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Scope of application Pharmaceuticals and Medicine IPO degree of protection - FS Pharmacopeia article 42-43-0100-2003; - Experimental industrial regulations; - Patent RUz No. 304 - Technical Conditions TSh 88.6-20:2009 Form of transfer rights Lisence agreement Readiness degree of development There is an industrial sample Project implementation Implementation Stages Unparalleled, technology and products can be exported, technology is resource-saving The period of implementation 2020-2022 years Need for additional funding, million sum Funding of 300 million sum is needed. to organize small- scale production on modern equipment. Name of Institute of Bioorganic Chemistry organization Phone number +998 71 262-35-40 [email protected] E-mail 51

Institute of Bioorganic Chemistry named after O.Sodikov ID-24 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Composition for pre-planting Cotton - DAG-1 development Doctor of biological science, Axunov.A.A Author`s name / academic degree Brief description The composition of DAG-1 and P-4 is used in cotton production for pre- planting seed processing in the country's cotton-cleaning plants in order to increase the stability of cotton on salted soils, protect against fungal diseases, as well as improve economic signs and increase yields. Expected results The technology of etching cotton seeds with a new biopesticide will be additionally introduced at the cotton-cleaning plants of the republic. This will improve the quality of cotton seeds by reducing the incidence of phytopathogens; will increase the immune status of cotton due to the activity of the antioxidant system, which will increase the germination of seeds and increase the yield of cotton from 5 to 7 centners per hectare, as well as other indicators that characterize economic and valuable signs; As a result, the effect of the composition content in the seeds will be prolonged, which makes it possible to store the seed material without losing its biological activity. 52

Scope of application Agriculture There are patents of the Republic of Uzbekistan No.IAP 05005 (2015) \"The way to determine the sustainability of cotton varieties to wilt, \" IPO degree of protection No IAP 05090 (2015) \"The way to combat the verticillary withering of cotton.\" Patent Applications: No FAP 20190211 (2019) \"Composition for pre-planting cotton processing\"; No FAP 20190212 (2019) \"Composition for pre-planting cotton processing.\" Form of transfer rights Lisence agreement DAG-1 is included in the List of Chemical and Biological Means of Pest Control, Plant Disease and Weed Disease, Defoliants and Plant Growth Regulators, allowed for use in Readiness degree of development agriculture from 2016 to the present. Toxicological and hygienic report on the drug DAG-1 of the Institute of Sanitation, Hygiene and Occupational Diseases of the Ministry of Health of the Republic of Uzbekistan; Industrial regulations on the preparation of the drug DAG-1; Expert opinion on DAG-1; Economic justification. Project implementation 1. Receiving the drug DAG-1 according to the developed technological conditions; timing - year-round; 2. The use of DAG-1 in the form of composition in conjunction with fungicide P-4 and other fungicides in the etching of cotton seeds in the amount determined in accordance with the agreements with clusters and cotton-cleaning plants of the thilov. Dates - January-February; 3. The etching of cotton seeds from the 2020 harvest at cotton processing plants, with the usual technological conditions in the workshops, is Implementation Stages applied to seed etching by the composition DAG-1-P-4 (the number of seeds for processing is determined in accordance with the contracts with clusters and cotton puring plants). Dates - December-January; 4. The Institute of Bioorganic Chemistry will test the biological activity and effectiveness of seed etching in the laboratory on the basis of an assessment of the antioxidant status of seeds after processing and during storage in warehouses. Dates - February-April The author's supervision in cotton farms clusters and farms. The period of implementation 2021-2022 years Need for additional funding, million sum The project needs 1.5 billion sum. Name of Institute of Bioorganic Chemistry organization Phone number +99871-262-70-73 [email protected] E-mail 53

Institute of Bioorganic Chemistry named after O.Sodikov ID-25 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Pheromone traps against potato moth (Phthorimaea operculella) development Author`s name / academic Candidate of chemical science, Xolbekov.O. degree Candidate of chemical science,Shakirzyanova.G.S Brief description Pheromone traps against potato moths are a bait for male potato moth butterflies and are used to predict their development, distribution and determine the optimal timing of biological or chemical treatment of potato crops or directly against the fight against potato moth. Expected results The implementation of pheromone monitoring contributes to the mass capture of potato moths, as well as the establishment of the timing and the need for quantitative chemical treatments against insect pests, allows keeping cultivated potato crops environmentally friendly. Pheromone traps \"Operkula\" are recommended for use for mass trapping of potato moth in clusters and farms of Uzbekistan 54

Scope of application Clusters and farms of Uzbekistan for growing vegetable crops. IPO degree of protection The pheromone \"Operkula\" is registered in the State Chemical Commission of the Republic of Uzbekistan - Certificate No. 1 А 1753, as a drug, as a pheromone trap of potato moth on vegetable crops at a rate of consumption of 20 pcs / ha. Methodical recommendations on the use of sets of pheromone traps against potato moth \"Operkula\" were approved by the working body under the State Chemical Commission of the Cabinet of Ministers of the Republic of Uzbekistan. Form of transfer rights Lisence agreement Readiness degree of development Approved \"Laboratory regulations\" for the production of tomato moth pheromone - Trans-4, cis-7, cis-10- tridecatrienyl acetate from the corresponding alcohol. Laboratory and field tests of the potato moth pheromone trap were carried out on the cultivated areas of potatoes. The preparative dose of pheromone was determined. The results obtained are not inferior to imported analogs. Project implementation Implementation Stages 1. Providing proposals for the purchase of chemical The period of implementation reagents for the synthesis and accumulation of pheromone of the potato moth. - 2021 2. Development of technical specifications for the Organization Standard for pheromone traps \"Operkula\", regulatory documents - Organization Standard for pheromone traps \"Operkula\" -2021 - 2022 3. Completion and implementation of pheromone traps against potato moth –2021-2022. 4. Author's supervision over the process of pheromonitoring against the pest of potato crops - potato moth in order to control their efficiency at various stages of growth and development of potatoes in clusters and farms. 2021-2022 years Need for additional funding, million sum 500.0 million sum for the creation of industrial infrastructure Name of Institute of Bioorganic Chemistry organization Phone number +99871 235 0344 [email protected] E-mail 55

Institute of Bioorganic Chemistry named after O.Sodikov ID-26 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Drug Rutan, which has antiviral action development Author`s name / academic Doctor of chemical science, prof – Abdullajanova.N.G degree Brief description For the first time, the original drug Rutan, which has a vaccine against influenza virus and coronavirus, was created on the basis of local plant raw materials from the above-ground part of Rhus coriaria L. The drug is effective against various strains of influenza virus, as well as against coronavirus SARS COV-2. Expected results 1. Development of the technological regulation of substance production, organization of the production of an experimental batch of substance and medicinal form - 2021. 2. Providing clarified proposals for the purchase and manufacture of equipment - 2021 3.Preparing regulatory documentation, participating in the launch and setting up of the technology line - 2021 4. Author's Oversight of Technological Processes - 2022 Social value - ensuring the medicinal independence of the country. 56

Scope of application Pharmaceuticals and Medicine The development is protected by the patent of RUz. IPO degree of protection Patent UZ. No. IAR 04524 of 31.07.2012 \"A means of having an anti-flu effect.\" Form of transfer rights Lisence agreement Readiness degree of development Rutan tablets are allowed to be used in medical practice. Project implementation Production of the substance and drug form will be Implementation Stages established on the experimental basis of the Institute of Bioorganic Chemistry. The period of implementation 2020-2022 years Need for additional funding, million sum 1 billion sum for the creation of industrial infrastructure Name of Institute of Bioorganic Chemistry organization Phone number +998 99 5131873 [email protected] E-mail 57

Institute of Bioorganic Chemistry named after O.Sodikov ID-27 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Gossitan - anti-flu-action drug development Author`s name / academic Doctor of chemical science, prof – Abdullajanova.N.G degree Brief description The original drug Gossitan is created on the basis of polyphenol compounds of local plant raw materials. Gossitan is excreted from the leaves of the plant Gossypium hirsutum L. Preperate is effective against different strains of influenza virus. The drug is more effective than the interferoninducing and antiviral drugs used in modern medicine. Induces the production of late α, β-, interferons, which have high antiviral activity and exhibit direct virulicide. Expected results 1. Development of the technological regulation of substance production, organization of the production of an experimental batch of substance and medicinal form - 2021. 2. Providing clarified proposals for the purchase and manufacture of equipment - 2021 3.Preparing regulatory documentation, participating in the launch and setting up of the technology line - 2021 4. Author's Oversight of Technological Processes - 2022 Social value - ensuring the medicinal independence of the country. 58

Scope of application Pharmaceuticals and Medicine The development is protected by the patent of Rv. IPO degree of protection The drug is protected by the RUz Patent: U.S. No. \"A means of influenza effect.\" 31.07. 2012. Form of transfer rights Lisence agreement Readiness degree of development The set of regulatory documents has been submitted to the General Office of Drug Quality Control and Medical Techniques of the Ministry of Health. Granted of clinical trials Project implementation Production of the substance and drug form will be Implementation Stages established on the experimental basis of the Institute of Bioorganic Chemistry. The period of implementation 2020-2022 years Need for additional funding, million sum 1 billion sum for the creation of industrial infrastructure Name of Institute of Bioorganic Chemistry organization Phone number +998 99 5131873 [email protected] E-mail 59

Institute of Bioorganic Chemistry named after O.Sodikov ID-28 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Getasan, Punitan Anti-HIV Drugs development Author`s name / academic Doctor of chemical science, prof – Abdullajanova.N.G degree Brief description Getasan is excreted from geranium sanguineum leaves, Punica granatum fruit peel. Original drugs Getasan, Punitan based on natural polyphenol complexes, have anti-HIV activity. Drugs induce the production of their own interferon and show direct virulicide, bactericides against gonococcals, trihomonad, enterobacteria, non- enzyme gram-negative bacteria, staphylococcus, streptococcus, yeast- like fungi of the genus Candiola. Expected results 1. Development of the technological regulation of substance production, organization of the production of an experimental batch of substance and medicinal form - 2021. 2. Providing clarified proposals for the purchase and manufacture of equipment - 2021 3.Preparing regulatory documentation, participating in the launch and setting up of the technology line - 2021 4. Author's Oversight of Technological Processes - 2022 Social value - ensuring the medicinal independence of the country. 60

Scope of application Pharmaceuticals and Medicine IPO degree of protection The development is protected by RUz patents. The drug Punitan is protected by the Patent of RUz : U.A.A.A. 04523 \"An anti-HIV activity agent.\" The drug Getasan is protected by the Patent of RUz : Patent of U No. IAR 04523 of 31.07. 2012. \"An anti-HIV-activity tool.\" Form of transfer rights Lisence agreement Readiness degree of development The regulatory documentation set has been transferred to the General Office of Drug and Medical Technology Control of the Ministry of Health. Permission has been obtained for clinical trials based on the Republican Center for AIDS Control of the Ministry of AIDS. The regulatory documentation of the drug Punitan has been submitted to the Pharmacopeia Committee for approval for clinical trials. Project implementation Production of the substance and drug form will be Implementation Stages established on the experimental basis of the Institute of Bioorganic Chemistry. The period of implementation 2020-2022 years Need for additional funding, million sum 1 billion sum to build production infrastructure Name of Institute of Bioorganic Chemistry organization Phone number +998 99 5131873 [email protected] E-mail 61

Institute of Bioorganic Chemistry named after O.Sodikov ID-29 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Drug Euphorbin, which has anti-HIV activity development Author`s name / academic Doctor of chemical science, prof – Abdullajanova.N.G degree Brief description For the first time, the original drug Euphorbin, which has anti-HIV Expected results activity, was created on the basis of local plant materials from the underground part of Euphorbia ferganensis B.Fedtch Euphorbin at 10 micrograms/ml suppresses HIV-1 replication by more than 80%. Euphorbin is non-toxic, has no cumulative effect, has no toxic effect on peripheral blood, kidney and liver function, as well as on the pathomorphology of organs and tissues, does not have embryotoxic and teratogenic action. 1. Development of the technological regulation of substance production, organization of the production of an experimental batch of substance and medicinal form - 2021. 2. Providing clarified proposals for the purchase and manufacture of equipment - 2021 3.Preparing regulatory documentation, participating in the launch and setting up of the technology line - 2021 4. Author's Oversight of Technological Processes - 2022 62

Scope of application Pharmaceuticals and Medicine The development is protected by RUz patents. IPO degree of protection The drug is protected by the Patent of RUse : Patent of U.I.A. 04666 of 31.07. 2012. \"An anti-HIV-activity tool.\" Form of transfer rights Lisence agreement Readiness degree of development The regulatory documentation of the drug Euforbin has been submitted to the Pharmacopeia Committee for approval for clinical trials. Project implementation Production of the substance and drug form will be Implementation Stages established on the experimental basis of the Institute of Bioorganic Chemistry. The period of implementation 2020-2022 years Need for additional funding, million sum 1 billion sum for the creation of industrial infrastructure Name of Institute of Bioorganic Chemistry organization Phone number +998 99 5131873 [email protected] E-mail 63

Institute of Bioorganic Chemistry named after O.Sodikov ID-30 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Antidiabetic – Plantagin development Author`s name / academic Doctor of chemical science, prof – Abdullajanova.N.G degree Brief description The composition of polyphenol compounds from the plant Plantago major L. (Plantagin) showing hypoglycemic activity on various models of hyperglycemia, has stronger antioxidant properties (has a more pronounced compared to the used in medicine glyclaside, glybenc hilarious), preventing the development of complications of diabetes. Expected results 1. Development of the technological regulation of substance production, organization of the production of an experimental batch of substance and medicinal form - 2021. 2. Providing clarified proposals for the purchase and manufacture of equipment - 2021 3.Preparing regulatory documentation, participating in the launch and setting up of the technology line - 2021 4. Author's Oversight of Technological Processes - 2022 64

Scope of application Pharmaceuticals and Medicine The development is protected by RUz patents. IPO degree of protection The drug is protected by the Patent of RUz : IAP 06027 from 08.10.2019. \"Antidiabetic remedy.\" Form of transfer rights Lisence agreement Readiness degree of development A set of regulatory documentation of the plantagin drug has been prepared for transfer to the Pharmacopeia Committee for approval for clinical trials. Project implementation Production of the substance and drug form will be Implementation Stages established on the experimental basis of the Institute of Bioorganic Chemistry. The period of implementation 2020-2022 years Need for additional funding, million sum 1 billion sum for the creation of industrial infrastructure Name of Institute of Bioorganic Chemistry organization Phone number +998 99 5131873 [email protected] E-mail 65

Institute of Bioorganic Chemistry named after O.Sodikov ID-31 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Providine - antihypoxic drug development Author`s name / academic Doctor of chemical science, prof – Abdullajanova.N.G degree Brief description The drug Providine is created on the basis of polyphenol compounds of the plant Vitis vinivera L. Providine is used to prevent and treat hypoxic conditions, cardiovascular diseases. Providine on models of hypoxic hypobaric hypoxia, normobaric and cytotoxic hypoxia is not inferior to foreign counterparts. In addition, it is a promising compound for introduction into medicine as a hypocholesteromin and antisclerotic drug for the prevention and treatment of patients with atherosclerosis, has a protective and membrane-stabilizing actions, normalizes the indicators, triglycerides in the serum; reduces low-density lipoprotein cholesterol, but increases high-density lipoprotein cholesterol. Expected results 1. Development of the technological regulation of substance production, organization of the production of an experimental batch of substance and medicinal form - 2021. 2. Providing clarified proposals for the purchase and manufacture of equipment - 2021 3.Preparing regulatory documentation, participating in the launch and setting up of the technology line - 2021 4. Author's Oversight of Technological Processes - 2022 66

Scope of application Pharmaceuticals and Medicine The development is protected by RUz patents. IPO degree of protection The drug is protected by the Patent of U.S. No. № IAP 2010 0477 от 18.06.2012. \"An anti-hypoxic activity\" Form of transfer rights Lisence agreement Readiness degree of development A set of regulatory documentation of the plantagin drug has been prepared for transfer to the Pharmacopeia Committee for approval for clinical trials. Project implementation Production of the substance and drug form will be Implementation Stages established on the experimental basis of the Institute of Bioorganic Chemistry. The period of implementation 2020-2022 years Need for additional funding, million sum 1 billion sum for the creation of industrial infrastructure Name of Institute of Bioorganic Chemistry organization Phone number +998 99 5131873 [email protected] E-mail 67

Institute of Bioorganic Chemistry named after O.Sodikov ID-32 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Pheromone traps against tomato moth (Tuta absoluta) development Author`s name / academic Candidate of chemical science, Xolbekov.O. degree Candidate of chemical science,Shakirzyanova.G.S Brief description Pheromone traps against tomato moth are bait for male tomato moth butterflies and are used to predict their development, distribution and determine the optimal timing of biological or chemical treatment of tomato crops or directly with tomato moth. Expected results The implementation of pheromone monitoring contributes to the mass capture of tomato moth, as well as the establishment of the timing and the need for quantitative chemical treatments against insect pests, allows you to keep grown tomato crops environmentally friendly. Pheromone traps \"Absolute\" are recommended for use for mass trapping of tomato moth in clusters and farms of Uzbekistan 68

Scope of application Clusters and farms of Uzbekistan for growing vegetable crops. IPO degree of protection The pheromone \"Absolute\" is registered in the State Chemical Commission of the Republic of Uzbekistan - Certificate No. 1 A 1752, as a drug, as a pheromone trap for tomato mining moth on tomatoes at a consumption rate of 20 pcs / ha Methodological recommendations on the use of sets of pheromone traps against tomato moth \"Absolute\" were approved by the working body under the State Chemical Commission of the Cabinet of Ministers of the Republic of Uzbekistan. Form of transfer rights Lisence agreement Readiness degree of development Approved \"Laboratory regulations\" for the production of tomato moth pheromone - Trans-3, cis-8, cis-11- tetradecatrienyl acetate from the corresponding alcohol. Laboratory and field tests of the tomato moth pheromone trap were carried out on the sown areas of tomatoes. The preparative dose of pheromone was determined. The results obtained are not inferior to imported analogs. Project implementation Implementation Stages 1. Submission of proposals for the purchase of chemicals for The period of implementation the synthesis and accumulation of pheromone in tomato moth. - 2021 2. Development of technical specifications for the Organization Standard for pheromone traps \"Absolute\", regulatory documents - Organization Standard for pheromone traps \"Absolute\" - 2021 - 2022 3. Completion and implementation of pheromone traps against tomato moth –2021-2022. 4. Author's supervision over the process of pheromonitoring against the pest of tomato crops - tomato moth in order to control their efficiency at various stages of growth and development of tomatoes in clusters and farms. 2021-2022 years Need for additional funding, million sum 500.0 million sum for the creation of industrial infrastructure Name of Institute of Bioorganic Chemistry organization Phone number +998 99 5131873 [email protected] E-mail 69

Institute of Bioorganic Chemistry named after O.Sodikov ID-33 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / The combined preparation \"Fludigel\" development Author`s name / academic Academic Turayev.A.S , Filatova.A.V degree Brief description Combined external drug \"Fludigel\", which includes antiallergic drug diphenhydramine, antifungal drug fluconazole, anti-inflammatory drug dimethyl sulfoxide. The drug has a combined effect, being an antiallergic, antifungal and anti-inflammatory drug, due to the combination and synergism of the action of the active components of the drug. The drug is planned to be used against allergies complicated by a fungal infection - contact and atopic dermatitis, mycoses of the head and neck, skin candidiasis, itching, insect bites. Expected results The production of the drug will allow replacing the combined hormonal drugs \"Triderm\", \"Lorinden gel\" and antiallergic gels, which are in high demand due to the widespread prevalence of skin diseases and are expensive external drugs. 70

Scope of application Healthcare and pharmaceuticals. The gel can be used in dermatology. Patent No. IAP 05327 dated January 18, 2017. A gel with IPO degree of protection antiallergic, antifungal, immunomodulatory and anesthetic effects. Form of transfer rights Lisence agreement Readiness degree of development Developed laboratory technological regulations for production. VFS project developed Project implementation Transfer of NTD to the Pharmaceutical Committee to obtain Implementation Stages permission for clinical trials. Clinical trials. The period of implementation 2021-2022 years Need for additional funding, million sum 400.0 million sum for the creation of industrial infrastructure Name of Institute of Bioorganic Chemistry organization Phone number +99871 2623540 [email protected] E-mail 71

Institute of Bioorganic Chemistry named after O.Sodikov ID-34 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / \"Mixture 0.001%\" - a drug for the treatment of anemia development Author`s name / academic Candidate of chemical science- Gafurova.N.D degree Brief description Eritim is a complex of proteins and peptides isolated from the mammalian thymus. The main property of Eritim is a rapid increase in the level of hemoglobin, the number of erythrocytes and the normalization of hematocrit. The indication for the use of the drug is iron deficiency in women. Eritim can be used as part of complex therapy. The main advantages of Eritim in comparison with the best foreign drugs for the treatment of anemia and not containing iron are: 1. The drug should be 50-400 times less. 2. Eritim is 100-1000 times cheaper. 3. The duration of treatment is 4-8 times shorter. Eritim is obtained entirely from local raw materials from the organs of farm animals. The release of the drug Eritim will make it possible to effectively treat anemia in Uzbekistan, reduce the import of expensive foreign drugs and export it to the CIS countries. The drug Eritim is registered in the Pharmaceutical Committee of the Expected results Ministry of Health of the Republic of Uzbekistan and permission for its production has been obtained. 72

Scope of application Pharmaseutical and Medicine Patent RUz No. IAP 05258 dated 15.08.2016 was received IPO degree of protection for \"Method for producing immunostimulating thymic polypeptides affecting hematopoiesis\". Form of transfer rights Lisence agreement Readiness degree of development Eritim passed full clinical trials in three basic clinics of the Ministry of Health of the Republic of Uzbekistan and received permission to use the drug in medical practice. Project implementation Implementation Stages Cooperation in the sale of finished products with medical institutions and pharmacies. The period of implementation 2021-2023 years Need for additional funding, million sum The need for financing is 200 million sum. Of these, 120 million sum for the purchase of equipment and preparation of production facilities; 80 million sum for the establishment of production and advertising of Eritim. Name of Institute of Bioorganic Chemistry organization Phone number +99871 262-35-40 [email protected] E-mail 73

Institute of Ion-plasma and laser technologies ID-35 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Technology and equipment for vacuum freeze drying of products development (Vacuum Lyophilizer/Vacuum Freeze Dryer) Author`s name / academic Dr. Ashurov Kh.B. degree Brief description Freeze-drying is based on the ability of ice to evaporate under certain conditions, by passing the liquid phase. When freeze-dried, the product retains almost all of its taste. In this case, the finished product is stored for a long time at positive temperatures, which eliminates the need for refrigerated storage. Significantly reduced product weight after drying, lower handling and transport costs. Creation of an industrial plant for the implementation of freeze drying Expected results for agricultural products, biological additives, food semi-finished products 74

Scope of application Agriculture, biology, pharmaceuticals IPO degree of protection Protection of technology and equipment is on process Form of transfer rights Manufacturing of equipment Readiness degree of development The technology is ready for implementation. There is a prototype. Project implementation Implementation Stages The installation is implemented at the Institute of Microbiology for drying biologically active substances The period of implementation 2020-2021 Need for additional funding, million sum 1 500.0 million UZS to create infrastructure for the production of equipment Name of Институт Ионно плазменных и лазерных технологий АН РУз organization Phone number +998 977087264 [email protected] E-mail 75

Institute оf Mechanics аnd Seismic Stability оf Structures named after M.T.Urazbaev ID-36 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Multi-operation machine for machining semi-finished leather goods development Author`s name / academic M.I.Nosirov degree Brief description The developed multioperational machine makes it possible to carry out several technological operations of mechanical processing of semi- finished leather in a sequence. The technological machine will provide high efficiency in energy and resource saving. An industrial prototype of a multi-operation machine for mechanical Expected results processing of semi-finished leather will be made and submitted for testing to the enterprises of the Uzcharmsanoat association. 76

Scope of application Leather and fur industry The patent of the Republic of Uzbekistan No. FAP 00675 IPO degree of protection “Machine for mechanical processing of leather” from 2010 was received. Form of transfer rights License agreement (contract). Readiness degree of development A complex of scientific and technical documentation for the developed multi-operation machine for mechanical processing of semi-finished leather has been prepared. Project implementation Laboratory regulations have been prepared for the working Implementation Stages bodies of a multi-operation machine for mechanical processing of semi-finished leather. The period of implementation 2021 y. Need for additional funding, million sum 1000 million soums (The total amount may vary depending on customer requirements). Name of Institute оf Mechanics аnd Seismic Stability оf Structures organization Phone number +998 99 807 88 16 [email protected] E-mail 77

Institute оf Mechanics аnd Seismic Stability оf Structures named after M.T.Urazbaev ID-37 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Gear-lever differential transmission mechanism(GLDTM) of which the development rotational centers of the working shafts are symmetrical moving Author`s name / academic Madaminov S.M. degree The project aims to increase the working efficiency of symmetrical Brief description moving roller machines with rotating centers of working shafts used in the tanning industry and improve the quality of the processed product. Expected results By applying the design on roller machines, it serves to increase the life of the working shafts and their coatings. It was found experimentally that using the project increased the life of the working shafts and their coating by 1.4 times. By applying the design to production, it is possible to reduce the cost of replacing working shafts and their coating by 40%. 78

Scope of application The project aims to increase the working efficiency of symmetrical moving roller machines with rotating centers of working shafts used in the tanning industry and improve the quality of the processed product. IPO degree of protection № IAP 04934 Gear transmission mechanisms of mechines which has a shaft (options)15.07.2014y. Form of transfer rights License agreement (contract). Readiness degree of development There is research work on the development and a moving experimental test prototype. Project implementation Implementation Stages 1. Development of terms of reference for the preparation of GLDTM - term: 2021 y. I-quarter. 2. Preparation of technical documentation for the preparation of GLDTM - term: 2021. II quarter. 3. Preparation and assembly of GLDTM working parts - term: 2021 y. II quarter. 4. Experimental testing of GLDTM - term: 2021 y. IV quarter. The period of implementation 2021y Need for additional funding, million sum 1000 mln sum. (The amount can vary depending on the customer's requirements) Name of Institute оf Mechanics аnd Seismic Stability оf Structures organization Phone number +998 97 358 68 00 [email protected] E-mail 79

Institute of Plant Chemistry named after S.Yu.Yunusov. ID-38 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Pure magnesium sulfate heptahydrate in terms of pharmacopoeia development based on local raw materials Author`s name / academic Cand. Chem.sciences, senior researcher A.Sh. Abdurazakov degree Brief description PP-3489 of January 23, 2018 \"On measures to further simplify the Expected results production and import of medicines and medical devices\" and PP-5229 of November 7, 2017 of the President of the Republic of Uzbekistan \"On the management system of the pharmaceutical industry\" The resolution \"On measures for radical improvement\", as well as the creation of medicines from local raw materials in order to create favorable conditions for increasing the volume of production and competitiveness of local pharmaceutical products is of great importance. The project is aimed at creating a technology for the production of pharmacologically pure magnesium sulfate heptahydrate from technical magnesium sulfate at JSC \"Maksam-Chirchik\" TSh 6.3-89: 2009. As a result of the project, the technology of extraction of magnesium sulfate heptahydrate from local raw materials will be developed. is prepared for registration 80

Scope of application Chemical, medical industry IPO degree of protection The patent is pending Form of transfer rights License Agreement Readiness degree of development In terms of pharmacopoeia, draft VFS, TI and laboratory- technological regulations for the production of pure magnesium sulfate heptahydrate have been prepared. Experimental batches of pure magnesium sulfate heptahydrate in the amount of 5 kg were developed at the GMP Institute of Chemistry of the Academy of Sciences of the Republic of Uzbekistan. The obtained magnesium sulfate was analyzed for purity of heptahydrate and found to meet the requirements for a medical product in terms of physicochemical parameters. Project implementation Implementation Stages 1. Pharmacopoeia Study of pure magnesium sulfate heptahydrate bioequivalence – 2020 2. Participation in the preparation of regulatory and technical documents, commissioning and adjustment of the production line – 2021 3. Carrying out field control of technological processes – 2021 The period of implementation 2020-2021 Need for additional funding, million sum 500.0 million for the creation of industrial infrastructure Name of Institute of Plant Chemistry organization Phone number +99871-2625913 [email protected] E-mail 81

Institute of Plant Chemistry named after S.Yu.Yunusov ID-39 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Drug for veterinary medicine development Author`s name / academic Candidate of Chemical Sciences, Senior Research Fellow degree A.Sh. Abdurazakov Brief description A polymer form of albendazole with low toxicity and increased anthelmintic activity has been developed. An optimal composition has been developed for the stable suspension form of albendazole. Laboratory samples of the albendazole (Alsus) suspension have yielded positive results in biological studies on animals (Uz NIVI 2018 report). Expected results Imports of anthelmintic drugs for veterinary medicine are reduced 82

Scope of application Chemistry, medical industry, veterinary medicine 1 patent of Uzbekistan was obtained (Patent IAP 05331), 2 IPO degree of protection patent applications were filed (№ IAP 20170374 and № IAP 20170209) Form of transfer rights License Agreement Readiness degree of development Modified anthelmintic drugs with increased physiological activity are offered. All documents for the production of Alsus were prepared. Developed at the Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan and sold 100 liters of albendazole suspension (Alsus). Project implementation Implementation Stages - The period of implementation 2021-2022 Need for additional funding, million sum - Name of Institute of Plant Chemistry organization Phone number +99871-2625913 [email protected] E-mail 83

Institute of Material Sciences, Turin Polytechnic University in Tashkent ID-40 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Method of obtaining technical oleic acid development Author`s name / academic Mamatkulov Sh.I., PhD degree Parpiev O.R., PhD Butanov H.T., PhD Mamanazirov J.I. Researcher Ruzimuradov O.N., DS Brief description Obtaining technical oleic acid. The production of technical oleic acid will be focused on the domestic market of Uzbekistan. A technology for producing oleic acid from industrial vegetable oils Expected results (cottonseed, sunflower, safflower, rapeseed) of various degrees of purification will be developed. 84

Scope of application Oleic acid is used in medicine, cosmetology, metalworking and in the production of rubber products. In particular, oleic acid is used in the food industry in the production of flavorings, in the cellulose and paper industry - as a cellulose plasticizer. Unsaturated acids are widely used in metalworking, especially as a cutting fluid in metal cutting operations, as well as in the mining industry. IPO degree of protection Notification from the Intellectual Property Agency under the Ministry of Justice of the Republic of Uzbekistan for a patent for an invention. No. IAP 2020 0336 dated 08/10/2020 Form of transfer rights License agreement Readiness degree of development Laboratory and semi-industrial tests have been carried out. The technology is made in accordance with the regulatory requirements for an invention at the Intellectual Property Agency under the Ministry of Justice of the Republic of Uzbekistan. An invention patent application has been filed. The results obtained are not inferior to imported analogues. Project implementation Implementation Stages A semi-industrial test was carried out at JSC \"Almalyk MMC\". The period of implementation 2021-2022 Need for additional funding, million sum 2,000.0 million sums are necessary to create an industrial line for the production of technical oleic acid. Name of Institute of Material Sciences organization Turin Polytechnic University in Tashkent, Phone number +99870 722-53-00 E-mail [email protected] 85

Institute of Material Sciences ID-41 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Film-ceramic composite based on functional ceramics and development polyethylene film Author`s name / academic Rakhimov R.H., DS degree Ermakov V.P., Researcher Rakhimov M.P., Researcher Latipov R.N., Engineer Brief description The offered film-ceramic composites are intended for: - stabilization of temperature in greenhouses, activation of plant phytochrome to accelerate growth and increase yields, to maintain temperature in residential and non-residential premises without additional energy consumption. The long-term large-scale tests carried out have shown that the real fuel economy is 40-60%, the yield increases by 30-50%. - for high quality drying of agricultural products. By transforming the spectrum of solar radiation into the optimal one, the drying time is reduced by 3-6 times, vitamins and other active substances are fully preserved. Expected results Resource and energy saving for proper facilities use, improvement of the quality of target products, simplicity of use. 86

Scope of application Agriculture, temperature stabilization in residential and non- residential premises, construction, household use. IPO degree of protection Patent of the Republic of Uzbekistan # IAP 04844 dated 26.02.2014, as well as know-how. Form of transfer rights Joint production Readiness degree of development The composite has passed large-scale tests in Uzbekistan, Germany, Belarus, Kyrgyzstan, Russia; a pilot batch was released by the Jizzakh plant of plastic products Project implementation Implementation Stages Implementation in relevant industries 2021-2025 The period of implementation 2021-2022 Need for additional funding, million sum 8,500.0 million sums for the purchase of equipment for the large-scale production of functional ceramics Name of Institute of Material Sciences organization Phone number +99899 803-24-68 [email protected] E-mail 87

Institute of Seismology ID-42 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Indicator of seismic impact intensity development Author`s name / academic A.Kh.Ibragimov, A.Li degree Brief description During earthquakes, the indicator shows the intensity in the scores on the scale EMS-98 Expected results Operational determination of seismic impact intensity 88

Scope of application Dams of reservoirs, high-rise buildings, Especially important objects of the national economy IPO degree of protection Patenting of the device is underway Form of transfer rights license agreement Readiness degree of development The device is fully ready Project implementation Implementation Stages - The period of implementation - Need for additional funding, million sum No additional funding is required Name of Institute of seismology organization Phone number +99890 3176333 [email protected] E-mail 89

Institute of Seismology ID-43 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / «SeismicRiskAssessment» - software for forecasting of direct damage development from a major earthquake Author`s name / academic Ismailov V.A. - Doctor of Geological and Mineralogical Sciences. degree Yodgorov Sh.I. - Doctor of Philosophy (PhD) in Geological and Mineralogical Science. Aktamov B.U. - Junior researcher. Sadirov F.X. - Junior researcher. Matvapayev S.R. - Junior researcher. Brief description Software allows to allocate macroseismic zones with different intensities, to assess seismic vulnerability and damage of different types of buildings and constructions and to calculate the economic loss in case of a strong earthquake of a regional scale. Expected results Direct economic loss in case of strong earthquake will be assessed. Development of preventive measures to reduce the impact of a strong earthquake and preparation of emergency-rescue actions in case of strong earthquake. 90

Scope of application Seismic safety of the population and the territory of the Republic of Uzbekistan IPO degree of protection Registered in the Intellectual Property Agency under the Ministry of Justice of the Republic of Uzbekistan for the developed software package \"SeismicRiskAssessment\". DGU 2020 1582, 22.09.2020 г. Form of transfer rights License agreement Readiness degree of development - The developed software package \"SeismicRiskAssessment\" is characterized by reliability, simple interface and has been implemented in accordance with the regulatory requirements for software in the Agency for Intellectual Property under the Ministry of Justice of the Republic of Uzbekistan. - A laboratory standard has been prepared. - Tests have been carried out in laboratory conditions. - The results obtained are as good as those obtained by imported analogues. Project implementation Implementation Stages The Ministry of Emergency Situations of RUz has been introduced (may be used by local authorities). The period of implementation 2021-2022 y. Need for additional funding, million sum 1,500.0 million UZS to create regional infrastructure databases. Name of Institute of Seismology organization Phone number +99871 241-74-98 [email protected] E-mail 91

Physical-Technical Institute ID-44 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Optical power meter for diagnostics of fiber-optic communication lines development Author`s name / academic Dr. Giyasova F.A. degree Brief description The device allows diagnosing the degree of mechanical damages in fiber-optic communication lines and determining the degree of signal attenuation, as well as measuring the voltage, resistance and current in electrical circuits. Expected results The optical power meter and multimeter is designed to measure optical power in a optical fiber in the spectral ranges of 1310 and 1550 nm, measure attenuation degree and continuity of connecting optical cables, as well as measure voltage, resistance and current in electrical circuits. The device will allow easy and quick way to assess the state of fiber-optic communication lines, to find damaged or worn out areas of optical fiber cables. 92

Scope of application In all industries where fiber-optic data transmission systems are widely used. IPO degree of protection Filed an application for a patent for utility model. Form of transfer rights License agreement Readiness degree of development A laboratory sample has been prepared. Tests carried out in laboratory conditions. The results obtained are not inferior to imported analogues. Project implementation Implementation Stages - The period of implementation - Need for additional funding, million sum - Name of Physical-Technical Institute organization Phone number +998-71-2331271 [email protected] E-mail 93

Physical-Technical Institute ID-45 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Photoelectric colorimeter for reagent-free assessment of bilirubin in development blood plasma Author`s name / academic Dr. Kabulov R.R. degree Dr. Tursumetov A.A. S.Yu.Gerasimenko Brief description The mobile device allows to quantitatively determine the level of total bilirubin in blood plasma using a reagent-free method. Expected results It will make it possible to pre-diagnose the functionality and efficiency of the patients liver in ordinary polyclinics and mobile laboratories. 94

In polyclinics and other medical institutions, as well as Scope of application mobile laboratories of the Ministry of Health of the Republic of Uzbekistan. IPO degree of protection The intellectual property is protected by a certificate for the software product of the Agency for Intellectual Property under the Ministry of Justice of the Republic of Uzbekistan \"Software product for transmitting data from a microcontroller of a device for assessing the level of bilirubin in blood plasma and processing them on a computer.\" Form of transfer rights License agreement Readiness degree of development A laboratory sample has been prepared. Tests carried out in laboratory conditions. The results obtained are not inferior to imported analogues. Project implementation Implementation Stages Test studies are being conducted The period of implementation 2021-2022 Need for additional funding, million sum 800.0 million soms to create a database of liver diseases Name of Physical-Technical Institute organization Phone number +998-71-2331271 [email protected] E-mail 95

Physical-Technical Institute ID-46 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Flame control device for gas burners based on an ultraviolet sensor development Author`s name / academic Dr. Kabulov R.R. degree Gerasimenko S.Yu. Brief description The mobile device allows to control the combustion of natural gas with protection against emergency situations. Expected results Will make it possible to avoid various man-made disasters associated with an uncontrolled explosion of natural gas 96

Ministry of Emergency Situations of Republic of Uzbekistan, Scope of application Oil and Gas Industry, natural gas consumers (boiler houses and private sector) IPO degree of protection Filed an application for a patent for utility model. Form of transfer rights License agreement Readiness degree of development A laboratory sample has been prepared. Tests carried out in laboratory conditions. The results obtained are not inferior to imported analogues. Project implementation Implementation Stages Test studies are being conducted The period of implementation 2021-2022 Need for additional funding, million sum 800.0 million soms for test studies on high-power gas boiler houses Name of Physical-Technical Institute organization Phone number +998-71-2331271 [email protected] E-mail 97

Institute of Nuclear Physics ID-47 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Antibacterial medical masks modified by silver nanoparticles development Author`s name / academic Khaydarov R.R., PhD degree Brief description In 2020 the technology for bacteriostatic treatment of medical masks with a solution of silver nanoparticles was developed at the INP AS RU. Tests conducted in certified laboratories have revealed that the created technology creates a reliable barrier for the prevention of infections with pathogens. Expected results The developed technology helps to guarantee the absence of pathogenic microbes on medical masks, even with repeated use. 98

Scope of application Consumer goods IPO degree of protection Patent, technical specifications approved by \"Uzstandard\" agency. Form of transfer rights License agreement Readiness degree of development The technological process has been worked out, a pilot batch has been manufactured. Investments are needed to launch serial production. Project implementation Implementation Stages Neediness for external funding for the development and manufacture of a device for automatic processing of a meltblown (intermediate filtering layer of medical masks) with silver nanoparticles synthesized at INP AN RU, and for purchasing materials for the production of the first batch of masks. The period of implementation 2021-2022 Need for additional funding, million sum 1200 million sums Name of Institute of Nuclear Physics organization Phone number +99871 289-31-44 [email protected] E-mail 99

Institute of Nuclear Physics ID-48 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Baromembrane water desalination system (500 l / h) development Author`s name / academic Khaydarov R.R., PhD degree Brief description In 2020 a baromembrane water desalination system with a capacity of up to 500 l / h has been developed in the INP AS RU. The system uses a novel innovative antiscalant composition and can be operated using solar batteries as an energy source. Expected results The developed system can help providing the population of rural and distant from the central water supply regions with high-quality drinking water. It can also significantly reduce the costs of using reverse osmosis treatment systems in various areas of the industry of the Republic of Uzbekistan. 100