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Curso Ciências da Longevidade Humana men with adult-onset GH deficiency. J Clin hormone replacement on physical perfor- Endocrinol Metab. 2000 Mar;85(3):970-6. mance and body composition in GH deficient adults. Clin Endocrinol (Oxf). 1999 › 145. Brixen K, Hansen TB, Hauge E, Vahl N, Jul;51(1):53-60. Jørgensen JO, Christiansen JS, Mosekilde L, Hagen C, Melsen F. Growth hormone › 152. Gibney J, Wallace JD, Spinks T, Schnorr treatment in adults with adult-onset L, Ranicar A, Cuneo RC, Lockhart S, Burnand growth hormone deficiency increases KG, Salomon F + Sonksen PH, Russell-Jones iliac crest trabecular bone turnover: a D. The effects of 10 years of recombinant 1-year, double-blind, randomized, placebo- human growth hormone (GH) in adult -controlled study. J Bone Miner Res. 2000 GH-deficient patients. J Clin Endocrinol Feb;15(2):293-300. Metab. 1999 Aug;84(8):2596-602. › 146. Kousta E, Chrisoulidou A, Lawrence › 153. Johansson AG. Gender difference in NJ, Anyaoku V, Al-Shoumer KA, Johnston growth hormone response in adults. J DG. The effects of growth hormone replace- Endocrinol Invest. 1999;22(5 Suppl):58-60. ment therapy on overnight metabolic fuels in hypopituitary patients. Clin Endocrinol › 154. Soares CN1, Musolino NR, Cunha Neto (Oxf). 2000 Jan;52(1):17-24. M, Caires MA, Rosenthal MC, Camargo CP, Bronstein MD. Impact of recombinant › 147. Woodhouse LJ, Asa SL, Thomas SG, Ezzat human growth hormone (RH-GH) treatment S. Measures of submaximal aerobic perfor- on psychiatric, neuropsychological and mance evaluate and predict functional clinical profiles of GH deficient adults. A response to growth hormone (GH) treatment placebo-controlled trial. Arq Neuropsiquiatr. in GH-deficient adults. J Clin Endocrinol 1999 Jun;57(2A):182-9. Metab. 1999 Dec;84(12):4570-7. › 155. Rosenfalck AM, Fisker S, Hilsted J, › 148. Pedersen SB, Kristensen K, Fisker S, Dinesen B, Vølund A, Jørgensen JO, Chris- Jørgensen JO, Christiansen JS, Richelsen tiansen JS, Madsbad S. The effect of the B. Regulation of uncoupling protein-2 and deterioration of insulin sensitivity on -3 by growth hormone in skeletal muscle beta-cell function in growth-hormone-de- and adipose tissue in growth hormone-de- ficient adults following 4-month growth ficient adults. J Clin Endocrinol Metab.1999 hormone replacement therapy. Growth Nov;84(11):4073-8. Horm IGF Res. 1999 Apr;9(2):96-105. › 149. Gómez Sáez JM, Gómez Arnaiz N, › 156. Florkowski CM, Barnard R, Livesey JH, Soler Ramón J. [Changes in body compo- Veveris T, Espiner EA, Donald RA. Growth sition in adult patients with hypopituita- hormone binding protein correlates strongly rism after substitutive treatment with with leptin and percentage body fat in growth hormone]. Med Clin (Barc). 1999 Sep GH-deficient adults, is increased by GH repla- 11;113(7):246-9. cement but does not predict IGF-I response. Growth Horm IGF Res. 1999 Feb;9(1):35-40. › 150. Christ ER, Cummings MH, Lumb PJ, Crook MA, Sönksen PH, Russell-Jones DL. › 157. Leese GP, Wallymahmed M, VanHey- Growth hormone (GH) replacement therapy ningen C, Tames F + Wieringa G, MacFarlane reduces serum sialic acid concentrations in IA. HDL-cholesterol reductions associated adults with GH-deficiency: a double-blind with adult growth hormone replacement. placebo-controlled study. Clin Endocrinol Clin Endocrinol (Oxf). 1998 Nov;49(5):673- (Oxf). 1999 Aug;51(2):173-9. 7.158. Roelen CA, Koppeschaar HP, de Vries WR, Doerga ME, Snel YE, Bol E, Zelissen PM, › 151. Rodríguez-Arnao J, Jabbar A, Fulcher Thijssen JH, Blankenstein MA. High-affi- K, Besser GM, Ross RJ. Effects of growth nity growth hormone (GH)-binding protein 208

Academia Longevidade Saudável (GHBP), body fat mass, and insulin-like growth hormone deficiency. J Endocrinol growth factor-binding protein-3 predict Invest. 1998 Jul-Aug;21(7):423-7. the GHBP response to GH therapy in adult GH deficiency syndrome. Metabolism. 1999 › 165. Baum HB, Katznelson L, Sherman Mar;48(3):314-8. JC, Biller BM, Hayden DL, Schoenfeld DA, Cannistraro KE, Klibanski A. Effects of › 159. Møller J, Fisker S, Rosenfalck AM, physiological growth hormone (GH) therapy Frandsen E, Jørgensen JO, Hilsted J, Chris- on cognition and quality of life in patients tiansen JS. Long-term effects of growt with adult-onset GH deficiency. J Clin hormone (GH) on body fluid distribution Endocrinol Metab. 1998 Sep;83(9):3184-9. in GH deficient adults: a four months double blind placebo controlled trial. Eur J › 166. Vahl N, Jørgensen JO, Hansen TB, Endocrinol. 1999 Jan;140(1):11-6. Klausen IB, Jurik AG, Hagen C, Chris- tiansen JS. The favourable effects of growth › 160. Bell W, Davies JS, Evans WD, Scanlon hormone (GH) substitution on hypercholes- MF. Strength and its relationship to changes terolaemia in GH-deficient adults are not in fat-free mass, total body potassium, total associated with concomitant reductions in body water and IGF-1 in adults with growth adiposity. A 12 month placebo-controlled hormone deficiency: effect of treatment study. Int J Obes RelatMetab Disord. 1998 with growth hormone. Ann Hum Biol. 1999 Jun;22(6):529-36. Jan-Feb;26(1):63-78. › 167. Fisker S, Vahl N, Hansen TB, Jørgensen › 161. Christ ER, Cummings MH, Albany JO, Hagen C, Orskov H, Christiansen JS. E, Umpleby AM, Lumb PJ, Wierzbicki AS, Growth hormone (GH) substitution for Naoumova RP, Boroujerdi MA, Sönksen one year normalizes elevated GH-bin- PH, Russell-Jones DL. Effects of growth ding protein levels in GH-deficient adults hormone (GH) replacement therapy on very secondary to a reduction in body fat. A place- low density lipoprotein apolipoprotein B100 bo-controlled trial. Growth Horm IGF Res. kinetics in patients with adult GH deficiency: 1998 Apr;8(2):105-12. a stable isotope study. J Clin Endocrinol Metab. 1999 Jan;84(1):307-16 › 168. Rodríguez-Arnao J, James I, Jabbar A, Trainer PJ, Perrett D, Besser GM, Ross › 162. Walker BR, Andrew R, MacLeod KM, RJ. Serum collagen crosslinks as markers Padfield PL. Growth hormone replacement of bone turn-over during GH replacement inhibits renal and hepatic 11 beta-hydro- therapy in growth hormone deficient adults. xys-teroid dehydrogenases in ACTH-defi- Clin Endocrinol (Oxf). 1998 Apr;48(4):455-62. cient patients. Clin Endocrinol (Oxf). 1998 Aug;49(2):257-63. › 169. Juul A, Andersson AM, Pedersen SA, Jørgensen JO, Christiansen JS, Groome NP, › 163. Gullestad L, Birkeland K, Bjønerheim Skakkebaek NE. Effects of growth hormone R, Djøseland O, Trygstad O, Simonsen S. replacement therapy on IGF-related parame- Exercise capacity and hormonal response ters and on the pituitary-gonadal axis in in adults with childhood onset growth GH-deficient males. A double-blind, place- hormone deficiency during long-term bo-controlled crossover study. Horm Res. somatropin treatment. Growth Horm IGF 1998;49(6):269-78 Res. 1998 Oct;8(5):377-84. › 170. Juul A, Andersson AM, Pedersen SA, › 164. Meineri I, Andreani O, Sanna R, Jørgensen JO, Christiansen JS, Groome NP, Aglialoro A, Bottino G, Giusti M. Effect of Skakkebaek NE. Effects of growth hormone low-dosage recombinant human growth replacement therapy on IGF-related parame- hormone therapy on pulmonary function ters and on the pituitary-gonadal axis in in hypopituitary patients with adult-onset GH-deficient males. A double-blind, place- 209

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Curso Ciências da Longevidade Humana factor-1 in oligozoospermia. Fertil Steril. › 448. Bergh C, Hillensjö T, Wikland M, Nilsson 1996 Aug;66(2):305-11. L, Borg G, Hamberger L. Adjuvant growth hormone treatment during in vitro fertili- › 441. Ovesen P, Jørgensen JO, Ingerslev J, zation: a randomized, placebo-controlled Ho KK, Orskov H, Christiansen JS. Growth study. Fertil Steril. 1994 Jul;62(1):113-20. hormone treatment of subfertile males. Fertil Steril. 1996 Aug;66(2):292-8. › 449. Hughes SM, Huang ZH, Morris ID, Matson PL, Buck P, Lieberman BA. A › 442. Cotreatment with growth hormone double-blind cross-over controlled study and gonadotropin for ovulation induction in to evaluate the effect of human biosynthetic hypogonadotropic patients: a prospective, growth hormone on ovarian stimulation in randomized, placebo-controlled, dose-res- previous poor responders to in-vitro ferti- ponse study. European and Australian Multi- lization. Hum Reprod. 1994 Jan;9(1):13-8. center Study. Fertil Steril. 1995 Nov;64(5):917- 23. [No authors listed] Poor responders to › 450. Younis JS, Ezra Y, Brzezinnski A, Fibich T, IVF (in vitro fertilization). Schenker JG, Laufer N. The effect of growth hormone on granulosa cell function during › 443. Tesarik J, Hazout A, Mendoza C. Impro- in-vitro fertilization. Hum Reprod. 1993 vement of delivery and live birth rates after Oct;8(10):1588-92. ICSI in women aged >40 years by ovarian co-stimulation with growth hormone. Hum › 451. Huang ZH, Baxter RC, Hughes SM, Reprod. 2005 Sep;20(9):2536-41. Matson PL, Lieberman BA, Morris ID. Supplementary growth hormone treatment › 444. Rabinovici J, Cataldo NA, Dandekar P, of women with poor ovarian response to Rosenthal SM, Gargosky SE, Gesundheit N, exogenous gonadotrophins: changes in Martin MC. Adjunctive growth hormone serum and follicular fluid insulin-like growth during ovarian hyperstimulation increases factor-1 (IGF-1) and IGF binding protein-3 levels of insulin-like growth factor binding (IGFBP-3). Hum Reprod. 1993 Jun;8(6):850-7. proteins in follicular fluid: a randomized, placebo-controlled, cross-over study. J Clin › 452. Tapanainen J, Martikainen H, Vouti- Endocrinol Metab. 1997 Apr;82(4):1171-6. lainen R, Orava M, Ruokonen A, Rönnberg L. Effect of growth hormone administration › 445. Suikkari A, MacLachlan V, Koistinen R, on human ovarian function and steroido- Seppälä M, Healy D. Double-blind placebo genic gene expression in granulosa-luteal controlled study: human biosynthetic cells. Fertil Steril. 1992 Oct;58(4):726-32. growth hormone for assisted reproductive technology. Fertil Steril. 1996 Apr;65(4):800-5. › 453. Younis JS, Simon A, Koren R, Dorembus D, Schenker JG, Laufer N. The effect of › 446. Homburg R, Levy T, Ben-Rafael Z. growth hormone supplementation on in Adjuvant growth hormone for induction vitro fertilization outcome: a prospective of ovulation with gonadotrophin-releasing randomized placebo-controlled double-blind hormone agonist and gonadotrophins in study. Fertil Steril. 1992 Sep;58(3):575-80. polycystic ovary syndrome: a randomized, double-blind, placebo controlled trial. Hum › 454. Tapanainen J, Martikainen H, Vouti- Reprod. 1995 Oct;10(10):2550-3. lainen R, Orava M, Ruokonen A, Rönnberg L. Effect of growth hormone administration › 447. Dor J, Seidman DS, Amudai E, Bider D, on human ovarian function and steroido- Levran D, Mashiach S. Adjuvant growth genic gene expression in granulosa-luteal hormone therapy in poor responders to cells. Fertil Steril. 1992 Oct;58(4):726-32. in-vitro fertilization: a prospective rando- mized placebo-controlled double-blind study. › 455. Owen EJ, Shoham Z, Mason BA, Oster- Hum Reprod. 1995 Jan;10(1):40-3. gaard H, Jacobs HS. Cotreatment with 230

Academia Longevidade Saudável growth hormone, after pituitary suppres- › 462. Walvoord EC, de la Peña A, Park S, sion, for ovarian stimulation in in vitro Silverman B, Cuttler L, Rose SR, Cutler fertilization: a randomized, double-blind, G, Drop S, Chipman JJ. Inhaled growth placebo-control trial. Fertil Steril. 1991 hormone (GH) compared with subcuta- Dec;56(6):1104-10. neous GH in children with GH deficiency: pharmacokinetics, pharmacodynamics, › 456. Tapanainen J, Rönnberg L, Martikainen and safety. J Clin Endocrinol Metab. 2009 H, Reinilä M, Koistinen R, Seppälä M. Short Jun;94(6):2052-9. doi: 10.1210/jc.2008-1897. and long term effects of growth hormone on circulating levels of insulin-like growth › 463. Mauras N, Pescovitz OH, Allada V, factor-I (IGF-I), IGF-binding protein-1, and Messig M, Wajnrajch MP, Lippe B; Transi- insulin: a placebo-controlled study. J Clin tion Study Group. Limited efficacy of Endocrinol Metab. 1991 Jul;73(1):71-4. growth hormone (GH) during transition of GH-deficient patients from adolescence to › 457. Owen EJ, West C, Mason BA, Jacobs adulthood: a phase III multicenter, double- HS. Co-treatment with growth hormone -blind, randomized two-year trial. J Clin of sub-optimal responders in IVF-ET. Hum Endocrinol Metab. 2005 Jul;90(7):3946-55. Reprod. 1991 Apr;6(4):524-8. › 464. Smith MO, Shaywitz SE, Shaywitz › 458. Homburg R, West C, Torresani T, Jacobs BA, Gertner JM, Raskin LA, Gelwan HS. Cotreatment with human growth EM. Exogenous growth hormone levels hormone and gonadotropins for induction predict attentional performance: a preli- of ovulation: a controlled clinical trial. Fertil minary report. J Dev Behav Pediatr. 1985 Steril. 1990 Feb;53(2):254-60. Oct;6(5):273-8. › Turner syndrome adults › Growth hormone therapy on children with disorder: 43 placebo-controlled studies (48 › 459. Trolle C, Hjerrild B, Mortensen KH, in total as 5 other placebo-controlled trials Knorr S, Søndergaard HM, Christiansen JS, are with both children and adults) Gravholt CH. Low myocardial glucose uptake in Turner syndrome is unaffected by growth › Short stature-children hormone: a randomized, placebo-controlled FDG-PET study. Clin Endocrinol (Oxf). 2015 › 465. Quigley CA, Gill AM, Crowe BJ, Robling Jul;83(1):133-40. K, Chipman JJ, Rose SR, Ross JL, Cassorla FG, Wolka AM, Wit JM, Rekers-Mombarg › 460. Taback SP, Van Vliet G. Health-related LT, Cutler GB Jr. Safety of growth hormone quality of life of young adults with Turner treatment in pediatric patients with idiopa- syndrome following a long-term randomized thic short stature. J Clin Endocrinol Metab. controlled trial of recombinant human 2005 Sep;90(9):5188-96. growth hormone. BMC Pediatr. 2011 May 29;11:49. › 466. Ross JL, Sandberg DE, Rose SR, Leschek EW, Baron J, Chipman JJ, Cassorla FG, › 461. Ross JL, Feuillan P, Kushner H, Roeltgen Quigley CA, Crowe BJ, Roberts K, Cutler GB D, Cutler GB Jr. Absence of growth hormone Jr. Psychological adaptation in children with effects on cognitive function in girls with idiopathic short stature treated with growth Turner syndrome. J Clin Endocrinol Metab. hormone or placebo. J Clin Endocrinol Metab. 1997 Jun;82(6):18147. 2004 Oct;89(10):4873-8. › Growth hormone therapy on growth hormo- › 467. Leschek EW, Rose SR, Yanovski JA, ne-deficient children: 46 placebo-controlled Troendle JF + Quigley CA, Chipman JJ, studies (50 with mixed studies) Crowe BJ, Ross JL, Cassorla FG, Blum WF + Cutler GB Jr, Baron J; National Institute of › GH deficient - children/adolescents 231

Curso Ciências da Longevidade Humana Child Health and Human Development-Eli borative Study Group. Pediatr Nephrol. 1995 Lilly & Co. Growth Hormone Collaborative Aug;9(4):451-7. Group. Effect of growth hormone treatment on adult height in peripubertal children with › 474. Rose SR, Leong GM, Yanovski JA, Blum D, idiopathic short stature: a randomized, Heavner G, Barnes KM, Chipman JJ, Dichek double-blind, placebo-controlled trial. J Clin HL, Jacobsen J, Klein KE, et al. Thyroid Endocrinol Metab. 2004 Jul;89(7):3140-8. function in non-growth hormone-deficient short children during a placebo-controlled › 468. Saha MT, Haapasaari J, Hannula S, double blind trial of recombinant growth Sarna S, Lenko HL. Growth hormone is hormone therapy. J Clin Endocrinol Metab. effective in the treatment of severe growth 1995 Jan;80(1):320-4. retardation in children with juvenile chronic arthritis. Double blind placebo-con- › 475. Chatelain P, Job JC, Blanchard J, Ducret trolled followup study. J Rheumatol. 2004 JP, Oliver M, Sagnard L, Vanderschueren- Jul;31(7):1413-7. -Lodeweyckx M. Dose-dependent catch-up growth after 2 years of growth hormone › 469. Haqq AM, Stadler DD, Jackson RH, treatment in intrauterine growth-retarded Rosenfeld RG, Purnell JQ, LaFranchi SH. children. Belgian and French Pediatric Effects of growth hormone on pulmonary Clinics and Sanofi-Choay (France). J Clin function, sleep quality, behavior, cognition, Endocrinol Metab. 1994 Jun;78(6):1454-60. growth velocity, body composition, and resting energy expenditu-re in Prader-Willi › 476. Fine RN, Kohaut EC, Brown D, Perlman syndrome. J Clin Endocrinol Metab. 2003 AJ. Growth after recombinant human May;88(5):2206-12. growth hormone treatment in children with chronic renal failure: report of a multicenter › 470. Leschek EW, Troendle JF + Yanovski JA, randomized double-blind placebo-controlled Rose SR, Bernstein DB, Cutler GB Jr, Baron study. Genentech Cooperative Study Group. J. Effect of growth hormone treatment on J Pediatr. 1994 Mar;124(3):374-82. testicular function, puberty, and adrenarche in boys with non-growth hormone-deficient › 477. Boulton TJ, Smith R, Single T. Psychoso- short stature: a randomized, double-blind, cial growth failure: a positive response to placebo-controlled trial. J Pediatr. 2001 growth hormone and placebo. Acta Paediatr. Mar;138(3):406-10. 1992 Apr;81(4):322-5. › 471. Seikaly MG, Brown R, Baum M. The effect › 478. Hokken-Koelega AC, Stijnen T, de Muinck of recombinant human growth hormone in Keizer-Schrama SM, Wit JM, Wolff ED, de children with X-linked hypo-phosphatemia. Jong MC, Donckerwolcke RA, Abbad NC, Pediatrics. 1997 Nov;100(5):879-84. Bot A, Blum WF + et al. Placebo-controlled, double-blind, cross-over trial of growth › 472. Hokken-Koelega AC, Stijnen T, de Jong hormone treatment in prepubertal children RC, Donckerwolcke RA, Groothoff JW, Wolff with chronic renal failure. Lancet. 1991 Sep ED, Blum WF + de Muinck Keizer-Schrama 7;338(8767):585-90. SM, Drop SL. A placebo-controlled, double- -blind trial of growth hormone treatment in Burned children prepubertal children after renal transplant. Kidney Int Suppl. 1996 Jan;53:S128-34. › 479. Branski LK, Herndon DN, Barrow RE, Kulp GA, Klein GL, Suman OE, Przkora R, › 473. Fine RN, Attie KM, Kuntze J, Brown DF Meyer W 3rd, Huang T, Lee JO, Chinkes + Kohaut EC. Recombinant human growth DL, Mlcak RP, Jeschke MG. Randomized hormone in infants and young children with controlled trial to determine the efficacy chronic renal insufficiency. Genentech Colla- of long-term growth hormone treatment in severely burned children. Ann Surg. 2009 Oct;250(4):514-23. 232

Academia Longevidade Saudável › 480. Jeschke MG, Finnerty CC, Kulp GA, growth hormone therapy. Ann Surg. 2001 Przkora R, Mlcak RP, Herndon DN. Combi- Jun;233(6):827-34. nation of recombinant human growth hormone and propranolol decreases hyper- › 488. Jeschke MG, Barrow RE, Herndon DN. metabolism and inflammation in severely Recombinant human growth hormone burned children. Pediatr Crit Care Med. 2008 treatment in pediatric burn patients and its Mar;9(2):209-16. role during the hepatic acute phase response. Crit Care Med. 2000 May;28(5):1578-84. › 481. Przkora R, Herndon DN, Suman OE, Jeschke MG, Meyer WJ, Chinkes DL, Mlcak › 489. Barret JP, Dziewulski P, Jeschke MG, RP, Huang T, Barrow RE. Beneficial effects Wolf SE, Herndon DN. Effects of recombinant of extended growth hormone treatment human growth hormone on the development after hospital discharge in pediatric burn of burn scarring. Plast Reconstr Surg. 1999 patients. Ann Surg. 2006 Jun;243(6):796-801; Sep;104(3):726-9. › 482. Mlcak RP, Suman OE, Murphy K, › 490. Ramirez RJ, Wolf SE, Barrow RE, Herndon DN. Effects of growth hormone on Herndon DN. Growth hormone treatment anthropometric measurements and cardiac in pediatric burns: a safe therapeutic function in children with thermal injury. approach. Ann Surg. 1998 Oct;228(4):439-48. Burns. 2005 Feb;31(1):60-6. › 491. Klein GL, Wolf SE, Langman CB, Rosen › 483. Thomas S, Wolf SE, Chinkes DL, Herndon CJ, Mohan S, Keenan BS, Matin S, Steffen C, DN. Recovery from the hepatic acute phase Nicolai M, Sailer DE, Herndon DN. Effects of response in the severely burned and the therapy with recombinant human growth effects of long-term growth hormone hormone on insulin-like growth factor treatment. Burns. 2004 Nov;30(7):675-9 system components and serum levels of biochemical markers of bone formation › 484. de Oliveira GV, Sanford AP, Murphy KD, in children after severe burn injury. J Clin de Oliveira HM, Wilkins JP, Wu X, Hawkins Endocrinol Metab. 1998 Jan;83(1):21-4. HK, Kitten G, Chinkes DL, Barrow RE, Herndon DN. Growth hormone effects on › 492. Gilpin DA, Barrow RE, Rutan RL, hypertrophic scar formation: a randomized Broemeling L, Herndon DN. Recombinant controlled trial of 62 burned children. Wound human growth hormone accelerates wound Repair Regen. 2004 Jul-Aug;12(4):404-11. healing in children with large cutaneous burns. Ann Surg. 1994 Jul;220(1):19-24. › 485. Wilkins JP, Suman OE, Benjamin DA, Herndon DN. Comparison of self-reported › 493. Herndon DN, Barrow RE, Kunkel KR, and monitored compliance of daily injection Broemeling L, Rutan RL. Effects of recombi- of human growth hormone in burned nant human growth hormone on donor-site children. Burns. 2003 Nov;29(7):697-701. healing in severely burned children. Ann Surg. 1990 Oct;212(4):424-9; discussion 430-1. › 486. Connolly CM, Barrow RE, Chinkes DL, Martinez JA, Herndon DN. Recombi- Turner syndrome - children nant human growth hormone increases thyroid hormone-binding sites in recove- › 494. Taback SP, Van Vliet G. Health-related ring severely burned children. Shock. 2003 quality of life of young adults with Turner May;19(5):399-403. syndrome following a long-term randomized controlled trial of recombinant human › 487. Hart DW, Herndon DN, Klein G, Lee growth hormone. BMC Pediatr. 2011 May SB, Celis M, Mohan S, Chinkes DL, Wolf 29;11:49. SE. Attenuation of posttraumatic muscle catabolism and osteopenia by long-term › 495. Ross JL, Quigley CA, Cao D, Feuillan P, Kowal K, Chipman JJ, Cutler GB Jr. Growth 233

Curso Ciências da Longevidade Humana hormone plus childhood low-dose estrogen factors and their binding proteins in adult in Turner’s syndrome. N Engl JMed. 2011 Mar hemodialysis patients treated with recombi- nant human growth hormone. Clin Nephrol. 31;364(13):1230-42. doi: 10.1056/ 1999 Aug;52(2):103-9. NEJMoa1005669. › 503. Fine RN, Brown DF + Kuntze J, Wooster › 496. Ross JL. Effects of growth hormone on P, Kohaut EE. Growth after discontinuation cognitive function. Horm Res. 2005;64 Suppl of recombinant human growth hormone 3:89-94. Epub 2006 Jan 20. therapy in children with chronic renal insuf- ficiency. The Genentech Cooperative Study › 497. Gravholt CH, Hjerrild BE, Naeraa RW, Group. J Pediatr. 1996 Dec;129(6):883-91. Engbaek F + Mosekilde L, Christiansen JS. Effect of growth hormone and 17beta-oes- Surgery- children tradiol treatment on metabolism and body composition in girls with Turner syndrome. › 504. Letton RW, Chwals WJ, Jamie A, Charles Clin Endocrinol (Oxf). 2005 May;62(5):616-22. B. Neonatal lipid utilization increases with injury severity: recombinant human growth › 498. Gravholt CH, Naeraa RW, Brixen hormone versus placebo. J Pediatr Surg. K, Kastrup KW, Mosekilde L, Jørgensen 1996Aug;31(8):1068-72; discussion 1072-4 JO, Christiansen JS. Short-term growth hormone treatment in girls with Turner Liver and Crohn’s disease – children only syndrome decreases fat mass and insulin sensitivity: a randomized, double-blind, › 505. Calenda KA, Schornagel IL, Sadeghi- placebo-controlled, crossover study. Pedia- -Nejad A, Grand RJ. Effect of recombinant trics. 2002 Nov;110(5):889-96. growth hormone treatment on children with Crohn’s disease and short stature: › 499. Quigley CA, Crowe BJ, Anglin DG, a pilot study. Inflamm Bowel Dis. 2005 Chipman JJ. Growth hormone and low May;11(5):435-41. dose estrogen in Turner syndrome: results of a United States multi-center trial to › 506. Greer RM, Quirk P, Cleghorn GJ, near-final height. J Clin Endocrinol Metab. Shepherd RW. Growth hormone resis- 2002 May;87(5):2033-41. tance and somatomedins in children with end-stage liver disease awaiting transplan- › 500. Buchanan CR, Law CM, Milner RD. tation. J Pediatr Gastroenterol Nutr. 1998 Growth hormone in short, slowly growing Aug;27(2):148-54. children and those with Turner’s syndrome. Arch Dis Child. 1987 Sep;62(9):912-6. Cystic fibrosis children Obesity - children › 507. Schnabel D, Grasemann C, Staab D, Wollmann H, Ratjen F; German Cystic › 501. Slattery M, Bredella MA, Stanley T, Fibrosis Growth Hormone Study Group. Torriani M, Misra M. Effects of recombinant A multicenter, randomized, double-blind, human growth hormone (rhGH) adminis- placebo-controlled trial to evaluate the tration on body composition and cardiovas- metabolic and respiratory effects of growth cular risk factors in obese adolescent girls. hormone in children with cystic fibrosis. Int J Pediatr Endocrinol. 2014;2014(1):22. Pediatrics. 2007 Jun;119(6):e1230-8. Kidney failure - children Edema disappears with GH dose reduction › 502. Jensen PB, Hansen TB, Frystyk J, › 508. Wüster C, Melchinger U, Eversmann T, Ladefoged SD, Pedersen FB, Christiansen Hensen J, Kann P, von zur Mühlen A, Ranke JS. Growth hormone, insulin-like growth MB, Schmeil H, Steinkamp H, Tuschy U. 234

Academia Longevidade Saudável Reduced incidence of side-effects of growth Drug Administration for phosphodies- hormone substitution in 404 patients with terase type-5 inhibitors. J Sex Med. 2012 hypophyseal insufficiency. Results of a multi- Jan;9(1):265-70. (10-year analysis of adverse center indications study]. Med Klin (Munich). event reports to the Food and Drug Adminis- 1998 Oct 15;93(10):585-91 tration . Overall, 14,818 adverse events (AEs) were reported for sildenafil. There were 1,824 › 509. Abs R, Bengtsson BA, Hernberg-Stâhl (12.3%) reported deaths, and reports of E, Monson JP, Tauber JP, Wilton P, Wüster cardiovascular AEs numbered 2,406 (16.2%). C. GH replacement in 1034 growth hormone … Only 10% of AE reports sent to the FDA for deficient hypopituitary adults: demogra- PDE5-i were from pharmaceutical manufac- phic and clinical characteristics, dosing turers. Reports of deaths associated with and safety. Clin Endocrinol (Oxf). 1999 PDE5-i remain around 5% of total reported. Jun;50(6):703-13. › 510. Verhelst J, Abs R, Vandeweghe M, Mockel J, Legros JJ, Copinschi G, Mahler C, Velke- niers B, Vanhaelst L, Van Aelst A, De Rijdt D, Stevenaert A, Beckers A. Two years of replacement therapy in adults with growth hormone deficiency. Clin Endocrinol (Oxf). 1997 Oct;47(4):485-94 Insulin sensitivity: greater improvement with smaller doses of GH treatment › 511. Yuen KC, Dunger DB. Persisting effects on fasting glucose levels and insulin sensi- tivity after 6 months of discontinuation of a very low-dose GH therapy in adults with severe GH deficiency. Clin Endocrinol (Oxf). 2006 May;64(5):549-55 (the Low 0.1 mg/day GH dose has benefical effects on fasting glucose levels and insulin sensitivity, which persist after 6 months of discontinuation of therapy, which high doses of 0.5 mg/day have Viagra: first study and adverse events, including mortality and other › 512. Boolell M, Gepi-Attee S, Gingell JC, Allen MJ. Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br J Urol. 1996 Aug;78(2):257-61. (Twelve patients (aged 36-63 years) with male erectile dysfunc- tion. double-blind, randomized, placebo- -controlled, crossover study) › 513. Lowe G, Costabile RA. 10-Year analysis of adverse event reports to the Food and 235

Curso Ciências da Longevidade Humana ANEXO 1 – NÍVEIS ÓTIMOS Abordagem Terapêutica Disbiose, Inflamação, Resistência insulínica, Energia, Vitamina D Déficit Melatonina Avaliar cortisol Déficit Cortisol antes de repor Déficit T4/T3 Avaliar cortisol antes de repor Avaliar cortisol Déficit DHEA antes de repor Demais Testo, E2, Progesterona, Déficits GH, Pregnenolona Abordagem Terapêutica 1a Consulta: 2a Consulta/Retorno: 3a Consulta 3a Consulta: 3a Consulta: 4a consulta QP, Clínica, Exame (90 dias): Considerar (+/- 180 dias): Exames (+/- 30d). abordar déficits Solicitar exames revisão clínica e Físico, Solicitar Corrigir/avaliar: Corrigir déficits testo, “menores” follow up ajuste de programa déficit Vit D, cortisol, e2, progesterona. Exames. DHEA, t4/t3 + foco (alterados iniciais), retorno + 90 dias Conduta: na QP Disbiose, Detox, Energia. 236

www.longevidadesaudavel.com.br Disbiose intestinal Sintomas GI (distensão, constipação, intolerância a determinados alimentos) TNF alfa >1 Pre-bioticos + Pró-Bióticos Enzimas digestivas (se a queixa maior for distensão) Glutamina 3g Melatonia!!!! Bariátricos/Balão: Ajuste de dose Pre-bioticos + Pró-Bióticos (1/2 dose) Diarreia crônica pós Pré/Pró-Bióticos: Glutamina 3g 1 mês, modular inflamação e posterior incluir probióticos Inflamação, Resistência Insulínica, Energia Homocisteína>5, PCR US >0,11, Índice de atividade inflamatório, inflamograma >7 Insulina >6, glicemia>85, Hb1ac>5,1 Ácido Úrico >3,5/4 Se anticorpos anti-tireoidianos NEGATIVOS Iodo Metálico 12,5 a 25mg; Se anticorpos POSITIVOS, Iodo Kelpp 1,5 a 6mg/dia Ômega 3, boa proporção 340/180 epa/dha p/grama Ômega 7 210mg 2x ao dia ou 420mg 2x ao dia Glifage XR 500 a 2000mg, Cromo GTF CoQ10 100mg (regular) a 600mg (ICC); D-Ribose 14 a 30g/dia; L-Carnitina até 1.000mg/dia, Mg 400mg Glifage XR: sintomas GI, escalonar dose; deficiência de B12 Ômega 3, ideal liberação entérica Iodo: reavaliar anticorpos e função tireoidiana em 90 dias Glifage XR: diarreia crônica, insuficiência renal, doença hepática Academia Longevidade Saudável • Todos os direitos reservados © 2020. 237 A reprodução e compartilhamento deste material é proibida.

Curso Ciências da Longevidade Humana Melatonina Dosagem na saliva <10 entre as 21:00 e 22:00 Sono não reparador, queixas de insônia, sono sem “sonhos” Jet Lag Bom começo: melatonina 3mg Pessoas mais novas (<45 anos) podem usar menos (1mg) e mais idosos (>65) de 3mg a 6mg. Opção time release Piora do sono, pesadelos, cefaleia matinal – considerar ajustar dose menor ou maior. Avaliar Cortisol antes de repor! Maior dificuldade de ajuste em usuários de benzodiazepínicos. Se despertar noturno, checar curva de cortisol salivar e avaliar aumentar a dose. Déficit Cortisol (FADIGA!!!) Sérico matinal <15 ou >25 (crônico e agudo respectivo) Curva de cortisol em saliva ou curva clínica de fadiga x energia Clínica de cansaço pela manhã, mas pode se manifestar em outros horários. Vontade de consumir alimentos salgados e gordurosos. Agudo: MEV, Polivitamínicos (complexo B, biotina,...) Crônico: hidrocortisona base 10/20mg (distribuir pelos horários de fadiga – curva) Crônico: pode usar adaptógenos (GINSENG COREANO 60, ASHWAGANDHA 250, RHODIOLA ROSEA 60) AVALIAR TIREOIDE – Cortisol e hormônios tireoidianos andam juntos ATENÇÃO: Hidrocortisona base é DIFERENTE de Hidrocortisona Acetato (relação de 1:100 em potência) Atenção à manipulação da hidrocortisona: farmácias com qualidade, erros muito frequentes! Neoplasias prévias ou em curso Gestantes 238