassion and attentiveness as a surgeon, Dr. Clancy possesses qualities that have made 43

Leadership Sarah Broughton Herd Director, Surgery Education Office Gerard M. Doherty, MD Moseley Professor of Surgery, Harvard Medical School Matthew S. Sandler, MBA Surgeon-in-Chief, Brigham and Women’s Hospital & Senior Director of Finance Dana-Farber Cancer Institute Crowley Family Distinguished Chair, Department of Surgery, David A. Steger, MS Brigham and Women’s Hospital Director of Communications C. Keith Ozaki, MD Victoria (Tori) Wilmarth, MBA Executive Vice Chair, Department of Surgery, Brigham and Director of Network Strategy Women’s Hospital John A. Mannick Professor of Surgery, Brigham and Women’s Division Administrators Hospital Professor of Surgery, Harvard Medical School Paul Buckley Breast Surgery Douglas S. Smink, MD, MPH Chief of Surgery, Brigham and Women’s Faulkner Hospital Jennifer Fanning Vice Chair for Education General and Gastrointestinal Surgery Ronald Bleday, MD Nathan J. Burke, MBA Vice Chair for Quality and Patient Safety Oral Medicine Tari A. King, MD Michelle Swoboda, MHA Vice Chair for Multidisciplinary Oncology Otolaryngology—Head and Neck Surgery Elizabeth Mittendorf, MD, PhD Shannon Weiss, RN, MBA Vice Chair for Research Plastic and Reconstructive Surgery Louis L. Nguyen, MD, MPH, MBA Jenna Khalili, MBA Vice Chair for Digital Health Systems Surgical Oncology Malcolm K. Robinson, MD Philip Girard, MS Vice Chair for Clinical Operations Thoracic and Cardiac Surgery Ali Salim, MD Keila Jackson, MHA Vice Chair for Surgical Critical Care Transplant Surgery Jennifer Shin, MD, SM Susannah Rudel, MPH, MBA Vice Chair for Faculty Development Trauma, Burn and Surgical Critical Care Philip D. Roberts, MBA Sandra Doolan, MBA Executive Administrator Urology Suzanna Clark, MHA Lorraine T. Levitsky Senior Director of Operations Vascular and Endovascular Surgery Gina Tonogbanua Custer, MA, CRA Administrative Director of Research Department of Surgery • 75 Francis Street • Tower 1 – Room 110 • Boston, MA 02115 Contact Us • [email protected] • 617.732.8181 Follow Us • twitter.com/brighamsurgery Brigham Surgery Alumni Stay in Touch! The Brigham Surgery Alumni Group consists of graduates of Brigham and Women’s Hospital surgery residency and fellowship programs and former Department of Surgery faculty members. If you would like to join the Brigham Surgery Alumni Group and receive news and updates from the Department of Surgery, please visit: brighamsurgerynews.com/alumni/ or email us at: [email protected]