Bio Vsion - Chi

目录 CONTENT 01 什么是老年性黄斑 变性？ 05 叶黄素和玉米黄质 12 Lutemax® 2020 特殊功能 24 促进眼睛健康的 β胡萝卜素 29 山桑子花青素促 进眼睛健康

www.nhf.com.my 什么是老年性黄斑变性？ | 1

www.nhf.com.my www.nhf.com.my 2 | 什什么是老年性黄斑变性？

www.nhf.com.my www.nhf.com.my 什么是老年性黄斑变性？ | 3

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www.nhf.com.my www.nhf.com.my 6 | 什叶黄素和玉米黄质

www.nhf.com.my 叶黄素和玉米黄质 | 7

Lutein & Zeaxanthin: www.nhf.com.my 8 | 什叶黄素和玉米黄质

叶黄素和玉米黄质 | 9

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www.nhf.com.my Lutemax 2020特殊功能 | 13

www.nhf.com.my 14 | 什Lutemax2020特殊功能

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16 | 什Lutemax2020特殊功能

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18 | 什Lutemax2020特殊功能

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www.nhf.com.my 22 | 什Lutemax2020特殊功能

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www.nhf.com.my 促进眼睛健康的β胡萝卜素 | 25

www.nhf.com.my www.nhf.com.my 26 | 什促进眼睛健康的β胡萝卜素

促进眼睛健康的β胡萝卜素 | 27

www.nhf.com.my 28 | 什促进眼睛健康的β胡萝卜素



www.nhf.com.my 30 | 什山桑子花青素促进眼睛健康

www.nhf.com.my 山桑子花青素促进眼睛健康 | 31

www.nhf.com.my www.nhf.com.my 32 | 什山桑子花青素促进眼睛健康

References 1. https://www.webmd.com/eye-health/macular-degeneration/age-related-mac- ular-degeneration-overview 2. https://www.allaboutvision.com/conditions/amd.htm 3. Gammone MA, Riccioni G, D’Orazio N. Carotenoids: potential allies of car- diovascular health?. Food Nutr Res. 2015;59:26762. 4. Koushan K, Rusovici R, Li W, Ferguson LR, Chalam KV. The role of lutein in eye-related disease. Nutrients. 2013;5(5):1823-1839. 5. Eisenhauer B, Natoli S, Liew G, Flood VM. Lutein and Zeaxanthin-Food Sources, Bioavailability and Dietary Variety in Age-Related Macular Degeneration Protection. Nutrients. 2017;9(2):120. 6. Bernstein PS, Li B, Vachali PP, et al. Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease. Prog Retin Eye Res. 2016;50:34-66. 7. Roberts JE, Dennison J. The Photobiology of Lutein and Zeaxanthin in the Eye. J Ophthalmol. 2015;2015:687173. doi:10.1155/2015/687173 8. Semba RD, et. al., Are lutein and zeaxanthin conditionally essential nutrients for eye health? Med. Hypotheses. 2003, 61 (4): 465-72. 9. Ma L, Dou HL, Wu YQ, Huang YM, Huang YB, Xu XR, Zou ZY, Lin XM. Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis. Br J Nutr. 2012 Feb;107(3):350-9. 10. Mares-Perlman JA, Fisher AI, Klein R, Palta M, Block G, Millen AE, Wright JD. Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. Am J Epidemiol. 2001 Mar 1;153(5):424-32. 11. Vu HT, Robman L, Hodge A, McCarty CA, Taylor HR. Lutein and zeaxanthin and the risk of cataract: the Melbourne visual impairment project. Invest Ophthal- mol Vis Sci. 2006 Sep;47(9):3783-6. 12. Delcourt C, Carrière I, Delage M, Barberger-Gateau P, Schalch W; POLA Study Group. Plasma lutein and zeaxanthin and other carotenoids as modifiable risk factors for age-related maculopathy and cataract: the POLA Study. Invest Ophthal- mol Vis Sci. 2006 Jun;47(6):2329-35. 13. Kowluru RA, Menon B, Gierhart DL. Beneficial effect of zeaxanthin on retinal metabolic abnormalities in diabetic rats. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1645-51. 14. Muriach M, Bosch-Morell F, Alexander G, Blomhoff R, Barcia J, Arnal E, Al- mansa I, Romero FJ, Miranda M. Lutein effect on retina and hippocampus of diabet- ic mice. Free Radic Biol Med. 2006 Sep 15;41(6):979-84. 15. Woo TT, Li SY, Lai WW, Wong D, Lo AC. Neuroprotective effects of lu- tein in a rat model of retinal detachment. Graefes Arch Clin Exp Ophthalmol. 2013;251(1):41-51.

16. Yang SF, Roberts JE, Liu QH, Pang J, Sarna T. Zeaxanthin and Lutein in the Management of Eye Diseases. J Ophthalmol. 2016;2016:4915916. 17. He RR, Tsoi B, Lan F, Yao N, Yao XS, Kurihara H. Antioxidant properties of lutein contribute to the protection against lipopolysaccharide-induced uveitis in mice. Chin Med. 2011;6(1):38. Published 2011 Oct 31. 18. Age-Related Eye Disease Study 2 Research Group. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Dis- ease Study 2 (AREDS2) randomized clinical trial. JAMA. 2013 May 15;309(19):2005- 15. 19. Wu J, Cho E, Willett WC, Sastry SM, Schaumberg DA. Intakes of Lutein, Zeaxanthin, and Other Carotenoids and Age-Related Macular Degeneration During 2 Decades of Prospective Follow-up. JAMA Ophthalmol. 2015;133(12):1415-1424. 20. Kim EK, Kim H, Vijayakumar A, Kwon O, Chang N. Associations between fruit and vegetable, and antioxidant nutrient intake and age-related macular degen- eration by smoking status in elderly Korean men. Nutr J. 2017;16(1):77. Published 2017 Dec 4. 21. Use of vitamin supplements and cataract: the blue mountains eye study, Kuzniarz, Maciek et al. American Journal of Ophthalmology, Volume 132, Issue 1, 19 - 26 22. Gizzi C, Belcaro G, Gizzi G, Feragalli B, Dugall M, Luzzi R, Cornelli U. Bil- berry extracts are not created equal: the role of non anthocyanin fraction. Discover- ing the “dark side of the force” in a preliminary study. Eur Rev Med Pharmacol Sci. 2016 Jun;20(11):2418-24. PMID: 27338070. 23. Shim SH, Kim JM, Choi CY, Kim CY, Park KH. Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glau- coma. J Med Food. 2012;15(9):818-823. 24. Ozawa Y, Kawashima M, Inoue S, Inagaki E, Suzuki A, Ooe E, Kobayashi S, Tsubota K. Bilberry extract supplementation for preventing eye fatigue in video dis- play terminal workers. J Nutr Health Aging. 2015 May;19(5):548-54. 25. Yao N, Lan F, He RR, Kurihara H. Protective effects of bilberry ( Vaccinium myrtillus L.) extract against endotoxin-induced uveitis in mice. J Agric Food Chem. 2010 Apr 28;58(8):4731-6. 26. Miyake S, Takahashi N, Sasaki M, Kobayashi S, Tsubota K, Ozawa Y. Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cel- lular and molecular mechanism. Lab Invest. 2012 Jan;92(1):102-9. 27. Aly EM, Ali MA. Effects of bilberry on deoxyribonucleic Acid damage and oxidant-antioxidant balance in the lens, induced by ultraviolet radiation. Malays J Med Sci. 2014;21(1):11-18. 28. Yu M, Yan W, Beight C. Lutein and Zeaxanthin Isomers Protect against Light-Induced Retinopathy via Decreasing Oxidative and Endoplasmic Reticulum Stress in BALB/cJ Mice. Nutrients. 2018; 10(7):842. 29. Nicole T. Stringham, Philip V. Holmes, James M. Stringham, Effects of mac- ular xanthophyll supplementation on brain-derived neurotrophic factor, pro-in-

flammatory cytokines, and cognitive performance, Physiology & Behavior, Volume 211,2019. 30. Yu M, Yan W, Beight C. Lutein and Zeaxanthin Isomers Reduce Photorecep- tor Degeneration in the Pde6brd10 Mouse Model of Retinitis Pigmentosa. Biomed Res Int. 2018 Dec 17;2018:4374087. 31. Hammond BR, Fletcher LM, Roos F, Wittwer J, Schalch W. A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on photostress re- covery, glare disability, and chromatic contrast. Invest Ophthalmol Vis Sci. 2014 Dec 2;