Perfect Pair K2 & D3 English

CONTENT01 What is Vitamin D3? 04 Ampli-D® - A 3x faster and more effective form of vitamin D3 06 What is Vitamin K2?



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References 1. Tripkovic L, Lambert H, Hart K, et al. Comparison of vitamin D2 and vita- min D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 2012;95(6):1357-1364. 2. Newman P., Shearer M.J. (1998) Vitamin K Metabolism. In: Quinn P.J., Kagan V.E. (eds) Fat-Soluble Vitamins. Subcellular Biochemistry, vol 30. Springer, Boston, MA. 3. van Ballegooijen AJ, Pilz S, Tomaschitz A, Grübler MR, Verheyen N. The Syn- ergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review. Int J Endocrinol. 2017;2017:7454376. 4. Koshihara Y, Hoshi K. Vitamin K2 enhances osteocalcin accumulation in the extracellular matrix of human osteoblasts in vitro. J Bone Miner Res. 1997 Mar;12(3):431-8. 5. Hector F DeLuca, Overview of general physiologic features and functions of vitamin D, The American Journal of Clinical Nutrition, Volume 80, Issue 6, Decem- ber 2004, 6. Anderson PH, Lam NN, Turner AG, Davey RA, Kogawa M, Atkins GJ, Morris HA. The pleiotropic effects of vitamin D in bone. J Steroid Biochem Mol Biol. 2013 Jul;136:190-4. 7. van Leeuwen JP, van Driel M, van den Bemd GJ, Pols HA. Vitamin D control of osteoblast function and bone extracellular matrix mineralization. Crit Rev Eu- karyot Gene Expr. 2001;11(1-3):199-226. PMID: 11693961. 8. Berry JL, Davies M, Mee AP. Vitamin D metabolism, rickets, and osteomala- cia. Semin Musculoskelet Radiol. 2002 Sep;6(3):173-82. 9. Mahon P, Harvey N, Crozier S, et al. Low maternal vitamin D status and fetal bone development: cohort study. J Bone Miner Res. 2010;25(1):14-19. 10. Ushiroyama T, Ikeda A, Ueki M. Effect of continuous combined therapy with vitamin K(2) and vitamin D(3) on bone mineral density and coagulofibrinolysis function in postmenopausal women. Maturitas. 2002 Mar 25;41(3):211-21. 11. Cranney A et al, Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess (Full Rep). 2007 Aug;(158):1-235. PMID: 18088161; PMCID: PMC4781354. 12. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the el- derly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001 Aug;22(4):477-501. 13. Peppone LJ, Hebl S, Purnell JQ, Reid ME, Rosier RN, Mustian KM, Palesh OG, Huston AJ, Ling MN, Morrow GR. The efficacy of calcitriol therapy in the management of bone loss and fractures: a qualitative review. Osteoporos Int. 2010 Jul;21(7):1133-49. 14. Tang BM, Eslick GD, Nowson C, et al. Use of calcium or calcium in combi- nation with vitamin D supplementation to prevent fractures and bone loss in people

aged 50 years and older: a meta-analysis. 2007. 15. Marie C. et al., Vitamin D3 and Calcium to Prevent Hip Fractures in Elderly Women, N Engl J Med 1992; 327:1637-1642. 16. Knapen, M.H.J., Drummen, N.E., Smit, E. et al. Three-year low-dose men- aquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int 24, 2499–2507 (2013). 17. Iwamoto J, Takeda T, Ichimura S. Effect of combined administration of vita- min D3 and vitamin K2 on bone mineral density of the lumbar spine in postmeno- pausal women with osteoporosis. J Orthop Sci. 2000;5(6):546-51. 18. Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of car- diovascular disease. Circulation. 2008;117(4):503-511. doi:10.1161/CIRCULATION- AHA.107.706127 19. Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, Hathcock J, Giovannucci E, Willett WC. Benefit-risk assessment of vitamin D supplementation. Osteoporos Int. 2010;21(7):1121-1132. 20. Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004 Nov;134(11):3100-5. 21. Van Ballegooijen, A. J., Pilz, S., Tomaschitz, A., Grübler, M. R., & Verheyen, N. (2017). The synergistic interplay between vitamins D and K for bone and cardio- vascular health: a narrative review. International journal of endocrinology, 2017. 22. Van Ballegooijen, A. J., Cepelis, A., Visser, M., Brouwer, I. A., Van Schoor, N. M., & Beulens, J. W. (2017). Joint association of low vitamin D and vitamin K status with blood pressure and hypertension. Hypertension, 69(6), 1165-1172. 23. Ken C Chiu, Audrey Chu, Vay Liang W Go, Mohammed F Saad, Hypovita- minosis D is associated with insulin resistance and β cell dysfunction, The American Journal of Clinical Nutrition, Volume 79, Issue 5, May 2004, Pages 820–825 24. Mathieu, C., Gysemans, C., Giulietti, A. et al. Vitamin D and diabetes. Diabe- tologia 48, 1247–1257 (2005). 25. Knekt P, Laaksonen M, Mattila C, Härkänen T, Marniemi J, Heliövaara M, Rissanen H, Montonen J, Reunanen A. Serum vitamin D and subsequent occurrence of type 2 diabetes. Epidemiology. 2008 26. Mitri J, Dawson-Hughes B, Hu FB, Pittas AG. Effects of vitamin D and calci- um supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial. Am J Clin Nutr. 2011;94(2):486-494. 27. Snijder MB, van Dam RM, Visser M, Deeg DJ, Dekker JM, Bouter LM, Seidell JC, Lips P. Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J Clin Endocrinol Metab. 2005 Jul;90(7):4119-23. 28. Lee P, Greenfield JR, Seibel MJ, Eisman JA, Center JR. Adequacy of vitamin D replacement in severe deficiency is dependent on body mass index. Am J Med. 2009

Nov;122(11):1056-60. 29. Salehpour A, Hosseinpanah F, Shidfar F, et al. A 12-week double-blind ran- domized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women. Nutr J. 2012;11:78. Published 2012 Sep 22. 30. Chon SJ, Yun BH, Jung YS, Cho SH, Choi YS, et al. (2014) Association be- tween Vitamin D Status and Risk of Metabolic Syndrome among Korean Postmeno- pausal Women. PLOS ONE 9(2): e89721. 31. Garland CF, Garland FC, Gorham ED, et al. The role of vitamin D in cancer prevention. Am J Public Health. 2006;96(2):252-261. 32. Gissel T, Rejnmark L, Mosekilde L, Vestergaard P. Intake of vitamin D and risk of breast cancer--a meta-analysis. J Steroid Biochem Mol Biol. 2008 Sep;111(3- 5):195-9. 33. Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, Newmark H, Holick MF, Garland FC. Vitamin D and prevention of breast cancer: pooled analysis. J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):708-11. 34. Plasma Vitamin D Metabolites and Risk of Colorectal Cancer in Women, Di- ane Feskanich et al., Cancer Epidemiol Biomarkers Prev September 1 2004 (13) (9) 1502-1508; 35. Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M, Holick MF. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Am J Prev Med. 2007 Mar;32(3):210-6. 36. Tuohimaa P, Lyakhovich A, Aksenov N, Pennanen P, Syvälä H, Lou YR, Ahonen M, Hasan T, Pasanen P, Bläuer M, Manninen T, Miettinen S, Vilja P, Yli- komi T. Vitamin D and prostate cancer. J Steroid Biochem Mol Biol. 2001 Jan- Mar;76(1-5):125-34. 37. Vitamin D Intake and the Risk for Pancreatic Cancer in Two Cohort Studies Halcyon G. Skinner et al., Cancer Epidemiol Biomarkers Prev September 1 2006 (15) (9) 1688-1695; 38. Walentowicz-Sadłecka M, Sadłecki P, Walentowicz P, Grabiec M. Rola wita- miny D w karcynogenezie raka piersi i raka jajnika [The role of vitamin D in the car- cinogenesis of breast and ovarian cancer]. Ginekol Pol. 2013 Apr;84(4):305-8. Polish. 39. Mizuta T, Ozaki I, Eguchi Y, Yasutake T, Kawazoe S, Fujimoto K, Yamamoto K. The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and sur- vival in patients with hepatocellular carcinoma after curative treatment: a pilot study. Cancer. 2006 Feb 15;106(4):867-72. 40. Nimptsch K, Rohrmann S, Linseisen J. Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am J Clin Nutr. 2008 Apr;87(4):985- 92. 41. https://selfhacked.com/blog/vitamin-d-inflammation-autoimmunity/ 42. Wen H, Luo J, Zhang X, Zhang C, Zhao X, Wang X, Li X. [1,25(OH)2-Vita- min-D3 attenuates Th17-related cytokines expression in peripheral blood mononu-

clear cells in patients with early-diagnosed rheumatoid arthritis]. Zhonghua Nei Ke Za Zhi. 2015 Apr;54(4):317-21. 43. Gopinath K, Danda D. Supplementation of 1,25 dihydroxy vitamin D3 in pa- tients with treatment naive early rheumatoid arthritis: a randomised controlled trial. Int J Rheum Dis. 2011 Oct;14(4):332-9. 44. https://labs.selfdecode.com/blog/35proven-health-benefits-vitamin-d-part-1/ 45. Harms LR, Burne TH, Eyles DW, McGrath JJ. Vitamin D and the brain. Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):657-69. 46. https://selfhacked.com/blog/vitamin-d-brain-health/ 47. Grandner MA, Jackson N, Gerstner JR, Knutson KL. Sleep symptoms as- sociated with intake of specific dietary nutrients. J Sleep Res. 2014;23(1):22-34. doi:10.1111/jsr.12084 48. Evatt ML. Vitamin D associations and sleep physiology-promising rays of in- formation. Sleep. 2015;38(2):171-172. Published 2015 Feb 1. doi:10.5665/sleep.4386 49. Hoang MT, Defina LF, Willis BL, Leonard DS, Weiner MF, Brown ES. As- sociation between low serum 25-hydroxyvitamin D and depression in a large sample of healthy adults: the Cooper Center longitudinal study. Mayo Clin Proc. 2011;86(11):1050-1055. 50. Quesada-Gomez, J.M.; Bouillon, R. Is calcifediol better than cholecalciferol for vitamin D supplementation? Osteoporos Int 2018, 29, 1697-1711. 51. Graeff-Armas, L.A.; Bendik, I.; Kunz, I.; Schoop, R.; Hull, S.; Beck, M. Supple- mental 25-Hydroxycholecalciferol Is More Effective than Cholecalciferol in Raising Serum 25-Hydroxyvitamin D Concentrations in Older Adults. The Journal of Nutri- tion 2020, 150, 73-81.