Infinilife International Sdn Bhd INFINIYOUNG
Health Supplement Product
N-CEL 1 • Cleance Research shows some of the benefits of N-Cel 1 ~Maintain cellular energy ~Helps the liver detoxification process ~Helps liver cells repair ~Prevent free radical damage ~Anti aging
INGREDIENT 01 02 03 CONTENT Hightlight Go Green Additional Pieces NMN Alfalfa Wheat grass Green tea Mix Vegetable Pandan Bitter Melon
01 Highlight Nicotinamide Mononucleotide
Nicotinamide Mononucleotide Nicotinamide mononucleotide (NNM) is an orally bioavailable NAD+ precursor, while NAD+ regulates various biological processes, such as metabolism, DNA repair, gene expression, and stress responses that are tightly related to the aging process. With oral administration of NMN (250mg/ day) in 15 healthy volunteers, the NAD+ levels were significantly increased at 4-, 8-, 12 weeks. In addition, NMN is safe for consumption with no abnormalities in physiological and laboratory tests, and no obvious adverse effects were observed for 12 weeks. Okabe, K., Yaku, K., Uchida, Y., Fukamizu, Y., Sato, T., Sakurai, T., Tobe, K. and Nakagawa, T., 2022. Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects. Frontiers in Nutrition, 9.
02 Go Green Alfalfa Wheat grass Pandan
Alfalfa Nobel Prize winner, Dr. Richard Willstatter The structural similarities between chlorophyll and haemoglobin may help to increase the oxygen level in our body and supply cells with sufficient oxygen Also, high in vitamin K which is needed to produce prothrombin for proper blood clotting
Anti-inflammatory effect of Wheat Grass RAW 264.7 cells treated with lipopolysaccharide (LPS) demonstrated a significant increased level (60 μM) of nitric oxide (NO) in the culture media as compared to control. In the presence of 5-day old wheatgrass (W5), the level of NO production dropped to 42 and 18 μM at 100 and 200 μM concentrations of W5, respectively. A similar condition was observed with 7-day old wheatgrass (W7) as the level of NO production reduced to 38 and 20 μM at 100, and 200 μM concentrations of W7 respectively. Thus, wheatgrass possesses anti-inflammatory effect. Banerjee, S., Katiyar, P., Kumar, V., Waghmode, B., Nathani, S., Krishnan, V., Sircar, D. and Roy, P., 2021. Wheatgrass inhibits the lipopolysaccharide-stimulated inflammatory effect in RAW 264.7 macrophages. Current research in toxicology, 2, pp.116-127.
Dual Actions of Pandan Metabolic Digestive ü Reduce fever ü Relieve flatulence ü Lower ü Help for indigestion ü Mild laxative effect inflammation ü Manage blood sugar level
03 Additional Pieces Green tea Mix Vegetable Bitter Melon
Anti-inflammatory effect Concentration % inhibition % inhibition of Green Tea (μg/mL) (Green Tea) (Black Tea) Control - - 31.25 220 140 62.5 320 180 80 620 220 250 1100 700 500 2480 1540 1000 4980 2480 Denaturation of the tissue proteins is one of the causes of inflammatory. The in vitro anti-inflammatory effect of green tea and black tea was evaluated against denaturation of egg albumin. Green tea showed higher percentage of protein denaturation inhibition as compared to black tea in the concentration range of 31.25 to 1000 μg/mL. Thus, green tea gives higher anti-inflammatory effect. Chatterjee, P., Chandra, S., Dey, P. and Bhattacharya, S., 2012. Evaluation of anti-inflammatory effects of green tea and black tea: A comparative in vitro study. Journal of advanced pharmaceutical technology & research, 3(2), p.136.
Clinical Trial of Bitter Melon on Diabetes Clinical Trial 1 Clinical Trial 2 24 adults with diabetes showed that 40 people with diabetes taking 2,000 taking 2,000 mg of bitter melon per mg per day of bitter melon for 4 weeks day decreased blood sugar and showed a modest reduction in blood hemoglobin A1c after 3 months. sugar levels and significantly reduced It also increased the first phase and fructosamine levels from baseline total insulin secretion Cortez-Navarrete, M., Martinez-Abundis, E., Perez-Rubio, K.G., Gonzalez-Ortiz, M. and Méndez-del Villar, M., 2018. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. Journal of medicinal food, 21(7), pp.672-677. Fuangchan, A., Sonthisombat, P., Seubnukarn, T., Chanouan, R., Chotchaisuwat, P., Sirigulsatien, V., Ingkaninan, K., Plianbangchang, P. and Haines, S.T., 2011. Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients. Journal of ethnopharmacology, 134(2), pp.422-428.
6 Main Health Benefits of Vegetables Heart Blood sugar Cancer o Research studies showed that Researchers found that o Protection against consumption of green leafy consumption of a vegetarian vegetables was associated with cancers diet was associated with a lower risk of diabetes. lower blood pressure. o Rich in phytoconstituents o Green vegetables were most that can reduce inflammation & cellular strongly associated with damage decreased risk of cardiovascular disease. Gastrointestinal Eyes o Solidify the stool and prevent Lutein, zeaxanthin and other eye-protecting carotenoids to constipation prevent cataracts and macular degeneration o Keep a good balance and diversity of gut bacteria o 70% of immunity from digestive system
N-CEL 2 • Replenish Research shows some of the benefits of N-Cel 2: ~Boost respiratory wellness & relieve respiratory inflammation ~Loaded with antioxidants ~Boost immune system ~Slow down aging and maintain youth ~Skin reproduction ~Maintain cellular energy ~Prevent free radical damage
Ingredient Content 01 02 Highlights Berry Crush Tiger milk mushroom and Elderberry, Acai Berry, Blueberry, Nicotinamide mononucleotide Cranberry, Maqui Berry, Hawthorn Berry 03 Enhancement Dates, Loquat, Pomegranate and Gac
01 Highlight Tiger milk mushroom and Nicotinamide mononucleotide
Tiger Milk Mushroom Rich in Selenium, potassium, thiamine (vitamin B1), riboflavin (vitamin B2), niacin and vitamin D Can be considered as an alternative/ natural medicine o Lungs strengthening and restoration (manage asthma and chronic lungs diseases) o Modulate body immunity which scientifically proven with anti-tumour, anticancer, anti-inflammatory and antioxidant activities o Restore & generate immunity, fight and prevent the spread of cancer cells
Antioxidant content of Tiger Milk Mushroom Sample Total Phenolic Content (mg GAE/g extract) Hot water extract Cold water extract Methanol extract Wildtype 37.52 ± 0.23 31.15 ± 0.61 45.42 ± 0.35 Cultivar 8.07 ± 0.51 12.17 ± 0.10 6.25 ± 0.18 The wildtype of Tiger Milk Mushroom showed higher total phenolic content as compared to the cultivated strain in all types of extraction. The antioxidant activity of Tiger Milk Mushroom was measured and analyzed in comparison with rutin. It is noteworthy to mention that both strains (wildtype and cultivar) exhibited significantly higher superoxide anion radical scavenging activity when compared to rutin. Yap et al., 2013. Nutrient composition, antioxidant properties, and anti-proliferative activity of Lignosus rhinocerus Cooke sclerotium. Journal of the Science of Food and Agriculture, 93(12), pp.2945- 2952.
Nicotinamide Mononucleotide Nicotinamide mononucleotide (NNM) is an orally bioavailable NAD+ precursor, while NAD+ regulates various biological processes, such as metabolism, DNA repair, gene expression, and stress responses that are tightly related to the aging process. With oral administration of NMN (250mg/ day) in 15 healthy volunteers, the NAD+ levels were significantly increased at 4-, 8-, 12 weeks. In addition, NMN is safe for consumption with no abnormalities in physiological and laboratory tests, and no obvious adverse effects were observed for 12 weeks. Okabe, K., Yaku, K., Uchida, Y., Fukamizu, Y., Sato, T., Sakurai, T., Tobe, K. and Nakagawa, T., 2022. Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects. Frontiers in Nutrition, 9.
02 Berry Crush Elderberry, Acai Berry, Blueberry, Cranberry, Maqui Berry, Hawthorn Berry
Antiviral effect of Elderberry Symptoms improvement scores in placebo and elderberry groups 12 No. of patients using rescue med. in placebo and elderberry groups 10 Improvement score 8 Type of medication Placebo Elderberry 6 Placeb o Nasal Spray 21 5 4 Elderberry 2 Painkiller 26 7 0 2 3 4 5 6 7 8 Day The symptoms improvement scores for the elderberry group showed a pronounced improvement (score nearer to 10) after a mean (± SD) of 3.1 ± 1.3 days, while a similar score was obtained after 7.1 ± 2.5 days in the placebo group. The usage of rescue medications was significantly less (P < 0.001) in the elderberry group compared with the placebo group. Zakay-Rones et al., 2004. Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections. Journal of International Medical Research, 32(2), pp.132-140.
Vision Protective Activity of Blueberry Under the light exposure, the blueberry anthocyanin extract was able to increase the viability of retinal pigment epithelium cells and significantly reduce the percentage of aged cell as compared to positive control (without blueberry anthocyanins extract treatment) Liu et al., 2012. Blueberry anthocyanins: protection against ageing and light-induced damage in retinal pigment epithelial cells. British journal of nutrition, 108(1), pp.16-27.
Berries Combo Hawthorn Berry Maqui Berry Effective in protecting heart, Rich in anthocyanin reducing anxiety and it aids Anti inflammatory effect digestion Gives us a healthier heart Cranberry Acai Berry Antibacterial effect for Enhance memory treating/ preventing urinary Reduce inflammatory cytokine tract infection (UTI) TNF-α to improve brain health
03 Enhancement Dates, Loquat, Pomegranate and Gac
Pomegranate Helps for lowering inflammation Contains Punicalagins and Punicic Acid markers (interleukin 6) and In clinical study, people with heart preventing the formation of plaques disease were given 1 cup (220 mL) of in the brain to prevent Alzheimer’s pomegranate juice daily for 5 days disease. which significantly reduced the frequency and severity of chest pain. Dates
Gac fruit Rich in beta carotene Momordica cochinchinensis Mice fed with loquat and high-fat diet had Rich in carotenoids, eg. β-Carotene, lower blood sugar, triglyceride, and insulin levels than mice only on a high-fat diet in 4 lycopene, and lutein weeks. Protect skin from sunlight and radical Another study found that loquat fruit extract Based on clinical study on 185 children, it reduced overall inflammation caused by a high-sugar diet promotes good eyesight, especially in low light. Loquat
N-CEL 3 Strengthen Research shows some of the benefits of N-Cel 3 : ~Strengthen the skin barrier protection ~Promote wound healing ~Boost structural support(muscles and joints) ~Whitening: lighten scars and Dark spot ~Enhance elasticity and firmness to reduce wrinkles and fine line ~Improve skin problems(eg. inflammation) ~Decrease wrinkles & improve skin hydration ~Aging Reverse ~Repairs skin collagen and elastin protein fibers and produces a significant thickening of the outer skin surface (epidermis).
INGREDIENT CONTENTS 01 ANTI-AGING 03 BOOSTER Collagen, Snow lotus, Raspberry, Soy Peptide, Tremella, Turmeric, Red Micro Algae, NMN Blueberry 02 REJUVENATE Bird Nest Peptide, Lemon, Vitamin C , Sakura Flower, Apple stem cells
01 ANTI-AGING Collagen, Snow lotus, Raspberry, Red Micro Algae, NMN
Nicotinamide Mononucleotide Nicotinamide mononucleotide (NNM) is an orally bioavailable NAD+ precursor, while NAD+ regulates various biological processes, such as metabolism, DNA repair, gene expression, and stress responses that are tightly related to the aging process. With oral administration of NMN (250mg/ day) in 15 healthy volunteers, the NAD+ levels were significantly increased at 4-, 8-, 12 weeks. In addition, NMN is safe for consumption with no abnormalities in physiological and laboratory tests, and no obvious adverse effects were observed for 12 weeks. Okabe, K., Yaku, K., Uchida, Y., Fukamizu, Y., Sato, T., Sakurai, T., Tobe, K. and Nakagawa, T., 2022. Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects. Frontiers in Nutrition, 9.
Collagen boosts skin hydration, elasticity & roughness At T12, the mean skin hydration of the test group was significantly increased, by 28.0% ± 11.5%, while the increase in the placebo group was limited to 9.0% ± 6.6%. At T12, skin elasticity was increased in the test group by 0.81 ± 0.04 AU. For skin roughness, the difference of wrinkle depth was four times higher in the test group (−26.8% ± 8.1%) than in the placebo group (−6.4% ± 5.8%). Bolke, L., Schlippe, G., Gerß, J. and Voss, W., 2019. A collagen supplement improves skin hydration, elasticity, roughness, and density: Results of a randomized, placebo-controlled, blind study. Nutrients, 11(10), p.2494.
Snow lotus reduce skin cell death Human keratinocyte cells were cultured and divided into a low radiation UVB (L-UVB) group (30 mJ/cm2 for 1h) and a high radiation UVB (H-UVB) group (60 mJ/cm2 for 1h). In both L-UVB and H-UVB groups, the absorbance of the polysaccharides 10 mg/mL and polysaccharides 40 mg/mL was significantly higher than in the UVB group. Guo, Y., Sun, J., Ye, J., Ma, W., Yan, H. and Wang, G., 2016. Saussurea tridactyla Sch. Bip.-derived polysaccharides and flavones reduce oxidative damage in ultraviolet B-irradiated HaCaT cells via a p38MAPK-independent mechanism. Drug Design, Development and Therapy, 10, p.389.
Raspberry reduce skin cell death Human keratinocyte cells that exposed to 0 or 100 mJ/cm2 UVB radiation were treated with different concentration of raspberry. The results showed that Raspberry could effectively attenuate the cell death caused by the UVB exposure in a dose-dependent manner. Raspberry could reduce 50% of cell death with the concentration of 150 μg/mL (EC50). Wang, P.W., Cheng, Y.C., Hung, Y.C., Lee, C.H., Fang, J.Y., Li, W.T., Wu, Y.R. and Pan, T.L., 2019. Red raspberry extract protects the skin against UVB-induced damage with antioxidative and anti-inflammatory properties. Oxidative Medicine and Cellular Longevity, 2019.
Anti-inflammatory of Red Micro Algae (Astaxanthin) Keratinocytes were treated with 0, 1, 5 or 10 µM astaxanthin for 4 h and then irradiated with 5 mJ/cm2 UVB. The levels of inflammatory cytokines, including IL-1α, IL-6, IL-8 and TNF-α, were significantly decreased following treatment with astaxanthin in a dose-dependent manner. Astaxanthin supplements are expected to inhibit inflammation- mediated skin deterioration, such as wrinkle formation and skin moisture decline, that appears in aged skin. Tominaga, K., Hongo, N., Fujishita, M., Takahashi, Y. and Adachi, Y., 2017. Protective effects of astaxanthin on skin deterioration. Journal of Clinical Biochemistry and Nutrition, pp.17-35.
02 REJUVENATE Bird Nest Peptide, Lemon, Vitamin C , Sakura Flower, Apple stem cells
Bird Nest Peptide Keratinocytes play a crucial role in building strong skin barrier to prevent water loss and damage (eg. UV) Fibroblasts promote extracellular matrix and collagen contributes to wound healing and skin elasticity. The results showed that Bird Nest Extract (EBN) significantly promoted the proliferation of keratinocytes at the concentration more than 0.05% and fibroblasts at the concentration more than 0.1% Terazawa, S. and Shimoda, H., 2020. Keratinocyte Proliferative and Wound Healing Effects of Edible Bird’s Nest Extract on Human Skin. Int. J. Biomed. Sci, 16, pp.43-51.
Effect of Apple Stem Cell on Skin Recovery Overall elasticity Elasticity (%) Ratio of elastic recovery Net elasticity Control Day 0 Day 1 Day 7 Day 0 Day 1 Day 7 Day 0 Day 1 Day 7 Betamethasone 0.514 0.571 0.576 0.4 0.402 0.381 0.239 0.209 0.203 Apple stem cell 0.51 0.546 0.595 0.358 0.346 0.425 0.193 0.193 0.233 0.508 0.572 0.75 0.356 0.386 0.575 0.203 0.216 0.327 The parameter, ratio of elastic recovery to the all deformation was the most critical parameter of elasticity for measuring skin aging. All the parameters, particularly ratio of elastic recovery, was significantly increased in the Apple Stem Cell group compared to other groups. There was no significant difference in changes of all the parameters from day 0 to 7 in the control and betamethasone groups. Khayatan, D., Nilforoushzadeh, M.A., Ahmadi Ashtiani, H.R. and Hashemian, F., 2022. Effect of Apple (Malus domestica) Stem Cells on UVB-Induced Damage Skin with Anti-Inflammatory Properties: An In Vivo Study. Advances in Materials Science and Engineering, 2022.
Sakura flower aka cherry blossom Sakura group Placebo group Spots Redness Spots Redness Before 2.00 ± 0.32 1.31 ± 0.27 2.02 ± 0.23 1.24 ± 0.17 After 8 weeks 1.86 ± 0.32 1.12 ± 0.27 1.98 ± 0.24 1.11 ± 0.12 The number of facial spots and reddish areas decreased significantly in the Sakura group, while these parameters did not change significantly in the placebo group. The results were assessed by a face image analyzer (VISIA Evolution, Canfield Scientific, USA) Matsuyama, A., Kikuchi, M. and Shimoda, H., 2018. Effect on skin condition by 8-week ingestion of standardized cherry blossom flower extract (sakura extract-P). Int J Biomed Sci, 14(1), pp.12-9.
Synergistic Effect Lemon & Vitamin C Citric acid and Vitamin C q Remove dead skin cells can reduce fine lines and wrinkles q Brighten the skin by reducing pigmentation q Improve dark circles of the lower eyelid q Promote collagen synthesis q Boost wound healing q Anti-inflammatory can soothe sunburns Alpha-hydroxy acids q Treat acne q Improve acne-prone skin from within
03 BOOSTER Soy Peptide, Tremella, Turmeric, Blueberry
Antioxidant bioactive Blueberry & Turmeric Blueberry Turmeric High in anthocyanins Bioactive curcumin o Fight free radical to prevent o Provide natural glow to skin o Heal wounds with positive effect on premature aging o Reduce skin inflammation tissues and collagen o Boost collagen o Anti-inflammatory o Promote wound healing o Reduce scarring
Dual Actions Soy peptide & Tremella Soy peptide Tremella Regulate inflammatory Form transparent film Ø Help for fibroblast proliferation and Ø Prevent the loss of water and collagen synthesis collagen in the skin Ø Ease wound skin repair Ø Natural moisturizer & anti-wrinkle agent
Nitric – O For Ultimate Cardiovascular Health BENEFITS OF L-ARGININE Supports cardiovascular health Enhances blood flow to vital organs Combats the negative effects of premature cardiovascular aging. Anti-aging benefits and supports healthy sexual performance Nitric oxide is a molecule that's produced naturally by your body, and it's important for many aspects of your health. Its most important function is vasodilation, meaning it relaxes the inner muscles of the blood vessels, causing them to widen and increase circulation
INGREDIENTS 02 CONTENT BOOSTERS 01 PROTECTORS Pomegranate, Tomato, Orange and Mangosteen Red Beet, Spirulina, Soy Peptide, Pumpkin Seed, Carrageenan Seaweed, and Multigrain
01 PROTECTORS Red Beet, Spirulina, Soy Peptide, Pumpkin Seed, Carrageenan Seaweed, and Multigrain
Red Beet Lowers Blood Pressure During the experiment, one group was given beetroot juice and control group was given water. The peak difference in systolic BP was achieved at 2.5 hours after ingestion of beetroot juice with a drop of 10.4 ± 3.0 mm Hg (P<0.01), whereas the peak differences in diastolic BP were seen at 3 hours after ingestion of beetroot juice, with changes of 8.1 ± 2.1 mmHg (P<0.01). The reduction of blood pressure was contributed by the increase of plasma nitrite concentration, as red beet is rich in nitrates that can be converted to nitric oxide in the body. Coles, L.T. and Clifton, P.M., 2012. Effect of beetroot juice on lowering blood pressure in free-living, disease-free adults: a randomized, placebo-controlled trial. Nutrition journal, 11(1), pp.1-6. Webb, A.J., Patel, N., Loukogeorgakis, S., Okorie, M., Aboud, Z., Misra, S., Rashid, R., Miall, P., Deanfield, J., Benjamin, N. and MacAllister, R., 2008. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension, 51(3), pp.784-790.
Spirulina increases nitric oxide release The results showed that the Spirulina extract induced increase in the ACh-induced response in the aorta with functional endothelium above 60%. This indicates that Spirulina extract seems to act through endothelial-dependent mechanism, which is related to the increased nitric oxide (NO) release. It is observed that Spirulina increased the release of NO in arteries from spontaneously hypertensive rats. Villalpando, D.M., Verdasco-Martín, C.M., Plaza, I., Gómez-Rivas, J., R de Bethencourt, F., Villarroel, M., García, J.L., Otero, C. and Ferrer, M., 2020. Beneficial effects of Spirulina aqueous extract on vasodilator function of arteries from hypertensive rats. International Journal of Vascular Medicine, 2020.
Clinical Studies of Soy Peptide Contains constituents, eg. trypsin inhibitors, phytic acid, saponins, isoflavones etc A meta-analysis ( 38 In studies with normal adults, clinical studies) found that Another study, soy protein significantly postmenopausal women the consumption of soy protein consumed 40 g/d of soy does not appear to have a lowered total cholesterol, protein with either 56 or 90 hypocholesterolemic effect. LDL cholesterol, and mg of isoflavones daily for 6 Therefore, there is no need for triglycerides. Daily soy months. Both showed good concern that soy could cause protein consumption blood lipid profiles (average resulted in a 9.3% change from baseline, 8.2% dangerously low cholesterol decrease in total decrease in non-HDL levels. cholesterol, a 12.9% cholesterol and 4.4% increase Soy protein contains the decrease in LDL in HDL cholesterol). essential amino acids in cholesterol, and a 10.5% sufficient quantities. decrease in triglycerides Erdman Jr, J.W., 2000. Soy protein and cardiovascular disease: a statement for healthcare professionals from the nutrition committee of the AHA. Circulation, 102(20), pp.2555-2559.
Pumpkin Seed effect on serum lipid concentrations Parameters Lab diet Lab diet and P.S AT Diet AT diet and P.S Total cholesterol 1.43 ±0.07 1.88 ±0.04 4.89 ±0.14 2.55 ±0.06 (TC) ( 16 ) ( 15 ) ( 12 ) ( 13 ) ( mmol / L ) 0.60 ±0.03 0.49 ±0.02 3.33 ±0.07 0.70 ±0.03 ( 14 ) ( 10 ) ( 11 ) ( 14 ) LDL — C ( mmol / L ) 0.44 ± 0.02 0.47 ±0.01 0.43 ±0.01 0.89±0.03 ( 13 ) ( 14 ) ( 12 ) ( 15 ) HDL — C ( mmol / L ) Both of TC and LDL-C concentrations were significantly decreased in atherogenic rats treated with pumpkin seeds, as TC concentrations decreased by 48% from 4.89 mmol / L to 2.55 mmol /L, whereas LDL-C concentrations decreased by 79% from 3.33 mmol / L to 0.70 mmol / L. The serum HDL-C concentrations of atherogenic rats was significantly increased when supplemented with pumpkin seeds. Thus, pumpkin seeds supplementation has a protective effect against atherogenic rats. Abuelgassim, A.O. and Al-Showayman, S.I., 2012. The effect of pumpkin (Cucurbita Pepo L) seeds and L-arginine supplementation on serum lipid concentrations in atherogenic rats. African Journal of Traditional, Complementary and Alternative Medicines, 9(1), pp.131-137.
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