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xl Ahuja KD, Ball MJ, Br J Nutr, 2006, August; 96(2): 239- 42 xli Yoshioka M, Imanaga M, Ueyama H, Yamane M, Kubo Y, Boivin A, St Amand J, Tanaka H, Kiyonaga A, Br J Nutr, 2004 Jun; 91(6):991-5 xlii Saleem M, Cancer Lett. 2008 Nov 28, 285(2):109-15 Appendix VI: Dr. Suphala Gupta & Dr. Neha Dhar 1. Aneiros A, Garateix A (2004) Bioactive peptides from marine sources: pharmacological properties and isolation procedures. Journal of Chromatography B 803 (1):41-53. doi:https://doi.org/10.1016/j.jchromb.2003.11.005 2. Anupama, Ravindra P (2000) Value-added food:: Sin- gle cell protein. Biotechnology Advances 18 (6):459-479. doi:https://doi.org/10.1016/S0734-9750(00)00045-8 3. Bianchi CN, Morri C (2000) Marine Biodiversity of the Mediterranean Sea: Situation, Problems and Prospects for Future Research. Marine Pollution Bulletin 40 (5):367-376. doi:https://doi.org/10.1016/S0025-326X(00)00027-8 4. Bowen BW, Rocha LA, Toonen RJ, Karl SA (2013) The origins of tropical marine biodiversity. Trends in Ecolo- gy & Evolution 28 (6):359-366. doi:https://doi.org/10.1016/j.tree.2013.01.018 5. Chung C-C, Hwang S-PL, Chang J (2003) Identifica- tion of a High-Affinity Phosphate Transporter Gene in a Prasinophyte Alga, <i>Tetraselmis chui</i>, and Its Expres- sion under Nutrient Limitation. Applied and Environmental 235

Microbiology 69 (2):754-759. doi:doi:10.1128/AEM.69.2.754-759.2003 6. Ekberg J, Craik DJ, Adams DJ (2008) Conotoxin mod- ulation of voltage-gated sodium channels. The International Journal of Biochemistry & Cell Biology 40 (11):2363-2368. doi:https://doi.org/10.1016/j.biocel.2007.08.017 7. Giordano D, Costantini M, Coppola D, Lauritano C, Núñez Pons L, Ruocco N, di Prisco G, Ianora A, Verde C (2018) Chapter Five - Biotechnological Applications of Bio- active Peptides From Marine Sources. In: Poole RK (ed) Ad- vances in Microbial Physiology, vol 73. Academic Press, pp 171-220. doi:https://doi.org/10.1016/bs.ampbs.2018.05.002 8. Gogineni V, Hamann MT (2018) Marine natural prod- uct peptides with therapeutic potential: Chemistry, biosyn- thesis, and pharmacology. Biochimica et Biophysica Acta (BBA) - General Subjects 1862 (1):81-196. doi:https://doi.org/10.1016/j.bbagen.2017.08.014 9. Gong F, Sheng J, Chi Z, Li J (2007) Inulinase produc- tion by a marine yeast Pichia guilliermondii and inulin hy- drolysis by the crude inulinase. Journal of Industrial Micro- biology and Biotechnology 34 (3):179-185. doi:10.1007/s10295-006-0184-2 10. Jo C, Khan FF, Khan MI, Iqbal J (2017) Marine bioac- tive peptides: Types, structures, and physiological functions. Food Reviews International 33 (1):44-61. doi:10.1080/87559129.2015.1137311 236

11. Kurita K (2006) Chitin and Chitosan: Functional Bi- opolymers from Marine Crustaceans. Marine Biotechnology 8 (3):203. doi:10.1007/s10126-005-0097-5 12. Lebbe EKM, Peigneur S, Wijesekara I, Tytgat J (2014) Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview. Marine Drugs 12 (5):2970-3004 13. Li X, Tae H-S, Chu Y, Jiang T, Adams DJ, Yu R (2021) Medicinal chemistry, pharmacology, and therapeutic poten- tial of α-conotoxins antagonizing the α9α10 nicotinic acetyl- choline receptor. Pharmacology & Therapeutics 222:107792. doi:https://doi.org/10.1016/j.pharmthera.2020.107792 14. Lin H-Y, Shih C-Y, Liu H-C, Chang J, Chen Y-L, Chen Y-R, Lin H-T, Chang Y-Y, Hsu C-H, Lin H-J (2013) Identi- fication and Characterization of an Extracellular Alkaline Phosphatase in the Marine Diatom Phaeodactylum tricornu- tum. Marine Biotechnology 15 (4):425-436. doi:10.1007/s10126-013-9494-3 15. Mori TA (2017) Marine OMEGA-3 fatty acids in the prevention of cardiovascular disease. Fitoterapia 123:51-58. doi:10.1016/j.fitote.2017.09.015 16. Nakagawa T, Tagawa T (2000) Ultrastructural study of direct bone formation induced by BMPs-collagen complex implanted into an ectopic site. Oral Diseases 6 (3):172-179. doi:https://doi.org/10.1111/j.1601-0825.2000.tb00329.x 17. Ngo D-H, Vo T-S, Ngo D-N, Wijesekara I, Kim S-K (2012) Biological activities and potential health benefits of bioactive peptides derived from marine organisms. Interna- 237

tional Journal of Biological Macromolecules 51 (4):378-383. doi:https://doi.org/10.1016/j.ijbiomac.2012.06.001 18. Nwe N, Furuike T, Tamura H (2014) Chapter One - Iso- lation and Characterization of Chitin and Chitosan from Ma- rine Origin. In: Kim S-K (ed) Advances in Food and Nutri- tion Research, vol 72. Academic Press, pp 1-15. doi:https://doi.org/10.1016/B978-0-12-800269-8.00001-4 19. Rick TC, Henkes GA, Lowery DL, Colman SM, Culle- ton BJ (2017) Marine radiocarbon reservoir corrections (ΔR) for Chesapeake Bay and the Middle Atlantic Coast of North America. Quaternary Research 77 (1):205-210. doi:10.1016/j.yqres.2011.11.002 20. Robinson SD, Norton RS (2014) Conotoxin Gene Super- families. Marine Drugs 12 (12):6058-6101 21. Rosellini E, Madeddu D, Barbani N, Frati C, Graiani G, Falco A, Lagrasta C, Quaini F, Cascone MG (2020) Devel- opment of Biomimetic Alginate/Gelatin/Elastin Sponges with Recognition Properties toward Bioactive Peptides for Cardi- ac Tissue Engineering. Biomimetics 5 (4):67 22. Schmitz C, González Auza L, Koberidze D, Rasche S, Fischer R, Bortesi L (2019) Conversion of Chitin to Defined Chitosan Oligomers: Current Status and Future Prospects. Marine Drugs 17 (8):452 23. Shahidi F (2007) 16 - Chitin and chitosan from marine by-products. In: Shahidi F (ed) Maximising the Value of Ma- rine By-Products. Woodhead Publishing, pp 340-373. doi:https://doi.org/10.1533/9781845692087.2.340 238

24. Wang X, Yu H, Xing R, Li P (2017) Characterization, Preparation, and Purification of Marine Bioactive Peptides. BioMed Research International 2017:9746720. doi:10.1155/2017/9746720 Appendix VII: Dr. Swati & Dr. Jyotsna Girola: 1. Aneiros A, Garateix A (2004) Bioactive peptides from marine sources: pharmacological properties and isolation procedures. Journal of Chromatography B 803 (1):41-53. doi:https://doi.org/10.1016/j.jchromb.2003.11.005 2. Anupama, Ravindra P (2000) Value-added food:: Single cell protein. Biotechnology Advances 18 (6):459-479. doi:https://doi.org/10.1016/S0734-9750(00)00045-8 3. Bianchi CN, Morri C (2000) Marine Biodiversity of the Mediterranean Sea: Situation, Problems and Prospects for Future Research. Marine Pollution Bulletin 40 (5):367-376. doi:https://doi.org/10.1016/S0025-326X(00)00027-8 4. Bowen BW, Rocha LA, Toonen RJ, Karl SA (2013) The origins of tropical marine biodiversity. Trends in Ecology & Evolution 28 (6):359-366. doi:https://doi.org/10.1016/j.tree.2013.01.018 5. Chung C-C, Hwang S-PL, Chang J (2003) Identification of a High-Affinity Phosphate Transporter Gene in a Prasinophyte Alga, <i>Tetraselmis chui</i>, and Its Expression under Nutrient Limitation. Applied and Environmental Microbiology 69 (2):754-759. doi:doi:10.1128/AEM.69.2.754-759.2003 239

6. Ekberg J, Craik DJ, Adams DJ (2008) Conotoxin modulation of voltage-gated sodium channels. The International Journal of Biochemistry & Cell Biology 40 (11):2363-2368. doi:https://doi.org/10.1016/j.biocel.2007.08.017 7. Giordano D, Costantini M, Coppola D, Lauritano C, Núñez Pons L, Ruocco N, di Prisco G, Ianora A, Verde C (2018) Chapter Five - Biotechnological Applications of Bioactive Peptides From Marine Sources. In: Poole RK (ed) Advances in Microbial Physiology, vol 73. Academic Press, pp 171-220. doi:https://doi.org/10.1016/bs.ampbs.2018.05.002 8. Gogineni V, Hamann MT (2018) Marine natural product peptides with therapeutic potential: Chemistry, biosynthesis, and pharmacology. Biochimica et Biophysica Acta (BBA) - General Subjects 1862 (1):81-196. doi:https://doi.org/10.1016/j.bbagen.2017.08.014 9. Gong F, Sheng J, Chi Z, Li J (2007) Inulinase production by a marine yeast Pichia guilliermondii and inulin hydrolysis by the crude inulinase. Journal of Industrial Microbiology and Biotechnology 34 (3):179-185. doi:10.1007/s10295-006-0184-2 10. Jo C, Khan FF, Khan MI, Iqbal J (2017) Marine bioactive peptides: Types, structures, and physiological functions. Food Reviews International 33 (1):44-61. doi:10.1080/87559129.2015.1137311 240

11. Kurita K (2006) Chitin and Chitosan: Functional Biopolymers from Marine Crustaceans. Marine Biotechnology 8 (3):203. doi:10.1007/s10126-005-0097-5 12. Lebbe EKM, Peigneur S, Wijesekara I, Tytgat J (2014) Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview. Marine Drugs 12 (5):2970-3004 13. Li X, Tae H-S, Chu Y, Jiang T, Adams DJ, Yu R (2021) Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor. Pharmacology & Therapeutics 222:107792. doi:https://doi.org/10.1016/j.pharmthera.2020.107792 14. Lin H-Y, Shih C-Y, Liu H-C, Chang J, Chen Y-L, Chen Y-R, Lin H-T, Chang Y-Y, Hsu C-H, Lin H-J (2013) Identification and Characterization of an Extracellular Alkaline Phosphatase in the Marine Diatom Phaeodactylum tricornutum. Marine Biotechnology 15 (4):425-436. doi:10.1007/s10126-013-9494-3 15. Mori TA (2017) Marine OMEGA-3 fatty acids in the prevention of cardiovascular disease. Fitoterapia 123:51-58. doi:10.1016/j.fitote.2017.09.015 16. Nakagawa T, Tagawa T (2000) Ultrastructural study of direct bone formation induced by BMPs-collagen complex implanted into an ectopic site. Oral Diseases 6 (3):172-179. doi:https://doi.org/10.1111/j.1601-0825.2000.tb00329.x 241

17. Ngo D-H, Vo T-S, Ngo D-N, Wijesekara I, Kim S-K (2012) Biological activities and potential health benefits of bioactive peptides derived from marine organisms. International Journal of Biological Macromolecules 51 (4):378-383. doi:https://doi.org/10.1016/j.ijbiomac.2012.06.001 18. Nwe N, Furuike T, Tamura H (2014) Chapter One - Isolation and Characterization of Chitin and Chitosan from Marine Origin. In: Kim S-K (ed) Advances in Food and Nutrition Research, vol 72. Academic Press, pp 1-15. doi:https://doi.org/10.1016/B978-0-12-800269-8.00001-4 19. Rick TC, Henkes GA, Lowery DL, Colman SM, Culleton BJ (2017) Marine radiocarbon reservoir corrections (ΔR) for Chesapeake Bay and the Middle Atlantic Coast of North America. Quaternary Research 77 (1):205-210. doi:10.1016/j.yqres.2011.11.002 20. Robinson SD, Norton RS (2014) Conotoxin Gene Superfamilies. Marine Drugs 12 (12):6058-6101 21. Rosellini E, Madeddu D, Barbani N, Frati C, Graiani G, Falco A, Lagrasta C, Quaini F, Cascone MG (2020) Development of Biomimetic Alginate/Gelatin/Elastin Sponges with Recognition Properties toward Bioactive Peptides for Cardiac Tissue Engineering. Biomimetics 5 (4):67 22. Schmitz C, González Auza L, Koberidze D, Rasche S, Fischer R, Bortesi L (2019) Conversion of Chitin to 242

Defined Chitosan Oligomers: Current Status and Future Prospects. Marine Drugs 17 (8):452 23. Shahidi F (2007) 16 - Chitin and chitosan from marine by-products. In: Shahidi F (ed) Maximising the Value of Marine By-Products. Woodhead Publishing, pp 340-373. doi:https://doi.org/10.1533/9781845692087.2.340 24. Wang X, Yu H, Xing R, Li P (2017) Characterization, Preparation, and Purification of Marine Bioactive Peptides. BioMed Research International 2017:9746720. doi:10.1155/2017/9746720 243

Science Citation: Surinder Kitchlu 244

Authors INSERIRE COLLAGE DEGLI AUTORI SIMILE A QUESTO 245

Dr. Anna Maria Clement began her career as a natural health advocate in her early adult years, after her family had embraced a plant-based diet. Her interest in learning from the global natural health movement burgeoned into a part time job as she was academically learning about the foundation of anatomy, biochemistry, and health. At the same time, she founded Scandinavia’s very first “Living Foods” organiza- tion. As a member of the Natural Health Care Coalition of Sweden, a government supported effort in unifying the field of complementary healthcare, she was able to help countless people on the path to health. Anna lectures extensively worldwide, including the Kaunas University of Lithuania, Nobel Hall in Stockholm, Sweden, University of Manchester, Exeter University, U.K., and an endless list of others. Dr. Brian Clement began his journey to embrace a healthier way of life at an early age of 20. For half a century, Clement has expanded his knowledge and competency by stretching the boundaries, borders and limitations of his realm. Clement joined the HHI team at their Boston facility in 1975. Within a year he was representing the institute via lectures, seminars, conferences, and TV and radio interviews. In addition, he was published in much of the print media throughout the US and Europe. With his wife and Co Director Anna Maria Clement, they have worked tirelessly to build the Institute’s outreach, advance technologies, and scope of offerings. This sprawling Institute rests on sixty tropical acres. At the turn of the twenty-first century the Institute received the notable award as the world’s foremost healing center. Dr. Anamika Khajuria is a retired scientist from Indian In- stitute of Integrative Medicine,CSIR Jammu, & has done her Ph.D in Immunology. She is an immunologist and was in- volved in the development of immunomodulators keeping the 246

mandate of CSIR Institute, & IIIM Jammu, where sincere ef- forts are made to develop natural products as drug candidates for treatment of cancerous & infectious diseases. Dr. Ana- mika has received the best paper award in the Oxford Inter- national Conference on the Science of Botanicals in 2007. She has guided more than 60 Phd and postgraduate students in immunology techniques for fulfillment of their PG cours- es. As a Principal Investigator, her scientific team has en- hanced the potential of the Pharma & Biotech Industry. Dr. Sushma Koul has more than thirty-eight years’ experi- ence in development of propagation protocols of high alti- tude medicinal and aromatic plants with their implication for conservation. Production of bioactive metabolites in vitro. Development of bioreactor system for plant cell &amp; or- gan cultures Plant fermentation for production of plant bioac- tive and value additions through biotransformation utilizing plant cell suspension culture system. Adaptive Biology and plant Physiology. She has published 40 papers and has 3 pa- tents. Dr. Anpurna Kaul works as scientist in Pharmacology Di- vision of Indian Institute of Integrative Medicine (CSIP), Jammu, India. She has completed her Ph.D in 1996 from University of Jammu. Her field of research is immune phar- macology. Dr. Kaul has 35 research publications in national and international journals, 12 patents and also presented sev- eral research papers in various symposia/conferences. She has screened more than 4000 plant extracts/fractions and pure compounds on immune system by in vivo and in vitro methods. She has also actively participated in Indo- Malaysian research project as member and visited Malaysia in 2007 to attend Women’s Health and Asian Traditional Medicine Conference. 247

Dr. Sarojini Johri is a retired Principal Technical Officer, Department of Microbial Biotechnology, she worked for 33 years at Indian Institute of Integrative Medicine (CSIR) Jammu. Dr. Johri has published 35 high impact pa- pers and is member of following scientific committees: In- dian Science Congress Association, Panjab University Alumni, Society of Biological chemist of India, Association of microbiologists of India and Biotech Research society of India. Dr. Surjit Singh is superannuated as Principal technical of- ficer, a post equivalent to assist director of govt of India. He is also designated Associate Prof. in AcSIR, an academic wing of CSIR for PhD programs. He published around 100 scientific publications in national and international journals. He is contributor of 13 lndian and European patents and has written 8 book chapters as well as edited five books of scien- tific publications. Dr. Surinder Kitchlu has a MSc PhD in botanical sciences, with research experience of 35 years in laboratory to land re- lated projects. He has 30 publications in impact factor jour- nals. He has keen interest in essential oil bearing plants & is an expert in Ladakh flora. Dr. Rekha Sapru Dhar specialises in the Molecular charac- terization of the germplasm of aromatic and medicinal plants. Molecular cloning and functional validation of genes in- volved in the biosyhthetic pathways of Withania somnifera; Picrorrhiza kurroa and Pelargonium graveolens. She has 36 publications and 1 patent. Dr. Suphla Gupta’s core research areas includes Plant Mo- lecular Biology, DNA Fingerprinting and Barcoding, Tissue 248

Culture and Plant Proteomics. These are the approaches be- ing utilized in her Lab to understand secondary metabolite biosynthesis of medicinal plants, development of tissue cul- ture protocols for rare and endangered plants and plant bar- coding and fingerprinting for Intellectual property rights pro- tection. Her Lab has also chemically and genetically charac- terized and catalogued more than 250 Ginger germplasm from North western Himalayas and DNA barcoded medicinal plants collected from Cold desert areas of Leh and Ladakh region of India. She has published more than 40 peer re- viewed research papers, delivered eleven invited Lectures and attended over fifty International &amp; National Confer- ences. Dr. Asha Chaubey is presently working as Senior Principal Scientist and Head of Fermentation and Microbial Biotech- nology Division. She has been working in the area of fermen- tation technology for exploration and exploitation of micro- organisms for the production of bioactives and novel en- zymes for more than 18 years. She obtained Ph.D. degree from LLRM Medical college, Meerut in collaboration with National Physical Laboratory in the field of biosensors for diagnostics. During the doctoral research; she has significant- ly contributed towards the development of biosensors for health care and generated good quality publications and patents. Dr. Vidushi Mahajan completed her B. Tech &amp; M. Tech with distinction from Amity Institute of Biotechnology, Amity University Noida, U.P, India followed by Ph.D in Plant Biotechnology from Council of Scientific and Industri- al Research (CSIR)-Indian Institute of Integrative Medicine (IIIM), Jammu, India Dr. Mahajan has published her research findings in about 23 peer-reviewed International Journals. 249

She has presented her research finds at national as well as in- ternational forums in series of International and National Conferences during her research carrier. Dr. Vidushi Abrol is a Researcher Associate at CSIR-Indian Institutute of Integrative Medicine. She got her Ph.D at Shri Mata Vaishno Devi University, Katra. Her career planning consists of effective implementation of given task and re- sponsibilities. Her thesis research interest was on chemical mutagenesis and isolation of secondary metabolites fromim- portant fungi. Her current post-doctoral studies focusing on the microbial transformation studies of natural drugs, its im- portance in correlating them with the corresponding metabo- lism (biotransformation) in biological system and in the structural modification of complex drug molecules, which are difficult to obtain synthetically. Dr. Swati K. won Women’s Leadership award for 2022, for being a breakthrough researcher & an editor. She was select- ed by African Union to be one of the 100 women who makes a difference in Africa. She has provided valuable insights in- to global and regional political and economic influences. She is also a published author of four books and 10 professional scientific papers, an editor, a columnist with fifteen years of experience, specializing in foreign & science policy review & analysis. She is a cancer immunology research strategist with two decades of experience, specializing in organic syn- thesis, analytical elucidation of molecular structures, drug discovery research development using two new novel mole- cules on breast, lung, pancreas, colon, & prostate cancers. 250