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• Our CYWH nutrition team has Our nutrition team alone received over continued to provide reassuring 25 nutrition based support to our visitors, despite the global pandemic “Ask Us” • o In addition to providing questions over the last year, answering nutritional support and guidance through our “Ask Us” many of them. feature, our dietitians created new health guides and blogs Our team hosted on the following topics: Healthy Food Swaps, Intuitive Eating over 24 with Allergies, Pre-workout Supplement (How Safe Is It?), moderated virtual support Wear a Mask While Working groups to young women Out (How Safe Is it?), and diagnosed with PCOS, Weight Stigma endometriosis, and • Our CYWH nutrition team MRKH (and MRKH embarked on changing a beloved parents) CYWH favorite, our teen friendly cookbook! They revised 15 of the original recipes to be faster, easier to create — and healthier! — than before • The CYWH developed a new resource for transgender youth. In collaboration with Dr. Grimstad and Dr. Emile Redwood, our team created Contraception for the Transgender Person Division Awards/Honors/Promotions Marc R. Laufer, MD • America’s Top Doctors, Castle Connolly Medical LTD • Who’s Who in America, Marquis Who’s Who LLC • Patients’ Choice Award, Vitals Patients’ Choice • Who’s Who in the World, Marquis Who’s Who LLC • “Best Doctors in Boston,” Boston Magazine • 2022 Mentor Award, The American College of Obstetricians and Gynecologists Frances Grimstad, MD • Boston Children’s Hospital Academy Healthcare Professional Education Grant, Boston Children’s Hospital • Boston Children’s Hospital Prism Award Nominee, Boston Children’s Hospital Jessica Shim, MD • 2021 Best in Care Award - nominee • 2021 BCH Teaching Certificate Member 50 Department of Obstetrics and Gynecology

Our Voices Boston Children’s Hospital Creates New Complex Anomalies Clinic We developed Boston Children’s Complex Anomalies We serve this patient population outside of clinic Clinic to streamline the experience of our young through our partnership with the Center for Young patients with rare anomalies, particularly MRKH Women’s Health with health guides specific to (Mayer-Rokitansky-Küster-Hauser Syndrome), and to MRKH for teens, parents, and significant others. consolidate the learning experience of our trainees. For the past 16 years, we have hosted an annual The clinic has seamlessly integrated fellow and junior MRKH conference for teens and their parents. attending learners and incorporated nursing and social The main goal of this conference is to provide work staff to fully promote and contribute to the unmatched knowledge and support for teens emotional and mental well-being of our patients. The diagnosed with MRKH. The value of this conference clinic provides a safe space for patients to meet each is evident when reviewing the testimonials from other. From check-in to check-out, our staff strives to our most recent conference, which speak to its promote an inclusive and welcoming environment, so impact. These heartwarming expressions motivate these patients can be educated about their anatomy and solidify our ongoing commitment. and feel empowered as individuals and as a group. “This is my first time attending this conference, and I found it a safe space to listen and ask questions. I am so glad that we were able to attend. Thanks so much to the organizers and speakers; I was feeling alone and lost. But having found these resources, especially connecting with others, has helped me find a sense of calm. Unfortunately, we don’t have the same resources in our country as [of] yet.” – Teen girl “Good to hear about the future for young women with MRKH — medical breakthroughs, family planning options, awareness. Thank you.” – Parent of a teen “I had to force my 14-year-old to attend. It was the best thing. She started participating in the breakout group, and that is a great step. I truly appreciate this.” – Parent of a teen “Thank you SO MUCH for having this virtual conference, and both my mom and I found it extremely helpful!” – Teen girl “Nurse Emily, I don’t know if you’ll get this, but I didn’t get the chance to say thank you before the chat ended. I hope you know how much you mean to these young girls with MRKH and parents like us. You’re an angel...thank you! Please send our best to your entire team...you are all so appreciated!” – Email from a father of a patient diagnosed with MRKH “Young Women’s Health [is a] website published by Boston Children’s Hospital that provide teenagers with carefully researched health information to give them the tools to understand their health and development.” – An excerpt published in the New York Times naming the Center for Young Women’s Health as a reliable source for sexual education resources Clinical Divisions 51

Private Staff Division Members James Greenberg, MD Rafik Mansour, MD Ashley Ackerman, MD Gary Gross, MD Evelyn Marsh, MD Cecilia Bahamon, MD Yvette Groszmann, MD Julie Miner, MD Beryl Benacerraf, MD* Harneet Gurjal, MD Hannah Parker, MD Bryann Bromley, MD Vicki Heller, MD (Honorary) Charissa Pettyjohn, MD Marikim Bunnell, MD Joan Hier, MD Beatrice Pitcher, MD (Honorary) Carolyn Cline, MD Anila Jha, MD Thomas Shipp, MD Tom Connolly, MD Jeffrey Katz, MD Shannon Smith, MD Laurent Delli-Bovi, MD Paula Kolbas, MD Sivan Vainer, MD Derna Demaggio, MD (Honorary) Lisa Lampert, MD Alice Vincent, MD Lauren Ditrio, MD Sarah Lassey, MD Kathryn Wang, MD Sandy Falk, MD Randi Leigh, MD Dale Weldon, MD Jerome Federschneider, MD Annie Liau, MD Tracy Zinner, MD Barbara Frank, MD Taryn Lieberman, MD Mission The Private Staff of the Department of Obstetrics and Gynecology at the Brigham and Women’s Hospital is committed to the highest standard of clinical care. We provide culturally sensitive and complete care to all our patients. We are the largest group of private physicians affiliated with any department at the BWH. Our practices include Brigham Faulkner OB/GYN, Brookline Village OB/GYN, Boston Healthcare for Women, Commonwealth OB/GYN, and New England OB/GYN Associates. We work in concert with the full-time faculty in the Department of OB/GYN to provide complete care for women from early adulthood through post menopause. We practice in a way that is personal, individualized, and comprehensive. The Private Staff is current with the latest advances in our specialty and affords our patients access to all the advanced care offered at Brigham and Women’s Hospital. *Dr. Benacerraf passed away on October 1, 2022. We thank her for her dedication to our department. 52 Department of Obstetrics and Gynecology

Our Voices The members of the Private Staff remain strong The Private Staff has been at the forefront of advocates for women’s health and reproductive rights. offering outpatient fetal monitoring for high-risk We support women’s choices for birth control and pregnancies. These initiatives all improve access management of their health and pregnancies. The and convenience for our patients while maintaining Private Staff offers both medical and surgical the high level of care they deserve. management for pregnancy loss. We were actively involved in the initiation of the project for outpatient cervical ripening to improve patient experience and alleviate the overcrowding of the hospital facilities. Clinical Divisions 53

Reproductive Endocrinology and Infertility Mark D. Hornstein, MD, Director Professor, Harvard Medical School Division Members Fellows Lisa Henaghan, RN (hybrid) Physicians Jenny S. George, MD Amy Mancini, RN Elizabeth S. Ginsburg, MD Margeaux C. Oliva, MD Vanessa Marshall, RN (per diem) Medical Director Professor, Harvard Medical School Anna C. Vanderhoff, MD Amy McLaughlin, RN Zachary W. Walker, MD Kathleen Nelson, RN (per diem) Serene S. Srouji, MD Medical Director Embryologists Danielle Provost, RN (per diem) Assistant Professor, Harvard Katherine Go, PhD, Interim Director Beth Staunton, RN (per diem) Medical School Berhan Bogale, BS Amanda Sullivan, RN Tina Capello, BS Raegan Thomas, RN (float) Raymond M. Anchan, MD, PhD Assistant Professor, Harvard Kerry Kelleher, BS Angeline Mejia, Surgical Tech Medical School Courtney McAulay, BS Jennifer Muller, Surgical Tech Rachel K. Ashby, MD Assistant Professor, Harvard Jay Patel, MS, TS Alyssa Payne, Surgical Tech Medical School Wana Popal, BS Nurses, Center for Infertility and Robert L. Barbieri, MD Erin Plimpton, BS Reproductive Surgery Kate Macy Ladd Distinguished Lydia Shi, MD Barbara Appel, RN (per diem) Professor, Harvard Medical School Cassandra Thomas, BS Ellen Cotto, RN Ann Wolkovich, BS Shannon Lynch, RN Janis H. Fox, MD Liben Zhu, MD Kathleen Charbonnier, RN Assistant Professor, Harvard Medical School Epidemiologist Najmah Freeman, RN Antonio R. Gargiulo, MD Andrea Lanes, MSc, PhD Nanci Hanron, RN Associate Professor, Harvard Medical School Physician’s Assistant Nancy Harrington, RN (per diem) Allison Ruhe, PA-C Lisa Henaghan, RN (hybrid) Kimberly W. Keefe Smith, MD Patricia Kennedy, RN Instructor, Harvard Medical School Nurses, Center for Assisted Karen Londergan, RN Reproductive Technologies Kathleen Nelson, RN (per diem) Marc R. Laufer, MD Mary T. Baracewicz, RN (per diem) Pamela Whitney, RN Professor, Harvard Medical School Heather Berrien, RN (float) Brian W. Walsh, MD Deirdre Egan, RN (per diem) Charlotte Heroux, Practice Manager Associate Professor, Harvard Medical School Stacie Dugan, RN Administrative Support Elena H. Yanushpolsky, MD Alexandra Fremont-Smith, RN (per diem) Denise Galotti, Sr. Administrative Assistant Professor, Harvard Rita Hatzis, RN (per diem) Medical School Assistant 54 Department of Obstetrics and Gynecology

Mission The Division is a dedicated team of academic physicians, embryologists, nurses, social workers, physician assistants, secretaries, and other administrative personnel whose core mission is helping patients build healthy families in a fulfilling work environment, conducive to innovative research and teaching. Quality patient care is our central mission and patient satisfaction our number one priority. We seek to treat all patients with cultural sensitivity, respect, and equity. Accomplishments in AY 21/22 Age of woman at Oocyte retrieval <35y 35-37y 38-40y 41-42y >42y • Successfully transitioned to All Fresh Cycles 428 305 243 133 63 virtual care # Starts 420 296 234 132 60 # Retrievals • Matched Margeaux Oliva, MD # Transfers 143 93 97 53 33 # Ongoing pregnancies (Icahn School of Medicine at Mt. % Ongoing pregnancies/Transfer 69 27 29 9 3 Sinai) to our fellowship program % Elective Single Embryo Transfers* % Sacs/Embryos Transferred 48.3 29.0 29.9 17.0 9.1 Cycle starts: 07/01/21 - 03/31/22. Data pulled is 7/19/22. Data includes autologous, donor and gestational carrier All Frozen Embryo Transfer Cycles 78.1 45 22.8 2.2 4.0 cycles. 28 fresh cycles were cancelled and 1 did not have a documented age. 6 fresh cycles are missing a # Starts 45.0 27.3 21.1 12.4 5.4 result. All have a documented age. 43 frozen cycles # Transfers were cancelled. 42 without a documented age. 2 frozen # Ongoing pregnancies 458 237 139 36 9 cycles are missing a result. 1 with a documented age. % Ongoing/Transfer % Single Embryo Transfers** 451 237 138 36 8 * % Elective single embryo transfer is defined as the % Sacs/Embryos Transferred transfer of 1 embryo when more than 1 embryo was 243 124 65 14 5 available to transfer. 53.9 52.3 47.1 38.9 62.5 ** % Single embryo transfer is defined as the transfer of 1 embryo, regardless of the number of embryos 92.6 84.8 76.3 63.9 33.3 available to transfer. 57.7 52.4 45.1 35.6 35.0 Fresh cycles include fresh cycle starts and cycles that are fresh cycles with the addition of a CET. Division Awards/Honors/Promotions Kimberly Keefe Smith, MD • Recipient of the Resident Teaching Award in Reproductive Endocrinology and Infertility as selected by the 2nd Year Residents in 2022 • Recipient of the 26th Annual Eleanor and Miles Shore Faculty Development Award for her project, “Premature Ovarian Insufficiency: Cause and Effect” Anna E. Vanderhoff, MD • Recipient of the Resident Teaching Award in Reproductive Endocrinology and Infertility as selected by the 2nd Year Residents in 2022 Zachary W. Walker, MD • Recipient of the American Society for Reproductive Medicine Diversity Research Grant and will support his continued research on male infertility Clinical Divisions 55

Our Voices Two patient journeys highlight the importance of reproductive choice Women’s health and reproductive rights have always been central to the Division of Reproductive Endocrinology and Infertility. The Center for Infertility and Reproductive Surgery (CIRS) faculty and staff firmly believe that it is the right of each individual or couple, regardless of marital status, sexual orientation, or gender identity, to build the family they wish in the manner they wish. It is our mission to help make that possible using the best available scientific, clinical, diagnostic, and therapeutic skills with an empathic and evidence-based approach. We would like to highlight the reproductive journey of two exceptional individuals who have through their own perseverance and effort, with the assistance of CIRS faculty and staff, built their family in ways not possible only a decade ago. Priya Lal is a Professor of History at Boston College. I was 33 years old when I froze my eggs. I returned to This is her story. Dr. Gargiulo four years later in 2018, recently married and ready to try for a first pregnancy. At that point, I “In the fall of 2012, at age 31, I was surgically also knew that regardless of my ovarian function, I diagnosed with stage four endometriosis at Yale New could not get pregnant naturally because my fallopian Haven Hospital after developing a large cyst on my left tubes were scarred shut by my endometriosis. My ovary. I had recently finished a PhD and just started my husband and I decided to try a fresh IVF cycle to academic career, but I had always known that I wanted save the frozen eggs for a second child. In the cycle, to have children and was looking forward to starting I discovered that my body’s ability to produce mature a family in the future. In one sense, the endometriosis eggs had already declined considerably from just diagnosis was a relief because it explained the pelvic a few years earlier, but the cycle was nonetheless pain and other symptoms that I had suffered from for successful. I had my son late that year. Once my over a decade. [However], the diagnosis also terrified son was born, it was wonderful to be able to focus me because I knew that it threatened my ability to on raising him and not feel rushed into attempting become a mother. I was overcome with panic at the another pregnancy right away; my frozen eggs gave idea that my body had irreversibly failed me. After the me that freedom. Earlier this year, my husband and I surgery, my reproductive endocrinologist at Yale put returned to pursue another IVF cycle using the eggs I me on oral contraceptive therapy and mentioned that had frozen so many years earlier. I am now 41 years I might consider freezing my eggs if I wasn’t ready to old and nine weeks pregnant from one of those eggs. attempt a pregnancy in the near future. It was the first I had heard of egg freezing, and I was initially wary of Becoming a mother has been the the idea. In the next couple of years, I learned more absolute highlight of my life, and about the practice as it became more common. By I am so grateful to have had doctors 2014, when I had moved to Boston for a new job, I was who were not content to allow me ready to explore the possibility of freezing my eggs. to become a passive victim of my My first conversation with Dr. Gargiulo convinced endometriosis. I hope other women me that I wanted to proceed. He explained the data like me have the same opportunities about egg freezing clearly and affirmed that I was and that fertility preservation comes making a wise decision. It was especially meaningful to be seen as a standard form of that he talked about fertility preservation as if it was medical care for those who need a form of medical care like any other, rather than a or want it.” frivolous lifestyle choice or an unnatural technological intervention as some public discourse suggested. I went ahead with three cycles of egg freezing, and while it was a strange experience, I ultimately felt it to be a liberating one: it released me from the fear of my endometriosis, and it gave me confidence in my ability to become a mother when I was ready. 56 Department of Obstetrics and Gynecology

Melissa “Lissy” and Evan Rau are both high school recreate our dreams of having a family. Lissy underwent teachers. This is their story as told by them. a cycle of IVF and had embryos frozen in 2013. “My husband, Evan, and I are both from big families All of this occurred while the COVID-19 Pandemic and dreamed of having our own family. I was an “older” was going on, so this meant Lissy needed to attend 37-year-old bride that wanted to start trying for a treatments alone and keep loved ones at a distance. [I] family right after our wedding. A year later, we were needed to be Lissy’s primary caretaker. The hardest part unfortunately still trying. At that point, we decided of the cancer diagnosis is that Lissy could no longer to reach out for infertility help. We were gratefully become pregnant because the cancer was hormonal. connected to Dr. Mark Hornstein, Director of It was so hard to lose our baby and then [to] so quickly Reproductive Endocrinology. His calm, compassionate learn we could no longer become pregnant was demeanor and layman way of explaining things really devastating. We began exploring surrogacy with put us at ease and installed hope. After many fertility family members being gestational carriers for us. tests, we learned that we had unexplainable infertility. Selflessly, we had my cousin’s wife, Jillian Burke, We began our infertility journey. After a few cycles of and cousin, Erin Melchiorri, give us the best gift of IUIs and IVF, we became pregnant with our first child. volunteering to be surrogates for us. On our first transfer, Jillian became pregnant with a little girl due on On September 20, 2019, our daughter Evalyn “Evie” Anne August 16, 2021. It was so exciting, but the experience Rau was born. Evie had a giggle that was contagious, was strange. Due to the pandemic, [we] were not a face expression for every occasion, [and] a smile that allowed to attend any of the doctor’s appointments or lit up the room. Our dreams were coming true. Tragically ultrasounds. On April 29, 2021, Jillian prematurely went on February 10, 2020, while family was caring for Evie, into labor and delivered our daughter, Marinna Jillian she unexpectedly passed away of SIDS. We were Rau, at 24 weeks. Marinna spent her first 161 days heartbroken. The little healthy girl we so dearly loved at the Brigham and Women’s NICU. Her doctors and was gone. It was so painful that her mom, Lissy, was nurses treated her and loved her back to life. Today, vomiting from the emotional pain. She needed to Marinna is 14 months old, or 10 months corrected. She contact her doctor to get medication to help her sustain is a very social little girl that loves people and always the wake and funeral services. Her gynecologist, has a smile on her face. She is clapping, blowing kisses, Dr. Sarah Catlin, knew about her infertility struggle and and saying “Mum.” She has some medical challenges wanted her to confirm she was not pregnant before but has a wonderful team helping her continue to medication was prescribed. Kindly, Karen Mueller grow and hit developmental milestones. We are in the offered to open the practice early to do the blood test. process of working on our second surrogacy. While seeing Karen, this was a physical reminder for Lissy to mention the lump in her right breast that was What we have learned through these last arduous two causing some pain and pressure. This feeling was years is that we feel so blessed to be surrounded by previously normalized by family and friends stating that so many professionals that we have benefited from it was a “blocked duct” or “part of the breastfeeding their expertise and have made such a positive impact experience.” Being a first-time mom, Lissy wasn’t sure in our lives. They have been with us through the most what was normal. Two and a half weeks later, she was trying and vulnerable times. They have been a large suddenly diagnosed with Estrogen receptive stage 3B part of putting our lives back together and giving us all breast cancer. Lissy and her family were shocked. [We] our children – Evalyn, Marinna, and the baby on the way. had just lost [our] precious daughter, and now, [we] were facing cancer. Her treatment plan consisted of eight Words cannot express how much we rounds of chemotherapy, six weeks of daily radiation, a appreciate everything Brigham and double mastectomy, and 10 years of medication. Before Women have done for us. They are chemotherapy, Dr. Hornstein thankfully introduced us to a large part of our story, and we are Dr. Elizabeth Ginsburg, who leads the oncology-fertility forever grateful.” preservation team for Partners Hospitals. She was so knowledgeable and caring that she began to help us These two reproductive sagas, difficult but similar, clearly articulate one of the core values of the faculty and staff of the Center for Infertility and Reproductive Surgery – to assist individuals and couples to create the family they desire. Clinical Divisions 57

Urban Health Completed Division Members 9 cohorts M. Susan Schilling, MD of participants Assistant Professor, Harvard Medical School in the Health Vows Program Liza M. Swedarsky, MD Instructor, Harvard Medical School Mission The Division of Urban Health exists to provide quality, convenient, and culturally competent health care to women in Boston’s city neighborhoods through our community health centers. Many women prefer to receive care in their neighborhoods with committed providers who have demonstrated an interest in serving diverse communities. The City of Boston was an early pioneer in the expansion and growth of community health centers to address healthcare disparities and inequities that continue to persist today. The Division strives to decrease disparities in outpatient procedural options such as screening and preventing cervical cancer; diagnosing intrauterine pathology causing bleeding disorders through office hysteroscopy; and providing expert care in minimally invasive surgical options such as laparoscopic and robotic gynecologic procedures as well mini-laparotomy and abdominal procedures. Providing accessible, compassionate gynecologic expertise and creating a space for patient education and empowerment are central to our mission. The focus of this Division, extending care mindfully and equitably to a diverse group of women who possess many cultural and socioeconomic challenges, has pre-dated the country’s focus on diversity and inclusion. Fostering diversity and inclusion has been our charge from the beginning and what motivates the providers in Urban Health. The clinicians and leadership of the health centers share the goal that every individual, regardless of income, race, gender, language, or culture, feels welcome and confident they will be provided the best services and care. The Division of Urban Health, prior to the country’s focus on DEI, has already implemented many measures to embrace culturally diverse populations such as having our interpreter services utilize technology, hiring multi-lingual staff, and providing DEI training for all staff. Every patient is served through the lens of identifying and honoring diversity. 58 Department of Obstetrics and Gynecology

Accomplishments in AY 21/22 Our Voices Dr. Schilling: Brookside and South Fighting to eliminate health disparities in our End Community Health Centers community health centers • Continued weekly BWH/MGH Our voice should reflect our patients’ voices and needs. Among the many activities and accomplishments in the Division of Urban Health, Resident PGY2 rotation at Brookside Dr. Liza Swedarsky continues to engage women and offer a space for authentic conversation, healing, and insights by facilitating her • Offered options of laparoscopic Health Vows Workshop Program. The program aims to eliminate health disparities and inequities by offering self-advocacy and tubal ligation and long-acting self-empowerment tools as well as educational topics to heighten reversible contraception health literacy. The series is now enrolling its tenth cohort and is currently an IRB approved research study. She is looking forward • Continued ultrasound guided to sharing all she has learned from the many women who have taken part in the series. Moving to a value-based care system will not Nexplanon removals when needed take into account patient buy-in or accountability. We feel more and mentored other providers in emphasis must be placed on the patients’ journeys as they attempt performing this procedure to navigate all social determinants of health. We must find ways to help patients be stewards of their health care journeys. Stay tuned! • Updated primary care providers on Pap smear guidelines, sterilization, and family planning • Participated as a Clinical Champion with the NIH funded “All of Us” program at Brookside • Participated in oral examinations of HMS students at completion of OB/GYN clerkship Dr. Swedarsky: Southern Jamaica • Hosted a fibroid educational Shared Division Plain Health Center Accomplishments in series aligning with Boston’s local AY 2021/2022 • Completed nine cohorts of social action and non-for-profit organizations aimed to educate • Mentored students in Four participants in the Health women of color Vows Program, a novel health Directions (Dr. Schilling) and mindfulness curriculum and • Presented and partnered with the STARS programs (Dr. Schilling workshop series, designed to and Dr. Swedarsky) change patterns and beliefs that University of Central Lancashire are barriers to health equity. during their Black History Month • Faculty participated in the This seven-part workshop series by presenting and discussing centered around the seven Health disparities in Medical Education family planning/community Vows, and the series promoted health sub-internship for senior mindfulness, self-awareness, and • Presented to the Department of medical students self-empowerment. Participants received tools inspiring them to OB/GYN on the “Importance of navigate complex health care Promoting Health Equity by Targeting systems with confidence Individual Behavior Change” • Granted IRB approval to study the Health Vows Program • Provided access to outpatient MIGS procedures (laparoscopic, robotic, and hysteroscopic), decreasing disparities in surgical options for patients from diverse ethnic backgrounds and socioeconomic status • Adapted robotic surgery teaching for residents utilizing a dual console • Expanded surgical options in health centers for women requiring minimally invasive surgery Clinical Divisions 59

Urogynecology: Female Accomplishments in AY 21/22 Pelvic Medicine and Reconstructive Surgery Dr. Minassian Vatché A. Minassian, MD, MPH, Director • Continued active membership in Associate Professor, Harvard Medical School the Scientific Committee of the Division Members Pelvic Floor Disorders Network, Jeannine Miranne, MD, MS NICHD, NIH and the Research Assistant Professor, Harvard Medical School and Development Committee of Maura Kelly, PA-C, Lead PA the International Urogynecologic Tayler Murray, PA-C Association Alexa Courtepatte, BS, Research Assistant Ana Ramos, Practice Manager • Grant reviewer for the International Mission Urogynecologic Association as a member of the Research and The mission of the Division of Urogynecology Development Committee is to establish a nationally recognized Center of Excellence for female pelvic floor disorders. We • Serving as an epidemiology emphasize equitable care to all in a welcoming, patient-centered, racially, and ethnically diverse practicum mentor for a second practice. We strive for innovation, contributing to master’s in public health program the advancement of medical education, scientific candidate at the Harvard T.H. Chan research, and precision medicine in our field. School of Public Health 60 Department of Obstetrics and Gynecology • Mentoring an International OB/GYN research fellow on several urogynecology research projects • Published four articles in major journals and presented lectures at Brigham and Women’s Hospital • Presented Grand Rounds at the Department of OB/GYN in Beirut, Lebanon • Presented three lectures as part of a master’s class to OB/GYN physicians in Armenia • Participated in medical student, resident, and fellow didactics and clinical education • Directed the Urogynecology Section at the BWH and Harvard Medical School’s 58th Annual Update in OB/GYN Dr. Miranne • Served as course director for the Urogynecology Advanced Elective at BWH • Participated in medical student, resident, and fellow didactics and clinical education • Presented a lecture at the BWH/HMS 58th Annual Update in OB/GYN • Served on the SGS Membership Committee and as a member of the SGS Systematic Review Group

965 Our Voices new patients Increasing access to and improving across urogynecologic care all sites The members of the Division of Urogynecology serve as 576 advocates for women on a daily basis by ensuring our patients receive high-quality, compassionate, and collaborative care. Our surgical cases division has attempted to improve access to care for women across with pelvic floor disorders on a broader scale through both all sites research and teaching. We are committed to investigating potential barriers to urogynecologic care with the ultimate 3,295 goal of creating and implementing solutions to improve health equity. We are currently conducting a study to provide office procedures insight into the reasons why specific patients do not follow performed through for care and no-show their appointments. Based on the findings of this ongoing study, we are planning to solicit funding for a pilot study that will offer transportation for patients in-need as lack of transportation has previously been identified as a barrier to health care. We have also sought to improve care for women with pelvic floor disorders by providing more formalized training for our residents during Urogynecology resident clinic, a new initiative which began during the 2021-2022 academic year. Division Awards/Honors/Promotions Vatché A Minassian, MD, MPH • President, Armenian American Medical Association (Non-profit 501c3 organization based in Boston and covering the whole of New England) • Course Co-Director, The 58th Annual Update in Ob/Gyn Course (Urogynecology), Brigham and Women’s Hospital • NIH Grant Reviewer and Member of Advisory Committee, Pelvic Floor Disorders Network • Research Grant Reviewer, International Urogynecology Association (IUGA) Maura Kelly, PA-C • Promoted to Lead PA Jeannine Miranne, MD, MS • Awarded a Brigham and Women’s Hospital Microgrant Clinical Divisions 61

Donor Stories Diana’s Fibroid Foundation strengthens research for fibroid-related cancers After years of living with uterine fibroids, Diana Leigh Tomkinson and her family were shattered to learn the typically benign growths, in her case, masked a rare, life-threatening sarcoma. Though Diana endured aggressive cancer treatments, the cancer metastasized to her brain, spine, and lungs, and she tragically died in 2020. Determined through their grief to improve detection, understanding, and awareness of fibroid-associated cancers, the Tomkinson family established Diana’s Fibroid Foundation to strengthen research in this area. The family foundation recently committed $100,000 to scientific and education initiatives in the Brigham’s new Center for Fibroids and Complex Uterine Anomalies. “Early detection is critical to preventing the devastation our family endured,” says Blake Tomkinson, PhD, president of Diana’s Fibroid Foundation and Diana’s surviving husband. “We are proud to advance the Brigham’s work to help other families’ wives, mothers, and grandmothers avoid the same struggle as our Diana.” Firsts fuel early detection efforts for ovarian cancer Longtime Brigham patients Debbie First, a survivor of ovarian cancer, and her husband, Bob First, a survivor of prostate cancer, have generously supported cancer research over the years to propel prevention and cures. Recently, the Firsts committed $500,000 for investigations that have the potential to advance early detection of ovarian cancer and other cancers. Their gift will benefit research led by Kevin Elias, MD, the Brigham’s Director of the Gynecologic Oncology Laboratory, in collaboration with Dipanjan Chowdhury, PhD, the Dana-Farber Cancer Institute’s Chief of the Division of Radiation and Genomic Stability. “We have enormous respect for this team,” says Debbie. “They give patients more than medicine; their work is making groundbreaking progress and gives women and their loved ones hope.” Since there are no FDA-approved screening or early detection tests available for ovarian cancer, Elias, Chowdhury, and their colleagues launched the MicroRNA Detection (MiDe) study in 2019 to fill this gap. Their goal is to find a simple, cost-effective blood test that can identify ovarian cancer before women develop symptoms and to ultimately improve survival rates. “We’re tremendously grateful to Debbie and Bob for their partnership in our work and their commitment to our efforts, such as the MiDe study,” says Elias. “With the power of artificial intelligence and machine learning, we’re analyzing microRNAs in the blood to detect ovarian cancer, a method that has promise for other forms of cancer as well. Philanthropy like this allows us to make more rapid progress as we look for ways to find and treat cancer as early as possible.” 62 Department of Obstetrics and Gynecology

Research Divisions 5 Research Labs 8 Active Clinical Trials 5 Active Research Fellows 11 Graduated Research Fellows Research Divisions 63

Cytogenetics Research Accomplishments in AY 21/22 Cynthia C. Morton, PhD, Director • Furthered collaborative William Lambert Richardson Professor Harvard Medical School bioinformatic analyses of the FibroGENE genome-wide association Kenneth J. Ryan, MD, Distinguished Chair analysis (GWAS) to reveal shared in Obstetrics and Gynecology genetic architecture of uterine leiomyomata and breast cancer Division Members Linda Johnson, Senior Grants through a cross-trait analysis Greysha Rivera-Cruz, MD Administrator – retired 9/2021 • Furthered collaborative meta- Hila Romi, MD, PhD Nancy Robertson, Lab Manager – retired 3/2022 analyses of the United Kingdom Caroline Mitchell, Research Biobank (UKBB) GWAS study Project Manager of age-related hearing loss and highlighted the role of the Mission stria vascularis The mission of the Morton laboratory spans longstanding • Established a new humanized interests in applying genetic approaches to inherited human conditions. We seek to gain an understanding of mouse model for gene-editing the biology of uterine fibroids, the genetics of hearing in DFNA9 and delivered the and deafness with implementation of genomics into viral-based therapy newborn hearing screening, and the discovery of genes involved in human development. We do this in the • Used evolving knowledge in the Developmental Genome Anatomy Project (DGAP) through a focus on chromosomal rearrangements that 3D human genome employing disrupt or dysregulate the genome. Specifically, an balanced chromosomal initiative has been launched to develop a non-invasive rearrangements to inform diagnostic for uterine fibroids that can transition into genotype-phenotype a differential diagnosis for uterine leiomyosarcoma. interpretations with a focus Gene editing of the deafness disorder DFNA9 is on the non-coding genome underway in a mouse model using CRISPR-Cas9, and SEQaBOO (SEQuencing a Baby for an Optimal Outcome) • Continued to work collaboratively is piloting genome sequencing in newborn hearing screening. A focus in DGAP is underway to annotate on a national level with PIs of the the role of the noncoding genome in human NIGMS Training Grants in Medical developmental disorders. Through all these research Genetics on issues of common endeavors, outreach is undertaken to promote a concern focused on recruitment of diverse workforce in medical genetics to students underrepresented minorities into attending historically Black universities and colleges. careers in medical genetics 64 Department of Obstetrics and Gynecology • Submitted a competitive renewal application of the NIH T32 Training Grant in Medical Genetics for the Harvard Medical School Genetics Training Program now in its 44th year • Taught a graduate level nanocourse in the Harvard Biological and Biomedical Science Program: Analyzing Genomic Research Data: Keeping the Patient in Mind

Our Voices Empowering women to make their own reproductive choices based on genetic outcomes As a medical geneticist I have experienced firsthand potentially normal outcome to a risk for a child with on numerous occasions the care for women and a serious disorder. Understanding our genome at their families who faced wanted pregnancies with the level of the proteins it encodes and its non- an untoward genetic outcome. I was trained that protein coding regulators will undoubtedly the geneticist’s role was to present the data—an enhance our abilities to become an even more encyclopedia of experience—and to provide non- complete encyclopedia for those who seek our directive counseling. I found myself responding assistance. A choice not to continue a pregnancy is to families on multiple occasions to the question, not one I make for a family but one I must work to “What would I do?” and retreated into the comfort protect for families who face such decisions. zone of stating that I could not offer a meaningful response not knowing what I would do were I in their Both privileged and humbled through my shoes. It is my duty to provide accurate, evidence- laboratory’s DGAP research to have had an based, and unbiased information to empower informed opportunity to improve the knowledge that enables reproductive decisions. There can be no question more informed family choices centered around the that an absence of choice in such situations is freedom of choice, I am proud to use my voice fraught with potential lifelong economic challenges locally in strong support of women’s health and for families in the setting of a disabled child, and the reproductive rights. As a member of the American burden is no doubt largely shouldered by the mother. Society of Human Genetics (ASHG) and a past President of the ASHG, I am honored to serve In our study (known as DGAP: Developmental as Chair of the Government & Public Advocacy Genome Anatomy Project) in which a de novo Committee and to use my voice on a national balanced chromosome rearrangement may be level to support a woman’s right to make her own detected in a pregnancy, a prognosis from analysis reproductive decisions, including, among other of genomic data and any accompanying prenatal options, the right to choose to terminate her clinical findings may lead from a prediction of a pregnancy and to donate fetal tissue for research. Division Awards/Honors/Promotions Cynthia Morton, PhD • Chair, Advisory Board, American Society of Human Genetics, Human Genetics Scholars Initiative (HGSI) • Keynote lecture: “Hearing Across the Lifespan in Generation Genome: Diagnostics and Management from Cradle to Grave”, British Academy of Audiology Annual Conference, Manchester, UK • Distinguished American Cytogeneticist Award from the American Cytogenetics Conference • Chair, American Society of Human Genetics Government & Public Advocacy Committee • CooperSurgical Sponsored Research Agreement: P.I. for Plasma Biomarkers in Women Seeking Treatment for Symptomatic Uterine Neoplasms Research Divisions 65

Gynecologic Oncology Accomplishments in AY 21/22 Laboratory Research Kevin M. Elias, MD, Director Assistant Professor, Harvard Medical School • The microRNA Detection (MiDe) Division Members Study surpassed 350 study Stephanie Cham, MD (Fellow) participants for our prospective Jessica St. Laurent, MD (Fellow) clinical trial using microRNAs for Stephanie Alimena, MD (Fellow) early ovarian cancer detection Kathleen Hasselblatt, Laboratory Manager Bernadette Aidonidis, Sr Administrative Assistant • Dr. Webber presented posters Chaebin Lee, PhD (Postdoctoral Fellow) James Webber, PhD (Postdoctoral Fellow) at the America Association for Laura Wollborn, MD (Postdoctoral Fellow) Cancer Research annual meeting Sudhanshu Mishra, Technical Research Assistant in New Orleans, LA and a Keystone Michele Falzone, Project Data Manager Symposium meeting on small Yick-Fu Wong, MD, PhD, Visiting Scientist regulatory RNAs in Santa Fe, NM Division of Gynecologic Oncology Faculty • Dr. Elias and Dr. Chandrasekaran Ross S. Berkowitz, MD Neil S. Horowitz, MD presented an oral abstract at the Society for Reproductive Michelle R. Davis, MD Michael G. Muto, MD Investigation annual meeting in Denver, CO entitled “PAX8-Directed Sarah Feldman, MD, MPH Michael J. Worley, Jr., MD Nanotherapeutics for High-Grade Serous Ovarian Cancer” Colleen M. Feltmate, MD Education Mission • Drs. Elias, Berkowitz, and Horowitz Our mission is to perform multidisciplinary, innovative, collaborative, and equitable research authored five textbook chapters to benefit all women through improvements in the and six different UpToDate prediction, prevention, diagnosis, and treatment of entries on various aspects of gynecologic cancers. the management of gestational trophoblastic disease • Dr. Elias gave a master class on “Strategies to Evaluate and Improve Compliance to Surgical Pathways” during the Society of Gynecologic Oncology meeting in Phoenix, AZ • The Laboratory hosted Monica Moore, a rising junior from Howard University, and Sharra Lewis, a rising sophomore from UMass Boston, as summer interns through the DFCI summer mentors program The annual Mighty Moose 5K Race in Concord, MA raised $340,000 to support the laboratory’s early detection programs. 66 Department of Obstetrics and Gynecology

Our Voices Investigating if race and ethnicity impact accuracy of early detection tests The Gynecologic Oncology Laboratory has been breast cancer to ensure these tests distribute their hard at work with an increasing focus on the benefits equally among diverse populations. We prediction and prevention of gynecologic cancers. will also make this data publicly available for the In developing new technologies for cancer risk greater research community to mine. assessment, the Laboratory has been actively seeking to ensure that the assays we create are In the year ahead, we plan to expand our widely applicable to diverse populations. Working understanding of cancer screening at a population with the Mass General Brigham Biobank, we have level by looking at the effects of geographic assembled a cohort of 10,000 serum samples from location on cancer risk profiles. We hypothesize women treated at an MGB institution with at least that certain neighborhoods within our treatment one appointment with a gynecology provider. This area may harbor high-risk communities for cohort includes more than 2,000 samples from cancer as reflected through circulating biomarker women identifying as an underrepresented minority profiles. Understanding the relationship between group. We have been investigating the impact of cancer biomarkers and neighborhoods may help race and ethnicity on the accuracy of proposed focus cancer screening efforts as well as reveal early detection tests for ovarian, endometrial, and environmental exposures that impact cancer risk. Division Awards/Honors/Promotions Dr. Cham received a 2022 Conquer Cancer Young Investigator Award from the American Society of Clinical Oncology. Dr. Elias and Dr. St. Laurent shared the Rogerio Lobo Award from the Society for Reproductive Investigation, awarded to the year’s best paper in Reproductive Sciences. Dr. Elias received a $50,000 National Early Detection Research Award from the Minnesota Ovarian Cancer Alliance for his proposal \"Cellular communication at the ovarian-fallopian tube interface.” Dr. Elias and collaborators received a $25,000 Developmental Research Program Award from the Dana-Farber Ovarian Cancer Spore for the project entitled “Circulating miRNA signatures associated with defects in DNA repair.” Dr. Elias and collaborators received a $100,000 2022-23 Individual Investigator Award from the Honorable Tina Brozman Foundation for the project “Circulating microRNA signatures among BRCA1/2 mutation carriers.” Dr. Elias and collaborators were awarded a $600,000 Translational Award from the V Foundation for their project entitled “Blood-based screening for identification and monitoring of women at elevated risk for breast and ovarian cancer.” Research Divisions 67

Laboratory of Accomplishments in AY 21/22 Genital Tract Biology • Our mission has been met Raina N. Fichorova, MD, PhD, MA (Hon), Director Professor, Harvard Medical School by recruiting and nurturing a The Walter Channing, MD, Distinguished Chair diverse research force (80% in Obstetrics and Gynecology underrepresented in research and medicine) contributing to over 200 Division Members peer-reviewed publications, over Hidemi S. Yamamoto, BA, Lab Manager 9,900 citations, and in academic Stephanie Nartey, BS, Senior Research Technician year 2021-2022 alone – 17 funded Claire King, MPH, Research Coordinator research projects. In the past Julie Lewis, BS, Research Technician academic year we continued to Maya Gordon, BS, Research Technician make progress in the following top Ngan Luu, BS, Research Technician 10 high-impact research areas: Ana Martinez-Torres, STARS Program Research Trainee 1) the role of inflammation, Gemima Germain, SSJP Student Intern microbiome, and vaginal dysbiosis Joshua Davis, STARS Program Research Trainee in women’s health; 2) perinatal inflammation and placental Mission epigenome as predictors of child health and neurodevelopment; The overarching mission of the Genital Tract Biology 3) Lactobacillus-based Division is to improve reproductive and sexual health biotherapeutics and biome-friendly while fighting disparities through research and training contraceptives; 4) the role of parasite the new diverse and united generation of biomedical exosomes and parasite viral scientists. Toward this mission, we focus our endosymbionts in host immunity; research and innovation on advancing fundamental 5) targeting dysbiosis for cervical biology, prevention, and cure of high-impact cancer prevention; 6) immune inflammatory conditions. biomarkers of cancer and depression; 7) Immunopathogenesis of 68 Department of Obstetrics and Gynecology endometriosis; 8) hormonal contraception in mucosal immunity and resistance to infection; 9) miRNAs regulation of drug metabolism and transport in pregnant and lactating women; 10) miRNAs regulation of systemic immunity and susceptibility to infection. • Our top innovative research made the news in “Hospital on a Mission” titled: “Improving Microbial Balance in the Female Genital Tract May Boost Health Outcomes” and “Galectin Mediated Immunity is Regulated in Protozoan Viral Bacterial Female Genital Tract Infections.” • Among the achievements and awards of our team members this year are a patent granted to Dr. Fichorova and Hidemi Yamamoto on the first vaginal live biotherapeutic developed at BWH, the promotion of Stephanie Nartey to Senior Research Technician, Maya Gordon’s acceptance in Medical School, and our STARS Scholar’s first peer-reviewed publication and first research position at BWH.

Our Voices Conducting innovative research to assist in women’s sexual and reproductive health Protecting women’s reproductive rights and demand female-controlled contraception and develop combating disparities in reproductive health our Brigham-patented medicinal vaginal bacterial have been the context for the research conducted cocktail designed to promote and restore a healthy in the Laboratory of Genital Tract Biology since female genital tract microbiome. The laboratory also its inception nearly two decades ago. Dr. Raina investigates biomarkers of immune function and Fichorova founded this research division with the safety in clinical trials such as the ongoing UCHOOSE focus on science serving all women regardless of trial, a multi-center, multi-racial clinical trial designed race, gender, or socioeconomic status. Our research to assess the impact of contraceptives on the fosters understanding the biology that informs safe cervicovaginal mucosa. Under NIH funding, the reproductive choices and interventions to reduce Laboratory studies hormone-regulated epigenetic risk of unwanted pregnancies, stress, infections, mechanisms of the host-microbiome equilibrium and adverse maternal and newborn outcomes. By including microRNA pathways to allow selection defining health of the genital tract microenvironment of most-biocompatible contraceptive modalities. and designing algorithms for assessing immunobiome safety in the context of both contraception and Dr. Fichorova was co-awarded the Women’s pregnancy, our team aspires to empower both Reproductive Health Research (WRHR) grant to healthcare providers and women to maintain sexual serve as a K12 Research Director mentoring and and reproductive health. promoting the next generation of OB/GYN clinician scientists to become advocates for equitable The most recent innovative research conducted in the health and reproductive rights. Our hope is the Laboratory of Genital Tract Biology includes creating research conducted by the Laboratory of Genital and refining in vitro human models using immortalized Tract Biology on the proteomic, epigenomic, and cell lines generated by Dr. Fichorova at the Brigham. social levels will continue to provide knowledge These cell lines were used to test novel technologies and education empowering women’s safety and such as a SMART tampon device to provide on- right to reproductive health and wellness. Division Awards/Honors/Promotions Raina Fichorova, M.D., Ph.D. • Elected Vice Chair for Research in OB/GYN • Named Editorial Board Reviewer for the 2022 NIH Director’s New Innovator Award Program (DP2). • Chair, NIH Fellowship Panel in Infectious Diseases and Immunology Study Section • Named to BWH Ob/Gyn Diversity and Inclusion Committee • Named to Committee on Senior Appointments (COSA) at BWH • Named to the HMS Promotion and Reappointment Committee • Research Director, Harvard Women’s Reproductive Health Research K12 Training Program • PI or site-PI on three new federal awards • Core Faculty, HMS Research Divisions 69

OB/GYN Epidemiology Accomplishments in AY 21/22 Center • Dr. Sasamoto was awarded an NCI Daniel W. Cramer, MD, ScD, Director R03 to investigate the association Professor, Harvard Medical School between breastfeeding and reduced ovarian cancer risk by examining Division Members blood biomarkers that mediate and Kathryn L. Terry, ScD modify this association Associate Professor, Harvard Medical School Naoko Sasamoto, MD, MPH • Dr. Sasamoto was invited for an Assistant Professor, Harvard Medical School Bernadette Aidonidis, Sr. Administrative Support oral presentation at the 2021 Ana Babic, PhD, Per Diem Programmer American Society of Reproductive Instructor in Medicine, Harvard Medical School Medicine annual meeting Mary DePari, BS, Statistical Programmer Cameron Fraer, BSN, Project Coordinator • Our team was awarded NIH funding Allison Vitonis, MS, Data and Biorepository Manager Shruthi Sudhakar, BA, Senior Research Assistant to identify genetic variants associated Ashley Laliberte, MPH, Statistical Programmer with endometriosis subphenotypes Jennifer Mongiovi, PhD, Postdoctoral Fellow T.H. Chan School of Public Health, Epidemiology • Our team published a paper in Human Reproduction highlighting circulating proteomics profiles associated with endometriosis in adolescents and young adults In the AY2021/2022, we: published 28 original reports including 6 first- authored and 4 last-authored papers Mission submitted Conduct innovative, quality epidemiologic research 23 grant that improves prevention, early detection, and treatment of women’s health problems and train or subcontract those who aspire to perform epidemiologic research applications in reproductive health. 70 Department of Obstetrics and Gynecology

Our Voices Aiming to decrease delay in endometriosis diagnosing Several of our new and pending awards as Recent work led by Dr. Sasamoto highlights well as publications from AY2021-2022 focus on proteomic signatures in adolescents and young endometriosis-associated pelvic pain. Notoriously women with endometriosis compared to controls difficult to diagnose, the time between symptom that highlight potential markers to explore for onset and endometriosis diagnosis averages seven diagnostic tests as well as identify pathways that years, resulting in prolonged pain symptoms. may be explored for novel therapeutics. Decreasing Persistent endometriosis associated pain greatly the delay to diagnosis and discovering novel impacts women physically, psychologically, and targets for therapeutic development provides economically over the life-course through missed girls and women the tools they need to make their work or school and reduced social engagement. voices heard. In addition, we will use our voices Without a better understanding of risk profiles through grant applications and publications to and a noninvasive test, adolescents and young highlight these problems, research their causes women are voiceless. and consequences, and identify novel methods to prevent, detect, and manage endometriosis better. We were awarded: 11 grants or subcontracts with 5 fully executed and 6 pending set up Division Awards/Honors/Promotions Naoko Sasamoto, MD, MPH, PhD was promoted to Assistant Professor on June 1, 2022. Research Divisions 71

Reproductive Accomplishments in AY 21/22 Endocrinology and Infertility Research • Fertility Preservation in cancer Raymond M. Anchan, MD, PhD, Research Director patients: Dr. Ginsburg and colleagues have strived to Mark D. Hornstein, MD, Division Director investigate novel approaches for Andrea Lanes, MSc, PhD, Epidemiology and fertility preservation in pediatric Clinical Database Research and adult cancer patients, including ovarian tissue cryopreservation, Division Members Zachary Walker, MD (Fellow) pre-chemotherapy oocyte banking, Raymond M. Anchan, MD, PhD Anna Vanderhoff, MD (Fellow) and research into understanding Rachel K. Ashby, MD Margeaux Oliva, MD (Fellow) the systemic impact of cancer on Robert L. Barbieri, MD fertility and ovarian responses Janis H. Fox, MD Denise Galotti, Administrative Antonio R. Gargiulo, MD Support • IVF treatment and pregnancy Elizabeth S. Ginsburg, MD Kimberly W. Keefe Smith, MD Physician’s Assistant outcomes: Dr. Andrea Lanes directs Marc R. Laufer, MD Allison Ruhe, PA-C the Division’s epidemiologic and Serene S. Srouji, MD clinical database research. Utilizing Elena H. Yanushpolsky, MD Laboratory Personnel the Division’s database of over Brian W. Walsh, MD Maya Seshan, BS, Study 10,000 IVF cycles her research Coordinator focuses on quality assurance Catherine Gordon, MD (Fellow) Anne Lindholm, BS, Research and quality improvement projects Jenny George, MD (Fellow) Assistant within the Center for Infertility Nicholas Ng, BS, Research and Reproductive Surgery, Assistant the impact of preimplantation genetic testing on placentation, Mission and adverse birth outcomes associated with IVF treatment Our research mission is to do innovative and cutting-edge multicenter fertility and gynecologic • COMPARE UF (comparing options research to advance women’s health, improve therapeutic options, and enhance holistic equal for management of uterine care for all of our patients. We also strive to train fibroids, patient centered results) the next generation of academic and clinical was completed and resultant leaders in reproductive endocrinology and infertility. manuscripts are in preparation. Study: The Center for Infertility 72 Department of Obstetrics and Gynecology and Reproductive Surgery (CIRS) completed the fifth year as the primary coordinating site in New England for COMPARE UF, a five- year multicenter study funded by the Agency for Healthcare Research and Quality (AHRQ) and the patient- centered outcomes research institute (PCORI), involving a consortium of ten national institutions to establish a National Registry of Patients with Symptomatic Uterine Fibroids. Site PI (Raymond Anchan, CIRS/BWH) Study PI (Evan Myers, Duke University) • UP FRONT (uterine fibroid option grid) Clinical Trial (NCT03985449): CIRS completed the pre- implementation and implementation phases of this fibroid treatment tool-option grid study and are currently in the sustainability phase of the study. BWH OB/GYN

Our Voices Advocating for coverage of fertility services for patients on publicly funded insurance As Reproductive Endocrinologists and Infertility access to fertility care. We are therefore also specialists we firmly believe that access to care for exploring novel approaches to provide low-cost fertility is a basic reproductive right for our patients. care and engage primary care providers in the initial As such we are endeavoring to address this with management of fertility treatment for patients, multiple initiatives including education of patients thereby improving and expanding access to fertility regarding available insurance and pharmaceutical treatment. Furthermore, our future endeavors will resources for accessing care. This is in part is being investigate philanthropy and its potential role in achieved by compiling a comprehensive document providing care on an individual, need-based, case- that will help introduce patients to available resources by-case approach. In addition to this several of our and patient advocacy groups such as RESOLVE. While faculty and staff remain engaged at the legislative we are fortunate to practice medicine in a state with level advocating for changes to our state healthcare mandates for fertility coverage, patients with publicly mandates to include publicly funded insurance funded insurance still are unable to have equal coverage for fertility care. enrollment of patients in the • CLINICAL INNOVATION: Two Diversity, equity and UP FRONT multicenter clinical trial is part of a five-institution Clinical Centers of Excellence inclusion initiatives collaborative research team funded for the Management of Uterine by PCORI. Site PI (Raymond Fibroids and Endometriosis The Faculty of the Center for Anchan, CIRS/BWH) Study PI established during 2021 have Infertility and Reproductive Surgery (Glyn Elwyn, Dartmouth College) been advanced and proposals have identified that access to developed to request institutional fertility treatment is a healthcare • Cabergoline for the Treatment support during 2022 and beyond. gap that disproportionately impacts economically disadvantaged of Chronic Pain Due to • o BWH Center for Fibroids and populations. Therefore, developing Endometriosis Clinical Trial strategies to ameliorate this (NCT03928288): Collaborative Complex Uterine Anomalies — situation and be able to make fertility study with Boston Children’s The center for excellence for the care accessible to more people is a Hospital and the Boston Center comprehensive management of major Divisional initiative for 2022. for Endometriosis funded by the Complex Uterine Anomalies is co- Department of Defense. Site PI directed by Drs. Antonio Gargiulo/ (Mark Hornstein, CIRS/BWH) CIRS and Dr. Ajao Bolaji/MIGS Study PI (Amy DiVasta, BCH) • o BWH Center for Endometriosis • Neuropathic Pain Marker Treatment, which has the goal Expression in Endometriosis of streamlined comprehensive Patients with Chronic Pelvic patient-centered care, is Pain: Study funded by the co-directed by Drs. Louise Marriott’s Daughters Foundation/ King (MIGS) and Raymond Boston Center For Endometriosis. Anchan (CIRS) Site PI (Raymond Anchan, CIRS/ BWH) Grant PI (Marc Laufer, BCH) • Fertility Preservation in the • New 2022 funding from the Pediatric Population: Director Dr. Elizabeth Ginsburg, along with a Dick Marriott Endometriosis collaborative clinical team including Research Grant Award to the Drs. Gargiulo, Srouji, Ashby, Smith- Anchan laboratory Keefe, and the Technical Embryology Director Jay Patel, have successfully cryopreserved pediatric ovarian tissue with the intent of future fertility restoration. Research Divisions 73

Donor Stories Marinos bring social work resources to women in need When Kathy and Roger Marino established a family foundation, they thought “I’m inspired by of supporting the Brigham in gratitude for the outstanding care Kathy received Dr. Nour’s commitment,” from Brian Walsh, MD, in the Department of Obstetrics and Gynecology. Kathy says. “It’s an honor to help build Kathy reached out to learn how they could help and heard from department a bridge for women chair, Nawal Nour, MD, MPH, about efforts to treat patients holistically. This to resources in the includes assisting patients with challenges that affect their overall health community, so they and well-being such as housing or financial instability, interpersonal violence, can live as happily and depression, and substance use. healthily as possible.” The couple gave $200,000 through the Roger and Kathy Marino Foundation to support a social worker position in obstetrics and gynecology who will connect women with shelters, domestic violence services, and other resources. Higgins’ gift propels rare cancer research While facing gynecologic cancer, Andrea Higgins received loving support from her husband, Keith, and compassionate, skilled care from Brigham gynecologic oncologist Neil Horowitz, MD. After Andrea’s passing, Keith reflected on how he could honor her life by supporting medical research led by Horowitz, a leader in his field and associate professor in the Department of Obstetrics, Gynecology, and Reproductive Biology. After consulting with Horowitz on areas of great need, Keith gave $500,000 to establish the Andrea S. Higgins Research Fund at the Brigham. The fund will enable Horowitz to launch new investigations into the biological makeup of a rare cancer known as gestational trophoblastic disease (GTD). Roughly one in 1,000 pregnancies in the U.S. develop hydatidiform mole, a benign form of GTD. The majority of these resolve, but some can become cancerous and spread throughout the body. Rarely, malignant GTD can also occur after normal or ectopic pregnancies and miscarriages. “We are honored that Keith entrusted us with this meaningful gift in Andrea’s memory,” says Horowitz. “Thanks to him, we will launch several early-stage studies that could pave the way for new GTD treatments and prevention strategies that help patients.” Horowitz co-directs the New England Trophoblastic Disease Center at the Brigham, which houses the nation’s largest GTD biospecimen registry. His team also collaborates with medical centers in Brazil and the United Kingdom to collect additional biospecimens for examination. With these resources, they will analyze GTD patients’ stored tissue and blood samples to better understand the disease’s molecular makeup and hopefully identify new targets for therapy. “Throughout Andrea’s illness, I was grateful for the skill and compassion of Dr. Horowitz and the gynecologic oncology residents,” Keith says. “His whole team took such good care of Andrea and were a great help to me, too. I’m grateful for the opportunity to support his research and make a difference in others’ lives.” 74 Department of Obstetrics and Gynecology

Research Support Publications Publications is available electronically. Scan the QR code to the right to view. FPO 81 Active Grants 126 Research Funds $8,640,999 in research spending Research Support 75

Research Support Raymond M. Anchan, MD, PhD Medical Director, 2015-2023 Principal Investigator, 2020-2025 • Title X Federal Family Planning Services Grant • 3M Company (3M): 2020-ISR-000157 Clinical Services Award Covid-19 CTA: Phase I/II Trial (Safety and Dosing) Director, 2010-2023 of Povidone-iodine (PVP-I) nasal swab for preventing COVID-19 spread in healthy subjects • Kenneth J. Ryan Program Principal Investigator, 2020-2022 Educational Program Grant • Marriott Daughter’s Foundation via Boston David Cantonwine, PhD Children’s Hospital Principle Investigator, 2022-2023 Generation of patient specific induced pluripotent stem cell from endometriosis tissue • President and Fellows of Harvard College: Subrecipient Principal Investigator, 2018-2022 027269.746796.0016 Environmental toxins: Everyday exposures - • PCORI: SDM-2017C2-8507 (Jones-Elwyn) Toxins and Health Multi-component implementation of SDM for uterine Co-Investigator, 2021-2023 fibroids across socio-economic strata • HHSN273201600003I/HHSN27300002 (Ferguson), Deborah Bartz, MD, MPH NIH/Social and Scientific Systems, Inc. Principal Investigator, 2021-2023 NIEHS LIFECODES environmental chemicals and fetal growth case-cohort study • Expanding the Boundaries Co-Investigator, 2019-2025 An exploratory analysis of diversity in representation in medical art within a major medical journal • Mirvie, Inc. (McElrath) Principal Investigator, 2020-2022 MicroRNA to predict spontaneous preterm birth • Expanding the Boundaries Co-Investigator, 2016-2021 Population attitudes toward contraception methods • NIH 5R01ES026166-05 (James-Todd), HSPH over time on a social media platform Phthalates, gestational diabetes, and markers of Principal Investigator, 2020-2022 type 2 diabetes risk in women • Expanding the Boundaries Daniela Carusi, MD, MPH National practices, barriers to, and facilitators Principal Investigator, 2019-2024 of postpartum tubal ligation fulfillment: A mixed-methods study • Hess Foundation Principal Investigator, 2019-2022 Hess Foundation Fund for Placenta Accreta • Expanding the Boundaries Co-Investigator (effective 11/01/20), 2018-2022 Hormonal contraception and headache frequency: • NIH R01HD067270-11 (Stern) A cohort study Dartmouth-Hitchcock Clinic Principal Investigator, 2019-2022 MOSART REVISION - Subfertility and assisted conception study of parent and child health outcomes • Expanding the Boundaries Residency training in trauma informed care: A national assessment 76 Department of Obstetrics and Gynecology

Daniel W. Cramer, MD, ScD Jon Einarsson, MD, PhD, MPH Principal Investigator, 2016-2023 Principal Investigator, 2019-2021 • NIH 1R35CA197605-06 • Brigham And Women’s Biomedical Research Mucin and immune cell interactions in ovarian cancer Institute (BRI) pathogenesis & progression The O-Scope, a novel screening tool for ovarian cancer and endometriosis Khady Diouf, MD Kevin Elias, MD Subrecipient Principal Investigator, 2021-2022 Principal Investigator, 2022-2023 • Massachusetts Department of Public Health, • The Honorable Tina Brozman Foundation, Inc Centers for Disease Control and Prevention Circulating microRNA signature among BRCA1/2 Specialized health and safety projects provided mutation carriers by organizations Principal Investigator, 2022-2023 Subrecipient Principal Investigator, 2020-2022 • Minnesota Ovarian Cancer Alliance • NIH, 2P30AI060354-16 (Walker), President and Cellular communication at the ovarian-fallopian Fellows of Harvard College tube interface Addressing unmet HIV prevention and sexual health needs among African born Black women Principal Investigator, 2021-2025 Sarah Rae Easter, MD • Dana Farber Cancer Institute Principal Investigator, 2021-2022 Dana-Farber/Harvard Cancer Center ovarian cancer SPORE grant (CEP) • AMAG-SMFM Policy Award, ASRM Principal Investigator, 2021-2025 A comprehensive obstetric transport review process to improve equitable access to regionalized maternity care • Dana Farber Cancer Institute Principal Investigator, 2019-2022 Dana-Farber/Harvard Cancer Center Ovarian Cancer SPORE grant (DRP) • The Risk Management Foundation of the Harvard Principal Investigator, 2021-2022 Medical Institutions Incorporated (CRICO) Establishing an obstetrics critical care program to • Dana Farber Cancer Institute mitigate maternal risk BCRA-associated circulating miRNA signatures Katherine Economy, MD Principal Investigator, 2020-2023 Subrecipient Principal Investigator, 2022-2023 • Abcam Inc. • AHA, 2022A003803: MGH, (Honigberg) Generation of a circulating miRNA profile dataset Health-related social needs and the risk of hypertension in young adult and early midlife women: The impact Principal Investigator, 2019-2022 of pregnancy • Mass Life Sciences Center Mentored Principal Investigator (Valente), 2015-2022 Serum miRNA neural networks for early diagnosis • BWH’s Linda Joy Pollin Women’s Heart Center of cancers in women Innovation Award Cardiovascular disease and exercise in pregnancy Research Support 77

Research Support Kathryn Fay, MD, MSCI Site Principal Investigator, 2021-2023 Scholar, 2021-2025 • Inova Health System/ Children’s Research Institute • NIH-NICHD 1K12HD103096-01 CLT0000152845 Fetal and neonatal biomarkers after preterm premature Trans-disciplinary Harvard WRHR Career Development rupture of membranes (PPROM) for Gynecologists and Obstetricians Validating a reproductive coercion scale Co-Principal Investigator, 2021-2023 Sarah Feldman, MD, MPH • NIH/Glyciome, LLC: R41CA254543 Principal Investigator, 2021-2022 SBIR: CTA: Cervical cancer prevention prebiotic Device • Society to Improve Diagnosis in Medicine Principal Investigator, 2020-2025 Improving colposcopy rates for women screened • Evans Philanthropic Research Gift for cervical cancer: Actively managing care among women at risk Immunopathogenesis of endometriosis Site Principal Investigator, 2019-2023 Research Director, 2020-2025 • NIH- 5UM1CA221940-05 • 1K12HD103096-01 Multi-level optimization of the cervical cancer screening Transdisciplinary Harvard WRHR career development process in diverse settings & populations (METRICS) for gynecologists and obstetricians Site Principal Investigator, 2018-2023 Site Principal Investigator, 2020-2025 • NIH- U01CA225451 • Office of the Vice President of Research University Promoting follow-up of abnormal cancer screening of Michigan, MSU and WSU tests using population-based systems to support The role of genetic and epigenetic regulation of PUFA stepped care multilevel intervention metabolism pathway in placental inflammation and newborn health Colleen M. Feltmate, MD Principal Investigator, 2020-2021 Principal Investigator, 2020-2023 • NIH-NICHD 3R01HD099091-02S1 • Dana Farber Cancer Institute MicroRNAs as regulators of drug metabolism and DFCI-BWH Integrated Fellowship Fund transport in pregnant and lactating women Raina N. Fichorova, MD, PhD Site Principal Investigator, 2020-2021 Site Principal Investigator, 2021-2024 • Office of the Vice President of Research University • NIH/ St. Louis College of Pharmacy R33HD099748 of Michigan, MSU and WSU Air pollution and placental inflammation: SMART Polymer fibers for tampon-like nonsteroidal Understanding the role of maternal nutrition contraceptive devices Site Principal Investigator, 2020-2021 Site Principal Investigator, 2021-2023 • Office of the Vice President of Research University • USAID/EVMS: 7200AA20CA00019 of Michigan, MSU and WSU Sample analysis and data interpretation in support The maternal microbiome and infant outcomes in of project UChoose MARCH (MoM-Mi) Site Principal Investigator, 2020-2021 • University of Rochester VDAART: Vitamin D antenatal asthma reduction trial 78 Department of Obstetrics and Gynecology

Site Principal Investigator, 2020-2021 Antonio Gargiulo, MD • NIH/UNC 5UH3OD023348-05 Principal Investigator, 2016-2026 Environment, epigenetics, neurodevelopment & health • Thomas Kosasa, MD, Philanthropic Research Gift of extremely preterm children Uterine transplant research fund Principal Investigator, 2019-2024 Elizabeth Ginsburg, MD • NIH-NICHD 5R01HD099091-02 Multi-Principal Investigator, effective (11/01/20), MicroRNA predictors of HIV Risk in reproductive 2017-2022 age women • NIH 5R01HD092550-03 (Racowsky/Ginsburg) Mentor/Laboratory Site Principal Investigator, 2018-2023 Causes and consequences of mitochondrial • NIH 1K07CA225403 dysfunction in oocytes and cumulus cells Role of anal microbiota, local cytokines and HIV in Alisa Goldberg, MD, MPH persistence of high‐risk human papillomavirus Site Principal Investigator, 2021-2024 Co-Investigator, 2018-2021 • MK8415-060: Merck • NIH-NINR 5R21NR017256-02 A Phase 3, open-label, multi-center, single arm study The influence of the milk microbiome on inflammation to assess contraceptive efficacy and safety of the of the preterm infant etonogestrel (MK-8415) implant during extended use from 3 years after insertion in females 35 years of age Principal Investigator, 2018-2021 or younger • BWH Health & Technology Innovation Award Subrecipient/Site Principal Investigator, 2021-2022 Medicinal vaginal Lactobacillus cocktail • Planned Parenthood Federation of America Mentor/Laboratory site Principal Investigator, 2017-2023 Minimal contact medication abortion (MCMAB): A hybrid effectiveness-implementation study • NIH 1K23HD091390-02 Mentor, 2021-2023 The roles of perinatal nutrition, infection and inflammation • Society of Family Planning Research Fund in the neurodevelopment of Bangladeshi infants Expanding abortion gestational limits in MA: Site Principal Investigator, 2017-2022 Implications of the ROE Act • NIH 5R01 HD092374-03 Mentor, 2021-2022 Placental epigenome and brain dysfunction after • Society of Family Planning Research Fund & Planned preterm birth Parenthood Federation of America Co-Investigator, 2016-2023 The impact of intimate partner violence (IPV) on abortion method • NIH 5R35CA197605-05 Subrecipient/Site Principal Investigator, 2020-2022 Mucin and immune cell interactions in ovarian cancer pathogenesis & progression • University of Pennsylvania Site Principal Investigator, 2016-2023 RhIMAB: A prospective trial to re-assess the value of Rh immune globulin in medication abortion • NIH 5UH3OD023285-05 service provision Prenatal exposures and child health outcomes: A statewide study Research Support 79

Research Support Alisa Goldberg, MD, MPH (continued) Kathryn Gray, MD, PhD Mentor, 2019-2021 Subrecipient Principal Investigator, 2022-2027 • Society of Family Planning Research Fund • 1R01HL163234-01, (Saxena) Mifepristone use among Massachusetts Integrative omics of preeclampsia in TOPMED and obstetrician-gynecologists maternal cardiovascular health Principal Investigator, 2018-2021 Co-Investigator, 2021-2026 • Society of Family Planning Research Fund • R01 HD104646-02 (Huybrechts/Wang, MPI Mifepristone and misoprostol for undesired pregnancy Active surveillance of the safety of antipsychotic of unknown location (MAPUL) medications in pregnancy Subrecipient/Site Principal Investigator, 2018-2021 Co-Investigator, 2021-2026 • NICHD, Contraceptive Clinical Trial Network: • NIH R01 HD081256 (Talkowski) Subcontract from Columbia University Clinical diagnostic sequencing of structural variation A multi-center, randomized study of the efficacy of ulipristal acetate (UPA) 30 mg, Levonorgestrel (LNG) Co-Investigator, 2021-2025 1.5 mg and LNG 3.0 mg for emergency contraception (EC) in women with weight > 80kg. • 1R01HL153625-01A1 (Rexrode/Rich-Edwards, MPI Mentor, 2018-2021 Using metabolomics to understand CVD risk in women with a history of preterm delivery • Society of Family Planning Research Fund Co-Investigator, 2021-2025 Medication abortion for women with undesired pregnancy of unknown location: A randomized • NIH R01 HD105266 (Talkowski/Wapner/ controlled trial (MAPUL II) Wilkins-Haug, MPI) Subrecipient/Site Principal Investigator, 2017-2022 The genomic architecture of pregnancy loss • FHI 360 (site): NICHD Contraceptive Clinical Subrecipient Principal Investigator, 2021-2024 Trial Network • 870754, Simons Foundation, Inc., via MGH (Edlow A multi-center, single-blind, randomized clinical trial to compare two copper IUDs: Mona Lisa NT Cu380 COVID PRISM: COVID-19 Pregnancy registry of immune Mini and Paragard responses and maternal microbiome Catherine Gordon, MD (Fellow) Multi-Principal Investigator (Gray/Saxena), 2021-2022 Mentored Principal Investigator • Preeclampsia Foundation (Racowsky/Ginsburg), 2021 Multi-omics for precision medicine in preeclampsia • New England Fertility Society Multi-Principal Investigator (Casas/Gray), 2020-2024 Improving yield of mature oocytes for oncofertility patients • NIH X01 HL153753-01 (resource access grant Boston-Colombia collaborative adverse pregnancy outcome study Co-Investigator, 2020-2023 • NIH 1R01DA049822-01 (Bateman/Huybrechts, MPI) The comparative effectiveness and safety of pharmacotherapies for the treatment of opioid use disorder in pregnancy Principal Investigator, 2019-2023 • NIH 1K08HL146963-04 Signatures of dysfunctional mitochondrial fatty acid oxidation that predispose to early-onset preeclampsia 80 Department of Obstetrics and Gynecology

James A. Greenberg, MD Thomas F. McElrath, MD, PhD Principal Investigator, 2017-2023 Subrecipient Principal Investigator, 2021-2025 • CTA: TRUST Study, Halt Medical, Inc., Clinical Trial • NIH: 1R01ES031591-02 (Meeker) The TRUST (Treatment results of uterine sparing Development and application of methods analysis technologies) of chemical mixtures and their association with birth outcomes Susan Hellerstein, MD Subrecipient Principal Investigator, 2021-2023 Principal Investigator, 2017-2023 • HHSN273201600003I/HHSN27300002 (Ferguson) • Anna and John Sommers Philanthropic Research Gift NIH/Social and Scientific Systems, Inc. Maternal Health Research and Education Fund NIEHS LIFECODES environmental chemicals and fetal growth case-cohort study Mark Hornstein, MD Principal Investigator, 2019-2025 Subrecipient Principal Investigator, 2019-2023 • Mirvie, Inc. • AMRMC W81XWH1910219 (DiVasta), Boston MicroRNA to predict spontaneous preterm birth Children’s Hospital Novel, non-hormonal therapy for the treatment of Sponsored Investigator, 2019-2024 chronic pain due to endometriosis in adolescent and adult women • The Sidman Family Research Fund Elizabeth Janiak, ScD Co-Investigator, 2018-2023 Principal Investigator, 2022-2023 • NINDS 2U01NS038455-16A1 (Pennell) • Society of Family Planning Research Fund Maternal outcomes and neurodevelopmental effects of antiepileptic drugs (MONEAD II) Abortion access for marginalized young people after Roe: A mixed-methods study Subrecipient Principal Investigator, 2016-2021 Subrecipient Principal Investigator, 2022-2023 • NIH 5R01ES026166-06 (James-Todd), HSPH • (Stulberg), University of Chicago via Argosy Phthalates, gestational diabetes, and markers of type 2 diabetes risk in women Foundation, The Irving Harris Foundation, Lisa & Douglas Goldman Fund Vatché Minassian, MD, MPH Medication Abortion Learning Collaborative, ExPAND Mifepristone Principal Investigator, 2018-2021 Principal Investigator, 2021-2023 • International Urogynecological Association • NIH 1R21HD103977-01A1 Urinary microbiome and inflammatory response in postmenopausal women with urgency urinary Birth control to improve birth spacing (BIBS) incontinence before and after anticholinergic treatment Subrecipient Principal Investigator, Project Co- Investigator, 2018-2023 • Commonwealth of Massachusetts, Executive Office of Health and Human Services Boston Medical Center (Coordinating center/ primary grantee) Partners in contraceptive choice and knowledge Research Support 81

Research Support Jeannine Miranne, MD, MS Naoko Sasamoto, PhD Principal Investigator, 2019-2022 Principal Investigator, 2022-2024 • Expanding the Boundaries Grant (BWH) • NIH - 1R03CA259659-01A1 Urinary microbiome in women taking cranberry Using biomarkers to elucidate the breastfeeding and capsules and nitrofurantoin ovarian cancer risk association Principal Investigator, 2022-2023 Principal Investigator, 2021-2025 • Brigham Research Institute Award (BRI) • U.S. Army Medical Research Acquisition Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) Activity - W81XWH-21-1-0320 Identifying proteomic profiles and biological networks Cynthia C. Morton, PhD of early-stage ovarian cancer Principal Investigator, 2019-2025 Principal Investigator, 2021-2023 • Genetic Hearing Loss Registry Fund • Marsha Rivkin Center for Ovarian Cancer Research Principal Investigator, 2018-2026 Using genetic predictors of CA125 to improve personalized ovarian cancer screening • Orlin Family Research Fund Principal Investigator, 2021-2022 Principal Investigator, 2016-2026 • Brigham and Women’s Hospital - Internal Funds • Kenneth J. Ryan MD Distinguished Chair in OBGYN Identifying early detection metabolomics biomarkers Research Sundry Fund for high-grade serous ovarian cancer - 2020 Sperling Family Fellowship Principal Investigator, 2016-2022 Nicole Smith, MD • NIH 5R01DC015052-05 NCE Subrecipient Principal Investigator, 2021-2022 SEQuencing a baby for an optimal outcome (SEQaBOO) • Massachusetts General Hospital (Taveras) Principal Investigator, 2015-2025 Engaging fathers in the first 1000 days to improve perinatal outcomes • Fund for the genetic screening of newborn hearing Kathryn Terry, PhD Principal Investigator, 2013-2023 Principal Investigator, 2021-2026 • Genetic Support Research Fund • NIH 1R01CA258679-02 Principal Investigator, 2000-2022 Changing contraceptive patterns and ovarian cancer risk • NIH-NIGMS 5P01GM061354-15 NCE Subrecipient Principal Investigator, 2021-2026 DGAP - Developmental Genome Anatomy Project (Administrative Core, Project 1, Project 2) • NIH 5R01CA248288-02 (Goode): Subcontract to Principal Investigator, 1999-2023 Mayo Clinic Relating molecular subgroups of endometriosis- • NIH-NIGMS T32GM007748-43 associated ovarian cancers to survival and risk Training Grant in Genetics 82 Department of Obstetrics and Gynecology

Subrecipient Principal Investigator, 2021-2023 Louise Wilkins-Haug, MD, PhD • NIH 5R01HD094842-05 (Missmer): Subcontract to Subrecipient Principal Investigator, 2021-2025 Michigan State University • NIH 1R01HD105266-01 (Talkowski), MGH Menstrual health during the Covid-19 pandemic: A longitudinal study among young people with and The genomic architecture of pregnancy loss without endometriosis Subrecipient Principal Investigator, 2020-2023 Subrecipient Principal Investigator, 2021-2022 • Boston Children’s Hospital (Orbach) • Marriott Foundation, Boston Children’s Hospital Fetal treatment of galenic malformation Defining the role for descending pain modulation and reward‐aversion processes towards the development Subrecipient Principal Investigator (effective 11/01/21), of chronic pain in endometriosis 2019-2024 Subrecipient Principal Investigator, 2019-2021 • NIH 1R01HD100009-04 (Grant), Boston • NIH 5R01HD089511-05 (Giudice): Subcontract to Children’s Hospital Novel MRI assessment of placental structure and University of California, San Francisco function throughout pregnancy Integrative analysis of genomic, epigenomic and phenotypic data for disease stratification Principal Investigator, 2015-2022 of endometriosis • BWH STORK Award Subrecipient Principal Investigator, 2019-2022 Improved candidate selection for fetal aortic • NIH 5R21HD096358-02 (Missmer): Subcontract to valve dilation Michigan State University Harnessing biomarker and phenotypic diversity among adolescents and women with endometriosis to advance personalized medicine for diagnosis and pain remediation Principal Investigator, 2019-2022 • W81XWH1910318: U.S. Army Research Center Using affinity-based proteomics to identify diagnostic and plasma biomarkers for endometriosis Subrecipient Principal Investigator, 2018-2023 • NIH 5R01HD094842-05 (Fazleabas and Missmer): Subcontract to Michigan State University What is endometriosis? Deep phenotyping to advance diagnosis and treatment Subrecipient Principal Investigator, 2018-2022 • Marriott Foundation, Boston Children’s Hospital Metabolomic signatures of pain and progression among women with endometriosis Research Support 83

Administrative Leadership Administrative Leadership Title Nawal M. Nour, MD, MPH Department Chair Ciera S. Wade Executive Coordinator to the Chair, Annual Report Editor Meredith Wallace, MPH Department Administrator Nicole Rodriguez, MBA Director of Professional Operations, Annual Report Editor Fern Seay Administrative Support Joshua Craft Operations Supervisor Sherry Golden, MA, MSW Executive Assistant, Annual Report Editor Amy Connolly Finance Director Yaziris Lucerna Financial Coordinator Selamawit Mengiste Financial Coordinator Lisa Catalano Senior Manager, Group Practice Management Candace Graham Coding/Compliance Manager Linda Kruse, MPH Academic Manager Falian Pean, MS Ambulatory Administrative Director Betty Simpkins Per Diem Manager Stephanie Eleyi Nurse Director, Ambulatory OB/GYN Isabel Block Nurse Manager, Procedural OB/GYN Laurie Rapson RN Flow Manager, Ambulatory OB/GYN Evelyn Cachecho Senior Administrator, Women’s Health Service Line Corinna Raznikov Annual Report Photographer Susan Symonds Annual Report Photographer Adele Bertschy Annual Report Photographer 84 Department of Obstetrics and Gynecology