K2+D3 for Covid-19 Eng

CONTENT01 Vitamin D3 and your immune system 05 Can taking Vitamin D3 protect against COVID-19? 10 Summary of vitamin D3 against Covid-19? 11 Vitamin K2 against COVID-19?



2 | vitamin D and your immune system

vitamin D and your immune system | 3

4 | vitamin D and your immune system

Can taking Vitamin D3 protect against COVID-19? | 5

6 | Can taking Vitamin D3 protect against COVID-19?

Can taking Vitamin D3 protect against COVID-19? | 7

8 | Can taking Vitamin D3 protect against COVID-19?

Can taking Vitamin D3 protect against COVID-19? | 9

10 | Summary of vitamin D3 against Covid-19?



12 | vitamin K2 against COVID-19?

vitamin K2 against COVID-19? | 13

14 | vitamin K2 against COVID-19?

References 1. Maghbooli Z, Sahraian MA, Ebrahimi M, Pazoki M, Kafan S, Tabriz HM, et al. (2020) Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL re- duced risk for adverse clinical outcomes in patients with COVID-19 infection. PLoS ONE 15(9): e0239799. 2. Bivona G, Agnello L, Ciaccio M. The immunological implication of the new vitamin D metabolism. Cent Eur J Immunol. 2018;43(3):331-334. 3. Di Rosa M, Malaguarnera M, Nicoletti F, Malaguarnera L. Vitamin D3: a helpful immuno-modulator. Immunology. 2011;134(2):123-139. doi:10.1111/j.1365- 2567.2011.03482.x 4. Hejazi ME, Modarresi-Ghazani F, Entezari-Maleki T. A review of Vitamin D effects on common respiratory diseases: Asthma, chronic obstructive pulmonary disease, and tuberculosis. J Res Pharm Pract. 2016;5(1):7-15. doi:10.4103/2279- 042X.176542 5. Hughes DA, Norton R. Vitamin D and respiratory health. Clin Exp Immunol. 2009;158(1):20-25. 6. Zosky GR, Berry LJ, Elliot JG, James AL, Gorman S, Hart PH. Vitamin D deficiency causes deficits in lung function and alters lung structure. Am J Respir Crit Care Med. 2011 May 15;183(10):1336-43. 7. Beyhan-Sagmen S, Baykan O, Balcan B, Ceyhan B. Association Between Severe Vitamin D Deficiency, Lung Function and Asthma Control. Arch Bronconeu- mol. 2017 Apr;53(4):186-191. 8. Martineau A R, Jolliffe D A, Hooper R L, Greenberg L, Aloia J F, Bergman P et al. Vitamin D supplementation to prevent acute respiratory tract infections: sys- tematic review and meta-analysis of individual participant data BMJ 2017; 356 :i6583 9. Marik PE, Kory P, Varon J. Does vitamin D status impact mortality from SARS-CoV-2 infection?. Med Drug Discov. 2020;6:100041. 10. Ye Q, Wang B, Mao J. The pathogenesis and treatment of the `Cytokine Storm’ in COVID-19. J Infect. 2020;80(6):607-613. doi:10.1016/j.jinf.2020.03.037 11. Biesalski HK. Vitamin D deficiency and co-morbidities in COVID-19 patients – A fatal relationship?. Nfs Journal. 2020;20:10-21. doi:10.1016/j.nfs.2020.06.001 12. https://clinicaltrials.gov/ct2/results?cond=vitamin+D+and+- Covid-19&Search=Apply&age_v=&gndr=&type=&rslt= 13. Kweder H, Eidi H. Vitamin D deficiency in elderly: Risk factors and drugs impact on vitamin D status. Avicenna J Med. 2018;8(4):139-146. doi:10.4103/ajm. AJM_20_18 14. https://www.thelancet.com/journals/landia/article/PIIS2213-8587(21)00003- 6/fulltext 15. Dofferhoff ASM, et al, Reduced vitamin K status as a potentially modifiable risk factor of severe COVID-19. Clin Infect Dis. 2020 Aug 27:ciaa1258. 16. Janssen R, Visser MPJ, Dofferhoff ASM, Vermeer C, Janssens W, Walk J. Vita-

min K metabolism as the potential missing link between lung damage and thrombo- embolism in Coronavirus disease 2019. Br J Nutr. 2021 Jul 28;126(2):191-198. 17. Kudelko, M.; Yip, T.F.; Hei Law, G.C.; Lee, S.M.Y. Potential Beneficial Effects of Vitamin K in SARS-CoV-2 Induced Vascular Disease? Immuno 2021, 1, 17-29.