Microbioz India:April 2016:Preview

Dear friends first of all I would like to say you all deeply thanks for being here either as a our readers or supporter or our audience and how we can forget your great support for continuous launching of Microbioz India magazine. Dear friends Microbioz India going to launch anniversary edition of magazine featured with most interesting cover story for our audience entitled: “10 interesting facts of Zika” written and covered by Microbioz India editorial office. The cover story of this month will boost awareness and more as suggest few interesting on Zika virus updates and disease transmission. Dear friends apart from cover story magazine have an interesting featured article named 5 Bacterial mysteries uncovered: 2016 one of interesting uncovered over few bacterial mystery. Dear friends Microbioz India magazine from since last one year dedicated to build huge academic audiences and as we know our team members ,authors always tried to win heart of each audience for expel out quality cover story and maintain magazine contents in each edition and we ensure you all for doing same in near future. Collect lot of open scholarship position for pursuing higher education in the field of Microbiology, Biotechnology and Medical Sciences from reputed Universities of across the globe. In last phase of this magazine how we can forget to announce the names of winners of our March 2016 edition of crossword, Dear friends we request you to all for earlier submission of your answers and other feedbacks about magazine editions. Thanks Jeetendra Kumaar

08 Cover Story: 10 interesting facts on ZIKA 5 Bacterial mysteries Uncovered: 15 2016 Gut microbiota transfer affects 18 brain dysfunction and nerve fiber 18 26 insulation 28 Researcher finds new mechanism 19 21 responsible for cancer approach Bacterial feeding over fish gills, 20 type of new symbiosis: Recent study Tax over sugary drinks would 21 reduce annual health expenditure by $29 million as well as reduce obesity cases High fatty diet may trigger day 25 time sleeping 08 New molecular structure of 26 antibiotic for fighting with all types of bacterial strain 28 Great initiative takes by Tata trust Microbioz India: Scholarship 29 positions Microbioz India Crossword: April 37 2016 19 25





Characterized with brain problem Zika is virus of family Flaviviridae and named Microcephaly. There are number known to one of well known infectious of effective vaccine available for disease spread through bite of day time treatment of other Virus in Flaviviridae family. WHO experts have suggested that mosquito named Aedes aegypti. As history suggest name Zika came from the priority should be to develop forest Uganda. The infection known to be inactivated vaccines and other non-live vaccines, which are safe to use in Zika fever similar to Dengue fever. In pregnant women and those of 2015 to Mexico, Central America, the childbearing age. Caribbean, and South America, where the Zika outbreak has reached pandemic Here in Microbioz India April 2016 levels. Zika is most sensitive to pregnant edition of magazine we share one of women and infect new born baby fantastic cover story explains 10 interesting facts about Zika virus.

Gut microbiota transfer affects brain dysfunction and nerve fiber insulation: Recent study Multiple sclerosis is type of an autoimmune disease led by damage We are hopeful these metabolites can be targeted for potential future in myelin, the insulating sheath around the axons of nerve cells therapies.'In an effort to define the mechanism of gut-brain that allows for faster electrical impulse conduction. Myelination is communication, researchers identified bacterial communities critical for everyday brain function and damaged myelin results in associated with increased levels of cresol, a substance that has the number of brain dysfunction which includes altered synaptic ability to pass the blood-brain barrier. This current study led by transmission and clinical symptoms. Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomics, and Neurology, and Chief of the Center of Excellence for The researcher from The Mount Sinai Hospital / Mount Sinai School Myelin Repair, and post-doctoral fellow Mar Gacias, PhD, identifies of Medicine recently suggest targeting intestinal bacteria, or their bacteria-derived gut metabolites that can affect myelin content in the metabolites, could be one way to treat debilitating psychiatric brains of mice and induce depression-like symptoms. disorders and demyelinating diseases, like multiple sclerosis. The concern research recently appears in medical journal eLife. Note: The above story is for information purposes for more information go through original story source. According to researcher, Story source: The Mount Sinai Hospital / Mount Sinai School of 'Our findings will help in the understanding of microbiota in Medicine modulating multiple sclerosis,' says Dr. Casaccia. 'The study provides a proof of principle that gut metabolites have the ability Journal References: to affect myelin content irrespective of the genetic makeup of mice. Mar Gacias, Sevasti Gaspari, Patricia Mae-Santos, Sabrina Tamburini, Monica Andrade, Fan Zang, Nan Shen, Vladimir Tolstikov, Michael A Kiebish, Jeffrey L Dupree, Venetia Zachariou, Jose C Clemente, Patrizia Casaccia. Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior. eLife, 2016; 5 DOI: 10.7554/eLife.13442 18

Researcher finds new mechanism responsible for cancer approach: New hope for pancreatic cancer treatment As we all know pancreatic cancer is one of most serious Director of Surgical Research at Thomas Jefferson University. cancer type and few report suggest pancreatic cancer is 'Knocking out this resistance mechanism could make one leading cancer cause death by 2020.Researcher from pancreatic cancer vulnerable to therapies that had great Thomas Jefferson University recently finds new mechanism promise in the past. While there's more work to be done to that could be responsible for the cancer's resistance to at confirm the results in pre-clinical models and then humans, we least one targeted approach. If the results hold true in are encouraged by these preliminary results.' animal models and eventually clinical trials, the approach Note: The above story is for information purposes for more could help researchers develop more effective combination therapies and breathe new life into forgotten and failed information go through original story source. cancer drugs. Story source: Thomas Jefferson University The study recently appeared in journal Molecular Cancer Journal References: Research, Dr. Brody and colleagues showed that a protein called HuR (Hu antigen R) is a hub for cancer cell survival C. Romeo, M. C. Weber, M. Zarei, D. DeCicco, S. N. Chand, A. and drug resistance, especially when pancreatic cancer cells D. Lobo, J. M. Winter, J. A. Sawicki, J. N. Sachs, N. Meisner- are treated with TRAIL. Kober, C. J. Yeo, R. Vadigepalli, M. L. Tykocinski, J. R. Brody. HuR Contributes to TRAIL Resistance by Restricting Death According to researcher, 'We've teased out one mechanism Receptor 4 Expressions in Pancreatic Cancer Cells. Molecular behind pancreatic cancer cells' resistance to certain drugs,' Cancer Research, 2016; DOI: 10.1158/1541-7786.MCR-15- says Jonathan Brody, Ph.D., a researcher at the Sidney 0448 Kimmel Cancer Center at Thomas Jefferson University and 19



Now intake of antibodies and other drugs two to three times in a day is replaced by engineered pills Researcher from Massachusetts Institute of Technology As a sample testing researcher uses pigs intestinal tissue to designed engineered pills that releases drug for long term if test the adherence of pills they used three type of drug while once swallowed while attaching with inner lining of experimenting named, dual-sided Mucoadhesives tablet, a gastrointestinal tract. Pills engineered in such a way that dual-sided omniphobic tablet, and the Janus version, with one one side attach with tissue and other side repels foods and Mucoadhesives side and one omniphobic side. At the results liquids. find dual-sided Mucoadhesives tablets only adheres 7 seconds of time while dual-sided omniphobic tablet adheres less than The concern research appears in April 6 issue of the journal one seconds in turns Janus version adheres up to 10 Advanced Healthcare Materials. According to senior author minutes.'There are certain medications that are known to get of research, 'This could be adapted to many drugs. Any stuck, particularly in the esophagus. It causes this massive drug that is dosed frequently could be amenable to this amount of inflammation because it gets stuck and it causes kind of system,' says Giovanni Traverso, a research affiliate irritation,' Traverso says. at MIT's Koch Institute for Integrative Cancer Research, a gastroenterologist at Brigham and Women's Hospital. Note: The above story is for information purposes for more information go through original story source. The research one of senior author is Robert Langer, the David H. Koch Institute Professor and a member of the Story source: Massachusetts Institute of Technology Koch Institute and Young-Ah Lucy Lee is leading author of paper. Journal References: Make note that since last few years Langer laboratory Young-Ah Lucy Lee, Shiyi Zhang, Jiaqi Lin, Robert Langer and Giovanni Traverso. A Janus Mucoadhesive and Omniphobic developed number of drugs adhere with intestinal lining for Device for Gastrointestinal Retention. Advanced Healthcare long term drug release, they did this brilliant job by using compound named, “Mucoadhesives” which attaches drug Materials, April 2016 DOI: 10.1002/adhm.201501036 with inner linings of GI tract. 23