Curcumex

content01 Our features? 03 What is curcumex? 08 Anti-inflammatory 10 Dramatically increases the antioxidant capacity 13 Improve brain functions 15 Protect against heart diseases 19 Prevent and possibly help treat cancer 21 Prevent & treat alzheimer’s disease

content23 Alleviate arthritis 25 Incredible benefits against depression 27 Prevent or even treat diabetes 28 Improve skin health 29 Antiviral 32 Fight helicobacter pylori (H. pylori) infections 34 Aids in weight loss 35 Combat ulcerative collitis

www.nhf.com.my OUR FEATURES | 1

www.nhf.com.my 2 | OUR FEATURES

3 | WHAT IS CURCUMEX? www.nhf.com.my



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www.nhf.com.my 6 | WHAT IS CURCUMEX?

www.nhf.com.my 7 | WHAT IS CURCUMEX?

www.nhf.com.my 8 | ANTI-INFLAMMATORY

www.nhf.com.my 9 | ANTI-INFLAMMATORY

www.nhf.com.my Dramatically Increases the Antioxidant Capacity | 10

www.nhf.com.my 11 | Dramatically Increases the Antioxidant Capacity

www.nhf.com.my 12 | Dramatically Increases the Antioxidant Capacity

13 | Improve Brain Functions www.nhf.com.my

www.nhf.com.my www.nhf.com.my 14 | Improve Brain Functions

15 | Protect Against Heart Diseases www.nhf.com.my

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www.nhf.com.my 17 | Protect Against Heart Diseases

18 | Protect Against Heart Diseases

www.nhf.com.my 19 | Prevent (and Possibly Help Treat) Cancer

www.nhf.com.my 20 | Prevent (and Possibly Help Treat) Cancer

www.nhf.com.my Prevent & Treat Alzheimer’s Disease | 21

www.nhf.com.my 22 | Prevent & Treat Alzheimer’s Disease

www.nhf.com.my 23 | Alleviate Arthritis

www.nhf.com.my

www.nhf.com.my 25 | Incredible Benefits against Depression

www.nhf.com.my 26 | Incredible Benefits against Depression

www.nhf.com.my 27 | Prevent or Even Treat Diabetes

www.nhf.com.my 28 | Improve Skin Health

www.nhf.com.my antiviral | 29

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www.nhf.com.my 31 | antiviral

32 | Fight Helicobacter Pylori (H. pylori) Infections www.nhf.com.my

www.nhf.com.my 33 | Fight Helicobacter Pylori (H. pylori) Infections

34 | Aids in Weight Loss www.nhf.com.my

www.nhf.com.my 35 | Combats Ulcerative Collitis (UC)

www.nhf.com.my 36 | Combats Ulcerative Collitis (UC)



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diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs R D. 2008;9(4):243-50. 12. Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutr Res. 2012 Oct;32(10):795-9. 13. Wongcharoen, Wanwarang et al. The protective role of curcumin in cardiovascular diseases, International Journal of Cardiology, Volume 133, Issue 2, 145 - 151 . 14. Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB. Curcumin and cancer: an \"old-age\" disease with an \"age-old\" solu- tion. Cancer Lett. 2008 Aug 18;267(1):133-64. 15. Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?. AAPS J. 2009;11(3):495-510. 16. Bar-Sela G, Epelbaum R, Schaffer M. Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications. Curr Med Chem. 2010;17(3):190-7. 17. Carroll RE, Benya RV, Turgeon DK, Vareed S, Neuman M, Rodri- guez L, Kakarala M, Carpenter PM, McLaren C, Meyskens FL Jr, Bren- ner DE. Phase IIa clinical trial of curcumin for the prevention of col- orectal neoplasia. Cancer Prev Res (Phila). 2011 Mar;4(3):354-64. 18. Mishra S, Palanivelu K. The effect of curcumin (turmeric) on Alz- heimer's disease: An overview. Ann Indian Acad Neurol. 2008;11(1):13-19. 19. Zhang L, Fiala M, Cashman J, Sayre J, Espinosa A, Mahanian M, Zaghi J, Badmaev V, Graves MC, Bernard G, Rosenthal M. Curcumi- noids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients. J Alzheimers Dis. 2006 Sep;10(1):1-7. 20. Ying Xu, Baoshan Ku, Lu Tie, Haiyan Yao, Wengao Jiang, Xing Ma, Xuejun Li, Curcumin reverses the effects of chronic stress on be- havior, the HPA axis, BDNF expression and phosphorylation of CREB, Brain Research, Volume 1122, Issue 1, 2006, Pages 56-64. 21. Binu Chandran & Ajay Goel, A Randomized, Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis, PHYTOTHERAPY RESEARCH, Phytother. Res. (2012). 22. Deodhar SD, Sethi R, Srimal RC. Preliminary study on antirheu- matic activity of curcumin (diferuloyl methane). Indian J Med Res. 1980 Apr;71:632-4. PMID: 7390600. 23. Zhang Z, Leong DJ, Xu L, et al. Curcumin slows osteoarthritis

progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model. Arthritis Res Ther. 2016;18(1):128. Published 2016 Jun 3. 24. Sanmukhani J, Satodia V, Trivedi J, Patel T, Tiwari D, Panchal B, Goel A, Tripathi CB. Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. Phytother Res. 2014 Apr;28(4):579-85. 25. Kulkarni, S.K., Bhutani, M.K. & Bishnoi, M. Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psycho- pharmacology 201, 435 (2008). 26. Zhang DW, Fu M, Gao SH, Liu JL. Curcumin and diabetes: a sys- tematic review. Evid Based Complement Alternat Med. 2013;2013:636053. 27. Kim Y, Rouse M, González-Mariscal I, Egan JM, O'Connell JF. Dietary curcumin enhances insulin clearance in diet-induced obese mice via regulation of hepatic PI3K-AKT axis and IDE, and preservation of islet integrity. Nutr Metab (Lond). 2019 Jul 25;16:48. 28. Nardo VD, Gianfaldoni S, Tchernev G, et al. Use of Curcumin in Psoriasis. Open Access Maced J Med Sci. 2018;6(1):218-220. Published 2018 Jan 21. 29. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6. 30. Zahedipour, F, Hosseini, SA, Sathyapalan, T, et al. Potential effects of curcumin in the treatment of COVID‐19 infection. Phytotherapy Re- search. 2020; 1– 10. 31. Utomo, R. Y., & Meiyanto, E. (2020). Revealing the potency of citrus and galangal constituents to Halt SARS‐CoV‐2 infection. Preprints, 2020030214. 32. Rajesh K. et al, Antiviral and immunomodulatory activity of cur- cumin: A case for prophylactic therapy for COVID-19, Heliyon, Volume 7, Issue 2, 2021. 33. Innova Database 2018, 2. Sreeraj et al., J Nutr Food Sci 2016, 6:2 34. Biofilm and Helicobacter pylori: from environment to human host. García A, Salas-Jara MJ, Herrera C, González C World J Gastroenterol. 2014 May 21; 20(19):5632-8. 35. Curcumin inhibits gastric inflammation induced by Helicobacter pylori infection in a mouse model. Santos AM, Lopes T, Oleastro M, Gato IV, Floch P, Benejat L, Chaves P, Pereira T, Seixas E, Machado J, Guerreiro AS, Nutrients. 2015 Jan 6; 7(1):306-20. 36. Vetvicka V, Vetvickova J, Fernandez-Botran R. Effects of curcumin

on Helicobacter pylori infection [published correction appears in Ann Transl Med. 2017 Mar;5(6):153]. Ann Transl Med. 2016;4(24):479. 37. Bradford PG. Curcumin and obesity. Biofactors. 2013 Jan-Feb;39(1):78-87. 38. Teich T, Pivovarov JA, Porras DP, Dunford EC, Riddell MC. Cur- cumin limits weight gain, adipose tissue growth, and glucose intolerance following the cessation of exercise and caloric restriction in rats. J Appl Physiol (1985). 2017 Dec 1;123(6):1625-1634. 39. Di Pierro F, Bressan A, Ranaldi D, Rapacioli G, Giacomelli L, Ber- tuccioli A. Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Prelimi- nary study. Eur Rev Med Pharmacol Sci. 2015 Nov;19(21):4195-202. PMID: 26592847. 40. Akbari M, Lankarani KB, Tabrizi R, Ghayour-Mobarhan M, Peyma- ni P, Ferns G, Ghaderi A, Asemi Z. The Effects of Curcumin on Weight Loss Among Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Pharmacol. 2019 Jun 12;10:649. 41. Chandan S, Mohan BP, Chandan OC, et al. Curcumin use in ulcer- ative colitis: is it ready for prime time? A systematic review and me- ta-analysis of clinical trials. Ann Gastroenterol. 2020;33(1):53-58. doi:10.20524/aog.2019.0439 42. Curcumin downregulates human tumor necrosis factor-α levels: A systematic review and meta-analysis ofrandomized controlled trials. Sahebkar A, Cicero AFG, Simental-Mendía LE, Aggarwal BB, Gupta SC Pharmacol Res. 2016 May; 107():234-242.