Guest Post Our Service Centres: Nashik, Mumbai, pune, Aurangabad, Hyderabad, Vishakhapatnam, We have technical expert team with technicians to handle complete after Bangalore, Chennai, Delhi, Baddi, Dehradun, sale services. Guwahati, Vapi, and Vadodara. Installation & commissioning of Contact us for more details: equipment’s. Mack Pharmatech Pvt Ltd Corporate / Factory Office: B-48, Malegaon MIDC, Sinnar, We undertake after sales services like Dist.-Nasik, Maharashtra 422 113, INDIA AMC’s, CMC’s, and Calibration & For Sales Enquiry Contact us on: Validation activities. Mobile : +91 9325965656 E-Mail : [email protected] 24x7 quality service by adopting For Service Enquiry Contact us on devising advanced manufacturing Mobile : +91 9320065656 technique to enhance quality. E-Mail : [email protected] Online technical Support whenever required. Our Sales Office: NASHIK, DELHI, HYDERABAD, GUJARAT, BANGALORE Microbioz India, September 2021 Edition | 51
Pharma News Still, it reiterated plans to start testing a vaccine adjusted to the highly infectious Delta variant of Provided more than 1 the virus on humans this month, part of a billion COVID-19 vaccine “comprehensive strategy to address variants, dose up until now: should the need arise in the future” BioNTech Alembic Pharma gets last BSource: Reuters approval from USFDA for ioNTech and partner Pfizer have OCD treatment drug supplied more than one billion doses of their COVID-19 vaccine as per July 21, a Source: PTI bigger number than delivered by competitor AstraZeneca, the German biotech group said on Drug firm Alembic Pharmaceuticals on Monday. Thursday said it has received final The supply tally, up from more than 700 million approval from the US health regulator for doses announced by the biotech firm in June, Clomipramine Hydrochloride capsules, used for compares with AstraZeneca saying late last the treatment of obsessions and compulsions in month that it and manufacturing partner Serum patients with Obsessive-Compulsive Disorder Institute of India had supplied a billion doses to (OCD). 170 countries at the time. The company has received final approval from the Based on delivery contracts for over 2.2 billion US Food and Drug Administration (USFDA) for doses so far, BioNTech said in a statement it its abbreviated new drug application (ANDA) for expects to accrue 15.9 billion euros ($18.7 billion) Clomipramine Hydrochloride Capsules USP in the in revenue from the vaccine this year, up from a strengths 25 mg, 50 mg, and 75 mg, Alembic May forecast of 12.4 billion euros. Pharmaceuticals said in a regulatory filing. The approved product is therapeutically equivalent That includes sales, milestone payments from to the reference-listed drug product Anafranil partners and a share of gross profit in its partners’ Capsules of SpecGX LLC. territories, the company added. Pfizer late last Clomipramine Hydrochloride Capsules are month raised its forecast for its share of 2021 indicated for the treatment of obsessions and vaccine sales to $33.5 billion. BioNTech added compulsions in patients with OCD. on Monday that it and Pfizer believe a third dose, following the established two-shot regimen, “has the potential to preserve the highest levels of protective efficacy against all currently tested variants, including Delta”, underscoring similar remarks made by its partner. Microbioz India, September 2021 Edition | 52
Pharma News Quoting IQVIA data, Clomipramine Hydrochloride Capsules USP 25 mg, 50 mg, and 75 mg have an estimated market size of USD 32 million for twelve months ending June 2021. Alembic has a cumulative total of 149 abbreviated new drug application (ANDA) approvals, which includes 131 final approvals and 18 tentative approvals, from USFDA. PTI SVK DRR DRR Consolidating “The study shows that fourteen days after a AstraZeneca and combined vaccination program, the risk of mRNA COVID-19 vaccine infection with SARS-CoV-2 is reduced by 88% is effective – Danish study compared to unvaccinated individuals,” the State Serum Institute (SSI) said. Source: PTI That is a “high efficacy”, SSI added, comparable to the 90% efficacy rate of two doses from Pfizer- Combining AstraZeneca’s COVID-19 vaccine with a second dose from either BioNTech’s vaccine, confirmed in a different Pfizer-BioNTech or Moderna’s jab Danish study. provides “good protection”, Denmark’s State The study, published last week, covered a span of Serum Institute said on Monday. more than five months between February and June A growing number of countries are looking at this year, a period in which the Alpha-variant of the switching to different COVID-19 vaccines for coronavirus was predominant. second doses, a measure particularly necessary in It could not conclude whether the same protection Denmark after health authorities discontinued inoculations with AstraZeneca’s vaccine in April applied to the Delta-variant, which is now the most over rare side-effect concerns. widespread in Denmark. More than 144,000 Danes, mostly frontline It also provided no efficacy data on COVID-19 personnel in the health sector and the elderly, related deaths or hospitalisations, since none took received their first jab with AstraZeneca’s vaccine place following the combined vaccination but were subsequently vaccinated with either programme. Pfizer-BioNTech or Moderna’s shots. Microbioz India, September 2021 Edition | 53
Product Launches Compact 4-Position High Pressure Benchtop Reactor Source: Asynt For further information on the Quadracell 4 position high pressure reactor please The Quadracell 4-position visit https://www.asynt.com/product/quadracell-4- high pressure reactor from position-high-pressure-reactor/ or contact Asynt Asynt is a new synthetic tool on +44-1638-781709 / [email protected]. for scientists seeking the The Quadracell is a new addition to the convenience of routine parallel comprehensive range of single and multi- pressure chemistry in a compact position high-performance pressure reactors footprint. from Asynt. To download a flyer providing a Designed and manufactured in the brief overview of the range please visit https://www.asynt.com/wp- UK, the robust Quadracell reactor is simple to content/uploads/2014/05/Asynt-Pressure- set up and to operate, with heating and agitation provided by a standard magnetic hotplate stirrer Reactors-Overview-Flyer-V2.1.pdf and magnetic flea. Constructed in durable Stainless Steel 316, the Asynt is a leading supplier of affordable Quadracell has four cells – each with a reaction products, consumables and services for chemists volume of 10 mL – that can routinely operate at in industry and academia. With a sales team of temperatures up to 250 °C. For labs using trained chemists, Asynt can draw upon their in- aggressive or caustic media the Quadracell is depth application knowledge to provide a high optionally available constructed from Hastelloy level of customer support for its DrySyn Heating C276 for enhanced chemical resistance. Blocks, CondenSyn waterless condensers, Turn- Different versions of the Quadracell are available Key solutions for Controlled Lab Reactors, to safely operate up to your chosen maximum Synthesis Tools, Evaporators, Temperature working pressure of 50, 100 or 200 Bar. Each Control Systems, Vacuum Pumps and Lab Safety Quadracell high pressure reactor is supplied as Equipment. standard with a pressure release valve, pressure gauge, gas inlet and gas outlet via two stainless steel needle valves. With a wide range of accessories available, you can tailor the package to suit your exact chemistry and laboratory setup or select a standard Quadracell turn-key solution that’s ready to use right away. Microbioz India, September 2021 Edition | 54
Product Launches About Biolinx India: BioLinx India Pvt. Ltd. was formed in early 2008 Biolinx India Biosafety with an idea of linking the Scientific Community Cabinets with Advanced to novel and cutting edge technology for Human Machine Interface improvising their research activities. Backed by (HMI) Touch Screen our excellent infrastructural facility and a display dedicated group of professionals we have succeeded in establishing ourselves as a preferred Source: Biolinx India and reliable source of laboratory, medical, scientific and research equipment. Lysis Buffer for High Yield Enzymatic Shearing Source: Chromatrap A Biosafety cabinet (BSC)— likewise called as biological safety cabinet or microbiological safety cabinet—is an enclosed, ventilated laboratory workspace for safely working with materials contaminated with (or potentially contaminated with) pathogens requiring a defined biosafety level. Salient features: 1. NSF | EN 12469 | CE Certified 2. Advanced human Machine Interface (HMI) Touch Screen display offers real time clock, date, inflow, downflow, negative plenum pressure, Porvair Sciences reports how its HEPA filter running hrs, UV lamp running hrs Chromatrap® Lysis buffer for enzymatic 3. Automatic Pre-purge/ Post-purge shearing provides users with a complete 4. Built in timer for UV light with interlock lysis buffer for the disruption of nuclear cell 5. High/Low inflow & downflow velocity alarms membranes with a milder detergent than that 6. Wrong window operation height alarms required for mechanical fragmentation. 7. Alarm for UV lamp exceeds the setting hour Lysis plays a crucial role in enabling researchers 8. Unit records inflow, downflow and Pressure to better explore and understand the underlying processes and mechanisms that drive biological For more information: organisms. Correct shearing is critical to the Girish Nair success of a ChIP assay. The buffer is compatible Founder, Director with all Porvair ChIP kits for enzymatic shearing Biolinx India Pvt Ltd from fixed cells or tissue. [email protected] Porvair’s Chromatrap® Lysis buffers are formulated to ensure that the nuclear membrane in your samples is disrupted releasing a high yield of nuclear material for your research. Microbioz India, September 2021 Edition | 55
Product Launches The new tool enables electronic pipette users to With the success of a ChIP assay being highly always stay up-to-date with the latest software dependent on the quality of chromatin prepared, improvements and new features for their using a Chromatrap® Lysis buffer reagent to isolate chromatin from your sample can play an Eppendorf Xplorer®, Xplorer plus, Xplorer plus important role in the success of this process. For further information please Move It® pipettes and/or Multipette® E3 and visit https://www.chromatrap.com/lysis-buffer-for- E3x multi-dispensers. enzymatic-shearing/ or contact Porvair Sciences A simple process to update in minutes Ltd on +44-1978-661144 / [email protected]. To perform an update, customers just need a Chromatrap is a brand of Porvair Sciences Ltd. Windows PC with internet connection, a micro- with R&D and production laboratories based in USB cable and the Eppendorf pipette or multi- the UK. Their extensive product range includes ChIP kits, DNA purification kits and other dispenser to be updated. When executing the innovative products for the life science market. Now cited in over thirty academic papers – Software Update Tool, it connects to the internet Chromatrap® ChIP technology is rapidly and checks for the latest software update on the becoming the method of choice for fast accurate ChIP assays. For further information please Eppendorf servers. If an update is available, it visit https://www.chromatrap.com/. can be carried out in just a few minutes. Update electronic pipettes independently without a Benefit from the latest improvements service technician The latest software improvements for Source: Eppendorf Eppendorf pipettes include an improved battery capacity measurement, improvements in the read With the Eppendorf Pipette Software & write function of user settings and new Update Tool, Eppendorf introduces a features for the Eppendorf Xplorer pipette line-up. new way for its liquid handling Details and download of the new Eppendorf customers to update the software of their Pipette Software Update Tool with step-by-step electronic pipettes or multi-dispensers on their instructions at www.eppendorf.com/software- own (without a service technician), for free and in just a few minutes. downloads About Eppendorf: Eppendorf is a leading life science company that develops and sells instruments, consumables, and services for liquid handling, sample handling, and cell handling in laboratories worldwide. Its product range includes pipettes and automated pipetting systems, dispensers, centrifuges, mixers, spectrometers, and DNA amplification equipment as well as ultra-low temperature freezers, fermentors, bioreactors, CO2 incubators, shakers, and cell manipulation systems. Consumables such as pipette tips, test tubes, microplates, and single-use bioreactor vessels complement the range of highest-quality premium products. Eppendorf products are most broadly used in academic and commercial research laboratories, e.g., in companies from the pharmaceutical and biotechnological as well as the chemical and food industries. They are also aimed at clinical and environmental analysis laboratories, forensics, and at industrial laboratories performing process analysis, production, and quality assurance. Microbioz India, September 2021 Edition | 56
Product Launches Eppendorf was founded in Hamburg, Germany, Research Institute in Australia have in 1945 and has about 4.500 employees developed a rapid method for worldwide. In 1961, Eppendorf launched the differentiating COVID-19-positive patients »Marburg Pipette« – the world’s first piston- expected to show severe symptoms from stroke pipette making it possible to handle liquids those likely to experience only mild in the microliter volume range for the very first symptoms. The classification algorithm, time – to learn more about the 60th Anniversary published in the journal Analytical of this occasion, follow the link below. The Chemistry, is based on infrared spectra company has subsidiaries in 26 countries and is of blood plasma, acquired on an Agilent represented in all other markets by distributors. Cary 630 FTIR Spectrometer. Researchers Develop The COVID-19 virus infected over 200 COVID-19 Severity million people in 220 countries and Screening Method Based territories in less than 18 months, on the Agilent Cary 630 FTIR Spectrometer overwhelming many healthcare systems 1. Resources such as ventilators and hospital beds Source: Agilent Technologies remain in extremely high demand, and shortages risk the lives of severely ill patients. However, not Agilent Technologies Inc. (NYSE: A) all COVID-19 patients experience symptoms announces that researchers at the Indian requiring intensive care. Early identification and Institute of Technology Bombay in India prioritization (triage) of patients based on and the QIMR Berghofer Medical severity can help free up resources and improve patient outcomes 2. This research has the potential to provide significant support to healthcare workers facing critical resource decisions. In the study, the researchers collected infrared spectra of blood plasma from 160 COVID- positive patients from Mumbai (130 as a training set for model development and 30 as a blind test set for model validation). The spectra, collected on a Cary 630 FTIR spectrometer equipped with a diamond-attenuated total reflectance (ATR) sampling module, revealed slight but observable differences between severe and non-severe COVID-19 patient samples. Associate Professor Michelle Hill, head of QIMR Berghofer’s Precision and Systems Biomedicine Research Group, and one of the lead scientists of the study explained: “We found there were measurable differences in the infra-red spectra in the patients who became severely unwell. In particular, there were differences in two infra-red regions that correspond to sugar and phosphate chemical groups, as well as primary amines, which occur in specific types of proteins.” Microbioz India, September 2021 Edition | 57
Product Launches Based on these differences, a multivariate About Agilent Technologies statistical model was developed and tested. Agilent is a leader in life sciences, diagnostics, Professor Sanjeeva Srivastava from the Indian and applied chemical markets, delivering innovative technology solutions that provide Institute of Technology Bombay added: “We trusted answers to researchers’ most challenging also found that having diabetes was a key scientific questions. The company generated predictor of becoming severely unwell in this revenue of $5.34 billion in fiscal year 2020 and group of patients, so we fed clinical parameters employs 16,400 people worldwide. such as age, sex, diabetes mellitus, and A Hot New Range of Heat- hypertension into the algorithm. We then tested Sealed Films for Microplates the algorithm on blood samples from a separate Source: Alpha Laboratories Ltd. group of 30 patients from Mumbai and found it was 69.2% specific and 94.1% sensitive in Protect your precious samples with the comprehensive new range of top quality predicting which patients would become severely plate seals now available from Alpha Laboratories. These high-performance ill.” heat-sealing films and foils are designed “However, it did result in more ‘false positives’ to meet the needs of your modern life than predictions that were based solely on the sciences laboratory clinical risk factors of age, sex, hypertension, and diabetes. We hope that with more testing, we can When sealing using heat, films or foils are welded reduce these false positives”, Professor to the microplate to produce a secure and Srivastava further explained. effective seal. Heat sealing can preserve your costly reagents and valuable samples, by creating Andrew Hind, Associate Vice President of an airtight and chemically resistant seal, without Research & Development for the Molecular the complications of using adhesives. Use heat Spectroscopy Division at Agilent, stated: “We are sealing to protect your well contents from very excited about this study, and happily evaporation, condensation, oxidation and cross- supported the researchers in their fight against contamination during experiments, transport or COVID-19 by placing the Cary 630 FTIR storage. spectrometer for this study. Their work highlights the potential of ATR-FTIR spectroscopy for COVID-19 and infectious disease research, and we will continue to support research in this field.” The Agilent Cary 630 FTIR spectrometer is a versatile and reliable instrument used by researchers in high-impact studies worldwide. Its ultra-compact form, simplicity, and ease of use make it ideal for seamless deployment in many settings and scenarios. It is particularly well suited for use in infectious disease research and the investigation of biological samples. It can be paired with powerful multivariate statistical analysis to allow researchers to link spectral information with qualitative, macroscopic properties. 1. Worldometers: Coronavirus Update (Live) Cases and Deaths from COVID-19 Virus Pandemic. 2021 2. WHO Western Pacific Region: Algorithm for COVID-19 triage and referral Microbioz India, September 2021 Edition | 58
Product Launches In addition, own brand lines of All of these films & foils are available in 125mm x 78mm individual sheets, which fit all standard essential SBS microplates. Seals are also available in roll laboratory formats for high throughput applications. consumables With a variety of materials used, the range include high includes products suitable for PCR, qPCR, peeling, piercing, low or high temperature quality storage, transport and temporary or long-term Pastette® protection. transfer pipettes, All products are certified free from nuclease and eco-friendly DNA except where specified.Available with Fastrak® pipette application specific features in individual sheets tips and or rolls, these films are suitable for numerous SpeciSafe® low, medium & high-throughput needs. UN3373 compliant About Alpha Laboratories Ltd. sample Established in 1975, Alpha Laboratories packaging provides quality support to healthcare solutions. The professionals for their diagnostic and laboratory company is BS product needs. Alongside routine requirements it EN ISO focuses on specialist biomarkers such as 9001:2008 and 14001:2004 accredited. calprotectin for IBD and faecal immunochemical testing for bowel cancer, to advance diagnostic Covid testing portal run by practice, provide better patient care and reduce software start up exceeds medical costs. one million tests and The extensive range of laboratory consumables spawns new venture includes pipette tips, pipettes, dispensers, microtubes, racks, electrophoresis and PCR Source: Personalised Diagnostics Ltd equipment, sourced from leading worldwide manufacturers. Testing portal has now facilitated the processing of more than 1.2 million tests Healthcare software entrepreneurs Clive Minihan and Andrew Halliday have had a busy 16 months. Predicting that the need to process Covid tests at scale would require the process to be digitised, the pair formed the startup Recova-19 in May 2020. Their testing portal has now facilitated the processing of more than 1.2 million tests with a team that has now grown to 10. The cloud-based SaaS platform application has proved so successful that the duo now plan to use it to further support resilience in the health care system in the crucial areas of point of care testing and remote diagnostics with a new venture, called Personalised Diagnostics Limited (PDX). Microbioz India, September 2021 Edition | 59
Product Launches It is intended that the new technology will be As the UK starts to emerge from this pandemic, available to improve the ease of data collection some big key questions remain to be resolved: and processing in clinical trials, innovative point how will the NHS grapple with the huge of care diagnostic products and, building on the diagnosis and treatment backlog that has built up and will the NHS be more open to how new company founders’ existing strong connections technologies might assist in that struggle? In with pharmacies and laboratories, personal AlbionVC’s Health Tech Primer for Europe,* genetic based tests in oncology, fertility and published this year, Christoph Ruedig, Partner at gastric health. Albion VC is quoted as saying, “Faced with an The platform has been some time in the making, existential crisis brought about by the acute strain being originally designed in 2012 to allow remote on providers from Covid-19, the entire industry data collection and diagnosis for the NHS and had to learn how to do things differently almost overnight. And it learned pretty quickly that was successfully adopted in Dermatology and technology holds the key to overcoming many of Sexual Health by NHS Wales. the challenges posed by the crisis. The Last spring the pair quickly recognised that the beneficiaries have again been technology platform’s ability to gather data remotely, store it vendors, in particular those that help move securely, and deliver results electronically would activities that traditionally happened face-to-face be crucial in dealing with Covid testing. Fifteen to remote.” months on, the company’s software is used by Additionally, given the concerns around the two of the top three high street pharmacy chains, inevitable delay in addressing the backlog, employers such as Cambridge University, and individuals may be more willing to manage their most of the UK’s UKAS accredited laboratories. healthcare privately through accessing clinical The company sends all Covid testing results to testing in the private market and accessing their Public Health England every morning. The own data in a secure and confidential portal portal has also recently been launched in Ireland. under their own control. These are all areas that Clive and Andrew, are keen to explore and they Clive says, “The success of the portal is based on are currently in discussion with clinical Andrew’s total commitment that software has to researchers, healthcare professionals and work, be user friendly, and be constructed using laboratories for whom remote data capture and agile methodology to enable adaptation for reporting is crucial. customer needs in an accelerated timeframe.” Clive concludes, “With a million results behind The advantages to the labs using the Recova us, we’ve shown our technology can reach scale and. with Personalised Diagnostics we aim to software is captured by Dr. Tony Cooke, Chief transform outcomes in healthcare for the future. Executive of Cambridge Clinical Laboratories; It’s a really exciting prospect for everyone.” “Using the Recova portal has transformed the time and potential mistakes in transcribing test About Personalised Diagnostics Ltd details; we simply check samples in using a barcode scanner and upload the results from our PD2X was set up by a team of professionals with Laboratory Information Management System over 120 years combined experience maximising the use of IT technology in improving the once processing is complete. The simplicity of effectiveness of clinical systems and processes. the process, plus the added bonus of using the The company’s founding partners are Clive Recova software to facilitate our reporting to Minihan and Andrew Halliday. PHE, allows us to focus on what we do best – processing clinical samples. Without Recova we could not have successfully scaled our operations to cope with Covid as we have.” Microbioz India, September 2021 Edition | 60
Product Launches Clive Minihan chromatography (LC) system. Designed for high sensitivity LC-mass spectrometry (LC-MS) A Harvard Business School graduate and mentor to applications, technical capabilities and seamless the NHS England Clinical Entrepreneurs Programme integration with Thermo Scientific PepMap Neo Clive recently Set up Recova-19, a software and Columns and Thermo Scientific mass-spectrometry testing solution to help employers and teaching portfolio, the new Thermo Scientific Vanquish Neo institutions manage the risk of Covid-19 within the UHPLC Systemand Thermo Scientific PepMap Neo workplace and place of learning, to make employee Columns help users overcome limitations of existing and student testing and monitoring safe, efficient and reliable. low-flow LC instruments.\"Low-flow LC users are limited by technical capacity and a high level of Andrew Halliday expertise required for system operation,\" said Kent Davidson, vice president and general Andrew studied Zoology at the University of Leeds manager, high performance chromatography and has a Master’s Degree in Biology from solutions, Thermo Fisher Scientific. \"The Manchester University. He went on to become Chief Vanquish Neo UHPLC System and PepMap Technology Officer at Signum Health, IT Project Neo Columns allow for long-term operation at Manager with ETJAM Limited and co-founded 3 maximum performance levels without Wise Monkeys, a company that helps to safeguard compromise. Enhanced ease-of-use and travelers against the hazards of diseases they would increased versatility enable users to push not normally encounter at home. He is a Director and science forward.\" co-founder of ReCoVa-19 with Clive Minihan. Professor Bernhard Kuster, Technical University Next-Generation Nano-, Munich, said, \"The Vanquish Neo UHPLC Capillary- and Micro-Flow System will transform how scientists perform LC Systems Enhance proteomics studies by providing the long-term Productivity and robustness and flow-range versatility required for Performance deep and fast LC-MS profiling of thousands of proteomes, while coupled with PepMap Source: Thermo Fisher Scientific Columns and high-resolution accurate mass (HRAM) systems.\" Thermo Scientific Vanquish Neo UHPLC System The new Thermo Scientific Vanquish Neo and Thermo Scientific PepMap Neo Columns UHPLC System and Thermo Scientific PepMap enable consistent, high-quality results in high- Neo Columns deliver application flexibility and sensitivity LC-MS workflows robust analytical performance at flow rates from 1 nL/min to 100 µL/min up to 1500 bar. Novice Principal investigators, laboratories, and proteomics and expert LC-MS users will enjoy accelerated researchers in academia, biopharma and contract productivity, reduced method overhead time, research organizations can now benefit from an all- and long-term operation essential for 24/7 large in-one nano-, capillary- and micro-flow liquid sample cohort analysis. Users of the Vanquish Neo UHPLC System and PepMap Neo Columns benefit from: Excellent separation performance, column-to- column reproducibility, and simple operation. Seamless integration with the comprehensive portfolio of Thermo Scientific mass spectrometers. Enhanced quantitation through high-injection volume linearity, precision and accuracy. Negligible system carryover with automated wash routines. Microbioz India, September 2021 Edition | 61
Product Launches System monitoring and control with automated The HRD tests will leverage Illumina's procedures and guided maintenance routines through the Thermo Scientific Vanquish User TruSight™ Oncology 500 (TSO 500) content, Interface. enabling the most comprehensive genomic For more information on the Thermo Scientific Vanquish Neo UHPLC System, please visit: profiling assays in a single workflow.This www.thermofisher.com/vanquishneo. For more information on the Thermo Scientific PepMap strategic partnership builds on an initial Neo Columns, please visit study conducted with Merck and http://www.thermofisher.com/lowflowHPLCc leverages Illumina's relationship with Myriad olumns. Genetics to expand international access to the About Thermo Fisher Scientific proprietary technology in Myriad's FDA approved myChoice® CDx companion Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue exceeding diagnostic test. $30 billion. Our Mission is to enable our customers to make Illumina will develop a new HRD CDx test for the world healthier, cleaner and safer. Whether the EU and the UK to aid in the identification of our customers are accelerating life sciences ovarian cancer patients with positive HRD status research, solving complex analytical challenges, who are eligible for treatment with improving patient diagnostics and therapies or LYNPARZA® (olaparib), a first-in-class PARP increasing productivity in their laboratories, we inhibitor, jointly developed and commercialized are here to support them. Our global team of by Merck and AstraZeneca. more than 80,000 colleagues delivers an In addition, Illumina will develop and unrivaled combination of innovative commercialize a research use only (RUO) HRD technologies, purchasing convenience and assay that will be add-on content for the TSO 500 pharmaceutical services through our industry- RUO panel. Illumina plans to launch this product leading brands, including Thermo Scientific, globally, excluding the United States and Japan. Applied Biosystems, Invitrogen, Fisher \"With such great advances in precision medicine Scientific, Unity Lab Services and Patheon. being made by companies such as Merck, it's essential that patients who would benefit from Illumina Partners with LYNPARZA are identified,\" said Joydeep Merck to Develop and Goswami, Chief Strategy and Corporate Commercialize Development Officer of Illumina. \"By leveraging Companion Diagnostic our comprehensive genomic profiling family of and Research Tests for products, TruSight™ Oncology, and the gold Use in Identifying Specific Cancer Mutations standard myChoice® HRD technology, Illumina aims to offer the best-in-class HRD assay that is Source: Illumina broadly accessible. By harnessing the incredible medicines development expertise of Merck, Illumina, Inc. and Merck (known as MSD together we will be able to leverage the use of outside the United States and Canada) have precision medicines to make a real difference for announced a partnership to develop and patients.\" commercialize tests that identify genetic \"HRD testing should be an essential component mutations used in the assessment of homologous of clinical diagnosis as half of all newly diagnosed recombination deficiency (HRD). Patients whose patients with advanced ovarian cancer have tumors are HRD-positive may be eligible for HRD-positive tumors,\" said Dr. Eric H. Rubin, targeted treatment by a class of precision senior vice president, early-stage development, medicines called PARP inhibitors. clinical oncology, Merck Research Laboratories. Microbioz India, September 2021 Edition | 62
Product Launches About Illumina \"Biomarker testing has rapidly enhanced our Illumina is improving human health by unlocking understanding of how PARP inhibition can help the power of the genome. Our focus on target a devastating disease, like ovarian cancer innovation has established us as the global leader and we are excited to partner with Illumina on in DNA sequencing and array-based the development of a distributed CDx HRD technologies, serving customers in the research, assay for the EU and UK.\" clinical and applied markets. Our products are This collaboration with Merck expands on used for applications in the life sciences, Illumina's solid history and broad portfolio of oncology, reproductive health, agriculture and oncology partnerships with industry leaders, with other emerging segments. the united goal of advancing cancer diagnostics and precision medicine. Gilson's New VERITY® 1741 UV-VIS Detector - About TruSight Oncology 500 Specially Designed to Secure Semi-Preparative TSO 500 is a Research Use Only pan-cancer and Preparative HPLC assay that enables Comprehensive Genomic Applications Profiling. Source: Gilson UK Designed to identify known and emerging tumor biomarkers across 523 genes, TSO 500 utilizes Gilson has announced a new UV- both DNA and RNA from tumor samples to VIS detector to its VERITY® line of identify key variants critical for cancer purification systems. development and progression, such as small DNA variants, fusions, and splice variants. In The VERITY® 1741 UV-VIS Detector is specifically addition, the assay assesses key immune- designed with the needs of semi-preparative and oncology biomarkers, such as Tumor Mutational preparative HPLC customers in mind. It relies on the Burden (TMB) and Microsatellite Instability power of UV-VIS with diode array detection (DAD) (MSI). Due to its comprehensive biomarker technology, like that found in Gilson's popular PLC content, labs can consolidate multiple single gene Purification Systems. The VERITY 1741 Detector is or small panel workflows into a single assay, an ideal solution for purification applications in drug saving biopsy specimen and time. Based on the discovery, food supplements, natural products, and content of TSO 500, Illumina will be adding an in biomolecular research. vitro diagnostic (IVD) test to the TSO product family. This comprehensive tumor profiling assay will have similar chemistry and analytics to TSO 500. About Myriad Genetics and myChoice® CDx Myriad Genetics is a leading genetic testing and precision medicine company dedicated to improving health and well being for all. Myriad's myChoice CDx companion diagnostic test is the first and only FDA-approved tumor test that determines homologous recombination deficiency status by detecting BRCA1 and BRCA2 (sequencing and large rearrangement) variants and assessing genomic instability using three critical biomarkers: loss of heterozygosity, telomeric allelic imbalance and large-scale state transitions. It has been referred to as \"The most comprehensive Tumor test to determine HRD status in patients with ovarian cancer.\" Microbioz India, September 2021 Edition | 63
Product Launches HORIBA to showcase novel POCKIT Central PCR When controlled by Gilson's analyser at BEVA and Vets TRILUTION® LC Software to North power up Gilson's VERITY® line of purification systems, the reliable source: HORIBA Medical VERITY 1741 Detector offers a 200-800 nm scanning range and Why wait for results? Vets can see for multiple different wavelength themselves how easy it is to do in-house detection simultaneously, which can PCR testing significantly increase purification specificity. Spectra can also be HORIBA UK Limited will be showcasing its viewed in real-time, allowing new benchtop POCKIT™ Central* in- researchers to quickly identify co- house veterinary PCR analyser on Stand C3 eluting impurities or other at the BEVA Congress, Birmingham, 4-7 September. separation details. The extensive HORIBA’s first live event this year will give visitors range of path flow cells makes the the opportunity to see how easy it is to carry out in- detector highly versatile to a wide house PCR Testing on the POCKIT Central. The array of compound concentrations simple “sample in, result out” process provides fast, and purification schemes. accurate PCR testing in only in 85 mins for up to 8 pathogens in one run. Ideally suited to veterinary The detector features a built-in practices, the POCKIT Central ensures confident counter for monitoring lamp life, diagnostic and case management decision making which helps users avoid without needing to wait for external laboratory interruptions and sample loss during results. a purification. The detector also uses easy to replace long-lasting lamps and flow cells, resulting in less instrument downtime. Gilson's service experience with similar PLC detectors translate to minimizing the cost of ownership. The VERITY 1741 Detector is easy to use and maintain while providing extended detection power. About Gilson Gilson is a family-owned global manufacturer of sample management, purification, and extraction solutions for the life sciences industry. We help researchers advance the pace of discovery by creating easy-to-use lab devices that improve reproducibility and traceability. Since 1957, we've been developing innovative products, such as the first continuously adjustable-volume pipette, PIPETMAN®. By partnering closely with the scientific community, we have advanced our portfolio offerings, adding automated pipetting systems and chromatography instruments, plus intuitive software management capabilities. Backed by worldwide R&D, service, and support, Gilson strives to enable verifiable science and to make lab life easier for our customers. Microbioz India, September 2021 Edition | 64
Product Launches The POCKIT Central offers more than 190 PCR tests, including over 30 new ones, tailored to Equine, Small Animal and Farm practices, with specialist assays for Poultry and Aquaculture. Equine diagnostic tests include Theileria equi, Pseudomonas aeruginosa, Streptococcus equi, EHV, Taylorella equigenitalis and influenza, and other new tests include Lyme disease, Dirofilaria immitis, Neospora caninum, Mec A gene for MRSA and IBR. BEVA visitors will also be able to see HORIBA’s INTEGRA produce high-quality GripTips that LAQUAtwin Ca-11C waterproof, pocket ionised are only compatible with their own innovative calcium (iCa) meter for on-site monitoring of ionised pipetting products, so it has always been their top calcium, and HORIBA experts will be on hand to talk priority to be able to supply their customers with about the PC400 clinical chemistry analyser. pipette tips whenever needed. HORIBA UK will also participate in Vets North (Haydock Park Racecourse, 15-16 September) so vets To fully guarantee tip availability, INTEGRA of all specialities can see HORIBA’s accurate produce pipette tips in excess of market demand. diagnostic instruments and discuss their use with the When testing for SARS-CoV-2 increased this HORIBA Team. demand to unprecedented levels in early 2020, * available from HORIBA in selected countries in INTEGRA started to massively increase tip Europe production capacities. As a result, INTEGRA offers one of the very few pipettes today which INTEGRA guarantees your can provide a steady and reliable supply of lab a steady supply of high- pipette tips. quality pipette tips If your lab has been facing tip shortages, we are honored to extend our tip pledge to you as well. Source: Integra Biosciences AG Contact us to see how INTEGRA pipettes can help make you more productive and precise. Order your pipetting device with guaranteed tip supply today. I NTEGRA promise all their customers a consistent and reliable supply of pipette tips. How can they make this claim? Simple. Microbioz India, September 2021 Edition | 65
Microbioz India, September 2021 Edition | 66
Microbioz India, September 2021 Edition | 67
PUBLISHED ON: 25th September 2021 RNI NUMBER: UPENG/2017/73675 Microbioz India, September 2021 Edition | 68
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