The preformulation of NC product Active ingredient(s): Standardization Analytical method depends on; - Analyzing purpose; required information - Form of sample_ solid or liquid - Thermal sensitivity of sample - Volatility of sample 51
The preformulation of NC product Active ingredient(s): Standardization Particle size and size distribution • Sifting method; Sieving Used for d?ry sample or pow?der forestry-suppliers.com 52
The preformulation of NC product Active ingredient(s): Standardization Particle size and size distribution Characteristic Analytical methods, e.g., • Microscope • Transmission electron microscope (TEM) • Scanning electron microscope (SEM) Microscope http://slideplayer.com/slide/8118544/ 53 http://www.slh.wisc.edu/wohl/wohl works/analysis_inorganic/37.dot
The preformulation of NC product Active ingredient(s): Standardization Particle size and size distribution Frequency Particle size distribution Diameter (nm) Chiacchia et al. J. Mater. Chem. B, 2015, 3, 9053-9059 54
The preformulation of NC product Active ingredient(s): Standardization Particle size and size distribution Methods Measuring range Sieving 5-125,000 µm Laser light scattering 1-1,000 µm Optical microscopy 0.25-50 µm Electron microscopy 0.005-1 µm 55
The preformulation of NC product Active ingredient(s): Standardization Particle size and size distribution Impact on; • Stability of product • Product’s appearance • Suspendability • Dissolution rate • Absorption 56
The preformulation of NC product Active ingredient(s): Standardization Fingerprint; Chromatography • Thin-layer chromatography • Liquid chromatography TLC fingerprint of LC–MS fingerprints of carotenoids in seaweeds flavonoids in plant extract Mikami K, Hosokawa M - Int J Mol Sci (2013) 57 J App Res Med Aromatic Plants (2014 )
The preformulation of NC product Active ingredient(s): Standardization Fingerprint; Chromatography • Gas chromatography (GC); Volatile compounds Chromatographic profile of lipid classes of krill oil (KO) Castro-Gómez et al., 2015 (Food Anal. Methods) 58
The preformulation of NC product Active ingredient(s): Standardization Fingerprint; Chromatography • Fourier-transform infrared spectroscopy; functional groups FTIR spectra of cross-linked alginate, collagen, and the mixture 59 Kim & Kim, J Materials Chemist B, 2013
The preformulation of NC product Active ingredient(s): Standardization Fingerprint • Protein molecular weight and pattern SDS-PAGE analysis of jellyfish collagens. Addad et al. (2011) Mar. Drugs, 9(6), 967-983 60
The preformulation of NC product Active ingredient(s): Standardization Impact on; • Quality control of product • Pharmacological activity of product • Accurate dose of active ingredient 61
The preformulation of NC product Active ingredient(s): Standardization Where to find ? 62
63 http://www.viscofan-bioengineering.com/files/docs/COLL instant-collagen-hydrolysate/PDCOLLinstantHydrolysate.pdf
64 http://www.viscofan-bioengineering.com/files/docs/COLL instant-collagen-hydrolysate/PDCOLLinstantHydrolysate.pdf
The preformulation of NC product Active ingredient (s) NC product dosage form 65
The preformulation of NC product (example) Next step >> Krill oil product Omega-3 ??? Eicosapentaenoic acid (EPA) Docosahexaenoic acid (DHA) Astaxanthin Krill oil with the maximum efficacy 66
Introduction to NC dosage form Route of administration Oral administration 67
Introduction to NC dosage form Dosage form design (more details in NC formulation) http://www.shefinds.com/are-skincare-drinks-and- nutricosmetics-the-next-big-thing-in-beauty/ https://www.ebay.com/sch/Meiji-Vitamins-Dietary-Supplements/180959/bn_25283718/i.html?_fsrp=1&_trksid=p2047675.m4097.l9147 68
More of Dosage Form Design in the Next topic NC Formulation https://lifehacker.com/treat-failure-like-a-scientist 69
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