Bio Organix EN

Contents 1 What is Bio Organix? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2 Our Features . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 3 What is Dietary Fiber? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 4 Feeds Good Gut Bacteria . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  5 5 Promotes Gut Health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  7 6 Promotes Weight Loss . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 7 Protections Against Heart Disease . . . . . . . . . . . . . . . . . . . . . . . . 11 8 Prevents Type-2 Diabetes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  13 9 Reduces Risk of Colorectal Cancer . . . . . . . . . . . . . . . . . . . . . .  15 10 Anti-Inflammatory . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  17 11 Anti-Aging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT CHAPTER 1 What is Bio Organix? www.nhf.comB.myio Organix is a perfect blend of more than 48 organic vegetables & fruits extracts, complete with more than 1 Billion organ- ically cultured Probiotics (Lactobacillus Acidophi- lus). It is a multi-faceted nu- trition as well as providing optimum amount of High www.nhf.com.my Fiber (Soluble + Insoluble) Daily Supplement. 1

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT CHAPTER 2 Our Features .my1. Specially formulated w.nhf.comto contain optimum amount & balance of Sol- uble-Insoluble Fiber for unsurpassed health bene- fits. ww2. Contains more than 48 types of organic veg- etables-fruits extracts for optimum nutrition com- www.nhf.com.my position. Only finest, best quality ingredients supplier are selected. 3. Contains more than 1 billion of Organically Cultured Probiotics (Lacto- bacillus Acidophilus) to give synergistic boost to the effects. 4. Best taste and palatability compared to other brands. 5. Over 20 years of human consumption with tens of thousands of re- al-life testimonials. 2

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT CHAPTER 3 What is Dietary Fiber? .myietary Fiber is a type D w.nhf.comof carbohydrate that the body can’t digest. Though most carbohy- drates are broken down into sugar molecules, fiber wwcannot be broken down into sugar molecules, and instead it passes through the body undigested. Fiber comes in two variet- www.nhf.com.my ies, both beneficial to health: • Soluble fiber, which dissolves in water, can be metabolized by the “good” bacteria in the gut, help lower glucose levels as well as lower blood cholesterol. Foods with soluble fiber include oatmeal, nuts, beans, lentils, apples and blueberries. • Insoluble fiber, which does not dissolve in water, can help food move through your digestive system, help prevent constipation. Foods with insoluble fibers include whole wheat, whole grain, carrots, vegetables. 3

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT There is also a lot of overlap between soluble and insoluble fibers. Some insoluble fibers can be digested by the good bacteria in the intestine, and most foods contain both soluble and insoluble fibres. Health authorities recommend that men eat at least 38 grams of fiber per day, whilst women should consume at least 25 grams of fiber a day. Peo- ple need less fiber after 50 years of age at around 21 g for women and 30 g for men. During pregnancy or breastfeeding, women should aim for at least 28 g per day. www.nhf.com.mywww.nhf.com.my 4

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT CHAPTER 4 Feeds Good Gut Bacteria .myhe bacteria that live in T w.nhf.comthe human body out- number the body’s cells 10 to 1. Bacteria live on the skin, in the mouth and in the nose, but the great wwmajority live in the gut, pri- marily the large intestine. About 500 different spe- cies of bacteria live in the www.nhf.com.my intestine, totalling about 100 trillion cells. These gut bacteria are also known as the gut flora. This is not a bad thing. In fact, there is a mutually beneficial relationship be- tween you and some of the bacteria that live in your digestive system. Of the many different kinds of bacteria, some are crucial for various as- pects of your health, including weight, blood sugar control, immune func- tion and even brain functions [1]. Just like any other organism, bacteria need to eat to get energy to survive and function. 5

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT The problem is that most carbs, proteins and fats are absorbed into the bloodstream before they make it to the large intestine, leaving little for the gut flora. This is where fiber comes in. Human cells don’t have the enzymes to digest fiber, so it reaches the large intestine relatively un- changed. This is the most important reason that dietary fibers are important for health. They feed the “good” bacteria in the intestine, functioning as prebiotics. In this way, they promote the growth of “good” gut bacteria, which can have various positive effects on health [2]. The friendly bacteria produce nutrients for the body, including short-chain fatty acids like acetate, propionate and butyrate, of which butyrate ap- pears to be the most important. These short-chain fatty acids can feed the cells in the colon, leading to reduced gut inflammation and improve- ments in digestive disorders like irritable bowel syndrome, Crohn’s dis- yease and ulcerative colitis [3]. w.nhf.com.mWhen the bacteria ferment the fiber, they also produce gases. This is the reason high-fiber diets can cause flatulence and stomach discomfort in some people. These side effects usually go away with time as your body wwadjusts. 6

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT CHAPTER 5 Promotes Gut Health www.nhf.com.myFiber is important for keeping the gut healthy. Eating enough fiber can prevent or relieve consti- pation, helping waste to move smoothly through the body. According to a 2015 scientific review, dietary fiber increases the bulk of stool, helps www.nhf.com.my promote regular bowel movements, and reduc- es the time that waste spends inside the intestines [4]. Some studies show that increasing fiber can improve symptoms of consti- pation, but other studies show that removing fiber improves constipation .[14] The effects depend on the type of fiber. In general, fiber that increas- es the water content of your stool has a laxative effect, while fiber that adds to the dry mass of stool without increasing its water content may have a constipating effect. 7

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT Soluble fibers that form a gel in the digestive tract and are not fermented by gut bacteria are often effective .[15] A good fiber supplement has to be meticulously formulated to yield gut movement effects. Bio Organix is specially formulated and tested over 20 years of practical consumption. It has been proven to induce effective colonic movement to provide a lasting solution for constipation. According to a 2009 review, dietary fiber has a positive impact on gastro- intestinal disorders, including: colorectal ulcer, hiatal hernias, gastro- esophageal reflux disease, diverticular disease & hemorrhoids [5]. www.nhf.com.my www.nhf.com.my 8

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT CHAPTER 6 Promotes Weight Loss .myor people aiming to F w.nhf.comlose weight, a diet high in dietary fiber can help regulate weight loss. High fiber foods help a person feel fuller for longer and wwmay help people adhere to a diet. In fact, some studies show that increasing dietary fi- www.nhf.com.my ber can cause weight loss by automatically reducing calorie intake [6]. Fiber can soak up water in the intestine, slowing the absorption of nutrients and increasing feelings of fullness. A clinical study concluded that a 16-week dietary soluble supplementation in overweight & obese persons are well tolerated and exerted positive fat-reducing effects [7]. Fiber supplementation also shown to induce sa- tiety and had beneficial effects on some CVD risk factors, the most im- portant of which was a significant decrease in plasma LDL-cholesterol 9

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT concentrations. In a 2019 clinical study involving 345 obese subjects, researchers con- cluded that people who increased their dietary fiber intake were suc- cessful in their weight loss regime and adherence to their dietary caloric restriction [8]. www.nhf.com.mywww.nhf.com.my 10

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT CHAPTER 7 Protections Against Heart Disease www.nhf.com.myHigh intake of dietary fiber has been linked to a lower risk of heart disease in a number of large studies that fol- lowed people for many years. In a Harvard study of over 40,000 male health professionals, researchers found that www.nhf.com.my a high total dietary fiber intake was linked to a 40 percent lower risk of coronary heart disease [9]. Another study showed that when you eat a high-fiber diet, you lower your risk of coronary artery disease and heart attack by as much as 40% - 50% .[24] Several studies over the past several decades have examined dietary fi- ber’s effect on heart health, including preventing cardiovascular disease and reducing blood pressure. A 2017 review of scientific studies con- cluded that supplementing with high fiber significantly reduced risk of cardiovascular disease and lower mortality from these conditions .[10] 11

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT The authors concluded that these heart protective effects could be be- cause fiber reduces total cholesterol and low-density lipoprotein (LDL) cholesterol, also called ‘bad cholesterol,’ which is a major risk for heart conditions. .my www.nhf.com.my w.nhf.comHigher fiber intake has also been linked to a lower risk of metabolic syn- drome, a combination of factors that increases the risk of developing heart disease and diabetes. These factors include high blood pressure, high insulin levels, excess weight (especially around the abdomen), high wwlevels of triglycerides, and low levels of HDL (good) cholesterol .[11] www.nhf.com.my 12

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT CHAPTER 8 Prevents Type-2 Diabetes .mydding more fiber to the A w.nhf.comdiet may also have benefits for diabetes. Fi- ber can help slow down the body’s absorption of sugar, helping to prevent wwblood sugar spikes after meals. A 2018 review re- ports that high intake of fiber had a lower risk of developing type 2 diabe- www.nhf.com.my tes. These individuals also reported a significant reduction in blood glucose levels .[12] Diets low in fiber and high in carbs that cause sudden spike in blood sug- ar may increase the risk of developing type 2 Diabetes. Harvard stud- ies—of female nurses and of male health professionals—found that this typical diet more than doubled the risk of type 2 diabetes when com- pared to a high-fiber diet .[9,13] Another study was done in 2012 using fiber-rich supplement on eleven 13

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT type-2 diabetic subjects for blood glucose lowering effect .[23] Results with respect to two months supplementation indicated that the fiber rich supplement was helpful in significantly reducing the fasting blood glucose level of subjects. www.nhf.com.mywww.nhf.com.my 14

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT CHAPTER 9 Reduces Risk of Colorectal Cancer www.nhf.comC.myolorectal cancer is the third leading cause of cancer deaths in the world. Many stud- ies have linked a high intake of fiber-rich foods with a reduced risk of co- lon cancer .[16] This large, prospective study within a population-based trial www.nhf.com.my suggests that individuals consuming the highest intakes of dietary fiber have reduced risks of incident colorectal adeno- ma and distal colon cancer. Dietary fiber may help in preventing colorectal cancer through several mechanism .[17] 1. Dietary fiber resists digestion in the small intestine, and enters the colon where it is fermented to produce short chain fatty acids (SCFA) that may enhance the healthy composition of gut microbiota. 15

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT 2. SCFAs have anticancer properties which include the promotion of cancer cell cycle arrest, apoptosis, and the inhibition of chronic inflam- matory process and cancer cell migration/invasion in the colon. Impor- tantly, these molecular activities are effective only within a certain physio- logical concentration range of the SCFAs. 3. Dietary fiber increases fecal bulking and viscosity, reduces the time for proteolytic fermentation that results in harmful substances, and short- ens the contact between potential carcinogens and mucosal cells. 4. In addition, dietary fiber can bind/excrete potential luminal carcino- gens (e.g., secondary bile acids), lower fecal pH in the colon, and thus provide a healthy intestinal environment. www.nhf.com.my www.nhf.com.my 16

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT CHAPTER 10 Anti-In ammatory .myuman gut is coated H w.nhf.comwith a layer of mucus, atop which sits a carpet of hundreds of species of bacteria, part of the hu- man microbiome. Some wwof these microbes carry the enzymes needed to break down various kinds of dietary fiber. Scientists marvelled on how nature www.nhf.com.my works when they discov- ered that beneficial microbes tend to thrive on high-fiber environment whilst “bad” microbes feed on high fat, high sugar diets .[18] In this study, scientists observed that the intestines got smaller, and its mu- cus layer thinner as they switched the food from high-fiber to high-fat, high lard diet. As a result, bacteria wound up much closer to the intesti- nal wall, and that encroachment triggered an immune reaction. 17

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT www.nhf.com.my yFigure: High Fiber Diet Restored Microbiota Loads and Prevented HFD-In- .mduced Microbiota Encroachment w.nhf.comJustin L. Sonnenburg, a biologist at Stanford University said that a low-fi- ber diet can cause inflammation not only in the gut, but throughout the body. His research suggests that when bacteria break down dietary fi- ber down into short-chain fatty acids, some of them pass into the blood- wstream and travel to other organs, where they act as signals to quiet wdown the immune system .[19] 18

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT High-fiber diet potentially lowers inflammation by modifying both the pH and the permeability of the gut .[20] The resultant reduction in inflamma- tory compounds may alter neurotransmitter concentrations to reduce symptoms of depression. www.nhf.com.mywww.nhf.com.my 19

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT CHAPTER 11 Anti-Aging www.nhf.com.myA higher dietary fiber in- take was associated with a reduced risk of death. A meta-analysis was done using seven- teen scientific studies that had a total of 67,260 deaths and 982,411 subjects .[21] When com- paring persons with di- www.nhf.com.my etary fiber intakes in the top tertile with persons whose intakes were in the bottom tertile, they found a statistically signifi- cant inverse association between fiber intake and all-cause mortality. Another team of researchers found that out of all the factors they examined -- which included a person’s total carbohydrate intake, total fiber intake, glycemic index, glycemic load, and sugar intake -- it was the fiber that made the biggest difference to what the researchers termed “successful aging.” [22] 20

BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT Successful aging was defined as including an absence of disability, de- pressive symptoms, cognitive impairment, respiratory symptoms, and chronic diseases including cancer, coronary artery disease, and stroke. Essentially, they found that those who had the highest intake of fiber ac- tually had an almost 80% greater likelihood of living a long and healthy life over a 10-year follow-up. www.nhf.com.my www.nhf.com.my 21

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BIO ORGANIX COMPLETE COMPREHENSIVE NUTRITIONAL SUPPLEMENT 18. https://www.cell.com/cell-host-microbe/fulltext/S1931- 3128(17)30497-3 19. Sonnenburg, E.D., Sonnenburg, J.L. The ancestral and industrialized gut microbiota and implications for human health. Nat Rev Microbiol 17, 383–390 (2019). 20. Swann OG, Kilpatrick M, Breslin M, Oddy WH. Dietary fiber and its associations with depression and inflammation. Nutr Rev. 2020 May 1;78(5):394-411. 21. Yang Yang, Long-Gang Zhao, Qi-Jun Wu, Xiao Ma, Yong-Bing Xiang, Association Between Dietary Fiber and Lower Risk of All-Cause Mortality: A Meta-Analysis of Cohort Studies, American Journal of Epidemiology, Volume 181, Issue 2, 15 January 2015, Pages 83–91 22. Bamini Gopinath et al. Association Between Carbohydrate Nutrition and Successful Aging Over 10 Years. The Journals of yGerontology, Series A: Biological Sciences and Medical Sciences, May .m2016 w.nhf.com23. Medhe, Seema & Medhe, Mangal. (2013). EFFECT OF FIBER SUPPLEMENT ON BLOOD GLUCOSE LEVEL OF NIDDM SUBJECTS. international journal of bioassys. 2. ISSN: 2278-778X. 24. Jensen MK, Koh-Banerjee P, Hu FB, et al. Intakes of whole grains, wwbran, and germ and the risk of coronary heart disease in men. Am J Clin Nutr 2004; 80:1492. 24