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“I thought I was Eliminated Rx going to have Off all diabetes drugs type 2 diabetes until the day I died.” Reduced A1c from 6.5% to 5.5% Tim Lost 100 lbs Virta patient since 2017 and resolved fatty liver Learn more about reversing diabetes at virtahealth.com [email protected]

Virta empowers people to reverse type 2 diabetes safely and sustainably diabetes reversal Medical Spend 60% $10,400 Patients that achieve sub-diabetic Two-year cost savings per patient, based on A1c and eliminate all diabetes- claims analysis by independent actuary. specific medications after one year1 Rx Cost Reduction Under standard care, 63% annual incidence of remission of diabetes Average diabetes Rx cost reduction at one year based on peer-reviewed clinical data. is <1%2 1. Hallberg SJ et al. Diabetes Therapy. 2018;9(2):583-612. For patients completing 1 year of treatment. Virta Health Registry for Remote Care of Chronic Conditions. Health and economic outcomes as of March 2019 2. Karter, Andrew J et al. ”Incidence of remission in adults with type 2 diabetes: the diabetes & aging study.” Diabetes care vol. 37,12 (2014): 3188-95. doi:10.2337/dc14-0874

Our fees are 100% at risk Three performance guarantees Bill through claims A1c Target Virta is a medical provider, so we can work with your health plan to bill 1.0 Reduction through claims. Because of this, we do not affect your administrative budget. Weight Target 2:1 ROI over 24 months 5% Weight Loss Cost savings are direct and Diabetes Rx Target realized rapidly due to removal of costly diabetes medications. 40% Cost Reduction What you don't pay for Implementation Non-participants Engagement

Our mission is to reverse type 2 diabetes in 100 million people by 2025 we believe Everyone deserves the opportunity to reverse their chronic metabolic disease. The combined power of nutritional science and advanced telehealth can deliver breakthrough outcomes. The sucess of a healthcare solution should be measured in outcomes, not efforts.

Top Industry Leaders Believe in Virta Alan Moses, MD Francine Kaufman Don Berwick, MD, MPP, FRCP Former Chief Medical Officer of Former President of the Former Administrator of the Centers Novo Nordisk American Diabetes Association for Medicare and Medicaid Services “The health outcomes Virta “The growing diabetes epidemic “What Virta does probably delivers for people with type 2 has to be met with strategies more effective than any system diabetes are unmatched, and to reverse this disease. that I’ve seen is their ability particularly noteworthy for the to help people get back into level of control achieved while Comprehensive continuous proper metabolic balance to eliminating medications. remote care programs like feel more in control of their life. Virta, aimed at the root cause, Virta’s care delivery model has are essential.” Virta has taught us a new way transformational potential.” to think about diabetes.”

Move beyond years of managing diabetes… For decades, type 2 diabetes has been treated as a from low-cost generics, like metformin, to higher cost chronic and progressive disease. Physicians are taught branded medications, and ultimately to insulin. to address heightened A1c with increasingly aggressive For payers, this pattern has played out so consistently, (and expensive) prescription drugs. Over the course of and for so many millions of patients, that diabetes drugs several years in treatment, a typical patient will migrate now represent a top three pharmacy cost driver. Years 8.0% Uncontrolled 6.5% Diabetes 5.7% Prediabetes A1c 0 2 4 6 8 10 $100 $2–3K $4–6K $6–10K $10K+ Oral Generics Branded Orals Branded Injectables Branded Orals Aggressive Insulin + Insulin (Metformin) (SGLT-2, DPP-4) (GLP-1)

…to reversing diabetes, often in a matter of weeks. Through the Virta treatment, patients now have a In fact, 94% of patients taking insulin reduce or choice—instead of managing diabetes with drugs, completely eliminate usage at one year, with much they may choose to reverse it completely. Virta helps of these reductions occurring within weeks. 60% patients reduce their blood sugar below the diabetes of patients at one year are off all diabetes-specific threshold, while simultaneously discontinuing the use drugs. From the patient's perspective, they are living of costly drugs. diabetes-free. Weeks 8.0% Uncontrolled 6.5% Diabetes 5.7% Prediabetes A1c 05 10 15 20 25+ $10K $7K $3K $100 ~$0 Aggressive Rx Rapid De-Prescription Process Off All Diabetes Rx

HOW IT WORKS Nutritional therapy Advanced telehealth reduces blood sugar and ensures engagement and dependence on medications sustainability Intensive Human and App-Based Coaching Daily Remote Monitoring of Biomarkers Physician-Led De-Prescription of Medication Nutritional approach has been cited in the Unique telehealth model based on continuous American Diabetes Association Standards of patient engagement delivers retention rates of Medical Care in Diabetes, three years running. 83% at one year. Hallberg SJ et al. Diabetes Therapy. 2018;9(2):583-612.

Meet the Virta care team Caroline Roberts, MD Robert E. Ratner, MD, FACP, FACE Catherine Metzgar, PhD, MD Virta Physician Chief Medical Officer, Virta Virta Health Coach Board-Certified Endocrinology Former Chief Medical Officer, ADA* “Since joining Virta I’ve spent the “Virta is pushing a tectonic shift in “Our patients have access to last few years helping patients diabetes care. I’ve always pursued their health coach team at their reverse their diabetes, regain the most effective and evidence fingertips. energy, and feel better. based ways to treat and prevent type 2 diabetes. We are truly partnering as a Virta is the only company with team to celebrate wins, navigate scalable method to help patients I’ve always followed the data. challenges, and personalize the reverse type 2 diabetes safely It is this pursuit that led me to Virta Treatment based on patient and sustainably.” Virta Health.” goals and preferences.” * American Diabetes Association

Virta Treats the Full Spectrum of Diabetes and Related Conditions HbA1c Diabetes Reversal Path to Reversal 6.5 and Safely de-prescribe diabetes medications and return For patients who are not above blood sugar to subdiabetic levels. ready to reverse diabetes For patients with type 2 diabetes, ready to reverse. yet, we provide best-in-class Between diabetes care combined with 5.7 and 6.5 Diabetes Management gentle nudges to reversal. Less Monitor and control blood sugar, provide than 5.7 behavioral counseling & nudges to reversal. For patients with type 1 or type 2 diabetes, not ready to reverse. Prediabetes Reversal Return blood sugar to sub-prediabetic levels and deliver clinically significant weight loss. For patients with prediabetes (A1c between 5.7 and 6.5). Obesity Treatment Deliver clinically significant weight loss of 5–12% for patients struggling with obesity. For patients with BMI > 30.

The Reversal Advantage The value of Virta is clear to both payers and patients, especially when you compare our average outcomes with what is possible with the leading diabetes drugs. We deliver results that compare to or even exceed existing pharmacological therapies—while simultaneously removing the need for these drugs. Virta Health Insulin GPL-1 DPP-4 SGLT-2 A1c -1.3 -1.8 -1.2 -0.7 -0.7 Reduction Weight -30 lbs +3.9 lbs -4.4 lbs 0 lbs -4.4 lbs Change Rx Cost -$160 $365 $720 $380 $400 Per Month Hallberg SJ, et al. Effectiveness and Safety of a Novel Care Model for the Management of Type 2 Diabetes at One Year. Diabetes Therapy. 2018; 9(2): 583-612; Third-Line Pharmacotherapy for Type 2 Diabetes. CADTH Optimal Use Report, No. 3.1B3.

Virta is reversing the progression of type 2 diabetes After just one year, our clinical trial showed a 3.5x increase in the percentage of patients with an A1c below the diabetes threshold, while also dramatically reducing the percentage of patients with uncontrolled diabetes. A1c Population Distribution Baseline 21% 41% 19% 20% < 6.5 A1c 6.5—7.4 < 7.5—8.4 > 8.5 A1c after 72% 18% 7% 3% 1 year Hallberg SJ, et al. Effectiveness and Safety of a Novel Care Model for the Management of Type 2 Diabetes at One Year. Diabetes Therapy. 2018; 9(2): 583-612. Note: where laboratory values for HbA1c were not available, HbA1c was estimated based on a validated statistical model, with a median absolute error of 0.23.

Health improvements are sustainable long-term 83% “When it comes to reporting outcomes, 15–30% Retention many diabetes vendors make big promises Virta is leading a 5-year clinical trial in order at 1 year that do not stand up to close analytical to demonstrate that diabetes reversal is not Typical Behavioral scrutiny. Virta is the first and only diabetes just transformative, it is sustainable. Program Retention treatment to meet Validation Institute’s high bar for delivering clinical outcomes that are To date, we have published both 1- and 2-year at 1 year both transformational and verifiable.” results showing sustained levels of retention, as well as sustained outcome improvements Martin CK. Int J Obesity. 2010 Apr; 34(4): 742-750; RD Whitney around blood sugar, prescription drug cost, Virta Health Registry for Remote Care of Chronic Conditions. CEO, Validation Institute and weight loss. Peer-reviewed research DDiiaabbeetteessDDrruuggCClalsasssElEimliminiantaiotnion Usual Care Virta Health % - Long-term prediabetes reversal % and T2D prevention %% Nutrients, 2021 % - Long-term T2D reversal -% Frontiers in Endocrinology, 2019 -% - Sustained improvement in cardiovascular risk factors -% -% Cardiovascular Diabetology, 2018 -% Year - Sustained improvement markers -% Weeks -% of liver disease Baseline Years BMJ Open, 2019 Hallberg SJ et al. Diabetes Therapy, 2018. Athinarayanan SJ et al. Frontiers in Endocrinology, 2019. - Rapid impact on type 2 diabetes Percentages indicate change in the number of distinct diabetes-specific drug classes prescribed per patient, on average. JMIR Diabetes, 2017 - Improved sleep quality Sleep Medicine, 2019 For additional research, visit virtahealth.com/research