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xxxviii Chou CC, Wu YC, Wang YF, Chou MJ, Kuo SJ, Chen DR, Oncol Rep. 2009 Mar, 21(3): 665-71 xxxix Ito K, Nakazato T, Yamato K, Miyakawa Y, Yamada T, Hozumi N, Segawa K, Ikeda Y, Kizaki M; Cancer Res 2004 Feb 1, 64(3):1071-8 xl Ahuja KD, Ball MJ, Br J Nutr, 2006, August; 96(2): 239- 42 xli Yoshioka M, Imanaga M, Ueyama H, Yamane M, Kubo Y, Boivin A, St Amand J, Tanaka H, Kiyonaga A, Br J Nutr, 2004 Jun; 91(6):991-5 xlii Saleem M, Cancer Lett. 2008 Nov 28, 285(2):109-15 Appendix VI: Dr. Suphala Gupta & Dr. Neha Dhar 1. Aneiros A, Garateix A (2004) Bioactive peptides from marine sources: pharmacological properties and isolation procedures. Journal of Chromatography B 803 (1):41-53. doi:https://doi.org/10.1016/j.jchromb.2003.11.005 2. Anupama, Ravindra P (2000) Value-added food:: Sin- gle cell protein. Biotechnology Advances 18 (6):459-479. doi:https://doi.org/10.1016/S0734-9750(00)00045-8 3. Bianchi CN, Morri C (2000) Marine Biodiversity of the Mediterranean Sea: Situation, Problems and Prospects for Future Research. Marine Pollution Bulletin 40 (5):367-376. doi:https://doi.org/10.1016/S0025-326X(00)00027-8 4. Bowen BW, Rocha LA, Toonen RJ, Karl SA (2013) The origins of tropical marine biodiversity. Trends in Ecolo- gy & Evolution 28 (6):359-366. doi:https://doi.org/10.1016/j.tree.2013.01.018 245

5. Chung C-C, Hwang S-PL, Chang J (2003) Identifica- tion of a High-Affinity Phosphate Transporter Gene in a Prasinophyte Alga, <i>Tetraselmis chui</i>, and Its Expres- sion under Nutrient Limitation. Applied and Environmental Microbiology 69 (2):754-759. doi:doi:10.1128/AEM.69.2.754-759.2003 6. Ekberg J, Craik DJ, Adams DJ (2008) Conotoxin mod- ulation of voltage-gated sodium channels. The International Journal of Biochemistry & Cell Biology 40 (11):2363-2368. doi:https://doi.org/10.1016/j.biocel.2007.08.017 7. Giordano D, Costantini M, Coppola D, Lauritano C, Núñez Pons L, Ruocco N, di Prisco G, Ianora A, Verde C (2018) Chapter Five - Biotechnological Applications of Bio- active Peptides From Marine Sources. In: Poole RK (ed) Ad- vances in Microbial Physiology, vol 73. Academic Press, pp 171-220. doi:https://doi.org/10.1016/bs.ampbs.2018.05.002 8. Gogineni V, Hamann MT (2018) Marine natural prod- uct peptides with therapeutic potential: Chemistry, biosyn- thesis, and pharmacology. Biochimica et Biophysica Acta (BBA) - General Subjects 1862 (1):81-196. doi:https://doi.org/10.1016/j.bbagen.2017.08.014 9. Gong F, Sheng J, Chi Z, Li J (2007) Inulinase produc- tion by a marine yeast Pichia guilliermondii and inulin hy- drolysis by the crude inulinase. Journal of Industrial Micro- biology and Biotechnology 34 (3):179-185. doi:10.1007/s10295-006-0184-2 10. Jo C, Khan FF, Khan MI, Iqbal J (2017) Marine bioac- tive peptides: Types, structures, and physiological functions. 246

Food Reviews International 33 (1):44-61. doi:10.1080/87559129.2015.1137311 11. Kurita K (2006) Chitin and Chitosan: Functional Bi- opolymers from Marine Crustaceans. Marine Biotechnology 8 (3):203. doi:10.1007/s10126-005-0097-5 12. Lebbe EKM, Peigneur S, Wijesekara I, Tytgat J (2014) Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview. Marine Drugs 12 (5):2970-3004 13. Li X, Tae H-S, Chu Y, Jiang T, Adams DJ, Yu R (2021) Medicinal chemistry, pharmacology, and therapeutic poten- tial of α-conotoxins antagonizing the α9α10 nicotinic acetyl- choline receptor. Pharmacology & Therapeutics 222:107792. doi:https://doi.org/10.1016/j.pharmthera.2020.107792 14. Lin H-Y, Shih C-Y, Liu H-C, Chang J, Chen Y-L, Chen Y-R, Lin H-T, Chang Y-Y, Hsu C-H, Lin H-J (2013) Identi- fication and Characterization of an Extracellular Alkaline Phosphatase in the Marine Diatom Phaeodactylum tricornu- tum. Marine Biotechnology 15 (4):425-436. doi:10.1007/s10126-013-9494-3 15. Mori TA (2017) Marine OMEGA-3 fatty acids in the prevention of cardiovascular disease. Fitoterapia 123:51-58. doi:10.1016/j.fitote.2017.09.015 16. Nakagawa T, Tagawa T (2000) Ultrastructural study of direct bone formation induced by BMPs-collagen complex implanted into an ectopic site. Oral Diseases 6 (3):172-179. doi:https://doi.org/10.1111/j.1601-0825.2000.tb00329.x 247

17. Ngo D-H, Vo T-S, Ngo D-N, Wijesekara I, Kim S-K (2012) Biological activities and potential health benefits of bioactive peptides derived from marine organisms. Interna- tional Journal of Biological Macromolecules 51 (4):378-383. doi:https://doi.org/10.1016/j.ijbiomac.2012.06.001 18. Nwe N, Furuike T, Tamura H (2014) Chapter One - Iso- lation and Characterization of Chitin and Chitosan from Ma- rine Origin. In: Kim S-K (ed) Advances in Food and Nutri- tion Research, vol 72. Academic Press, pp 1-15. doi:https://doi.org/10.1016/B978-0-12-800269-8.00001-4 19. Rick TC, Henkes GA, Lowery DL, Colman SM, Culle- ton BJ (2017) Marine radiocarbon reservoir corrections (ΔR) for Chesapeake Bay and the Middle Atlantic Coast of North America. Quaternary Research 77 (1):205-210. doi:10.1016/j.yqres.2011.11.002 20. Robinson SD, Norton RS (2014) Conotoxin Gene Super- families. Marine Drugs 12 (12):6058-6101 21. Rosellini E, Madeddu D, Barbani N, Frati C, Graiani G, Falco A, Lagrasta C, Quaini F, Cascone MG (2020) Devel- opment of Biomimetic Alginate/Gelatin/Elastin Sponges with Recognition Properties toward Bioactive Peptides for Cardi- ac Tissue Engineering. Biomimetics 5 (4):67 22. Schmitz C, González Auza L, Koberidze D, Rasche S, Fischer R, Bortesi L (2019) Conversion of Chitin to Defined Chitosan Oligomers: Current Status and Future Prospects. Marine Drugs 17 (8):452 23. Shahidi F (2007) 16 - Chitin and chitosan from marine by-products. In: Shahidi F (ed) Maximising the Value of Ma- 248

rine By-Products. Woodhead Publishing, pp 340-373. doi:https://doi.org/10.1533/9781845692087.2.340 24. Wang X, Yu H, Xing R, Li P (2017) Characterization, Preparation, and Purification of Marine Bioactive Peptides. BioMed Research International 2017:9746720. doi:10.1155/2017/9746720 Appendix VII: Dr. Swati & Dr. Jyotsna Girola: 1. Aneiros A, Garateix A (2004) Bioactive peptides from marine sources: pharmacological properties and isolation procedures. Journal of Chromatography B 803 (1):41-53. doi:https://doi.org/10.1016/j.jchromb.2003.11.005 2. Anupama, Ravindra P (2000) Value-added food:: Single cell protein. Biotechnology Advances 18 (6):459-479. doi:https://doi.org/10.1016/S0734-9750(00)00045-8 3. Bianchi CN, Morri C (2000) Marine Biodiversity of the Mediterranean Sea: Situation, Problems and Prospects for Future Research. Marine Pollution Bulletin 40 (5):367-376. doi:https://doi.org/10.1016/S0025-326X(00)00027-8 4. Bowen BW, Rocha LA, Toonen RJ, Karl SA (2013) The origins of tropical marine biodiversity. Trends in Ecology & Evolution 28 (6):359-366. doi:https://doi.org/10.1016/j.tree.2013.01.018 5. Chung C-C, Hwang S-PL, Chang J (2003) Identification of a High-Affinity Phosphate Transporter Gene in a Prasinophyte Alga, <i>Tetraselmis chui</i>, and Its Expression under Nutrient Limitation. Applied and 249

Environmental Microbiology 69 (2):754-759. doi:doi:10.1128/AEM.69.2.754-759.2003 6. Ekberg J, Craik DJ, Adams DJ (2008) Conotoxin modulation of voltage-gated sodium channels. The International Journal of Biochemistry & Cell Biology 40 (11):2363-2368. doi:https://doi.org/10.1016/j.biocel.2007.08.017 7. Giordano D, Costantini M, Coppola D, Lauritano C, Núñez Pons L, Ruocco N, di Prisco G, Ianora A, Verde C (2018) Chapter Five - Biotechnological Applications of Bioactive Peptides From Marine Sources. In: Poole RK (ed) Advances in Microbial Physiology, vol 73. Academic Press, pp 171-220. doi:https://doi.org/10.1016/bs.ampbs.2018.05.002 8. Gogineni V, Hamann MT (2018) Marine natural product peptides with therapeutic potential: Chemistry, biosynthesis, and pharmacology. Biochimica et Biophysica Acta (BBA) - General Subjects 1862 (1):81-196. doi:https://doi.org/10.1016/j.bbagen.2017.08.014 9. Gong F, Sheng J, Chi Z, Li J (2007) Inulinase production by a marine yeast Pichia guilliermondii and inulin hydrolysis by the crude inulinase. Journal of Industrial Microbiology and Biotechnology 34 (3):179-185. doi:10.1007/s10295-006-0184-2 10. Jo C, Khan FF, Khan MI, Iqbal J (2017) Marine bioactive peptides: Types, structures, and physiological 250

functions. Food Reviews International 33 (1):44-61. doi:10.1080/87559129.2015.1137311 11. Kurita K (2006) Chitin and Chitosan: Functional Biopolymers from Marine Crustaceans. Marine Biotechnology 8 (3):203. doi:10.1007/s10126-005-0097-5 12. Lebbe EKM, Peigneur S, Wijesekara I, Tytgat J (2014) Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview. Marine Drugs 12 (5):2970-3004 13. Li X, Tae H-S, Chu Y, Jiang T, Adams DJ, Yu R (2021) Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor. Pharmacology & Therapeutics 222:107792. doi:https://doi.org/10.1016/j.pharmthera.2020.107792 14. Lin H-Y, Shih C-Y, Liu H-C, Chang J, Chen Y-L, Chen Y-R, Lin H-T, Chang Y-Y, Hsu C-H, Lin H-J (2013) Identification and Characterization of an Extracellular Alkaline Phosphatase in the Marine Diatom Phaeodactylum tricornutum. Marine Biotechnology 15 (4):425-436. doi:10.1007/s10126-013-9494-3 15. Mori TA (2017) Marine OMEGA-3 fatty acids in the prevention of cardiovascular disease. Fitoterapia 123:51-58. doi:10.1016/j.fitote.2017.09.015 16. Nakagawa T, Tagawa T (2000) Ultrastructural study of direct bone formation induced by BMPs-collagen complex 251

implanted into an ectopic site. Oral Diseases 6 (3):172-179. doi:https://doi.org/10.1111/j.1601-0825.2000.tb00329.x 17. Ngo D-H, Vo T-S, Ngo D-N, Wijesekara I, Kim S-K (2012) Biological activities and potential health benefits of bioactive peptides derived from marine organisms. International Journal of Biological Macromolecules 51 (4):378-383. doi:https://doi.org/10.1016/j.ijbiomac.2012.06.001 18. Nwe N, Furuike T, Tamura H (2014) Chapter One - Isolation and Characterization of Chitin and Chitosan from Marine Origin. In: Kim S-K (ed) Advances in Food and Nutrition Research, vol 72. Academic Press, pp 1-15. doi:https://doi.org/10.1016/B978-0-12-800269-8.00001-4 19. Rick TC, Henkes GA, Lowery DL, Colman SM, Culleton BJ (2017) Marine radiocarbon reservoir corrections (ΔR) for Chesapeake Bay and the Middle Atlantic Coast of North America. Quaternary Research 77 (1):205-210. doi:10.1016/j.yqres.2011.11.002 20. Robinson SD, Norton RS (2014) Conotoxin Gene Superfamilies. Marine Drugs 12 (12):6058-6101 21. Rosellini E, Madeddu D, Barbani N, Frati C, Graiani G, Falco A, Lagrasta C, Quaini F, Cascone MG (2020) Development of Biomimetic Alginate/Gelatin/Elastin Sponges with Recognition Properties toward Bioactive Peptides for Cardiac Tissue Engineering. Biomimetics 5 (4):67 252

22. Schmitz C, González Auza L, Koberidze D, Rasche S, Fischer R, Bortesi L (2019) Conversion of Chitin to Defined Chitosan Oligomers: Current Status and Future Prospects. Marine Drugs 17 (8):452 23. Shahidi F (2007) 16 - Chitin and chitosan from marine by-products. In: Shahidi F (ed) Maximising the Value of Marine By-Products. Woodhead Publishing, pp 340-373. doi:https://doi.org/10.1533/9781845692087.2.340 24. Wang X, Yu H, Xing R, Li P (2017) Characterization, Preparation, and Purification of Marine Bioactive Peptides. BioMed Research International 2017:9746720. doi:10.1155/2017/9746720 253

Authors INSERIRE COLLAGE DEGLI AUTORI SIMILE A QUESTO 254

Dr. Anna Maria Clement began her career as a natural health advocate in her early adult years, after her family had embraced a plant-based diet. Her interest in learning from the global natural health movement burgeoned into a part time job as she was academically learning about the foundation of anatomy, biochemistry, and health. At the same time, she founded Scandinavia‘s very first ―Living Foods‖ organiza- tion. As a member of the Natural Health Care Coalition of Sweden, a government supported effort in unifying the field of complementary healthcare, she was able to help countless people on the path to health. Anna lectures extensively worldwide, including the Kaunas University of Lithuania, Nobel Hall in Stockholm, Sweden, University of Manchester, Exeter University, U.K., and an endless list of others. Dr. Brian Clement began his journey to embrace a healthier way of life at an early age of 20. For half a century, Clement has expanded his knowledge and competency by stretching the boundaries, borders and limitations of his realm. Clement joined the HHI team at their Boston facility in 1975. Within a year he was representing the institute via lectures, seminars, conferences, and TV and radio interviews. In addition, he was published in much of the print media throughout the US and Europe. With his wife and Co Director Anna Maria Clement, they have worked tirelessly to build the Institute‘s outreach, advance technologies, and scope of offerings. This sprawling Institute rests on sixty tropical acres. At the turn of the twenty-first century the Institute received the notable award as the world‘s foremost healing center. Dr. Anamika Khajuria is a retired scientist from Indian In- stitute of Integrative Medicine,CSIR Jammu, & has done her Ph.D in Immunology. She is an immunologist and was in- volved in the development of immunomodulators keeping the 255