ALPS GLOBEMEDIC SDN BHD ALPS’s Healthcare Group www.alpsmedical.com
ALPS Medical Centre Accreditation (2019): Proposed Accreditation: Managed by TMC Global Holdings Sdn Bhd Kuala Lumpur, Malaysia www.alpsmedical.com
Member of ALPS Medical Centre Ministry of Health, Malaysia since 2016 Licensed Private Ambulatory Care Centre Under Private Healthcare Facilities and Services Act 1998 www.alpsmedical.com
Medical Centre License & Award Certificate
ALPS Medical Clinic ALPS Wellness Centre (Genting Highlands) (Genting Highlands) Ministry of Health, Malaysia since 2018 Licensed Private Medical Clinic Under Private Healthcare Facilities and Services Act 1998 www.alpswellness.com
AMANDREY Aesthetics Centre Ministry of Health, Malaysia since 2010 (Georgetown, Pulau Pinang) Licensed Private Medical Clinic Under Private Healthcare Facilities and Services Act 1998
Precision & Preventive Medicine www.alpsmedical.com
Collaborations with World-Class Research Centers www.alpsmedical.com
Attracts the BEST scientists in the world www.alpsmedical.com
The History of Stem Cell Therapy www.alpsmedical.com
▪ SELF-RENEWAL: stem cells can renew themselves almost indefinitely. This is also known as proliferation. ▪ DIFFERENTIATION: stem cells have the special ability to differentiate into cells with specialized characteristics and functions. ▪ UNSPECIALIZED: stem cells themselves are largely unspecialized cells which then give rise to specialized cells. www.alpsmedical.com
Quality Control From sheep raised for 40 generations (surpasses even FDA’s 25 to 30 generation rule) 80th. Generations www.alpsmedical.com
Free from diseases (no contamination) Reared in closed-colony (no risk of infection from other species) www.alpsmedical.com
Preserved at - 196°C, proteins are retained Effectively No targets Preservatives specific or Stabilizers disease or disorders An Advanced natural treatment for pre-mature aging www.alpsmedical.com
PRODUCTS OF ANTI-AGING www.alpsmedical.com
CÉLEBRE P-CELL SOFTGEL Registration No. ▪ MAL 14075005NC Packing Ingredients ▪ 03 X 10 softgels per pack Advisable for ▪ Sheep Placenta : 400mg ▪ Marine Peptide : 240mg ▪ (400mg with concentration of 50:1 equivalent to 20,000mg) ▪ From ages 35 & above. ▪ Menopause, acne patients, hormone imbalance, anti-aging patients. ▪ DO NOT Recommended for Thyroid & Cancer patients. After Treatment ▪ Body may experience being more energetic, skin tone may glow & be brighter, breast may feel more firm, skin more moisturized, finer, pores feel more tighten. www.alpsmedical.com
CÉLEBRE PLACENTA SHEEP (CPS) Registration No. ▪ NOT 191103900K Packing Ingredients ▪ 02ml X 12 vials per set Advisable for ▪ Sheep Placenta Extract : 240mg/ vial ▪ From ages 35 & above. ▪ Menopause, acne patients, hormone imbalance, anti- aging patients. ▪ DO NOT Recommended for Thyroid & Cancer patients. After Treatment ▪ Body may experience bring more energetic, skin tone may glow & be brighter, breast may feel more firm, skin more moisturized, finer, pores feel more tighten. www.alpsmedical.com
CÉLEBRE PLACEN (CLP) Registration No. ▪ NOT 191103898K Packing Ingredients ▪ 05ml X 08 vials per set Advisable for ▪ Sheep Placenta (Lyophilized) : 800mg/ vial After Treatment ▪ All ages. ▪ Menopause, acne patients, hormone imbalance, anti-aging patients. ▪ DO NOT Recommended for Thyroid & Cancer patients. ▪ Body may experience bring more energetic, skin tone may glow & be brighter, breast may feel more firm, skin more moisturized, finer, pores feel more tighten. ▪ Muscle Dystrophy patients feel much better, muscle grow and pain reduced. ▪ Body may experience gradual improvements. www.alpsmedical.com
CÉLEBRE CRYO PLACENTA (CCP) Registration No. ▪ NOT 191103903K Packing Ingredients ▪ 05ml X 08 vials per set Advisable for ▪ Fresh Frozen Rabbit Placenta stored in nitrogen -196° . After Treatment ▪ 10 million cells/ vial ▪ All ages, FEMALE ONLY. ▪ Menopause, acne patients, hormone imbalance, anti- aging patients. ▪ DO NOT Recommended for Thyroid & Cancer patients. ▪ Body may experience bring more energetic, skin tone may glow & be brighter, breast may feel more firm, skin more moisturized, finer, pores feel more tighten. ▪ Muscle Dystrophy patients feel much better, muscle grow and pain reduced. ▪ Body may experience gradual improvements. www.alpsmedical.com
PRODUCTS OF SPECIFIC ORGANS www.alpsmedical.com
Registration No. CÉLEBRE FETAL TOTALE (CFT) Packing Ingredients ▪ NOT 191103899K Advisable for ▪ 02ml X 12 vials per set ▪ Sheep Fetal Extract : 240mg/ vial After Treatment ▪ All ages. ▪ For general organs repair. ▪ Feel energetic & refreshed, organs being repaired (advisable to do a medical check up after 3rd. month) to compare the “BEFORE & AFTER” results. ▪ Normally, high sugar levels & high blood pressure gradually reduce. www.alpsmedical.com
CÉLEBRE ORGAN SPECIFIC (COS) Registration No. ▪ NOT 191103897K Packing Ingredients ▪ 05ml X 08 vials per set Advisable for ▪ Sheep organ cells (Lyophilized) : 800mg/ vial ▪ All ages. ▪ Male rejuvenation, Female rejuvenation, general organs repair. ▪ Highly recommended for patients with organs problem or disease. After Treatment ▪ Feel energetic & refreshed, organs being repaired (advisable to do a medical check up after 3rd. month) to see the “BEFORE & AFTER” results. ▪ Improvement on every organs. www.alpsmedical.com
Registration No. CÉLEBRE CRYO CELL (CCC) Packing Ingredients ▪ NOT 191103896K Advisable for ▪ 05 Million : 05ml X 08 vials per set After Treatment ▪ 10 Million : 05ml X 08 vials per set ▪ Fresh Frozen Rabbit Placenta stored in nitrogen -196° ▪ All ages. ▪ Male rejuvenation, Female rejuvenation, general organs repair. ▪ Highly recommended for patients with organs problem or disease. E.g. Cancer stage II & below, or rejuvenation patients. ▪ Feel energetic & refreshed, organs being repaired (advisable to do a medical check up after 3rd. month) to see the “BEFORE & AFTER” results. ▪ Improvement on every organs. www.alpsmedical.com
PRODUCTS OF SKIN REJUVENATION www.alpsmedical.com
CÉLEBRE COLLAGEN SKIN ELASTIN (CSE) Registration No. ▪ NOT 191103901K Packing ▪ 02ml X 12 vials per set Ingredients ▪ Peptide & factors : 240mg/ vial Advisable for ▪ All ages. ▪ Pigmentation, wrinkles, acne, oily skin, hot water scaled cases, chemical burns. After Treatment ▪ Pigment may lighten gradually, face may experience a ‘lift’, firmer, brighten, acne problems would reduce. www.alpsmedical.com
PRODUCTS OF BODY BRIGHTENING www.alpsmedical.com
CÉLEBRE PHYTOSTEM (CPM) Registration No. ▪ NOT 191103902K Packing ▪ 05ml X 08 vials per set Ingredients ▪ Non GMO wild soybean plant extract : 800mg Advisable for ▪ All ages. ▪ Whole body brightening, vegetarian patients. After Treatment ▪ Whole body skin tone will brighten. www.alpsmedical.com
PRODUCTS OF MESENCHYMAL STEM CELLS (MSCs) www.alpsmedical.com
MSCs are multipotent stem MESENCHYMALSourced from the Wharton’s cells which can derived into Jelly in the umbilical cord STEM CELLS different type of cells. Special delivery agents. They Enhances our external image can selectively recognize and aesthetically, hence the anti- actively migrate towards aging effect; naturally and specific signals and exert their literally. effects Immune Previledged
MSC Differentiation in Vitro Adipocytes (Oil red O) Osteocytes (Alizarin red) Insulin producing cells Smooth muscle cells(alpha SMA) Adipocytes (Oil Red O) Cardiomyocytes (connexin 43) Neural & Schwann cells (neurite formation) www.alpsmedical.com
Sheep as osteoarthritic knee model – treatment with chondro-induced MSCs injection BMSCs vs ADSCs Surgically-removed ACL & Normal OA knee (control) meniscus Osteoarthritis was induced successfully after 6 weeks of meniscectomy and complete resection of ACL in sheep knee joint BMSC treated knee after 6 Tracking of injected cell in the COL- II expression in the Regenerated cartilage weeks regenerated cartilage using PKH- regenerated cartilage (Safranin O Staining) 26 dye www.alpsmedical.com
Nude rats as sciatic nerve defect model – treatment with tissue engineered nerve Human tissue engineered nerve Original Sciatic nerve Tissue engineered nerve www.alpsmedical.com
Treatment of critical bone defect in rabbit model Day 1 Day 90 www.alpsmedical.com
Primates as resorbed alveolar bone models – treatment with tissue engineered bone & osteo-induced stem cell injection Haematoxylin & Eosin www.aRlapisesd malveeoladr biocneal.com
Rabbit models–treatment with tissue engineered cornea www.alpsmedical.com
Bladder engineering – 6 weeks post-implantation PLGA scaffold PLGA scaffold seeded with cells Pressure (cmH20) 40 30 20 10 0 0 0.5 1 1.5 2 Urodynamic (normal pressure resumed) Gross appearance ( stone formation) Regeneration of 3 urothelial layers Tissue engineered bladder 8 weeks Ultrasound of regenerated bladder post implant www.alpsmedical.com
CÉLEBRE MESENCHYMAL STEM CELLS (MSC) Registration No. ▪ 10 Million : 2.5ml X 01 vial per set (Both knee) Packing Ingredients ▪ Umbilical cord : Wharton’s Jelly Advisable for ▪ All ages. ▪ Vascular repair, Bone repair, Joint pain,... After Treatment ▪ Feel energetic & refreshed, organs being repaired (advisable to do a medical check up after 3rd. month) to see the “BEFORE & AFTER” results. ▪ Improvement on every organs. www.alpsmedical.com
CÉLEBRE MESENCHYMAL STEM CELLS (MSCs) Registration No. ▪ 50 Million : 2.5ml X 01 vial per set Packing ▪ Umbilical cord : Wharton’s Jelly Ingredients Advisable for ▪ All ages. ▪ Highly recommended for patients with heart problems, Liver problems, Fatty liver, Diabetes type II, Kidney problems, Vascular repair,... After Treatment ▪ Feel energetic & refreshed, organs being repaired (advisable to do a medical check up after 3rd. month) to see the “BEFORE & AFTER” results. ▪ Improvement on every organs. www.alpsmedical.com
CÉLEBRE MESENCHYMAL STEM CELLS (MSC) Registration No. ▪ 200 Million : 2.5ml X 01 vial per set Packing ▪ Umbilical cord : Wharton’s Jelly Ingredients Advisable for ▪ All ages. ▪ Highly recommended for patients with heart problems, Liver problems, Fatty liver, Diabetes type II, Kidney problems, Vascular repair,... After Treatment ▪ Feel energetic & refreshed, organs being repaired (advisable to do a medical check up after 3rd. month) to see the “BEFORE & AFTER” results. ▪ Improvement on every organs. www.alpsmedical.com
Celestialab Accreditation (2018): Proposed Accreditation: Managed by Celestialab Sdn Bhd Kuala Lumpur, Malaysia www.celestialab.com
www.celestialab.com
www.alpsmedical.com
Whole Genome Sequencing (WGS) www.alpsmedical.com
What We Offer at MyGenome vs. What’s in the Current Market: MyGenome Current Market Whole Genome Sequencing (WGS) Whole Exome Sequencing (WES) Function Focuses on the entire genome sequences Focuses on the protein coding sequences only Interpreting Length Can take advantage of longer reads Anything longer than 200 paired end reads will be wasted Coverage Total Size Whole genome Only 1% of the genome Scoring 3.3 billion base pairs 30 million base pairs WGS scores better for completeness of disease WES tends to miss between 0.42% to 24.44% of relevant genes data False-negative Possibility 0.022% 2.17% (%) www.alpsmedical.com
WGS and cancer ✓ Comprehensively explore all types of genomic alterations in cancer can clarify the underlying carcinogenesis and achieve molecular sub‐classification of cancer, which facilitates discovery of genomic biomarkers and personalized cancer medicine. ✓ About 5 to 10 percent of all cancers are caused by known inherited gene mutations. ✓ These mutations are passed down from generation to generation. ✓ Through WGS, patients are able to assess their risk for many types of cancer ✓ detect early cancers or, better yet, prevent cancers from ever forming. www.alpsmedical.com
RM 6,400.00 ▪ Fibrochondrogenesis ▪ Pineal hyperplasia AND diabetes mellitus syndrome ▪ Fructose-biphosphatase deficiency ▪ Popliteal pterygium syndrome Tertiary analysis (100 traits) includes: ▪ Gamma-aminobutyric acid transaminase deficiency ▪ Porphobilinogen synthase deficiency ▪ Gastric cancer ▪ Post-traumatic stress disorder ▪ Acute recurrent myoglobinuria ▪ Glaucoma ▪ Progressive external ophthalmoplegia with mitochondrial DNA deletions ▪ Afibrinogenemia ▪ Gorlin syndrome ▪ Progressive supranuclear palsy ▪ Alpha-1-antitrypsin deficiency ▪ Hemoglobin ▪ Proline dehydrogenase deficiency ▪ Angiopathy ▪ Hypercholanemia ▪ PTEN hamartoma tumor syndrome ▪ Aniridia ▪ Hyperekplexia ▪ Renal adysplasia ▪ Apocrine gland secretion ▪ Hyperglycinuria ▪ Retinitis pigmentosa ▪ Atopy ▪ Hyperphosphatasemia with bone disease ▪ Sandhoff disease ▪ Autism ▪ Hypertriglyceridemia ▪ Schaaf-yang syndrome ▪ Baldness ▪ Interleukin 1 receptor antagonist deficiency ▪ Sepsis ▪ Benign familial neonatal seizures 1 ▪ Isolated coronal synostosis ▪ Short QT syndrome ▪ C3 deficiency ▪ Jackson-Weiss syndrome ▪ Spinocerebellar ataxia ▪ Calcium oxalate urolithiasis ▪ Kawasaki disease ▪ Stickler syndrome ▪ Carnitine palmitoyl transferase II deficiency ▪ KCNQ2-related disorders ▪ Stroke ▪ Catecholaminergic polymorphic ventricular tachycardia ▪ Leukocyte adhesion deficiency ▪ Succinate-semialdehyde dehydrogenase deficiency ▪ Celiac disease ▪ Leukoencephalopathy with vanishing white matter ▪ Sucrase-isomaltase deficiency ▪ Cerebrooculofacioskeletal Syndrome ▪ Leydig cell agenesis ▪ Systemic sclerosis ▪ Chondrodysplasia ▪ Mandibuloacral dysplasia with type A lipodystrophy ▪ Taste ▪ Choroidal dystrophy ▪ MASP2 deficiency ▪ Tay-Sachs disease ▪ Chronic obstructive pulmonary disease ▪ Microcephaly ▪ Townes syndrome ▪ Coffee ▪ Migraines ▪ Transferrin variant c1/c2 ▪ Congenital disorder of glycosylation type 1t ▪ Mitochondrial DNA depletion syndrome ▪ WFS1-related spectrum disorders ▪ Congenital hypothyroidism ▪ Multiple myeloma ▪ Wolcott-Rallison dysplasia ▪ Congenital myasthenic syndrome ▪ Myelofibrosis ▪ Crouzon syndrome ▪ Nephropathic cystinosis ▪ Deficiency of galactokinase ▪ Nephrotic syndrome ▪ Diaphyseal medullary stenosis with malignant fibrous histiocytoma ▪ Neuroblastoma ▪ Digital clubbing ▪ Non-alcoholic fatty liver disease ▪ Duchenne muscular dystrophy ▪ Oguchi’s disease ▪ Earwax ▪ Osteoglophonic dysplasia ▪ Ectrodactyly ▪ Osteoporosis ▪ Epidermolysis bullosa simplex ▪ Patterned dystrophy of retinal pigment epithelium ▪ Familial amyloid nephropathy with urticaria AND deafness ▪ Permanent neonatal diabetes mellitus ▪ Familial atypical mycobacteriosis ▪ Perrault syndrome peters anomaly ▪ Familial cancer of breast ▪ Familial hemophagocytic lymphohistiocytosis ▪ Familial restrictive cardiomyopathy ▪ Farber’s lipogranulomatosis www.alpsmedical.com
RM 11,400.00 ▪ Anorexia nervosa ▪ Benign familial neonatal seizures 1 Tertiary analysis (669 traits) includes: ▪ Antenatal Bartter Syndrome ▪ Beta-D-mannosidosis ▪ 4-Alpha-hydroxyphenylpyruvate hydroxylase deficiency ▪ Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis ▪ Bietti crystalline corneoretinal dystrophy ▪ Abdominal aortic aneurysm ▪ Bifunctional peroxisomal enzyme deficiency ▪ Abetalipoproteinemia ▪ APC-associated polyposis disorders ▪ Abnormality of brain morphology ▪ Bipolar disorder ▪ ABO blood group ▪ Aplastic anemia ▪ Accelerated tumor formation ▪ Bladder cancer ▪ Achondrogenesis ▪ Apocrine gland secretion ▪ Achromatopsia ▪ Blau syndrome ▪ Acquired immunodeficiency syndrome ▪ Apolipoprotein A-II deficiency ▪ Acrocephalosyndactyly type ▪ Blood group ▪ ACTN3 deficiency ▪ Appearance/Eye color ▪ Acute lymphoblastic leukemia ▪ Bone mineral density variation quantitative trait locus ▪ Acute recurrent myoglobinuria ▪ Arterial calcification of infancy ▪ Addiction ▪ Brachydactyly ▪ Afibrinogenemia ▪ Arteriohepatic dysplasia ▪ Ageing ▪ Brain small vessel disease with hemorrhage ▪ Age-related hearing impairment ▪ Arthritis ▪ Age-related macular degeneration ▪ Breast cancer ▪ AIDS ▪ Arthrogryposis ▪ Alcoholism ▪ Breast size ▪ Alkaptonuria ▪ Aspartylglycosaminuria ▪ Allan-Herndon-Dudley syndrome ▪ Brugada syndrome ▪ Allergies ▪ Asthma and atopy ▪ Alopecia areata ▪ Budd-Chiari syndrome ▪ Alpha-1-antitrypsin deficiency ▪ Ataxia with oculomotor apraxia ▪ Alpha-methyl acyl-CoA racemase deficiency ▪ C3 deficiency ▪ Alport syndrome ▪ Atelosteogenesis ▪ ALS2-related spectrum disorders ▪ Calcium oxalate urolithiasis ▪ Alzheimer’s disease ▪ Atherosclerosis ▪ Amelogenesis imperfecta ▪ Cannabis ▪ Amyotrophic lateral sclerosis ▪ Atopic dermatitis ▪ Aneurysm ▪ Carcinoma of pancreas ▪ Anger ▪ Atopy ▪ Angiopathy ▪ Cardio-facio-cutaneous syndrome ▪ Aniridia ▪ Atransferrinemia ▪ Ankylosing spondylitis ▪ Cardiomyopathy ▪ Anophthalmia ▪ Atrial fibrillation ▪ Cardiovascular phenotype ▪ Atrial septal defect ▪ Carnitine palmitoyl transferase II deficiency ▪ Atrioventricular septal defect ▪ Caspase-8 deficiency ▪ Attention deficit hyperactivity disorder ▪ Cataracts ▪ Atypical hemolytic uremic syndrome ▪ Catecholaminergic polymorphic ventricular tachycardia ▪ Autism ▪ Caudal dysgenesis syndrome ▪ Autoimmune lymphoproliferative syndrome ▪ Celiac disease ▪ Autoimmune thyroid disease 3 ▪ Centromeric instability of chromosomes 1 ▪ Autosomal recessive polycystic kidney disease ▪ Cerebellar ataxia ▪ Axillary odor ▪ Cerebral autosomal dominant arteriopathy with subcortical infarcts and ▪ Bacteremia ▪ Baldness leukoencephalopathy ▪ Bardet-biedi syndrome 2/6 ▪ Cerebral palsy spastic quadriplegic ▪ Basal cell carcinoma ▪ Cerebrooculofacioskeletal Syndrome ▪ Basal laminar drusen ▪ Cervical cancer ▪ Behavior disorder ▪ Char syndrome ▪ Behçet's disease ▪ Charcot-Marie-Tooth www.alpsmedical.com
Tertiary analysis (669 traits) includes: ▪ Cortisone reductase deficiency 2 ▪ Drug abuse ▪ Craniosynostosis ▪ Duchenne muscular dystrophy ▪ Chitotriosidase deficiency ▪ Crohn disease ▪ Ductal breast carcinoma ▪ Cholesterol ▪ Crouzon syndrome ▪ Dyskeratosis congenita ▪ Cholinesterase Inhibitors ▪ Curry-Hall syndrome ▪ Dyskeratosis congenita autosomal dominant ▪ Chondrodysplasia ▪ Cutis Gyrata syndrome of Beare and Stevenson ▪ Dyslexia ▪ Chorionic plate inflammation ▪ Cystic fibrosis ▪ Dyssegmental dysplasia ▪ Choroidal dystrophy ▪ Cystinosis ▪ Dystonia ▪ Chronic infantile neurological ▪ Cystinuria ▪ Early infantile epileptic encephalopathy ▪ Chronic kidney disease ▪ Cytochrome-c oxidase deficiency ▪ Early-onset familial Alzheimer Disease ▪ Chronic obstructive pulmonary disease ▪ Decreased blood alpha-hydroxy isovalerate levels ▪ Earwax ▪ Cleft palate ▪ Deep vein thrombosis ▪ Ectrodactyly ▪ Cockayne syndrome ▪ Deficiency of aromatic-L-amino-acid decarboxylase ▪ Eczema ▪ Coffee ▪ Deficiency of galactokinase ▪ Educational attainment ▪ Collagen VI-related myopathy ▪ Deficiency of phosphoserine phosphatase ▪ Ehlers-Danlos syndrome ▪ Colon cancer ▪ Dementia ▪ Ehlers-Danlos syndrome ▪ Colorectal cancer ▪ Dental caries ▪ Elliptocytosis ▪ Colostrum secretion ▪ Depression ▪ Ellis-van Creveld syndrome ▪ Conduct disorder ▪ Dermatitis ▪ Emery-Dreifuss muscular dystrophy ▪ Cone-rod dystrophy ▪ Desmosterolosis ▪ Emphysema ▪ Congenital adrenal hyperplasia ▪ Diabetes ▪ Encephalopathy ▪ Congenital cataract ▪ Diamond-Blackfan anemia ▪ Endometrial cancer ▪ Congenital contractual arachnodactyly ▪ Diaphyseal dysplasia ▪ Endometriosis ▪ Congenital disorder of glycosylation ▪ Diaphyseal medullary stenosis with malignant fibrous histiocytoma ▪ Endurance ▪ Congenital disorder of glycosylation type 1t ▪ Diarrhea with microvillus atrophy ▪ Enlarged parietal foramina ▪ Congenital dyserythropoietic anemia ▪ Diastrophic dysplasia ▪ Epidermolysis bullosa ▪ Congenital hypothyroidism ▪ Dicarboxylic aminoaciduria ▪ Epidermolysis bullosa dystrophica ▪ Congenital ichthyosiform erythroderma ▪ Digital clubbing ▪ Epidermolysis bullosa junctionalis with pyloric atresia ▪ Congenital lactase deficiency ▪ Dilated cardiomyopathy ▪ Epidermolysis bullosa simplex ▪ Congenital muscular dystrophy ▪ Disordered steroidogenesis due to cytochrome p450 oxidoreductase ▪ Epilepsy ▪ Congenital myasthenic syndrome ▪ Episodic memory ▪ Congenital sensory neuropathy with selective loss of small deficiency ▪ Essential thrombocythemia ▪ Disorders of intracellular cobalamin metabolism ▪ Estrogen resistance myelinated fibers ▪ Distal myopathy Markesbery-Griggs type ▪ Exfoliation syndrome ▪ Congenital stationary night blindness ▪ Distal renal tubular acidosis ▪ Factor V deficiency ▪ Corneal dystrophy ▪ Distal spinal muscular atrophy ▪ FADS haplotype ▪ Coronary artery calcification ▪ Donnai Barrow syndrome ▪ Familial adenomatous polyposis 1 ▪ Coronary artery disease ▪ Dopamine beta hydroxylase deficiency ▪ Corticosterone methyl oxidase type 2 deficiency ▪ Cortisone reductase deficiency 1 www.alpsmedical.com
Tertiary analysis (669 traits) includes: ▪ Fundus albipunctatus ▪ Hereditary breast and ovarian cancer syndrome ▪ Galactosyl ceramide beta-galactosidase deficiency ▪ Hereditary cancer-predisposing syndrome ▪ Familial amyloid nephropathy with urticaria AND deafness ▪ Gallbladder cancer ▪ Hereditary diffuse gastric cancer ▪ Familial atrial fibrillation ▪ Gamma-aminobutyric acid transaminase deficiency ▪ Hereditary essential tremor ▪ Familial atypical mycobacteriosis ▪ Gastric cancer ▪ Hereditary factor II deficiency disease ▪ Familial cancer of breast ▪ Gastrointestinal stromal tumor ▪ Hereditary liability to pressure palsies ▪ Familial candidiasis ▪ Generalized epilepsy with febrile seizures plus ▪ Hereditary myopathy with early respiratory failure ▪ Familial cold autoinflammatory syndrome ▪ Gestational diabetes ▪ Hereditary pancreatitis ▪ Familial colorectal cancer ▪ Glanzmann thrombasthenia ▪ Hereditary pyropoikilocytosis ▪ Familial dysautonomia ▪ Glaucoma ▪ Hereditary sensory and autonomic neuropathy type II ▪ Familial erythrocytosis ▪ Glioma ▪ Hereditary sensory and autonomic neuropathy type IIA ▪ Familial exudative vitreoretinopathy ▪ Glucose transporter type 1 deficiency syndrome ▪ Hermansky-Pudlak syndrome ▪ Familial hemophagocytic lymphohistiocytosis ▪ Glutaric acidemia ▪ Herpes ▪ Familial high density lipoprotein deficiency ▪ Glutaric aciduria ▪ Heterotaxy syndrome ▪ Familial hyperaldosteronism ▪ Glycogen storage disease ▪ High density lipoprotein cholesterol level quantitative trait locus 9 ▪ Familial hypercholesterolemia ▪ Gonadotropin-independent familial sexual precocity ▪ High density lipoprotein cholesterol level quantitative trait locus 10 ▪ Familial hypobetalipoproteinemia ▪ Gorlin syndrome ▪ High density lipoprotein cholesterol level quantitative trait locus 12 ▪ Familial Mediterranean Fever ▪ Gout ▪ Hirschsprung disease ▪ Familial partial lipodystrophy ▪ Graves’ disease ▪ Histidinemia ▪ Familial renal hypouricemia ▪ Greenberg dysplasia ▪ Histiocytosis-lymphadenopathy plus syndrome ▪ Familial restrictive cardiomyopathy ▪ Grieg cephalopolysyndactyly syndrome ▪ HIV ▪ Familial visceral amyloidosis ▪ GTP cyclohydrolase I deficiency ▪ HLA ▪ Fanconi anemia ▪ Hair color ▪ Hodgkin lymphoma ▪ Farber’s lipogranulomatosis ▪ Hair morphology 1 ▪ Holoprosencephaly ▪ Fasting plasma glucose level quantitative trait locus 5 ▪ Handedness ▪ Holt-Oram syndrome ▪ Fatal infantile cardioencephalomyopathy ▪ Haplogroups ▪ Homocystinuria ▪ Fetal hemoglobin quantitative trait locus 1 ▪ Hashimoto’s thyroiditis ▪ Huntington disease ▪ Fetal hemoglobin quantitative trait locus 2 ▪ HDL cholesterol ▪ Hutchinson-Gilford syndrome ▪ Fibrochondrogenesis ▪ Heart diseases ▪ Hyperaldosteronism ▪ Fibromyalgia ▪ Hemochromatosis ▪ Hypercholanemia ▪ Fluorouracil ▪ Hemoglobin ▪ Hypercholesterolemia ▪ Foveal hypoplasia and presenile cataract syndrome ▪ Hemolytic anemia ▪ Hyperekplexia ▪ Freckling ▪ Hepatic lipase deficiency ▪ Hyperglycinuria ▪ Frontotemporal dementia ▪ Hepatic venoocclusive disease with immunodeficiency ▪ Hypergonadotropic hypogonadism ▪ Frontotemporal lobar degeneration with ubiquitin-positive ▪ Hepatitis B virus ▪ Hyperinsulinism ▪ Hepatitis C ▪ Hyperlipidemia inclusions ▪ Hereditary angioedema ▪ Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome ▪ Fructose-biphosphatase deficiency ▪ Fuchs’ dystrophy ▪ Fucosidosis www.alpsmedical.com
Tertiary analysis (669 traits) includes: ▪ KCNQ2-related disorders ▪ Maple syrup urine disease ▪ Keratitis ▪ Marshall syndrome ▪ Hyperphosphatasemia with bone disease ▪ Keutel syndrome ▪ MASP2 deficiency ▪ Hyperthyroidism ▪ Kidney stones ▪ Maturity-onset diabetes of the young ▪ Hypertriglyceridemia ▪ LDL cholesterol ▪ Meckel-Gruber syndrome ▪ Hypocalcemia ▪ Leprosy ▪ Megaloblastic anemia ▪ Hypocalciuric hypercalcemia ▪ Lethal tight skin contracture syndrome ▪ Meier-Gorlin syndrome ▪ Hypoglycemia with deficiency of glycogen synthetase in the liver ▪ Leukemia ▪ Memory ▪ Hypogonadism with anosmia ▪ Leukocyte adhesion deficiency ▪ Meniere’s disease ▪ Hypohidrotic ectodermal dysplasia ▪ Leukocyte adhesion deficiency type 1 ▪ Meningioma ▪ Hypomagnesemia 1 ▪ Leukoencephalopathy with vanishing white matter ▪ Menopause ▪ Hypophosphatasia ▪ Levy-Hollister syndrome ▪ Mental health ▪ Hypophosphatemic rickets ▪ Leydig cell agenesis ▪ Mesangiocapillary glomerulonephritis ▪ Idiopathic fibrosing alveolitis ▪ Li-Fraumeni syndrome ▪ Metabolic syndrome ▪ Immunodeficiency with Hyper-IgM ▪ Lig4 syndrome ▪ Metachromatic leukodystrophy ▪ Infantile cortical hyperostosis ▪ Limb-Girdle muscular dystrophy ▪ Metaphyseal anadysplasia ▪ Infantile hypercalcemia ▪ Lip and oral cavity carcinoma ▪ Microcephalic osteodysplastic primordial dwarfism ▪ Inflammatory bowel disease ▪ Lipoatrophy with diabetes ▪ Microcephaly ▪ Influenza ▪ Lissencephaly ▪ Microcytic anemia ▪ Insomnia ▪ Localized AR hypotrichosis ▪ Micronutrient metabolism ▪ Insulin resistance ▪ Loeys-Dietz syndrome ▪ Microtia ▪ Insulin-like growth factor I deficiency ▪ Long QT syndrome ▪ Migraines ▪ Insulin-resistant diabetes mellitus AND acanthosis nigricans ▪ Longevity ▪ Mitochondrial complex I deficiency ▪ Intellectual disability ▪ Lumbar disc disease ▪ Mitochondrial DNA depletion syndrome ▪ Intelligence ▪ Lumbar disc herniation ▪ Mitochondrial haplogroup ▪ Interleukin 1 receptor antagonist deficiency ▪ Lung cancer ▪ Monogenic non-syndromic obesity ▪ Intermediate maple syrup urine disease type 2 ▪ Lupus ▪ Mosaic variegated aneuploidy syndrome ▪ Intracranial Aneurysm ▪ Lyme disease ▪ MTHFR deficiency ▪ IRAK4 deficiency ▪ Lymphedema ▪ Mucopolysaccharidosis type VI ▪ Ischemic stroke ▪ Lymphoma ▪ Mucopolysaccharidosis type VII ▪ Isolated coronal synostosis ▪ Lynch syndrome ▪ Multicentric Osteolysis-Nodulosis-Arthropathy (MONA) spectrum disorders ▪ Isolated GnRH deficiency ▪ Macular degeneration ▪ Multiple endocrine neoplasia ▪ Isolated non-syndromic congenital heart disease ▪ Malaria ▪ Multiple epiphyseal dysplasia ▪ Jackson-Weiss syndrome ▪ Male infertility ▪ Multiple myeloma ▪ Jarcho-Levin syndrome ▪ Malignant melanoma ▪ Multiple sclerosis ▪ Jervell and Lange-Nielsen syndrome ▪ Mandibuloacral dysplasia with type A lipodystrophy ▪ Muscular dystrophy ▪ Joubert syndrome ▪ Mannose-binding protein deficiency ▪ Musical aptitude ▪ Juvenile polyposis ▪ Kawasaki disease www.alpsmedical.com
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