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Solutions for Medical Point of Need TRAUMA RESPONSE BIOSENSORS TISSUE ENGINEERING FEBRUARY 2022 1

SOLUTIONS FOR MEDICAL POINT OF NEED: TRAUMA RESPONSE • BIOSENSORS • TISSUE ENGINEERING Our Smart Solutions & Devices • Bridging Battlefield Medical Gaps • Multifunctional “Smart” Formulations • MEDdefender • State-of-the-Art Delivery Adaptive Nanofibers 2

SOLUTIONS FOR MEDICAL POINT OF NEED: TRAUMA RESPONSE • BIOSENSORS • TISSUE ENGINEERING Multifunctional ‘Smart’ Formulations Nanofiber- Mimics the Extracellular Matrix Hydrogel Biocompatible, biodegradable Multifunctional Homogeneous formulation: Formulation hemostasis, wound & burns tissue healing, pain management, infection control Sensors & Mimics the Extracellular Matrix Triggers Biocompatible, biodegradable 3

SOLUTIONS FOR MEDICAL POINT OF NEED: TRAUMA RESPONSE • BIOSENSORS • TISSUE ENGINEERING Formulations Designed for Specific Roles of Care Role 1 Point of Need Dressing Improve survival rates and reduce wound infection Easy to use, rapid multifunctional injectable gel or nanofiber wound dressing that conforms to any wound shape: • Control hemostasis, burns, infection prevention tissue repair & healing Role 2-5 Secondary Care Dressing Enhanced burns injury management & infection control Multifunctional translucent dressings (especially advantageous for burns wounds): • Excellent adherence to the wound even in hard to dress contours • Semi-translucent for easy monitoring of the healing progress – reduces reinfection risk and no painful redressing • Accelerates the healing process & reduces scarring • Continuous controlled-release of analgesics provides comfort 4

SOLUTIONS FOR MEDICAL POINT OF NEED: TRAUMA RESPONSE • BIOSENSORS • TISSUE ENGINEERING Bioactive Nanofibrous- Hydrogel Dressing Compared to typical bandages, nanofiber-hydrogel dressings provide an exceptional environment to accelerate wound healing, improve tissue regeneration and prevent bacterial infection. for more rapid healing and reduced scarring. High Surface Area Ratio Semi-Translucent Protective Physical Barrier Enhanced hemostasis Improved Allows easy monitoring of the drug allocation - reduced amount healing process while reducing of polymer on tissue infection risk Semipermeable Conformability Oxygen & nutrient permeation Protects any shape of wound (air interchange) to help drive epithelization High Filtration & Liquid Absorption Efficiency Multi-functional Good absorbency of wound Precise control & quick release rate exudates of multiple therapeutics Biodegradability Biocompatibility • Non-toxic Scar-free tissue healing • Facilitates native tissue ingrowth without foreign body 5

SOLUTIONS FOR MEDICAL POINT OF NEED: TRAUMA RESPONSE • BIOSENSORS • TISSUE ENGINEERING Beta Prototype MEDdefenderTM All the concepts below will be determined from customerdiscussions during Alpha field trials and incorporated into Beta device Display Data Gathering Screen • Barcode scanner capability (pull / push warf- • System status ighter records) • Battery life • User • Record warfighter patient vital statistics • Video camera automatically records the instructions • Pre-loaded wound healing process: » MEDEVAC / trauma care team able to visual- training videos ize the wound before, during and after wound / visual aids dressing application • Patient vital » Improves wound healing reporting / statistics, statistics trend improving training of warfighters data (from oximeter) – • Capture wound data every time the device useful in PFC is used – i.e., how long was the device spray- scenarios ing the wound dressing, location, time, type of wound healing administered (improve wound healing reporting / statistics) Communication Capability Software • Connect device to local warfighter • Software updates communications (i.e., LAN/military unit via comms comms) – may eliminate need for USB port download 6