Guest Post We have technical expert team with Our Service Centres: Nashik, Mumbai, pune, technicians to handle complete after Aurangabad, Hyderabad, Vishakhapatnam, sale services. Bangalore, Chennai, Delhi, Baddi, Dehradun, Installation & commissioning of Guwahati, Vapi, and Vadodara. equipment’s. Contact us for more details: We undertake after sales services like AMC’s, CMC’s, and Calibration & Mack Pharmatech Pvt Ltd Validation activities. Corporate / Factory Office: B-48, Malegaon MIDC, Sinnar, 24x7 quality service by adopting devising advanced manufacturing Dist.-Nasik, Maharashtra 422 113, INDIA technique to enhance quality. For Sales Enquiry Contact us on: Online technical Support whenever required. Mobile : +91 9325965656 Our Sales Office: NASHIK, DELHI, E-Mail : [email protected] HYDERABAD, GUJARAT, BANGALORE For Service Enquiry Contact us on Mobile : +91 9320065656 E-Mail : [email protected] Microbioz India, September 2021 Edition | 51
Pharma News Still, it reiterated plans to start testing a vaccine adjusted to the highly infectious Delta variant of Provided more than 1 the virus on humans this month, part of a billion COVID-19 vaccine “comprehensive strategy to address variants, dose up until now: should the need arise in the future” BioNTech Alembic Pharma gets last Source: Reuters approval from USFDA for OCD treatment drug BioNTech and partner Pfizer have supplied more than one billion doses of Source: PTI their COVID-19 vaccine as per July 21, a bigger number than delivered by competitor Drug firm Alembic Pharmaceuticals on AstraZeneca, the German biotech group said on Thursday said it has received final Monday. approval from the US health regulator for The supply tally, up from more than 700 million Clomipramine Hydrochloride capsules, used for doses announced by the biotech firm in June, the treatment of obsessions and compulsions in compares with AstraZeneca saying late last patients with Obsessive-Compulsive Disorder month that it and manufacturing partner Serum (OCD). Institute of India had supplied a billion doses to The company has received final approval from the 170 countries at the time. US Food and Drug Administration (USFDA) for Based on delivery contracts for over 2.2 billion its abbreviated new drug application (ANDA) for doses so far, BioNTech said in a statement it Clomipramine Hydrochloride Capsules USP in the expects to accrue 15.9 billion euros ($18.7 billion) strengths 25 mg, 50 mg, and 75 mg, Alembic in revenue from the vaccine this year, up from a Pharmaceuticals said in a regulatory filing. May forecast of 12.4 billion euros. The approved product is therapeutically equivalent to the reference-listed drug product Anafranil That includes sales, milestone payments from Capsules of SpecGX LLC. partners and a share of gross profit in its partners’ Clomipramine Hydrochloride Capsules are territories, the company added. Pfizer late last indicated for the treatment of obsessions and month raised its forecast for its share of 2021 compulsions in patients with OCD. vaccine sales to $33.5 billion. BioNTech added on Monday that it and Pfizer believe a third dose, following the established two-shot regimen, “has the potential to preserve the highest levels of protective efficacy against all currently tested variants, including Delta”, underscoring similar remarks made by its partner. Microbioz India, September 2021 Edition | 52
Pharma News Quoting IQVIA data, Clomipramine Hydrochloride Capsules USP 25 mg, 50 mg, and 75 mg have an estimated market size of USD 32 million for twelve months ending June 2021. Alembic has a cumulative total of 149 abbreviated new drug application (ANDA) approvals, which includes 131 final approvals and 18 tentative approvals, from USFDA. PTI SVK DRR DRR Consolidating “The study shows that fourteen days after a AstraZeneca and combined vaccination program, the risk of mRNA COVID-19 vaccine infection with SARS-CoV-2 is reduced by 88% is effective – Danish study compared to unvaccinated individuals,” the State Serum Institute (SSI) said. Source: PTI That is a “high efficacy”, SSI added, comparable to the 90% efficacy rate of two doses from Pfizer- Combining AstraZeneca’s COVID-19 BioNTech’s vaccine, confirmed in a different vaccine with a second dose from either Danish study. Pfizer-BioNTech or Moderna’s jab The study, published last week, covered a span of provides “good protection”, Denmark’s State more than five months between February and June Serum Institute said on Monday. this year, a period in which the Alpha-variant of the A growing number of countries are looking at coronavirus was predominant. switching to different COVID-19 vaccines for It could not conclude whether the same protection second doses, a measure particularly necessary in applied to the Delta-variant, which is now the most Denmark after health authorities discontinued widespread in Denmark. inoculations with AstraZeneca’s vaccine in April It also provided no efficacy data on COVID-19 over rare side-effect concerns. related deaths or hospitalisations, since none took More than 144,000 Danes, mostly frontline place following the combined vaccination personnel in the health sector and the elderly, programme. received their first jab with AstraZeneca’s vaccine but were subsequently vaccinated with either Pfizer-BioNTech or Moderna’s shots. Microbioz India, September 2021 Edition | 53
Product Launches Compact 4-Position High Pressure Benchtop Reactor Source: Asynt For further information on the Quadracell 4 position high pressure reactor please The Quadracell 4-position visit https://www.asynt.com/product/quadracell-4- high pressure reactor from position-high-pressure-reactor/ or contact Asynt Asynt is a new synthetic tool on +44-1638-781709 / [email protected]. for scientists seeking the The Quadracell is a new addition to the convenience of routine parallel comprehensive range of single and multi- pressure chemistry in a compact position high-performance pressure reactors footprint. from Asynt. To download a flyer providing a Designed and manufactured in the brief overview of the range please UK, the robust Quadracell reactor is simple to visit https://www.asynt.com/wp- set up and to operate, with heating and agitation content/uploads/2014/05/Asynt-Pressure- provided by a standard magnetic hotplate stirrer Reactors-Overview-Flyer-V2.1.pdf and magnetic flea. Asynt is a leading supplier of affordable Constructed in durable Stainless Steel 316, the products, consumables and services for chemists Quadracell has four cells – each with a reaction in industry and academia. With a sales team of volume of 10 mL – that can routinely operate at trained chemists, Asynt can draw upon their in- temperatures up to 250 °C. For labs using depth application knowledge to provide a high aggressive or caustic media the Quadracell is level of customer support for its DrySyn Heating optionally available constructed from Hastelloy Blocks, CondenSyn waterless condensers, Turn- C276 for enhanced chemical resistance. Key solutions for Controlled Lab Reactors, Different versions of the Quadracell are available Synthesis Tools, Evaporators, Temperature to safely operate up to your chosen maximum Control Systems, Vacuum Pumps and Lab Safety working pressure of 50, 100 or 200 Bar. Each Equipment. Quadracell high pressure reactor is supplied as standard with a pressure release valve, pressure gauge, gas inlet and gas outlet via two stainless steel needle valves. With a wide range of accessories available, you can tailor the package to suit your exact chemistry and laboratory setup or select a standard Quadracell turn-key solution that’s ready to use right away. Microbioz India, September 2021 Edition | 54
Product Launches About Biolinx India: BioLinx India Pvt. Ltd. was formed in early 2008 Biolinx India Biosafety with an idea of linking the Scientific Community Cabinets with Advanced to novel and cutting edge technology for Human Machine Interface improvising their research activities. Backed by (HMI) Touch Screen our excellent infrastructural facility and a display dedicated group of professionals we have succeeded in establishing ourselves as a preferred Source: Biolinx India and reliable source of laboratory, medical, scientific and research equipment. Lysis Buffer for High Yield Enzymatic Shearing Source: Chromatrap A Biosafety cabinet (BSC)— likewise called as biological safety cabinet or microbiological safety cabinet—is an enclosed, ventilated laboratory workspace for safely working with materials contaminated with (or potentially contaminated with) pathogens requiring a defined biosafety level. Salient features: 1. NSF | EN 12469 | CE Certified 2. Advanced human Machine Interface (HMI) Touch Screen display offers real time clock, date, Porvair Sciences reports how its Chromatrap® Lysis buffer for enzymatic inflow, downflow, negative plenum pressure, shearing provides users with a complete lysis buffer for the disruption of nuclear cell HEPA filter running hrs, UV lamp running hrs membranes with a milder detergent than that required for mechanical fragmentation. 3. Automatic Pre-purge/ Post-purge Lysis plays a crucial role in enabling researchers to better explore and understand the underlying 4. Built in timer for UV light with interlock processes and mechanisms that drive biological organisms. Correct shearing is critical to the 5. High/Low inflow & downflow velocity alarms success of a ChIP assay. The buffer is compatible with all Porvair ChIP kits for enzymatic shearing 6. Wrong window operation height alarms from fixed cells or tissue. Porvair’s Chromatrap® Lysis buffers are 7. Alarm for UV lamp exceeds the setting hour formulated to ensure that the nuclear membrane in your samples is disrupted releasing a high yield 8. Unit records inflow, downflow and Pressure of nuclear material for your research. For more information: Girish Nair Founder, Director Biolinx India Pvt Ltd [email protected] Microbioz India, September 2021 Edition | 55
Product Launches With the success of a ChIP assay being highly The new tool enables electronic pipette users to dependent on the quality of chromatin prepared, using a Chromatrap® Lysis buffer reagent to always stay up-to-date with the latest software isolate chromatin from your sample can play an important role in the success of this process. improvements and new features for their For further information please visit https://www.chromatrap.com/lysis-buffer-for- Eppendorf Xplorer®, Xplorer plus, Xplorer plus enzymatic-shearing/ or contact Porvair Sciences Ltd on +44-1978-661144 Move It® pipettes and/or Multipette® E3 and / [email protected]. Chromatrap is a brand of Porvair Sciences Ltd. E3x multi-dispensers. with R&D and production laboratories based in the UK. Their extensive product range includes A simple process to update in minutes ChIP kits, DNA purification kits and other innovative products for the life science market. To perform an update, customers just need a Now cited in over thirty academic papers – Chromatrap® ChIP technology is rapidly Windows PC with internet connection, a micro- becoming the method of choice for fast accurate ChIP assays. For further information please USB cable and the Eppendorf pipette or multi- visit https://www.chromatrap.com/. dispenser to be updated. When executing the Update electronic pipettes independently without a Software Update Tool, it connects to the internet service technician and checks for the latest software update on the Source: Eppendorf Eppendorf servers. If an update is available, it With the Eppendorf Pipette Software Update Tool, Eppendorf introduces a can be carried out in just a few minutes. new way for its liquid handling customers to update the software of their Benefit from the latest improvements electronic pipettes or multi-dispensers on their own (without a service technician), for free and The latest software improvements for in just a few minutes. Eppendorf pipettes include an improved battery capacity measurement, improvements in the read & write function of user settings and new features for the Eppendorf Xplorer pipette line-up. Details and download of the new Eppendorf Pipette Software Update Tool with step-by-step instructions at www.eppendorf.com/software- downloads About Eppendorf: Eppendorf is a leading life science company that develops and sells instruments, consumables, and services for liquid handling, sample handling, and cell handling in laboratories worldwide. Its product range includes pipettes and automated pipetting systems, dispensers, centrifuges, mixers, spectrometers, and DNA amplification equipment as well as ultra-low temperature freezers, fermentors, bioreactors, CO2 incubators, shakers, and cell manipulation systems. Consumables such as pipette tips, test tubes, microplates, and single-use bioreactor vessels complement the range of highest-quality premium products. Eppendorf products are most broadly used in academic and commercial research laboratories, e.g., in companies from the pharmaceutical and biotechnological as well as the chemical and food industries. They are also aimed at clinical and environmental analysis laboratories, forensics, and at industrial laboratories performing process analysis, production, and quality assurance. Microbioz India, September 2021 Edition | 56
Product Launches Eppendorf was founded in Hamburg, Germany, Research Institute in Australia have in 1945 and has about 4.500 employees developed a rapid method for worldwide. In 1961, Eppendorf launched the differentiating COVID-19-positive patients »Marburg Pipette« – the world’s first piston- expected to show severe symptoms from stroke pipette making it possible to handle liquids those likely to experience only mild in the microliter volume range for the very first symptoms. The classification algorithm, time – to learn more about the 60th Anniversary published in the journal Analytical of this occasion, follow the link below. The Chemistry, is based on infrared spectra company has subsidiaries in 26 countries and is of blood plasma, acquired on an Agilent represented in all other markets by distributors. Cary 630 FTIR Spectrometer. Researchers Develop The COVID-19 virus infected over 200 COVID-19 Severity million people in 220 countries and Screening Method Based territories in less than 18 months, on the Agilent Cary 630 overwhelming many healthcare systems 1. FTIR Spectrometer Resources such as ventilators and hospital beds remain in extremely high demand, and shortages Source: Agilent Technologies risk the lives of severely ill patients. However, not all COVID-19 patients experience symptoms requiring intensive care. Early identification and prioritization (triage) of patients based on severity can help free up resources and improve patient outcomes 2. This research has the potential to provide significant support to healthcare workers facing critical resource decisions. In the study, the researchers collected infrared spectra of blood plasma from 160 COVID- positive patients from Mumbai (130 as a training set for model development and 30 as a blind test set for model validation). The spectra, collected on a Cary 630 FTIR spectrometer equipped with a diamond-attenuated total reflectance (ATR) sampling module, revealed slight but observable differences between severe and non-severe COVID-19 patient samples. Agilent Technologies Inc. (NYSE: A) Associate Professor Michelle Hill, head of QIMR announces that researchers at the Indian Berghofer’s Precision and Systems Biomedicine Institute of Technology Bombay in India Research Group, and one of the lead scientists of and the QIMR Berghofer Medical the study explained: “We found there were measurable differences in the infra-red spectra in the patients who became severely unwell. In particular, there were differences in two infra-red regions that correspond to sugar and phosphate chemical groups, as well as primary amines, which occur in specific types of proteins.” Microbioz India, September 2021 Edition | 57
Product Launches Based on these differences, a multivariate About Agilent Technologies statistical model was developed and tested. Agilent is a leader in life sciences, diagnostics, Professor Sanjeeva Srivastava from the Indian and applied chemical markets, delivering innovative technology solutions that provide Institute of Technology Bombay added: “We trusted answers to researchers’ most challenging scientific questions. The company generated also found that having diabetes was a key revenue of $5.34 billion in fiscal year 2020 and employs 16,400 people worldwide. predictor of becoming severely unwell in this A Hot New Range of Heat- group of patients, so we fed clinical parameters Sealed Films for Microplates such as age, sex, diabetes mellitus, and Source: Alpha Laboratories Ltd. hypertension into the algorithm. We then tested the algorithm on blood samples from a separate group of 30 patients from Mumbai and found it was 69.2% specific and 94.1% sensitive in predicting which patients would become severely ill.” “However, it did result in more ‘false positives’ than predictions that were based solely on the clinical risk factors of age, sex, hypertension, and diabetes. We hope that with more testing, we can reduce these false positives”, Professor Srivastava further explained. Andrew Hind, Associate Vice President of Protect your precious samples with the Research & Development for the Molecular comprehensive new range of top quality Spectroscopy Division at Agilent, stated: “We are plate seals now available from Alpha very excited about this study, and happily Laboratories. These high-performance supported the researchers in their fight against heat-sealing films and foils are designed COVID-19 by placing the Cary 630 FTIR to meet the needs of your modern life spectrometer for this study. Their work sciences laboratory highlights the potential of ATR-FTIR spectroscopy for COVID-19 and infectious When sealing using heat, films or foils are welded disease research, and we will continue to support to the microplate to produce a secure and research in this field.” effective seal. Heat sealing can preserve your costly reagents and valuable samples, by creating The Agilent Cary 630 FTIR spectrometer is a an airtight and chemically resistant seal, without versatile and reliable instrument used by the complications of using adhesives. Use heat researchers in high-impact studies worldwide. Its sealing to protect your well contents from ultra-compact form, simplicity, and ease of use evaporation, condensation, oxidation and cross- make it ideal for seamless deployment in many contamination during experiments, transport or settings and scenarios. It is particularly well suited storage. for use in infectious disease research and the investigation of biological samples. It can be paired with powerful multivariate statistical analysis to allow researchers to link spectral information with qualitative, macroscopic properties. 1. Worldometers: Coronavirus Update (Live) Cases and Deaths from COVID-19 Virus Pandemic. 2021 2. WHO Western Pacific Region: Algorithm for COVID-19 triage and referral Microbioz India, September 2021 Edition | 58
Product Launches All of these films & foils are available in 125mm In addition, own x 78mm individual sheets, which fit all standard brand lines of SBS microplates. Seals are also available in roll formats for high throughput applications. essential With a variety of materials used, the range laboratory includes products suitable for PCR, qPCR, consumables peeling, piercing, low or high temperature include high storage, transport and temporary or long-term protection. quality Pastette® All products are certified free from nuclease and transfer pipettes, DNA except where specified.Available with eco-friendly application specific features in individual sheets Fastrak® pipette or rolls, these films are suitable for numerous tips and low, medium & high-throughput needs. SpeciSafe® UN3373 About Alpha Laboratories Ltd. compliant Established in 1975, Alpha Laboratories sample provides quality support to healthcare packaging professionals for their diagnostic and laboratory solutions. The product needs. Alongside routine requirements it company is BS focuses on specialist biomarkers such as EN ISO calprotectin for IBD and faecal immunochemical 9001:2008 and 14001:2004 accredited. testing for bowel cancer, to advance diagnostic practice, provide better patient care and reduce Covid testing portal run by medical costs. The extensive range of laboratory consumables software start up exceeds includes pipette tips, pipettes, dispensers, microtubes, racks, electrophoresis and PCR one million tests and equipment, sourced from leading worldwide manufacturers. spawns new venture Source: Personalised Diagnostics Ltd Testing portal has now facilitated the processing of more than 1.2 million tests Healthcare software entrepreneurs Clive Minihan and Andrew Halliday have had a busy 16 months. Predicting that the need to process Covid tests at scale would require the process to be digitised, the pair formed the startup Recova-19 in May 2020. Their testing portal has now facilitated the processing of more than 1.2 million tests with a team that has now grown to 10. The cloud-based SaaS platform application has proved so successful that the duo now plan to use it to further support resilience in the health care system in the crucial areas of point of care testing and remote diagnostics with a new venture, called Personalised Diagnostics Limited (PDX). Microbioz India, September 2021 Edition | 59
Product Launches It is intended that the new technology will be As the UK starts to emerge from this pandemic, available to improve the ease of data collection some big key questions remain to be resolved: and processing in clinical trials, innovative point how will the NHS grapple with the huge of care diagnostic products and, building on the diagnosis and treatment backlog that has built up company founders’ existing strong connections and will the NHS be more open to how new with pharmacies and laboratories, personal technologies might assist in that struggle? In genetic based tests in oncology, fertility and AlbionVC’s Health Tech Primer for Europe,* gastric health. published this year, Christoph Ruedig, Partner at The platform has been some time in the making, Albion VC is quoted as saying, “Faced with an being originally designed in 2012 to allow remote existential crisis brought about by the acute strain data collection and diagnosis for the NHS and on providers from Covid-19, the entire industry was successfully adopted in Dermatology and had to learn how to do things differently almost Sexual Health by NHS Wales. overnight. And it learned pretty quickly that Last spring the pair quickly recognised that the technology holds the key to overcoming many of platform’s ability to gather data remotely, store it the challenges posed by the crisis. The securely, and deliver results electronically would beneficiaries have again been technology be crucial in dealing with Covid testing. Fifteen vendors, in particular those that help move months on, the company’s software is used by activities that traditionally happened face-to-face two of the top three high street pharmacy chains, to remote.” employers such as Cambridge University, and Additionally, given the concerns around the most of the UK’s UKAS accredited laboratories. inevitable delay in addressing the backlog, The company sends all Covid testing results to individuals may be more willing to manage their Public Health England every morning. The healthcare privately through accessing clinical portal has also recently been launched in Ireland. testing in the private market and accessing their Clive says, “The success of the portal is based on own data in a secure and confidential portal Andrew’s total commitment that software has to under their own control. These are all areas that work, be user friendly, and be constructed using Clive and Andrew, are keen to explore and they agile methodology to enable adaptation for are currently in discussion with clinical customer needs in an accelerated timeframe.” researchers, healthcare professionals and The advantages to the labs using the Recova laboratories for whom remote data capture and software is captured by Dr. Tony Cooke, Chief reporting is crucial. Executive of Cambridge Clinical Laboratories; Clive concludes, “With a million results behind “Using the Recova portal has transformed the us, we’ve shown our technology can reach scale time and potential mistakes in transcribing test and. with Personalised Diagnostics we aim to details; we simply check samples in using a transform outcomes in healthcare for the future. barcode scanner and upload the results from our It’s a really exciting prospect for everyone.” Laboratory Information Management System once processing is complete. The simplicity of About Personalised Diagnostics Ltd the process, plus the added bonus of using the Recova software to facilitate our reporting to PD2X was set up by a team of professionals with PHE, allows us to focus on what we do best – over 120 years combined experience maximising processing clinical samples. Without Recova we the use of IT technology in improving the could not have successfully scaled our operations effectiveness of clinical systems and processes. to cope with Covid as we have.” The company’s founding partners are Clive Minihan and Andrew Halliday. Microbioz India, September 2021 Edition | 60
Product Launches Clive Minihan chromatography (LC) system. Designed for high sensitivity LC-mass spectrometry (LC-MS) A Harvard Business School graduate and mentor to applications, technical capabilities and seamless the NHS England Clinical Entrepreneurs Programme integration with Thermo Scientific PepMap Neo Clive recently Set up Recova-19, a software and Columns and Thermo Scientific mass-spectrometry testing solution to help employers and teaching portfolio, the new Thermo Scientific Vanquish Neo institutions manage the risk of Covid-19 within the UHPLC Systemand Thermo Scientific PepMap Neo workplace and place of learning, to make employee Columns help users overcome limitations of existing and student testing and monitoring safe, efficient and reliable. low-flow LC instruments.\"Low-flow LC users are limited by technical capacity and a high level of Andrew Halliday expertise required for system operation,\" said Kent Davidson, vice president and general Andrew studied Zoology at the University of Leeds manager, high performance chromatography and has a Master’s Degree in Biology from solutions, Thermo Fisher Scientific. \"The Manchester University. He went on to become Chief Vanquish Neo UHPLC System and PepMap Technology Officer at Signum Health, IT Project Neo Columns allow for long-term operation at Manager with ETJAM Limited and co-founded 3 maximum performance levels without Wise Monkeys, a company that helps to safeguard compromise. Enhanced ease-of-use and travelers against the hazards of diseases they would increased versatility enable users to push not normally encounter at home. He is a Director and science forward.\" co-founder of ReCoVa-19 with Clive Minihan. Professor Bernhard Kuster, Technical University Next-Generation Nano-, Munich, said, \"The Vanquish Neo UHPLC Capillary- and Micro-Flow System will transform how scientists perform LC Systems Enhance proteomics studies by providing the long-term Productivity and robustness and flow-range versatility required for Performance deep and fast LC-MS profiling of thousands of proteomes, while coupled with PepMap Source: Thermo Fisher Scientific Columns and high-resolution accurate mass (HRAM) systems.\" The new Thermo Scientific Vanquish Neo UHPLC System and Thermo Scientific PepMap Neo Columns deliver application flexibility and robust analytical performance at flow rates from 1 nL/min to 100 µL/min up to 1500 bar. Novice and expert LC-MS users will enjoy accelerated productivity, reduced method overhead time, and long-term operation essential for 24/7 large sample cohort analysis. Thermo Scientific Vanquish Neo UHPLC System Users of the Vanquish Neo UHPLC and Thermo Scientific PepMap Neo Columns enable consistent, high-quality results in high- System and PepMap Neo Columns sensitivity LC-MS workflows benefit from: Principal investigators, laboratories, and proteomics Excellent separation performance, column-to- researchers in academia, biopharma and contract column reproducibility, and simple operation. research organizations can now benefit from an all- Seamless integration with the comprehensive in-one nano-, capillary- and micro-flow liquid portfolio of Thermo Scientific mass spectrometers. Enhanced quantitation through high-injection volume linearity, precision and accuracy. Negligible system carryover with automated wash routines. Microbioz India, September 2021 Edition | 61
Product Launches System monitoring and control with automated The HRD tests will leverage Illumina's procedures and guided maintenance routines through the Thermo Scientific Vanquish User TruSight™ Oncology 500 (TSO 500) content, Interface. For more information on the Thermo Scientific enabling the most comprehensive genomic Vanquish Neo UHPLC System, please visit: www.thermofisher.com/vanquishneo. For more profiling assays in a single workflow.This information on the Thermo Scientific PepMap Neo Columns, please visit strategic partnership builds on an initial http://www.thermofisher.com/lowflowHPLCc olumns. study conducted with Merck and About Thermo Fisher Scientific leverages Illumina's relationship with Myriad Thermo Fisher Scientific Inc. is the world leader Genetics to expand international access to the in serving science, with annual revenue exceeding $30 billion. proprietary technology in Myriad's FDA Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether approved myChoice® CDx companion our customers are accelerating life sciences research, solving complex analytical challenges, diagnostic test. improving patient diagnostics and therapies or increasing productivity in their laboratories, we Illumina will develop a new HRD CDx test for are here to support them. Our global team of the EU and the UK to aid in the identification of more than 80,000 colleagues delivers an ovarian cancer patients with positive HRD status unrivaled combination of innovative who are eligible for treatment with technologies, purchasing convenience and LYNPARZA® (olaparib), a first-in-class PARP pharmaceutical services through our industry- inhibitor, jointly developed and commercialized leading brands, including Thermo Scientific, by Merck and AstraZeneca. Applied Biosystems, Invitrogen, Fisher In addition, Illumina will develop and Scientific, Unity Lab Services and Patheon. commercialize a research use only (RUO) HRD assay that will be add-on content for the TSO 500 Illumina Partners with RUO panel. Illumina plans to launch this product globally, excluding the United States and Japan. Merck to Develop and \"With such great advances in precision medicine being made by companies such as Merck, it's Commercialize essential that patients who would benefit from LYNPARZA are identified,\" said Joydeep Companion Diagnostic Goswami, Chief Strategy and Corporate Development Officer of Illumina. \"By leveraging and Research Tests for our comprehensive genomic profiling family of products, TruSight™ Oncology, and the gold Use in Identifying Specific standard myChoice® HRD technology, Illumina aims to offer the best-in-class HRD assay that is Cancer Mutations broadly accessible. By harnessing the incredible medicines development expertise of Merck, Source: Illumina together we will be able to leverage the use of precision medicines to make a real difference for Illumina, Inc. and Merck (known as MSD patients.\" outside the United States and Canada) have \"HRD testing should be an essential component announced a partnership to develop and of clinical diagnosis as half of all newly diagnosed commercialize tests that identify genetic patients with advanced ovarian cancer have mutations used in the assessment of homologous HRD-positive tumors,\" said Dr. Eric H. Rubin, recombination deficiency (HRD). Patients whose senior vice president, early-stage development, tumors are HRD-positive may be eligible for clinical oncology, Merck Research Laboratories. targeted treatment by a class of precision medicines called PARP inhibitors. Microbioz India, September 2021 Edition | 62
Product Launches About Illumina \"Biomarker testing has rapidly enhanced our Illumina is improving human health by unlocking understanding of how PARP inhibition can help the power of the genome. Our focus on target a devastating disease, like ovarian cancer innovation has established us as the global leader and we are excited to partner with Illumina on in DNA sequencing and array-based the development of a distributed CDx HRD technologies, serving customers in the research, assay for the EU and UK.\" clinical and applied markets. Our products are This collaboration with Merck expands on used for applications in the life sciences, Illumina's solid history and broad portfolio of oncology, reproductive health, agriculture and oncology partnerships with industry leaders, with other emerging segments. the united goal of advancing cancer diagnostics and precision medicine. Gilson's New VERITY® About TruSight Oncology 500 1741 UV-VIS Detector - TSO 500 is a Research Use Only pan-cancer Specially Designed to assay that enables Comprehensive Genomic Profiling. Secure Semi-Preparative Designed to identify known and emerging tumor and Preparative HPLC biomarkers across 523 genes, TSO 500 utilizes both DNA and RNA from tumor samples to Applications identify key variants critical for cancer development and progression, such as small Source: Gilson UK DNA variants, fusions, and splice variants. In addition, the assay assesses key immune- oncology biomarkers, such as Tumor Mutational Burden (TMB) and Microsatellite Instability (MSI). Due to its comprehensive biomarker content, labs can consolidate multiple single gene or small panel workflows into a single assay, saving biopsy specimen and time. Based on the content of TSO 500, Illumina will be adding an in vitro diagnostic (IVD) test to the TSO product family. This comprehensive tumor profiling assay will have similar chemistry and analytics to TSO 500. About Myriad Genetics and Gilson has announced a new UV- myChoice® CDx VIS detector to its VERITY® line of purification systems. Myriad Genetics is a leading genetic testing and precision medicine company dedicated to The VERITY® 1741 UV-VIS Detector is specifically improving health and well being for all. Myriad's designed with the needs of semi-preparative and myChoice CDx companion diagnostic test is the preparative HPLC customers in mind. It relies on the first and only FDA-approved tumor test that power of UV-VIS with diode array detection (DAD) determines homologous recombination technology, like that found in Gilson's popular PLC deficiency status by detecting BRCA1 and Purification Systems. The VERITY 1741 Detector is BRCA2 (sequencing and large rearrangement) an ideal solution for purification applications in drug variants and assessing genomic instability using discovery, food supplements, natural products, and three critical biomarkers: loss of heterozygosity, biomolecular research. telomeric allelic imbalance and large-scale state transitions. It has been referred to as \"The most comprehensive Tumor test to determine HRD status in patients with ovarian cancer.\" Microbioz India, September 2021 Edition | 63
Product Launches HORIBA to showcase novel When controlled by Gilson's POCKIT Central PCR TRILUTION® LC Software to power up Gilson's VERITY® line of analyser at BEVA and Vets purification systems, the reliable VERITY 1741 Detector offers a North 200-800 nm scanning range and multiple different wavelength source: HORIBA Medical detection simultaneously, which can significantly increase purification Why wait for results? Vets can see for specificity. Spectra can also be themselves how easy it is to do in-house viewed in real-time, allowing PCR testing researchers to quickly identify co- eluting impurities or other HORIBA UK Limited will be showcasing its separation details. The extensive new benchtop POCKIT™ Central* in- range of path flow cells makes the house veterinary PCR analyser on Stand C3 detector highly versatile to a wide at the BEVA Congress, Birmingham, 4-7 September. array of compound concentrations HORIBA’s first live event this year will give visitors and purification schemes. the opportunity to see how easy it is to carry out in- house PCR Testing on the POCKIT Central. The The detector features a built-in simple “sample in, result out” process provides fast, counter for monitoring lamp life, accurate PCR testing in only in 85 mins for up to 8 which helps users avoid pathogens in one run. Ideally suited to veterinary interruptions and sample loss during practices, the POCKIT Central ensures confident a purification. The detector also uses diagnostic and case management decision making easy to replace long-lasting lamps without needing to wait for external laboratory and flow cells, resulting in less results. instrument downtime. Gilson's service experience with similar PLC detectors translate to minimizing the cost of ownership. The VERITY 1741 Detector is easy to use and maintain while providing extended detection power. About Gilson Gilson is a family-owned global manufacturer of sample management, purification, and extraction solutions for the life sciences industry. We help researchers advance the pace of discovery by creating easy-to-use lab devices that improve reproducibility and traceability. Since 1957, we've been developing innovative products, such as the first continuously adjustable-volume pipette, PIPETMAN®. By partnering closely with the scientific community, we have advanced our portfolio offerings, adding automated pipetting systems and chromatography instruments, plus intuitive software management capabilities. Backed by worldwide R&D, service, and support, Gilson strives to enable verifiable science and to make lab life easier for our customers. Microbioz India, September 2021 Edition | 64
Product Launches The POCKIT Central offers more than 190 PCR tests, including over 30 new ones, tailored to Equine, Small Animal and Farm practices, with specialist assays for Poultry and Aquaculture. Equine diagnostic tests include Theileria equi, Pseudomonas aeruginosa, Streptococcus equi, EHV, Taylorella equigenitalis and influenza, and other new tests include Lyme disease, Dirofilaria immitis, Neospora caninum, Mec A gene for MRSA and IBR. BEVA visitors will also be able to see HORIBA’s INTEGRA produce high-quality GripTips that LAQUAtwin Ca-11C waterproof, pocket ionised are only compatible with their own innovative calcium (iCa) meter for on-site monitoring of ionised pipetting products, so it has always been their top calcium, and HORIBA experts will be on hand to talk priority to be able to supply their customers with about the PC400 clinical chemistry analyser. pipette tips whenever needed. HORIBA UK will also participate in Vets North (Haydock Park Racecourse, 15-16 September) so vets To fully guarantee tip availability, INTEGRA of all specialities can see HORIBA’s accurate produce pipette tips in excess of market demand. diagnostic instruments and discuss their use with the When testing for SARS-CoV-2 increased this HORIBA Team. demand to unprecedented levels in early 2020, * available from HORIBA in selected countries in INTEGRA started to massively increase tip Europe production capacities. As a result, INTEGRA offers one of the very few pipettes today which INTEGRA guarantees your can provide a steady and reliable supply of pipette tips. lab a steady supply of high- If your lab has been facing tip shortages, we are honored to extend our tip pledge to you as well. quality pipette tips Contact us to see how INTEGRA pipettes can help make you more productive and precise. Source: Integra Biosciences AG Order your pipetting device with guaranteed tip supply today. I NTEGRA promise all their customers a consistent and reliable supply of pipette tips. How can they make this claim? Simple. Microbioz India, September 2021 Edition | 65
Microbioz India, September 2021 Edition | 66
Microbioz India, September 2021 Edition | 67
PUBLISHED ON: 25th September 2021 RNI NUMBER: UPENG/2017/73675 Microbioz India, September 2021 Edition | 68
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