Department of Anesthesiology, Perioperative and Pain Medicine Annual Report 2020/2021

2021 Annual Report Department of Anesthesiology, Perioperative and Pain Medicine 1

Department of Anesthesiology, Perioperative and Pain Medicine by the numbers 153 41 112 faculty anesthesiologists CRNAs residents 35 480 fellows in ACGME-accredited total employees fellowships 22,317 45,614 annual pain clinic visits annual anesthetics $13,176,290 annual research funding, including $8.5M from NIH/DHHS 2

A Letter from the Chair The Department of Anesthesiology, Perioperative and Pain Medicine is one of the world’s premier academic medical centers, providing clinical anesthesia services to more than 45,000 patients annually undergoing scheduled and emergent surgical procedures across three campuses. We provide pre-operative evaluation and optimization, post-surgical intensive care, postoperative acute pain care, chronic pain care, and palliative care. Our mission is to deliver exceptional patient care, conduct innovative research, and educate transformational leaders in the art, science, and practice of anesthesiology, perioperative and pain medicine. This report highlights some of the extraordinary achievements of the Department and its individual members during the past year as they work to fulfill our mission. Our team stepped forward in countless ways to meet the new and ever-changing demands of the COVID pandemic while providing direct patient care and leadership throughout the organization. Everyone came together to ensure that our patients and colleagues were as safe as possible throughout. From stepping in to care for critically ill patients in COVID ICUs and the operating rooms to finding innovative ways to sanitize masks and increase our supplies of personal protective equipment, everyone found a way to contribute. We have welcomed many new faculty anesthesiologists and Certified Registered Nurse Anesthetists (CRNAs) to the Department during the past year. Among the arrivals, Raquel Bartz, MD, MMCi joined our leadership team as Associate Chair for Critical Care Medicine, and Jeffrey Karp, PhD and his colleagues joined the Department in the Center for Nanomedicine, further expanding our footprint in innovative research into novel applications of material science in medicine. This annual report illustrates the growth and success of the Department in the face of unprecedented challenges and provides a brief overview of who we are and some of the work we do. Our vision is to foster a dynamic workplace culture that attracts exceptional trainee and faculty clinicians, educators and scientists and enables original and lasting innovations that transform health care. I am very proud to be a member of the Brigham Anesthesia Family, where it is abundantly clear that the future of our specialty is indeed bright. James P. Rathmell, MD, MBA Chair, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital Leroy D. Vandam Professor of Anaesthesia, Harvard Medical School 3

Diversity, equity and inclusion In July 2020, Dr. Jim Rathmell, joined a group of faculty and trainees to discuss how our department could best develop a meaningful and durable approach to Diversity, Equity and Inclusion (DEI). From this meeting and with the support of Dr. Rathmell and the BWH Anesthesia Executive Leadership Committee, the Brigham Anesthesia Diversity, Equity and Inclusion Task Force was formed. Anesthesia Diversity, Equity The task force objectives were DEI task force process and Inclusion Task Force to identify DEI evidence based best practices, create opportunities for 1 Dominique Arce, MD, MPH employees to provide feedback Task Force Chair about our approach to DEI and the Review Department approach to DEI current climate and culture, formulate Sub-Committee Organizers recommendations to positively impact 2 diversity, equity and inclusivity in Linda Aglio, MD MS the Department (see DEI Task Force Identify areas for DEI improvement Alexander Arriaga, MD, MD, MPH, ScD Process). Lisa Crossley, MD 3 Brian Donnenfeld, MD The task force recommended that Jimin Kim, MD a leader be named who would create Propose action plans for DEI Morana Lasic, MD a strategic vision for DEI, and lead improvement Sian O’Leary, DNP, CRNA implementation of this vision within the Carmelita Pisano, MD Department. After a comprehensive 4 Maitriyi Shah, MD search, Dominique Arce, MD, MPH who Alissa Sodickson, MD served as Chair of the BWH Anesthesia Investigate methods for Viet Vo, MSN, CRNA DEI Task Force, was named the Director implementation Luai Zakaria, MD of DEI for the. In her new role, which Jose Zeballos, MD began July 1, 2021, Dr. Arce will provide 5 leadership for DEI initiatives across Task Force Members the department’s clinical, research Set short/long term goals and and education domains. She will serve timelines Dr. Brian Bateman, MD, MSc as a member of our department’s Leah Baez, I.m.D. Executive Leadership Committee 6 Sascha Beutler, MD, PhD and be well positioned to enact plans Tara Carey, MD recommended by the task force. She Suggest means for evaluation and Naida Cole, MD will work closely with the faculty, metrics of success Lauren Gibbs, CRNA division chiefs, and education leaders Lindsay Gittens, MD to create an organizational culture that other DEI leaders locally and nationally, Meera Grover, MD promotes diversity, equity and inclusion. 7) fostering pipeline programs Susan Hartman, MS, CRNA with Historically Black Colleges David Hepner, MD, MPH Dr. Arce’s priorities include 1) and Universities and 8) engaging in Susan Klainer, MD increasing recruitment of UiM community outreach to establish trust Mary Morales, MD faculty and trainees, 2) creating among minority communities and Jochen Muehschlegel, MD, MMSc greater opportunities for current UiM introduce the feasibility of careers Ehren Nelson, MD faculty members to participate in in medicine to school age children. Amy O’Brien, MD Departmental/hospital-wide leadership Examination and modification of current Mieke Soens, MD 3) increasing transparency of academic policies and practices, which are in-line Elizabeth Stocksdale, MSN, CRNA advancement, promotions and with recent goals set by the Brigham Jeffrey Swanson, MD leadership opportunities, 4) providing and Women’s Physician Organization Bushra Taha, MD support for faculty development and and Mass General Brigham, will Richard Urman, MD, MBA trainee education on DEI issues, 5) positively impact the advancement Erik Velez, MD creating methods for Departmental of our collective diversity, equity and William White, MS, CRNA communication regarding DEI initiatives, inclusivity. Christina Williams, MD 6) establishing relationships with Stephanie Yacoubian, MD Hannah Zentner, DNP, CRNA Jie Zhou MD, MS, MBA, PhD

Mission Why we exist To deliver exceptional patient care, conduct innovative research, and educate transformational leaders in the art, science, and practice of anesthesiology, perioperative and pain medicine. Vision What we want to be To foster a dynamic workplace culture that attracts exceptional trainee and faculty clinicians, educators and scientists and enables original and lasting innovations that transform health care. 5

Faculty The Department of Anesthesiology, Perioperative and Pain Medicine has a long history of investing in faculty development through formal and informal mentorship, coaching, leadership and research training, research grant funding, and diversity training. Ambulatory/Gynecology Cardiac Anesthesia Critical Care Medicine Anesthesia Douglas Shook, MD Raquel Bartz, MD, MMCi Brian Donnenfeld MD Division Chief Division Chief Division Chief Assistant Professor of Anaesthesia Associate Professor of Anaesthesia Instructor in Anaesthesia Cathleen McKeating, MD Lauren Cornella, MD Joshua Finkel, MD Instructor in Anaesthesia Instructor in Anaesthesia Instructor in Anaesthesia Beverly Philip, MD Professor of Anaesthesia John Fox, MD Arthur Formanek, MD Assistant Professor of Anaesthesia Instructor in Anaesthesia Kara Joseph, MD Gyorgy Frendl, MD Member of Anaesthesia Faculty Associate Professor of Anaesthesia Sergey Karamnov, MD Caroline Gross, MD Assistant Professor of Anaesthesia Instructor in Anaesthesia Elizabeth Magdycz, MD Matthew Grunert, MD Instructor in Anaesthesia Instructor in Anaesthesia Jennifer McSweeney, MD Suzanne Klainer, MD Instructor in Anaesthesia Instructor in Anaesthesia Jochen Muehlschlegel, MD, MMSc Daniela Lazea, MD Associate Professor of Anaesthesia Instructor in Anaesthesia Luigino Nascimben, MD, PhD Louisa Palmer, MD, MBBS Assistant Professor of Anaesthesia Instructor in Anaesthesia Charles Nyman, MBBCh Krishna Parekh, MD Instructor in Anaesthesia Instructor in Anaesthesia Jonah Patel Sujatha Pentakota, MD, MBBS Member of Anaesthesia Faculty Instructor in Anaesthesia Gabriela Querejeta Roca, MD Nicholas Sadovnikoff, MD Instructor in Anaesthesia Assistant Professor of Anaesthesia Stanton Shernan, MD Matthias Stopfkuchen-Evans, MD Professor of Anaesthesia Assistant Professor of Anaesthesia Jeffrey Swanson, MD Joshua Vacanti, MD Instructor in Anaesthesia Assistant Professor of Anaesthesia Nelson Thaemert, MD Assistant Professor of Anaesthesia

Obstetric Anesthesia General Anesthesia Neuroanesthesia Michaela Farber, MD, MS Division Chief Zhiling Xiong, MD, PhD Linda Aglio, MD, MS Assistant Professor of Anaesthesia Division Chief Division Chief Assistant Professor of Anaesthesia Associate Professor of Anaesthesia Dominique Arce, MD, MPH Instructor in Anaesthesia Sibinka Bajic, MD, PhD Gregory Crosby, MD Assistant Professor of Anaesthesia Professor of Anaesthesia William Camann, MD Associate Professor of Anaesthesia Sascha Beutler, MD, PhD Lisa Crossley, MD Assistant Professor of Anaesthesia Assistant Professor of Anaesthesia Jean Carabuena, MD Assistant Professor of Anaesthesia Felicity Billings, MD Grace Kim, MD Instructor in Anaesthesia Assistant Professor of Anaesthesia Arthur Chyan, DO Member of Anaesthesia Faculty Tara Carey, MD Dennis McNicholl, DO Instructor in Anaesthesia Instructor in Anaesthesia Naida Cole, MD Instructor of Anaesthesia Martha Cordoba-Amorocho, MD Instructor in Anaesthesia David Combs, MD, PhD Instructor in Anaesthesia Simon Gelman, MD, PhD Vandam/Covino Distinguished Professor Kyle Jespersen, MD of Anaesthesia Instructor in Anaesthesia Meera Grover, MD Jimin Kim, MD Instructor in Anaesthesia Instructor in Anaesthesia Mona Hedayat, MD Chih King, MD, PhD Instructor in Anaesthesia Instructor in Anaesthesia Laura Muehl, MD Vesela Kovacheva, MD, PhD Instructor in Anaesthesia Assistant Professor of Anaesthesia Carmelita Pisano, MD Ayumi Maeda, MD Instructor in Anaesthesia Member of Anaesthesia Faculty James P. Rathmell, MD, MBA Chaim Nelson, MD Leroy D. Vandam Professor of Anaesthesia Member of Anaesthesia faculty Dongdong Yao, MD, PhD Mihaela Podovei, MD Assistant Professor of Anaesthesia Instructor in Anaesthesia Sharon Reale, MD Instructor in Anaesthesia Sarah Seifert, MD Instructor in Anaesthesia Mieke Soens, MD Instructor in Anaesthesia Bushra Taha, MD Instructor in Anaesthesia Lawrence Tsen, MD Associate Professor of Anaesthesia Jie Zhou, MD, MS, MBA, PhD Assistant Professor of Anaesthesia

Orthopedic and Regional Out of OR Anesthesia Pain Medicine Anesthesia Christopher Gilligan, MD, MBA Kamen Vlassakov, MD Evan Blaney, MD Division Chief* Division Chief Division Chief Assistant Professor of Anaesthesia Assistant Professor of Anaesthesia Instructor in Anaesthesia Pradeep Dinakar, MD Carolyn Buckley, MD Jill Lanahan, MD Assistant Professor of Anaesthesia Instructor in Anaesthesia Division Chief Instructor in Anaesthesia Robert Edwards, PhD Yun-Yun Kathy Chen, MD Associate Professor of Anaesthesia Instructor in Anaesthesia Sukumar Desai, MD Assistant Professor of Anaesthesia Robert Jamison, MD, PhD Stewart Chritton, MD, PhD Professor of Anaesthesia Assistant Professor of Anaesthesia Nada Hart, MD Instructor in Anaesthesia David Janfaza, MD Daniel Fischer, MD Assistant Professor of Anaesthesia Instructor in Anaesthesia Eileen Lynch, MD Assistant Professor of Anaesthesia Alexander Kim, MD Devon Flaherty, MD, MPH Instructor in Anaesthesia Instructor in Anaesthesia Marc Pimentel, MD, MPH Assistant Professor of Anaesthesia Brenda Lee, MD Philipp Lirk, MD, MSc, PhD Instructor in Anaesthesia Associate Professor of Anaesthesia David Preiss, MD, MS, PhD Assistant Professor of Anaesthesia Edward Michna, MD Anne Schools, MD Assistant Professor of Anaesthesia Assistant Professor of Anaesthesia Pankaj Sarin, BS, MD, MS Instructor in Anaesthesia Ariel Morales, MD Kristin Schreiber, MD, PhD Member of Anaesthesia Faculty Associate Professor of Anaesthesia David Selig, MS, MD Instructor in Anaesthesia Sanjeet Narang, MD Erick Velez, MD Assistant Professor of Anaesthesia Instructor in Anaesthesia Srdjan Nedeljkovic, MD Associate Professor of Anaesthesia Ehren Nelson, MD Instructor in Anaesthesia Arti Ori, MD Member of Anaesthesia Faculty Stephanie Regenhardt, MD, PhD Instructor in Emergency Medicine Elizabeth Rickerson, MD Assistant Professor of Anaesthesia Edgar Ross, MD Associate Professor of Anaesthesia Pritesh Topiwala, MD Instructor in Anaesthesia Jason Yong, MD, MBA Interim Division Chief* Assistant Professor of Anaesthesia *Dr. Yong stepped in to serve as Interim Division Chief in late 2021, when Dr. Gilligan assumed a new role as Associate Chief Medical Officer for Perioperative and Procedural Services

Postoperative Pain Service Vascular Anesthesia Foxborough Jose Zeballos, MD Felicity Billings, MD William Dylewsky, MD Division Chief Instructor in Anaesthesia Division Chief Instructor in Anaesthesia Matthew Grunert, MD Instructor in Anaesthesia Galina Davidyuk, MD Instructor in Anaesthesia Regina Torelli, MD Instructor in Anaesthesia Louisa Palmer, MD, MBBS Instructor in Anaesthesia Archana O’Neill, MD Instructor in Anaesthesia Instructor in Anaesthesia Jeffrey Swanson, MD 9 Christine Sang, MD, MPH Instructor in Anaesthesia Associate Professor of Anaesthesia Dirk Varelmann, MD Assistant Professor of Anaesthesia Thoracic Anesthesia Preoperative Evaluation Center Philip Hartigan, MD Division Chief David Hepner, MD, MPH Assistant Professor of Anaesthesia Division Chief Matthew Allen, MD Associate Professor of Anaesthesia Instructor in Anaesthesia Alexander Arriaga, MD, MPH, ScD Ju-Mei Ng, MD Assistant Professor of Anaesthesia Assistant Professor of Anaesthesia Angela Bader, MD Alissa Sodickson, MD Professor of Anaesthesia Instructor in Anaesthesia Morana Lasic, MD Stephanie Yacoubian, MD Assistant Professor of Anaesthesia Instructor in Anaesthesia Richard Urman, MD, MBA Associate Professor of Anaesthesia Urological and Renal Transplantation Anesthesia Brigham and Women’s Faulkner Hospital Matthias Stopfkuchen-Evans, MD Division Chief David Shaff, MD Assistant Professor of Anaesthesia Chief of Anesthesia, Brigham and Women’s Faulkner Hospital Instructor in Anaesthesia

Research Faculty Sergey Karamnov, MD Stanton Shernan, MD Assistant Professor of Anaesthesia Professor of Anaesthesia Linda Aglio, MD, MS Jinjun Shi, MD Associate Professor of Anaesthesia Jeffrey Karp, PhD Associate Professor of Anaesthesia Professor of Anaesthesia Dominique Arce, MD, MPH Mieke Soens, MD Instructor in Anaesthesia Igor Kissin, MD Instructor in Anaesthesia Professor of Anaesthesia Alexander Arriaga, MD, MPH, ScD Matthew Spite, PhD Assistant Professor of Anaesthesia Vesela Kovacheva, MD, PhD Associate Professor of Anaesthesia Assistant Professor of Anaesthesia Angela Bader, MD Gary Strichartz, PhD Professor of Anaesthesia Lazaridou, Asimina, PhD Professor of Anaesthesia (Pharmacology) Instructor in Anaesthesia Raquel Bartz, MD, MMCi Jeffrey Swanson, MD Associate Professor of Anaesthesia Yuhan Lee, MD Instructor in Anaesthesia Instructor in Anaesthesia Brian Bateman, MD, MSc Wei Tao, MD Associate Professor of Anaesthesia Philipp Lirk, MD, MSc, PhD Instructor in Anaesthesia Associate Professor of Anaesthesia Nan Chiang, MD Lawrence Tsen, MD Principal Associate in Anaesthesia Jochen Muehlschlegel, MD, MMSc Associate Professor of Anaesthesia Associate Professor of Anaesthesia Naida Cole, MD Richard Urman, MD, MBA Instructor of Anaesthesia Sanjeet Narang, MD Associate Professor of Anaesthesia Assistant Professor of Anaesthesia Christopher Connor, MD, PhD Dirk Varelmann, MD Assistant Professor of Anaesthesia Luigino Nascimben, MD, PhD Assistant Professor of Anaesthesia Assistant Professor of Anaesthesia Gregory Crosby, MD Kamen Vlassakov, MD Professor of Anaesthesia Srdjan Nedeljkovic, MD Assistant Professor of Anaesthesia Associate Professor of Anaesthesia Deborah Culley, MD Jason Yong, MD, MBA Associate Professor of Anaesthesia Sungwhan Oh, MD Assistant Professor of Anaesthesia Instructor in Anaesthesia Sukumar Desai, MD Jose Zeballos, MD Assistant Professor of Anaesthesia Louisa Palmer, MD, MBBS Instructor in Anaesthesia Instructor in Anaesthesia Robert Edwards, PhD Jie Zhou, MD, MS, MBA, PhD Associate Professor of Anaesthesia Claudio Perez, PhD Assistant Professor of Anaesthesia Assistant Professor of Anaesthesia Michaela Farber, MD, MS Promotions from Assistant Professor of Anaesthesia Beverly Philip, MD June 2020 – December 2021 Professor of Anaesthesia Omid Farokhzad, MD MS Sibinka Bajic, MD, PhD Senior Lecturer, Part-time Marc Pimentel, MD, MPH Assistant Professor (Longer Service) Assistant Professor of Anaesthesia Gyorgy Frendl, MD, PhD Christopher Connor, MD, PhD Associate Professor of Anaesthesia James Rathmell, MD, MBA Associate Professor of Anaesthesia Professor of Anaesthesia (Clinical Expertise and Innovation) Christopher Gilligan, MD, MBA Assistant Professor of Anaesthesia Edgar Ross, MD Galina Davidyuk, MD, PhD Associate Professor of Anaesthesia Assistant Professor of Anaesthesia David Hepner, MD, MPH (Longer Service) Associate Professor of Anaesthesia Christine Sang, MD, MPH Associate Professor of Anaesthesia Nitin Joshi, PhD Robert Jamison, MD, PhD Assistant Professor of Anaesthesia Professor of Anaesthesia Kristin Schreiber, MD, PhD (Investigation) Associate Professor of Anaesthesia David Janfaza, MD Sergey Karamnov, MD Assistant Professor of Anaesthesia Charles Serhan, PhD, DSc. Assistant Professor of Anaesthesia Simon Gelman Professor of Anaesthesia (Clinical Expertise and Innovation) Nitin Joshi, PhD Instructor in Anaesthesia 10

Yuhan Lee, PhD Assistant Professor (Investigation) Sungwhan Oh, PhD Assistant Professor (Investigation) Sharon Reale, MD Assistant Professor of Anaesthesia (Clinical Expertise and Innovation) Elizabeth Rickerson, MD Assistant Professor (Clinical Expertise and Innovation) Kristin Schreiber, MD, PhD Associate Professor (Investigation) Matthias Stopfkuchen-Evans, MD Assistant Professor of Anaesthesia (Clinical Expertise and Innovation) Wei Tao, PhD Assistant Professor of Anaesthesia (Investigation) Kamen Vlassakov, MD Associate Professor (Clinical Expertise and Innovation) Dongdong Yao, MD, PhD Assistant Professor (Longer Service) Appointments from June 2020 – September 2021 Dominique Arce, MD, MPH was Sharon Reale, MD was appointed Obstetric New Faculty appointed Director of Diversity Equity and Anesthesia Fellowship Program Director Inclusion Matthew Allen, MD Kristin Schreiber, MD, PhD was appointed Raquel Bartz, MD, MMCi Raquel Bartz, MD, MMCi was appointed Associate Vice Chair for Research Carolyn Buckley, MD Associate Chair of Critical Care Medicine Yun-Yun Kathy Chen, MD Alissa Sodickson, MD Was appointed Arthur Chyan, DO Sascha Beutler, MD, PhD was appointed Associate Director of the Thoracic Surgery David Combs, MD, PhD Residency Program Director ICU Daniel Fischer, MD Donna Griffith, MD Tara Carey, MD was appointed Associate Jeffrey Swanson, MD was appointed Meera Grover, MD Vice Chair for Faculty Development, Director of Perioperative Ultrasound Mona Hedayat, MD Engagement and Wellbeing Annette Ilg, MD Kara Joseph, MD Michaela Farber, MD, MS was appointed Alexander Kim, MD Division Chief of Obstetric Anesthesiology Chih King, MD, PhD Elizabeth Landry, MD David Hepner, MD, MPH was appointed Brenda Lee, MD Vice Chair for Perioperative Medicine Mckenna Longacre, MD, MM Daniela Lazea, MD was appointed Ayumi Maeda, MD Co-Director of the Surgical Intensive Care Elizabeth Magdycz, MD Unit Cathleen McKeating, MD Ariel Morales, MD Louisa Palmer, MD, MBBS was appointed Laura Muehl, MD Director of Critical Care Ultrasound Uzoaru Oguguo, MD Arti Ori, MD Carmen Pisano, MD was appointed Jonah Patel, MD Associate Vice Chair for Clinical Affairs 11

Education Brigham and Women’s Anesthesiology Residency Training Program provides superior clinical training, unparalleled research opportunities, and the highest quality medical care. Our long-standing mission is to train, mentor and develop future leaders in Anesthesiology as physicians and researchers. We seek to nurture all the talents of our residents by fostering a collegial, supportive and inclusive atmosphere. 112 Residents 2020/2021 Megan Hunt, MD Johns Hopkins University School of Medicine anesthesiology residents PGY1s Julian Landaw, MD, PhD 35 Janet Adeola, MD, MS University of California, Los Angeles David Rutgers New Jersey Medical School Geffen School of Medicine fellows Qanetha Ahmed, MD Christopher Mukasa, MD 1 New York University Grossman School of Columbia University Vagelos College of Medicine Physicians and Surgeons ACGME-accredited anesthesiology residency programs Karyn Barrett, MD Timothy O’Malley, MD Drexel University College of Medicine University of Massachusetts Medical School ACGME-accredited anesthesiology fellowships Cameron Bosinski, MD, MS Akash Patel, MD State University of New York Upstate Medical University of Illinois at Chicago College of 3 University Medicine non-ACGME-accredited Katherine Chan, MD Joeli Roth, MD anesthesiology fellowships Harvard Medical School University of Miami Leonard M. Miller School of Medicine Rosalyn Chen, MD Boston University School of Medicine Abel Samanez, MD Donald and Barbara Zucker School of Sherwin Davoud, MD Medicine at Hofstra/Northwell Medical College of Georgia at Augusta University Matthew Smith, MD McGovern Medical School at the University of Texas Health Science Center

Melanie Winters, MD Sarah Osmulski, MD Michael Fiore, MD, Pharm D. New York Medical College Harvard Medical School Chicago Medical School, Rosalind Franklin University of Medicine and Science Ahmed Yousef, MD Gavin Ovsak. MD, MBA University of Miami Leonard M. Miller School Harvard Medical School Gregory Galanti, MD of Medicine Boston University School of Medicine John Ra, MD Andres Zorrilla-Vaca, MD Sidney Kimmel Medical College at Sheila Gokul, MD, MS Universidad del Valle Escuela de Medicina Thomas Jefferson University University of Texas Southwestern Medical Center at Dallas CA1s Christopher Richey, MD Harvard Medical School Dustin Griesemer, MD, PhD Sarah Boden, MD, MS, D. Pharm Harvard Medical School University of Kentucky College of Medicine Olivia Rowse, MD Boston University School of Medicine Irene Kitromelides, MD Ansel Brasseur, MD, MFA Wayne State University School of Medicine Renaissance School of Medicine at Stony Matthew Russell, MD Brooke University Medical College of Wisconsin MaryJo Kramer, MD Georgetown University School of Medicine Richard Bremer, MD Elizabeth Schueth, MD, MPH Wayne State University School of Medicine Indiana University School of Medicine Jennifer Kutt, MD New York Medical College Travis Brown, MD, MS Jocelyn Streid, MD, MPP The Warren Alpert Medical School of Brown Harvard Medical School Patricia LaMontagne, MD University Tufts University School of Medicine Joy Tan, MD Eric Chen, MD, MBA Baylor College of Medicine Ryan Louer, MD Yale School of Medicine Indiana University School of Medicine Daniel Yo, MD Lauren Chibucos, MD McGovern Medical School at The University Petra Majdak, MD, PhD, MS University of Michigan Medical School of Texas Health Science Center University of Illinois College of Medicine Stratton Dangerfield, MD Alexander Yue, MD Taylor Maney, MD George Washington University School of Albany Medical College New York Medical College Medicine and Health Sciences CA2s Maria Moustaqim-Barrette, MD, CM Kate Frost, MD McGill University Faculty of Medicine Vanderbilt University School of Medicine Justin Baker, MD Drexel University College of Medicine Thomas Nguyen, MD Lauren Gilbert, MD, MPH University of California San Francisco New York University School of Medicine Michelle Baker, MD School of Medicine State University of New York Upstate Nirmal Gosalia, MD Medical University Adlai Pappy, MD, MBA University of Illinois at Chicago College of Emory University School of Medicine Medicine William Buchanan, MD University of Mississippi School of Medicine Sylvie Polsky, MD, MS Julia Heunis, MD Wayne State University School of Medicine University of California, San Francisco Christopher Cheung, MD School of Medicine University of California San Francisco School Chetna Prasad, MD, MBA of Medicine Albany Medical College Florence IP, MBBS University of College London Medical School Scott Chung, MD Ryan Sica, MD Perelman School of Medicine at University of University of Virginia School of Medicine Thomas Kimball, MD, MS Pennsylvania New York Medical College Brian Sou, MD Serena Dasani, MD, MBA New York University School of Medicine Shayna Levine, MD, MS Perelman School of Medicine at the Rosalind Franklin University North Chicago University of Pennsylvania John Warwick, MD Warren Alpert Medical School of Brown Andrew Nellestein, MD, MS Grace Donzelli, MD University Georgetown University School of Medicine University of California San Francisco School of Medicine Tiffany Yeh, MD, MS Kevin Osgood, MD Perelman School of Medicine at Tufts University School of Medicine University of Pennsylvania 13

Ian Zheng, MD Stuart Sacks, MD Aiden Feng, MD, MBA University of Miami Leonard M. Miller David Geffen School of Medicine at Staff Anesthesiologist at Pennsylvania School of Medicine University of California Los Angeles Hospital CA3s Erica Seligson, MD Anna Formanek, MD Tufts University School of Medicine Kenny Chan, MD, PhD Katherine Greco, MD University of Miami Miller School of Medicine Zachary Singer, MD Adult Cardiothoracic Anesthesia Fellowship Perelman School of Medicine at Brigham and Women’s Hospital Amar Desai, MD University Massachusetts Medical School Tu Anh Tran, MD Jack Hale, MD Medical College of Georgia Obstetric Anesthesia Fellowship at Brigham Stephen Ellwood, MD and Women’s Hospital Rutgers New Jersey Medical School Natalie Tukan, MD Boston University School of Medicine Mona Hedayat, MD Madison Goldberger, MD Cardiothoracic Anesthesia Fellowship at Sackler School of Medicine Amy Wagenaar, MD Beth Israel Deaconess Medical Center University of Miami Miller School of Medicine Ian Grant, MD Julia Hickey, MD, CM University of Vermont College of Medicine Christina Williams, MD Stanford School of Medicine Stanley Jablonski, MD Elizabeth Hiltz, MD Regional Anesthesia and Acute Pain University of Alabama School of Medicine Jennifer Xiong, MD Medicine Fellowship at Brigham and Medical College of Georgia Women’s Hospital Joseph Homsi, MD University of Massachusetts Medical School Linnea Xuereb, MD Daniel Kang, MD Wayne State University School of Medicine Pediatric Anesthesia Fellowship at Children’s Megan Jablonski, MD Hospital of Los Angeles Medical College of Wisconsin Daniel Yong, MD Wayne State University School of Medicine Daniel Kellner, MD Sarvesh Kaushik, MD University of South Dakota Luai Zakaria, MD Ken Lee, MD University of Chicago Pritzker School of Pain Medicine Fellowship at Brigham and Asha Clarke, MD Medicine Women’s Hospital Geisel School of Medicine at Dartmouth Research Trainees Zachary Lee, MD Kunal Mandavawala, MD Tufts University School of Medicine Cameron Bosinski, MD, MS McKenna Longacre, MD, MM Pediatric Anesthesia Fellowship at Boston Mary Morales, MD Andres Zorrilla-Vaca, MD Children’s Hospital Harvard Medical School Thomas Nguyen, MD Laura Muehl, MD Gwen Owens, MD, PhD Staff Anesthesiologist at Brigham and University of California Los Angeles School 2021 Graduate Residents Women’s Hospital of Medicine Samantha Abel, MD, MS Amy O’Brien, MD Brian Park, MD Obstetric Anesthesia Fellowship at Brigham Pediatric Anesthesia Fellowship at Boston Drexel University College of Medicine and Women’s Hospital Children’s Hospital Stephanie Peters, MD Kaeleen Boden, MD Laura Phelan, MD University of Kansas School of Medicine Regional Anesthesia and Acute Pain Adult Cardiothoracic Anesthesia Fellowship Medicine Fellowship at Brigham and at Brigham and Women’s Hospital Stephen Raithel, MD Women’s Hospital Case Western Reserve School of Medicine Anna Reichardt, MD, PhD Anna Ray, MD Stacey Burns, MD, MBA University of Miami Miller School of Medicine Pain Medicine Fellowship at Brigham and Sara Royston, MD, PhD Women’s Hospital Pain Medicine Fellowship at Brigham and Alexandra Rooney, MD Women’s Hospital Georgetown University School of Medicine Bryan Davis, MD, MAS Pain Medicine Fellowship at Brigham and Neil Shaw, MD Sahar Rosenblum, MD Women’s Hospital Regional Anesthesia and Acute Pain University of California Los Angeles School Medicine Fellowship at Cedars Sinai in Los of Medicine Abram Feldman, MD Angeles Critical Care Medicine Fellowship at Brigham and Women’s Hospital 14

“The past 18 months have been challenging for everyone. The members of this department have persevered through constant change. Department members at all levels have worked together to continue to support our clinical, academic and research missions, despite facing many challenges day in and day out. I think that says a lot about our people and what makes this department great.” Rich Cornell, Executive Administrator Andrew Short, MD Caitlin Burke, MD Ayumi Maeda, MD Regional Anesthesia and Acute Pain Brigham and Women’s Hospital Medicine Fellowship at Brigham and David Buric, MD Women’s Hospital Mayo Clinic in Florida Elizabeth Magdycz, MD Brigham and Women’s Hospital Alexander Stone, MD Jeffrey Carness, MD Tennison Malcolm, MD Ganesh Thippeswamy, MD Yun-Yun Kathy Chen, MD Staff Anesthesiologist at South Shore Brigham and Women’s Hospital David Moore, MD Hospital Staff Anesthesiologist in Atlanta, Georgia Arthur Chyan, DO An Tran, MD Brigham and Women’s Hospital Bryan Nevil, MD Pediatric Anesthesia Fellowship at Stanford Johanna Cobb, MD University Stephanie Regenhardt, MD, PhD Chen Chen Costelloe, MD Beth Israel Deaconess Medical Center Justin Tuwatananurak, MD Private Practice in Washington D.C. Adult Cardiothoracic Anesthesia Fellowship Saniya Sami, MD at Brigham and Women’s Hospital Daniel Fischer, MD Brigham and Women’s Hospital Avijit Sharma, MD Lindsay Wahl, MD Critical Care Medicine Fellowship at Wenxi Gao, MD Andreas Schuler, MD Northwestern South Shore Hospital Michael Williams, MD Frances Wallace, MD Prabhdeep Hehar, DO Staff Anesthesiologist at Winchester Jakob Wollborn, MD Hospital Jessica Ibanez, MD Research Fellowship at Brigham and Women’s Hospital Salim Zerriny, MD Divya Janardhanan, MD Pediatric Anesthesia Fellowship at Boston Jennifer Yu, MD Children’s Hospital Kara Joseph, MD Massachusetts General Brigham Salem Northwestern University Feinberg School of Hospital Yuanting Zha, MD, MPH Medicine Pediatric Anesthesia Fellowship at Seattle Current Fellows Children’s Hospital Alexander Kim, MD Pain Faculty at Brigham and Women’s Adult Cardiothoracic Fellowship 2021 Graduated Fellows Hospital Chinyere Archie, MBBS Kavin Bains, MD Faina Kotova, MD University of the West Indies Faculty of Brigham and Women’s Hospital Medical Sciences, Jamaica Shafik Boyaji, MD Staff Anesthesiologist in Arizona Sindhu Krishnan, MD Benjamin French, MD, MSc Stephanie Bradley, MD, MPH Cedars - Sinai Medical Center Columbia University College of Physicians University of Texas Health Science Center and Surgeons Houston Warren Mackie-Jenkins, MD Staff Anesthesiologist in Virginia 15

Katherine Greco, MD Perelman School of Medicine at University of Pennsylvania Laura Phelan, MD Albany Medical College Justin Tuwatananurak, MD Virginia Commonwealth University School of Medicine Richard Yeom, MD Rutgers Robert Wood Johnson Medical School Katherine Greco, MD Perelman School of Medicine at University of Pennsylvania Laura Phelan, MD Albany Medical College Chinyere Archie, MBBS University of the West Indies Faculty of Medical Sciences, Jamaica Benjamin French, MD, MSc Columbia University College of Physicians and Surgeons Richard Yeom, MD Rutgers Robert Wood Johnson Medical School Justin Tuwatananurak, MD Virginia Commonwealth University School of Medicine Critical Care Medicine Fellowship Jacob Cole, MD, MBA F. Edward Herbert School of Medicine, Uniformed Services University of the Health Science Khanant Desai, MD University of Massachusetts Medical School Roxanne Favis, DO Rocky Vista University College of Osteopathic Medicine Abram Feldman, MD Northwestern University Feinberg School of Medicine Hinna Malik, MD St. Matthew’s University School of Medicine Adeola Omojola, MD University of California San Diego School of Medicine 16

Lyubov Tsytsikova, MD Pain Medicine Fellowship Johnathan Tran, MD Tufts University School of Medicine University of California San Diego School Stacey Burns, MD, MBA of Medicine James Urness, MD Albany Medical College Medical College of Wisconsin Erika Yih, MD Bryan Davis, MD, MAS University of Pittsburgh School of Medicine Leslie Vargas, MD University of California San Diego School Universidad Central de Venezuela Escuela de of Medicine Regional Fellowship Medicina Jose Maria Vargas David Garas, MD, MBA Kaeleen Boden, MD Obstetric Fellowship Sidney Kimmel Medical College at Thomas Case Western Reserve University School Jefferson University of Medicine Samantha Abel, MD, MS University of Miami Miller School of Medicine David Hao, MD Stanley Jablonski, MD Rutgers Robert Wood Johnson Medical Medical College of Wisconsin Monica Gran, MD, MBS School Perelman School of Medicine at University of Andrew Shorten, MD Pennsylvania Rohan Jotwani, MD, MBA University of Cincinnati College of Medicine Tufts University School of Medicine Kate Hackett, MD Thoracic Fellowship Ohio State University College of Medicine Ken Lee, MD, MSc and Public Health Chicago Medical School, Rosalind Franklin Sau Yee Chow, MBBS, MMed University of Medicine and Science Yong Loo Lin School of Medicine, National Jack Hale, MD University of Singapore University of Rochester School of Medicine Jason Ross, MBBS and Dentistry University of Queensland School of Medicine Research Fellowship Heidi Lightfoot, MBBS Sara Royston, MS, MD, PhD Jakob Wollborn, MD St. George’s University of London University of Illinois College of Medicine Julius-Maximilians-Universität Würzburg Medizinische Fakultät Michelle Yanik, MD Brody School of Medicine at East Carolina University New Program Director: Care Medicine, and Perioperative commitment to the residency program Echocardiography. further and was promoted to Associate Dr. Sascha Beutler, MD, PhD Program Director. Throughout her career, Dr. Beutler Dr. Beutler earned her MD /PhD at has had a keen interest in medical Dr. Beutler is committed to promoting the Medizinische Hochschule Hannover education. As a fellow at MGH, she the field of anesthesia, and the role of (MHH) in Germany. Afterwards, she coordinated the critical care curriculum anesthesiologists within the healthcare began the trauma surgery training for residents and fellows. Before joining system and in the public domain. During program at the MHH and obtained the the VA Boston Healthcare System, Dr. residency training Dr. Beutler served Board Certification “Added Qualification Beutler created the framework for a as a resident delegate to the American Rescue Medicine.” After an internship senior MGH anesthesiology resident Society of Anesthesiologists (ASA). She in Internal Medicine and a residency rotation to the VA. In 2005, Dr. Beutler has been an active member of the ASA in Anesthesiology at the Brigham and became the Education Director at Committee of Critical Care Medicine Women’s Hospital (BWH), Dr. Beutler the Department of Anesthesiology and currently has served on the ASA completed a fellowship in Critical Care at the VA. In 2009, she became the Committee Problem Based Learning Medicine at the Massachusetts General off-site Program Director for the newly Discussions, the ASA Committee on Hospital (MGH) and obtained board established categorical internship at Residents and Medical Students, and certification in Anesthesiology, Critical the Brigham. In the following year, she the ASA Education Track Subcommittee became an Assistant Program Director on Perioperative Medicine. Dr. Beutler in our department and reprised her also serves as a senior oral board role as a clinician educator at BWH. In examiner for the American Board of February 2013, Dr. Beutler expanded her Anesthesiologists (ABA). 17

CRNAs Brigham and Women’s Hospital is an international powerhouse in biomedical research dedicated to pioneering discoveries that will translate into new prediction methods, treatments, and cures for the world’s most devastating and complex diseases. Our Certified Registered Nurse provide an inclusive and supportive Current CRNAs Anesthetists (CRNAs) are responsible environment for clinical training. for the preoperative, intraoperative, Lauren Anderson, MS, CRNA and immediate post-operative care SRNA case requirements Amy Arnett, MS, CRNA - locum of patients requiring anesthesia for fulfilled at BWH Olivia Beane, MSN, CRNA - locum surgical, medical, therapeutic or Lindsay Beaudry, DNAP, CRNA diagnostic procedures. With over 20 • Advanced airway Ashley Bobrek, MS, CRNA CRNAs in the anesthesia department, • Ambulatory Kristina DiCamillo, MS, CRNA - per diem their services are rendered in the • Cardiac Karen Driscoll, MS, CRNA main operating rooms, Labor and • ENT Cheryl Goldberg, MSN, CRNA - locum Delivery, and designated out-of- • General Nicole Graham, MS, CRNA - per diem FXB OR locations such as radiology, • Invasive line Susan Hartman, MS, CRNA cardiac catheterization, angiography, • Neuro Amanda Kelly, MS, CRNA endoscopy, and Foxborough Surgi- • Obstetric Christine Kimball, MSN, CRNA Center. • Out of OR Elizabeth Klaimy, MSN, CRNA locum • Thoracic Matthew Leblanc, MSNA, CRNA The CRNAs at BWH have full Caroline MacIntosh, MSN, CRNA FXB scope of practice, work in a collegial With our team of expert educators, Katelyn McGowan, MSN, CRNA - per diem care team model and are afforded our SRNAs are well prepared to enter Katherine McKemmie, MS, CRNA with multidisciplinary professional the work setting and provide anesthesia Gretchen Reed Napoli, per diem in FXB development opportunities. to a wide variety of patients. Our most Sian O’Leary, DNP, CRNA Additionally, BWH CRNAs can utilize recent SRNA graduates in 2021 are Regina Santamaria, BSN, CRNA FXB the support offered by the Senior Ada Genere, Caroline Smith, Stephanie Chelsea Smith, MSN, MS, CRNA Nurse Scientists, in the Department Slater, and Katherine McKemmie. Elizabeth Stocksdale, MSN, CRNA of Nursing, for research and quality Daniel Vasquez, MS, CRNA - locum improvement initiatives. Additionally, Viet Vo, MSN, CRNA our CRNAs play an essential role in William White, MS, CRNA the education and advancement of the Jackson Wild, DNAP, CRNA Student Registered Nurse Anesthetist Jennifer Wilson, DNP, CRNA (SRNA) Educational Program. Hannah Zentner, DNP, CRNA Kate Evangelista, DNP, CRNA, NEA-BC Brigham and Women’s Hospital has hosted SRNAs since 2005 from Northeastern University and, starting in 2017, from Boston College. The oversight of their clinical training is managed by two SRNA program directors, Lauren Anderson, MS, CRNA and Jackson Wild, DNAP, CRNA that coordinate specialty rotations while ensuring optimal case experiences and requirements. As part of their doctoral work, SRNAs complete scholarly projects in research or quality improvement with the sponsorship and support of members within the BWH anesthesia department. Based on the Anesthesia Care Team model, our accomplished anesthesiologists and CRNAs 18

Research Research in the Department of Anesthesiology, Perioperative and Pain Medicine (DAPPM) is an integral component of the Department’s mission and includes innovative and cutting edge basic, translational, and clinical research projects. Research in the department has an international reach and reputation, encompassing a broad range of topical areas (Table 1), making us one of the leaders nationally in NIH-funded research in Anesthesia. 85+ 30 research staff students grants awarded in the last annual cycle $40m annual research budget 193+ 250+ active clinical research protocols, departmentally peer-reviewed journal articles, editorials, supported studies and projects and chapters published annually Despite an increased call to clinical duty on the front lines against the COVID-19 pandemic, research efforts within the Department of Anesthesiology, Perioperative, and Pain Medicine persisted, transformed, and flourished in the past year. A revolution in the mechanisms for patient recruitment to trials was necessitated by conditions of social distancing. In the end, the innovation of instituting remote consent and prescreening by the Weiner Center for preoperative evaluation was developed, representing a more efficient and in some cases higher volume recruitment stream of patients to trials. Other researchers directly systematically measured the impact of social isolation on various health conditions such as chronic pain. After a brief period of transition, our basic scientists found new ways to get back into the lab and used their time to productively analyze and publish findings, as well as evaluate direction and gain new funding. Most importantly, our clinician-scientists in the intensive care units drove important research regarding the optimal care of patients with COVID-19, while simultaneously caring for these extremely sick patients under extreme pressure for their own safety and the safety of all staff in the ICUs. 19

Charles Serhan, PhD, DSc studies lipid Robert Edwards, PhD focuses his high- Kristin Schreiber, MD, PhD and her mediators and cellular mechanisms impact research on biopsychosocial team have identified psychosocial governing the resolution phase of pathways underlying central nervous and psychophysical characteristics of inflammation and infection. His system sensitization in patients patients that predict the development laboratory is devoted to structural with chronic pain. He has been of both more intense acute pain elucidation of novel mediators and involved in refining and standardizing and progression to chronic pain, as uncovered novel bioactive quantitative sensory testing in patients well as greater opioid consumption, molecules that are programmed for with pain, and in characterizing after surgical injury. She has biosynthesized during resolution phase the mechanisms that contribute applied this strategy of preoperative of inflammation which he coined to enhanced pain sensitivity and phenotyping within the context RCTs resolvins, protectins, and maresins. impaired pain modulation in patients of perioperative interventions, allowing These are known as the specialized with neuropathic, musculoskeletal, testing in enriched populations of proresolving mediators (SPM) a and inflammatory pain conditions. individuals at highest risk of pain superfamily of local autacoids that are His group’s recent work has identified persistence, to understand whether proven agonists of resolution. His team pain-related catastrophizing, a set pharmacologic interventions such as is defining the proresolving functions of negative cognitive/emotional regional anesthesia and ketamine, or of SPM that enhance clearance of responses to pain, and its neural behavioral interventions such as open- infections, reduce pain and shorten the correlates as a primary contributor label placebo, may differentially impact resolution interval of inflammation. to pain sensitization in patients with patients with different pain modulatory chronic back and joint pain. characteristics. Gregory Crosby, MD focuses his Matthew Spite, PhD leads a laboratory Sungwhan Oh, MD is a lead research on the impact of general focused on elucidating the roles investigator of microbiome anesthesia and surgery on the brain. of specialized pro-resolving lipid metabolomics laboratory (http:// Crosby and colleagues Deborah Culley, mediators (SPM) in controlling innate microh.bwh.harvard.edu) at CET&RI. MD (BWH/UPenn) and Zhongcong immunity and tissue repair following His research interest is on the Xie, MD, PhD (MGH) were the first to injury (http://spitelab.bwh.harvard. chemical mediators of microbiota– demonstrate that an uncomplicated edu). His laboratory has elucidated host–environment Interactions, general anesthetic without surgery that SPMs regulate immune cell focusing on the structures and produces long-lasting learning phenotypes that promote repair of immunomodulatory functions of impairment in old but not young tissue damage that occurs during novel symbiont-derived (‘endobiotic’) rodents and then in subsequent in ischemia, surgical injury, and infection. lipid mediators (sphingolipids and vitro and in vivo experiments showed His group has also found that glycolipids), by using high-sensitivity that anesthesia and surgery cause SPMs resolve chronic inflammation metabolomics platforms, diverse neuronal apoptosis, alter processing associated with metabolic dysfunction chemical/microbiological tools and of amyloid precursor protein, and in type 2 diabetes, obesity, and gnotobiotic animal models. With increase production, accumulation, cardiovascular diseases. Dr. Spite’s these multidisciplinary approaches, and aggregation of amyloid β, a protein laboratory discovered that SPMs the long-term goals of the group are implicated in the pathogenesis of enhance perfusion to tissues to comprehensively understand the Alzheimer’s disease. undergoing ischemia and has mechanisms of host–microbiota contributed to translational studies coevolution and to develop potential investigating local delivery of SPMs to targets that can be used in novel ways improve recovery following vascular to address diverse metabolic and surgery. immune diseases. 20

Jochen Muehlschlegel, MD, MMSc Christopher Connor, MD, PhD James Rathmell, MD, MBA focuses on focuses his research on studying focuses his research on the use the design and conduct of analgesic the impact of genetic variation on of C. elegans expressing calcium- drug and device trials at all stages of adverse cardiovascular events and sensitive fluorophores to determine drug development. He currently serves their significance on a functional level. how anesthetic gases and opioids as co-investigator for the NIH-funded He is the PI of the CABG Genomics impact communication between EPPIC-Net-CCC (Early Phase Pain study group, the TRANSCRIBE neurons, as well as how noxious Investigation Clinical Network Clinical (Transcriptomic Analysis of Left stimuli are processed in the absence Coordinating Center) at MGH/BWH Ventricular Gene Expression) study, and presence of different drugs within aimed at establishing and overseeing and the Genomics of postoperative this model system. The Connor lab processes to dramatically increase the Atrial Fibrillation study. His lab employs hypothesizes that a breakdown in efficiency and quality of multicenter whole-genome RNA-sequencing to organized communication in networks clinical trials of pain treatments. The characterize sex differences in the of neurons forms the fundamental EPPIC-Net project brings a novel and human transcriptional response to basis of the anesthetized state, critically important initiative in the myocardial ischemia and to identify and they aim to characterize the furthering of pain research, increasing sex-biased genomic loci that contribute exact nature of this breakdown and the number and quality of pain trials to variation in expression levels of RNA the subsequent recovery from it and accelerating the development after ischemia, namely expression that underlie the induction of and of information about pain and quantitative trait loci (eQTLs). awakening from clinical anesthesia. personalized pain treatments in order to reduce the suffering and disability associated with the current epidemic of chronic pain. Jinjun Shi, MD’s lab involves a highly Jeffrey Karp, PhD’s laboratory focuses Richard Urman, MD, MBA focuses his interdisciplinary combination of on the process of medical problem NIH-funded clinical research on acute nanotechnology, RNA delivery, and solving and the implementation of a and chronic pain. His research group immunotherapy for disease treatment multi-disciplinary investigation towards has focused on a balanced approach such as cancer and atherosclerosis. the development of bioengineered to postoperative pain management For instance, the activation of specific medical solutions. His work leverages for surgical patients to prevent signaling pathways in macrophages tools including bioinspiration to bring persistent post-operative opioid use. has been shown to promote the in new ideas and radical simplicity — He has designed a Multi-faceted progression of atherosclerosis, the art and discipline of reducing a persistent Opioid use Prevention which gives rise to cardiovascular problem to its essence. This tool has Program (MOPP) to support safer disease and stroke. Despite its been harnessed to develop therapeutic opioid prescribing, self-administration potential in combating atherosclerotic strategies to combat inflammatory and monitoring, and reduction of vascular disease, the inhibition bowel disease and arthritis that are persistent opioid use and opioid of pro-atherogenic macrophage advancing towards clinical studies. misuse for patients transitioning to pathways has been challenging. Dr. Additionally, Prof Karp demonstrated the community setting after major Shi and colleagues provided proof- that a biodegradable and elastic orthopedic surgery. His NSF-funded of-principle evidence that silencing adhesive glue can seal holes in high work focuses on collaborative research a plaque-destabilizing macrophage pressure dynamic tissues including to develop novel Computational molecule CaMKIIγ by targeted blood vessels and myocardium and Methods for Continuous Objective siRNA nanoparticles can improve can rapidly affix fully biodegradable Multimodal Pain Assessment Sensing phagocytosis of apoptotic cells patches inside a beating heart. System (COMPASS). (efferocytosis), decrease necrotic core area, increase fibrous cap thickness, and promote plaque stability. 21

Research activities Areas of research focus 1 Basic Clinical Translational Identifying novel bioactive Resolution of Novel interventions for chronic Opioid-related disorders mediators, pathways, and inflammation pain cellular targets critical in activating resolution of Nanomedicine COVID prediction modeling and Variation in pain processing inflammation and their relation to human disease. treatment between individuals 2 Genetic studies Psychosocial Interventions for Perioperative genetic and Understanding the mechanisms acute and chronic pain genomic predictors of disease of host–microbiota coevolution and to develop potential targets Neuroscience Critical care medicine New anesthesia delivery and that can be used in novel ways to and pain (cardiac, pulmonary, infectious monitoring address diverse metabolic and disease, reanimation) immune diseases.  Neuroimaging Outcome comparative studies Blood transfusion 3 (data mining) and establishing a data warehouse Designing and developing therapeutic nanoparticle Stem cell Neuroimaging ARDS treatment technologies for medical research applications and gaining a fundamental understanding Mechanisms of Biomedical engineering New medical devices of the biological identity of anesthesia and nanoparticles anesthetics 4 Anesthetic Complementary and alternative New drug trials toxicity medicine Pioneering the use of advanced epidemiological techniques Major grants awarded in 2020-21 (amounts > $100k), out of 30 grants applied to large, routinely total, for a total of $19,720,862 over their entire budget period. collected healthcare utilization data to evaluate the safety of Parent PI Title - Parent Immediate Sponsor Mechanism medications in pregnancy Charles Evaluating Resolution NIH-National R 5 Serhan, PhD, Mechanisms for Institutes of Health DSc Infectious Inflammation Examining the molecular transcriptome of ischemia Jeffrey Karp, Development of oral Novo Nordisk Industry reperfusion injury in the human PhD heart drug delivery platforms 6 Jochen Genomics of Post-op NIH-National RO1 Muehlschlegel, Atrial Fibrillation After Institutes of Health Using psychosocial and MD, MMSc Cardiac Surgery psychophysical characteristics of patients to predict the Jinjun Shi, MD Systemic RNA Delivery NIH-NCI National RO1 development of chronic pain, to Tumors Cancer Institute as well as greater opioid consumption, after surgical Jinjun Shi, MD Long-Acting NIH-National RO1 injury. RNAi Therapy for Institutes of Health Atherosclerosis and Insulin Resistance Nitin Joshi, A self-assembled NIH-National RO1 PhD hydrogel with tunable Institutes of Health drug release kinetics for preventing osteoarthritis in active joint. Christopher A sequenced strategy Johns Hopkins U Gilligan, MD, for improving outcomes University MBA in patients with knee osteoarthritis pain (SKOAP) 22

COVID Message from The Chair Our team stepped forward in countless ways to meet the new and ever-changing demands of the COVID pandemic while providing direct patient care and leadership throughout the organization. Everyone came together to ensure that our patients and colleagues were as safe as possible throughout. From stepping in to care for critically ill patients in COVID ICUs and the operating rooms to finding innovative ways to sanitize masks and increase our supplies of personal protective equipment, everyone found a way to contribute. My sincere thanks to the entire team for seeing us through these difficult years. COVID Taskforce Sibinka Bajic, MD, PhD Brian Bateman, MD, MSc Evan Blaney, MD Sascha Beutler, MD, PhD Richard Cornell Deborah Culley, MD Sunil, Eappen, MD Kathleen Evangelista, CRNA Hugh Flanagan, MD Christopher Gilligan, MD, MBA Philip Hartigan, MD Jill Lanahan, MD Robert Lekowski, MD, MPH Jochen Muehlschlegel, MD, MMSc Luigino Nascimben, MD, PhD Ju-Mei Ng, MD Louisa Palmer, MD, MBBS Sian O’Leary, DNP, CRNA Carmelita Pisano, MD David Preiss MS, MD, PhD Tara Carey, MD James Rathmell, MD David Shaff, MD Stanton Keith Shernan, MD Douglas Shook, MD Nelson Thaemert, MD Joshua Vacanti, MD Martin Zammert, MD 23

Center for Pain Medicine The Division of Pain Medicine at Brigham & Women’s Hospital is a multidisciplinary academic pain medicine division that excels in clinical care, medical education, and research activities. The division comprises an interdisciplinary group of 19 clinicians with primary training in anesthesiology, neurology, psychology, psychiatry, addiction medicine, emergency medicine and palliative care, as well as a supporting team of a nurse practitioners and physician’s assistants, nurses, medical assistants, radiology technicians, and administrative staff. We have six locations and roughly 35,000 annual patient visits. The Division Chief is Chris Clinical staff members collaborate Achievements Gilligan, MD, MBA. with healthcare providers from many disciplines to provide comprehensive 1 * The leadership team also includes: outpatient and inpatient care to patients with acute and chronic pain conditions. Serving as NIH study section Jason Yong, MD, MBA* An evidence-based approach is members Associate Division Chief utilized in conjunction with advanced techniques to help patients achieve 2 Menrika Cherenfant, MHA, MPA the best possible pain control and Senior Director of Pain Medicine return of function. Approaches include Serving as editors in chief, comprehensive interventional spine editors, editorial board members, Michael Ferrick, DNP services, medication management, or reviewers for over 40 Regional Nurse Director of Pain Medicine physical therapy, acupuncture, opioid professional journals, including and Spine Center therapy screening, cognitive behavioral Anesthesiology, Neuromodulation, therapy, biofeedback, and mindfulness Pain Practice, and Clinical Journal Mohammed Issa, MD meditation. We perform a large volume of Pain. Fellowship Director and Medical Director of advanced interventions including of Pain Medicine at Brigham and Women’s implantation of spinal cord stimulators, 3 Faulkner Hospital dorsal root ganglion stimulators, intrathecal drug pumps, and Providing national leadership in Susan Lim, MD interspinous spacers. We also perform developing pain management Associate Fellowship Director vertebral augmentation procedures protocols and education materials such as kyphoplasty and minimally (e.g., Bonica’s Management of Ehren Nelson, MD invasive decompressions for spinal Pain, MGH Pain Handbook, etc); Director of Education stenosis (MILD procedure). 4 Brenda Lee, MD Faculty members serve in leadership Director of Quality and Safety roles on the American Board of advocating for improved pain Anesthesiology (ABA) and participate in management at the national and Pritesh Topiwala, MD writing questions for the Pain Medicine local media outlets; and Medical Director of Pain Medicine at Certification Examination. In addition, Foxborough several faculty members have been 5 recognized as leaders in pain medicine David Janfaza, MD and pain research, and participate in a Participating in national expert Medical Director of Pain Medicine at South wide range of activities, including: panels of pain and opioid Weymouth management. Victor Wang, MD, PhD 6 Medical Director of Pain Medicine at Milford Hospital Suggest mechanisms for program evaluation and metrics of success *Dr. Yong stepped in to serve as Interim Division Chief in late 2021, when Dr. Gilligan assumed a new role as Associate Chief Medical Officer for Perioperative and Procedural Services 24

COVID Response the Hale clinic for ambulatory COVID proposal for a Pain Medicine Clinical patients that was equipped with Trials Center that we have shared with The COVID-19 pandemic strained and appropriate PPE. select donors. stressed the system at the Pain Center on multiple levels. Patient access was Ambulatory scheduling Innovations severely limited without the ability optimization to perform elective in-person visits. This year, our team helped to Furthermore, staffing was an issue Brigham Health initiated an effort to lead the design and launch of the with some staff being pulled to cover standardize ambulatory care across Brigham & Women’s Spine Center with the ICU’s and others unable to come the system and disciplines. The Center multidisciplinary teams staffed by on site for health or family concerns. for Pain Medicine started this process neurosurgeons, orthopedic surgeons, We had thousands of patients waiting in the Spring of 2021. We started with physiatrists and pain medicine for appointments to have medications standardizing visit types across all of specialists. refilled and hundreds looking for our sites and are now implementing interventions to improve their pain. universal templates for scheduling Our clinical trials work including each E&M session. The next phase of leading the pivotal clinical trial that We prioritized patient access, and this process will be creating a universal resulted in FDA approval and US spearheaded by Menrika Cherenfant, order that can be used to schedule commercial of a novel, restorative, the Center for Pain Medicine was procedures at all of our sites which will implantable neurostimulator to treat able to initiate telemedicine visits in include the necessary documentation severe, refractory, chronic low back an efficient and robust manner. The for prior authorization. We also worked pain. logistics involved buying cameras and on ensuring we have a standardized microphones, creating virtual templates, division wide anticoagulant guideline for Drs. Edgar Ross and Robert Jamison teaching appropriate compliance, our clinical team to reference and utilize continue their work on App based and rescheduling all the patients into at time of booking for an intervention. system for evaluation and treatment telemedicine appointments. This of patients with chronic pain and other endeavor was incredibly successful with Future plans medical conditions. the telemedicine appointments going from 0 in February 2020 to 462 in March The Center for Pain Medicine looks Members of the division have created and 1649 in April. We also maintained to continue providing exemplary care a curriculum for procedural training access for emergency procedures for patients and service to referring of fellows and residents using high to be performed at the Center for providers. Each site will include an fidelity simulation cadaver-like models Pain Medicine. These procedures Advance Practice Provider to help that allow for extremely high-fidelity included intrathecal pump refills and decrease access for follow-ups and simulation of common fluoroscopy interventions for patients in extremis. provide improved communication guided pain medicine interventions. We and continuity of care. We are also conduct these sessions several times The staffing issues were handled on moving closer to launching a single, during the course of the fellowship year an individual level to balance personal centralized pain medicine call center and include pain medicine fellows from situations and personnel requirements. that can service all six of our sites with Massachusetts General Hospital and Menrika Cherenfant organized rotating patient questions, scheduling, and a Beth Israel Deaconess Medical Center. coverage for the administrative staff to Triage Nurse. We are finalizing patient Feedback from the fellows has been work from home to limit the staff from education brochures on the various extremely positive, and we conduct pre potential exposure to COVID. We used interventions we do that we plan to and post evaluations of their procedural emergency funding to purchase laptops incorporate in our visit summaries, performance before and after the for remote use and set-up Doximity to our website and also through Patient simulation sessions. help make secure/compliant phone Gateway. Innovation and research calls. Pain fellows and select attending continue to be a top priority and we look With the recent advances in physicians were deployed to the ICU to continue our growth in clinical trials technology related to high-definition to decrease the demand and workload and new procedures. 360-degree cameras, computer of the residents. Attending physicians processing power and the readily worked mostly remotely from home Philanthropy available smart-phone compatible VR while a few staffed the Center for headsets, our fellowship has capitalized Pain Medicine to perform emergency The Center for Pain Medicine received on this progress and developed a procedures. $68,100 in donations from twelve Virtual Reality and Immersive Education donors this year. Gifts ranged from Platform for our fellowship. Under For patients who were diagnosed $50 to $20,000. We continue to work the leadership of Dr. Jason Yong and with COVID but still required in-person closely with the staff at the Brigham Dr. Ehren Nelson, in conjunction with evaluation or emergency procedures, Development Office and we wrote a Interventional Pain Simulation Center, we established 1 session per week at we have the ability to make 360 VR recordings of fellows performing 25

procedures in the Simulation Center BWH Pain: Virtual Visits (3/18/2020 - 9/30/2020) that are then processed and returned to each individual fellow for personal 1800 1649 review. This gives them the ability have 1600 a fully immersive experience to be 1400 1507 1503 1486 1482 an “observer” in the room when they 1399 performed the procedure. This allows 1200 the fellows to review their technique and to identify many aspects of their 1000 performance that are not often visible 800 without this opportunity to review. Second, we have been compiling a 600 library of interventional procedures 400 462 filmed in full 360 VR performed by staff in the Simulation Center to provide the 200 same immersive aspect that allows 0 0 fellows to watch attendings perform Feb March April May June July Aug Sept procedures. Vertiflex and MILD The gap between interventional pain procedures and surgery includes a small patient population suffering from lumbar spinal stenosis who are refractory to simple steroid injections and physical therapy but are not surgical candidates due to comorbidities and/or advanced age. Recently, two devices have been developed and approved to decompress the spinal canal in patients with spinal stenosis using minimally invasive techniques. We have positioned the Center for Pain Medicine as a Center Of Excellence for the Vertiflex Superion spinous process spacer and the Minimally Invasive Lumbar Decompression procedures. Dorsal Root Ganglion Stimulation The field of neuromodulation has benefited from significant innovation over the past decade. Much of the innovation has revolved around software and waveform manipulation, but a major development in hardware has been the advent of a novel type stimulator which allows a thin electrode to be implanted directly over the dorsal root ganglion. This allows us to directly target a specific distribution of pain and allows for improved pain relief and functionality for many patients with severe, refractory, focal neuropathic pain. 26

Support our work Each year, thousands of people entrust the Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women’s Hospital with their care, due to our wide range of clinical anesthesia services, including pain management after surgery and during labor. Our nationally-recognized Center for Pain Therapy and Research combines comprehensive clinical services, innovative technology, and leading-edge research programs. Many patients turn to us because of our long history of medical firsts and our reputation for attracting the finest physicians and researchers in the country. One of the primary reasons we have been able to build such a strong department is because of donors like you. When you make a gift to the Department of Anesthesiology, Perioperative and Pain Medicine, you enable our specialists to provide comprehensive, leading-edge care. Support from patients, friends and institutional donors helps us train staff and assists patients with treatment costs. Donor support also funds promising research that transforms and saves lives. For more information, or if you are interested in making a gift to the Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women’s Hospital or to a specific physician or scientist, please contact: Kiran Rai Director, Gift Administration [email protected] 617.424.4321 Development Office Brigham and Women’s Hospital 116 Huntington Avenue, Third Floor Boston, MA 02116-5749 Brigham Anesthesia Alumni Every month we send out a department newsletter that includes updates and stories from current staff and alumni. If you would like to join our alumni communications list or send us an update, please email [email protected]. Leadership Tara Carey, MD Richard Cornell, MBA James P. Rathmell, MD, MBA Associate Vice Chair, Faculty Development Executive Administrator Department Chair Kristin Schreiber, MD, PhD Menrika Cherenfant MHA, MPA Luigi Nascimben, MD, PhD Associate Vice Chair, Research Senior Administrative Director-Pain Vice Chair, Clinical Operations Medicine Carmen Pisano, MD Christopher Gilligan, MD, MBA Associate Vice Chair, Clinical Operations James Webber, Jr. Vice Chair, Strategy Administrative Director David Shaff, MD Jochen Muehlschlegel, MD, MMSc Brigham and Women’s Faulkner Hospital, Laura Curley, MBA Vice Chair, Research Department Chief Finance Director Stanton Shernan, MD David Hepner, MD, MPH Cynthia O’Donnell, MHA Associate Vice Chair, Finance Director, Weiner Center for Preoperative Director of Education Evaluation Raquel Bartz, MD, MMCi Dominique Arce, MD, MPH Associate Chair, Critical Care Medicine William Dylewsky, MD Director of Diversity Equity and Inclusion Brigham and Women’s Foxborough, Medical Director

Department of Anesthesiology, Perioperative and Pain Medicine • 75 Francis Street • Boston, MA 02115 Contact Us • [email protected] | 617.732.8210 Follo28w Us • twitter.com/BrighamAnes | instagram.com/brighamanesthesia/