生育三烯酚 高生物效力的维生素E 第 二 十 二 促进皮肤健康 章 w.nhf.com.my生育三烯酚保护膜 中的多不饱和脂肪 酸（PUFAs）不被 氧化，调节活性氧 ww（ROS）和活性氮 （RNS）的产生， 并调节信号转导。 www.nhf.com.my 在正常和疾病条件下的动物和人类模型中，已经 观察到生育三烯酚的免疫调节作用。 根据发表在《欧洲临床营养学杂志》上的一项人 体研究，与安慰剂相比，女性在接种一次破伤风 类毒素疫苗前1个月每天补充生育三烯酚，其免疫 反应得到改善[37]。 48
生育三烯酚 高生物效力的维生素E 另一项利用小鼠模型的研究表明，生育三烯酚可 使T细胞增殖增强，这说明生育三烯酚的生物利用 度可使其达到足以影响免疫细胞功能的组织水平 [38]。另一项研究表明，口服生育三烯酚会影响脾 脏和淋巴结淋巴细胞的增殖和功能[39]。 www.nhf.com.mywww.nhf.com.my 49
生育三烯酚 高生物效力的维生素E 参考文献 1. Hong Yong Peh, W.S. Daniel Tan, Wupeng Liao, W.S. Fred Wong, “Vitamin E therapy beyond cancer: Tocopherol versus tocotrienol,” Pharmacology & Therapeutics, Volume 162, 2016, ISSN 0163-7258. 2. Wada S. Cancer preventive effects of vitamin E. Curr Pharm Biotechnol. 2012 Jan;13(1):156-64. 3. Ling MT, Luk SU, Al-Ejeh F, Khanna KK. Tocotrienol as a potential anticancer agent. Carcinogenesis. 2012 Feb;33(2):233-9. 4. Husain K, Centeno BA, Chen DT, Hingorani SR, Sebti SM, Malafa MP. Vitamin E delta-tocotrienol prolongs survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model of pancreatic cancer. Cancer Prev Res (Phila). 2013 Oct;6(10):1074-83. y5. Nesaretnam K. Multitargeted therapy of cancer by tocotrienols. .mCancer Lett. 2008 Oct 8;269(2):388-95. w.nhf.com6. Baliarsingh S, Beg ZH, Ahmad J. The therapeutic impacts of tocotrienols in type 2 diabetic patients with hyperlipidemia. Atherosclerosis. 2005 Oct;182(2):367-74. 7. Teoh MK, Chong JM, Mohamed J, Phang KS. Protection by wwtocotrienols against hypercholesterolaemia and atheroma. Med J Malaysia. 1994 Sep;49(3):255-62. 8. Prasad K. Tocotrienols and cardiovascular health. Curr Pharm Des. 2011;17(21):2147-54. 9. Norsidah KZ, Asmadi AY, Azizi A, Faizah O, Kamisah Y. Palm tocotrienol-rich fraction reduced plasma homocysteine and heart oxidative stress in rats fed with a high-methionine diet. J Physiol Biochem. 2013 Sep;69(3):441-9. 10. Das S, Mukherjee S, Lekli I, et al. Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics. Mol Cell Biochem. 2012 Jan;360(1-2):35-45. 50
生育三烯酚 高生物效力的维生素E 11. Park HA, Kubicki N, Gnyawali S, et al. Natural vitamin E alpha-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1. Stroke. 2011 Aug;42(8):2308-14. 12. Magosso E, Ansari MA, Gopalan Y, et al. Tocotrienols for normalisation of hepatic echogenic response in nonalcoholic fatty liver: a randomised placebo-controlled clinical trial. Nutr J. 2013 Dec 27;12(1):166. 13. Mangialasche F, Kivipelto M, Mecocci P, et al. High plasma levels of vitamin E forms and reduced Alzheimer’s disease risk in advanced age. J Alzheimers Dis. 2010;20(4):1029-37. 14. Taridi NM, Yahaya MF, Teoh SL, et al. Tocotrienol rich fraction (TRF) supplementation protects against oxidative DNA damage and improves cognitive functions in Wistar rats. Clin Ter. 2011;162(2):93- y8. w.nhf.com.m15. Khanna S, Patel V, Rink C, Roy S, Sen CK. Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice. Free Radical Biology & Medicine. 2005 Nov;39(10):1310-1319. DOI: 10.1016/j. freeradbiomed.2005.06.013. ww16. Ima-Nirwana S, Suhaniza S. Effects of tocopherols and tocotrienols on body composition and bone calcium content in adrenalectomized rats replaced with dexamethasone. J Med Food. 2004 Spring;7(1):45-51. 17. Soelaiman IN, Ming W, Abu Bakar R, et al. Palm tocotrienol supplementation enhanced bone formation in oestrogen-deficient rats. Int J Endocrinol. 2012;2012:532862. 18. Chin KY, Mo H, Soelaiman IN. A review of the possible mechanisms of action of tocotrienol - a potential antiosteoporotic agent. Curr Drug Targets. 2013 Dec;14(13):1533-41. 51
生育三烯酚 高生物效力的维生素E 19. Nasibah, A. & Rajikin, MH & Nor-Ashikin, Mohamed Noor Khan & Nuraliza, AS. (2012). Effects of tocotrienol supplementation on pregnancy outcome in mice subjected to maternal corticosterone administration. Journal of oil palm research. 20. Ng, Yeek Tat, Sonia Chew Wen Phang, Gerald Chen Jie Tan, En Yng Ng, Nevein Philip Botross Henien, Uma Devi M Palanisamy, Badariah Ahmad, and Khalid Abdul Kadir. “The Effects of Tocotrienol-Rich Vitamin E on Diabetic Neuropathy: A Phase II Randomized Controlled Trial.” Nutrients 12, no. 5 (2020): 1522. 21. Tan, SMQ, et al. (2018). Tocotrienol-rich vitamin E from palm oil and its effects in diabetes and diabetic nephropathy: A pilot phase II clinical trial. Nutrients, 10(9), 1315. doi:10.3390/nu10091315 22. Sadikan, M.Z.; Abdul Nasir, N.A.; Agarwal, R.; Mohd Ismail, N. Protective Effect of Palm Oil-Derived Tocotrienol-Rich Fraction yAgainst Retinal Neurodegenerative Changes in Rats with .mStreptozotocin-Induced Diabetic Retinopathy. Biomolecules 2020, w.nhf.com10, 556. 23. Chin SF, Hamid NA, Latiff AA, et al. Reduction of DNA damage in older healthy adults by Tri E Tocotrienol supplementation. Nutrition. 2008;24(1):1-10. ww24. Georgousopoulou EN, Panagiotakos DB, Mellor DD, Naumovski N. Tocotrienols, health and ageing: A systematic review. Maturitas. 2017 Jan;95:55-60. 25. Mahalingam D, Radhakrishnan AK, Amom Z, et al. Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers. Eur J Clin Nutr. 2011;65(1):63-9. 26. Serbinova E, Kagan V, Packer L, et al. (1991). Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radical Biology & medicine, 10, 263-275. 27. Traber M.G. al (1998) Lipids, 33, 87-91. 52
生育三烯酚 高生物效力的维生素E 28. Weber C, al (1997). Free Radical Biology & Medicine, 22, 761- 769 29. Tsuduki T, Kuriyama K, Nakagawa K, Miyazawa T. Tocotrienol (unsaturated vitamin E) suppresses degranulation of mast cells and reduces allergic dermatitis in mice. J Oleo Sci. 2013;62(10):825-34. 30. Lim AB, et al. (2010). Effects of Tocotrienol Supplementation on Hair Growth in Human Volunteers.Tropical Life Sciences Research, 21(2), 91-99 31. Traber MG, Podda M, Weber C, Thiele J, Rallis M, Packer L. Diet- derived and topically applied tocotrienols accumulative in skin and protect the tissue against ultraviolet light-induced oxidative stress. Asia Pacific journal of Clinical Nutrition. 1997;6(1):63–67. 32. Wan Nasri, Wan Nurzulaikha et al. ‘Tocotrienol Rich Fraction ySupplementation Modulate Brain Hippocampal Gene Expression in .mAPPswe/PS1dE9 Alzheimer’s Disease Mouse Model’. 1 Jan. 2019 : w.nhf.comS239 – S254. 33. Mohamed WM, Sayeed S, Saxena AK, Oothuman P. Oxidative Stress Status and Neuroprotection of Tocotrienols in Chronic Cerebral Hypoperfusion-Induced Neurodegeneration Rat Animal Model. Int J Nutr Pharmacol Neurol Dis 2018;8:47-52 ww34. Arguillas M, et al. , “The effect of vitamin E (mixed tocotrienol) on the liver stiffness measurement measured by transient elastography (fibroScan) among NAFLD patients”, (June 7th, 2013). APAS Liver Week. Singapore. 35. Yap SP, et al. (2003). Influence of route of administration on the absorption and disposition of alpha-, gamma-, and delta- tocotrienols in rats. Journal of Pharmacy and Pharmacology, 55, 53- 58 36. Serbinova EA, Packer L. Antioxidant properties of alpha- tocopherol and alpha-tocotrienol. Methods Enzymol 1994;234:354– 66 53
生育三烯酚 高生物效力的维生素E 37. Mahalingam D, Radhakrishnan AK, Amom Z, Ibrahim N, Nesaretnam K. Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers. Eur J Clin Nutr. 2011 Jan;65(1):63-9. 38. Ren Z, Pae M, Dao MC, Smith D, Meydani SN, Wu D. Dietary supplementation with tocotrienols enhances immune function in C57BL/6 mice. J Nutr. 2010;140(7):1335-1341. doi:10.3945/ jn.110.121434 39. Gu JY, Wakizono Y, Sunada Y, Hung P, Nonaka M, Sugano M, Yamada K. Dietary effect of tocopherols and tocotrienols on the immune function of spleen and mesenteric lymph node lymphocytes in Brown Norway rats. Biosci Biotechnol Biochem. 1999 Oct;63(10):1697-702. 40. CK Sen. (2006, September 15 - 31). Alpha-tocotrienol: A Potent yNeuroprotective Natural Vitamin E. Medical Tribune. w.nhf.com.m41. Pearce BC, et.al (1994). Inhibitors of cholesterol biosynthesis. Hypocholesterolemic and antioxidant activities of benzopyran and tetrahydronaphthalene analogues of the tocotrienols. Journal of Medicinal Chemistry; 37:526–541. 42. Watson, R.R, et.al (2008). Tocotrienols: Vitamin E Beyond wwTocopherols. USA. CRC Press. pp.269-270. 43. Hor CP, Fung WY, Ang HA, et al. Efficacy of Oral Mixed Tocotrienols in Diabetic Peripheral Neuropathy: A Randomized Clinical Trial. JAMA Neurol. 2018 Apr 1;75(4):444-452. 54
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