Manufacturing process of nutricosmetics III

Nutritional Cosmetic Manufacturing www.egoteck.com Sarita Sangthong, Ph.D. 1

Powder mixer considerations 1. Batch size Some mixer designs may not achieve a full homogeneous mix when the volume is large or the mixing time is extended. 2. Mixing time The shorter the mixing time to achieve an homogeneous mix then the lower the costs will be and there will be less product degradation with sensitive materials. Look for efficiency in blending operations with gentle actions. 3. Power consumption Energy efficiency is a vital factor these days and not just the installed motor power but the actual power used in blending. 2 http://www.hosokawa-micron-bv.com/news-and-events/publications/ten-top-tips-when-selecting-mixers-for-powder-blending.html

Powder mixer considerations 4. Ease of discharge The discharge of a batch blender is one of the most critical functions and here it is necessary to ensure that the blender empties fully and smoothly with no residual 'heel'. Check the discharge opening size as many blended powder products can be a little sticky and have poor flow properties. 5. Internal surface Smooth internal surface of the mixer always make easier discharge. For foods and pharmaceuticals stainless steel vessels are common. 6. Ease of cleaning & cross contamination This is very important if the mixer is to be used for different products. The part of equipment should be smooth and less corner as possible to facilitate the ease of cleaning. 3 http://www.hosokawa-micron-bv.com/news-and-events/publications/ten-top-tips-when-selecting-mixers-for-powder-blending.html

Powder mixer considerations 7. Know your target result It is important to know a clear end result specification so that help in choosing the right mixer suited to your requirements. 8. Factory space More than the actual space for the mixer but any access requirements for loading and discharge and cleaning as well as ceiling height need to be considered. 9. System design The whole system of operation including the transportation from one process to another process of packaging is also to be considered. 4 http://www.hosokawa-micron-bv.com/news-and-events/publications/ten-top-tips-when-selecting-mixers-for-powder-blending.html

Powder mixing process Powder in the range of particle sizes (use the obtaining size or sieving to the require size) Adding into mixing vessel (manually or automatically) Mixing (by the suitable mixer) Spraying (optional for additional purposes) Discharging (into the receiving container) 5

Types of powder mixer • Tumble mixer • Ribbon mixer • Conical ribbon mixer V-shaped Blender Barrel Blender Double-cone Blender Bin Blender 6

Tumble mixer • Hollow vessel • Mixed up by slowly rotating Pros  Simple and cost effective  Various mixing vessel (tumble) shape Cons  Not suitable for segregated powder (wide range of particle size) Powder segregation 7

Tumble mixer • Basic blending or mixing process V-shaped Blender Barrel Blender Double-cone Blender Bin Blender 8

Tumble mixer V-shape blender (Rocky DEM Particle Simulator, 2016) https://www.youtube.com/watch?v=SOoOmhrPLdQ 9 (video from Rocky DEM Particle Simulator, 2016)

Tumble mixer V-shape blender (Rocky DEM Particle Simulator, 2016) https://www.youtube.com/watch?v=SOoOmhrPLdQ (video from Rocky DEM Particle Simulator, 2016) 10

Tumble mixer Double-cone blender (Inoxpa Group, 2017) https://www.youtube.com/watch?v=C1dTSgNuaeI&t=97s 11 (video from Inoxpa Group, 2017)

Tumble mixer Double-cone blender (Inoxpa Group, 2017) 1. Loading of powder ingredients 2. Mix thoroughly 3. Spaying of liquid ingredient 4. Discharging of finish product Double cone blender MBC INOXPA 12

Ribbon blender (Inoxpa Group, 2017) Pros • Applicable in wide rang of powder particle sizes • Applicable in various types of powder Cons  Hard to discharge and cleaning https://www.youtube.com/watch?v=61QHUrEJdSM 13

Conical ribbon mixer (HosokawaMicron, 2015) Pros  Very high mixing quality  Full batch discharge  Flexible to various powder particle size  Large size Cons Not suitable for sticky material Large area and high ceiling required Iron oxide pigment Fine granular sugar 14 (less than 20 microns) (400 microns)

Conical ribbon mixer • The mixing screw transports material up • Radial arm causes a continuous exchange of particles • Product moves to the center and drop under gravity • Cycle repeats 15

Powder mixing parameter Working Capacity (L) Typical RPM Typical Amount (Kg) 20-50 250 25–30 8-30 500 2000 22–28 80-150 12–18 200-300 8–12 800-1200 • Rotational velocity (rpm) is key blending parameter • Scale-up  as mass increases, blender rpm deGcureesass?e?s. 16

Mixing technology 3D Powder Mixer https://youtu.be/yZk96G6jNa8 (video from www.promector.fi) 17

Mixing technology Swing Powder Mixer - the turn-tilting motion - easy to operate - changeable mixing tanks - available in 3-100 L. capacity - constant mixing - quiet operation - efficient 3D trajectory - energy-saving - short mixing time - easy to clean www.promector.fi 18

Granule and pellet Granulator  Extruder  Spheronizer 19 https://www.youtube.com/watch?v=ZaOUXOcurWE

Pellet Spheronizer Friction disc The most common groove pattern is the square cross-hatched square design The processing surface is covered with a grid of truncated pyramids. http://spheronizer.com/html/spheronization.html 20

Tablet 21

Tablet coating (sugar coating and film coating) Spraying gun attached to mixing vessel Air drying Spraying Spraying Spraying Taizhou Jincheng Pharmaceutical Machinery Co.,Ltd 22

Capsule Empty capsule placing  Filling  Capping • Manual • Semi-automatic • Fully automatic 23

Capsule : Size 24 http://kinam.com/Lectures/363/3.Capsules%20Text.pdf

Capsule: Filling http://www.saintytec.com/benefits-dosator-capsule-filler-machines-powder-pellets-filling-applications/ https://www.youtube.com/watch?v=HoKjepJ4osU 25

Capsule Empty capsule placing  Filling  Capping • Manual • Semi-automatic • Fully automatic 26

Soft capsule Water Glycerin Gelatin 1. Mixing 2. Gel ribbon 3. Encapsulating 4. Capsule drying Example for softgel making: https://www.youtube.com/watch?v=vlz3g0xou2s 27

Soft capsule • Softgel die roll available in different shapes and sizes http://www.seekpart.com/product/Softgel-Die-Roll 28

Liquid filling capsule (CapsugelPTG, 2011) •Liquid filled into empty capsule •Sealing by microspray •Gentle heated for more secure sealing https://www.youtube.com/watch?v=ZGxIBelvLUA 29

Solution and suspension Filling techniques https://www.linkedin.com/pulse/basics- different-filling-technology-erald-breshani/ 30

Solution and suspension Filling techniques • Flash pasteurized • Heating to 180-220°C • Product is for a few minutes and heated and filled then cooled and filled at high temp at room temperature. • Beneficial to maintain • Inexpensive the flavor, color and • Appropriate for non- nutritional benefits of certain products such carbonated liquid as fruit juices • Shelf life 6-12 months • Affect to flavor, • Cold product filled in cold container nutrition and color • Suitable for fresh products • Short expiring date- 30 days https://www.linkedin.com/pulse/basics-different-filling-technology-erald-breshani/ 31

Primary packaging • Blister • Bag • Sachet • Bottle 32

Which technique should be used in your product!!! 33

Which one called double-cone mixer AC D B B 34

https://www.youtube.com/watch?v=SOoOmhrPLdQ https://www.youtube.com/watch?v=C1dTSgNuaeI&t=97s https://www.youtube.com/watch?v=tpt5VerLSsg https://youtu.be/yZk96G6jNa8 https://www.youtube.com/watch?v=ZaOUXOcurWE https://www.youtube.com/watch?v=w1pxsuO9i9o https://www.youtube.com/watch?v=pu9bvGlCxVc https://www.youtube.com/watch?v=vlz3g0xou2s 35