MAINTAINING GOOD HEALTH | 49
50 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 51
52 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 53
54 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 55
56 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 57
58 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 59
60 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 61
62 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 63
64 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 65
66 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 67
68 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 69
70 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 71
72 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 73
74 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 75
76 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 77
78 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 79
80 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 81
82 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 83
84 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 85
86 | B COMPLEX + MINERAL
MAINTAINING GOOD HEALTH | 87
References 1. https://www.cdc.gov/ncbddd/folicacid/about.html 2. Finkelstein JL, Layden AJ, Stover PJ. Vitamin B-12 and Perinatal Health. Adv Nutr. 2015;6(5):552-563. Published 2015 Sep 15. doi:10.3945/an.115.008201 3. Agarwal R. Vitamin B₁₂ deficiency & cognitive impairment in elderly popula- tion. Indian J Med Res. 2011;134(4):410-412. 4. Kjeldby IK, Fosnes GS, Ligaarden SC, Farup PG. Vitamin B6 deficiency and diseases in elderly people--a study in nursing homes. BMC Geriatr. 2013;13:13. Pub- lished 2013 Feb 8. doi:10.1186/1471-2318-13-13 5. Clarke R, Grimley Evans J, Schneede J, Nexo E, Bates C, Fletcher A, Pren- tice A, Johnston C, Ueland PM, Refsum H, Sherliker P, Birks J, Whitlock G, Breeze E, Scott JM. Vitamin B12 and folate deficiency in later life. Age Ageing. 2004 Jan;33(1):34-41. 6. Sandra P. Arévalo, Tammy M. Scott, Luis M. Falcón & Katherine L. Tuck- er (2019) Vitamin B-6 and depressive symptomatology, over time, in older Latino adults, Nutritional Neuroscience, 22:9, 625-636 7. Reinstatler L, Qi YP, Williamson RS, Garn JV, Oakley GP Jr. Association of biochemical B₁₂ deficiency with metformin therapy and vitamin B₁₂ supplements: the National Health and Nutrition Examination Survey, 1999-2006. Diabetes Care. 2012;35(2):327-333. doi:10.2337/dc11-1582 8. Wilson SM, Bivins BN, Russell KA, Bailey LB. Oral contraceptive use: impact on folate, vitamin B₆, and vitamin B₁₂ status. Nutr Rev. 2011 Oct;69(10):572-83. 9. Kim KM, Kim MJ, Song SW, Cho DY, Park KC, Yang SW, Kim YS, Kim KS. Efficacy and Safety of “URSA Complex” in Subjects with Physical Fatigue: A Mul- ticenter, Randomized, Double-blind, Placebo-controlled Trial. Chin Med J (Engl). 2016 Jan 20;129(2):129-34. 10. Suzuki M, Itokawa Y. Effects of thiamine supplementation on exercise-in- duced fatigue. Metab Brain Dis. 1996 Mar;11(1):95-106. 11. Alaei Shahmiri F, Soares MJ, Zhao Y, Sherriff J. High-dose thiamine supple- mentation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial. Eur J Nutr. 2013 Oct;52(7):1821-4. 12. González-Ortiz M, Martínez-Abundis E, Robles-Cervantes JA, Ramírez- Ramírez V, Ramos-Zavala MG. Effect of thiamine administration on metabolic pro- file, cytokines and inflammatory markers in drug-naïve patients with type 2 diabetes. Eur J Nutr. 2011 Mar;50(2):145-9 13. Riaz S, Skinner V, Srai SK. Effect of high dose thiamine on the levels of uri- nary protein biomarkers in diabetes mellitus type 2. J Pharm Biomed Anal. 2011 Mar 25;54(4):817-25. 14. Butterworth RF, Besnard AM. Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer’s disease. Metab Brain Dis. 1990 Dec;5(4):179-84.
15. Benton D, Griffiths R, Haller J. Thiamine supplementation mood and cogni- tive functioning. Psychopharmacology (Berl). 1997 Jan;129(1):66-71. 16. Rommer PS, Fuchs D, Leblhuber F, Schroth R, Greilberger M, Tafeit E, Grei- lberger J. Lowered Levels of Carbonyl Proteins after Vitamin B Supplementation in Patients with Mild Cognitive Impairment and Alzheimer’s Disease. Neurodegener Dis. 2016;16(3-4):284-9. 17. Lonsdale D, Shamberger RJ, Audhya T. Treatment of autism spectrum chil- dren with thiamine tetrahydrofurfuryl disulfide: a pilot study. Neuro Endocrinol Lett. 2002 Aug;23(4):303-8. PMID: 12195231. 18. Botez MI, Botez T, Ross-Chouinard A, Lalonde R. Thiamine and folate treat- ment of chronic epileptic patients: a controlled study with the Wechsler IQ scale. Epilepsy Res. 1993 Oct;16(2):157-63. 19. Bubko I, Gruber BM, Anuszewska EL. Rola tiaminy w chorobach neurode- generacyjnych [The role of thiamine in neurodegenerative diseases]. Postepy Hig Med Dosw (Online). 2015 Sep 21;69:1096-106. Polish. PMID: 26400895. 20. DiNicolantonio JJ, Niazi AK, Lavie CJ, O’Keefe JH, Ventura HO. Thiamine supplementation for the treatment of heart failure: a review of the literature. Congest Heart Fail. 2013 Jul-Aug;19(4):214-22. 21. Schoenenberger AW, Schoenenberger-Berzins R, der Maur CA, Suter PM, Vergopoulos A, Erne P. Thiamine supplementation in symptomatic chronic heart failure: a randomized, double-blind, placebo-controlled, cross-over pilot study. Clin Res Cardiol. 2012 Mar;101(3):159-64. 22. www.aaojournal.org/article/S0161-6420(00)00626-6/pdf 23. Abdollahifard S, Rahmanian Koshkaki A, Moazamiyanfar R. The effects of vitamin B1 on ameliorating the premenstrual syndrome symptoms. Glob J Health Sci. 2014 Jul 29;6(6):144-53. 24. Hosseinlou A, Alinejad V, Alinejad M, Aghakhani N. The effects of fish oil capsules and vitamin B1 tablets on duration and severity of dysmenorrhea in students of high school in Urmia-Iran. Glob J Health Sci. 2014 Sep 18;6(7 Spec No):124-9. 25. Boehnke C, Reuter U, Flach U, Schuh-Hofer S, Einhäupl KM, Arnold G. High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. Eur J Neurol. 2004 Jul;11(7):475-7. 26. Thompson DF, Saluja HS. Prophylaxis of migraine headaches with riboflavin: A systematic review. J Clin Pharm Ther. 2017 Aug;42(4):394-403. 27. Namazi N, Heshmati J, Tarighat-Esfanjani A. Supplementation with Ribofla- vin (Vitamin B2) for Migraine Prophylaxis in Adults and Children: A Review. Int J Vitam Nutr Res. 2015;85(1-2):79-87. 28. Jacques PF, Taylor A, Moeller S, Hankinson SE, Rogers G, Tung W, Ludovico J, Willett WC, Chylack LT Jr. Long-term nutrient intake and 5-year change in nucle- ar lens opacities. Arch Ophthalmol. 2005 Apr;123(4):517-26. 29. Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced col- lagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003
May;135(5):620-7. 30. Naghashpour M, Amani R, Nutr R, Nematpour S, Haghighizadeh MH. Ribo- flavin status and its association with serum hs-CRP levels among clinical nurses with depression. J Am Coll Nutr. 2011 Oct;30(5):340-7. 31. Murakami K, Miyake Y, Sasaki S, Tanaka K, Arakawa M. Dietary folate, ribo- flavin, vitamin B-6, and vitamin B-12 and depressive symptoms in early adolescence: the Ryukyus Child Health Study. Psychosom Med. 2010 Oct;72(8):763-8. 32. Miyake Y, Sasaki S, Tanaka K, Yokoyama T, Ohya Y, Fukushima W, Saito K, Ohfuji S, Kiyohara C, Hirota Y; Osaka Maternal and Child Health Study Group. Dietary folate and vitamins B12, B6, and B2 intake and the risk of postpartum de- pression in Japan: the Osaka Maternal and Child Health Study. J Affect Disord. 2006 Nov;96(1-2):133-8. 33. Yazdanpanah N, Zillikens MC, Rivadeneira F, de Jong R, Lindemans J, Uitter- linden AG, Pols HA, van Meurs JB. Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: the Rotterdam study. Bone. 2007 Dec;41(6):987- 94. 34. Chaves Neto AH, Yano CL, Paredes-Gamero EJ, Machado D, Justo GZ, Pep- pelenbosch MP, Ferreira CV. Riboflavin and photoproducts in MC3T3-E1 differenti- ation. Toxicol In Vitro. 2010 Oct;24(7):1911-9. 35. Chan P, Huang TY, Chen YJ, Huang WP, Liu YC. Randomized, double-blind, placebo-controlled study of the safety and efficacy of vitamin B complex in the treat- ment of nocturnal leg cramps in elderly patients with hypertension. J Clin Pharma- col. 1998 Dec;38(12):1151-4. PMID: 11301568. 36. McKenney J. New Perspectives on the Use of Niacin in the Treatment of Lipid Disorders. Arch Intern Med. 2004;164(7):697–705. 37. Morris MC, Evans DA, Bienias JL, Scherr PA, Tangney CC, Hebert LE, Bennett DA, Wilson RS, Aggarwal N. Dietary niacin and the risk of incident Alz- heimer’s disease and of cognitive decline. J Neurol Neurosurg Psychiatry. 2004 Aug;75(8):1093-9. 38. Wang W, Liang B. Case report of mental disorder induced by niacin deficien- cy. Shanghai Arch Psychiatry. 2012 Dec;24(6):352-4. 39. Park SM, Li T, Wu S, Li WQ, Weinstock M, Qureshi AA, Cho E. Niacin intake and risk of skin cancer in US women and men. Int J Cancer. 2017 May 1;140(9):2023-2031. 40. Chen AC, Martin AJ, Choy B, Fernández-Peñas P, Dalziell RA, McKenzie CA, Scolyer RA, Dhillon HM, Vardy JL, Kricker A, St George G, Chinniah N, Halliday GM, Damian DL. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention. N Engl J Med. 2015 Oct 22;373(17):1618-26. 41. Niren NM, Torok HM. The Nicomide Improvement in Clinical Outcomes Study (NICOS): results of an 8-week trial. Cutis 2006; 77(Suppl): 17–28. 42. Shalita AR, Falcon R, Olansky A, Iannotta P, Akhavan A, Day D, Janiga A, Singri P, Kallal JE. Inflammatory acne management with a novel prescription dietary supplement. J Drugs Dermatol. 2012 Dec;11(12):1428-33. PMID: 23377512.
43. Jonas WB, Rapoza CP, Blair WF. The effect of niacinamide on osteoarthritis: a pilot study. Inflamm Res. 1996 Jul;45(7):330-4. doi: 10.1007/BF02252945. PMID: 8841834. 44. Yang M, Moclair B, Hatcher V, et al. A randomized, double-blind, place- bo-controlled study of a novel pantothenic Acid-based dietary supplement in sub- jects with mild to moderate facial acne. Dermatol Ther (Heidelb). 2014;4(1):93-101. doi:10.1007/s13555-014-0052-3 45. Rumberger JA, Napolitano J, Azumano I, Kamiya T, Evans M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-den- sity lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation. Nutr Res. 2011 Aug;31(8):608-15. 46. Naruta E, Buko V. Hypolipidemic effect of pantothenic acid derivatives in mice with hypothalamic obesity induced by aurothioglucose. Exp Toxicol Pathol. 2001 Oct;53(5):393-8. 47. Hvas AM, Juul S, Bech P, Nexø E. Vitamin B6 level is associated with symp- toms of depression. Psychother Psychosom. 2004 Nov-Dec;73(6):340-3. 48. Skarupski KA, Tangney C, Li H, Ouyang B, Evans DA, Morris MC. Longitu- dinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time. Am J Clin Nutr. 2010 Aug;92(2):330-5. 49. Merete C, Falcon LM, Tucker KL. Vitamin B6 is associated with depressive symptomatology in Massachusetts elders. J Am Coll Nutr. 2008 Jun;27(3):421-7. 50. Douaud G, Refsum H, de Jager CA, Jacoby R, Nichols TE, Smith SM, Smith AD. Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treat- ment. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9523-8. 51. Spinneker A, Sola R, Lemmen V, Castillo MJ, Pietrzik K, González-Gross M. Vitamin B6 status, deficiency and its consequences--an overview. Nutr Hosp. 2007 Jan-Feb;22(1):7-24. PMID: 17260529. 52. Hisano M, Suzuki R, Sago H, Murashima A, Yamaguchi K. Vitamin B6 defi- ciency and anemia in pregnancy. Eur J Clin Nutr. 2010 Feb;64(2):221-3. 53. Yasuda H, Fujiwara N, Ishizaki Y, Komatsu N. Anemia attributed to vi- tamin B6 deficiency in post-pancreaticoduodenectomy patients. Pancreatology. 2015;15(1):81-3. doi:10.1016/j.pan.2014.12.001 54. Kashanian M, Mazinani R, Jalalmanesh S. Pyridoxine (vitamin B6) therapy for premenstrual syndrome. Int J Gynaecol Obstet. 2007;96(1):43-4. 55. Doll H, Brown S, Thurston A, Vessey M. Pyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trial. J R Coll Gen Pract. 1989 Sep;39(326):364-8. PMID: 2558186; PMCID: PMC1711872. 56. De Souza MC, Walker AF, Robinson PA, Bolland K. A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, cross- over study. J Womens Health Gend Based Med. 2000 Mar;9(2):131-9. 57. Sahakian V, Rouse D, Sipes S, Rose N, Niebyl J. Vitamin B6 is effective therapy
for nausea and vomiting of pregnancy: a randomized, double-blind placebo-con- trolled study. Obstet Gynecol. 1991;78(1):33-6. 58. Vutyavanich T, Wongtra-ngan S, Ruangsri R. Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol. 1995 Sep;173(3 Pt 1):881-4. 59. Lin PT, Cheng CH, Liaw YP, Lee BJ, Lee TW, Huang YC. Low pyridoxal 5’-phosphate is associated with increased risk of coronary artery disease. Nutrition. 2006 Nov-Dec;22(11-12):1146-51. 60. Vermeulen EG, Stehouwer CD, Twisk JW, van den Berg M, de Jong SC, Mack- aay AJ, van Campen CM, Visser FC, Jakobs CA, Bulterjis EJ, Rauwerda JA. Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: a randomised, placebo-controlled trial. Lancet. 2000 Feb 12;355(9203):517-22. 61. Christen WG, Glynn RJ, Chew EY, Albert CM, Manson JE. Folic acid, pyri- doxine, and cyanocobalamin combination treatment and age-related macular degen- eration in women: the Women’s Antioxidant and Folic Acid Cardiovascular Study. Arch Intern Med. 2009;169(4):335-341. doi:10.1001/archinternmed.2008.574 62. Sofi F, Marcucci R, Bolli P, Giambene B, Sodi A, Fedi S, Menchini U, Gensi- ni GF, Abbate R, Prisco D. Low vitamin B6 and folic acid levels are associated with retinal vein occlusion independently of homocysteine levels. Atherosclerosis. 2008 May;198(1):223-7. 63. Huang SC, Wei JC, Wu DJ, Huang YC. Vitamin B(6) supplementation im- proves pro-inflammatory responses in patients with rheumatoid arthritis. Eur J Clin Nutr. 2010 Sep;64(9):1007-13. 64. Trüeb RM. Serum Biotin Levels in Women Complaining of Hair Loss. Int J Trichology. 2016;8(2):73-77. doi:10.4103/0974-7753.188040 65. Ablon G, Dayan S. A Randomized, Double-blind, Placebo-controlled, Multi-center, Extension Trial Evaluating the Efficacy of a New Oral Supplement in Women with Self-perceived Thinning Hair. J Clin Aesthet Dermatol. 2015 Dec;8(12):15-21. 66. Floersheim GL. Behandlung brüchiger Fingernägel mit Biotin [Treatment of brittle fingernails with biotin]. Z Hautkr. 1989 Jan 15;64(1):41-8. German. PMID: 2648686. 67. Hochman LG, Scher RK, Meyerson MS. Brittle nails: response to daily biotin supplementation. Cutis. 1993 Apr;51(4):303-5. PMID: 8477615. 68. Mock DM. Skin manifestations of biotin deficiency. Semin Dermatol. 1991 Dec;10(4):296-302. PMID: 1764357. 69. Zempleni J, Hassan YI, Wijeratne SS. Biotin and biotinidase deficiency. Ex- pert Rev Endocrinol Metab. 2008;3(6):715-724. doi:10.1586/17446651.3.6.715 70. Wolf B. The neurology of biotinidase deficiency. Mol Genet Metab. 2011 Sep- Oct;104(1-2):27-34. 71. Sedel F, Bernard D, Mock DM, Tourbah A. Targeting demyelination and vir- tual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis.
Neuropharmacology. 2016 Nov;110(Pt B):644-653. 72. Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, Gout O, Lyon-Caen O, Tourbah A. High doses of biotin in chronic progressive mul- tiple sclerosis: a pilot study. Mult Scler Relat Disord. 2015 Mar;4(2):159-69. 73. Tourbah A, Lebrun-Frenay C, Edan G, et al. MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, place- bo-controlled study. Mult Scler. 2016;22(13):1719-1731. 74. Cowan MJ, Wara DW, Packman S, Ammann AJ, Yoshino M, Sweetman L, Ny- han W. Multiple biotin-dependent carboxylase deficiencies associated with defects in T-cell and B-cell immunity. Lancet. 1979 Jul 21;2(8134):115-8. 75. Masaru MAEBASHI,Yoshio MAKINO,Yuji FURUKAWA,Kosaku OHINATA, Shuichi KIMURA, Takao SATO, Therapeutic Evaluation of the Effect of Biotin on Hyperglycemia in Patients with Non-Insulin Dependent Diabetes Mellitus, J. Clin. Biochem. Nutr., 14, 211-218, 1993. 76. Báez-Saldaña A, Zendejas-Ruiz I, Revilla-Monsalve C, Islas-Andrade S, Cárdenas A, Rojas-Ochoa A, Vilches A, Fernandez-Mejia C. Effects of biotin on pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and markers for glucose and lipid homeostasis in type 2 diabetic patients and nondiabet- ic subjects. Am J Clin Nutr. 2004 Feb;79(2):238-43. 77. Koutsikos D, Agroyannis B, Tzanatos-Exarchou H. Biotin for diabetic periph- eral neuropathy. Biomed Pharmacother. 1990;44(10):511-4. 78. Kothapalli N, Sarath G, Zempleni J. Biotinylation of K12 in histone H4 de- creases in response to DNA double-strand breaks in human JAr choriocarcinoma cells. J Nutr. 2005 Oct;135(10):2337-42. 79. Camporeale G, Giordano E, Rendina R, Zempleni J, Eissenberg JC. Drosoph- ila melanogaster holocarboxylase synthetase is a chromosomal protein required for normal histone biotinylation, gene transcription patterns, lifespan, and heat toler- ance. J Nutr. 2006 Nov;136(11):2735-42. 80. Wilson RD; GENETICS COMMITTEE; MOTHERISK. Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other con- genital anomalies. J Obstet Gynaecol Can. 2007 Dec;29(12):1003-1013. 81. Jang S, Han JW, Shin J, et al. Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment. Psychiatry Investig. 2019;16(7):532-538. 82. Ma F, Li Q, Zhou X, Zhao J, Song A, Li W, Liu H, Xu W, Huang G. Effects of folic acid supplementation on cognitive function and Aβ-related biomarkers in mild cognitive impairment: a randomized controlled trial. Eur J Nutr. 2019 Feb;58(1):345- 356. 83. Roberts E, Carter B, Young AH. Caveat emptor: Folate in unipolar depres- sive illness, a systematic review and meta-analysis. Journal of Psychopharmacology. 2018;32(4):377-384. 84. Li Y, Huang T, Zheng Y, Muka T, Troup J, Hu FB. Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta-Analysis of Randomized Con-
trolled Trials. J Am Heart Assoc. 2016 Aug 15;5(8):e003768. 85. Wang WW, Wang XS, Zhang ZR, He JC, Xie CL. A Meta-Analysis of Folic Acid in Combination with Anti-Hypertension Drugs in Patients with Hypertension and Hyperhomocysteinemia. Front Pharmacol. 2017;8:585. Published 2017 Aug 31. doi:10.3389/fphar.2017.00585 86. Yi X, Zhou Y, Jiang D, Li X, Guo Y, Jiang X. Efficacy of folic acid supplemen- tation on endothelial function and plasma homocysteine concentration in coronary artery disease: A meta-analysis of randomized controlled trials. Exp Ther Med. 2014;7(5):1100-1110. 87. Giovannucci E, Stampfer MJ, Colditz GA, Hunter DJ, Fuchs C, Rosner BA, Speizer FE, Willett WC. Multivitamin use, folate, and colon cancer in women in the Nurses’ Health Study. Annals of internal medicine. 1998 Oct 1;129(7):517-24. 88. Zhang S, Hunter DJ, Hankinson SE, Giovannucci EL, Rosner BA, Colditz GA, Speizer FE, Willett WC. A prospective study of folate intake and the risk of breast cancer. JAMA. 1999 May 5;281(17):1632-7. 89. Larsson SC, Giovannucci E, Wolk A. Folate and risk of breast cancer: a me- ta-analysis. Journal of the National Cancer Institute. 2007 Jan 3;99(1):64-76. 90. Wong WY, Merkus HM, Thomas CM, Menkveld R, Zielhuis GA, Stee- gers-Theunissen RP. Effects of folic acid and zinc sulfate on male factor subfer- tility: a double-blind, randomized, placebo-controlled trial. Fertil Steril. 2002 Mar;77(3):491-8. 91. Young SS, Eskenazi B, Marchetti FM, Block G, Wyrobek AJ. The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men. Hum Reprod. 2008 May;23(5):1014-22. 92. O’Leary F, Samman S. Vitamin B12 in health and disease. Nutrients. 2010;2(3):299-316. doi:10.3390/nu2030299 93. Molloy AM, Kirke PN, Brody LC, Scott JM, Mills JL. Effects of folate and vita- min B12 deficiencies during pregnancy on fetal, infant, and child development. Food Nutr Bull. 2008 Jun;29(2 Suppl):S101-11; discussion S112-5. 94. Molloy AM, Kirke PN, Troendle JF, et al. Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect preva- lence and no folic Acid fortification. Pediatrics. 2009;123(3):917-923. doi:10.1542/ peds.2008-1173 95. Tucker KL, Hannan MT, Qiao N, Jacques PF, Selhub J, Cupples LA, Kiel DP. Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteopo- rosis Study. J Bone Miner Res. 2005 Jan;20(1):152-8. 96. Dhonukshe-Rutten RA, Lips M, de Jong N, Chin A Paw MJ, Hiddink GJ, van Dusseldorp M, De Groot LC, van Staveren WA. Vitamin B-12 status is associated with bone mineral content and bone mineral density in frail elderly women but not in men. J Nutr. 2003 Mar;133(3):801-7. 97. Stone KL, Bauer DC, Sellmeyer D, Cummings SR. Low serum vitamin B-12 levels are associated with increased hip bone loss in older women: a prospective study. J Clin Endocrinol Metab. 2004 Mar;89(3):1217-21.
98. Christen WG, Glynn RJ, Chew EY, Albert CM, Manson JE. Folic acid, pyri- doxine, and cyanocobalamin combination treatment and age-related macular degen- eration in women: the Women’s Antioxidant and Folic Acid Cardiovascular Study. Arch Intern Med. 2009;169(4):335-341. doi:10.1001/archinternmed.2008.574 99. Syed EU, Wasay M, Awan S. Vitamin B12 supplementation in treating major depressive disorder: a randomized controlled trial. Open Neurol J. 2013;7:44-48. Published 2013 Nov 15. 100. Penninx BW, Guralnik JM, Ferrucci L, Fried LP, Allen RH, Stabler SP. Vita- min B(12) deficiency and depression in physically disabled older women: epidemi- ologic evidence from the Women’s Health and Aging Study. Am J Psychiatry. 2000 May;157(5):715-21. 101. Oulhaj A, Jernerén F, Refsum H, Smith AD, de Jager CA. Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cogni- tive Impairment. J Alzheimers Dis. 2016;50(2):547-557. 102. Köbe T, Witte AV, Schnelle A, Grittner U, Tesky VA, Pantel J, Schuchardt JP, Hahn A, Bohlken J, Rujescu D, Flöel A. Vitamin B-12 concentration, memory per- formance, and hippocampal structure in patients with mild cognitive impairment. Am J Clin Nutr. 2016 Apr;103(4):1045-54. 103. Markišić M, Pavlović AM, Pavlović DM. The Impact of Homocysteine, Vita- min B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke. Biomed Res Int. 2017;2017:5489057. doi:10.1155/2017/5489057 104. Brescoll J, Daveluy S. A review of vitamin B12 in dermatology. Am J Clin Dermatol. 2015 Feb;16(1):27-33. 105. Noppakun N, Swasdikul D. Reversible hyperpigmentation of skin and nails with white hair due to vitamin B12 deficiency. Arch Dermatol. 1986 Aug;122(8):896- 9. PMID: 3740873.
Search