disulfide bridges

disulfide bridges secondary structure • The disulfide bond plays an important role in maintaining the spatial three- dimensional structure of peptides and proteins and the biological activity determined thereby, and is also related to the stability and renaturation of proteins. Analysis of disulfide bonds and free sulfhydryl groups on proteins helps to analyze the high-level structure of proteins to reveal the biological functions of proteins. Disulfide bond analysis can analyze the structural characteristics of protein to improve its degradation stability and prolong its efficacy. The analysis of disulfide bonds in proteins is an important biochemical technology for biotherapeutic drug development projects. Related technical methods can be used to determine the location and content of disulfide bonds of biopharmaceutical proteins or other biological agents, thereby determining the structure and relative molecular content of proteins, and also measuring free thiol groups.

• Creative Proteomics is a biotherapeutic drug partner with rich and professional protein structure research technology. We use first-class experimental equipment and mature experimental technical methods to provide you with reliable one-stop service. The analysis of protein structure characterization information in biopharmaceuticals is an important part of the quality control of peptide and protein biopharmaceuticals. In particular, the ICH Q6B guideline requires the provision of disulfide bond characterization analysis information in protein structures of biopharmaceuticals. We will provide you with comprehensive and GLP / cGMP-compliant N-terminal sequencing analysis service around the ICH guidelines (especially ICH Q6B) and the US FDA issues 'Points to Consider' document. • We Can Provide but Not Limited to: • Analysis of localization of disulfide bonds in proteins • Analysis of the proportion of disulfide bonds in proteins • Analysis of primary structure characteristics of protein • Analysis of free sulfhydryl groups in proteins • Protein molecular mass analysis