MedTech Manufacturing Alliance (MTMA)

MedTech Manufacturing Alliance Co-Innovate. Co-Create. Co-Translate. .

What is MedTech Manufacturing Alliance — The MedTech Manufacturing Alliance is a collaborative platform represented by A*STAR research institutes (RIs), institutes of higher learning (IHLs), original equipment manufacturers (OEMs), global medical equipment providers as well as SMEs. Through the membership ecosystem, the alliance aims to develop R&D solutions based on real problem statements in the medical and healthcare industry to shape the future of societal healthcare in Singapore. ​ Our Vision​ To be the catalyst of choice for Singapore’s MedTech Manufacturing ecosystem in research and innovation of medical and healthcare products and solutions Our Mission​ To strengthen Singapore’s leadership position as an end-to-end hub for MedTech Manufacturing in research and innovation through collaboration with local SMEs, LLEs, MNCs and public agencies 2- MedTech Manufacturing Alliance

Co-INNOVATE​ Co-CREATE​ We connect and work with Every partnership is unique. our stakeholders to innovate, Our ecosystem emphasises differentiate and compete building strategic partnerships successfully in the MedTech and collaboration with our Manufacturing domain​. stakeholders to grow and achieve together as one​. Co-TRANSLATE​ MedTech Manufacturing Alliance - 3 Our business model focuses on the translation of research to innovation and enterprise to develop compelling solutions for economic, societal and health impact.

05. ABOUT US 06. PURPOSE 07. OUR FOCUS AREAS —Smart Manufacturing 08 —Diagnostic & Remote Monitoring 09 —Laboratory Automation Robotics 10 12. ADDRESSING NATIONAL PRIORITIES —Ageing-Related Healthcare 13 —COVID-19 MedTech Innovations 14 15. JOIN US! 4- MedTech Manufacturing Alliance

About Us MedTech Manufacturing Alliance - 5 Creating Impact through Synergy SIMTech and ARTC are two research institutes under the Agency for Science, Technology and Research (A*STAR) operating on complementary business models. Assimilating unique individual strengths, the collaboration between SIMTech and ARTC leverages on positive synergies and assembles varied talents to form a pool of different skills and knowledge to translate research into industrial applications through close collaboration. Together, SIMTech and ARTC aim to drive business growth in Singapore and to uplift local competitiveness in the MedTech Manufacturing industry. SIMTech Singapore Institute of Manufacturing Technology (SIMTech) aims to be a world-class innovation partner in advanced manufacturing technologies, systems, and capabilities. It develops targeted high-value manufacturing technologies and human capital to enhance the competitiveness of Singapore’s manufacturing industry, and is committed to developing the human, intellectual, and industrial capital in Singapore. SIMTech collaborates with multinational and local companies, public agencies, and institutes of higher learning in the precision engineering, MedTech, aerospace, automotive, marine, oil & gas, electronics, semiconductor, and logistics sectors, among others. ARTC Advanced Remanufacturing and Technology Centre (ARTC) is a collaboration platform built upon strong public-private partnerships. In partnership with Nanyang Technological University, Singapore (NTU Singapore), ARTC has a membership consortium with over 80 members, ranging from global multinational corporations (MNCs), public agencies, small and medium enterprises (SMEs) to startups focusing on three core industry clusters – Energy & Infrastructure, Transport & Engineering, and Consumer & Modern Services. ARTC’s expertise in advanced manufacturing and remanufacturing accelerates the transfer of innovation from applied research to industrial applications and solutions.

Purpose Seeking to change Transforming our world for ideas into potential the better with opportunities for a relentless growth and market innovative spirit. expansion. Embracing creative Spearhead Discover and continuous Innovation Market improvement in our Opportunities R&D translational work. Deliver Societal Impact 6- MedTech Manufacturing Alliance Creating a positive influence towards the local community and public services of healthcare in Singapore.

Three Focus Areas Smart Manufacturing – 1 A Seamless Automated Manufacturing Operation Process Diagnostic and Remote 2 Monitoring – Bringing Healthcare To People Laboratory Automation 3 MedTech Manufacturing Alliance - 7 - Empowering Global Health Through Impactful Innovation

Smart Manufacturing A Seamless Automated Manufacturing Operation Process Harnessing the benefits of Industry 4.0 technologies such as robotics, automation, artificial intelligence and machine learning, manufacturing operations in smart factories relieve manpower shortage and improve manufacturing performance. Automation & digitalisation will stimulate manufacturing transformation and help companies on their journey to drive sustainable processes, elevate competitiveness and enable resilience. 8- MedTech Manufacturing Alliance

Diagnostic & Remote Monitoring Bringing Healthcare To People Point-of-care diagnostics can play a powerful role in patient care, enabling more rapid clinical decision-making in the process of diagnosis, treatment choice and monitoring, and prognosis. We work with innovative companies seeking to bring novel solutions in developing remote monitoring for chronic care and testing for infectious diseases. Together, our development efforts aim to achieve a future with high-quality patient care and lower costs. MedTech Manufacturing Alliance - 9

10- MedTech Manufacturing Alliance Laboratory Automation & Robotics Empowering Global Health Through Impactful Innovation In Labs We are dedicated to creating a future where handling of lab processes is automated with minimal touch points, and lab results are automatically traced from start to finish throughout the diagnostics processes in a connected lab environment. Our innovation concentrates on utilising state-of-the-art technology such as 5G, augmented reality, virtual reality, process robotisation and lab diagnostics sample handling automation to build a lab of the future. RAVE & BRAVE • A collaboration between SIMTech, ARTC, Diagnostic Development Hub (DxD) and industry partners (Rave – Sankei, Brave – KA industrial) • Automates some of the manual steps usually required in sample processing, such as uncapping of tubes and pipetting • Leverages on Industry 4.0 technologies such as the custom-built robotic and automation systems • December 2021: Deployed in 5 laboratories and achieved more than 2 million COVID-19 tests • Minimises human error, reduces contamination and infection risks for laboratory staff • Accurate, reliable and high throughput testing processes within a safer environment Social Impact • Supports the need to step up testing efforts in Singapore • Prevents infection risks and reduces fatigue in laboratory staff due to manual workload “Over the years, A*STAR has built deep capabilities in molecular biology, diagnostic testing, robotics, and smart sensing, that have enabled SDL to be set up” Prof Patrick Tan, Founding Programme Director of SDL, and Executive Director of A*STAR’s Genome Institute of Singapore (GIS)

AVID MedTech Manufacturing Alliance - 11 • A collaboration between SIMTech, ARTC and Sysmatic Global • An automated system to replace the manual step of extracting vaccines from vials to syringes • Addresses the labour-intensive steps of the vaccination process while reducing handling of sharp syringes • Reduces risks of cross-contamination and vaccine wastage due to safe handling by the machine • December 2021: Supported up to 200,000 vaccinations Social Impact • Aiding Singapore’s efforts in supporting healthcare workers by reducing workload and fatigue levels of healthcare workers • Increases overall safety for healthcare workers “The A*STAR team was very helpful and provided us with a lot of information very quickly. These are the things that we learn from them as a small and medium-sized enterprise, something which we would not have been able to do by ourselves.” Mr Khoo Kiak Nee, Director of Sysmatic Global

12- MedTech Manufacturing Alliance Addressing National Priorities COVID-19 MedTech Innovations Ageing-Related Healthcare

Ageing-Related Healthcare Median Age of Healthy Longevity Singapore Residents Characterised by chronic illnesses such as cancer, 2000 2021 Alzheimer’s disease, and cardiovascular diseases, ageing MedTech Manufacturing Alliance - 13 - - has evolved to become one of the greatest risk factors. As our elderly population advances in years, they have 34.0 41.8 become more susceptible to these diseases. Long-term care for the elderly has become one of the most daunting healthcare challenges. Ageing population is one of the key issues in Singapore. The median age of Singapore residents has increased from 34.0 in 2000 to 41.8 in 2021¹. To address this problem, Singapore has taken a multifaceted, integrated and holistic approach to meet the needs of the elderly population. The approach will focus on home and community-based care which is preferred by many elderly and will optimise resources in Singapore for other purposes. Aligned with the approach, our innovation efforts focus on tackling these challenges by working with companies whose intention is to delay these age-related diseases, and researching homecare robotic and monitoring systems where the elderly can participate in self-care. We look to co-innovating with partners in mobility assistance, fall prevention, rehabilitation care and wearable diagnostics where the quality of life for our elderly in Singapore can be significantly improved. Through securing healthy longevity and preventing chronic age-related diseases, we strive to build a future where our elderly can age confidently and gracefully in Singapore. ¹ Source: Department of Statistics Singapore - Population Trends 2021 (https://www.singstat.gov. sg/-/media/files/publications/population/population2021.pdf)

COVID-19 MedTech Innovations Catalysing Translational R&D to Combat the Pandemic When COVID-19 hit Singapore in 2019, a strong team of multi-disciplinary researchers from A*STAR came together to collaborate with the Diagnostic Development Hub (DxD), National Environment Agency (NEA), Ministry of Health (MOH), as well as industry partners such as Ramatex, KA Industrial, Sankei Eagle, Advanced MedTech and Sysmatic Global to support Singapore’s initiatives in battling the pandemic. Industry 4.0 technologies were mobilised to innovate and translate solutions to safeguard the health and well-being of our community as well as to assist our laboratory staff and healthcare workers in their work. Ramatex 5 Wastewater Masks Automated Valence COVID-19 Engine (WAVE) Reusable face masks which are washable Solutions An automated liquid handling system for NEA’s up to thirty times, diagnostic process to extract COVID-19 virus qualified by TÜV SÜD. genetic signatures from wastewater samples. RAVE (Rapid BRAVE, BRAVE+ AVID (Automated Automated Volume (Bio Rapid Automated Vaccine Inoculation Enhancer) Valence Engine) Dispenser) A robotic lab system that automates BRAVE encompasses the same A robotic system that automates the uncapping of tubes and pipetting to features as RAVE with a much faster extraction of vaccines from vials plus help save time, manpower and costs and larger-scale COVID-19 testing disperses bubbles inside the syringes, in sample processing for Polymerase capability such as barcode scanning using a combination of robotic parts, Chain Reaction (PCR) testing. for sample identification, and smart sensors and digital technologies. automated handling of test samples for PCR testing. 14- MedTech Manufacturing Alliance Fast forward, Singapore has emerged stronger, more resilient and more ready to live with the virus in the midst. With plans to treat COVID-19 as an endemic, Singapore is seeking to pursue a strategy of “living with COVID-19”. Understanding that the journey will not be smooth and easy, Singapore will need to stay vigilant and adapt to any arising situation by preparing our healthcare system for more twists and turns or the emergence of a new disease. Disease X is not a matter of if, but when. Singapore will continue to stay nimble and learn as we strengthen our resilience against Disease X through the investment of R&D in science and technology. Our researchers remain committed to sustaining basic research and broadening research foundations with a key focus on biomedical science, health and human potential while collaborating with industry partners to co-innovate and co-translate these research into industrial solutions.

Join Us! on this collaborative journey MedTech Manufacturing Alliance - 15

Partner Global Ensure Safe Gain Market Environment Opportunities Industry Members — — — Leverage a safe working environment Generate new ideas and transform Gain access to a wide array through ensuring high-quality health these ideas into opportunities for of professional networking and safety international standards growth through market penetration, opportunities from ARTC’s with our R&D facilities to eliminate market development, product consortium and SIMTech’s industry any hazards, exposures and risk. development and diversification. partners. Be invited to forums. Tap on multi-disciplinary research for collaborative industry projects and cross-sectorial collaboration. 16- MedTech Manufacturing Alliance De-Risk Transfer Knowledge & Obtain First-Hand Investments Skillsets Feedback & Commercial Consideration — — — Test process improvements enabled Our collaborative platform is where by the technologies in our facilities ideas turn into reality. Power up Feedback is the greatest source of without disrupting your operations on technological platforms! We will learning. Obtain first-hand to achieve results faster with low provide you with the necessary feedback from our existing member investment risks. tools, support and training to base to continuously improve transfer technology into industrial and determine the possibility of application. commercialisation.

Business Model The MedTech Manufacturing Alliance is a new pillar under the ARTC Consortium Membership model. The tripartite business model will forge a robust collaboration partnership with our members in the MedTech Manufacturing Alliance membership ecosystem. Members can benefit from the pooled research resources and best-in-class knowledge to achieve technology capabilities faster by addressing common industrial problems. The pyramid illustrates the mechanism of synergy between the membership ecosystem. The anchor and tier 1 members provide problem statements reflecting real industry needs to the technology service providers and SMEs. Through close collaboration, SIMTech and ARTC will drive innovation efforts with these solution providers to create compelling solutions that resolve the problem statements for the industry and serve to establish a robust MedTech Manufacturing ecosystem in Singapore. Membership Tier ANCHOR Anchor & Tier 1 & TIER 1 Tier 2 Tier 3 Real Industry Achieves Industrial MedTech Manufacturing Alliance - 17 Needs Solutions in A Faster SOLUTIONS & Cheaper Way NEEDS TECHNOLOGY & SERVICE PROVIDERS Engage SMEs Equipment Optimised for Support for Future Applications SMALL & MEDIUM ENTERPRISES Expand Service Engineering Support or Provisons to Members Customised Auxiliary Equipment CORE/JOINT PROJECTS MEMBER-SPECIFIC PROJECTS • Solving common industrial • Directed by individual members problems through cost-sharing for their specific applications • Creating and sharing best-in-class • Bilateral (e.g. OEM+ARTC), knowledge Tripartite (e.g. OEM, Supplier, ARTC), etc. • Early co-development with supply chain

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(65) 6590 3199 [email protected] www.a-star.edu.sg/ARTC/mtma MedTech Manufacturing Alliance - 19