what is the difference between integral and peripheral membrane proteins

List of Membrane Proteins Membrane proteins include transmembrane proteins that span across the membrane, Monotypic/peripheral membrane proteins that attached to the lipid bilayer or other integral proteins and peptide. The reason that membrane proteins studies are extremely important is that they are targets of over 50% of all modern drugs. It is estimated that 20-30% of all genes in most genomes encode membrane proteins. However, such proteins are inherently difficult to purify and characterize. The production of membrane protein is an urgent issue to handle with and optimize. Backed by a team with extensive experience in membrane protein production, Creative Biostructure can express and purify membrane proteins that are currently unavailable in the market (e.g., GPCR, ion channels, transporters, enzymes and viral targets). Following is a list of membrane protein production provided by Creative Biostructure. Transmembrane Protein Production 5-Lipoxygenase-Activating Hypoxia-induced Proteins Aldehyde Dehydrogenases Protein Immunoglobulins Ammonia and Urea transporters ABC Transporters Insulin receptor FMN-linked Oxidoreductases ACBP Integrins Leucine Rich Repeat (LRR)-Containing Amyloid beta (A4) Ion channel Transmembrane Proteins Bcl-2 Inhibitors MAPEG Leukotriene C4 synthase BNIPs MFS Lysosome-associated membrane CAAX protease MinK Family glycoprotein Cytochromes P450 MPPs Major Intrinsic Protein (MIP)/FNT E-NPPs Peptidase AD superfamily EPHA1 Peptidase Family M48 Microsomal prostaglandin E synthase EPHA2 Peptidase MA N-(deoxy)ribosyltransferase-like Membrane EPHA3 Protein Jagged Proteins EPHA4 Receptor-type Kinases Neutral/alkaline Ceramidases Fatty Acid Desaturases SNARE Complex Oligosaccharyl Transferase Gamma secretase Sulfatases Pentameric Ligand-gated Ion Channels Glucose transporter TNF receptor Rhodopsin-like receptors and pumps Glycophorins Transmembrane Proteins 14 Single-helix ATPase Regulators GPCR Transporter Squalene/ phytoene Synthase HER2/ErbB2 TROBP Stearoyl -CoA desaturase 1 HER3/ErbB3 VEGF receptors Stannin (SNN) Membrane Proteins HER4/ErbB4 T-cell Surface Glycoprotein CD3 Zeta HSD-11β Chain Tetratricopeptide repeat (TPR) Alpha- Helical Repeat Proteins

Transmembrane Proteins with NAD(P)- binding Rossmann-fold Domains Monotypic/Peripheral Protein Production Alpha/Beta-Hydrolase FYVE/PHD Zinc Finger Phosphatidylinositol 3-/4-Kinase Annexins Protein PLC-like Phosphodiesterase Bet V1-Like Protein Galactose-Binding Domain- Phosphotyrosine Protein Phosphatases II C1 Domain-Containing Like Protein P-Loop Containing Nucleoside Protein Glycolipid Transfer Protein Triphosphate Hydrolase C2 Domain-containing Immunoglobulin-Like Protein kinase superfamily Protein Superfamily (E Set) Protein PX Domain-Containing Protein CoA-Dependent Lipocalin Saposin Acyltransferases Lipoxygenase Synuclein CRAL-TRIO Domain- PGBD superfamily Transcriptional factor tubby Containing PH Domain-Like Protein Protein DNase I-like protein Fibrinogen Membrane Protein Peptides Production Amyloid Beta-sheet Peptide Fragments of Peptide fragments of water-soluble proteins Peptides Transmembrane Protein Membrane Anchor Helices of Peripheral Proteins Our scientists will assist you in all project stages evaluation, planning and execution. Each project is tailored to the customer’s specifications of scale, purity, analytical characterization and activity. We help our customers plan their projects in the most cost efficient manner. Please feel free to contact us for a detailed quote. References 1. Johnson J., Cornell B. (1999). Amphitropic proteins: regulation by reversible membrane interactions. Mol. Membr. Biol. 16: 217-235

2. Overington J., Al-Lazikani B., Hopkins A. (2006). How many drug targets are there? Nat. Rev. Drug. Discov. 5: 993-996 Related Sections Services: • Cell-Based Membrane Protein Expression Services • Cell-free Membrane Protein Expression • VLP Construction