CSIR Technologies for COVID-19 Mitigation_1

CSIR Technologies for COVID-19 Mitigation Council of Scientific and Industrial Research

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CSIR Technologies for COVID-19 Mitigation Council of Scientific and Industrial Research RAFI MARG, NEW DELHI – 110 001 i

CSIR Technologies for COVID-19 Mitigation July 2020 Formatting & Designing Neeru Vijan, Sarla Dutta and Abhinav Raj Production Neelu Srivastav and Ashwani Brahmi Designed and Printed by CSIR-National Institute of Science Communication and Information Resources (CSIR-NISCAIR) Vigyan Sanchar Bhawan, New Delhi ii

Foreword The COVID-19 pandemic has brought the world literally to a standstill. There is still no cure or a vaccine for this highly infectious disease. The WHO declared COVID-19 as a pandemic on 11 March 2020 and ever since, scientists all over the world have been in pursuit of a cure or a vaccine and have been developing technologies to combat this pandemic. CSIR, through its 38 laboratories and expertise in diverse areas ranging from aerospace to buildings to genomics to chemicals, quickly sprang into action developing COVID-19 interventions. For effective planning and strategizing, CSIR swiftly set up five COVID-19 verticals including disease surveillance, drugs & vaccines, testing & diagnostics, PPEs and supply chain management. CSIR's rich R&D knowledgebase is embodied in the rapid testing, cost-effective diagnostic kits, virus culture, genome sequencing and disease surveillance. With the perfect blend of scientific knowledge, technical expertise, industry linkages and governmental interfaces, in about 100 days CSIR has come up with almost as many technologies and products to be deployed against COVID-19. From innovations and improvisations, these technologies have different levels of sophistication. Right from ventilators to indigenous diagnostic kits to clinical trials of repurposed drugs to much needed WHO stipulated hand sanitizers and masks, CSIR has been at the forefront in the nation's crusade against COVID-19. CSIR has developed direct RT-PCR method and novel FELUDA diagnostic kit for COVID-19. When the country faced a shortage of PPEs, CSIR developed a protective coverall and today coveralls are being manufactured in the thousands. CSIR developed a ventilator in a record 36 days. Even the mundane but must-adorn mask underwent various kinds of innovations in terms of the materials woven or the coatings layered in them. About 60 out of the 100 or so technologies listed in this compendium have already been transferred to industry partners. The COVID-19 technologies are licensed on a non-exclusive basis and it is heart-warming that all our industrial partners have been quick to respond and engage with us in the larger interest of taking these technologies to the needy in a short time. With the lockdown effecting reverse migration, CSIR took upon itself to provide tons of nutritious and immunity-boosting foods. The recently launched KisanSabha portal and App supports the farmers to get better prices for their produce. It is very heartening that the farming community has received the App very well. We hope that this compendium will not just give an insight into the COVID-19 technologies developed by CSIR so far, but will also spur more innovations. An 'Aatma Nirbhar Bharat' is high on our agenda, and we are eager to partner with more industries to take these technologies to the users. Your feedback and ideas are very welcome. Shekhar C Mande Director General Council of Scientific and Industrial Research iii

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Introduction The ongoing pandemic of Coronavirus Disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2). The World Health Organization (WHO) declared the outbreak to be a Public Health Emergency of International Concern on 30th January 2020 and recognized it as a pandemic on 11 March 2020. As of 1 July 2020, there are 5,86,956 cases of COVID-19 in India. Developing technological solutions that are needed to tackle this unprecedented challenge requires strong and cutting edge R&D capability and capacity in diverse disciplines ranging from biological sciences (vaccines, diagnostics, sequencing, testing of drugs) to chemical sciences (drugs: repurposed and new drugs) and engineering (ventilators, PPEs) and interdisciplinary approach transcending barriers. CSIR is uniquely placed as an S&T organization to deliver these at this critical juncture, having proven expertise in sequencing (first human genome sequencing), diagnostics for rare genetic diseases and being the fountain head of generic industry in the country. With expertise ranging from development of aircrafts to advanced materials, CSIR is committed to harness its vast scientific human resource and its considerable capacity and is well poised to serve the diverse needs required immediately and also plan for long term solutions that are needed to control this epidemic. This calls for a strategic, well-coordinated and integrated approach in cooperation with all relevant stakeholders and aligned to government’s strategy. CSIR Strategy to Fight COVID-19 CSIR has advantageously positioned itself to pursue the focused R&D to develop, integrate, scale- up, and deploy necessary technological interventions for combating coronavirus Digital and Molecular Surveillance pandemic in the country. Considering the multifarious problems created by coronavirus which require interventions Rapid and Economical Diagnostics in several areas and multi-pronged strategy, CSIR has set up five technology verticals for addressing the pandemic. New & Repurposed Drugs and These verticals are need-based and Vaccines span multiple research labs and disciplines and draw upon the strength Hospital Assistive Devices and PPEs of scientists, students and harness it for the fight against COVID-19. In addition, CSIR is also working on promoting rural employment and providing ready-to-eat food to the needy migrants. Supply Chain & Logistics CSIR has developed several COVID-19 focused technologies and products ranging from sanitizers & masks to improved tests and diagnostics and ventilators, buildings and structures. The technologies, products and processes listed in the compendium are available for non-exclusive technology transfer. Out of 105 technologies and products in this compendium, 58 have been transferred to various industry partners. For the others, the technologies are in different stages of readiness, the most basic being a working prototype. Interested start-ups and industries may contact the concerned CSIR laboratory for further discussion, and technology transfer. v

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Contents Foreword iii Introduction v Rapid and Economical Diagnostics 3 Dry Swab-based RNA Extraction Free Direct RT-PCR Diagnostics 3 FnCas9 Editor Linked Uniform Detection Assay (FELUDA) 3 IgG/IgM Detection Using a Biolayer Interferometry 4 Micro PCR with Disposable Chip 5 NGS-based High-Throughput Diagnostics 5 One-step RT PCR Kit-COVID-19 6 RT-LAMP Diagnosis of COVID-19 6 Development of Repurposed Drugs/New Drugs & Vaccine 9 Coronavirus Culture 9 Process Development of Drugs Repurposed for COVID-19 9 Process for Niclosamide 10 Repurposing of Umifenovir against COVID-19 10 Repurposing of Colchicine for COVID-19 treatment 10 Synthetic Process for Camostat Mesylate 10 Process for Tilorone Dihydrochloride (Interferon Inducer) 11 Zinc Gluconate Vitamin C Formulation (Zincona-C) for Immunity Improvement 11 Hospital Assistive Devices and Personal Protective Equipment (PPE) 15 Ventilators, Oxygen Concentrators and Other Devices 15 Aerosol Canopy for Dental Procedures 15 Bi level Positive Airway Pressure (BiPAP) System Portable Ventilator 15 Hospital Care Assistive Robotic Device (HCARD) 16 Intubation Hood 16 Oxygen Enrichment Unit (OEU) based on Membrane Technology For Oxygen Therapy 17 Pressure Sensor 17 Respiration Assistance Intervention Device- A Portable Ventilator (Respi-AID) 18 vii

Personal Protective Equipment 18 Coverall Suit 18 Efficient Antimicrobial Materials, Formulations and Coatings, Cotton Fabrics for Reusable PPE (Masks/Gowns) 19 Masks and Shields 20 3-D Printed Face Shield 20 3-D Printed Face Mask 20 Face Shield 20 High Efficiency Hydrophobic Three-Layered Facemask 21 Membrane Based Face Mask 21 Printable Face Shield to Protect from COVID-19 21 PolyTi: A Biopolymer Coated Medical Grade Mask 22 Reusable Face Mask with Antimicrobial Coating 23 Reusable Stopgap Face Mask 23 Makeshift Hospitals 24 Karuna Bhawan (Makeshift Hospital for COVID-19) 24 Prefab Foldable Modular Structure for Makeshift Transit Hospital for COVID-19: Poli-Tal(M) 24 Temporary and Short-Term Hospital Structures for Rapid Construction 25 Waste Disposals 25 Flocculant based Gelation‚ Solidification‚ Disinfection System for Medical Waste Disposal 25 GreenDispo (MIDI): Eco-friendly & Energy Efficient Electric Incinerator 26 Dispensers and Disinfectants 26 Air Sanitizer 26 Disinfectant Spray (JeevNasi) 27 Electrostatic Disinfection Machine (eSPRAY & Covid-Spray) 27 Flomop: Floor Disinfectant 28 Foot Operated Hand Washing System (Hasta-Suraksha) 28 Hands Free Hand Sanitization System 29 Hands Free Hand Wash: Foot Controlled Water Tap 29 Hands Free Hand Washing Point-NEERWASH 29 Herbal Soap 30 NEERAKSHA Liquid Disinfectant 30 NEERJANTUK: Hands Free Hand Sanitization Point 31 Scientific Know-how on Ozone-based Air Disinfection for Closed Un-occupied Chambers/rooms 31 Smart Touch-Free (Palm Safe) & Automatic Hand Sanitizer Dispenser (Indoor & Outdoor) 31 Swabee - Floor/kitchen/labtop Electronic Devices Disinfectant 32 UV-Clean Disinfecting Unit (λ-FLASHBOX) 32 viii

Hand Sanitizers 36 Alcohol Based Hand Sanitizer Gel 37 Alcohol Based Liquid Hand Sanitizer 37 Hand Rub Sanitizer 38 Hand Sanitizer @ CSIR-CIMAP 38 Hand Sanitizer @ CSIR-IHBT 38 Hand Sanitizer @ CSIR-IICT 39 Hand Sanitizer with Enhanced Skin Care 39 Hand Sanitizer, Liquid Soap & Soap Bar 39 Miscellaneous 40 Herbal Cough Syrup 40 Insulated Coffin 41 Nasopharyngeal Swabs 41 Sustained Release Long Acting Steam Inhalation Drops (NiiSTEAM) 41 Trikatu Syrup 42 Supply Chain & Logistics Support Systems 45 AarogyaPath – Healthcare Supply Chain Solution 45 KisanSabha 46 Short-term Prediction of COVID-19 Positive Cases in India 46 Other COVID-19 Technologies 49 CIM Paushak-Rasayan based Awaleh 49 CIM Phal-Se-Nutritive granules 49 Iron and Zinc Enriched Spirulina (Nut and Chocolate Bars) 50 Multigrain Protein Mix 50 Nutra Chikki with added Spirulina 51 Nutri Fruit-Bars enriched with Vitamin C and Zinc (Mango and Mixed fruit bars) 51 Protein & Fiber Enriched Cereal Bars 52 Ready-to-Eat Foods for Ethnic Himachali Cuisines 52 CSIR Laboratory Contacts 55 Industry Contacts 71 ix

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Compendium of CSIR’s COVID-19 Technologies Rapid and Economical Diagnostics 1

CSIR Technologies for COVID-19 Mitigation 2

CSIR Technologies for COVID-19 Mitigation Rapid and Economical Diagnostics The key to flattening the curve in the number of Coronavirus cases is the detection of the infected at the earliest and isolating them. A combination of digital and molecular surveillance with rapid diagnosis is the need and CSIR is striving towards that using multiple strategies. CSIR was one of the first institutions to carry out testing in the country. With state-of the-art genomics and molecular biology laboratories in the CSIR network, CSIR has not only been at the forefront of testing but also developing cost-effective and accurate diagnostic kits for detecting the COVID-19 virus. Some of the technologies developed by CSIR are: Dry Swab-based RNA Extraction Free Direct RT-PCR Diagnostics ►► Dry swabs (with nasopharyngeal samples on it) are sent from collection centres to testing centres. ►► TE buffer is used to isolate the biological samples, skip RNA isolation, and proceed with RT-qPCR without compromising the sensitivity of the COVID-19 tests. Laboratory/Institute Open for Industry Partnership CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB) FnCas9 Editor Linked Uniform ►► FELUDA output can be adapted to multiple Detection Assay (FELUDA) signal detection platforms and can be quickly designed and deployed for versatile ►► Detection of pathogenic sequences or applications including rapid diagnosis of variants in DNA and RNA through a infectious diseases such as COVID-19. point-of-care diagnostic approach is useful for rapid clinical prognosis. ►► The knowledgebase encompasses a comprehensive pipeline including protein ►► FnCas9 Editor Linked Uniform Detection expression, sgRNA design, preparation of Assay (FELUDA) employs an accurate RNA complexes, detection methods that enzymatic read out for detecting nucleotide are dependent on applications, SOPs for sequences, identifying nucleobase identity pathogen detections and SNP detections. and inferring zygosity with precision. 3

CSIR Technologies for COVID-19 Mitigation Laboratory/Institute Industry Partner Tata Sons Ltd CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB) IgG/IgM Detection Using a Biolayer Interferometry ►► Development of bilayer interferometry technique of subtypical testing of COVID-19. ►► This technology will be useful for high volume places like hospitals. ►► Machines to be deployed in potential testing centres. Laboratory/Institute Industry Partner CSIR-Centre for Cellular and Molecular Biology Oncosimis Biotech Pvt. Ltd. (CSIR-CCMB) 4

CSIR Technologies for COVID-19 Mitigation Micro PCR with Disposable Chip ►► Handheld Polymerase Chain Reaction (PCR) system for DNA sequence amplification. ►► Consists of a disposable micro fabricated amplification chip, capable of handling 20- 150 µl sample volume. ►► Micro-heater temperature is controlled using precisely designed PID controller. The system is capable of controlling the temperature cycles with precision, suitable for PCR application. ►► Control circuitry generates the temperature/ time cycles as per PCR amplification requirements. ►► Works on Denaturation-Annealing-Extension for DNA synthesis. Laboratory/Institute Industry Partner CSIR-Central Electronics Engineering Research Oncosimis Biotech Pvt. Ltd. Institute (CSIR-CEERI) NGS-based High-Throughput Diagnostics ►► The technology allows using Next Generation Sequencing (NGS) for a high-throughput COVID-19 testing-of up to 10,000-50,000 samples in one go at each facility. ►► The technology is now being tried at a pilot scale for the states of Telangana and Karnataka. Laboratory/Institute Industry Partner Syngene International Ltd CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB) 5

CSIR Technologies for COVID-19 Mitigation One-step RT PCR Kit-COVID-19 ►► Recombinant clones for highly efficient Reverse Transcriptase and hot start Taq DNA polymerase. ►► Formulated one step picomolar sensitive RT PCR kit. ►► Tested efficiency of the kit against COVID-19 samples using TaqMan probes. Laboratory/Institute Open for Industry Partnership CSIR-Indian Institute of Chemical Technology (CSIR-IICT) RT-LAMP Diagnosis of COVID-19 ►► Sample is collected as a nasopharyngeal swab in a viral transport medium. ►► RNA is extracted from the sample and used for RT-LAMP. ►► RT-LAMP based diagnosis relies on conversion of RNA to cDNA and then an isothermal amplification of specific viral regions through specially designed primers. ►► Addition of SYBR Green I dye to the reaction mixture results in green fluorescence on accumulation of amplified DNA in a positive sample. Thus a simple visual detection can ascertain if the sample is COVID-19 positive or negative. ►► This rest is simple and does not require expensive instrumentation and expertise. ►► The sensitivity and accuracy of the test almost matches the current gold standard qPCR test. Laboratory/Institute Industry Partner Reliance Industries Limited, Mumbai CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM) 6

Compendium of CSIR’s COVID-19 Technologies Development of Repurposed Drugs/ New Drugs & Vaccine 3

CSIR Technologies for COVID-19 Mitigation 8

CSIR Technologies for COVID-19 Mitigation Development of Repurposed Drugs/ New Drugs & Vaccine To combat the virus, CSIR is exploring all avenues and supporting new ideas that have a clear deployment strategy. CSIR has further defined its strategy in this vertical by setting up focused groups to look at multiple pathways for developing drugs: i) Molecular modelling of drugs; ii) Host-target interactions; iii) Crystal engineering; iv) Batch to continuous process; v) In-silico screening of existing drugs and natural products; vi) Scouting for non-infringing routes, and vii) Host-dependent pathways for APIs. Coronavirus Culture ►► Stable cultures of coronavirus in Vero and E6 cells available. ►► These cultures can be used for developing vaccines, testing drugs and sanitization strategies. Laboratory/Institute Industry Partners CSIR-Centre for Cellular and Molecular Biology 1) VINS Bioproducts Pvt. Ltd. (CSIR-CCMB) 2) Bharat Biotech International Ltd. Process Development of Drugs Repurposed for COVID-19 ►► Process developed for Nitazoxanide, EIDD 1931 & EIDD 2801. ►► Non-infringing routes developed for the APIs. ►► Nitazoxanide is currently under clinical trials in Mexico. ►► EIDD 2801 is currently under clinical trials in USA & UK. Laboratory/Institute Open for Industry Partnership CSIR-National Institute for Interdisciplinary 9 Science and Technology (CSIR-NIIST)

CSIR Technologies for COVID-19 Mitigation Synthetic Process for Camostat Mesylate Process for Niclosamide ►► Synthesis of Camostat mesylate, starting ►► The gram scale process for synthesis of from indigenous and less expensive raw niclosamide developed. materials that are mostly available in India. ►► It is an FDA approved anti-helminthic drug. ►► The innovation includes the improvement It has been found to be a potential of existing methodologies by reducing the anti-viral agent and is one of the top 25 number of steps. shortlisted repurposed drugs. Laboratory/Institute ►► The synthetic process technology has been CSIR-Central Salt & Marine developed. Chemicals Research Institute (CSIR-CSMCRI) Laboratory/Institute CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM) Open for Industry Partnership Open for Industry Partnership Repurposing of Colchicine for Repurposing of Umifenovir COVID-19 treatment against COVID-19 ►► This is a FDA approved drug for gout. ►► An economical process technology has been developed using indigenously available ►► Tablets are available with the Cadila. key starting materials. ►► The same dose of tablets (0.5 mg) is ►► CSIR-CDRI has received the permission from propsoed to be used for COVID-19 trial. Central Drugs Standard Control Organization for conducting the Phase III clinical trial with ►► The clinical trial strategy for conducting Umifenovir entitled \"Randomised, double Phase II clinical trial of colchicine along blind, placebo controlled trial of efficacy, with a comparative arm of SoC, has been safety and tolerability of Antiviral drug prepared. Umifenovir vs standard care of therapy in non-severe COVID-19 patients.” Laboratory/Institute CSIR-Indian Institute of Laboratory/Institute Integrative Medicine CSIR-Central Drug Research (CSIR-IIIM) Institute CSIR-Indian Institute of (CSIR-CDRI) Chemical Technology (CSIR-IICT) Industry Partner Medizest Pharmaceuticals Industry Partner Pvt. Ltd. Laxai Life Sciences 10

Process for Tilorone CSIR Technologies for COVID-19 Mitigation Dihydrochloride (Interferon Inducer) Zinc Gluconate Vitamin C Formulation (Zincona-C) for ►► Tilorone is used as a Immunity Improvement broad-spectrum antiviral discovered more and chemical process that is ►► The Formulation is based on green an improvement of existing synthetic technology for Zinc gluconate and natural strategy for Tilorone dihydrochloride vitamin C i.e. Acerola Cherry extract. using less expensive and easily available raw materials. ►► Capsules and syrup have been prepared as per RDA. Laboratory/Institute CSIR-Indian Institute of ►► The product is being taken forward for the Chemical Biology clinical trials. (CSIR-IICB) ►► Applied for trade mark (Zincona-C). Laboratory/Institute CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM) Open for Industry Partnership Open for Industry Partnership 11

CSIR Technologies for COVID-19 Mitigation 12

CSIR Technologies for COVID-19 Mitigation Hospital Assistive Devices and Personal Protective Equipment (PPE) 13

CSIR Technologies for COVID-19 Mitigation 14

CSIR Technologies for COVID-19 Mitigation Hospital Assistive Devices and Personal Protective Equipment (PPE) A major challenge during the corona pandemic globally has been the shortage of hospital assistive devices such as ventilators and oxygen enrichment devices. Another critical requirement in this pandemic has been the need for personal protective equipment (PPEs) to the caregivers who include doctors, nurses and para medical staff given the infectious nature of the virus. Under this vertical, CSIR has developed Hospital Assistive Devices (HADs) such as ventilators, oxygen enrichment units, hands-free dispensers, electrostatic disinfector, and several kinds of personal protective equipment. Not just engineered devices and equipment but relatively simple but essential items like hand- sanitizers and face masks have also been developed by many labs and distributed widely as a social responsibility of the CSIR labs and institutes. Ventilators, Oxygen Concentrators and Other Devices Aerosol Canopy for Dental Laboratory/Institute Procedures CSIR-Central Scientific Instruments Organisation ►► Aerosol canopy shields dentists and dental (CSIR-CSIO) assistants from infectious droples and aerosols of COVID-19 patients. Industry Partner Nigam Scientific Works ►► Allows the doctor to move his/her arms freely to perform all necessary tasks during dental procedures. ►► Some features include, removable and disposable sheets, reduced dependencies on sterilisation, can be fixed on patient, chairs and carts. Bi level Positive Airway Pressure (BiPAP) System Portable Ventilator ►► SwasthVayu is a BiPAP Non-Invasive ventilator. It is a microcontroller-based precise closed-loop adaptive control system with a built-in biocompatible “3D printed manifold & coupler” with HEPA filter (Highly Efficient Particulate Air Filter). It has features like Spontaneous, CPAP, Timed, AUTO BIPAP modes with provision to connect Oxygen concentrator or Enrichment unit externally. 15

CSIR Technologies for COVID-19 Mitigation ►► The system is best suited for treating the mild and moderate COVID-19 infections. ►► The system has been certified for safety and performance by NABL accredited ►► It is currently undergoing clinical trials at agencies. few hospitals. ►► Easy to use without any specialized nursing, cost-effective, compact and configured with the majority of indigenous components Laboratory/Institute Industry Partners CSIR-National Aerospace Laboratories 1) Apollo Computing Laboratories Pvt. Ltd. (CSIR-NAL) 2) Kavitul Technologies Pvt. Ltd. 3) Paras Defence & Space Technologies 4) Datasol (B) Pvt. Ltd. 5) Nfotec Digital Engineering Pvt. Ltd. 6) Unimech Aerospace & Manufacturing Pvt. Ltd. Hospital Care Assistive Robotic ►► Collision avoidance circuitry. Device (HCARD) ►► 12V 7Ah battery powered robot. ►► Device relates to a nursing care system Laboratory/Institute that navigates the existing facility without CSIR-Central Mechanical intervention and within the programmed Engineering Research Institute constraints to deliver and transport (CSIR-CMERI) materials in the ward. Open for Industry Partnership ►► It is able to provide two-way communication between patient and clinicians. ►► Remote activation of drawers. ►► Bi-directional voice and video communication. Intubation Hood ►► Design can be modified by special needs of different types of doctors while examining ►► It is suitable for doctors who require the patients. a transparent hood when carrying out treatment procedures Laboratory/Institute such as intubation. CSIR-Institute of Minerals and Materials Technology ►► Can also be used (CSIR-IMMT) during any oral examination by Industry Partner dentists. Gitanjali Awards Pvt. Ltd. ►► Made of acrylic sheets, cutting can be done using laser cutters. 16

CSIR Technologies for COVID-19 Mitigation Oxygen Enrichment Unit (OEU) Air (Output of device): (i) Flow type: based on Membrane Technology Continuous; (ii) Oxygen Purity: 30-40 % For Oxygen Therapy (adjustable as per need) (iii) Flow rate: 0.5 to 5, 10, 15 lit/min (adjustable as per ►► A startup of CSIR-NCL, Genrich Membranes the requirement; (iv) Oil free (v) free from has developed Oxygen Enrichment Unit pathogens. (OEU) based on innovative, indigenously developed Hollow-Fiber Membrane ►► Product is TUV certified. technology. This unit provides ~35-40% Oxygen enriched air. ►► The device consists of (1) membrane cartridge (filter), (2) pressure-gauge, (3) flowmeter, (4) humidifier bottle, (5) nasal- cannula, (6) oil free compressor and (7) tubing & fittings. ►► The atmospheric air under certain pressure (4-5 bar) passes through membrane cartridge wherein oxygen is permeated through membrane surface preferentially over other gas components in the air. This happens due to intrinsic high sorption capacity of oxygen in to membrane matrix. ►► Specifications of Oxygen Enriched Laboratory/Institute Industry Partners CSIR-National Chemical Laboratory 1) Genrich Membranes Pvt. Ltd. (CSIR-NCL) 2) Bharat Electronics Ltd. Pressure Sensor 17 ►► Pressure sensors developed for application in Type-B and Type-C ventilators. ►► Pressure sensor is one of the various components required for making a ventilator which are in high demand in hospitals for COVID-19 patients treatment. ►► In-house developed MEMS piezo-resistive pressure sensor interfaced with a commercial IC for sensor output amplification, bias generation and temperature compensation. Currently, pressure output is in analog form. The developed product, pressure and output

CSIR Technologies for COVID-19 Mitigation voltage range is also configurable. Pressure port Laboratory/Institute connectivity can also be configured as per user CSIR-Central Electronics Engineering requirement. In addition self-test, voltage protection options are also available to user optionally. Research Institute (CSIR-CEERI) ►► Double side polished silicon wafers with (100) Open for Industry Partnership orientation and a thickness of 370 ± 1 µm are used as starting substrate. Thermal oxide used as insulator and etching performed using buffered HF. Poly silicon resistors are implemented on a diaphragm achieved by back-side etching. Poly resistors are connected in wheatstone bridge configuration. A commercial interface IC interfaced with a closed bridge pressure sensor. An on chip temperature sensor compensates temperature induced non-linearities generated from sensor. Respiration Assistance Laboratory/Institute Intervention Device-A Portable CSIR-Central Scientific Ventilator (Respi-AID) Instruments Organisation (CSIR-CSIO) ►► The Respiration Assistance Intervention Device (Portable Ventilator) is based on Industry Partner the operation of Ambu Bag, which is used Sivapriya Exim Pvt. Ltd. conventionally for manual respiration. ►► Automated Ambu Bag operation is based on double flap motorised mechanism. ►► Provision to set the following input parameters for functioning of the device: ••Volume of gas to be delivered to the patient (Tidal Volume) ••Rate at which the gas is to be delivered to the patient (Respiration Rate) Personal Protective Equipment Coverall Suit ►► Made of certified polypropylene spun laminated mulit-layered non-woven fabric based coverall to ensure safety of doctors, nurses, paramedical staff and healthcare workers. ►► The coverall suit is made with indigenous materials. 18

►► It has gone through stringent testing at CSIR Technologies for COVID-19 Mitigation SITRA, Coimbatore and have been certified Laboratory/Institute to ASTM F1670/F1670M-08(2014) for use. CSIR-National Aerospace Laboratories (CSIR-NAL) ►► Specifications: Fabric-Polypropylene spun laminated multi-layered non-woven; single Industry Partner use; built-in hood cap and zipper covered MAF Clothing Pvt. Ltd. with flap; universal fit, soft elastic fitted around hood, wrist & ankles; and shoe cover fitted with soft elastic at two levels. ►► Several thousands of pieces have been produced with industry partner. Efficient Antimicrobial ►► Optimized protocols for spray coating the Materials, Formulations and formulations on cotton fabrics Coatings, Cotton Fabrics for Reusable PPE (Masks/Gowns) ►► Masks modified with these antimicrobial layers are expected to prevent the passage ►► Developed to minimize the use of synthetic of virus as well as disinfect them, without polymers and substitute the same with affecting air permeability. reusable cloth-based layers, with a possibility to add-in a replaceable insert of ►► The coated fabric has shown more an antimicrobial, filter-efficient, protective than 99.9% microbial disinfection under coating on fabrics. laboratory conditions. ►► These coatings are realized through ►► Design, testing and manufacturing details indigenously developed spray formulations, are under discussion with the identified whose components are already tested for Industry partner. antimicrobial activity. ►► Demonstrated the feasibility of adding the replaceable insert in both common and designer PPE. Laboratory/Institute Open for Industry Partnership CSIR-National Institute for Interdisciplinary 19 Science and Technology (CSIR-NIIST)

CSIR Technologies for COVID-19 Mitigation Masks and Shields 3-D Printed Face Shield ►► Developed using biodegradable polymers (PLA -frame and Cellulose Acetate -visor); Light weight (Only 35 grams) convenient for long time wearing; thickness of visor is only 100 microns. ►► Protection from top as well as bottom to prevent chin and lower part of the jaw of the users. Laboratory/Institute Open for Industry Partnership CSIR-Central Salt & Marine Chemicals Research Institute (CSIR-CSMCRI) 3-D Printed Face Mask Laboratory/Institute CSIR-Institute of Minerals and ►► Designed to have an airtight fit. Materials Technology ►► Large snout for more air intake. (CSIR-IMMT) ►► Replaceable filters. ►► Disposable filter made of multilayer filter Industry Partners paper. 1) Professional Solutions 2) Wise Solution Face Shield Laboratory/Institute CSIR-Central Salt and Marine ►► Face shields have been manufactured and Chemicals Research Institute their compliance checked. (CSIR-CSMCRI) ►► 10 pieces of face shieldsare under testing Open for Industry Partnership as per ANSI Z87.1-2015. 20

High Efficiency Hydrophobic CSIR Technologies for COVID-19 Mitigation Three-Layered Facemask Laboratory/Institute CSIR-Central Mechanical ►► The facemask is composed of two/three Engineering Research Institute hydrophobic non-woven polypropylene (PP) (CSIR-CMERI) layers in the outer and inner side and a 'High Efficiency Particulate Air' filter in the Open for Industry Partnership middle. Laboratory/Institute ►► The performance of the developed mask CSIR-Central Salt and Marine certified from SITRA. Chemicals Research Institute (CSIR-CSMCRI) Membrane Based Face Mask Open for Industry Partnership ►► Maximum blocking size less than 0.3 micron. ►► Due to presence of hydrophobic polyester thin film, the mask is washable with detergent for the reuse. ►► Abundant air permeability across nonwoven barrier (0.7 cc/cm2s) ensures good breathability. ►► Optimized loading of polymer with anti- microbial properties is expected to render antimicrobial activity on the outer surface of the main barrier. Printable Face Shield to Protect ►► The material used for the development from COVID-19 of face shield is bio-degradable polymer based composite. ►► Helps to protect healthcare workers who treat COVID-19 patients and guards the ►► Light weight, yet robust face shield that fits eyes and face against potential infection in ergonomically on the users’ face. from the cough and sneeze of patients. ►► Issue on blurred vision occurring most ►► Helps to prevent the persons from touching commonly with free-standing OHP sheets their face. has been addressed through modified design pattern. ►► Designed to be placed over a conventional surgical mask. ►► Fog free design. ►► This face shield is fabricated using 3D ►► Better coverage to chin, without affecting printing with fused deposition modelling air flow. technique and the design could be mimicked with inject moulding. ►► Certification as per the ANSI standard (Certified by CIPET, Chennai) obtained. 21

CSIR Technologies for COVID-19 Mitigation Laboratory/Institute Industry Partner Lycan 3D CSIR-Central Electrochemical Research Institute (CSIR-CECRI) Poly Ti:A Biopolymer Coated ~99.7 % bacterial filtration efficiency Medical Grade Mask against Staphylococcus aureus ATCC 6538 and 91.0% efficiency against 0.3 Œºm ►► Two layered masks that use biopolymer particulates matter. (Bacterial cellulose) coated mask, which are having much higher surface area and ►► Masks are very cost effective, lightweight very fine nanofiber of cellulose to trap and comfortable to wear. viruses and bacteria. ►► The South India Textile Research ►► Poly-Ti mask indigenously developed Association (SITRA), Coimbatore, a using the patented technology of CSIR- government approved nodal agency for NCL on Bacterial cellulose, mask showed medical textiles, carried out these tests according to ASTM standards of the mask. Laboratory/Institute CSIR-National Chemical Laboratory (CSIR-NCL) Industry Partner Setlab India 22

CSIR Technologies for COVID-19 Mitigation Reusable Face Mask with Antimicrobial Coating ►► Designed and developed for protection from efficiency at 0.3 microns, thus comparable particulate emissions and microbes. with the commercially available masks with Class I flammability, splash resistance and ►► The tri-layered mask consists of the excellent breathability. hydrophobic outer layer that repels the liquid aerosol and the middle bactericidal ►► The properties of the masks have been layer kills the microbes that comes in certified by SITRA. contact with the masks thereby providing dual protection benefits to the end-users. ►► The inner hydrophilic layer absorbs the hot air, sweat and facilitates improved breathability. ►► These masks and the coatings have been designed and formulated to sustain up to 30-50 washes. ►► These tri-layered masks have ≥ 95% of particulate and bacterial penetration Laboratory/Institute Industry Partner CSIR-Central Electrochemical Research RS Nanotechnologies Institute (CSIR-CECRI) of filter membrane by order of 1/6th when compared with existing N95 respirators. Reusable Stopgap Face Mask ►► Reduces the environmental impact due ►► Reusable Stopgap Face Mask (SFM) to excess polymer membrane waste deveoped via injection moulding. generated during the COVID-19 outbreak. ►► Enables high throughput manufacturing ►► Certified medical grade materials offer of SFM to meet the rising demand for PPE better durability, and is lightweight. during the pandemic. ►► The replaceable filter membrane can be ►► SFM was designed by incorporating used with certified N95, N99 (or) surgical the principles of aerodynamics to mask membranes, depending upon the minimize airflow resistance. Further, the protection required by the user. developed SFM also minimize the usage Laboratory/Institute Industry Partner CSIR-National Institute for Interdisciplinary AVK TOOLINGS Science and Technology (CSIR-NIIST) (Discussions on) 23

CSIR Technologies for COVID-19 Mitigation Makeshift Hospitals Karuna Bhawan (Makeshift weight prefabricated steel portals that are Hospital for COVID-19) foldable, easily to erect, reusable, safe, comfortableto the occupants and cost- ►► A portable, prefabricated, foldable steel effective. structure of 30.23 sq mt per module plinth area has been designed with adequate ►► Necessary electric, water-supply, heating/ insulation and water proofing features. The cooling services along with other medical structure is modularand can be constructed service lines like oxygen supply etc can be at site. integrated with this design. ►► The design complies to relevant standards ►► Plan makes use of optimum space for make-shift hospitals. Makes use of light utilization, scalability (both ways), appealing aesthetics. Laboratory/Institute Industry Partner Everest Industries Ltd. CSIR-Central Building Research Institute (CSIR-CBRI) Prefab Foldable Modular electricity and water supply etc. All Structure for Makeshift Transit piping can be accommodated within the Hospital for COVID-19: panels including switch boards and pipe Poli-Tal(M) connections. ►► The modular unit is a single foldable unit ►► The modular units are spacious and are having a total weight of around one tonne. multifunctional, can be used for patients, This structure module can be folded flat doctor's cabins and testing labs. so that it can be transported easily. The module can be fabricated in a yard with ►► The total size of the full size module is simple fabrication technology that utilizes around 6m x 3m x 0.150m which can be welded standard steel sections. The fully easily transportable from one place to folded modules can be taken to the site and another. The size is customizable during deployed after making the site levelled and fabrication as per the requirement. ready. ►► Some of the units can be converted and ►► One hospital of around 100 beds can be made as Toilet core units commonly for installed within a week including beds, four to five units. ►► Each unit can accommodate two to three beds. Laboratory/Institute Industry Partners CSIR-Structural Engineering Research Centre 1) B.G Shirke Construction Pvt. Ltd. (CSIR-SERC) 2) Consortium Techno Solutions Pvt. Ltd. 24

Temporary and Short-Term CSIR Technologies for COVID-19 Mitigation Hospital Structures for Rapid Construction ►► With the ready to build site and minimum preparation, the construction of the units ►► Light weight structure with ready to fix should not take more than 6 hours. features. ►► Other functional requirements including air ►► Flexible to accommodate 4 to 50 beds by conditioning can be accommodated in the increasing the number of repetitive units of proposed scheme. size 9.14 m x 4.0 m. ►► The structural parts are to fabricated in ►► Multiples of such units can be joined to factory and can be quickly assembled at cover the available space and requirements. site. ►► All the joints are detachable and can be ►► Owing to the size and shape of the units, fixed within few hours. any plan area can be adjusted with ease. The system like radial or linear arrangements can be adopted. Laboratory/Institute Industry Partners CSIR-Structural Engineering Research Centre 1) B.G Shirke Construction Pvt. Ltd. (CSIR-SERC) 2) Consortium Techno Solutions Pvt. Ltd. Waste Disposals Flocculant based Gelation‚ Solidification‚ Disinfection System for Medical Waste Disposal Design of all-in-one sample Collection - Disinfection - Disposal Prototypes ►► The flocculant system is capable of instantaneous flocculation/gelation, thereby disinfecting both liquid as well as solid samples, rendering them non-infectious, with >99.9% microbial disinfection. ►► Segregation, transportation and incineration of such disinfected medical wastes are easier, safer and decrease medical waste disposal costs for a healthcare facility. ►► Design, testing and manufacturing details Laboratory/Institute are under discussion with the identified CSIR-National Institute for industry partner. Interdisciplinary Science and Technology (CSIR-NIIST) ►► A combination of flocculant materials have been identified. Industry partner CML Biotech Pvt. Ltd. ►► Optimized the composition for effective Open for Industry Partnership flocculation of fluid samples. ►► Treated microbial cultures showed 99% microbial disinfection. 25

CSIR Technologies for COVID-19 Mitigation GreenDispo (MIDI):Eco-friendly unit, at a temperature more than 950 & Energy Efficient Electric ∞C can be retrofitted, while disposal of Incinerator bleached pads, masks or gloves and high plastic content. ►► Instant disposal in a scientific & hygienic manner. ►► Has auto power & thermal cut-off and automatic temperature controls. ►► Energy efficient heaters and innovative design of combustion chamber. ►► Suitably insulated with safe device surface temperatures. ►► Incinerates used sanitary pads &cellulose masks at a temperature more than 800C. ►► Easy to operate and is user friendly with minimal maintenance. ►► Exhaust emissions comply to BMW Management Rules, 2016 for use with ►► Useful for hospitals in towns and villages sanitary napkins. where biomedical waste management facility is not available including quarantine ►► Ash collected in separate tray with < 5% ash centres, containment zones, school & generated. institutes, community toilets, girls hostels, hospitals, offices & industries, convention ►► Additionally a post combustion secondary centres, metro or railway stations, malls, etc. Laboratory/Institute Industry Partner Sowbal Aerothermics (SA) CSIR-National Environmental Engineering Research Institute (CSIR-NEERI) Dispensers and Disinfectants Air Sanitizer ►► An engineered system for disinfecting aerosols. ►► The unit absorbs aerosols from a distance and exposes it to a combination of germicidal UV radiations and filters and releases out clean and fresh air. ►► The unit may help in controlling aerosol transmission. ►► For application in hospitals, clinics, testing labs, office cabins, meeting rooms, etc. where aerosol mediated transmission of disease is very high. ►► Highlights include high efficiency, low cost, minimum infrastructure requirement for fabrication, and low power requirement. Laboratory/Institute Industry Partner Ecocure Technologies CSIR-National Institute for Interdisciplinary Science & Technology (CSIR-NIIST) 26

CSIR Technologies for COVID-19 Mitigation Disinfectant Spray (JeevNasi) ►► Effective aerosol-based spraying system that uniformly spreads a minimum amount of disinfectant, while covering the maximum area. ►► Can be made with the components available in the market. ►► Small and medium scale industries can easily and quickly produce this at economical price. Laboratory/Institute CSIR-Institute of Minerals and Materials Technology (CSIR-IMMT) Industry partners 1) Sharp Control Equipments Pvt. Ltd. 2) Supply Zone Electrostatic Disinfection Machine (eSPRAY & Covid- Spray) ►► Works based on the electrostatic principle, producing uniform and fine spray droplets of disinfection material in the range of 10- 20 µm. ►► Due to the small size of droplets, the surface area of spray droplets increases which enhances the interaction with the harmful microorganisms. ►► Charged droplets cover the directly exposed and obscured surfaces uniformly with increased efficiency and efficacy. ►► The machine uses very less disinfection material as compared to conventional methods. Laboratory/Institute Industry Partners CSIR-Central Scientific Instruments 1) Dashmesh Industries Organisation (CSIR-CSIO) 2) Bharat Heavy Electricals Limited 3) Jhosna Corporation 4) Rite Water Solutions (I) Pvt. Ltd. 27

CSIR Technologies for COVID-19 Mitigation Flomop: Floor Disinfectant ►► Essential oil-based natural insect repellent formulation. ►► A fragrant formulation for the removal of dirt and dust. ►► Safe to use, non-toxic, environmentally friendly. Laboratory/Institute Industry Partner CSIR-Central Institute of Medicinal and Chaira Herbals Pvt. Ltd. Aromatic Plants (CSIR-CIMAP) Foot Operated Hand Washing System (Hasta-Suraksha) ►► Compact system is mechanically operated by foot. ►► Does not require any electricity and can be used at any convenient locations. ►► Has built-in mechanism for both water and liquid soap dispensing, controlled by foot through pedal and lever. ►► The system has been installed at various locations in Bhubaneswar. Laboratory/Institute Industry Partners CSIR-Institute of Minerals and Materials 1) Unicus Engg. Pvt. Ltd. Technology (CSIR-IMMT) 2) Blue Eye Industries 3) Sudha Industry 28 4) Paras Defence and Space Technologies Ltd 5) Sivapriya Exim Pvt. Ltd. 6) 360 Networks

CSIR Technologies for COVID-19 Mitigation Hands Free Hand Sanitization System ►► An innovative way of hand sanitizing system operated by foot. ►► Does not require electricity and can be used as either stand alone or attached to any existing washing basin. ►► Can be used both for both sanitizer and liquid soap dispensing. Laboratory/Institute Industry Partner 360 Networks CSIR-Institute of Minerals and Materials Technology (CSIR-IMMT) Hands Free Hand Wash: Foot Controlled Water Tap ►► A device for delivering water from a plumbing system. ►► Contorls the water outflow with the help of foot actuation. ►► Reduces water wastage. ►► Can be installed in existing faucet systems for multi-level flow regulation. Laboratory/Institute Industry Partner CSIR-Central Scientific Instruments Jupiter Aqua Lines Ltd. Organisation (CSIR-CSIO) Laboratory/Institute CSIR-National Environmental Hands Free Hand Washing Engineering Research Institute Point-NEERWASH (CSIR-NEERI) ►► Mechanically operated by foot. Industry Partner ►► Ensures safe and secure hand washing. MTC Fibrotech ►► Reduces chances of contamination. ►► System is stand alone and mobile. 29 ►► Can be customised

CSIR Technologies for COVID-19 Mitigation Herbal Soap • SDS, SLS and mineral oil free natural herbal soap with an effective anti- fungal, antibacterial, cleansing and moisturizing benefits. Laboratory/Institute Industry Partners 1) Sandeep Kumar & Co. CSIR-Institute of Himalayan Bioresource 2) A B Scientific Solutions Technology (CSIR-IHBT) 3) Geo Care NEERAKSHA Liquid Disinfectant ••Electro-chlorination process has reduced energy and environmental ►► Hypochlorite based mixed oxidant footprint. disinfectant solution for spraying. ►► The novelty and steps involved in ►► The salient features of process NEERAKSHA-H-EC process includes the NEERAKSHA-H-EC are as follows: following: ••Simple, non-tedious and ••Generates mixed oxidant solution. environmentally benign process for hypochlorite generation in presence of ••Higher concentration ( 1-7%) can donor. be achieved for transportation as compared to conventional electro- ••Proprietary donor functions as chlorinators producing hypochlorite activator-cum-oxidant and accelerates with strength of 0.7-0.8%. the electro-chlorination efficiency by a factor of 3-5. Laboratory/Institute Industry Partner CSIR-National Environmental Engineering Rudraksha Allied Chemical Pvt. Ltd. Research Institute (NEERI) 30

NEERJANTUK: Hands Free Hand CSIR Technologies for COVID-19 Mitigation Sanitization Point Laboratory/Institute ►► Mechanically operated by foot, and thus avoid CSIR-National Environmental chances of contamination amongst the users. Engineering Research Institute (CSIR-NEERI) ►► Ensure the safe and secure hand sanitization, thus reduces chances of contamination. Industry Partner MTC Fibrotech ►► System is stand alone and mobile. ►► Low & easy maintenance. ►► Can be customised. Scientific Know-how on Ozone- Laboratory/Institute based Air Disinfection for CSIR-Central Food Technological Closed Un-occupied Chambers/ Research Institute (CSIR-CFTRI) rooms Industry Partner ►► Air disinfection for hospital and non- Faraday Ozone Products hospital settings (hotels, restaurants, Omniscient Treatment offices, schools etc). Technologies Pvt. Ltd ►► Validated for efficacy with 4 indicative Indoor Unit microbes in BSL-II facility and test rooms. Outdoor Unit Smart Touch-Free (Palm Safe) & Automatic Hand Sanitizer Dispenser Laboratory/Institute (Indoor & Outdoor) CSIR-National Institute Indoor unit for Interdisciplinary Science & Technology ►► Automatically dispenses adequate amount of (CSIR-NIIST) sanitizing liquid. Industry Partners ►► Drip type nozzle with less wastage of sanitizer liquid 1) Tachlog Pvt. Ltd. ►► 1 Litre storage capacity with refilling option. (for Indoor Unit) 2) Cabeio Technologies ►► Low power consumption (2W). Can be operated in 110-240V AC/9V battery for Palm Safe unit and the (for Outdoor Unit) outdoor unit. 31 ►► Can be used with 8 hours of power backup. ►► Device can be used for dispensing various sanitizing liquids such as gels, foams or soap solution. ►► Provided with sanitizer level indicator and power indicator LEDs. ►► Table top/wall mount installation type model with sleek design. ►► Suitable for indoor as well as outdoor applications.

CSIR Technologies for COVID-19 Mitigation Swabee-Floor/kitchen/labtop Electronic Devices Disinfectant ►► Broad-spectrum anti-microbial formulation. ►► Contains herbal bio-actives. ►► Safe, non-toxic and non-irritants to skin. Laboratory/Institute Industry Partner Bhartiya Agrow Pharma Pvt. Ltd. CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP) UV-Clean Disinfecting Unit (λ-FLASHBOX) Laboratory/Institute CSIR-National Institute ►► λ-FLASHBOX is a disinfecting unit for everyday For Interdisciplinary accessories to significantly reduce the transmission risk Science & Technology of microbes. (CSIR-NIIST) ►► It follows non-chemical approach to pathogen Industry Partner disinfection. λ-FLASHBOX is a disinfecting unit that Panch-Tatva uses UV-C light (λ =254 nm) to destroy microorganisms, Technologists & including bacteria, virus, protest and fungus/mold Services (effective UVC dose > 80%). ►► This unit can be used for disinfection of commonly used accessories such as electronic gadgets (mobile, watches, wireless gadgets), stationery items, metallic items, paper, plastic/leather accessories (wallets, currency, key, spectacles, bags etc.), PPEs (mask, gloves, etc) and much more. ►► λ-FLASHBOX kills 99.9 % of pathogens on high-touch surfaces within a short period of time (~ 5 min) without use of any chemicals and thus not causing any secondary pollution. ►► Unit is customized with a digital controller which auto-powers the unit while a scheduled cleaning cycle is in progress. ►► λ-FLASHBOX can also be operated by smart phone (android/IOS). ►► Installation is simple, haslow-maintenance and can be easilty and quickly deployed. ►► Can be used in various places like offices, residence, hospital, quarantine centres, bank, post offices, laboratories, super market/shopping malls etc. 32

CSIR Technologies for COVID-19 Mitigation In addition to the above, the following CSIR labs also have the processes and technologies ready for manufacture of dispensers and disinfectants that are open for industry partnership. Lab Dispenser and Disinfectant USP CSIR-CLRI Uses low cost sensors and raw materials available in the market. CSIR-CECRI Homemade, simple, portable and cost- effective automatic hand sanitizer dispenser fabricated for the application of touch-free dispensing of 2-3 ml (palm-full) of sanitizer solution. CSIR-CMERI Battery Powered Disinfectant Sprayer (BPDS) used for the deactivating or killing pathogenic microorganism present on surface or in the environment by spraying water mist with soluble chemical disinfection mist. CSIR-NEERI Bench Scale Air Purification Scrubber (BAPS) facility for COVID-19 Impacted Areas : Bench scale portable air purifier for particulates and bound bio aerosols. It is simple, easy to operate, low cost, and low power consumption. CSIR-CIMAP Cleangerm: A Natural Aromatic Floor Cleaner contains unique combination of essential oils. It has long-lasting lemon-fresh aroma provides a pleasant atmosphere and is acid and phenol-free formulation. 33

CSIR Technologies for COVID-19 Mitigation CSIR-CECRI Coconut oil-based soap solution has been developd which can be used to sanitize our hands from a wide range of disease-causing agents or pathogens. CSIR-CSMCRI Disinfection chamber for PPEs has been developed which aids in the disinfection of face mask, face shields. CSIR-CECRI A process for the electrochemical preparation of sodium hypochlorite (1.0 % NaOCl) disinfectant from common salt has been developed. The solution is mainly used as a disinfectant in public places and hospitals to kill bacteria, fungi and virus. This is green technology with no chemical effluent for disposal. CSIR-CLRI Foot Operated Hand Sanitizer/Liquid Soap Dispenser is ergonomically compatible. It is made up of the steel and plastic materials. It has foot-pedal aligned with the elevated angle and is user-friendly. CSIR-CLRI Foot Operated Water Taps and Drinking Water Dispenser for 25 Litre Bottled Water. It has been developed to avoid the touching of water taps in common areas such as canteens and rest rooms. 34

CSIR-IMMT CSIR Technologies for COVID-19 Mitigation Herbal disinfectant can be used for cleaning surfaces including floor surfaces. CSIR-CEERI Multi-wavelength UV Source for Killing CSIR-CMERI Pathogens in Real Time (MUKT) is a CSIR-CMERI plasma-UV based electronic easy-to-use CSIR-IMMT pathogen inactivation system designed for its multi-purpose and diverse applications in medical, domestic, food and grocery stores. There are two versions of MUKT, namely MUKT Portable Version and MUKT Handheld Version. The systems are easy to operate with normal AC power supply. A pneumatically operated mobile indoor disinfection (POMID) unit has been developed which can be used for deactivation or killing of pathogenic microorganisms present inside a chamber like rooms, halls, building corridors spring mist of water having chemical disinfectants A portable touch free soap-cum-water dispensing system - compact version has been devleoped. When a person approaches the dispenser, a predefined amount of soap (approx. 5ml) will be dispensed from the tap After rubbing his/her hands for twenty (20) seconds, clean water is dispensed from the same tap. The touch-less hand sanitizer is a contactless machine that uses a low cost sensor and motor system to push and release the dispenser top. When the hand is brought nearer to the dispenser, the required amount of liquid is falls on the palm. 35

CSIR Technologies for COVID-19 Mitigation CSIR-CMERI A tractor mounted road ranitizing unit has been developed that can be deployed in long stretches of highways, vicinity of toll plazas etc. where there is a massive volume of traffic and good chance of infection spreading. CSIR-IMMT The UV Disinfectant has been developed with 125 W UV bulb and a rotating base fitted with a shutter door to disinfect personal belongings like masks, key rings, currencies, hanky, tissue, papers, bills etc. and other objects. CSIR-CEERI UV-C based sanitizer system has been developed for disinfecting fomites and other surfaces. It has a uniquely design has the UV-C lamps maintains uniform intensity throughout the chamber. The system is capable of disinfecting the exposed objects in ~2 minutes. It is equipped with safety switch to ensure automatic switching off of lamp in case door is opened during operation to avoid UV exposure risk. Hand Sanitizers Even as the pandemic made its appearance, it was realized that preventing the spread of the highly infectious virus is essential. Social distancing, washing hands frequently and using hand-sanitizers have been very widely advocated. This led to a heavy demand for hand-sanitizers which in turn caused scarcity of the hand-sanitizers. Many CSIR laboratories and institutes stepped in and in accordance with the WHO guidelines, thousands of litres of much-needed lab-scale hand sanitizers were prepared and distributed to not only its own staff but also to the local administration, health-care professionals, police personnel and so on. Many labs also innovated on the formulations by augmenting it with moisturizing agents and fortifying it herbal and aromatic compounds. Many labs have transferred their improved processes to industry partners. 36

CSIR Technologies for COVID-19 Mitigation Alcohol Based Hand Sanitizer Gel ►► Has potential herbal antimicrobial compounds along with isopropyl alcohol (IPA). ►► Prepared as per the guidelines of World Health Organization. ►► Keeps hands moisturized. ►► Rinse Free and Non sticky. ►► Self-drying gel with soothing effects. ►► Dermatologically tested. Laboratory/Institute Industry Partners 1) Satguru Biologicals Pvt. Ltd. CSIR-National Botanical Research Institute 2) Parashar Agrotech Bio(P) Ltd. (CSIR-NBRI) Alcohol Based Liquid Hand Industry Partners Sanitizer 1) Amar Pharmaceuticals & labs ►► Product is based on an indigenous formula, (India) Pvt. Ltd. prepared in compliance with the AYUSH 2) Fervid Healthcare Pvt. Ltd. guidelines of Govt. of India. 37 ►► Takes care of the moisture content of the hand. ►► Pleasant fragrance through added essential oils. Laboratory/Institute CSIR-National Botanical Research Institute (CSIR-NBRI)

CSIR Technologies for COVID-19 Mitigation Hand Rub Sanitizer ►► Sanitizer based on ethanol/isopropyl alcohol. Laboratory/Institute ►► Gel free and allergen free solution. ►► Prepared as per WHO formulation. CSIR-Indian Institute of Toxicological Research (CSIR-IITR) Hand Sanitizer @ CSIR-CIMAP Industry Partner ASPL Green Ventures (P) Ltd ►► Broad-spectrum anti-microbial sanitizer. Laboratory/Institute ►► The formulation is effective against CSIR-Central Institute of maximum harmful pathogens. Medicinal and Aromatic Plants (CSIR-CIMAP) ►► Sanitizer contains herbal bio-actives. Industry Partners ►► Cost-effective product. 1) Rako Industries 2) Being Arogyam Herbals Pvt. Ltd. ►► The formulation is safe and non-irritant to 3) Sai International human skin of all the age groups. 4) Happi Key 5) B Care Sure Life Cure LLP ►► The technology has been approved by Department of AYUSH, Govt. of UP for Laboratory/Institute manufacturing and sale. CSIR-Institute of Himalayan Bioresource Technology (CSIR- Hand Sanitizer @ CSIR-IHBT IHBT) ►► Ingredients include alcohol (ethanol/ Industry Partners isopropyl), glycerin and hydrogen 1) A B Scientific Solutions peroxide concentration as per WHO 2) Sandeep Kumar & Guidelines. Company ►► Also contains natural aroma and tea 3) Baijnath Pharmaceuticals constituents. Pvt. Ltd. ►► Importantly, parabens, triclosan, 4) Nature Green Chamba synthetic fragrances, and phthalates have not been added, which Herbs otherwise are harmful in long term 5) VLCare Health and frequent use. 6) Mount Leaf ►► It is a moisturizing formulation that helps in instant reduction of infectious agents from our hands. 38