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KYK Hydrogen Water Chinese Version

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11. Li J, Wang C, Zhang JH , Cai JM, Cao YP, Sun XJ. Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by re- duction of oxidative stress. Brain Res. 2010 Apr 30;1328:152-61. 12. Wang H, Huo X, Chen H, et al. Hydrogen-Rich Saline Activated Autopha- gy via HIF-1α Pathways in Neuropathic Pain Model. Biomed Res Int. 2018 May 17;2018:4670834. 13. Wu X, Li X, Liu Y, Yuan N, et al. Hydrogen exerts neuroprotective effects on OG- D/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway. Brain Res. 2018 Nov 1;1698:89-98. 14. Mizuno K, Sasaki AT, Ebisu K, Tajima K, Kajimoto O, Nojima J, Kuratsune H, Hori H, Watanabe Y. Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life. Med Gas Res. 2018 Jan 22;7(4):247-255. 15. Gao Q, Song H, Wang XT, et al. Molecular hydrogen increases resilience to stress in mice. Sci Rep. 2017;7(1):9625. Published 2017 Aug 29. 16. Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. J Clin Biochem Nutr. 2010;46(2):140-149. 17. Aoki K, Nakao A, Adachi T, Matsui Y, Miyakawa S. Pilot study: Effects of drink- ing hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Med Gas Res. 2012;2:12. Published 2012 Jul 12. doi:10.1186/2045-9912-2-12 18. Da Ponte A, Giovanelli N, Nigris D, Lazzer S. Effects of hydrogen rich water on prolonged intermittent exercise. J Sports Med Phys Fitness. 2018 May;58(5):612-621. 19. LeBaron TW, Laher I, Kura B, Slezak J. Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes 1. Can J Physiol Pharmacol. 2019 Sep;97(9):797-807. 20. Wan-Jun Zhu, Masaaki Nakayama, Takefumi Mori, et al. Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal inju- ry in Dahl salt-sensitive rats, Nephrology Dialysis Transplantation, Volume 26, Issue 7, July 2011. 47

21. Nakayama, M., Kabayama, S. & Ito, S. The hydrogen molecule as antioxidant therapy: clinical application in hemodialysis and perspectives. Ren Replace Ther 2, 23 (2016). 22. Nakayama M, Itami N, Suzuki H, et al. Possible clinical effects of molecular hy- drogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation. PLoS One. 2017;12(9):e0184535. Published 2017 Sep 13. 23. Xin HG, Zhang BB, Wu ZQ, Hang XF, Xu WS, Ni W, Zhang RQ, Miao XH. Con- sumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats. Mol Cell Biochem. 2014 Jul;392(1-2):117-24. 24. Amitani H, Asakawa A, Cheng K, et al. Hydrogen improves glycemic control in type1 diabetic animal model by promoting glucose uptake into skeletal muscle [pub- lished correction appears in PLoS One. 2013;8(4). 25. M. Chen, J. Zhang, Y. Chen et al., “Hydrogen protects lung from hypoxia/re-oxy- genation injury by reducing hydroxyl radical production and inhibiting inflammatory responses,” Scientific Reports, vol. 8, no. 1, p. 8004, 2018. 26. W. Liu, L. P. Shan, X. S. Dong, X. W. Liu, T. Ma, and Z. Liu, “Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury,” World Jour- nal of Gastroenterology, vol. 19, no. 4, pp. 492–502, 2013. 27. Meng J, Yu P, Jiang H, et al. Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress. Am J Transl Res. 2016;8(10):4472- 4477. Published 2016 Oct 15. 28. Zhang, Y., Su, WJ., Chen, Y. et al. Effects of hydrogen-rich water on depres- sive-like behavior in mice. Sci Rep 6, 23742 (2016). 29. Ohsawa, Ikuroh & Nishimaki, Kiyomi & Yamagata, Kumi & Ishikawa, Masahiro & Ohta, Shigeo. (2008). Consumption of hydrogen water prevents atherosclerosis in apoliporotein E knockout mice. Biochemical and Biophysical Research Communica- tions. 377. 1195-1198. 10.1016/j.bbrc.2008.10.156. 30. Iketani, M., Sekimoto, K., Igarashi, T. et al. Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice. Sci Rep 8, 16822 (2018). 31. Yoritaka, A., Takanashi, M., Hirayama, M., Nakahara, T., Ohta, S. and Hattori, N. (2013), Pilot study of H2 therapy in Parkinson’s disease: A randomized double‐blind 48

placebo‐controlled trial. Mov Disord., 28: 836-839. 32. Zhao M, Liu MD, Pu YY, Wang D, Xie Y, Xue GC, Jiang Y, Yang QQ, Sun XJ, Cao L. Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice. J Neuroimmunol. 2016 May 15;294:6-13. 33. Shirahata S, Hamasaki T, Haramaki K, et al. Anti-diabetes effect of water contain- ing hydrogen molecule and Pt nanoparticles. BMC Proc. 2011;5 Suppl 8(Suppl 8):P18. Published 2011 Nov 22. 34. Kim MJ, Jung KH, Uhm YK, Leem KH, Kim HK. Preservative effect of electro- lyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice. Biol Pharm Bull. 2007 Feb;30(2):234-6. 35. Tsai CF, Hsu YW, Chen WK, Chang WH, Yen CC, Ho YC, Lu FJ. Hepatopro- tective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol. 2009 Aug;47(8):2031-6. 36. Xia, C., Liu, W., Zeng, D., Zhu, L., Sun, X. and Sun, X. (2013), Effect of Hydro- gen‐Rich Water on Oxidative Stress, Liver Function, and Viral Load in Patients with Chronic Hepatitis B. Clinical And Translational Science, 6: 372-375. 37. Shin DW, Yoon H, Kim HS, et al. Effects of Alkaline-Reduced Drinking Water on Irritable Bowel Syndrome with Diarrhea: A Randomized Double-Blind, Placebo-Con- trolled Pilot Study. Evid Based Complement Alternat Med. 2018;2018:9147914. 38. Zhu Q, Wu Y, Li Y, et al. Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. Sci Rep. 2018;8(1):8051. 39. Ignacio RM, Kwak HS, Yun YU, Sajo ME, Yoon YS, Kim CS, Kim SK, Lee KJ. The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermato- phagoides farinae Allergen in NC/Nga Mice. Evid Based Complement Alternat Med. 2013;2013:538673. 40. Kato S, Saitoh Y, Iwai K, Miwa N. Hydrogen-rich electrolyzed warm water re- presses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratino- cytes. J Photochem Photobiol B. 2012 Jan 5;106:24-33. 41. Xu FF, Yu SQ, Zhao CL, Che N, Jin L, Wang QL, Ge RM. [Effect of hydrogen-rich saline on the CD4(+) CD25(+) Foxp3(+) Treg cells of allergic rhinitis guinea pigs mod- el]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Jul 7;52(7):506-511. 49


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