RESUMEN INVESTIGADORES-2

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR recurrence disease (p = 0.006) and shorter distance recurrence-free survival (p = 0.05) was associated with lack of p16. CONCLUSIONS: In our series, EBV infection rates are particularly high for nonendemic NPC, although without a statistically significant difference in overall survival, LMP1 and p16 expression was correlated with poorer clin- ical prognosis. Probably, LMP1 and p16 detection identify a worse clinical prognosis in NPC patient subgroup. CITA: Arch Med Res. 2014 Apr; 45(3):229-36 DOI: 10.1016/j.arcmed.2014.02.002 PMID: 24679069 TÍTULO: Sublingual immunotherapy: World Allergy Organization position pa- per 2013 update AUTORES: Canonica GW, Cox L, Pawankar R, Baena-Cagnani CE, Blaiss M, Bonini S, Bousquet J, Calderón M, Compalati E, Durham SR, van Wijk RG, Larenas-Linnemann D, Nelson H, Passalacqua G, Pfaar O, Rosário N, Ryan D, Rosenwasser L, Schmid-Grendelmeier P, Senna G, Valovirta E, Van Bever H, Vichyanond P, Wahn U, Yusuf O. ABSTRACT: We have prepared this document, \"Sublingual Immunothera- py: World Allergy Organization Position Paper 2013 Update\", according to the evidence-based criteria, revising and updating chapters of the originally published paper, \"Sublingual Immunotherapy: World Allergy Organization Position Paper 2009\", available at http://www.waojournal.org. Namely, these comprise: \"Mechanisms of sublingual immunotherapy;\" \"Clinical efficacy of sublingual immunotherapy\" -reporting all the data of all controlled trials pub- lished after 2009; \"Safety of sublingual immunotherapy\" - with the recently published Grading System for adverse reactions; \"Impact of sublingual im- munotherapy on the natural history of respiratory allergy\" - with the relevant evidences published since 2009;\"Efficacy of SLIT in children\" - with detailed analysis of all the studies; \"Definition of SLIT patient selection\" - reporting the criteria for eligibility to sublingual immunotherapy; \"The future of immu- notherapy in the community care setting\"; \"Methodology of clinical trials ac- cording to the current scientific and regulatory standards\"; and \"Guideline development: from evidence-based medicine to patients' views\" - including the evolution of the methods to make clinical recommendations. Addition- ally, we have added new chapters to cover a few emerging crucial topics: \"Practical aspects of schedules and dosages and counseling for adherence\" - which is crucial in clinical practice for all treatments; \"Perspectives and new approaches\" - including recombinant allergens, adjuvants, modified aller- gens, and the concept of validity of the single products. Furthermore, \"Rais- ing public awareness about sublingual immunotherapy\", as a need for our patients, and strategies to increase awareness of allergen immunotherapy (AIT) among patients, the medical community, all healthcare stakeholders, and public opinion, are also reported in detail. CITA: World Allergy Organ J. 2014 Mar 28; 7(1):6 DOI: 10.1186/1939-4551-7-6 PMID: 24704280 TÍTULO: Soft tissue sarcomas of the head and neck. Clinical and pathologi- cal evaluation of 108 cases in Mexico AUTORES: Salcedo-Hernández RA, Lino-Silva LS, Mosqueda-Taylor A, Luna-Ortiz K. 151

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR BACKGROUND: Sarcomas constitute 1% of all malignancies, but 10% oc- cur in the head and neck (HN), and they are poorly understood. We present a large series of Soft Tissue HN sarcomas in Mexican patients with survival analysis. STUDY DESIGN: This is a retrospective study of cases in a cancer hospital. METHODS: Review of files and pathology material. Literature review. RESULTS: We analyzed 108 patients (55 men / 53 women). The age at presentation was 37 years. The original diagnosis changed in nine cases (8.3%). The most common subtype was rhabdomyosarcoma. Ninety percent of tumours were deep, 91%were high grade, 44% had metastasis, 63% mea- sured >5 cm, overall 5-year survival (5 y-OS) was 48%, and histological high grade was associated with poor survival (p = 0.026). CONCLUSION: Sarcomas of the HN are rare. The most affected sites were paranasal sinuses. The majority of tumours were deep, > 5 cm and high grade, 50% had metastasis, the 5 y-OS was 48% and the only independent factor associated with 5 y-OS was histologic grade. CITA: J Craniomaxillofac Surg. 2014 Dec; 42(8):1566-71 DOI: 10.1016/j.jcms.2014.01.033 PMID: 24732477 TÍTULO: Virtual reality for improving body image disorders and weight loss after gastric band surgery: a case series AUTORES: Cárdenas-López G, Torres-Villalobos G, Martinez P, Carreño V, Duran X, Dakanalis A, Gaggioli A, Riva G. SUMMARY: Laparoscopic Adjustable Gastric Banding (LAGB) is a common surgery method used to help obese patients to lose weight. However, even if LAGB is able to produce a durable and relevant weight loss, it is less effec- tive in improving body image: as demonstrated by a recent study, obese pa- tients with a body image disorder in the pre-operative stage continue to show this even 13 months after the operation. In this presentation we will discuss the possible role of virtual reality (VR) in addressing this problem within an integrated cognitive behavioral approach. To test this approach, a case se- ries of three LAGB patient who experienced body dissatisfaction even after a & gt; 30/40% excess body weight loss, is presented and discussed. At the end of the 6-week protocol the patients experienced a 15%-20%further reduction of their weight. This reduction was also matched by a general im- provement of the psychological state. Both the weight loss and the level of well-being were further improved after a three-month follow-up. CITA: Stud Health Technol Inform. 2014; 196:43-7 DOI: 10.3233/978-1-61499-375-9-43 PMID: 24756021 TÍTULO: New strategies for treating hepatic encephalopathy AUTORES: Gómez-Gutiérrez C, Manzano-Robleda MC, Uribe M, Mén- dez-Sánchez N. SUMMARY: Letter to the editor 152

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR CITA: Ann Hepatol. 2014 May-Jun; 13(3):409-11 DOI: 10.1016/S1665-2681(19)30875-0 PMID: 24781917 TÍTULO: Patient-reported outcomes and quality-of-life questionnaires in the assessment of rhinoconjunctivitis in childhood AUTORES: Larenas-Linnemann D, Pfaar O. PURPOSE OF REVIEW: Rhino conjunctivitis, and especially allergic rhino conjunctivitis (ARC) are increasing in prevalence, progressively affecting the wellbeing of more and more adults and children. Clinical trials using allergen immunotherapy (AIT), the sole causal treatment of allergies, are being con- ducted, but discussions on optimal patient-related outcomes (PROs) are still ongoing. RECENT FINDINGS: Almost all publications discussing PROs relate to adults. The authors comment on the importance of broader PROs when as- sessing the results of AIT trials, as focusing on only nasal symptom improve- ment and medication reduction does not capture the full benefit of AIT. Such intervention also improves comorbid allergic diseases and general wellbe- ing. In studies on rhino conjunctivitis in children, using medical treatment or immunotherapy published between November 2012 - February 2014 nasal symptom (and medication) scores were primary outcomes in 18 of 20 trials. Only two trials applied quality-of-life questionnaires. SUMMARY: Clinical trials conducted in children with ARC should be inter- preted with caution, as most currently used PROs give a restricted view, by not considering disease manifestations beyond nasal/ocular symptoms. To correctly estimate the full benefit of AIT in pediatric patients with ARC, broader PROs should be investigated, including disease control and quality of health. CITA: Curr Opin Allergy Clin Immunol. 2014 Jun; 14(3):192-9 DOI: 10.1097/ACI.0000000000000062 PMID: 24790454 TÍTULO: Acute-on-chronic liver failure: a review AUTORES: Zamora Nava LE, Aguirre Valadez J, Chávez-Tapia NC, Torre A. SUMMARY: There is no universally accepted definition of acute-on-chronic liver failure; however, it is recognized as an entity characterized by decom- pensation from an underlying chronic liver disease associated with organ failure that conveys high short-term mortality, with alcoholism and infection being the most frequent precipitating events. The pathophysiology involves inflammatory processes associated with a trigger factor in susceptible indi- viduals (related to altered immunity in the cirrhotic population). This review addresses the different definitions developed by leading research groups, epidemiological and pathophysiological aspects, and the latest treatments for this entity. CITA: Ther Clin Risk Manag. 2014 Apr 23; 10:295-303 DOI: 10.2147/TCRM.S59723 153

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 24796527 TÍTULO: Heart calcification (idiopathic cardiac osseous metaplasia): a case PMID: 24836779 report AUTORES: Avila-Vanzzini N, Trevethan-Cravioto S, Lopez-Mora E, Herre- PMID: 24838330 ra-Bello H, Soto-Abraham V, Martínez-Rios MA. SUMMARY: Case report CITA: Arch Cardiol Mex. 2014 Apr-Jun; 84(2):140-2 DOI: 10.1016/j.acmx.2013.06.001 TÍTULO: [Medical significance of endothelial glycocalyx. Part 2: Its role in vascular diseases and in diabetic complications] AUTORES: Frati Munari AC. SUMMARY: Endothelial glycocalyx is a layer composed by glycosaminogly- cans, proteoglycansand glycoproteins attached to the vascular endothelial luminal surface. Shredding of glycocalyx appears as an essential initial step in the pathophysiology of atherosclerosis and microangiopathic complica- tions of diabetes mellitus, as well as in chronic venous disease. Atheroscle- rosis risk factors, as hypercholesterolemia (LDL), hyperglycemia, inflamma- tion, salt excess and altered shear stress can damage glycocalyx. This lead to endothelial dysfunction and allows LDL and leukocytes to filtrate to the sub endothelial space initiating atheroma plaque formation. Degradation of glycocalyx in diabetes mellitus is mainly due to oxidative stress and enables protein filtration (albuminuria) and endothelial disorder of microangiopathy. Chronic venous hypertension brings to altered shears stress which results in shredded glycocalyx, this allows leukocytes to migrate into venous wall and initiate inflammation leading to morphologic and functional venous chang- es of the chronic venous disease. Treatment with glycosaminoglycans (su- lodexide) prevents or recovers the damaged glycocalyx and several of its consequences. This drug improves chronic venous disease and promotes healing of chronic venous ulcers. It has also been useful in peripheral arteri- al obstructive disease and in diabetic nephropathy with albuminuria. CITA: Arch Cardiol Mex. 2014 Apr-Jun; 84(2):110-6 DOI: 10.1016/j.acmx.2013.10.006 TÍTULO: Endometrial stromal sarcomas: immunoprofile with emphasis on HMB45 reactivity AUTORES: Albores-Saavedra J, Dorantes-Heredia R, Chablé-Montero F, Chanona-Vilchis J, Pérez-Montiel D, Lino-Silva LS, González-Romo MA, Ramírez-Jaramillo JM, Henson DE. OBJECTIVES: We describe the morphologic and immunohistochemical fea- tures of 17endometrial stromal neoplasms, 16 sarcomas, and one stromal nodule. METHODS: We reviewed 35 cases interpreted as endometrial stromal neo- plasms, but17 high-grade endometrial stromal sarcomas (ESS) and one case of mixed endometrial sarcoma and leiomyosarcoma were excluded from the study. Data from the Surveillance Epidemiology and End Results program on low- and high-grade ESS for 1973 through 2003 were obtained. 154

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR RESULTS: One uterine primary ESS had collections of clear cells (20%), while a metastatic ESS contained predominantly clear cells (90%). CD10 (88.2%) and smooth muscle actin (70.5%) were the most common positive immunohistochemical markers. The latter marker was located in the cyto- plasm in 47% of the ESS and in thenucleus in 23.5%, a previously unreport- ed feature. HMB45 was detected in 23.5% ofthe ESS, which contrasts with the 2% reported by other authors. CONCLUSIONS: The presence of clear cells and HMB45 reactivity does not justify the term perivascular epithelioid cell tumors for these neoplasms. Two of 17patients with ESS died of metastatic disease. However, among 274 cases of ESS (all stages included) collected by the Surveillance Epide- miology and End Results Program of the National Cancer Institute during a 30-year period, the 10-yearsurvival rate was 94%. CITA: Am J Clin Pathol. 2014 Jun; 141(6):850-5 DOI: 10.1309/AJCPS88CMJRXZBWA PMID: 24927613 TÍTULO: Hemodynamic effect of carvedilol vs. propranolol in cirrhotic pa- tients: Systematic review and meta-analysis AUTORES: Aguilar-Olivos N, Motola-Kuba M, Candia R, Arrese M, Méndez- -Sánchez N, Uribe M, Chávez-Tapia NC. BACKGROUND: Carvedilol appears to be more effective than propranolol in the treatment of portal hypertension in cirrhotic patients. AIM: To compare the effects of carvedilol vs. propranolol on systemic and splanchnic haemodynamics and to evaluate the adverse events associated with these treatments. MATERIAL AND METHODS: We performed a systematic review following the Cochrane and PRISMA recommendations. Randomised controlled trials comparing carvedilol versus propranolol, in the treatment of portal hyperten- sion in cirrhotic patients with oesophageal varices, with or without bleeding history were included. The primary outcome measure was the haemodynam- ic response to treatment. RESULTS: Four randomised trials and 153 patients were included; 79 pa- tients received carvedilol (6.25-50 mg/d) and 74 patients received propran- olol (10-320mg/d). The hepatic vein pressure gradient (HVPG) decreased more with carvedilol than with propranolol (MD -2.21; 95% CI: -2.83 to -1.60, I (2) = 0%, P < 0.00001). Carvedilol was superior to propranolol for reducing HVPG by ≥ 20% from the baseline value or to ≤ 12 mmHg (OR: 2.93; 95% CI: 1.50 to 5.74, I (2) = 22%, P =0.002). Overall adverse events did not differ between. In conclusion, there is limited evidence suggesting that carvedilol is more effective than propranolol for improving the haemodynamic re- sponse in cirrhotic patients with portal hypertension. Long-term randomized controlled trials are needed to confirm this information. CITA: Ann Hepatol. 2014 Jul-Aug;13(4):420-8 DOI: 10.1016/S1665-2681(19)30849-X PMID: 24941973 TÍTULO: [ARIA Mexico 2014. Adaptation of the Clinical Practice Guide ARIA 2010 for Mexico. Methodology ADAPTE] 155

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR AUTORES: Larenas-Linnemann D, Mayorga-Butrón JL, Sánchez-González A, Ramírez-García A, Medina-Ávalos M, Figueroa-Morales MA, Mon- taño-Velázquez BB, Montes-Narváez G, Romero-Tapia S, Stone-Aguilar H, Xochihua-Díaz L, Salas-Hernández J, Hernán-Ruiz H, Betancourt-Suárez MA, Cano-Salas MC, Curiel-Aceves L, Dibildox-Martínez J, Fernández-Ve- ga M, García-Bolaños C, Iduñate-Palacios F, Jiménez-Chobillon MA, López-Lizárraga DN, Matta-Campos JJ, Olvera-Salinas J, Rivera-Gómez MA, Virgen-Ortega C, Sienra-Monge JJ, Del Río-Navarro B, Arias-Cruz A, Sacre-Hazouri A, Aguilar-Aranda A, Vásquez Del Mercado-Cordero R, Barni- ca RH, Velasco-Hidalgo L, Solís-Galicia C BACKGROUND: The global prevalence of allergic rhinitis is high. Interna- tional Study of Asthma and Allergies in Childhood (ISAAC) Phase III reports a total estimated prevalence of 4.6% in Mexico. There is evidence based on allergic rhinitis Clinical Practice Guidelines (CPG), but its promotion, accep- tance and application is not optimal or adequate in Mexico. OBJECTIVE: To generate a guideline for the treatment of allergic rhinitis and its impact on asthma by adaptating the 2010 ARIA Guideline to Mexican reality, through a transculturation process applying the ADAPTE methodology. PATIENTS AND METHOD: Using the ADAPTE Methodology, the original 2010 ARIA CPG recommendations were evaluated by the guideline devel- opment group (GDG) into which multiple medical specialities managing pa- tients with allergic rhinitis were incoorporated. The GDG valorated the quality of 2010 ARIA, checked and translated key clinical questions. Moreover, the GDG adjusted recommendations, patient preferences and included com- ments in the context of the Mexican reality (safety, costs and cultural issues). To accomplish this, we ran Delphi panels with as many rounds as necessary to reach agreement. One extra question, not included in the original 2010 ARIA, on the use of Nasal Lavages for AR was created sustained by a sys- tematic literature review. RESULTS: A total of 45 questions from the original 2010 ARIA were included and divided into six groups covering prevention, medical treatment, immuno- therapy, and alternative medicine to treat patients with allergic rhinitis with or without asthma. Most of the questions reached agreement in one or two rounds; one question required three rounds. CONCLUSIONS: An easy-to-use, adaptated, up-to-date and applicable al- lergic rhinitis guideline for Mexico is now available. CITA: Rev Alerg Mex. 2014; 61 Suppl 1:S3-S116 PMID 24976949 TÍTULO: Allergen sensitization linked to climate and age, not to intermit- tent-persistent rhinitis in a cross-sectional cohort study in the (sub)tropics AUTORES: Larenas-Linnemann D, Michels A, Dinger H, Shah-Hosseini K, Mösges R, et al. BACKGROUND: Allergen exposure leads to allergen sensitization in sus- ceptible individuals, and this might influence allergic rhinitis (AR) phenotype expression. We investigated whether sensitization patterns vary in a country with sub tropicaland tropical regions and if sensitization patterns relate to AR phenotypes orage. METHODS: In a national, cross-sectional study AR patients (2-70 y) seen by allergists underwent blinded skin prick testing with a panel of 18 allergens and completed a validated questionnaire on AR phenotypes. 156

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 24980234 RESULTS: 628 patients were recruited. The major sensitizing allergen was house dust mite (HDM) (56%), followed by Bermuda grass (26%), ash (24%), oak (23%) and mesquite (21%) pollen, cat (22%) and cockroach (21%). Pa- tients living in the tropical region were almost exclusively sensitized to HDM (87%). In the central agricultural zones sensitization is primarily to grass and tree pollen. Nationwide, most study subjects had perennial (82.2%), intermit- tent (56.5%) and moderate-severe (84.7%) AR. Sensitization was not related to the intermittent-persistent AR classification or to AR severity; seasonal AR was associated with tree (p < 0.05) and grass pollen sensitization (p < 0.01). HDM sensitization was more frequent in children (0-11 y) and adolescents (12-17 y) (subtropical region: p < 0.0005; tropical region p < 0.05), but pol- len sensitization becomes more important in the adult patients visiting al- lergists(Adults vs children + adolescents for tree pollen: p < 0.0001, weeds: p < 0.0005). CONCLUSIONS: In a country with (sub) tropical climate zones SPT sensi- tization patterns varied according to climatological zones; they were differ- ent from those found in Europe, HDM sensitization far outweighing pollen allergies and Bermuda grass and Ash pollen being the main grass and tree allergens, respectively. Pollen sensitization was related to SAR, but no re- lation between sensitization and intermittent-persistent AR or AR severity could be detected. Sensitization patterns vary with age (child HDM, adult pollen). Clinical implications of our findings are dual: only a few allergens -some region specific- cover the majority of sensitizations in (sub) tropi- cal climate zones. This is of major importance for allergen manufacturers and immunotherapy planning. Secondly, patient selection in clinical trials should be based on the intermittent-persistent and severity classifications, rather than on the seasonal-perennial AR subtypes, especially when con- ducted in (sub) tropical countries. CITA: Clin Transl Allergy. 2014 Jun 4; 4:20 DOI: 10.1186/2045-7022-4-20 TÍTULO: In the (sub)tropics allergic rhinitis and its impact on asthma classifica- tion of allergic rhinitis is more useful than perennial-seasonal classification AUTORES: Larenas-Linnemann D, Michels A, Dinger H, Arias-Cruz A, Am- briz Moreno M, Bedolla Barajas M, et al. BACKGROUND: Two different allergic rhinitis (AR) symptom phenotype classifications exist. Treatment recommendations are based on intermit- tent-persistent (INT-PER) cataloging, but clinical trials still use the former seasonal AR-perennial AR (SAR-PAR) classification. This study was de- signed to describe how INT-PER, mild-moderate/severe and SAR-PAR of patients seen by allergists are distributed over the different climate zones in a (sub) tropical country and how these phenotypes relate to allergen sensi- tization patterns. METHODS: Six climate zones throughout Mexico were determined, based on National Geographic Institute (Instituto Nacional de Estadística y Geografía) data. Subsequent AR patients (2-68 years old) underwent a blinded, standardized skin-prick test and filled out a validated questionnaire phenotyping AR. RESULTS: Five hundred twenty-nine subjects participated in this study. In the tropical zone with 87% house-dust mite sensitization, INT (80.9%; p < 0.001) 157

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR and PAR (91%; p = 0.04) were more frequent than in the subtropics. In the central high-pollen areas, there was less moderate/severe AR (65.5%; p < 0.005). Frequency of comorbid asthma showed a clear north-south gradient, from 25% in the dry north to 59% in the tropics (p < 0.005). No differences exist in AR cataloging among patients with different sensitization patterns, with two minor exceptions (more PER in tree sensitized and more PAR in mold positives; p <0.05). seems of limited value and bears poor relation with the INT-PER classifi- cation. INT is more frequent in the tropical zone. Because PER has been shown to relate to AR severity, clinical trials should select patients based on INT-PER combined with the severity cataloging because these make for a better treatment guide than SAR-PAR. CITA: Am J Rhinol Allergy. 2014 May-Jun; 28(3):232-8 DOI: 10.2500/ajra.2014.28.4035 PMID: 24991202 TÍTULO: Global diffusion tensor imaging derived metrics differentiate glio- blastoma multiforme vs. normal brains by using discriminant analysis: intro- duction of a novel whole-brain approach AUTORES: Roldan-Valadez E, Rios C, Cortez-Conradis D, Favila R, More- no-Jimenez S. BACKGROUND: Histological behavior of glioblastoma multiforme sug- gests it would benefit more from a global rather than regional evaluation. A global(whole-brain) calculation of diffusion tensor imaging (DTI) derived tensor metrics offers a valid method to detect the integrity of white matter structures without missing infiltrated brain areas not seen in conventional sequences. In this study we calculated a predictive model of brain infiltration in patients with glioblastoma using global tensor metrics. METHODS: Retrospective, case and control study; 11 global DTI-derived tensor metrics were calculated in 27 patients with glioblastoma multiforme and 34controls: mean diffusivity, fractional anisotropy, pure isotropic diffu- sion, pure anisotropic diffusion, the total magnitude of the diffusion tensor, linear tensor, planar tensor, spherical tensor, relative anisotropy, axial dif- fusivity and radial diffusivity. The multivariate discriminant analysis of these variables (including age) with a diagnostic test evaluation was performed. RESULTS: The simultaneous analysis of 732 measures from 12 continuous variables in 61 subjects revealed one discriminant model that significantly differentiated normal brains and brains with glioblastoma: Wilks' λ = 0.324, χ(2) (3) = 38.907, p < .001. The overall predictive accuracy was 92.7%. CONCLUSIONS: We present a phase II study introducing a novel global approach using DTI-derived biomarkers of brain impairment. The final pre- dictive model selected only three metrics: axial diffusivity, spherical tensor and linear tensor. These metrics might be clinically applied for diagnosis, fol- low-up, and the study of other neurological diseases. CITA: Radiol Oncol. 2014 Apr 25;48(2):127-36 DOI: 10.2478/raon-2014-0004 158

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 24998696 TÍTULO: Latin American Association for the Study of the Liver (LAASL) clini- cal practice guidelines: management of hepatocellular carcinoma PMID: 25152995 PMID: 25160071 AUTORES: Méndez-Sánchez N, Ridruejo E, Alves de Mattos A, Chávez- -Tapia NC, Zapata R, Paraná R, Mastai R, Strauss E, Guevara-Casallas LG, Daruich J, Gadano A, Parise ER, Uribe M, Aguilar-Olivos NE, Dagher L, Ferraz-Neto BH, Valdés-Sánchez M, Sánchez-Avila JF. SUMMARY: Hepatocellular carcinoma (HCC) is the fifth most common can- cer in the world and the third most common cause of cancer death, and accounts for 5.6% of all cancers. Nearly 82% of the approximately 550,000 liver cancer deaths each year occur in Asia. In some regions, cancer-related death from HCC is second only to lung cancer. The incidence and mortality of HCC are increasing in America countries as a result of an ageing cohort infected with chronic hepatitis C, and are expected to continue to rise as a consequence of the obesity epidemic. Clinical care and survival for patients with HCC has advanced considerably during the last two decades, thanks to improvements in patient stratification, an enhanced understanding of the pathophysiology of the disease, and because of developments in diagnostic procedures and the introduction of novel therapies and strategies in preven- tion. Nevertheless, HCC remains the third most common cause of cancer-re- lated deaths worldwide. These LAASL recommendations on treatment of hepatocellular carcinoma are intended to assist physicians and other health care providers, as well as patients and other interested individuals, in the clinical decision-making process by describing the optimal management of patients with liver cancer. CITA: Ann Hepatol. 2014 May; 13 Suppl 1:S4-40 DOI: 10.1016/S1665-2681(19)30919-6 TÍTULO: The good, the bad and the ugly of the new treatments for hepatitis C virus. AUTORES: Silva-Vidal KV, Méndez-Sánchez N. SUMMARY: Letter to the editor CITA: Ann Hepatol. 2014 Sep-Oct; 13(5):574-5 DOI: 10.1016/S1665-2681(19)31262-1 TÍTULO: Progress in the analysis of multiple activity profile of screening data using computational approaches AUTORES: Kuyoc-Carrillo VF, Medina-Franco JL. SUMMARY: The increasing awareness that drugs may have the clinical ef- fect through the interaction with multiple targets is encouraging the screen- ing of investigational compounds across multiple biological endpoints. As the number and complexity of chemogenomics data sets increase, more computational approaches are being developed for the efficient analysis of structure-multiple activity relationships. In silico methods cover a wide range of applications including visual, qualitative, and quantitative approaches to describe in detail multi pleligand-protein relationships, find associations between targets and, whenever possible, to predict the bioactivity profile of small molecules. Here, we present a commentary of representative compu- 159

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR tational methods and their applications to characterize structure-multiple ac- tivity relationships and conduct the rational design of poly pharmacology for the advancement of drug discovery. CITA: Drug Dev Res. 2014 Aug; 75(5):313-23 DOI: 10.1002/ddr.21209 PMID: 25167345 TÍTULO: [Thromboprophylaxis as a quality assessment policy and hospital security] AUTORES: Carrillo-Esper R. SUMMARY: Editorial CITA: Cir Cir. 2014 Jul-Aug; 82(4):363-5 PMID: 25167348 TÍTULO: [Interscalene block for total shoulder arthroplasty: comparative PMID: 25175810 study (ultrasound vs. neurostimulation)] AUTORES: Mejía-Terrazas GE, Ruiz-Suárez M, Gaspar-Carrillo SP, Vale- ro-González F, Unzueta-Navarro D, Encalada-Díaz I. BACKGROUND: Modern anesthesiology has integrated the use of ultraso- nography as a tool that has displaced neurostimulation as a technique for locating peripheral nerves. The aim of this study was to determine which procedure is more effective for guiding interscalene block for total shoulder arthroplasty. METHODS: We carried out a comparative, prospective non-randomized study comprised of the group guided by neurostimulation interscalene block and the group guided by ultrasound. All patients in both groups were sched- uled for total shoulder arthroplasty. Latency, degree of sensory and motor block, success rate, postoperative pain intensity at 6, 12, and 24 h, patient satisfaction and complications were measured. RESULTS: We included 110 patients, 55 per group. Patients were placed in beach chair position and the deltopectoral approach was used. There were no differences in demographic characteristics. Results for neurostimulation vs. ultrasound group: latency 19.11 ± 2.27 vs. 17.24 ± 1.42 min, p= 0.23. Block sensitivity in both groups was grade 0 motor block grade 0 in 76.4% and grade 1 in 23.6% vs. grade 0 to 100%. There was 100% success rate for both groups. Postoperative pain at 6 h was 0.13 ± 0.54 vs. 0.11 ± 0.13 p= 0.90, at 12 h 1.67 ± 1.15 vs. 1.65 ±0.59 p= 0.89 and at 24 h 3.15 ± 1.66 vs. 2.99 ± 1.15 p= 0.78. Satisfaction 54.5% very satisfied and 45.5% satisfied 96.36% vs 3.6% very satisfied and satisfied. Complications 18.18% vs. 3.6% p= 0.023. CONCLUSION: Ultrasound-guided interscalene nerve block is the technique of choice in elective total shoulder arthroplasty. CITA: Cir Cir. Jul-Aug 2014;82(4):381-8 TÍTULO: Association of urothelial carcinoma of the renal pelvis with papillary and medullary thyroid carcinomas. A new sporadic neoplastic syndrome? 160

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 25185535 AUTORES: Albores-Saavedra J, Dorantes-Heredia R, Chablé-Montero F, PMID: 25228947 Córdova-Ramón JC, Henson DE. SUMMARY: We describe 2 adult women (72 and 54 years), 1 with a low- grade noninvasive papillary urothelial carcinoma of the renal pelvis, who 14 years later developed a papillary carcinoma in 1 thyroid lobe and a medul- lary carcinoma in the contralateral lobe. Both neoplasms were similar in size and appeared symmetrical. Despite its small size, the medullary carcinoma metastasized in multiple cervical lymph nodes. The second patient had a high-grade invasive papillary urothelial carcinoma of the renal pelvis that infiltrated the renal parenchyma and metastasized in one of the lungs. Five months later, a papillary carcinoma was discovered in the thyroid gland. The 2 papillary thyroid carcinomas were of the follicular variant. Adjacent to 1 papillary carcinoma, there was a dominant nodule of a colloid and adeno- matous goiter. The medullary carcinoma contained stromal amyloid and was immune reactive for calcitonin and carcinoembryonic antigen. There was no C-cell hyperplasia (medullary carcinoma in situ). The 2patients are alive, 1 is living with pulmonary metastasis from the high-grade urothelial carcinoma. Twelve cases of this neoplastic association were registered in the Survey, Epidemiology, and End Results Program from 1980 to 2009. We believe that the combination of these unusual neoplasms in the same patient may repre- sent a new sporadic neoplastic syndrome. CITA: Ann Diagn Pathol. 2014 Oct; 18(5):286-90 DOI: 10.1016/j.anndiagpath.2014.08.003 TÍTULO: Latin American Association for the Study of the Liver recommenda- tions on treatment of hepatitis C AUTORES: Méndez-Sánchez N, Paraná R, Cheinquer H, Alves de Mattos A, Gadano A, Silva M, Pessôa MG, Gomes-Ferraz ML, Soza A, Mendes-Cor- rea MC, Chávez-Tapia NC, Dagher L, Padilla M, Hernandez N, Sánchez-A- vila JF, Contreras F, Moraes-Coelho HS, Parise ER, Bessone F, Uribe M SUMMARY: Review article CITA: Ann Hepatol. 2014 Aug; 13 Suppl 2:s4-66 DOI: 10.1016/S1665-2681(19)30920-2 TÍTULO: Cyanoacrylate spray as treatment in difficult-to-manage gastroin- testinal bleeding AUTORES: Toapanta-Yanchapaxi L, Chavez-Tapia N, Téllez-Ávila F. SUMMARY: Gastrointestinal bleeding can be a life-treating event that is managed with standard endoscopic therapy in the majority of cases. Howev- er, up to 5%-10% of patients may have persistent bleeding that does not re- spond to conventional measures. Several endoscopic treatment techniques have been proposed as strategies to control such cases, such as epineph- rine injection, hemo clips or argon plasma coagulation, but there are certain clinical scenarios where it is difficult to achieve hemostasis even though ade- quate use of the available resources is made. Reasons for these failures can be associated with the lesion features, such as extent or location. The use of long-standing techniques in non-traditional scenarios, such as with cyanoac- rylate for gastric varices sclerosis, has been reported with favorable results. 161

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 25259428 Although new products such as TC-325 or Ankaferd Blood Stopper hemo PMID: 25290418 sprays may be useful, their formulations are not available worldwide. Here we present two clinical cases with very different scenarios of gastrointestinal bleeding, where the use of cyanoacrylate in spray had favorable results in uncommon indications. Cyanoacrylate used as a spray is a technique that can be used as an alternative method in emergent settings. CITA: World J Gastrointest Endosc. 2014 Sep 16; 6(9):448-52 DOI: 10.4253/wjge.v6.i9.448 TÍTULO: [Laparoscopic vs opened appendicovesicostomy in pediatric pa- tients] AUTORES: Landa-Juárez S, Montes de Oca-Muñoz LE, Castillo-Fernández AM, de la Cruz-Yañez H, García-Hernández C, Andraca-Dumit R. BACKGROUND: Appendicovesicostomy is commonly employed to facilitate drainage of urine through the catheter. Due to the tendency to less invasive procedures for the treatment of patients with neurogenic bladder, laparos- copy has been used as an alternative to open surgery, with the immediate advantages of postoperative recovery, shorter postoperative ileus, better cosmetic results, lower postoperative pain and early reintegration into ev- eryday life. PURPOSE: Compare the results of laparoscopic procedure with open ap- pendicovesicostomy. METHODS: We conducted an observational, analytical, longitudinal, ambi- spective cohort study, which included patients from 6-16 years of age di- agnosed with neurogenic bladder, operated through laparoscopic and open appendicovesicostomy from January 2009 to June 2013. Information was obtained from clinical records. Six patients were operated laparoscopically and 14 by open approach. RESULTS: Surgical time was longer and statistically significant in the lapa- roscopic group with a median of 330 min (300-360 min) compared to open procedure of 255 min (180-360 min). Seven patients had complications in the open group and only one in the laparoscopic group. The difference in the dose of analgesics and time of use was statistically significant in favor of the laparoscopic group. The degree of urinary continence through the stoma was higher for laparoscopic (100%) compared to the open procedure (64%). CONCLUSIONS: In neurogenic bladder with urodynamic bladder capacity and leak point pressure bladder within acceptable values, laparoscopic ap- pendicovesicostomy was a better alternative. CITA: Cir Cir. 2014 Sep-Oct; 82(5):496-504 TÍTULO: Selection of patients for sublingual versus subcutaneous immuno- therapy AUTORES: Larenas Linnemann DE, Blaiss MS. ABSTRACT: Allergen immunotherapy is the sole treatment for IgE-mediated allergic diseases directed at the underlying mechanism. The two widely ac- cepted administration routes are sublingual (SLIT) and subcutaneous (SCIT). 162

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR We reviewed how patients should best be selected for immunotherapy and how the optimal administration route can be defined. Before deciding SCIT or SLIT, appropriate selection of patients for allergen immunotherapy (AIT) is mandatory. To be eligible for AIT, subjects must have a clear medical history of allergic disease, with exacerbation of symptoms on exposure to one or more allergens and a corresponding positive skin or in vitro test. Then the route of administration should be based on: published evidence of clinical and immunologic efficacy (which varies per allergic disease and per aller- gen); mono- or multi-allergen immunotherapy, for SLIT multi-allergen im- munotherapy was not effective; safety: adverse events with SLIT are more frequent, but less severe; and, costs and patient preferences, closely related to adherence issues. All these are discussed in the article. CITA: Immunotherapy. 2014; 6(7):871-84 DOI: 10.2217/imt.14.55 PMID: 25312324 TÍTULO: [Surgical treatment of type 2 diabetes mellitus] PMID: 25332273 AUTORES: Carrillo-Esper R, Muciño-Bermejo MJ. SUMMARY: Sustained remission of type 2 diabetes mellitus and signifi- cantly improved hyperlipidemia and arterial hypertension, control has been achieves in both lean and obese patient after bariatric surgery procedures or other gastrointestinal surgical procedures. It has been demonstrated that the metabolic effects of bariatric surgery in these patients derives not only in re- ducing weight and caloric intake, but also endocrine changes resulting from surgical manifestation gastrointestinal tract. In this article we review the clin- ical outcomes of such interventions (collectively called \"metabolic surgery\") and the perspectives on the role that these surgeries play in the treatment of patients with type 2diabetes mellitus. CITA: Cir Cir. 2014 Mar-Apr; 82(2):219-30 TÍTULO: Bone metastases as the initial presentation of hepatocellular carci- noma. Two case reports and a literature review. AUTORES: Ruiz-Morales JM, Dorantes-Heredia R, Chable-Montero F, Vazquez-Manjarrez S, Méndez-Sánchez N, Motola-Kuba D. SUMMARY: Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver and is the fifth most common cancer in the world; its inci- dence has been increasing in recent years. Extrahepatic spread is present at the time of diagnosis in only about 5 to 15% of patients. Skeletal metastasis of HCC occurs less frequently compared with other cancers and is consid- ered a rare primary form of presentation. We report two cases of unsuspect- ed HCC presenting with multiple bone lesions as the initial presentation. The first patient was a 76-year-old man with symptoms of fatigue and back pain. The PET-CT revealed the hypercaptant bone lesions and a liver lesion. The pathology report showed that the metastases were positive for the hepatic marker HEPAR-1, indicating that they had originated from the HCC. The sec- ond patient was a 56-year-old man. He presented to the emergency depart- ment for right shoulder pain and weakness of the entire right arm with no his- tory of trauma. During hospitalization, the patient became quadriplegic. MRI revealed osseous blastic lesions in the cervical vertebrae and right shoulder. A CT-guided biopsy was performed in the cervical lesion and showed poor- 163

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 25360344 ly differentiated carcinoma. Immunohistochemistry staining was positive for HEPAR-1. In conclusion, this cases show an unusual presentation of HCC PMID: 25393857 with skeletal metastasis. PMID: 25393868 CITA: Ann Hepatol. 2014 Nov-Dec; 13(6):838-42 DOI: 10.1016/S1665-2681(19)30989-5 TÍTULO: Clinical impact of indirect markers of renal function in elderly pa- tients with hip fracture AUTORES: López-Martínez C, Tovar-Rivera E, Becerra-Laparra IK, Chá- vez-Tapia NC. INTRODUCTION: There are risk factors associated with mortality in patients older than 70 years with hip fracture, including kidney function. However, indirect formulas to calculate glomerular filtration rate are not validated in patients older than 70 years. We analyzed whether the formula hematocrit, urea, and gender (HUGE) can be used as a prognostic factor. MATERIAL AND METHODS: A retrospective cohort study of 88 patients older than 70years with a diagnosis of hip fracture. At admission, clinical and biochemical parameters were measured and glomerular filtration rate by Cockcroft-Gault, Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), and HUGE value. Accuracy to assess long-term mortality was analyzed with receiver-operat- ing curve analysis. Cox regression analysis was performed to identify risk factor for mortality. RESULTS: Sample included 88 patients; overall mortality was 13.63%, 17.85%, 28.57%, and 75.85% at 6 months, 1, 2, and 3 years, respectively. There was no significant difference in glomerular filtration rate by different formulas, contrary to HUGE, with higher values in the mortality group (1.83 ± 6.38 vs -2.61± 2.70, P = .0001). Survival was lower in patients with higher HUGE values (22.7 months, 95% confidence interval [CI] 16.1-29.5 vs 32.9 months, 95% CI 30.2-35.7; P ≤ .001). In the Cox regression analysis, a neg- ative HUGE value is associated with lower mortality (hazards ratio = 0.238; 95% CI 0.568-0.099). CONCLUSION: The HUGE formula is an independent risk factor for mortal- ity in elderly patients with hip fracture, but not the glomerular filtration rate determined by Cockcroft-Gault, MDRD, and CKD-EPI. CITA: Geriatr Orthop Surg Rehabil. 2014 Sep; 5(3):131-7 DOI: 10.1177/2151458514542336 TÍTULO: [Space medicine] AUTORES: Carrillo-Esper R. SUMMARY: Review article CITA: Cir Cir. 2014 Nov-Dec; 82(6):591-3 TÍTULO: [Therapeutic options for portal hypertensive biliopathy: case series and literature review] 164

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR AUTORES: Aguilar-Olivos NE, de León-Monterroso JL, Avila-Escobedo L, López-Méndez E. BACKGROUND: Portal hypertensive biliopathy is an underdiagnosed con- dition because only some patients have symptoms. The major clinical man- ifestations include cholestasis and cholangitis. The aim of this study is to present a series of cases evaluated, treated and followed at a tertiary-care public institution. CLINICAL CASE: Four patients with portal hypertensive biliopathy were ex- posed to different therapeutic approaches focused on the management of portal hypertension and biliary decompression. They were followed for ~5 years. Three cases achieved a favorable outcome with symptom remission, but one patient died while attempting dilatation of the bile duct. Finally, we carried out a literature review about actual portal hypertensive biliopathy therapeutics. CONCLUSIONS: There is currently no consensus on the optimal treatment for this condition. The goal is to decompress the biliary tree. Each case should be individually evaluated to choose the best treatment option. CITA: Cir Cir. 2014 Nov-Dec; 82(6):680-5 PMID: 25514308 TÍTULO: Assessment of outcomes of hepatitis C treatment AUTORES: Chavez-Tapia NC, Barrientos-Gutierrez T, Uribe M. SUMMARY: Letter to the editor CITA: JAMA. 2014 Dec 17; 312(23):2570-1 DOI: 10.1001/jama.2014.14900 PMID: 25514910 TÍTULO: Common features of the metabolic syndrome and nonalcoholic fat- ty liver disease AUTORES: Almeda-Valdes P, Aguilar-Olivos N, Uribe M, Méndez-Sán- chez N. SUMMARY: Nonalcoholic fatty liver disease (NAFLD) is an important cause of chronic liver disease; including simple steatosis, steatohepatitis, fibrosis, or cirrhosis. The metabolic syndrome (MS) is the existence of metabolic al- terations that confer an increased risk for developing cardiovascular disease and diabetes. NAFLD and MS frequently coexist and 90% of NAFLD patients have more than one manifestation of the MS. In addition, both entities are re- lated to other comorbid conditions. Scientific advances in the understanding of the association between NAFLD and the MS have identified insulin resis- tance as a key aspect in the pathophysiology of both diseases. Knowledge gained from these advances can be applied clinically in the management and prevention of NAFLD, the MS, and associated metabolic alterations. Cardiovascular disease is the leading cause of death in patients with NA- FLD and the MS, therefore adequate diagnosis and effective treatment are critical. This review analyzes current evidence of the association between NAFLD and the MS. The growing prevalence of both entities is highlighted. Next, the common mechanisms leading to insulin resistance are discussed. Manifestations and diagnosis of the MS and NAFLD are reviewed, pointing 165

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 25535587 out the associated comorbid conditions shared by both diseases. Finally, a PMID: 25705408 brief overview regarding NAFLD treatment is presented. PMID: 25724222 CITA: Rev Recent Clin Trials. 2014; 9(3):148-58 DOI: 10.2174/1574887109666141216103908 TÍTULO: Implementation of intensity modulated radiotherapy for prostate cancer in a private radiotherapy service in Mexico AUTORES: Poitevin-Chacón MA, Reséndiz González G, Alvarado Zermeño A, Flores Castro JM, Flores Balcázar CH, Rosales Pérez S, Pérez Pastenes MA, Rodríguez Laguna A, Vázquez Fernández P, Calvo Fernández A, Bastida Ventura J. SUMMARY: Intensity modulated radiation therapy (IMRT) allows physicians to deliver higher conformal doses to the tumour, while avoiding adjacent structures. As a result the probability of tumour control is higher and toxicity may be reduced. However, implementation of IMRT is highly complex and requires a rigorous quality assurance (QA) program both before and during treatment. The present article describes the process of implementing IMRT for localized prostate cancer in a radiation therapy department. In our expe- rience, IMRT implementation requires careful planning due to the need to simultaneously implement specialized software, multifaceted QA programs, and training of the multidisciplinary team.Establishing standardized proto- cols and ensuring close collaboration between a multidisciplinary team is challenging but essential. CITA: Rep Pract Oncol Radiother. 2014 Dec 12; 20(1):66-71 DOI: 10.1016/j.rpor.2014.06.002 TÍTULO: Treatment of diffuse alveolar hemorrhage secondary to lupus er- ythematosus with recombinant activated factor VII administered with a jet nebulizer AUTORES: Esper RC, Estrada IE, de la Torre León T, Gutiérrez AO, López JA. SUMMARY: Diffuse alveolar hemorrhage (DAH) is a serious pulmonary complication in patients with autoimmune diseases who are undergoing che- motherapy or have had hematopoietic stem cell transplantation. The use of recombinant factor VIIa (rFVIIa) to treat the acute phase of DAH by endo- bronchial bronchoscopy has been shown to have a significant clinical impact on the survival and evolution of these patients. We report a clinical case of a patient with DAH secondary to systemic lupus erythematosus (SLE) who was treated with rFVIIa administered using a jet nebulizer, obtaining an ad- equate hemostatic effect with immediate control of DAH and a significant improvement in gas exchange. CITA: J Intensive Care. 2014 Aug 27; 2(1):47 DOI: 10.1186/s40560-014-0047-2 TÍTULO: [Mexican guidelines on the diagnosis and treatment of urticaria] AUTORES: Larenas-Linnemann D, Medina-Ávalos MA, Ortega-Martell JA, Beirana-Palencia AM, Rojo-Gutiérrez MI, et al. 166

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR BACKGROUND: Urticaria is a disease that a fifth of the population shall suffer once in a lifetime. Recent clinical guidelines have proposed some fun- damental changes in the diagnosis and treatment of urticaria, making the development of a national, multidisciplinary guideline, with wide acceptabil- ity among different professional groups -both specialists and primary health care workers-, necessary in Mexico. MATERIAL AND METHOD: Internationally recognized tools for guideline de- velopment were used. An interdisciplinary group of clinical experts (some of them knowledgeable in methodology of guideline development) determined the objectives and scope of the Evidence Based Clinical Practice Guide- line with SCOPE. It was decided to adapt and transculturize international guidelines on the diagnosis and treatment of urticaria. With AGREE-II three high-quality guidelines (Zuberbier2014, Sánchez-Borges 2012, Powell 2007) were selected to function as basic guidelines (BG). A set of Clinical Ques- tions was formulated that lead to recommendations/suggestions, based on these BG, taking into account the cultural and economic background of Mex- ico, according to GRADE recommendation development. RESULTS: By a formal process of discussion and voting during several working-sessions, experts and first level healthcare physicians determined the wording of the final guideline, taking particularly care of developing a document, adjusted to the reality, values and preferences of the Mexican patients. The use of oral second generation, non-sedating antihistamines as first line treatment is emphasized. CONCLUSION: This document is an Evidence Based Clinical Practice Guideline for the diagnosis and treatment of acute and chronic urticaria, based on three, high quality, international guidelines. It was developed by a multidisciplinary group. Tables and algorithms make the guideline user-friendly for both, first line health care physicians and specialists. CITA: Rev Alerg Mex. 2014; 61 Suppl 2:S118-93 PMID: 25758570 TÍTULO: Current concepts on magnetic resonance imaging (MRI) perfu- sion-diffusion assessment in acute ischaemic stroke: a review & an update for the clinicians AUTORES: Roldan-Valadez E, Lopez-Mejia M. SUMMARY: Recently, several medical societies published joint statements about imaging recommendations for acute stroke and transient ischaemic attack patients. In following with these published guidelines, we considered it appropriate to present a brief, practical and updated review of the most rele- vant concepts on the MRI assessment of acute stroke. Basic principles of the clinical interpretation of diffusion, perfusion, and MRI angiography (as part of a global MRI protocol) are discussed with accompanying images for each sequence. Brief comments on incidence and differential diagnosis are also included, together with limitations of the techniques and levels of evidence. The purpose of this article is to present knowledge that can be applied in day-to-day clinical practice in specialized stroke units or emergency rooms to attend patients with acute ischaemic stroke or transient ischaemic attack according to international standards. CITA: Indian J Med Res. 2014 Dec; 140(6):717-28 167

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR 2015 TÍTULO: Real life study of three years omalizumab in patients with diffi- cult-to-control asthma PMID: 24780091 AUTORES: López Tiro JJ, Contreras EA, del Pozo ME, Gómez Vera J, Lar- enas Linnemann D. PMID: 25015669 BACKGROUND: Even though there are multiple options for the treatment of asthma, there still exists a fair group of patients with difficult-to-control asthma. We describe for the first time the real-world effects of three-year omalizumab treatment on patients with difficult-to-control asthma, seen in a social security hospital in a Latin American country. METHODS: Difficult-to-control asthmatic patients from the out-patient clin- ic of a regional hospital were recruited to receive a three-year omalizumab course. Efficacy parameters were asthma control test (ACT) score; FEV1; daily be- clomethasone maintenance dose; and unplanned visits for asthma exacer- bations (emergency room (ER), hospitalizations, intensive care). RESULTS: 52 patients were recruited, 47 completed the three-year treat- ment (42 female, 15-67 years, mean age 43.5). Comparing efficacy param- eters of the year before omalizumab with the 3rd year of omalizumab: mean ACT improved from 12.4 to20.5, mean FEV1 from 66.3% (standard deviation (SD) 19.1%) to 88.4% (SD 16.2%) of predicted, while mean beclometha- sone dose reduced from 1750 to 766 mcg/day and there was a significant reduction in patients experiencing ER visits (from 95% to19%, p<0.0001), hospitalisation (38% to 2%, p<0.0001) and intensive care (4% to0, NS). Five patients discontinued omalizumab, two because of an adverse event (ana- phylaxis, severe headache, both resolved without sequelae). CONCLUSION: Omalizumab improved most clinical parameters of Mexican patients with difficult-to-control asthma. Especially the rates of ER visits and hospitalisation were significantly reduced, thus reducing costs. Omalizumab was generally well tolerated. CITA: Allergol Immunopathol (Madr). 2015 Mar-Apr; 43(2):120-6 DOI: 10.1016/j.aller.2013.11.008 TÍTULO: Colonic cribriform carcinoma, a morphologic pattern associated with low survival AUTORES: Lino-Silva LS, Salcedo-Hernández RA, Herrera-Gómez A, Padilla-Rosciano A, Ramírez-Jaramillo M, Herrera-Goepfert RE, Mene- ses-García A. SUMMARY: Colorectal carcinoma is one of the most common cancers in the human body. Colorectal carcinoma is a heterogeneous disease with variegated morphological patterns; some have shown themselves to have prognostic value. The World Health Organization classification recognizes many histological variants associated with adverse prognostic factors, one is the cribriform colonic carcinoma (CCC). In this work, we analyzed 18 cases of CCC compared with 228 conventional adenocarcinomas of colon, with the hypotheses that CCC compared with non-CCC have worse prognosis and decreased overall survival. CCC represent 7.3% of all colonic adenocarci- 168

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 25256239 nomas in this series, it presents in a median age of 56.3 years, all cases are PMID: 25533428 in clinical stage III and IV, all invade subserosal adipose tissues or serosa, 90% have >5 positive lymph nodes and 89% have lymphovascular invasion. These known adverse prognostic factors reflect a lower 5-year survival, stage by stage, than conventional intestinal-type adenocarcinoma (56.8% vs 83.3%, P =.035). Cribriform carcinoma is a morphologic pattern that is under recognized; in this work, we demonstrate its association with low survival, extensively lymphovascular invasion, and extensive lymph node metastasis, strong indicators of aggressive disease. Their proper recognition is manda- tory to increase the number of cases and series to support our findings and include it in the current classifications. CITA: Int J Surg Pathol. 2015 Feb; 23(1):13-9 DOI: 10.1177/1066896914542125 TÍTULO: Air pollution and your brain: what do you need to know right now AUTORES: Calderón-Garcidueñas L, Calderón-Garcidueñas A, Torres-Jar- dón R, Avila-Ramírez J, Kulesza RJ, Angiulli AD. SUMMARY: Research links air pollution mostly to respiratory and cardio- vascular disease. The effects of air pollution on the central nervous system (CNS) are not broadly recognized. Urban outdoor pollution is a global pub- lic health problem particularly severe in megacities and in underdeveloped countries, but large and small cities in the United States and the United Kingdom are not spared. Fine and ultrafine particulate matter (UFPM) de- fined by aerodynamic diameter (<2.5-μm fine particles, PM2.5, and <100-nm UFPM) pose a special interest for the brain effects given the capability of very small particles to reach the brain. In adults, ambient pollution is asso- ciated to stroke and depression, whereas the emerging picture in children show significant systemic inflammation, immune dysregulation at systemic, intratechal and brain levels, neuroinflammation and brain oxidative stress, along with the main hallmarks of Alzheimer and Parkinson's diseases: hy- perphosphorilated tau, amyloid plaques and misfolded α-synuclein. Animal models exposed to particulate matter components show markers of both neuro inflammation and neurodegeneration. Epidemiological, cognitive, be- havioral and mechanistic studies into the association between air pollution exposures and the development of CNS damage particularly in children are of pressing importance for public health and quality of life. Primary health providers have to include a complete prenatal and postnatal environmental and occupational history to indoor and outdoor toxic hazards and measures should be taken to prevent or reduce further exposures. CITA: Prim Health Care Res Dev. 2015 Jul; 16(4):329-45 DOI: 10.1017/S146342361400036X TÍTULO: Alternative bibliometrics from impact factor improved the esteem of a journal in a 2-year-ahead annual-citation calculation: multivariate analysis of gastroenterology and hepatology journals AUTORES: Roldan-Valadez E, Rios C. INTRODUCTION: A deeper understanding of supplementary bibliometrics beyond the impact factor might provide researchers with a better under- standing of the citation process. This study presents a multivariate analysis 169

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 25533546 of gastroenterology and hepatology journals to evaluate the predictive ability of seven bibliometrics in the Web of Science to calculate total cites over a 2-year period. METHODS: Coincidentally, bibliometrics appearing during 2008, 2009, and 2010, with their corresponding cites in 2010, 2011, and 2012, were record- ed from the Journal Citation Reports Science Edition. A linear mixed-effects design using random slopes and intercepts was performed on 51 out of 74 journals in the Gastroenterology and Hepatology category. RESULT: There was a significant global effect size (R(2) = 0.992; P < 0.001),which yielded a total variance of 99.2%. The strongest predictors in the model were the Eigen factor Score and Cited Half-life (P < 0.001), fol- lowed by the Number of Articles (P = 0.011) and the Immediacy Index (P = 0.021). The impact factor was not a significant predictor. CONCLUSION: The Eigen factor Score and Cited Half-life predictors might be the new standards to assess the influence and importance of scientific journals; this approach may help researchers select journals in which to pub- lish their work. CITA: Eur J Gastroenterol Hepatol. 2015 Feb; 27(2):115-22 DOI: 10.1097/MEG.0000000000000253 TÍTULO: The importance of the interaction between hepatocyte and hepatic stellate cells in fibrogenesis induced by fatty accumulation AUTORES: Giraudi PJ, Becerra VJ, Marin V, Chavez-Tapia NC, Tiribelli C, Rosso N. BACKGROUND & AIMS: Non-alcoholic fatty liver disease is characterized by an initial accumulation of triglycerides that can progress to non-alcoholic steatohepatitis, which can ultimately evolve to cirrhosis and hepatocellular carcinoma. Hepatic stellate cells play a key role in liver fibrogenesis by an increased activation and an altered profile of genes involved in the turnover of extracellular matrix components. To reproduce in-vitro the functional cell connections observed in vivo it is essential to consider cell-to-cell proximity and interaction. The aim of this study was to determine the response to free fatty acids in a simultaneous co-culture model of hepatocytes and hepatic stellate cells. METHODS: Simultaneous co-culture model and monoculture of each cell type(control) were exposed to FFA for 24 up to 144 h. Quantification of ste- atosis; stellate cell activation; assessment of fibrogenic response; expres- sion and activity of metalloproteinases as well as collagen biosynthesis were evaluated. RESULTS: Free fatty acids induced comparable steatosis in simultaneous co-culture and monoculture. However, the activation of the stellate cells as- sessed by alpha-smooth muscle actin expression is greater when cells were in close contact. Furthermore, a time-dependent increment of tissue inhibitor metalloproteinase-2protein was observed, which was inversely correlated with protein expression and activity of matrix-metalloproteinases, suggesting en- hanced collagen biosynthesis. This behavior was absent in cell monoculture. CONCLUSIONS: These data indicate that cell-to-cell proximity between hepatocytes and stellate cells is necessary for the initiation of the fibrotic process. 170

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR CITA: Exp Mol Pathol. 2015 Feb; 98(1):85-92 DOI: 10.1016/j.yexmp.2014.12.006 PMID: 25536638 TÍTULO: Portal vein thrombosis: what is new? PMID: 25536641 AUTORES: Manzano-Robleda M del C, Barranco-Fragoso B, Uribe M, Méndez-Sánchez N. SUMMARY: Portal vein thrombosis (PVT) is one of the most common vascu- lar disorders of the liver with significant morbidity and mortality. Large cohort studies have reported a global prevalence of 1%, but in some risk groups it can be up to 26%. Causes of PVT are cirrhosis, hepatobiliary malignancy, abdominal infectious or inflammatory diseases, and myeloproliferative dis- orders. Most patients with PVT have a general risk factor. The natural his- tory of PVT results in portal hypertension leading to splenomegaly and the formation of portosystemic collateral blood vessels and esophageal, gastric, duodenal, and jejunal varices. Diagnosis of PVT is made by imaging, mainly Doppler ultrasonography. According to its time of development, localization, pathophysiology, and evolution, PVT should be classified in every patient. Some clinical features such as cirrhosis, hepatocellular carcinoma, and he- patic transplantation are areas of special interest and are discussed in this review. The goal of treatment of acute PVT is to reconstruct the blocked veins. Endoscopic variceal ligation is safe and highly effective in patients with variceal bleeding caused by chronic PVT. In conclusion, PVT is the most common cause of vascular disease of the liver and its prevalence has being increasing, especially among patients with an underlying liver disease. All patients should be investigated for thrombophilic conditions, and in those with cirrhosis, anticoagulation prophylaxis should be considered. CITA: Ann Hepatol. 2015 Jan-Feb; 14(1):20-7 DOI: 10.1016/S1665-2681(19)30797-5 TÍTULO: Boceprevir and telaprevir for chronic genotype 1 hepatitis C virus infection. A systematic review and meta-analysis AUTORES: Manzano-Robleda M del C, Ornelas-Arroyo V, Barrien- tos-Gutiérrez T, Méndez-Sánchez N, Uribe M, Chávez-Tapia NC. BACKGROUND: Treatment of hepatitis C virus (HCV) infection with newer direct-acting antivirals is unrealistic in some countries because of the lack of availability. AIM: Assess benefits and harms of boceprevir (BOC) and telaprevir (TLV) in treatment of genotype 1 HCV infection, and identifying subgroups with most benefit. MATERIAL AND METHODS: Search from 2009-2013 in PubMed, EMBASE, and \"gray literature\" of published and unpublished randomized trials report- ing sustained viral response (SVR) or adverse events (AE) with BOC or TLV + pegylated interferon and ribavirin (PR) in HCV-infected patients; cohorts or case reports for comparison protease inhibitors (PI), evaluation of pre- dictors of SVR, and resistant variants. Cochrane guidelines were applied. Comparisons between PI + PRvs. PR were performed. Main outcomes were expressed as risk-ratios with 95% CIs. Meta-regression and trial sequential analysis were performed. 171

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR RESULTS: 33 studies (10,525 patients) were analyzed. SVR was higher for PI + PR (RR, 2.05; 95% CI 1.70-2.48). In meta-regression, previously treat- ed patients exhibited greater benefit from PI + PR (RR, 3.47; 95% CI, and 2.78-4.33). AE were higher with PI + PR (RR, 1.01; 95% CI, 1-1.03; NNH 77.59), also the discontinuation rate (RR, 1.69; 95% CI, 1.36-2.10, NNH, 18). Predictors of SVR were IL-28 TT, nonblack race, low viral load, age, no cir- rhosis, statin use, undetectable viral load at the first anemia episode and at week 2 of treatment, and low IL-6 levels. In conclusion SVR was higher in patients treated with PIs, patients previously exposed to PR showed superi- or response rates. Specific predictors will determine the best candidates for treatments that will of ferreal-life therapeutic alternatives. CITA: Ann Hepatol. 2015 Jan-Feb;14(1):46-57 DOI: 10.1016/S1665-2681(19)30800-2 PMID: 25536646 TÍTULO: Thrombosis and hemorrhage in the critically ill cirrhotic patients: PMID: 25542236 five years retrospective prevalence study AUTORES: Muciño-Bermejo J, Carrillo-Esper R, Méndez-Sánchez N, Uribe M. BACKGROUND: Cirrhotic patients present a complex interaction between deficient synthetic liver function, hemodynamic abnormalities and superim- posed conditions that alter coagulation system. This alters both coagulation and fibrinolytic processes, increasing bleeding and thrombosis risks. Partic- ularly, critically ill cirrhotic patients represent a diagnostic challenge since they have multiple comorbidities making the thrombotic and bleeding risks unpredictable. The prevalence of bleeding and thrombosis in this subset of patients remains poorly described. The main aim of this article is to describe the prevalence of thrombotic and hemorrhagic complications in cirrhotic pa- tients admitted between2007 and 2012 at Médica Sur Clinic and Foundation ICU. MATERIAL AND METHODS: We performed a five years retrospective study including every cirrhotic patient admitted to ICU between January 2007 and December 2012. RESULTS: The incidence of hemorrhage was 48.5%, the overall incidence of thrombotic complications was 13.66%. Variceal bleeding was the most prevalent hemorrhagic event and portal vein thrombosis the most common thrombotic event. Factors associated with presenting a bleeding episode included kidney injury, infection and thrombosis. Factors associated with in- creased thrombotic risk included ascites, infection and bleeding. CONCLUSION: Critically ill cirrhotic patients have an high risk for both thrombotic and bleeding episodes. The association between the presence of bleeding and thrombotic events was statistically significant. CITA: Ann Hepatol. 2015 Jan-Feb; 14(1):93-8 DOI: 10.1016/S1665-2681(19)30805-1 TÍTULO: Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) prognostic value in lung adenocarcinoma AUTORES: Ruiz-Morales JM, Dorantes-Heredia R, Arrieta O, Chávez-Ta- pia NC, Motola-Kuba D. 172

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR SUMMARY: Prognosis in patients with lung cancer is poor. Neutrophil gelati- nase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) are proteins involved in the invasion and metastases of cancer. The objec- tive of this study is to determine if there is a relationship between tumor ex- pression of NGAL and MMP-9 in lung adenocarcinoma patients with progno- sis and overall survival. Retrospective analysis was made of patients with lung adenocarcinoma treated at Medica Sur Hospital between 2005 and 2013. Tumor tissue was analyzed for NGAL andMMP-9 expression by immu- nohistochemistry. We identified 41 patients. Mean overexpression in tumoral tissue of NGAL was 70 % and 30 % for MMP-9. Univariate analysis revealed that prognostic factors associated with overall survival (OS) were NGAL expression and stage at diagnosis. Median OS for NGAL expression < 70 %was 45.7 months (95 % CI; 15.2-76.2) and for patients with ≥ 70 % 4.6 months (95 % CI; 0.5-18.8; P < 0.0001), and for stage at diagnosis (stages I and II mean not reached), stage III mean OS 15.57 months (95 % CI; 9.8- 21.2) and stage IV 9.6months (95 % CI; 0.8-18.4. P = 0.002). No differences in OS were found for expression of MMP-9. Multivariate analysis revealed significance for OS in NGAL expression (HR 5.01 [95 % CI; 1.68-14.93] P = 0.004) and stage at diagnosis (HR2.05 [95 % CI 1.30-3.22] P = 0.002). Tumoral tissue expression of NGAL ≥ 70 %confers a worse prognosis com- pared to those who did not. NGAL is an independent prognostic factor of stage at diagnosis. CITA: Tumour Biol. 2015 May; 36(5):3601-10 DOI: 10.1007/s13277-014-2997-3 PMID: 25597287 TÍTULO: A genetic risk score is associated with hepatic triglyceride content and non-alcoholic steatohepatitis in Mexicans with morbid obesity AUTORES: León-Mimila P, Vega-Badillo J, Gutiérrez-Vidal R, Villamil-Ramí- rez H, Villareal-Molina T, Larrieta-Carrasco E, López-Contreras BE, Kauffer LR, Maldonado-Pintado DG, Méndez-Sánchez N, Tovar AR, Hernández- -Pando R, Velázquez-Cruz R, Campos-Pérez F, Aguilar-Salinas CA, Cani- zales-Quinteros S. BACKGROUND AND AIMS: Genome-wide association studies have identi- fied single nucleotide polymorphisms (SNPs) near/in PNPLA3, NCAN, LYP- LAL1, PPP1R3B, and GCKR genes associated with non-alcoholic fatty liver disease (NAFLD) mainly in individuals of European ancestry. The aim of the study was to test whether these genetic variants and a genetic risk score (GRS) are associated with elevated liver fat content and non-alcoholic ste- atohepatitis (NASH) in Mexicans with morbid obesity. METHODS: 130 morbidly obese Mexican individuals were genotyped for six SNP sin/near PNPLA3, NCAN, LYPLAL1, PPP1R3B, and GCKR genes. He- patic fat content [triglyceride (HTG) and total cholesterol (HTC)] was quanti- fied directly in liver biopsies and NASH was diagnosed by histology. A GRS was tested for association with liver fat content and NASH using logistic regression models. In addition, 95ancestry-informative markers were geno- typed to estimate population admixture proportions. RESULTS: After adjusting for age, sex and admixture, PNPLA3, LYPLAL1, GCKR andPPP1R3B polymorphisms were associated with higher HTG con- tent (P < 0.05 forPNPLA3, LYPLAL1, GCKR polymorphisms and P = 0.086 for PPP1R3B). The GRS was significantly associated with higher HTG and HTC content (P = 1.0 × 10(-4) and0.048, respectively), steatosis stage (P = 173

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR 0.029), and higher ALT levels (P =0.002). Subjects with GRS ≥ 6 showed a significantly increased risk of NASH (OR =2.55, P = 0.045) compared to those with GRS ≤ 5. However, the GRS did not predict NASH status, as AUC of ROC curves was 0.56 (P = 0.219). CONCLUSION: NAFLD associated loci in Europeans and a GRS based on these loci contribute to the accumulation of hepatic lipids and NASH in mor- bidly obese Mexican individuals. CITA: Exp Mol Pathol. 2015 Apr; 98(2):178-83 DOI: 10.1016/j.yexmp.2015.01.012 PMID: 25671841 TÍTULO: The role of small heterodimer partner in hepatic lipid homeostasis AUTORES: Barranco-Fragoso B, Almeda-Valdes P, Aguilar-Olivos N, Méndez-Sánchez N. SUMMARY: Letter to the editor CITA: Ann Hepatol. 2015 Mar-Apr; 14(2):286-7 DOI: 10.1016/S1665-2681(19)30794-XGet PMID: 25700580 TÍTULO: The ACE I/D polymorphism is associated with nitric oxide metabo- lite and blood pressure levels in healthy Mexican men AUTORES: Avila-Vanzzini N, Posadas-Romero C, Gonzalez-Salazar Mdel C, Maass-Iturbide C, Melendez-Ramirez G, Perez-Mendez O, Del Val- le-Mondragon L, Masso-Rojas F, Varela Lopez E, Herrera-Bello H, Villavi- cencio Fernandez R, Cruz-Robles D. BACKGROUND: The I/D insertion/deletion polymorphism of the angioten- sin-converting enzyme has been related to hypertension. This polymorphism also seems to have gender related implications. Angiotensin II contributes to the production and release of oxygen reactive species that react with nitric oxide, inactivating its effects. OBJECTIVE: To establish whether the ACE I/D polymorphism correlates with nitric oxide plasma metabolites in healthy men and women. METHODS: Among 896 subjects between 18 and 30 years of age range, 138 fulfilledinclusion criteria. The polymorphism was identified by poly- merase chain reaction, and blood nitric oxide metabolites were analyzed following the method described by Bryan. RESULTS: Both systolic and diastolic arterial pressures were higher in men than in women (107/67 vs. 101/65 mm Hg, p<0.001). In terms of the ACE gene, there were differences in the concentration of nitric oxide metabolites in men with the I/D and D/D genotypes when compared to carriers of the I/I genotype (33.55 and 29.23 vs. 53.74 pmol/ml; p=<0.05), while there were no significant differences in women when compared by genotype. Men with the D/D genotype had higher systolic blood pressure than I/D carriers (111 vs. 104 mm Hg, p<0.05). We observed no arterial blood pressure differences in women when grouped by ACE genotype. 174

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR CONCLUSIONS: The ACE D/D genotype was associated with nitric oxide metabolite levels and systolic blood pressure in clinically healthy men while it had no effect in women. CITA: Arch Cardiol Mex. 2015 Apr-Jun; 85(2):105-10 DOI: 10.1016/j.acmx.2014.12.005 PMID: 25722101 TÍTULO: Paradoxical response to tuberculosis treatment producing bowel obstruction AUTORES: Medina-Franco H, Pimienta-Ibarra AS, Dorantes-Heredia R, Nuñez-Gómez J, Pastor-Sifuentes FU. SUMMARY: Case report CITA: Int J Colorectal Dis. 2015 Dec; 30(12):1749-50 DOI: 10.1007/s00384-015-2170-5 PMID: 25757447 TÍTULO: Factors Associated with the Quality of Transient Elastography AUTORES: Juárez-Hernández E, Uribe-Ramos MH, Ramos-Ostos MH, López-Ramírez AY, Ornelas-Arroyo S, Romero-Flores JL, Méndez-Sán- chez N, Uribe M, Chávez-Tapia NC. BACKGROUND: Transient elastography is a noninvasive method for the evaluation of fibrosis in chronic liver disease. However, its reliability is vari- able, and the factors associated with its accuracy have not been identified completely. AIMS: To identify the factors associated with the reliability of transient elas- tography. METHODS: A total of 2033 transient elastography measurements were tak- en from March 2009 to October 2013. Reliability was determined according to the interquartile range/median (IQR/M < 0.30 = reliable; IQR/M < 0.10 = very reliable). Other indicators such as the percentage of successful mea- surements (>60 %), time of performance, and probe size were recorded. Po- tential factors that could affect the reliability of the procedure were analyzed using multivariate logistic regression. RESULTS: Slightly less than 5 % of the measurements were unsuccessful, and 83 %of the successful measurements were found to be reliable. Fac- tors associated with an unsuccessful measurement were female gender, incorrect probe size, and the presence of HCV infection. Unreliable mea- surements were associated with use of the procedure as part of a clinical study and success rate. Very reliable evaluations were associated with >10 measurements, the presence of chronic hepatic disease, and a success rate of >60 %. CONCLUSIONS: The operator and clinical and anthropometric characteris- tics are factors that influence the success and reliability of transient elastog- raphy. Improvements in the quality of the procedure are needed to provide better diagnostic accuracy in clinical practice. CITA: Dig Dis Sci. 2015 Jul; 60(7):2177-82 DOI: 10.1007/s10620-015-3611-2 175

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 25792461 TÍTULO: Cystadenomas of the liver and extrahepatic bile ducts: Morpho- logic and immunohistochemical characterization of the biliary and intestinal variants AUTORES: Albores-Saavedra J, Córdova-Ramón JC, Chablé-Montero F, Dorantes-Heredia R, Henson DE. SUMMARY: Cystadenomas of the liver and extrahepatic bile ducts (EHBD) are uncommon but distinctive neoplasms whose terminology and epithelial phenotype have been a source of controversy. We reviewed 20 cases, 16 arising in the liver and 4 in the EHBD. Eighteen patients were women, with a mean age of 36.5 years. Eighteen tumors were multi loculated and 2 were uni locular. The tumor size ranged from 4 to29 cm (average, 11 cm). The cyst fluid in 13 tumors was described as serous, in 2as clear, in 2 others as hemorrhagic, and in 1 as serous and mucinous. Only in 2 tumors was the fluid described as mucinous. In 18 cystadenomas, the predominant epithe- lial lining consisted of a single layer of cuboidal or low-columnar non dys- plastic cells similar to those of the gallbladder or bile ducts. This epithelial lining was strongly positive for cytokeratins 7 and 19, and focally positive for MUC1. Only 2 cystadenomas showed predominant intestinal differentiation characterized by mature goblet cells and columnar absorptive cells. These cells expressed CDX2, MUC2, and cytokeratin 20. Admixed with the goblet and columnar cells, there were serotonin-containing cells and Paneth cells. These 2 tumors showed extensive areas of high-grade dysplasia and invasive adenocarcinoma with intestinal phenotype. A subepithelial ovarian-like stro- ma was present in all tumors. None of the patients died of the tumors. We be- lieve that the term mucinous cystic tumor recommended by the World Health Organization for all cystadenomas of the liver and EHBD is a misnomer. CITA: Ann Diagn Pathol. 2015 Jun; 19(3):124-9 DOI: 10.1016/j.anndiagpath.2015.03.001 PMID: 25809744 TÍTULO: Perfusion volume correlates, percentage of involution, and clinical efficacy at diverse follow-up survey times after MR-guided focused ultra- sound surgery in uterine fibroids: first report in a Mexican mestizo popula- tion AUTORES: Carrasco-Choque AL, Lara YF, Vivas-Bonilla I, Romero-Tre- jo C, Villa AR, Roldan-Valadez E. OBJECTIVES: To evaluate the clinical efficacy of magnetic resonance-guid- ed focused ultrasound surgery in a Mexican mestizo population. METHODS: This retrospective study included 159 women (mean age 37 ± 6.4 years, range 22-53 years) from 2008 to 2010. Two hundred six- ty-eight symptomatic uterine fibroids were treated using MR-guided focused ultrasound surgery. Parameters included initial perfused volume, final per- fused volume, non-perfused volume (NPV), and treated volume ratio (TVR). Follow-up up to 15 months assessed treatment efficacy and symptomatic re- lief. Non-parametric statistics and the Kaplan-Meier method were performed. RESULTS: T2-weighted hypo intense fibroids showed a frequency of 93.6%; isointense and hyper intense fibroids had frequencies of 5.60 and 1.1%. There was a negative correlation between NPV and age (r = -0.083, p = 0.307) and treatment time(r = -0.253, p = 0.001). Median TVR was 96.0% in small fibroids and 76.5% in large fibroids. Involution of 50% and 80% was achieved at months 6-7 and month11, respectively. Relief of symptoms was significant (p < 0.05). 176

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR CONCLUSIONS: Our data show that higher TVR attained immediately post-treatment of MRg FUS favours higher involution percentages at fol- low-up; however, careful patient selection and use of pretreatment imaging are important components for predicting success using MR-guided focused ultrasound surgery. KEY POINTS: • Type 1 fibroids were the most common (93.2%). • Age and treated volume were not correlated (r s   = -0.215, p = 0.165). • Small fibroids achieved a higher treated volume than large (96.0% vs. 76.5%). • A 50% involution was achieved at 6-month follow-up for type-1 fibroid. • A decrease of 80% was reached at 11 months for type-1 fibroids. CITA: Eur Radiol. 2015 Oct; 25(10):2905-12 DOI: 10.1007/s00330-015-3707-2 PMID: 25818035 TÍTULO: [Hypereosinophilic syndrome with cardiogenic shock: First Mexican case] AUTORES: Anguiano-Alvarez VM, Troyo-Barriga P, de la Peña R, García-Graullera M, Gutiérrez-Romero A. SUMMARY: Case report CITA: Arch Cardiol Mex. 2015 Jul-Sep; 85(3):259-61 DOI: 10.1016/j.acmx.2015.01.002 PMID: 25864226 TÍTULO: Papillary in situ and intramucosal adenocarcinoma of the lower third of common bile duct. A report and review of the literature AUTORES: Montalvo-Javé EE, Chablé-Montero F, Toapanta-Yancha- paxi LN, Rojas-Mendoza F, López-Caballero C, Roca-Cabrera ML, Mendo- za-Barrera GE. SUMMARY: We report the case of a 37-year-old woman with no relevant medical history. She was admitted to the hospital for epigastric pain related with food intake for 4days; the pain did not improve with symptomatic man- agement. A laparoscopic cholecystectomy due to acute lithiasic cholecystitis was performed. However, after 4 days, postoperative painless jaundice was evident; thus, endoscopic retrograde cholangiopancreatography was per- formed, which revealed an amputation of intra pancreatic common bile duct, as well as secondary intra- and extra hepatic bile duct dilatation. Brushing of the distal portion of the common bile duct revealed a well-differentiated adenocarcinoma. Therefore, a Whipple procedure with pylorus preservation was performed. Pathologic diagnosis of a papillary in situ adenocarcinoma with two microscopic foci of micro invasion was established. The pathologic Tumor-Node-Metastasis (TNM) stage was pT1, pN0, pM0, R0. The patient is asymptomatic and disease-free 24 months after surgery. In general, ade- nocarcinomas of the extrahepatic bile ducts are uncommon and have a poor prognosis. However, symptomatic patients with early disease stages are even rarer and can be cured surgically. CITA: Ann Hepatol. 2015 May-Jun; 14(3):425-9 DOI: 10.1016/S1665-2681(19)31285-2 177

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 25864228 TÍTULO: In Memoriam Paul Angulo PMID: 25902919 AUTORES: Méndez-Sánchez N. SUMMARY: Letter to the editor CITA: Ann Hepatol. 2015 May-Jun; 14(3):433-4 DOI: 10.1016/S1665-2681(19)31287-6 TÍTULO: Selected Gray Matter Volumes and Gender but Not Basal Ganglia nor Cerebellum Gyri Discriminate Left Versus Right Cerebral Hemispheres: Multivariate Analyses in human Brains at 3T AUTORES: Roldan-Valadez E, Suarez-May MA, Favila R, Aguilar-Cas- tañeda E, Rios C. SUMMARY: Interest in the lateralization of the human brain is evident through a multidisciplinary number of scientific studies. Understanding vol- umetric brain asymmetries allows the distinction between normal develop- ment stages and behavior, as well as brain diseases. We aimed to evalu- ate volumetric asymmetries in order to select the best gyri able to classify right- versus left cerebral hemispheres. A cross-sectional study performed in 47 right-handed young-adults healthy volunteers. SPM-based software per- formed brain segmentation, automatic labeling and volumetric analyses for 54 regions involving the cerebral lobes, basal ganglia and cerebellum from each cerebral hemisphere. Multivariate discriminant analysis (DA) allowed the assembling of a predictive model. DA revealed one discriminant func- tion that significantly differentiated left vs. Right cerebral hemispheres: Wilks' λ = 0.008, χ(2) (9) = 238.837, P < 0.001. The model explained 99.20% of the variation in the grouping variable and depicted an overall predictive accuracy of 98.8%. With the influence of gender; the selected gyri able to discriminate between hemispheres were middle orbital frontal gyrus(g.), angular g., supra marginal g., middle cingulum g., inferior orbital frontal g., calcarine g., infe- rior parietal lobule and the pars triangular is inferior frontal g. Specific brain gyri are able to accurately classify left vs. right cerebral hemispheres by us- ing a multivariate approach; the selected regions correspond to key brain areas involved in attention, internal thought, vision and language; our find- ings favored the concept that lateralization has been evolutionary favored by mental processes increasing cognitive efficiency and brain capacity. CITA: Anat Rec (Hoboken). 2015 Jul;298(7):1336-46 DOI: 10.1002/ar.23165 PMID: 25922696 TÍTULO: Second-line treatment in EGFR-unselected patients: is it time to close one arm of this river's DELTA? AUTORES: Morales-Espinosa D, Rosell R. SUMMARY: Editorial CITA: J Thorac Dis. 2015 Mar; 7(3):227-9 DOI: 10.3978/j.issn.2072-1439.2015.01.34 178

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 25983318 TÍTULO: Mexican consensus on the diagnosis and management of hepatitis C infection AUTORES: Sánchez-Ávila JF, Dehesa-Violante M, Méndez-Sánchez N, Bosques-Padilla F, Castillo-Barradas M, Castro-Narro G, Cisneros-Garza L, Chirino-Sprung RA, García-Juarez I, Gonzalez-Huezo MS, Malé-Velazquez R, Moreno-Alcántar R, Muñoz-Espinoza L, Ramos-Gómez M, Rizo-Robles MT, Sandoval-Salas R, Sierra-Madero J, Torres-Ibarra Mdel R, Vazquez- Frias R, Wolpert-Barraza E INTRODUCTION: Chronic hepatitis due to hepatitis C (HCV) viral infection is one of the main causes of chronic liver disease in the world. In the near fu- ture, the number of cases developing complications is expected to rise and include the following: liver cirrhosis, liver failure (ascites, encephalopathy, spontaneous bacterial peritonitis, variceal hemorrhage), hepatocellular car- cinoma, death or the need for liver transplantation. However, research in the field of hepatitis C diagnosis and treatment is one of the most active special- ly on the development of new therapeutic strategies potentially offering bet- ter viral eradication rates and fewer adverse events. Although this disease is a frequent cause of consultation and hospitalization, data published in our country are insufficient. The last guidelines proposed by a medical associa- tion in Mexico were published in 2007 and those suggested by the General Council of Health were published in 2009. The aim of this study group was to analyze the available evidence on the diagnosis and treatment of hepatitis C in the Mexican population, in the context of published international clinical and therapeutic guidelines, in order to issue recommendations that are appli- cable in our midst. The Mexican Association of Hepatology convened a work group in Mexico City, on April 25th and 26th, 2014. Twenty specialists with particular interest and experience. METHODOLOGY: We conducted an electronic database search in English and Spanish to identify all published documents since the year 2000 that included the terms epidemiology, hepatitis C, diagnosis, treatment, therapy, liver cirrhosis, liver transplantation and Mexico. Previously dated documents were included if they were of particular relevance, as were abstracts pre- sented in national meetings and international guidelines published by the World Health Organization or various medical associations. The bibliography was provided to all panelists before the meeting and was complemented by references suggested by each member of the consensus group. The group was divided into five working subgroups: 1. Disease impact and at-risk groups. 2. Diagnostic and therapeutic assessment. 3. Treatment of subjects with no previous therapy. 4. Management of subjects with treatment failure. 5. Management of special situations A document was generated from each discussion subject and practical recommendations were proposed; each was assigned a level of evidence following the GRADE system (Grading of Recommendations, Assessment, Development and Evaluation System). The quality of the evidence is thus classified in three possible levels: high [A], moderate [B] or low [C] and either strong [1] or weak [2] (see Table 1). The proposed recommendations were presented to all panelists to obtain their comments and observations. Finally, a second work meeting was conducted in Mexico City on July 19th, 2014, in order to present the final document to the members of the consensus group for their review and approval. The following are the documents presented by each working team with their proposed recommendations and grades of evidence. This document will be updated periodically as medical advances and regulatory aspects permit the use of new treatments in our country. CITA: Ann Hepatol. 2015; 14 Suppl 1:5-48 DOI: 10.1016/S1665-2681(19)30815-4 179

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 26019035 TÍTULO: The nuclear receptor FXR, but not LXR, up-regulates bile acid PMID: 26019039 transporter expression in non-alcoholic fatty liver disease AUTORES: Aguilar-Olivos NE, Carrillo-Córdova D, Oria-Hernán- dez J, Sánchez-Valle V, Ponciano-Rodríguez G, Ramírez-Jaramillo M, Chablé-Montero F, Chávez-Tapia NC, Uribe M, Méndez-Sánchez N. BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most com- mon cause of chronic liver disease. Patients with non-alcoholic steatohepa- titis (NASH) have increased plasmatic and hepatic concentrations of bile ac- ids (BA), suggesting that they can be associated with the progression of the disease. Hepatic nuclear receptors are known to modulate genes controlling BA metabolism; thus, in this work we aimed to compare the expression of liver nuclear receptors -farnesoid X(FXR), small heterodimer partner (SHP) and liver X alpha (LXRα) receptors- and BA transporters -sodium+/taurocho- late co transporting polypeptide (NTCP) and bile salt export pump (BSEP)- in liver biopsy samples of patients with simple steatosis (SS) and NASH. MATERIAL AND METHODS: Forty patients with biopsy-proven NALFD were enrolled between 2009 and 2012; liver biopsies were classified as SS (N = 20) or NASH (N =20) according to the NAFLD activity score. Gene expression of nuclear FXR, LXRα, SHP, NTCP and BSEP was analyzed by real-time reverse transcription polymerase chain reaction and protein level was quantified by western blot. RESULTS: Gene expression of FXR, SHP, NTCP and BSEP was signifi- cantly up-regulated in the NASH group in comparison with SS patients (P < 0.05). In contrast, protein level for FXR, SHP and NTCP was decreased in the NASH patients vs. the SS group (P < 0.05). Gene and protein profile of LXRα did not show differences between groups. CONCLUSIONS: The results suggest that liver nuclear receptors (FXR and SHP) and BA transporters (NTCP and BSEP) are associated with the pro- gression of NAFLD. CITA: Ann Hepatol. 2015 Jul-Aug; 14(4):487-93 DOI: 10.1016/S1665-2681(19)31170-6 TÍTULO: Prevalence in vulnerable population of liver fibrosis identified by transient elastography AUTORES: Chávez-Tapia N, Torres-Sánchez J, Romero-Flores J, Álva- rez-Quiroz P, Ramírez-Álvarez S, Juárez-Hernández E, Pérez-Jáuregui J, Méndez-Sánchez N, Uribe M. BACKGROUND: Transient elastography (TE) is a useful tool for the assess- ment of hepatic fibrosis as an alternative to liver biopsy, but it has not been validated as a screening procedure in apparently healthy people. AIM: To determine the prevalence of advanced liver fibrosis diagnosed by TE in a socioeconomically challenged rural population. MATERIAL AND METHODS: We enrolled 299 participants aged over 18 years old from a vulnerable population in Mexico who responded to an open invitation. All participants had their history recorded and underwent a gen- eral clinical examination and a liver stiffness measurement, performed by a single operator according to international standards. 180

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR RESULTS: Overall, 7.35% participants were found to be at high risk for cirrhosis. Three variables correlated with a risk for a TE measure ≥ 9 kPa and significant fibrosis: history of alcohol intake [7.95 vs. 92.04%, odds ratio (OR) 4.47, 95%confidence interval (CI) 1.45-13.78, P = 0.0167], body mass index (BMI) ≥ 30kg/m2 (30.87 vs. 69.12%, OR 4.25, 95%CI 1.04-6.10, P = 0.049), and history of diabetes mellitus (14.87 vs. 85.12%, OR 2.76, 95%CI 1.002-7.63, P = 0.0419). In the multivariate analyses BMI ≥ 30 kg/m2 was the only significant risk factor for advanced liver fibrosis or cirrhosis (OR 2.54, 95%CI 1.02-6.3, P = 0.0460). CONCLUSION: TE could be useful as a screening process to identify ad- vanced liver fibrosis in the general and apparently healthy population. CITA: Ann Hepatol. 2015 Jul-Aug; 14(4):524-30 DOI: 10.1016/S1665-2681(19)31174-3 PMID: 26019041 TÍTULO: Combined high-fat diet and sustained high sucrose consumption promotes NAFLD in a murine model AUTORES: Torres-Villalobos G, Hamdan-Pérez N, Tovar AR, Ordaz-Nava G, Martínez-Benítez B, Torre-Villalvazo I, Morán-Ramos S, Díaz-Villaseñor A, Noriega LG, Hiriart M, Medina-Santillán R, Castillo-Hernandez M del C, Méndez-Sánchez N, Uribe M, Torres N. BACKGROUND: The study of NAFLD in humans has several limitations. Using murine models helps to understand disease pathogenesis. AIM: Evaluate the impact of 4 different diets in the production of NAFLD with emphasis on a combined high-fat plus sustained high sucrose consumption. MATERIAL AND METHODS: Eight week-old male Wistar rats were divided in four group sand fed for 90 days with the following diets: 1) Control chow diet (C); 2) High-fat cholesterol diet (HFC) + 5% sucrose in drinking water. 3) High-fat cornstarch diet (HFCO) + 5% sucrose in drinking water. 4) Chow diet + 20% sucrose in drinking water (HSD). Metabolic changes, leptin levels, liver histology, hepatic and plasma lipid composition, fasting plasma glucose and insulin and liver gene expression of FAS, SREBP-1 and PPAR-α were evaluated. RESULTS: The HFC diet had the highest grade of steatosis (grade 2 of 3) and HSD showed also steatosis (grade 1). Liver weight TG and choles- terol concentrations in liver were greater in the HFC diet. There were no increased levels of iron in the liver. Rats in HFC gained significantly more weight (P < 0.001). All experimental groups showed fasting hyperglycemia. HFC had the highest glucose level (158.5 ± 7mg/dL) (P < 0.005). The HSD and the HFCO diets developed also hyperglycemia. HSD had significantly higher fasting hyperinsulinemia. Serum leptin was higher in the HFC diet (p = 0.001). In conclusion, the HFC diet with combination of high fat and high sucrose is more effective in producing NAFLD compared with a high sucrose diet only. CITA: Ann Hepatol. 2015 Jul-Aug; 14(4):540-6 DOI: 10.1016/S1665-2681(19)31176-7 181

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 26019047 TÍTULO: Insights in non-alcoholic fatty liver disease pathophysiology with PMID: 26023324 lipidomic analyses AUTORES: Almeda-Valdes P, Altamirano-Barrera A, Méndez-Sánchez N. SUMMARY: Letter to the editor CITA: Ann Hepatol. 2015 Jul-Aug; 14(4):567-9 DOI: 10.1016/S1665-2681(19)31182-2 TÍTULO: How an online survey on the treatment of allergic rhinitis and its impact on asthma (ARIA) detected specialty-specific knowledge-gaps AUTORES: Larenas Linnemann DE, Medina Ávalos MA, Lozano Sáenz J. BACKGROUND: To enhance the dissemination of the ARIA document (Al- lergic rhinitis (AR) and its impact on asthma) in Mexico, a Working Group composed of 35specialists of 8 professional medical societies developed a transculturized ARIA México 2014 guideline. The ARIA guidelines use the GRADE system, which builds recommendations and suggestions around clinical questions (CQ). METHODS: As part of the dissemination strategy and to detect the physi- cians' view and knowledge-gaps concerning the treatment of AR an online survey was sent out to members of participating societies containing the CQ of ARIA México. Replies were analyzed per specialty against the ARIA México 2014 experts' recommendations/suggestions; differences between specialties were analyzed with Pearson's Chi-squares. RESULTS: 807 surveys were returned, 657 completed (81%). We analyze replies from 158 alergists, 188 ENTs, 64 pulmonologists, 220 pediatricians and 177 GPs/family doctors. More than half of the surveyed physicians of all specialties would give an allergen reduced diet to pregnant/lactating women and avoid pets at home, which is against ARIA experts' suggestions. ARIA experts suggest intranasal antihistamines can be part of the AR treatment: 46-63% of the ENTs, pulmonologists and pediatricians disagree; and experts prefer oralH1-antihistamines over leukotriene receptor antagonists (LTRA) for the treatment of AR: 52-36% of the pulmonologists, pediatricians and GPs prefer LTRAs. Concerning glucocorticosteroids (GCS): GPs are more reluctant to use intranasal GCS (p < 0.001) and 47% prefers oral H1-anti- histamines. As for the treatment of recalcitrant AR ARIA experts suggest the use of oral, but not intramuscular, GCS: a quarter of pulmonologists, pedia- tricians and GPs considers they should not be used. Contrarily, 40% of ENTs favors intramuscular GCS. In patients with AR and comorbid asthma several physicians of all specialties -except pulmonologists-erroneously considers antihistamines, intranasal GCS and LTRAs useful for the treatment of asth- ma, while first-line recommended asthma treatment is inhaled GCS. CONCLUSION: On certain issues in the treatment of AR the physicians' opinion diverges from the recommendations/suggestions of ARIA experts. Moreover, physicians’ opinions depend on their specialty. As such, an online survey can help to detect knowledge-gaps and guide the development of more focused and specialty-specific postgraduate learning tools. CITA: World Allergy Organ J. 2015 May 19; 8(1):18 DOI: 10.1186/s40413-015-0064-1 182

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 26112485 TÍTULO: Introduction of Dr. Andrew V Schally PMID: 26116038 AUTORES: Mendoza-Valdés A. SUMMARY: Letter to the editor CITA: Asian J Androl. 2015 Nov-Dec; 17(6):923-4 DOI: 10.4103/1008-682X.156852 TÍTULO: [Intestinal obstruction secondary to postoperative adhesion forma- tion in abdominal surgery. Review] AUTORES: Correa-Rovelo JM, Villanueva-López GC, Medina-Santillan R, Carrillo-Esper R, Díaz-Girón-Gidi A. SUMMARY: The development of intestinal obstruction after upper and lower abdominal surgery is part of the daily life of each every surgeon. Despite this, there are very few good quality studies that allow enable assessment of the frequency of intestinal obstruction to be assessed, even although postoper- ative adhesions are the cause of considerable direct and indirect morbidity and its prevention can be considered a public health problem. And yet, in Mexico, at this time, there is no validated recommendation validated on the prevention of adhesions, or more particularly, in connection with the use of a variety of anti-adhesion commercial products which have been marketed for at least a decade. Intraperitoneal adhesions develop between surfaces without peritoneum of the abdominal organs, mesentery, and abdominal wall. The most common site of adhesions is between the greater omentum and anterior abdominal wall previous. Despite the frequency of adhesions and their direct and indirect consequences, just there is only one published a rec- ommendation (from gynaecological literature), regarding peritoneal adhesion prevention. As regards of colorectal surgery, performed more than250, 000 colorectal resections are performed annually in the United States, and from 24% to 35% of them will develop a complication. The clinical and economic financial burden of these complications is enormous, and surgeries colorec- tal surgery been specifically highlighted as a potential point prevention point of surgical morbidity. CITA: Cir Cir. 2015 Jul-Aug; 83(4):345-51 DOI: 10.1016/j.circir.2015.05.024 PMID: 26118780 TÍTULO: [Bilateral brachial plexus block. Case report and systematic re- view] AUTORES: Mejia-Terrazas GE, Garduño-Juárez Mde Á, Limón-Muñoz M, Torres-Maldonado AS, Carrillo-Esper R. BACKGROUND: The bilateral brachial plexus block is considered a contra- indication, due to the possible development of complications, such as: toxici- ty from local anaesthetics or bilateral diaphragmatic paralysis. However, with the real time visualisation provided by the ultrasound scan, these complica- tions have decreased and it is a safer procedure. CLINICAL CASES: Four cases are presented where the bilateral block was performed using guided ultrasound, as the patients were unable to receive general anaesthesia due to a history of adverse effects or the use of opioids 183

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR in the post-operative or by the prediction of a difficult airway associated with obesity. A systematic review of the literature from January 1993 to June 2013, was also performed by using a search in the MEDLINE, EMBASE, ARTEMI- SA, LILACS, Google data bases, in Spanish and English language with the following words: bilateral brachial plexus block, bilateral interscalene block, bilateral infraclavicular block, bilateral supraclavicular block, bilateral lateral supraclavicular block, bilateral axillary block, ultrasound-guided bilateral bra- chial plexus block. CONCLUSION: Based on the evidence found, ultrasound-guided bilateral brachial plexus block in selected patients and expert hands, is no longer a contraindication. CITA: Cir Cir. 2015 Jul-Aug; 83(4):312-8 DOI: 10.1016/j.circir.2015.05.018 PMID: 26140150 TÍTULO: Excessive Weight and Obesity Are Associated to Intra-Ventricular Asynchrony: Pilot Study AUTORES: Ávila-Vanzzini N, Machain Leyva CZ, Rodríguez Castellanos LE, Arias Godínez JA, Ruiz Esparza ME, Herrera Bello H. BACKGROUND: Excessive weight and obesity (EwO) are independent fac- tors in the development of heart failure; they lead to a state of myocardiopa- thy via inflammatory and hormonal mechanisms. If excessively accumulated, epicardial fat favors a pro inflammatory state. Ventricular asynchrony is a marker of heart failure progression and has been poorly studied in EwO. The objective was evaluate the relation between epicardial fat, body mass index (BMI) and mechanical synchrony measured by echocardiography, in healthy individuals with EwO. METHODS: We included 55 healthy individuals between the ages of 18 and 35, 17 had a BMI < 25 kg/m (2) (30.9%) and 38 had a BMI > 25 kg/m (2) (EwO group) (69.09%), anthropometric measurements, transthoracic echo- cardiogram and synchrony evaluation were obtained. RESULTS: Left atrial volume, telediastolic and telesystolic left ventricular volumes and the baseline volume of the right ventricle were greater in the EwO group (20 mL/m (2) vs. 15 mL/m (2), p = 0.001; 106 mL vs. 82 mL, p = 0.0149 vs. 32 mL, p = 0.001 and 34 mm vs. 31 mm, p = 0.02, respectively). The Yu index also correlated with epicardial fat, r = 0.53, p < 0.01, whereby the greater the amount of epicardial fat, the greater the dispersion timing of ventricular activation. The systolic synchrony index also correlated with the BMI, p = 0.01. CONCLUSION: Mechanical intraventricular asynchrony is associated to EwO and the amount of epicardial fat; hence, asynchrony may be one more factor leading to heart failure in EwO individuals. CITA: J Cardiovasc Ultrasound. 2015 Jun; 23(2):86-90 DOI: 10.4250/jcu.2015.23.2.86 PMID: 26148220 TÍTULO: MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhini- tis): the new generation guideline implementation 184

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR AUTORES: Bousquet J, Schunemann HJ, Fonseca J, Samolinski B, Bach- ert C, Canonica GW, Casale T, Cruz AA, Demoly P, Hellings P, Valiulis A, Wickman M, Zuberbier T, Bosnic-Anticevitch S, Bedbrook A, Bergmann KC, Caimmi D, Dahl R, Fokkens WJ, Grisle I, Lodrup Carlsen K, Mullol J, Muraro A, Palkonen S, Papadopoulos N, Passalacqua G, Ryan D, Valovirta E, Yor- gancioglu A, Aberer W, Agache I, Adachi M, Akdis CA, Akdis M, Annesi-Mae- sano I, Ansotegui IJ, Anto JM, Arnavielhe S, Arshad H, Baiardini I, Baigen- zhin AK, Barbara C, Bateman ED, Beghé B, Bel EH, Ben Kheder A, Bennoor KS, Benson M, Bewick M, Bieber T, Bindslev-Jensen C, Bjermer L, Blain H, Boner AL, Boulet LP, Bonini M, Bonini S, Bosse I, Bourret R, Bousquet PJ, Braido F, Briggs AH, Brightling CE, Brozek J, Buhl R, Burney PG, Bush A, Caballero-Fonseca F, Calderon MA, Camargos PA, Camuzat T, Carlsen KH, Carr W, Cepeda Sarabia AM, Chavannes NH, Chatzi L, Chen YZ, Chiron R, Chkhartishvili E, Chuchalin AG, Ciprandi G, Cirule I, Correia de Sousa J, Cox L, Crooks G, Costa DJ, Custovic A, Dahlen SE, Darsow U, De Carlo G, De Blay F, Dedeu T, Deleanu D, Denburg JA, Devillier P, Didier A, Dinh-Xuan AT, Dokic D, Douagui H, Dray G, Larenas-Linnemann D, et al. ABSTRACT: Several unmet needs have been identified in allergic rhini- tis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) is a simple system centered around the patient which was devised to fill many of these gaps using Information and Communications Technology (ICT) tools and a clinical decision support system (CDSS) based on the most widely used guideline in allergic rhinitis and its asthma comorbidity (ARIA 2015 revision). It is one of the implementation systems of Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA). Three tools are used for the electronic monitoring of allergic diseases: a cell phone-based daily visual analogue scale (VAS) assessment of disease control, CARAT (Control of Allergic Rhinitis and Asthma Test) and e-Allergy screening (premedical system of early diagnosis of allergy and asthma based on online tools). These tools are combined with a clinical decision support system (CDSS) and are available in many languages. An e-CRF and an e-learning tool complete MASK. MASK is flexible and other tools can be add- ed. It appears to be an advanced, global and integrated ICT answer for many unmet needs in allergic diseases which will improve policies and standards. CITA: Allergy. 2015 Nov; 70(11):1372-92 DOI: 10.1111/all.12686 PMID: 26156419 TÍTULO: The Role of Epigenetics in the Progression of Non-Alcoholic Fatty Liver Disease AUTORES: Aguilar-Olivos NE, Oria-Hernández J, Ponciano-Rodríguez G, Chávez-Tapia NC, Uribe M, Méndez-Sánchez N. SUMMARY: Non-alcoholic fatty liver disease encompasses a spectrum of pathologies ranging from simple steatosis to non-alcoholic steatohepatitis. Patients with non-alcoholic steatohepatitis have increased risk of cirrhosis, liver failure and hepatocellular carcinoma. About 25% of subjects with simple steatosis progress to steatohepatitis; nowadays, the detailed pathological fac- tors influencing the progression of non-alcoholic fatty liver disease remains unclear. It is proposed that genetic and environmental factors interact to de- termine the disease phenotype. Epigenetics could explain some relationships 185

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 26162571 between genes and external influences. The epigenetic changes that have been related to non-alcoholic fatty liver disease are DNA methylation, one carbon metabolism, histone modifications and the presence of micro-RNA. DNA methylation and micro-RNAs have been investigated in human samples, whereas histone modification shave only been studied until now in animal and cellular models. The aim of this study is to review the most relevant informa- tion about epigenetic changes in non-alcoholic steatohepatitis. CITA: Mini Rev Med Chem. 2015; 15(14):1187-94 DOI: 10.2174/1389557515666150709115702 TÍTULO: International consensus on allergy immunotherapy AUTORES: Jutel M, Agache I, Bonini S, Burks AW, Calderon M, Canonica W, Cox L, Demoly P, Frew AJ, O'Hehir R, Kleine-Tebbe J, Muraro A, Lack G, Larenas D, Levin M, Nelson H, Pawankar R, Pfaar O, van Ree R, Sampson H, Santos AF, Du Toit G, Werfel T, Gerth van Wijk R, Zhang L, Akdis CA. ABSTRACT: Allergen immunotherapy (AIT) has been used to treat allergic disease since the early 1900s. Despite numerous clinical trials and me- ta-analyses proving AIT efficacious, it remains underused and is estimated to be used in less than 10% of patients with allergic rhinitis or asthma world- wide. In addition, there are large differences between regions, which are not only due to socioeconomic status. There is practically no controversy about the use of AIT in the treatment of allergic rhinitis and allergic asthma, but for atopic dermatitis or food allergy, the indications for AIT are not well defined. The elaboration of a wider consensus is of utmost importance because AIT is the only treatment that can change the course of allergic disease by pre- venting the development of asthma and new allergen sensitizations and by inducing allergen-specific immune tolerance. Safer and more effective AIT strategies are being continuously developed both through elaboration of new allergen preparations and adjuvants and alternate routes of administration. A number of guidelines, consensus documents, or both are available on both the international and national levels. The international community of allergy specialists recognizes the need to develop a comprehensive consensus re- port to harmonize, disseminate, and implement the best AIT practice. Conse- quently, the International Collaboration in Asthma, Allergy and Immunology, formed by the European Academy of Allergy and Clinical Immunology; the American Academy of Allergy, Asthma & Immunology; the American College of Allergy, Asthma & Immunology; and the World Allergy Organization, has decided to issue an international consensus on AIT. CITA: J Allergy Clin Immunol. 2015 Sep; 136(3):556-68 DOI: 10.1016/j.jaci.2015.04.047 PMID: 26166740 TÍTULO: Absorbable bioprosthesis for the treatment of bile duct injury in an experimental model AUTORES: Montalvo-Javé EE, Mendoza Barrera GE, Valderrama Treviño AI, Piña Barba MC, Montalvo-Arenas C, Rojas Mendoza F, León Mancilla B, García Pineda MA, Jaime Limón Á, Albores Saavedra J, Tapia-Jurado J. INTRODUCTION: Cholecystectomy is a common surgical procedure in which complications may occur, such as injury to the biliary tract, which are associated with high morbidity. The aim of this study was to demonstrate the 186

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR efficacy of a polymer-based absorbable bioprosthesis with bone scaffold for the treatment of bile duct injury in an animal model. MATERIALS AND METHODS: An absorbable bioprosthesis was used to re- place the common bile duct in 15 pigs which were divided into 3 groups with different follow-up sat 1, 3 and 6 months. The animals were anesthetized at these time points and laboratory tests, Magnetic Resonance Cholangiopan- creatogram [MRCP], Choledochoscopy using Spyglass and Endoscopic ret- rograde Cholangiopancreatogram [ERCP] were performed. After radiological evaluation was complete, the animals were euthanized and histological and immunohistochemical analyses were performed. RESULTS: Liver function tests at different time points demonstrated no sig- nificant changes. No mortality or postoperative complications were found in any of the experimental models. Imaging studies ([MRCP], [ERCP] and Cho- ledochoscopy with SpyGlass (™)) showed absence of stenosis or obstruc- tion in all the experimental models. DISCUSSION: Histological and immunohistochemical staining (CK19 and MUC5+) revealed the presence of biliary epithelium with intramural biliary glands in all the experimental models. There was no stenosis or obstruction in the bile duct. CONCLUSIONS: The bioprosthesis served as scaffolding for tissue regener- ation. There was no postoperative complication at 6 months follow-up. This bioprosthesis could be used to replace the bile duct in cancer or bile duct injury. The bioprosthesis may allow different modeling depending on the type of bile duct injury. CITA: Int J Surg. 2015 Aug; 20:163-9 DOI: 10.1016/j.ijsu.2015.06.074 PMID: 26167015 TÍTULO: Disappointing reliability of pulsatility indices to identify candidates for magnetic resonance imaging screening in population-based studies as- sessing prevalence of cerebral small vessel disease AUTORES: Del Brutto OH, Mera RM, Andrade Mde L, Castillo PR, Zam- brano M, Nader JA. BACKGROUND: Diagnosis of cerebral small vessel disease (SVD) is a challenge in remote areas where magnetic resonance imaging (MRI) is not available. Hospital-based studies in high-risk or stroke patients have found an association between the pulsatility index (PI) of intracranial arteries - as derived from transcranial Doppler (TCD) - and white matter hyperintensities (WMH) of presumed vascular origin. We aimed to assess the reliability of cerebral pulsatility indices to identify candidates for MRI screening in popula- tion-based studies assessing prevalence of SVD. METHODS: A representative sample of stroke-free Atahualpa residents aged ≥65years investigated with MRI underwent TCD. Using generalized linear models, we evaluated whether the PI of major intracranial arteries correlate with WMH (used as a proxy of diffuse SVD), after adjusting for demographics and cardiovascular risk factors. RESULTS: Out of 70 participants (mean age 70.6 ± 4.6 years, 57% women), 28 (40%) had moderate-to-severe WMH. In multivariate models, there were no differences across categories of WMH in the mean PI of middle cerebral 187

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR arteries (1.10 ± 0.16 vs. 1.22 ± 0.24, β: 0.065, 95% confidence interval (CI): -0.084-0.177, P = 0.474) or vertebra basilar arteries (1.11 ± 0.16 vs. 1.29 ± 0.27, β: 0.066, 95% CI:-0.0024-0.156, P = 0.146). CONCLUSIONS: Cerebral PI should not be used to identify candidates for MRI screening in population-based studies assessing the burden of SVD. CITA: J Neurosci Rural Pract. 2015 Jul-Sep; 6(3):336-8 DOI: 10.4103/0976-3147.158760 PMID: 26187275 TÍTULO: The interplay between hepatic stellate cells and hepatocytes in an in vitro model of NASH AUTORES: Barbero-Becerra VJ, Giraudi PJ, Chávez-Tapia NC, Uribe M, Tiribelli C, Rosso N. BACKGROUND & AIM: A complex interplay exists between hepatocytes and hepatic stellate cells (HSC) in hepatic fibrogenesis. The activation of HSCs after liver injury leads to production of extracellular matrix (ECM). Co-culture models could be useful to mimic the liver microenvironment. This study evaluates the effect of free fatty acids (FFA) on HSC cells and the in- terplay with hepatocytes via both soluble-mediator and cell-cell contact. METHODS: The human hepatocyte cell line (HuH7) and HSC cells (LX2) were exposed to FFA for 24 h in 3 different experimental set-ups: (A) mono- culture of HSC; (B) Transwell® system (effect of soluble mediators); and (C) Simultaneous Co-Culture (SCC) (cell-to-cell connections). Intracellular FFA accumulation was assessed qualitatively (microscopy) and quantitatively (flow cytometry); the activation of HSC (alpha smooth muscle actin, α-SMA) expression of ECM components were quantified by RT-PCR. RESULTS: FFA exposure induces intracellular fat accumulation in all the ex- perimental set-up but the expression of α-SMA was significantly increased only in SCC. On the contrary, the expression of ECM was substantially de- creased in the transwell® system. CONCLUSIONS: The HSC activation is independent of FFA accumulation but requires cell-to-cell interaction with hepatocyte. On the contrary, the gene regulation of ECM components seems to occur through paracrine me- diators. CITA: Toxicol In Vitro. 2015 Oct; 29(7):1753-8 DOI: 10.1016/j.tiv.2015.07.010 PMID: 26210614 TÍTULO: [Space medicine: Origins and current status in México] AUTORES: Carrillo Esper R. SUMMARY: Editorial CITA: Cir Cir. 2015 May-Jun; 83(3):181-2 DOI: 10.1016/j.circir.2015.06.034 188

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 26239169 TÍTULO: The dark story of the yellow rose: A case report of hepatotoxicity PMID: 26239325 associated with Cochlospermum vitifolium consumption as an herbal remedy AUTORES: Martínez-Rodriguez L, Murguía-Hernández K, García-Juárez I, Uribe-Esquivel M, Gómez-Reyes E. SUMMARY: Case report CITA: Rev Gastroenterol Mex. 2015 Jul-Sep; 80(3):220-2 DOI: 10.1016/j.rgmx.2015.02.003 TÍTULO: [Antihistamines for the treatment of urticaria in Mexico] AUTORES: Larenas-Linnemann D, Sánchez-Borges M, Del Río-Navarro BE, Alonzo-Romero Pareyón Mde L, Maldonado-García CA, et al. ABSTRACT: There are four types of histamine receptors. Allergic symp- toms, especially those in rhino conjunctivitis and urticaria, are mainly caused by activation of histamine receptor 1 (H1). Consequently, oral H1-antihis- tamines form and integral part of the treatment of these diseases. Antihis- tamines are inverse agonists that stabilize the non-active configuration of the histamine receptor. First generation H1-antihistamines cause a variety of adverse effects via several mechanisms: sedation (accumulation in the central nervous system), dry mouth, urinary retention, weight gain (low se- lectivity: stimulation of serotonin/muscarinic/alpha-adrenergic receptors) and drug interactions (substrate of CYP450-3A4). Generally second generation H1-antihistamines have a better safety profile. New guidelines on allergic rhinitis and urticaria recommend second generation H1-antihistamines as first line drugs, with -if necessary-four-times up dosing to obtain control in urticaria. The enhanced efficacy of quadruple doses in urticaria, while main- taining a good safety profile, has been shown for bilastine, desloratadine and levocetirizine (rupatadine). For ebastine and fexofenadine only the safety of quadruple doses has been shown till now. Extreme precaution should be taken with astemizol and terfenadine that never should be up-dosed, as high serum concentrations can cause potentially fatal ventricular tachycardia. First generation antihistamines are not recommended as first line treatment and up dosing is not safe. CITA: Rev Alerg Mex. 2015 Jul-Sep; 62(3):157-74 PMID: 26256891 TÍTULO: Granulocyte-colony stimulating factor for acute-on-chronic liver fail- ure: systematic review and meta-analysis AUTORES: Chavez-Tapia NC, Mendiola-Pastrana I, Ornelas-Arroyo VJ, Noreña-Herrera C, Vidaña-Perez D, Delgado-Sanchez G, Uribe M, Barrien- tos-Gutierrez T. SUMMARY: Acute-on-chronic liver failure (ACLF) is associated with in- creased short and long-term mortality. Animal models of liver failure have demonstrated that granulocyte-colony stimulating factor (G-CSF) acceler- ates the liver regeneration process and improves survival. However, clini- cal evidence regarding the use of G-CSF in ACLF remains scarce. The aim of this study was to assess the benefits and harms of G-CSF in patients with acute-on-chronic liver failure. An electronic search was made in The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EM- 189

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR BASE and LILACS up to November 2013. Randomized clinical trials com- paring the use of any regimen of G-CSF against placebo or no intervention in patients with ACLF were included. Primary outcomes included overall mortality, mortality due multi-organ failure, and adverse events. Relative risk (RR) and mean difference (MD) were used. Two trials involving 102 pa- tients were included. A significant reduction in short-term overall mortality was observed in patients receiving G-CSF compared to controls (RR 0.56; 95%CI 0.39, 0.80). G-CSF failed to reduce mortality secondary to gastro- intestinal bleeding (RR 1.45; 95%CI 0.50, 4.27). Adverse effects reported included: fever, rash, herpes zoster, headache and nausea. In conclusion, the use of G-CSF for the treatment of patients with ACLF significantly re- duced short-term mortality. While the evidence is still limited, the apparent benefit observed on short-term mortality, mild adverse effects and lack of an alternative therapy make the use of G-CSF in ACLF patients a reasonable alternative when liver transplantation is contraindicated or unavailable. CITA: Ann Hepatol. 2015 Sep-Oct; 14(5):631-41 DOI: 10.1016/S1665-2681(19)30757-4 PMID: 26256895 TÍTULO: SFRP5 hepatic expression is associated with non-alcoholic liver disease in morbidly obese women AUTORES: Gutiérrez-Vidal R, Vega-Badillo J, Reyes-Fermín LM, Hernán- dez-Pérez HA, Sánchez-Muñoz F, López-Álvarez GS, Larrieta-Carrasco E, Fernández-Silva I, Méndez-Sánchez N, Tovar AR, Villamil-Ramírez H, Me- jía-Domínguez AM, Villarreal-Molina T, Hernández-Pando R, Campos-Pérez F, Aguilar-Salinas CA, Canizales-Quinteros S. BACKGROUND AND AIMS: Secreted frizzled-related protein 5 (SFRP5) was recently described as a new adipokine protective for hepatic steato- sis and other obesity-related complications in the mouse model. To date, SFRP5 expression in non-alcoholic fatty liver disease (NAFLD) has not been fully assessed in humans. We measured circulating SFRP5 levels and its expression in liver and adipose tissue, and evaluated its association with NAFLD in morbidly obese women. MATERIAL AND METHODS: Fifty-four morbidly obese women undergoing bariatric surgery were included in the study. Liver biopsies were used for histology and hepatic triglyceride content quantification. Circulating SFRP5 levels were measured through enzyme-linked immune absorbent assay, and SFRP5 expression was performed in hepatic and adipose tissue (subcutane- ous and visceral). RESULTS: Although circulating SFRP5 levels showed a tendency to de- crease with NAFLD progression, no significant differences were observed among non-alcoholic steatosis, steatohepatitis, and control subjects. Hepat- ic SFRP5 expression showed a negative correlation with hepatic triglyceride content (r = -0.349, P = 0.016for mRNA and r = -0.291, P = 0.040 for SRFP5 protein) and ALT serum levels (r =-0.437, P = 0.001 for SRFP5 protein). In addition, hepatic SFRP5 protein levels were significantly lower in NASH than in control subjects (P = 0.006). CONCLUSION: This is the first study reporting an association of hepatic SFRP5expression with NAFLD in humans. CITA: Ann Hepatol. 2015 Sep-Oct; 14(5):666-74 DOI: 10.1016/S1665-2681(19)30761-6 190

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 26290033 TÍTULO: [Elena de Cespedes: The eventful life of a XVI century surgeon] AUTORES: Carrillo Esper R, Carrillo Córdova JR, Carrillo Córdova LD, Carrillo Córdova DM, Carrillo Córdova CA. SUMMARY: Throughout the history of surgery there have been exceptional cases of surgeons around the world. One of them is Elena/o of Cespedes. Born as a girl, this hermaphrodite dedicated all his life to acting as a man, do- ing jobs that were only for men such as a soldier, peasant, and surgeon. She was the first licensed surgeon in Spain and maybe in all Europe. She married a woman and then was tried for sodomy by the Spanish Inquisition command- ed by inquisitor Lope de Mendoza. She was founded guilty and punished with 200 lashes and a 10-year service at a hospital, dressed as a woman. CITA: Gac Med Mex. 2015 Jul-Aug; 151(4):538-42 PMID: 26290034 TÍTULO: [Andres Vesalio, Francisco Díaz, Miguel de Cervantes Saavedra and the birth of urology in the 16th Century] AUTORES: Carrillo Esper R, Carrillo Córdova LD, Carrillo Córdova DM, Carrillo Córdova CA, Carrillo Córdova JR. SUMMARY: In the sixteenth century there were great advances in science, literature, and the arts. During this century, urology as a specialty was con- ceived, thanks to the contributions of Andreas Vesalius, anatomist and lead- ing physician to the court of Charles V, and Dr. Francisco Diaz, a native of Alcala de Henares, surgeon and clinician. Dr. Diaz had a close relationship with Miguel de Cervantes, who at one point in his life suffered from renal colic. In his masterpiece \"Re-Printed Treaty of all diseases of the kidneys, bladder and wattles of the Cock and Urina, divided into three books,\" of which the first book of urology is the History of Medicine, describes in detail the clinical and therapeutic aspects of urological diseases, known as the \"bad stone\" and urethral strictures known as \"wattles\", in addition to describing the different surgical techniques and the development of new instruments for urological procedures, which include the cisorio instrument and the Speculum pudendi. For the above, Dr.Francisco Diaz is considered the father of urology. CITA: Gac Med Mex. 2015 Jul-Aug; 151(4):543-52 PMID: 26320096 TÍTULO: Sigmoidectomy with primary anastomosis for complicated diverticulitis AUTORES: Reyes-Espejel L, Ruiz-Campos M, Correa-Rovelo JM, García-Osogobio S. BACKGROUND: It is possible to resect the perforated segment and rees- tablish intestinal continuity with adequate morbidity and mortality results in patients with complicated diverticulitis. AIMS: To evaluate the type of surgery performed at our center and the re- sults of the procedures in patients with complicated diverticulitis. MATERIAL AND METHODS: All patients that underwent sigmoidectomy due to complicated diverticulitis within the time frame of 2005-2012 were included in the study. The primary objective was to evaluate the type of sur- gery performed. 191

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR The secondary objective was to evaluate patient morbidity and mortality after 30 postoperative days. RESULTS: The study included 77 patients with a mean age of 51.17±12.80 years. The majority of the patients were men (64.9%) (n=50) and the mean BMI was28.24±4.06kg/m2. A total of 63.6% (n=49) patients presented with a Hinchey iii-iv classification. Sigmoidectomy with primary anastomosis was performed in 58.4 % (n=45) of the patients, 48.8% (22/45) of whom present- ed with Hinchey III-IV. Primary anastomosis was more frequently performed in patients that had Hinchey I-II (P=.001). Open surgery was carried out in 85.7% (n=66) of the cases. The mean surgery duration was longer in the patients with primary anastomosis (181.73±68.2min vs. 152.13±65.8min) (P>.05). Colorectal surgeons performed the procedures in 44.2% (n=34) of the cases. Complications presented in 23.4% (n=18) of the patients and there was a tendency toward more complications in patients that underwent the Hartmann's procedure. The mortality rate was 2.6% (n=2). CONCLUSIONS: Sigmoidectomy with primary anastomosis is a frequent sur- gery in patients with complicated diverticulitis at our hospital. There was no dif- ference in morbidity and mortality, compared with the Hartmann's procedure. CITA: Rev Gastroenterol Mex. 2015 Oct-Dec; 80(4):255-9 DOI: 10.1016/j.rgmx.2015.07.005 PMID: 26339640 TÍTULO: The Role of Dendritic Cells in Fibrosis Progression in Nonalcoholic Fatty Liver Disease AUTORES: Almeda-Valdes P, Aguilar Olivos NE, Barranco-Fragoso B, Uribe M, Méndez-Sánchez N. SUMMARY: Nonalcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver disease. NAFLD encompasses a wide range of pathol- ogies, from simple steatosis to steatosis with inflammation to fibrosis. The pathogenesis of NAFLD progression has not been completely elucidated, and different liver cells could be implicated. This review focuses on the cur- rent evidence of the role of liver dendritic cells (DCs) in the progression from NAFLD to fibrosis. Liver DCs are a heterogeneous population of hepatic antigen-presenting cells; their main function is to induce T-cell mediated im- munity by antigen processing and presentation to T cells. During the steady state liver DCs are immature and tolerogenic. However, in an environment of chronic inflammation, DCs are transformed to potent inducers of immune re- sponses. There is evidence about the role of DC in liver fibrosis, but it is not clearly understood. Interestingly, there might be a link between lipid metabo- lism and DC function, suggesting that immunogenic DCs are associated with liver lipid storage, representing a possible pathophysiological mechanism in NAFLD development. A better understanding of the interaction between inflammatory pathways and the different cell types and the effect on the pro- gression of NAFLD is of great relevance. CITA: Biomed Res Int. 2015; 2015:768071 DOI: 10.1155/2015/768071 PMID: 26386520 TÍTULO: Phosphaturic mesenchymal tumors. Survey of 8 cases from a sin- gle Mexican medical institution AUTORES: Angeles-Angeles A, Reza-Albarrán A, Chable-Montero F, Cor- dova-Ramón JC, Albores-Saavedra J, Martinez-Benitez B. 192

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 26417398 SUMMARY: Phosphaturic mesenchymal tumor (PMT) is a morphologically PMID: 26420374 heterogeneous soft tissue and bone neoplasm, producing a paraneoplas- tic syndrome due to phosphate wasting. These tumors produce fibroblast growth factor 23, which is implicated in renal tubule phosphate loss. Medical records of patients seen from 1999 to 2013with osteomalacia associated or not with a tumor were reviewed. Clinical and laboratory data, radiographic studies, and follow-up of 8 patients were tabulated. Histologic features and the immunoprofile of the tumors were analyzed. There were 208 patients with osteomalacia, but only 8 (3.84%) had osteomalacia associated with a tumor. The median age of the patients was 40 years. The tumor size ranged from 1.5 to 4 cm. Five were located in soft tissues and skin; and 3, in bones. Osteomalacia symptoms lasted from 2 to 14 years with a median of 6years. Laboratory data showed hypophosphatemia and phosphaturia in all patients. All tumors were histologically benign. Histologically, the salient features were a hemangiopericytoid pattern, chronic hemorrhage, and microcystic areas. All neoplasms were diffusely positive for vimentin and focally positive for epithelial membrane antigen, CD34, and S-100 protein. Ki-67 was posi- tive in approximately 10% of neoplastic cells in 2 cases and less than 1% in the remainder. We report 8 cases of PMTs producing osteomalacia, from a single third-level Mexican medical institution. These tumors occurred in soft tissues, skin, and bones. All tumors were benign, small, not easily detected by physical examination and diagnosed due to the metabolic abnormalities. CITA: Ann Diagn Pathol. 2015 Dec; 19(6):375-80 DOI: 10.1016/j.anndiagpath.2015.08.003 TÍTULO: Allergen immunotherapy on the way to product-based evaluation-a WAO statement AUTORES: Bachert C, Larché M, Bonini S, Canonica GW, Kündig T, Lare- nas-Linnemann D, Ledford D, Neffen H, Pawankar R, Passalacqua G. ABSTRACT: Allergen immunotherapy (AIT) is widely used in clinical practice for patients with moderate to severe allergic rhinitis due to inhalant allergens and may be delivered via subcutaneous (SCIT) and sublingual routes (SLIT). However, the quality of evidence for individual AIT products is very heteroge- neous, and extensions of overall conclusions (\"class effects\") on the efficacy and disease-modifying effects to all AIT products are unjustified. In contrast, each product needs to be evaluated individually, based on available study results, to justify efficacy and specific claims on sustained and disease mod- ifying effects per allergen and targeted patient group (children vs. adults, al- lergic rhinitis vs. asthma). WAO intends to support the current development to evidence-based AIT, which ultimately will lead to a more efficacious treat- ment of allergic patients and the appropriate recognition of AIT. CITA: World Allergy Organ J. 2015 Sep 16; 8(1):29 DOI: 10.1186/s40413-015-0078-8 TÍTULO: The association of sleep-disordered breathing with high cerebral pulsatility might not be related to diffuse small vessel disease. A pilot study AUTORES: Castillo PR, Del Brutto OH, Andrade Mde L, Zambrano M, Na- der JA. BACKGROUND: In a population-based sampling study conducted in com- munity-dwelling older adults living in rural Ecuador, we aimed to assess the 193

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 26427522 relation among sleep-disordered breathing, cerebral pulsatility index, and diffuse small vessel disease. METHODS: Of 25 participants, 9 (36%) had moderate-to-severe sleep-dis- ordered breathing, characterized by an apnea/hypopnea index ≥15 per hour, and 10 (40%) had moderate-to-severe white matter hyper intensities, graded according to the modified Fazekas scale. Mean (SD) pulsatility index in the middle cerebral artery was 1.18 (0.19) and positively correlated with the ap- nea/hypopnea index (R =.445, P = .03, [Pearson's correlation coefficient]). The middle cerebral artery pulsatility index was increased in persons with moderate-to-severe sleep-disordered breathing compared with persons who had none-to-mild sleep-disordered breathing (mean [SD] 1.11 [0.12] vs. 1.3 [0.23], P = .01). No significant differences were found in the preva- lence of moderate-to-severe white matter hyper intensities across groups of sleep-disordered breathing (P = .40) or in the mean apnea/hypopnea index across groups of persons with none-to-mild or moderate-to-severe white matter hyper intensities (P = .16). CONCLUSIONS: This pilot study shows that moderate-to-severe sleep-dis- ordered breathing correlates with cerebral pulsatility, but such association might be independent of diffuse small vessel disease. CITA: BMC Res Notes. 2015 Sep 29; 8:500 DOI: 10.1186/s13104-015-1481-5 TÍTULO: Pharmacogenomics in the treatment of lung cancer: an update AUTORES: Morales-Espinosa D, García-Román S, Karachaliou N, Rosell R. SUMMARY: Significant advances have been made in the analysis of the human genome in thefirst decades of the 21st century and understanding of tumor biology has matured greatly. The identification of tumor-associated mu- tations and the pathways involved has led to the development of targeted anti- cancer therapies. However, the challenge now in using chemotherapy to treat non small-cell lung cancer is to identify more molecular markers predictive of drug sensitivity and determine the optimal drug sequences in order to tailor treatment to each patient. This approach could permit selection of patients who could benefit most from a specific type of chemotherapy by matching their tumor and individual genetic profile. Nevertheless, this potential has been lim- ited so far by reliance on the single biomarker approach, though this is now on the way to being overcome through whole genome studies. CITA: Pharmacogenomics. 2015; 16(15):1751-60 DOI: 10.2217/pgs.15.99 PMID: 26436348 TÍTULO: Pearls for optimizing biomedical manuscripts AUTORES: Tabibian JH, Aguilar-Olivos NE, Méndez-Sánchez N. SUMMARY: Editorial CITA: Ann Hepatol. 2015 Nov-Dec; 14(6):774-6 DOI: 10.5604/16652681.1171742 194

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 26436352 TÍTULO: Prevalence of hepatitis C virus infection among patients undergo- ing haemodialysis in Latin America PMID: 26481977 AUTORES: Gómez-Gutiérrez C, Chávez-Tapia NC, Ponciano-Rodríguez PMID: 26485098 G, Uribe M, Méndez-Sánchez N. SUMMARY: Hepatitis C infection is a worldwide problem. The global preva- lence of the hepatitis C virus (HCV) averages 3%. Moreover, its prevalence among patients undergoing haemodialysis (HD) varies worldwide, ranging from as low as 1% to up to 70%. There are few data on its prevalence in developing countries, and evenless information is available on HD patients. A literature review revealed that the prevalence of HCV infection among pa- tients undergoing HD in Latin America ranges from 4.2 to 83.9%, with most data stemming from Argentina, Brazil, Mexico, Peru, Chile, Venezuela and Cuba. The most common genotype was genotype 1, and subtype 1b was the most frequent. The risk factors associated with this condition were the dura- tion of the HD treatment and blood transfusion before hepatitis C screening. In addition, HCV RNA detection by polymerase chain reaction is crucial for the diagnosis of HCV infection in HD patients. Trials using combinations of new oral antiviral drugs, such as sofosbuvir and combo (ombitasvir, parita- previr, ritonavir and dasabuvir), should be the next step in the improvement of care among HD patients with HCV, because these therapeutic agents ap- parently do not require dose adjustment according to renal function. Finally, information on this subgroup of patients remains unavailable in some coun- tries; therefore, additional studies are needed to determine the prevalence trend of HCV infection in these populations. CITA: Ann Hepatol. 2015 Nov-Dec; 14(6):807-14 DOI: 10.5604/16652681.1171751 TÍTULO: Clinical Image In Gastroenterology: Disseminated gastrointestinal strongyloidiasis AUTORES: Antolinez-Motta JM, Chablé-Montero F, Torre A. SUMMARY: Case report CITA: Rev Gastroenterol Mex. 2015 Oct-Dec; 80(4):280-1 DOI: 10.1016/j.rgmx.2015.05.006 TÍTULO: Patient selection for subcutaneous versus sublingual inmunotherapy AUTORES: Larenas-Linnemann D. PURPOSE OF REVIEW: With the Food and Drug Administration's approv- al of sublingual allergen-specific immunotherapy (SL-AIT) tablets for grass and ragweed pollen, SL-AIT is progressively gathering importance not only in Europe, but also in the United States and other parts of the world. We reviewed issues related to the selection of patients for the sublingual or the subcutaneous route for allergic patients, based on what has been published since January 2014 on subcutaneous-versus-SL-AIT efficacy, safety and other issues. (Figure is included in full-text article) RECENT FINDINGS: As patient's adherence seems one of the major prob- lems in real-life AIT, investigators have sought how to enhance AIT simplicity by changing the route to home-administrated SL-AIT, and by shortening the 195

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 26485100 subcutaneous-allergen-specific immunotherapy (SC-AIT) build-up or mainte- PMID: 26559377 nance phase. The latter was safe with several hypoallergenic extracts. As for SL-AIT, double blind placebo-controlled large trials in patients with allergic rhinitis and asthma have shown the efficacy and safety of ragweed pollen and house dustmite SLIT tablets and highly concentrated liquid formulations, primarily in adults. A large trial with SLIT in 3-year-old children was effective. SUMMARY: With the improvement of SL-AIT efficacy, the selection of SC- versus-SL-AIT will probably increasingly be based not on efficacy, but on practical aspects, without losing sight of which SL-AIT products have proven efficacy. CITA: Curr Opin Allergy Clin Immunol. 2015 Dec; 15(6):588-95 DOI: 10.1097/ACI.0000000000000219 TÍTULO: Allergen immunotherapy: an update on protocols of administration AUTORES: Larenas-Linnemann D. PURPOSE OF REVIEW: Allergen immunotherapy (AIT) is still the only caus- al treatment for allergic rhinitis and asthma. However, conventional subcuta- neous AIT administration schedules are time-consuming and safety issues still play a role; for sublingual AIT, the best efficacy is still investigated and for food allergy the best efficacy-safety balance is not yet completely dis- covered. Investigators have made progress in these fields lately. (Figure is included in full-text article.) RECENT FINDINGS: Since January 2014, several (ultra) rush or cluster build-up phases with hypoallergic variants of extracts have been explored with success. Also, the efficacy of only pre seasonal subcutaneous AIT was demonstrated for tree and grass pollen. Sublingual AIT was shown to be effective and well tolerated in allergic rhinitis and asthma with tablets and with highly concentrated liquid formulations (ragweed, house dust mite), but not cockroach. For food allergy, oral immunotherapy is promising, but close attention should be paid to the exact administration schedule, maintenance dose, and the definition of efficacy (desensitization or real tolerance, as de- fined by a negative challenge test at least 4 months off treatment). SUMMARY: The practicing physician should be watchful for advances in the field of aeroallergen AIT and food oral immunotherapy, analyzing the pre- sented information in detail and interpreting conclusions product specifically, without generalizing. CITA: Curr Opin Allergy Clin Immunol. 2015 Dec; 15(6):556-67 DOI: 10.1097/ACI.0000000000000220 TÍTULO: A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pan- creas AUTORES: Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offer- haus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T 196

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 26567277 SUMMARY: International experts met to discuss recent advances and to PMID: 26567877 revise the 2004recommendations for assessing and reporting precursor le- sions to invasive carcinomas of the pancreas, including pancreatic intraep- ithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), mucinous cystic neoplasm, and other lesions. Consensus recommendations include the following: (1) To improve concordance and to align with prac- tical consequences, a 2-tieredsystem (low vs. high grade) is proposed for all precursor lesions, with the provision that the current PanIN-2 and neo- plasms with intermediate-grade dysplasia now be categorized as low grade. Thus, \"high-grade dysplasia\" is to be reserved for only the uppermost end of the spectrum (\"carcinoma in situ\"-typelesions). (2) Current data indicate that PanIN of any grade at a margin of are sected pancreas with invasive carcinoma does not have prognostic implications; the clinical significance of dysplasia at a margin in a resected pancreas with IPMN lacking invasive carcinoma remains to be determined. (3) Intraductal lesions0.5 to 1 cm can be either large PanINs or small IPMNs. The term \"incipient IPMN\" should be reserved for lesions in this size with intestinal or oncocytic papillaeor GNAS mutations. (4) Measurement of the distance between an IPMN and invasive carcinoma and sampling of intervening tissue are recommended to assess concomitant versus associated status. Conceptually, concomitant invasive carcinoma (in contrast with the \"associated\" group) ought to be genetically distinct from an IPMN elsewhere in the gland. (5) \"Intraductal spread of in- vasive carcinoma\" (aka, \"colonization\") is recommended to describe lesions of invasive carcinoma invading back into and extending along the ductal system, which may morphologically mimic high-grade PanIN or even IPMN. (6) \"Simple mucinous cyst\"is recommended to describe cysts >1 cm having gastric-type flat mucinous liningat most minimal atypia without ovarian-type stroma to distinguish them from IPMN. (7) Human lesions resembling the ac- inar to ductal metaplasia and atypical flat lesions of genetically engineered mouse models exist and may reflect an alternate pathway of carcinogenesis; however, their biological significance requires further study. These revised recommendations are expected to improve our management and under- standing of precursor lesions in the pancreas. CITA: Am J Surg Pathol. 2015 Dec; 39(12):1730-41 DOI: 10.1097/PAS.0000000000000533 TÍTULO: Echinocandins: The Expanding Antifungal Armamentarium AUTORES: Aguilar-Zapata D, Petraitiene R, Petraitis V. SUMMARY: The echinocandins are large lipopeptide molecules that, since their discovery approximately 41 years ago, have emerged as important additions to the expanding armamentarium against invasive fungal diseas- es. Echinocandins exert in vitro and in vivo fungicidal action against most Candida species and fungistatic action against Aspergillus species. However, the population of patients at risk for developing invasive fungal infections continues to increase. New therapeutic strategies using echinocandins are needed to improve clinical outcomes inpatients with invasive fungal disease. CITA: Clin Infect Dis. 2015 Dec 1; 61 Suppl 6:S604-11 DOI: 10.1093/cid/civ814 TÍTULO: Gastrocolic fistula secondary to adenocarcinoma of the transverse colon: a case report AUTORES: Vergara-Fernández O, Gutiérrez-Grobe Y, Lavenant-Borja M, Rojas C, Méndez-Sánchez N. 197

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 26644826 INTRODUCTION: Gastrocolic fistula is a rare complication of adenocarci- noma of the colon. Despite radical resections, these patients usually have a poor prognosis with a mean survival of 23 months and long-term survival is rarely reported. CASE PRESENTATION: A 48-year-old Latino-American man presented with watery diarrhea, diffuse abdominal pain and weight loss for 3 months. A computed tomography scan revealed a mass in the splenic flexure that had infiltrated his stomach and diaphragm. Panendoscopy and colonoscopy con- firmed the presence of a fistula between the distal transverse colon and the stomach, which was secondary to a colon cancer. His colon, stomach and left diaphragm were resected en bloc. A histological examination revealed a moderately differentiated adenocarcinoma of the colon that had infiltrated the full width of the gastric wall with 37negative lymph nodes and clear sur- gical margins. Adjuvant chemotherapy with capecitabine and oxaliplatin was administered after surgery. Our patient is alive and without any recurrence 5 years after surgery. CONCLUSIONS: En bloc resection with adjuvant chemotherapy offers the best treatment option for gastrocolic fistulas. This is one of the patients with greater survival reported in the medical literature. CITA: J Med Case Rep. 2015 Oct 27; 9:263 DOI: 10.1186/s13256-015-0725-2 TÍTULO: Partial correlation analyses of global diffusion tensor imaging-de- rived metrics in glioblastoma multiforme: Pilot study AUTORES: Cortez-Conradis D, Rios C, Moreno-Jimenez S, Roldan-Va- ladez E. AIM: To determine existing correlates among diffusion tensor imaging (DTI)-derived metrics in healthy brains and brains with glioblastoma multi- forme (GBM). METHODS: Case-control study using DTI data from brain magnetic reso- nance imaging of 34 controls (mean, 41.47; SD, ± 21.94 years; range, 21-80 years) and 27patients with GBM (mean, SD; 48.41 ± 15.18 years; range, 18-78 years). Image post processing using FSL software calculated eleven tensor metrics: fractional (FA) and relative anisotropy; pure isotropic (p) and anisotropic diffusions (q), total magnitude of diffusion (L); linear (Cl), planar (Cp) and spherical tensors (Cs); mean (MD), axial (AD) and radial diffusivi- ties (RD). Partial correlation analyses (controlling the effect of age and gen- der) and multivariate Mancova were performed. RESULTS: There was a normal distribution for all metrics. Comparing healthy brains vs brains with GBM, there were significant very strong bivar- iate correlations only depicted in GBM: [FA↔Cl (+)], [FA↔q (+)], [p↔AD (+)], [AD↔MD (+)], and [MD↔RD (+)]. Among 56 pairs of bivariate correla- tions, only seven were significantly different. The diagnosis variable depicted a main effect [F-value (11, 23) = 11.842, P ≤ 0.001], with partial eta squared = 0.850, meaning a large effect size; age showed a similar result. The age also had a significant influence as a covariate [F (11, 23) = 10.523, P < 0.001], with a large effect size (partial eta squared = 0.834). CONCLUSION: DTI-derived metrics depict significant differences be- tween healthy brains and brains with GBM, with specific magnitudes and 198

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 27186998 correlations. This study provides reference data and makes a contribu- tion to decrease the underlying empiricism in the use of DTI parameters 2016 in brain imaging. CITA: World J Radiol. 2015 Nov 28; 7(11):405-14 DOI: 10.4329/wjr.v7.i11.405 TÍTULO: [Minimal invasive anterolateral ankle stabilization with a modified Hemi-Castaing technique] AUTORES: Cuéllar-Avaroma A, Jambou S, De Lavigne C, Guillo S, King- Martínez AC. BACKGROUND: The lesions to the lateral ligaments of the ankle are a com- mon sports related injury. There are multiple surgical technics to address the problem all with a common goal: achieve a proper stability of the ankle. The improvements in the minimal invasive technics as well as those in the materials to fixate bone-tissue have also impacted the technics for lateral stabilization of the ankle. MATERIAL AND METHODS: We included all the patients with a diagnosis of lateral ankle instability which underwent surgery with a modify Hemi-Casting procedure with minimal invasive approach during the period between May 2004 and December 2007. We have an average follow-up of 30.3 months. RESULTS: Our patients presented a good outcome with an improvement in the Karlsson’s scale of 48.7 points (± 15.6) in the preoperative to 93.6 points (±9.6) during follow-up. They returned to their sports activities after an aver- age of 5.72 months (± 4.93). We used dynamic X-ray’s taken with the Telos system and achieved 81.9% of our patients presented an excellent and good personal satisfaction. CONCLUSIONS: The modifications to the Hemi-Castaing procedure to per- form it with a minimal invasive technic are reproducible and provide us with another tool for the treatment of this pathology specially in the cases where there is no sufficient tissue to perform an anatomical repair. CITA: Acta Ortop Mex. 2015 Jul-Aug; 29(4):212-7 PMID: 26178311 TÍTULO: Temporal bone thickness and texture are major determinants of the high rate of insonation failures of transcranial Doppler in Amerindians (the Atahualpa Project) AUTORES: Del Brutto OH, Mera RM, de la Luz Andrade M, Espinosa V, Castillo PR, Zambrano M, Nader JA. PURPOSE: To assess the role of temporal bone characteristics in transcra- nial Doppler (TCD) insonation failures in Amerindians living in rural Ecuador. METHODS: We evaluated thickness and texture of temporal bones in com- munity-dwelling Amerindians ≥65 years old undergoing TCD. Using receiver operator characteristics curve analysis and generalized estimating equa- tions, we investigated factors associated with insonation failures. 199

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR RESULTS: Of 65 participants (mean age 74.7 ± 6.7 years, 60% women), 32 (49%) had uni- or bilateral insonation failure through temporal windows. Considering temporal bones independently, 57 of 130 (44%) had poor inson- ation. Mean thickness was higher (4.7 ± 1.2 versus 2.7 ± 0.9, p < 0.0001), and texture more often heterogeneous (93% versus 22%, p < 0.0001) in bones with poor acoustic windows. Thickness, better predicting poor inson- ation, was ≥3.6 mm if used alone, and ≥2.7mm if used together with hetero- geneous texture. For every millimeter of increase in thickness, subjects were 2.9 times more likely to have insonation failures. Per se, heterogeneous tex- ture increased by 3.2 times the odds for poor insonation. In all models, being woman increased the odds for poor insonation by six to nine times. CONCLUSIONS: Temporal bone thickness and texture are independent pre- dictors of TCD insonation failure in Amerindians. CITA: J Clin Ultrasound. 2016 Jan; 44(1):55-60 DOI: 10.1002/jcu.22284 PMID: 26385081 TÍTULO: Interrupted Aortic Arch in an Adult and Myocardial Infarction AUTORES: Mendoza Díaz PM, Herrera Gomar M, Rojano Castillo J. SUMMARY: Case report CITA: Rev Esp Cardiol (Engl Ed). 2016 Feb; 69(2):212 DOI: 10.1016/j.rec.2015.06.019 PMID: 26435078 TÍTULO: The role of bariatric surgery in the management of nonalcoholic fatty liver disease and metabolic syndrome AUTORES: Aguilar-Olivos NE, Almeda-Valdes P, Aguilar-Salinas CA, Uri- be M, Méndez-Sánchez N. SUMMARY: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD is strongly associated with obesity and metabolic syndrome (MetS). Current treatment of NAFLD is based on weight reduction. Bariatric surgery is the most effective treatment for morbid obesity and its associated metabolic comorbidities. There is evi- dence indicating that bariatric surgery improves histological and biochemical parameters of NAFLD, but currently is not considered a treatment option for NAFLD. The aim of this work is to review the evidence for the effects of bariatric surgery on NAFLD and the MetS. We found that insulin resistance, alterations in glucose metabolism, hypertension, plasma lipids, transaminas- es, liver steatosis, steatohepatitis and fibrosis improve after bariatric sur- gery. Weight loss and improvement of NAFLD are greater after RYGB than after other interventions. These findings were obtained from retrospective or cohort studies. There are no studies designed to evaluate liver-specific mortality, liver transplantation, or quality of life. Patients with indications for bariatric surgery will benefit from the improvements in the MetS and NAFLD. CITA: Metabolism. 2016 Aug; 65(8):1196-207 DOI: 10.1016/j.metabol.2015.09.004 200