International conference on entrepreneurship and sustainability in the digital era (ICESDE) 2018

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 Understanding the Experiential and Behavioral Effects of Health Concern in Thai People Pichcha Viraporn1*, Piya Hirunwat2, and Panita Yimcharoen3 1MBA Student, Graduate School of Business, Assumption University of Thailand 2Faculty member, Graduate School of Business, Assumption University of Thailand 3Faculty member, Graduate School of Business, Assumption University of Thailand *Corresponding author. Email: [email protected] Abstract Thai consumers have begun to be more conscious of their health. This can affect their purchase decision, perceived value, and behavior. It is very important for the marketer to understand how consumers think and how they would want to experience healthy food consumption. The health concern can affect the behavior of consumers in restaurant as well. Many Thai consumers are starting to educate themselves on how to eat healthy food or when they dine out, what should they get. The objective of this study is to investigate the effects of emotions, perceived value and restaurant quality in the relationship between health concern and behavioral intention. The data were collected from 414 respondents who were Thai citizens. The result was collected from non- probability convenience and snowball samplings. The data analysis was done by simple linear regression, multiple linear regression, and t-Test. Keywords: Health Concern, Healthy Food, Values and Behaviors, Behavioral Intention, Emotional Response, Perceived Value, Perceived Quality 50

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 The Factor Influence Customer Intention to Use Cashless Payment System: A Case Study of QR Code Payment System in Bangkok, Thailand Sananporn Punyaratpukdee1*, Rawin Vongurai2, and Kitti Photikitti3 1MBA Student, Graduate School of Business, Assumption University, Thailand 2Faculty member, Graduate School of Business, Assumption University, Thailand 3Faculty member, Graduate School of Business, Assumption University, Thailand *Corresponding author. E-mail: [email protected] Abstract Innovation in technology has a great impact to people’s lives, it helps to facilitate and simplify a business to be more effective. Thai Government currently supports a cashless society and QR Code technology is one of the tools which is easy, fast, safe, and convenience that does not require additional and costly equipment or device which can enhance idea of cashless society. This research has studied on the factors that influence intention to use QR code payment system. The target population is people who have banking application and live in Bangkok area in Thailand. Non-probability convenience and snowball sampling are the method used on data collecting process. To analyze the data, Simple Linear Regression, Multiple Linear Regression and One-way ANOVA have been applied. The result in this research paper show that perceived usefulness, perceived risk and perceived ease of use are significantly influence intention to use QR code payment system. Beside, self-efficacy and perceived risk also significantly influence perceived usefulness of using QR code payment system as well as self-efficacy has significantly influence on perceived ease of use of QR code payment system. Keywords: QR Code Payment, Cashless Payment System, Technology Acceptance Model, Self-efficacy, Perceived Risk, Perceived Ease of Use, Perceived Usefulness, Intention to Use 51

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 Entrepreneurship & Sustainability: A Critique and Retrospective Position Paper John Barnes Bangkok, Thailand - 10260 Email: [email protected] Abstract Entrepreneurship and Sustainability are but two vital ingredients to human progress. Diverse examples are discussed, and it is concluded that the unchecked increasing number of human population along with willful disregard of value (and cost) to the environment, are lacking from contemporary economics and governments local national and internationally. These two factors are largely ignored by the population at large and social leaders must face up to them both, as a matter of urgency, if our species is to survive. This paper draws on secondary data and academic sources to shape discussion, rather than primary data collected through fieldwork. Keywords: Entrepreneurship, Sustainability, World Population, Economic History 52

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 Factors Influencing Consumer Decision Making to Use Quick Response (QR) Code Mobile Payment in Bangkok, Thailand. Niramol Pimarnsawast Bangkok-10250 Thailand Email: [email protected] Abstract At present, technology has become a part of daily routine for everyone .Thailand steps into digital society or Thailand 4.0 following the government’s policy .One of the big change for Thailand 4.0 was Promtpay coming across with QR code mobile payment toward cashless society .Therefore, QR code mobile payment was similar to new channel of payment in Thai society .It gave everyone more choices in cashless payment .This research can help merchant and customer to find another way to get competitive advantage over others if they provided or use QR code mobile payment .The researcher used six independent variables, which including with consumer innovativeness, attitude toward QR code mobile payment, perceived usefulness, perceived security, perceived trust, perceived ease of use and consumer decision making .To study factors influencing consumer decision making to use quick response)QR ( codes mobile payment in Bangkok, Thailand. The simple size was 387 respondents )30 respondents for pre-testing included .(The researcher distributed questionnaire to the people who are interested to use QR code mobile payment in downtown shopping area, Bangkok, which Purposive Sampling, Quota sampling, and Convenience Sampling Method were used. The researcher analyzes the factors influencing by using descriptive analysis and inferential statistic. Furthermore, the study confirms that consumer innovativeness, attitude toward QR code, perceived security, and perceived ease of use influence to use QR code mobile payment in Bangkok, suggesting that the researcher also gives the recommendations to help merchant and customer in using the QR code mobile payment channel to increase customer’s choices for payment toward consumer decision making. Theoretical and practical implications of the findings and future research directions are also discussed. Keywords :Consumer Innovativeness, Attitude, Perceived Ease of Use, Perceived Usefulness, Perceived Security, Perceived Trust, and Consumer Decision Making 53

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 Improving SMEs’ Business Sustainability Through Competitive Intelligence *Shusheel Narula Bangkok, Thailand-10100 *Corresponding author: Email: [email protected] Abstract This paper proposes the conceptual framework for implementing Competitive Intelligence (CI) to enable sustainable growth in Small and Medium Enterprises in Thailand. The research proposes a CI framework that leverages on publicly available financial statement information and market information, as these two sources are readily and regularly available at low cost with minimal and efforts to perform data analysis. Data sourced from financial statement would allow SMEs to gain insights and to quantify levels of relationship into key performance indicators vis a vis competitors and stakeholders, while market information would allow SMEs to monitor local and external operating environment and changes in market trends. With such insights, the CI framework would enhance the decision making process in SMEs, particularly in setting strategic directions and taking tactical actions. The research proposes that CI is conducted continuously as a close-loop process with four key elements, comprising a) data update, analysis and communicate, b) management take/ adjust strategic and tactical plans, c) realign / align target and benchmark and d) monitor plan against benchmarks. Keywords: Small and Medium Enterprises, Competitive Intelligence, Strategic Direction, Financial Statement, Market information 54

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 Impacts of Innovation announcements on SET and MAI stock market index return and volatility between 2012 and 2017 Bancha Rojkittisakul1 and Witsaroot Pariyaprasert2 1Bancha Rojkittisakul, MBA graduate from Assumption University. 2Witsaroot Pariyaprasert, MBA Program Director of Assumption University Email: [email protected] , [email protected] Abstract The purpose of this paper is to examine the announcements, mostly related to mobile phone from Apple, Google, and Samsung, that affect to the stock market return and volatility of the Stock Exchange of Thailand (SET) and Market for Alternative Investment (MAI) index in Thailand. The research adopts the daily data between 1 January 2012 to 20 October 2017 in total 1420 observations. Daily data of announcements are the event dummy variables with the appropriate adjustment for time zone. This paper uses multiple linear regression model to evaluate the return effects, and uses EGARCH (1,1) model to evaluate the return volatility effects. The results show that all innovation announcements have no effect on return of both SET and MAI index. However, only Samsung’s announcements have significant impact on both SET and MAI index by causing higher return volatility. Keywords: Announcements, Event Study, Innovation, Mobile Phone, Stock Return, Stock Volatility, GARCH, EGARCH, regression, SET, MAI. 55

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 Factors Affecting the Automotive Sales: A Case Study of Top 2 Models of a Japanese Automotive Company in Thailand During 2012-2016 Tanjira Puritputtiphan, Witsaroot Pariyaprasert and Nawaporn Vimolphattanatham Emails: [email protected], [email protected], [email protected] Address (for both): Graduate School of Business, Assumption University, Thailand Abstract The purpose of this study is to analyze the effect of some market and macroeconomic factors to monthly sales of the selected top 2 models of a Japanese automotive company in Thailand. The monthly time series data during 2012-2016 are used with multiple-linear regression analysis. This research selected 17 independent variables which consists of 2 variables of macroeconomic factors and 15 market factors. The result of car model 1 shows that there are positive relationships between sales and 2 variables which are spending on events and one-month lag of spending on other advertisement; while there is negative relationship with 3 variables, spending on other advertisement, number of dealers in North region, and number of dealers in Central and East region. The result of car model 2 shows the positive relationship with 3 variables which are spending on other advertisement, spending on customer relationship management (CRM), and number of dealers in Bangkok and Greater Bangkok area; while there are negative relationships with automobile loan interest rate and one-month lag of spending on CRM. The researchers conclude that the macroeconomic factors do not have much effect to sales, except the loan interest rate on the commercial car model. However, sales of both car models were affected mainly by market factors especially the expenditures related to marketing activities. Keywords: Customer Relationship Management (CRM), Automotive Sales, Loan Interest Rate, Macroeconomic Factors, Thailand. 56

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 The Impact of Teamwork Perception on Organizational Commitment through the View of Team Characteristic and Process Arissara Makbungwun Bangkok, 10240 Thailand [email protected] Abstract This significant study area of team development has covered in the aspects on workplace commitment. This paper seeks to question and discuss the relevance of employee perception of teamwork capability and organization commitment. In particular, it aims to describe the team factors which indicate team performance evaluated by individual attitudes and draw up the relationship between teamwork perception and organizational commitment. The study constructed main variables which interact with teamwork performance in perception of employees. Those independent variables are 1) team characteristics (goal& roles clarify, individual personality, culture diversity value and team size) and 2) team process (task interdependence, effective training and communication). The study is based on a survey of 201samples of various Thai employees. The finding reveals that team characteristics (team size, goal& roles clarify, agreeableness and culture diversity value) and team task process (effective communication and training) impacts on the perception of employee in team ability. The paper suggests that firm might develop a training programs and communication supports for stimulating the collaboration between member in work teams in culture learning and knowledge exchange in order to gain management efficiency. Keywords: Teamwork, Team Performance, Organizational Commitment 57

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 Factors Influencing the Resistance to Organizational Change Among Employees in Thailand: A Generational Perspective Dares Wannasook Bangkok-10240 Thailand [email protected] Abstract The research aims to explore the influence of employee participation, motivation, trust and communication on employee resistance to organizational change. The study also explores the degree to which the relationships are moderated by the generational differences (baby boomer, generation X and Y). The rapid growth of the new technological advancements and new processs of work is inevitable. Organizational change occurs from both internal and external factors, which causes complicate responses from the organization’s employees as active support or active resistance. The theoretical framework was based on various research that contributed to the understanding of resistance to organizational change and how the generational influence happened. The study employed a quantitative research method and a five point Likert-scale was used to measure the variables employee participation, motivation trust, communication and resistance to change. The sample comprises of 300 employees from various departments in a few logistic organizations in Thailand. The results of the study indicated there were significant influences of these factors on the resistance to change. Keywords: Organizational Change, Generational Differences, Employee Resistance, Participation, Motivation, Trust, Communication. 58

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 Airport of Thailand Employees’ Perception in Human-Organizational and Technological Primary BPR Factors and Their Causal Relationships Towards Airport Operational Performance Shompunutt Na Ayudhya, P. Abstract In this research, the author explores the dimensions of Business Process Re-engineering (or BPR) in the context of airport management at Don Mueang and Suvarnabhumi airports; AOT’s bangkok-based airports. The data collection is done via the select set of questionnaires given to the airport employees (200 PAX) of key departments, within the 2 main concerns under BPR umbrella; A) “BPR Acceptance,” within it resides the set of variables relating to a.1) Human-related factors, a.2) Organization-related factors and a.3) Emotional responses; and B) “BPR Methods & Tools” which consist of b.1) Technological of facilitation and b.2) Perception of Airport Service Quality or ASQ. The research was conducted while there was a realization of BPR which are carried out by the airport IT- based application re-design (database migration from Oracle to SAP) which was aimed to assist the staffs in carrying out their daily tasks, and perception of ASQ in which it concerns the methods and tools; such as airport facilities the employees use to facilitate passengers. This ultimately resulting in higher job performance and assist them in accepting the concept of BPR; and intern boosting the service level for passengers who use the various airport services. 59

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 The Influential factors on customer satisfaction towards Public Healthcare Services in Health Industry: (A Case Study of Patient’s Satisfaction in Public Healthcare Services at Hospitals in Yangon, Myanmar) Mr. Kung Za Hmung @ Win Hlaing Oo MBA Student, Assumption University, Yangon, Myanmar, [email protected] Dr. Seongdok Kim, Ph.D. Graduate School of Business, Assumption University, Thailand, [email protected] Dr. Rawin Vongurai Ph.D. Graduate School of Business, Assumption University, Thailand, [email protected] Abstract The aim of this study is to analyze factors affecting on customer satisfaction toward public health services at hospitals in Yangon, Myanmar. The variables that have been used in this study framework are tangibles, responsiveness, reliability, empathy and assurance from service quality dimension. The questionnaire was conducted as the chosen method to obtain data from 200 respondents in Yangon area only by using non-probability convenience sampling method. The main method used to apply for this study are multiple linear regression was used to analyze the data. The finding suggested that by increasing the customer satisfaction toward public health services at hospitals in Yangon, Public health services at hospitals in Yangon should focus more on empathy, reliability and responsiveness than tangible and assurance. Keywords: customer satisfaction, tangible, reliability, responsiveness, empathy, assurance, public health services at hospitals in Yangon 60

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 Component Analysis of Training English Teacher in Private Institution of Higher Education Napasamon Nanthamatcha Department of Business English, Faculty of Art, North Bangkok University E-mail: [email protected] Abstract The objective of this study is to study and analyze the component of training English teacher including evaluating the component analysis of training English teacher in private institution of higher education. Factor analysis was used as statistic method to find the proper component. The result of component analysis of training English teacher consisted of three components, which were the component regarding learning management containing 10 variables correlation, component regarding curriculum containing 5 variables correlation, and component regarding learning standard containing 5 variables correlation. There components could be applied to develop the training of English teacher further. Keywords: Component Analysis, Training English Teacher, Private Higher Education 61

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 POSTER PRESENTATIONS Date: May 25, 2018 Health Sciences, Business Administration and Management No. Submission Paper Title Author(S) ID Efficacy of Topical Licochalcone A Cream Panumas Na Pattalung Versus Topical Placebo Cream for Facial 1 3110 Seborrheic Dermatitis: A Randomized, Double- Tanomkit blind, comparative Clinical Trial Pawcsuntorna 2 3148 Botulinum Toxin A and Keloid Peeranapak Watanyousiripunya Efficacy and Safety of Non-Invasive 3 3159 Abdominal Tighetining with High-Intensity Thaksaporn Focused Ultrasound (HIFU) in Postnatal Case: Kridsuriya The Clinical Trial Study 4 3162 Clinical Study of Ablative Fractional Carbon Chatchalee Dioxide Laser with Topical Epidermal Growth Patthanapalakornskul Factor for Facial Rejuvenation Comparative Study of Ablative Frictional 5 3129 Carbon Dioxide Laser with or without Nuttapol Nuntasena Autologous Platelet-Riched Plasma 6 3136 The Clinical Efficacy of Topical Platelet-Rich Saravut Plasma with Fractional Radiofrequency Ruangprapavut Microneedle for Attrophic Acne Scar Sumate Kungching 62

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 The Comparison Between Intradermal Injection 7 3152 of Botulinum Toxinand Hyaluronic Acid for Natwadee Nimitkul Skin Tightening: A Split-face Randomized, Double-Blind, Clinical Trial 8 3160 Safety of Efficacy of Continuous Macro Chalida Phoobangkerdphol Focused Ultrasound for Abdominal Subcutaneous Adipose Tissue Reduction 9 3161 The Comparison of Efficacy of Intradermal Kittiphat Rassameejarukit Abobotulinum Toxin A Injection by Different Dillution for Midface Lifting Piyathida Praditbatuga Factors Affecting Consumer’s Purchase 10 049 Intention Towards Mass International Clothing Jidapa Rhusuwankul Brands Santhiti Treetipbut 63

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 Efficacy of Topical Licochalcone A Cream Versus Topical Placebo Cream For Facial Seborrheic Dermatitis A Randomized, Double-Blind, Comparative Clinical Trial Panumas Na pattalung a, Tanomkit Pawcsuntorna,* aSchool of Anti-Aging and Regenerative Medicine, Mae Fah Luang University, Bangkok, Thailand * Corresponding author: [email protected] Abstract Background: Seborrheic dermatitis is a common, chronic inflammatory disorder. Various treatment options are available, including topical corticosteroid and antifungal agents. Antifungal agents such as ketoconazole are often used. Anti-inflammatory properties of licochalcone A have been reported. Recently licochalcone A has been used successfully in patients with infantile seborrheic dermatitis. Objective: To compare the efficacy of licohalcone A cream with placebo cream in the treatment of facial seborrheic dermatitis. Methods: A total of 20 patients (14 males and 6 females; age 20–50 years) with mild to moderate facial seborrheic dermatitis. Patients were randomized to licochalcone A cream (n = 20) and placebo cream (n = 20) applied twice daily to symptomatic regions, each side of face. The primary outcome was assessed by erythema, scaling, infiltration and pruritus, which were evaluated using a four- point scale (0 to 3) at 0, 4, 8 and 12 weeks. Secondary outcome was patient satisfaction and side-effects. Results: All 20 patients completed the study. Statistically significant difference between licochalcone A cream and placebo cream in clinical severity score was detected. The mean score decreased 86.8 % in licochalcone A group and 4.9 % in placebo group. The highest level of satisfaction (70%) was observed in the licochalcone A group. No side-effect was detected in both groups. Conclusion: Topical licochalcone A cream is markedly higher effective than placebo cream. Topical licochalcone A cream represents an excellent alternative therapeutic modality for treating facial seborrheic dermatitis. Keywords: Seborrheic dermatitis,Licochalcone A. 64

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 The Efficiency of Intradermal Botulinum Toxin Injection in The Treatment of Keloid Peeranapak Watanyousiripunya and Tanomkit Pawcsuntorn Bangkok, 10900, Thailand School of Anti-Aging and Regenerative Medicine, Mae Fah Luang University 38/11-13 Asoke place, sukumvit 21, Asoke rd., Wattana, Bangkok, 10110, Thailand E-mail: [email protected] Abstract Introduction: Keloids occurs from abnormal response in any phases of the wound healing process. Until now, the exact pathophysiology of keloids formation is unknown, make it difficult to find effective treatment strategies for patients. A variety of treatments for keloids have been advocated in the past. The result is variable and recurrences remain common. Intralesional botulinum toxin A was found to be effective on keloid color by reduce pigmentation. Because of its case of application and less complication, it has become an interesting alternative treatment for keloid. Objective: To compare the efficacy of intralesional botulinum toxin A injection versus placebo injections for treatment of keloid. Twenty-four Thai subjects with keloid received three slpit-scar monthly treatments, one side with intralesional botulinum toxin A injection, and the other with intralesional placebo injections. Methods and Materials: A total of 24 patients (21 females and 3 males; age 22-48 years) with keloid received three slpit-scar monthly treatments, one side with intralesional botulinum toxin A injections 2.5 unit/cm3, and the other with intralesional placebo injections. The primary outcome was assessed by Melanin value by Maxemeter®MX18, The Vancouver Scar Scale (VSS), Volume, photographs and Patient Global Satisfactory score at 0, 4, 8 and 12 weeks. Secondary outcome was patient satisfaction and side-effects. Results: All 24 patients completed the study. There was statistically significant decreased in melanin index by Mexameter®MX18 and VSS score of keloid between the intralesional botulinum toxin A and the placebo groups at 12 weeks compared with baseline (p<0.001) with significant difference in between both groups. Global satisfactory score was evenly rated by both groups and there was no significant in between both groups. No adverse effect was observed. Conclusion: The efficacy and safety of the intralesional Botulinum toxin A 2.5 Unit/cm3 injection were evident in the current study from the reducing of subjective complaints and the comparable significant improvement of the objective parameters as well as the melanin value of the keloids in comparison with the placebo. Keywords: keloid, botulinum toxin A 65

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 Efficacy And Safety Of Non-Invasive Abodominal Tightening With High Intensity Focused Ultrasound (Hifu) In Postnatal Case: The Clinical Trial Study Thaksaporn Kridsuriya, Sirintip Chaichalotornkul and Tawee Saiwichai Bangkok-10310, Thailand School of Anti-Aging and Regenerative Medicine, Mae-Fah Luang University, Asoke Place, Sukhumvit 21, Bangkok-10110, Thailand E-mail: [email protected] Abstract Background: Skin laxity is an aesthetic problem that occurs between the ages of 35 and 40 years. Problems with skin laxity and quality also start to appear in younger people as a consequence of pregnancy or sudden weight loss. High Intensity Focused Ultrasound or HIFU is now a one of effective non-surgical procedure to treat mild-to-moderate skin laxity. In this study, we sought to determine the clinical efficacy and safety of High Intensity focused ultrasound for abdominal tightening in postnatal woman and follow up at 4, 8 and 12 weeks. Objective: To study effect and safety of High Intensity Focused Ultrasound to treat abdominal skin laxity. Material and Methods: Eleven postnatal participants with mild to moderate abdominal skin laxity were enrolled in this clinical trial study. The participants were treated with HIFU at lower abdominal area compare with control group. Three blinded independent dermatologists assessed results using standardized photographs according to the Global Aesthetic Improvement Scale (GAIS) evaluated paired pre- and post-treatment (week 4, 8 and 12). Skin elasticity was measured before and after treatment (week 4, 8, 12) using a Cutometer (MPA580, Courage and Khazaka®, Cologne, Germany). Participants also completed self-assessments using GAIS. Subjects rated their pain on a numeric rating scale (NRS) immediately, 4 weeks, 8 weeks and 12 weeks after treatment. Results: Skin elasticity measured via a Cutometer was significantly improved immediately after treatment compare with control group (p = 0.006) and also significantly improved after treatment within group compare with baseline at 8 weeks (p =0.044) and 12 weeks (p =0.002). Physicians GAIS showed clinical improvement 4 weeks after treatment (mean ± SD: 2.94 ± 0.25). According to Subjects GAIS also showed clinical improvement immediately after treatment (mean ± SD: 3.27 ± 0.65). Immediately after treatment the mean NRS score was 5.36 ± 2.54, but no pain was reported at weeks 4, 8 and 12 after treatment. No permanent adverse effects were observed during the follow-up period. Conclusion: In case of postnatal abdominal tightening. HIFU appears to be a safe and effective treatment modality to improve skin elasticity for dermal and subdermal tightening. Keywords: High Intensity Focused Ultrasound (HIFU), Skin laxity, Abdominal tightening. 66

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 Clinical Study of Ablative Fractional Carbon Dioxide Laser With Topical Epidermal Growth Factor For Facial Rejuvenation Chatchalee Patthanapalakornskul and Paisal Rummaneethorn Nonthaburi, 11000, Thailand School of Anti-Aging and Regenerative Medicine, Mae-Fah Luang University, Asoke Place, Sukhumvit 21, Bangkok, 10110, Thailand E-mail: [email protected] Abstract Background: Utilizing advanced laser technology, the ablative fractional thermolysis has shown acceptable clinical outcomes with less down time for patients and fewer overall adverse effects, the down time associated with ablative fractional laser treatment still remains a problem. How to reduce down time of fractional CO2 laser, while enhancing its rejuvenation effect, has become one hot topic in dermatological research field. Therefore, the application of ablative fractional CO2 lasers with topical epidermal growth factor are considered synergistic effect for facial rejuvenation. Objective: To study about clinical efficacy, complications and subject’s satisfaction of ablative fractional CO2 laser treatments with topical epidermal growth factor for facial rejuvenation. Methods: Fourteen volunteers who want to do facial rejuvenation were recruited. All subjects received two full-face sessions of fractional CO2 laser treatment every four weeks. Topical epidermal growth factor was applied on full face after laser peel. All subjects had been taken a photograph by VISIA®. Clinical improvement of skin texture was evaluated by two independent physicians at 1 and 2 months after the last treatment. Other parameters measured by cutometer and tewameter had been recorded. Side effects were recorded after each treatment session. Satisfaction scores were surveyed after 2-month post-treatment. Results: Mean of improvement scale from physician were 1.00 (SD = 0.78) at 1-month follow-up, 1.46 (SD = 0.60) at 2-month follow-up. There was significant difference of mean improvement score at 1 and 2 months’ follow-up (p=0.008). From the study, the mean “R2” ratio scores changed from 0.6604 at baseline to 0.7559 at 1month follow-up and 0.7900 at 2month follow-up. There were both statistical significance in ability of returning at 1 month (-0.0955 ± 0.0496; p<0.001) and 2 month follow-ups (-0.1296 ± 0.0532; p<0.001) compare to baseline. The mean TEWL ratio changed from 5.70 at baseline to 5.53 at 1month follow-up and 5.19 at 2month follow-up. Comparison transepidermal water loss between baseline and1 month follow-ups, we found no statistically difference between this period (0.17 ± 0.31; p= 0.053). Whereas there were statistically difference transepidermal water loss between baseline and 2 month follow-ups (0.52 ± 0.34; p<0.001). Most of subjects (85.7%) satisfied the result of treatment. The highest incidence of side effects was immediate erythema occurred in all subjects (100%). None of volunteers indicated serious side effects. Conclusion: The combination of ablative fractional CO2 laser with topical 67

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 epidermal growth factor can be effective treatments for facial rejuvenation. Keywords: Fractional CO2 laser, Topical EGF/Epidermal growth factor, Skin rejuvenation A Comparative Study of Ablative Fractional Carbondioxide Laser with or Without Autologous Platelet-Riched Plasma for Hand Rejuvenation: A Randomized Controlled Trial Nuttapol Nuntasena and Paisal Rummaneethorn Bangkok-10900, Thailand School of Anti-Aging and Regenerative Medicine, Mae Fah Luang University 38/11-13 Asoke place, sukumvit 21, Asoke rd., Wattana, Bangkok, 10110, Thailand E-mail: [email protected] Abstract At present, hand rejuvenation has been popular more. Several kinds of treatment have been applied to treat. Ablative fractional CO2 laser (AFCL) is the one option laser that was reported to be effective and safe for hand rejuvenation. Whereas PRP is increasingly popular in aesthetic field because of composing of growth factor and acceleration of wound healing. Objective is to compare the efficacy and side effect of using AFCL+PRP versus AFCL in improvement of hand rejuvenation. The material and method; 24 Thai women and men volunteers, age between 30-65 years’ old who stay in Bangkok, Thailand were enrolled in this study. The hand of each participant was randomed to treat, one side was treated by AFCL while the another side was treated with AFCL+PRP. All volunteers were treated for 2 times with spacing 4 weeks’ interval and following up 3 times with spacing 4 weeks’ interval. The improvements of smoothness, wrinkle, elasticity, melanin, moisture, oiliness, TEW were measured via the machine namely cutometer MPA 580 and skin visiometer SV 600. Moreover, the volunteer satisfaction score and the side effect were recorded. For statistical analysis, we used repeated measure ANOVA to compare mean of each factor between 2 groups and Bonferroni to compare before-after in the same group. Paired t-test was used to compare percent change between 2 groups. Also, McNemar test was used to compare in satisfaction score between 2 groups. P-value < 0.05 was considered as statistical significant. The result showed that AFCL+PRP group were significantly better than AFCL group in smoothness, wrinkle, elasticity at week4,8 (PSM=0.012*,0.011*;PWr=0.000* ,0.000*;PElas=0.034*,0.000*) .AFCL+PRP group had less side effect of burning sensation ,edema, erythema than AFCL group. Moreover, there weren’t serious side effect in this study. The conclusion showed that AFCL with autologous PRP was more effective than AFCL for hand rejuvenation in term of smoothness, wrinkle and elasticity. Additionally, AFCL+PRP provided less side effect than AFCL. 68

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 Keywords: Ablative fractional CO2 laser; Platelet- riched plasma; Hand rejuvenation The Clinical Efficacy of Topical Platelet-rich Plasma with Fractional Radiofrequency Microneedle for Atrophic Acne Scar Saravut Ruangprapavut, Sumate Kunching and Paisal Rummaneethorn Bangkok, 10110, Thailand School of Anti-Aging and Regenerative Medicine, Mae Fah Luang University 38/11-13 Asoke place, Sukumvit 21, Asoke rd., Wattana, Bangkok, 10110, Thailand E-mail: [email protected] Abstract Background: Acne scarring is a frequent complication of acne vulgaris. Recently, a novel fractional radiofrequency microneedle system has been introduced for the purpose of treating acne scars. Additionally, Platelet-rich plasma has potential benefits in treatment of acne scars. For this research, we evaluated efficacy and safety of the combination technique for acne scars treatment. Objective: To study about efficacy and other effects of the combination treatments on acne scars. Materials and methods: It is experimental study. 19 participants with atrophic acne scars age between 18 – 45 years old were enrolled then treated with fractional radiofrequency microneedle (FRM) and platelet-rich plasma (PRP) at week 0, 4th and 8th then participants were followed up at week 4th and 8th. Clinical outcome which took by VISIA® complexion analysis was evaluated by 2 independent physicians before and after each treatment and also skin elasticity was evaluated by Cutometer® MPA 580. Moreover, Sebum production was evaluated by Sebumeter® SM815. Finally, volunteers’ satisfaction was evaluated by questionnaire after the last follow-up. Adverse reactions were also recorded. Results: 19 participants were enrolled. 1 patient was drop out at the second treatment (4th week), and 18 participants were evaluated. Acne grading between baseline and follow-up both times time were statistically different with p<0.001. Moreover, there were significant difference of improvement score at week 4th and 8th follow-ups (p=0.002). There was statistical significance (p=0.005) had increase elasticity at 8th week follow-ups. For sebum production, there were statistical significance (p=0.024) had decrease sebum production at 8th week follow-ups. At the last time follow-up, participants had most scores for improvement of acne scar as “satisfied” (38.89%). Conclusion: Combination of FRM and PRP treatment can be effective treatments for atrophic acne scars. Cutometer found more elasticity at 2-month follow-up. Sebumeter found less sebum production at 2-month follow-up. Longer follow-ups for next studies should be done for acne scar treatment. 69

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 Keywords: Fractional Radiofrequency Microneedle/Platelet-rich Plasma/Acne Scar The Comparison Between Intradermal Injection of Botulinum Toxin and Hyaluronic Acid for Skin Tightening: A Split-face Randomized, Double-blind, Clinical Trial Natwadee Nimitkul and Phisal Rammaneethorn Bangkok-10900, Thailand School of Anti-Aging and Regenerative Medicine, Mae Fah Luang University 38/11-13 Asoke Place, Sukumvit 21, Asoke Rd., Wattana, Bangkok, 10110, Thailand E-mail: [email protected] Abstract Introduction: Skin changes associated with aging, such as loss of elasticity and sagging, can have a negative psychosocial impact. There are multiple current treatment options that aim at restoring elasticity and tightening the skin such as intradermal injection of botulinum toxin and intradermal injection of hyaluronic acid but there is no comparative study. Objective: This study is about to compare the efficacy between intradermal botulinum toxin and hyaluronic acid injection in facial skin tightening and skin elasticity. Methods and Materials: In this study, each of 11 patients underwent single treatment session with randomly injection of intradermal botulinum toxin on one side of face and hyaluronic acid on another side. Clinical evaluation was assessed by three blind dermatologists to determine the efficacy of facial tightening compared intradermal botulinum toxin injection with intradermal hyaluronic injection and also compared to baseline(control). Biophysical evaluation parameters, elasticity, melanin index and skin hydration were measured before treatment session, immediate after treatment session and at 2, 4 and 8 weeks after the treatment session. Patient satisfaction was assessed, and photographs were taken at each visit. Results: During the course of study, facial skin tightening and skin elasticity was improved on both sides but much better on the side treated with intradermal hyaluronic acid injection. Patient feedback was also extremely positive on the side treated with intradermal hyaluronic acid injection. Conclusion: Both methods can improve skin elasticity but clinical facial tightening on the side treated with intradermal hyaluronic acid injection is much better comparing to intradermal botulinum toxin injection. Keywords: mid-face lifting, botulinum toxin, hyaluronic acid, intradermal injection, facial rejuvenation, 70

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 elasticity, skin hydration. Safety and Efficacy of Continuous Macro Focused Ultrasound For Abdominal Subcutaneous Adipose Tissue Reduction Chalida Phoobangkerdphol and Atchima Suwanchinda Bangkok, 10900, Thailand School of Anti-Aging and Regenerative Medicine, Mae Fah Luang University 38/11-13 Asoke Place, Sukhumvit 21, Asoke Rd., Wattana, Bangkok, 10110, Thailand E-mail: [email protected] Abstract Introduction: HIFU treatment is a non-surgical fat reduction procedure that permanently destroys unwanted subcutaneous abdominal fat. Most of current HIFU products in market use micro focused ultrasound technology. The new macro focused scanning ultrasound “SCIZERTM” can create deeper focal energy zone and bigger spot size. Objective: This study was an experimental study. Researcher attempted to evaluate the efficacy and safety of macro focused scanning ultrasound technology for abdominal SAT reduction. Methods and Materials: 25 participants were received two sequential treatments every 1 month in the abdominal region using 2.0 MHz; 9mm and 2.0 MHz; 13 mm cartridges with 46 x 46mm treatment site zone. Total energy of each site zone was 180 Joule/cm2. Waist circumference and skinfold thickness were recorded after each procedure. Two patients randomly underwent MRI study. Adverse side effect was recorded. Results: Waist circumference was decreased after treatment at all treated sites (P< 0.001). Mean skinfold thickness reduction was also statistically different with P<0.001. Mean participants scored satisfaction subjectively as 4.84 out of 5. Mean pain score during treatment was 6.32 out of 10. 48% of participant had transient mild erythema and 8% had mild skin edema immediately after HIFU procedure. No severe adverse side effect was noted during and after treatment. Conclusion: Macro focused scanning ultrasound is an effective procedure for removing unwanted subcutaneous abdominal fat with mild degree transient side effects. Keywords: Macro focused scanning ultrasound, subcutaneous abdominal fat. 71

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 The Comparison of Efficacy of Intradermal Abobotulinum Toxin A Injection by Different Dilution for Midface Lifting Kittiphat Rassameejarukit and Rassapoom Sumaetheiwit Bangkok, 10900, Thailand School of Anti-Aging and Regenerative Medicine, Mae Fah Luang University 38/11-13 Asoke Place, Sukhumvit 21, Asoke Rd., Wattana, Bangkok, 10110, Thailand E-mail: [email protected] Abstract Introduction: Intradermal botulinum toxin injection is known as one of non-invasive, effective, and safe procedure for midface lifting. However, there is only instruction for preparing the concentration of Abobotulinum toxin from the manufacturer. Later, several studies found that the low concentration/ higher volume increased the effect on the distribution of toxin. According to the effect of dilution, the researcher decided to change in the concentration and volume used to achieve better results. Objective: To compare the efficacy of intradermal abobotulinum toxin injection by different dilution for midface lifting. Methods and Materials: Twenty-two participants with mild facial skin laxity were randomly received intradermal abobotulinum toxin injection in high concentration/ lower volume (50 units in 0.7 ml of NSS) on one-sided face and low concentration/ higher volume (50 unit in 1.4 ml of NSS) on another side. All participants had been taken a photograph by VISIA® and measured skin elasticity by Cutometer®. Result were evaluated by three blinded dermatologists, using Global Aesthetic Improvement Scale (GAIS). Adverse effect was noted during and after treatment. Clinical visits were scheduled at immediate after treatment, day 14, 30 and 60 after treatment. Results: Low concentration/ higher volume injection showed significantly greater mean GAIS of midface lifting at day 14 after treatment (p=0.0428). Skin elasticity showed significantly improvement at day 14 after treatment (p<0.001) but did not show the differences between two dilutions at any time points. Most of the 72

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 participants had moderate level of satisfaction. Asymmetrical smiling was taken place in one case. Conclusion: Intradermal abobotulinum toxin injection of low concentration/ higher volume had the appreciable efficacy and safety profile after single treatment for midface lifting. Therefore, it can be an alternative option for physicians compared to conventional clinical dilution or other procedures. Keywords: Abobotulium toxin / Intradermal injection / Dilution / Midface lifting 73

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 CONFERENCE COMMITTEE The International Conference of Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 1. Board of Directors Advisory Advisory Rev. Bro. Dr. Prathip Martin Komolmas Advisory Rev. Bro. Dr. Bancha Seinghiran Advisory Rev. Bro. Dr. Achin Tengtrakul Director Rev. Bro. Dr. Sirichai Fonseka Associate Director Dr. Kitti Phothikitti Committee Dr. Kittikorn Dowpiset Committee Asst. Prof. Dr. Chaninthorn Committee Dr. Soonthorn Pibulcharoensit Committee Dr. Uree Cheasakul Committee Asst. Prof. Dr. Nanthaphan Chinlumprasert Secretary Associate Professor Dr. Jirapun Daengdej Dr. Witsaroot Pariyaprasert Director Associate Director 2. Conference Advisors Committee Committee Dr. Kitti Phothikitti Committee Dr. Kittikorn Dowpiset Committee Dr. Vorapot Ruckthum Committee Dr. Witsaroot Pariyaprasert Committee Asst. Prof. Dr. Chittipa Ngamkroeckjoti Committee Dr. Apichart Intravisit Committee Dr. Thongdee Kijbooncho Committee Asst. Prof. Dr. Chittipa Ngamkroeckjoti Committee Dr. Seongdok Kim Secretary Dr. Marissa L. Fernando Dr. Rawin Vongurai Director Mr. Rangsan Traibutra Mr. Ehsan Karim Associate Director 3. Editorial Committees Committee Asst. Prof. Dr. Sirion Chaipoopirutana Committee Assumption University of Thailand Dr. Apichart Intravisit Assumption University of Thailand Prof. Dr. Meyer Waarden Lars University Toulouse 1 Capitole, France Prof. Dr. Herbert Paul The University of Applied Sciences in Mainz, Germany 74

International Conference on Entrepreneurship and Sustainability in the Digital Era ICESDE 2018 Assumption University of Thailand May 25, 2018 Dr. Khin Naing Oo Committee Yangon University of Economies, Myanmar Asst. Prof. Dr. Chittipa Ngamkroeckjoti Committee Assumption University of Thailand Committee Committee Asst. Prof. Dr. Kriengsin Prasongsukarn Committee Assumption University of Thailand Committee Dr. Marisa S. L. Fernando Assumption University of Thailand Dr. Aaron Loh Assumption University of Thailand Dr. Rawin Vongurai Assumption University of Thailand The International Conference of Entrepreneurship and Sustainability in the Digital Era (ICESDE) 2018 Reviewers 1. Prof. Dr. Meyer Waarden Lars 2. Asst. Prof. Dr. Sirion Chaipoopirutana 3. Asst. Prof. Dr. Chittipa Ngamkroeckjoti 4. Associate Professor Dr. Jirapun Daengdej 5. Asst. Prof. Dr. Nanthaphan Chinlumprasert 6. Dr. Witsaroot Pariyaprasert 7. Dr. Apichart Intravisit 8. Dr. Marrisa L. Fernando 9. Dr. Aaron Loh 10. Dr. Bhumiphat Gilitwalla 11. Dr. Ioan Voicu 12. Dr. John Barnes 13. Dr. Adarsh Batra 14. Dr. Seongdok Kim 15. Dr. Rawin Vingurai 16. Dr. Raman Kumar 17. Dr. Kittikorn Dowpiset 18. Dr. Lee Hsing Lu 19. Dr. Sirichai Preudhikulpradab 20. Dr. Jacquiline M. Stravros 21. Dr. Nungruetai Kanchantra 22. Dr. Vorapot Ruckthum 75