RESUMEN INVESTIGADORES-2

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR their sports activities at an average of 4.6 (± 1.27) months. Our patients rat- ed their personal satisfaction as very satisfied in 16cases (66.7%), satisfied in seven cases (29.2%), regular satisfaction in one case (4.2%). One patient developed a complex regional pain syndrome that was resolved with physi- cal therapy and another had a wound erythema. CONCLUSION: The posterior ankle impingement is a pathology which di- agnosis is mainly clinical, it is greatly associated with an os trigonum or a large Stieda process. It has a strong repercussion in the sports activities of the patients. The arthroscopic treatment is an ideal option for this pathology as it presents a good postoperative recovery with a swift return to patients preoperative sports activities. CITA: Acta Ortop Mex. 2017 Jan-Feb; 31(1):24-29 PMID: 28767003 TÍTULO: The Right to Live with Dignity and the Right to Die with Dignity PMID: 28794855 AUTORES: Ñamendys-Silva SA. SUMMARY: Letter to the editor CITA: J Palliat Med. 2017 Nov; 20(11):1186 DOI: 10.1089/jpm.2017.0316 TÍTULO: Allergen immunotherapy for allergic rhinoconjunctivitis: a systemat- ic overview of systematic reviews AUTORES: Nurmatov U, Dhami S, Arasi S, Roberts G, Pfaar O, Muraro A, Ansotegui IJ, Calderon M, Cingi C, Durham S, van Wijk RG, Halken S, Hamelmann E, Hellings P, Jacobsen L, Knol E, Larenas-Linnemann D, Lin SY, Maggina V, Oude-Elberink H, Pajno G, Panwankar R, Pastorello E, Pit- sios C, Rotiroti G, Timmermans F, Tsilochristou O, Varga EM, Wilkinson J, Williams A, Worm M, Zhang L, Sheikh A. BACKGROUND: The European Academy of Allergy and Clinical Immunol- ogy (EAACI) is developing Guidelines on Allergen Immunotherapy (AIT) for Allergic Rhino conjunctivitis (ARC). To inform the development of recommen- dations, we sought to critically assess the systematic review evidence on the effectiveness, safety and cost-effectiveness of AIT for ARC. METHODS: We undertook a systematic overview, which involved searching nine international biomedical databases from inception to October 31, 2015. Studies were independently screened by two reviewers against pre-defined eligibility criteria and critically appraised using the Critical Appraisal Skills Programme (CASP) Systematic Review Checklist for systematic reviews. Data were descriptively synthesized. RESULTS: Our searches yielded a total of 5932 potentially eligible studies, from which 17 systematic reviews met our inclusion criteria. Eight of these were judged to be of high, five moderate and three low quality. These re- views suggested that, in carefully selected patients, subcutaneous (SCIT) and sublingual (SLIT) immunotherapy resulted in significant reductions in symptom scores and medication requirements. Serious adverse outcomes were rare for both SCIT and SLIT. Two systematic reviews reported some evidence of potential cost savings associated with use of SCIT and SLIT. 251

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR CONCLUSIONS: We found moderate-to-strong evidence that SCIT and SLIT can, inappropriately selected patients, reduce symptoms and medica- tion requirements in patients with ARC with reassuring safety data. This ev- idence does however need to be interpreted with caution, particularly given the heterogeneity in the populations, allergens and protocols studied. There is a lack of data on the relative effectiveness, cost-effectiveness and safe- ty of SCIT and SLIT. We are now systematically reviewing all the primary studies, including recent evidence that has not been incorporated into the published systematic reviews. CITA: Clin Transl Allergy. 2017 Aug 8;7:24 DOI: 10.1186/s13601-017-0159-6 PMID: 28898920 TÍTULO: Higher adenoma detection rate with the endocuff: a randomized trial AUTORES: González-Fernández C, García-Rangel D, Aguilar-Olivos NE, Barreto-Zúñiga R, Romano-Munive AF, Grajales-Figueroa G, Zamora-Nava LE, Téllez-Avila FI. BACKGROUND AND STUDY AIM:  Different techniques have been intro- duced to improve the endoscopist's view and enhance the detection of pol- yps. The endocuff is a polymer sleeve cap that is connected to the tip of the colonoscope in order to improve visualization of the mucosa during colonos- copy. The aim of the study was to compare adenoma detection rates (ADR) of endocuff-assisted colonoscopy and conventional colonoscopy. PATIENTS AND METHODS:  Patients 50 years or older were randomized into two groups: an endocuff-assisted colonoscopy group and a convention- al colonoscopy group without the endocuff. RESULTS:  A total of 337patients were included: 174 in the endocuff group and 163 in the conventional group. The median age was 61 years (interquar- tile range 55 - 70 years), and 74 % were women. The ADR was higher in the endocuff group than in the conventional group (22.4 % vs. 13.5 %; P = 0.02). The mean number of adenomas was 0.30 (SD0.25) in the endocuff group and 0.21 (SD 0.26) in the conventional group (P  = 0.02). The rate of ileal intubation was lower in the endocuff group (73 %vs. 87 %; P < 0.001). No seri- ous adverse events occurred with the use of the endocuff. CONCLUSIONS:  Endocuff colonoscopy achieved a greater ADR than con- ventional colonoscopy. CITA: Endoscopy. 2017 Nov; 49(11):1061-1068 DOI: 10.1055/s-0043-117879 PMID: 28902467 TÍTULO: EAACI guidelines on allergen immunotherapy: Prevention of allergy AUTORES: Halken S, Larenas-Linnemann D, Roberts G, Calderón MA, Angier E, Pfaar O, Ryan D, Agache I, Ansotegui IJ, Arasi S, Du Toit G, Fer- nandez-Rivas M, Geerth van Wijk R, Jutel M, Kleine-Tebbe J, Lau S, Matri- cardi PM, Pajno GB, Papadopoulos NG, Penagos M, Santos AF, Sturm GJ, Timmermans F, van Ree R, Varga EM, Wahn U, Kristiansen M, Dhami S, Sheikh A, Muraro A. 252

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR SUMMARY: Allergic diseases are common and frequently coexist. Allergen immunotherapy (AIT) is a disease-modifying treatment for IgE-mediated allergic disease with effects beyond cessation of AIT that may include im- portant preventive effects. The European Academy of Allergy and Clinical Immunology (EAACI) has developed a clinical practice guideline to provide evidence-based recommendations for AIT for the prevention of (i) devel- opment of allergic comorbidities in those with established allergic diseas- es, (ii) development of first allergic condition, and (iii) allergic sensitization. This guideline has been developed using the Appraisal of Guidelines for Research & Evaluation (AGREE II) framework, which involved a multidis- ciplinary expert working group, a systematic review of the underpinning evidence, and external peer-review of draft recommendations. Our key rec- ommendation is that a 3-year course of subcutaneous or sublingual AIT can be recommended for children and adolescents with moderate-to-severe al- lergic rhinitis (AR) triggered by grass/birch pollen allergy to prevent asthma for up to2 years post-AIT in addition to its sustained effect on AR symptoms and medication. Some trial data even suggest a preventive effect on asth- ma symptoms and medication more than 2 years post-AIT. We need more evidence concerning AIT for prevention in individuals with AR triggered by house dust mites or other allergens and for the prevention of allergic sensiti- zation, the first allergic disease, or for the prevention of allergic comorbidities in those with other allergic conditions. Evidence for the preventive potential of AIT as disease-modifying treatment exists but there is an urgent need for more high-quality clinical trials. CITA: Pediatr Allergy Immunol. 2017 Dec; 28(8):728-745 DOI: 10.1111/pai.12807. PMID: 28902467 PMID: 28932383 TÍTULO: Erratum to: Allergen immunotherapy for allergic rhinoconjunctivitis: protocol for a systematic review AUTORES: Dhami S, Nurmatov U, Roberts G, Pfaar O, Muraro A, Anso- tegui IJ, Calderon M, Cingi C, Demoly P, Durham S, van Wijk RG, Halken S, Hamelmann E, Hellings P, Jacobsen L, Knol E, Linnemann DL, Lin S, Maggina V, Oude-Elberink H, Pajno G, Panwankar R, Pastorello E, Pitsios C, Rotiroti G, Timmermans F, Tsilochristou O, Varga EM, Wilkinson J, Williams A, Worm M, Zhang L, Sheikh A. ABSTRACT: Erratum CITA: Clin Transl Allergy. 2017 Sep 15; 7:29 DOI: 10.1186/s13601-017-0168-5 PMID: 29026341 TÍTULO: Benefits of different postoperative treatments in patients undergo- ing knee arthroscopic debridement AUTORES: Trueba Vasavilbaso C, Rosas Bello CD, Medina López E, Cor- onel Granado MP, Navarrete Álvarez JM, Trueba Davalillo CA, Gil Orbezo FI. PURPOSE: To assess the effectiveness of visco supplementation or plate- let-rich plasma (PRP), compared to standard care, for pain relief after knee arthroscopic debridement in patients with meniscal pathology and osteoar- thritis (OA), undernormal clinical practice conditions. 253

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29043011 PATIENTS AND METHODS: We conducted a prospective, randomized, evaluator-blind, pilot study. After arthroscopy, patients were randomized to receive 1) five injections of HA1 (Suprahyal®/Adant®); 2) four injections of HA2 (Orthovisc®); 3) three injections of HA3 (Synvisc®); 4) a single injection of PRP (GPS™ II); or 5) standard care (control). Patients were followed up for 18 months. Clinical outcomes were evaluated using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) at 3, 6, 12, and 18 months. Minimally Clinical Important Improvement (MCII), as relative improvement ≥20 for pain and function, was also calculated. RESULTS: Fifty patients were included. At early follow-up (3 months), total WOMAC scores improved in all groups compared to baseline with reduc- tions of 44.79 %( HA1), 24.02% (HA2), 40.38% (HA3), 39.77% (PRP), and 27.64% (control) (p=0.002HA1 compared to HA2). At 18 months, the higher improvement in total WOMAC was in HA1 with a 65.20% reduction, followed by PRP (55.01%), HA3 (49.57%), and HA2(29.82%), whereas the control group had a 14.55% increase over baseline (p=0.001 control compared to HA1 and HA3). The percentage of patients achieving the MCII for both pain and function at 18 months was 100% (HA1), 80% (HA3), 60% (HA2), and60% (PRP), whereas, in the control group, all patients returned to pre-ar- throscopy levels. There were no adverse events attributable to surgery or to intraarticular administration. CONCLUSION: Visco supplementation following arthroscopy is more effec- tive than PRP in adequately selected patients with meniscal lesions occur- ring concomitantly with OA. Further controlled studies with a larger sample size and/or alternative regimens would be of interest for the scientific com- munity. CITA: Open Access Rheumatol. 2017 Sep 25; 9:171-179 DOI: 10.2147/OARRR.S138353 TÍTULO: Debates in Allergy Medicine: Allergy skin testing cannot be re- placed by molecular diagnosis in the near future AUTORES: Larenas-Linnemann D, Luna-Pech JA, Mösges R. ABSTRACT: Percutaneous skin prick tests (SPT) have been considered the preferred method for confirming IgE-mediated sensitization. This reliable and minimally invasive technique correlates with in vivo challenges, has good reproducibility, is easily quantified, and allows analyzing multiple al- lergens simultaneously. Potent extracts and a proficient tester improve its accuracy. Molecular-based allergy diagnostics (MA-Dx) quantifies allergenic components obtained either from purification of natural sources or recombi- nant technology to identify the patient's reactivity to those specific allergenic protein components. For a correct allergy diagnosis, the patient selection is crucial. MA-Dx has been shown to have a high specificity, however, as MA-Dx testing can be ordered by any physician, the pre-selection of patients might not always be optimal, reducing test specificity. Also, MA-Dx is less sensitive than in vitro testing with the whole allergen or SPT. Secondly, no allergen-specific immunotherapy (AIT) trial has yet shown efficacy with pa- tients selected on the basis of their MA-Dx results. Thirdly, why would we need molecular diagnosis, as no molecular treatment can yet be offered? Then there are the practical arguments of costs (SPT highly cost-efficient), test availability for MA-Dx still lacking in wide areas of the world and scarce in others. As such, it is hard physicians can build confidence in the test and their interpretation of the MA-Dx results. IN 254

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29073934 CONCLUSION: as of now these techniques should be reserved for situa- PMID: 29075437 tions of complex allergies and polysensitization; in the future MA-Dx might help to reduce the number of allergens for AIT, but trials are needed to prove PMID: 29080337 this concept. CITA: World Allergy Organ J. 2017 Sep 19; 10(1):32 DOI: 10.1186/s40413-017-0164-1 TÍTULO: Noninvasive ventilation in hypercapnic chronic obstructive pulmo- nary disease AUTORES: Ñamendys-Silva SA. SUMMARY: Letter to the editor CITA: Crit Care. 2017 Oct 26; 21(1):266 DOI: 10.1186/s13054-017-1854-3 TÍTULO: CHRODIS criteria applied to the MASK (MACVIA-ARIA Sentinel NetworK) Good Practice in allergic rhinitis: a SUNFRAIL report AUTORES: Bousquet J, (…) Larenas-Linnemann D, et al. ABSTRACT: A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initia- tive, is an example of a Good Practice focusing on the implementation of multi-sectoral care pathways using emerging technologies with real life data in rhinitis and asthma multi-morbidity. The European Union Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS) has developed a checklist of 28 items for the evaluation of Good Practices. SUNFRAIL (Ref- erence Sites Network for Prevention and Care of Frailty and Chronic Con- ditions in community dwelling persons of EU Countries), a European Union project, assessed whether MASK is in line with the28 items of JA-CHRODIS. A short summary was proposed for each item and 18experts, all members of ARIA and SUNFRAIL from 12 countries, assessed the 28items using a Survey Monkey-based questionnaire. A visual analogue scale (VAS) from 0 (strongly disagree) to 100 (strongly agree) was used. Agreement equal or over 75% was observed for 14 items (50%). MASK is following the JA-CH- RODIS recommendations for the evaluation of Good Practices. CITA: Clin Transl Allergy. 2017 Oct 23; 7:37 DOI: 10.1186/s13601-017-0173-8 TÍTULO: Bile Acids in Health and Disease Foreword AUTORES: Méndez-Sánchez N. SUMMARY: Editorial CITA: Ann Hepatol. 2017 Nov;16(Suppl. 1: s3-105.):s3 DOI: 10.5604/01.3001.0010.5492 255

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29080339 TÍTULO: The Role of the Gut Microbiota in Bile Acid Metabolism AUTORES: Ramírez-Pérez O, Cruz-Ramón V, Chinchilla-López P, Mén- dez-Sánchez N. SUMMARY: The gut microbiota has been considered a cornerstone of main- taining the health status of its human host because it not only facilitates harvesting of nutrients and energy from ingested food, but also produces numerous metabolites that can regulate host metabolism. One such class of metabolites, the bile acids, are synthesized from cholesterol in the liver and further metabolized by the gut microbiota into secondary bile acids. These bioconversions modulate the signaling properties of bile acids through the nuclear farnesoid X receptor and the G protein-coupled membrane receptor 5, which regulate diverse metabolic pathways in the host. In addition, bile acids can regulate gut microbial composition both directly and indirectly by activation of innate immune response genes in the small intestine. There- fore, host metabolism can be affected by both microbial modifications of bile acids, which leads to altered signaling via bile acid receptors, and by alterations in the composition of the microbiota. In this review, we mainly describe the interactions between bile acids and intestinal microbiota and their roles in regulating host metabolism, but we also examine the impact of bile acid composition in the gut on the intestinal microbiome and on host physiology. CITA: Ann Hepatol. 2017 Nov;16(Suppl. 1: s3-105.):s15-s20 DOI: 10.5604/01.3001.0010.5494 PMID: 29080343 TÍTULO: Bile Acids in Nonalcoholic Fatty Liver Disease: New Concepts and therapeutic advances AUTORES: Cruz-Ramón V, Chinchilla-López P, Ramírez-Pérez O, Mén- dez-Sánchez N. SUMMARY: Nonalcoholic liver disease (NAFLD) is a major emerging health burden that is a common cause of illness and death worldwide. NAFLD can progress into nonalcoholic steatohepatitis (NASH) which is a severe form of liver disease characterized by inflammation and fibrosis. Further progression leads to cirrhosis, which predisposes patients to hepatocellular carcinoma or liver failure. The mechanism of the progression from simple steatosis to NASH is unclear. However, there are theories and hypothesis which support the link between disruption of the bile acids homeostasis and the progression of this disorder. Previous studies have been demonstrated that alterations to these pathways can lead to dysregulation of energy balance and increased liver inflammation and fibrosis. In this review, we summarized the current knowledge of the interaction between BA and the process related to the de- velopment of NAFLD, besides, the potential targets for novel therapies. CITA: Ann Hepatol. 2017 Nov;16(Suppl. 1: s3-105.):s58-s67 DOI: 10.5604/01.3001.0010.5498 PMID: 29108768 TÍTULO: Worldwide allergen immunotherapy guidelines: Evidence and ex- perience-based AUTORES: Larenas-Linnemann DES. ABSTRACT: Review article 256

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR CITA: Allergol Immunopathol (Madr). 2017 Dec; 45 Suppl 1:17-22 DOI: 10.1016/j.aller.2017.09.005 PMID: 29118282 TÍTULO: The Role of Bile Acids in Glucose Metabolism and Their Relation PMID: 29142747 with Diabetes AUTORES: González-Regueiro JA, Moreno-Castañeda L, Uribe M, Chávez-Tapia NC. SUMMARY: Bile acids (BAs), the end products of cholesterol catabolism, are essential for the absorption of lipids and fat-soluble vitamins; but they have also emerged as novel signaling molecules that act as metabolic regulators. It has been well described that the enterohepatic circulation, a nuclear (FXR) and a cytoplasmic (TGR5/M-BAR) receptor aid in controlling hepatic bile acid synthesis. Modulating bile acid synthesis greatly impacts in metabolism, be- cause these receptors also are implicated in glucose, lipid, and energy ex- penditure. Recent studies had revealed the way these receptors participate in regulating gluconeogenesis, peripheral insulin sensitivity, glycogen syn- thesis, glucagon like peptide 1(GLP-1) and insulin secretion. Nowadays, it is demonstrated that enhancing bile acid signaling in the intestine contributes to the metabolic benefits of bile acid sequestrants and bariatric surgery on glucose homeostasis. This paper discusses the role of bile acid as regulators of glucose metabolism and their potential as therapeutic targets for diabetes. CITA: Ann Hepatol. 2017 Nov; 16(Suppl. 1: s3-105.): 16-21 DOI: 10.5604/01.3001.0010.5672 TÍTULO: Clinical characteristics of critically ill cancer patients who are un- dergoing isolated limb perfusion AUTORES: Ñamendys-Silva SA, Ruiz-Beltran AM, Barragán-Dessavre M, Bautista-Ocampo AR, Meneses-García A, González-Chon O, Herrera-Gómez A. SUMMARY: The aim of the present study was to investigate the incidence of organ dysfunction, and to describe the clinical characteristics and intensive care unit (ICU) outcomes of critically ill cancer patients who were admitted to an oncological ICU during the isolated limb perfusion post-operative pe- riod. The present study was an observational investigation of 42 critically ill cancer patients who were admitted to the ICU of the Instituto Nacional de Cancerología, during the isolated limb perfusion post-operative period, between July 2010 and February 2016. The mean age of the patients was 45.7±16.9 years, and 45.2% (19cases) were female. Soft tissue sarcoma was the most common pre-operative diagnosis (38.1%), and the mean dura- tion of surgery was 267.6±50.1 min. Furthermore, a mean blood loss volume of 732.3±526.1 ml during the procedure was recorded, and the patients re- ceived a mean volume of 3.88±1.28 l crystalloid fluid during the surgical pro- cedure, subsequently requiring an additional2.95±6.28 l on the first post-op- erative day. The incidence of organ dysfunction was 90.5% and was most frequently noted in the respiratory (81%), hepatic (33%), hematologic (31%) and renal (11.9%) systems. No patients succumbed to the disease during the ICU and hospital stay. Nevertheless, <10% of the patients required vaso- pressors. Additionally, <5% of the patients required invasive mechanical ven- tilation. Therefore, ICU admission directly following isolated limb perfusion should not be standardized. CITA: Mol Clin Oncol. 2017 Nov; 7(5):747-750 DOI: 10.3892/mco.2017.1401 257

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29171249 TÍTULO: Chronic venous disease treated with sulodexide: a survey among primary care physicians in Mexico PMID: 29185254 AUTORES: Flota Cervera LF, Frati Munari AC, Velázquez Herrera ÁE, Car- PMID: 29214164 bajal Contreras A. BACKGROUND: Sulodexide is a glycosaminoglycan approved for the treat- ment of chronic venous disease (CVD). It has been available in Mexico since 2012. The aim of the study was to understand the clinical experience of pri- mary care physicians in the treatment of CVD with sulodexide. METHODS: Clinical data collection forms were distributed among general practitioners. Data was collected for up to four follow-up consultations. All signs and symptoms were rated with the Likert Scale at each examination: 0 to 5(where 0 means none, and 5 very severe). Both the patient's and the physician's opinions of the effects of the treatment were recorded. RESULTS: Data were collected from 1599 patients at different clinical stages of CVD, 52% of which were at advanced stages (C4-C6). A total of 434 cases were followed up with four examinations (median of thirty days between each examination). In these cases, the overall sign and symptom score decreased significantly at each examination (P<0.01). At the fourth examination, 98.9% of the patients felt better or much better than at the first examination, and 99.7% were better or much better in the physician's opin- ion (P<0.01). The only adverse effect was nausea, reported in two cases. CONCLUSIONS: Sulodexide was effective and well tolerated in the treat- ment of CVD. CITA: Int Angiol. 2017 Dec; 36(6):558-564 DOI: 10.23736/S0392-9590.17.03805-6 TÍTULO: Technical comment on: Biskup E, et al. Oncological patients in the intensive care unit: prognosis, decision-making, therapies and end-of-life care AUTORES: Ñamendys-Silva SA. SUMMARY: Letter to the editor CITA: Swiss Med Wkly. 2017 Nov 23; 147:w14557 DOI: 10.4414/smw.2017.14557 TÍTULO: Outcome of Critically Ill Patients with Testicular Cancer AUTORES: Ñamendys-Silva SA, Barragán-Dessavre M, Bautista-Ocam- po AR, García-Guillén FJ, Córdova-Sánchez BM, Constantino-Hérnandez E, Correa-García P, González-Chon O, Herrera-Gómez A. PURPOSE: To evaluate the clinical characteristics and outcomes of critically ill patients with testicular cancer (TC) admitted to an oncological intensive care unit (ICU). METHODS: This was a prospective observational study. There were no in- terventions. 258

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR RESULTS: During the study period, 1,402 patients with TC were admitted to the Department of Oncology, and 60 patients (4.3%) were admitted to the ICU. The most common histologic type was non seminomatous germ cell tumors (55/91.7%). The ICU, hospital, and 6-month mortality rates were 38.3%, 45%, and 63.3%, respectively. The Cox multivariate analysis iden- tified the white blood cells count (HR = 1.06, 95% CI = 1.01-1.11, and P = 0.005), ionized calcium (iCa) level (HR = 1.23, 95%CI = 1.01-1.50, and P = 0.037), and 2 or more organ failures during the first 24 hours after ICU admission (HR = 3.86, 95% CI = 1.96-7.59, and P < 0.001) as independent predictors of death for up to 6 months. CONCLUSION: The ICU, hospital, and 6-month mortality rates were 38.3%, 45%, and63.3%, respectively. The factors associated with an increased 6-month mortality rate were white blood cells count, iCa level, and 2 or more organ failures during the first 24 hours after ICU admission. CITA: Biomed Res Int. 2017; 2017:3702605 DOI: 10.1155/2017/3702605 PMID: 29254220 TÍTULO: Expression of PD-1/PD-L1 and PD-L2 in peripheral T-cells from non-small cell lung cancer patients AUTORES: Arrieta O, Montes-Servín E, Hernandez-Martinez JM, Cardona AF, Casas-Ruiz E, Crispín JC, Motola D, Flores-Estrada D, Barrera L. SUMMARY: Binding of programmed death-1 (PD-1) with its ligands (PD- L1/2) transmits aco-inhibitory signal in activated T-cells that promotes T-cell exhaustion, leading to tumor immune evasion. The efficacy of antibodies tar- geting PD-1 andPD-L1 has led to a paradigm shift in lung cancer treatment but the prognostic and predictive value of tumor PD-L1 expression remains controversial. EvaluatingPD-1, PD-L1/2 expression in peripheral blood cells may serve as a potential biomarker for prognosis and response to therapy. In this prospective observational study, plasma cytokine levels and PD-1, PD- L1 and PD-L2 expression was evaluated in circulating CD3+, CD3+CD4+ and CD3+CD8+ cells from 70treatment-naïve patients with advanced NS- CLC (Stage IIIB and IV) and from 10healthy donors. The primary objective was to assess OS according to PD-1, PD-L1, PD-L2 expression status on PBMCs and lymphocyte subsets. Our results indicate that the percentage of PD-L1+CD3+, PD-L1+CD3+CD8+ PD-L2+PBMCs, PD-L2+CD3+, PD-L2+C- D3+CD4+ cells was higher in patients than in healthy donors. Survival was decreased among patients with a high percentage of either PD-1+PBMCs, PD-1+CD3+, PD-L1+CD3+, PD-L1+CD3+CD8+, PD-L2+CD3+, PD-L2+C- D3+CD4+, or PD-L2+CD3+CD8+ cells. IL-2 and TNF-α showed the stron- gest association with PD-L1 and PD-L2 expression on specific subsets of T-lymphocytes. Our findings suggest that increasedPD-1/PD-L1/PDL-2 ex- pression in PBMCs, particularly in T-cells, may be an additional mechanism leading to tumor escape from immune control. This study is registered with ClinicalTrials.gov, number NCT02758314. CITA: Oncotarget. 2017 Oct 24; 8(60):101994-102005 DOI: 10.18632/oncotarget.22025 259

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29340273 TÍTULO: Effects of Portal Vein Thrombosis on the Outcomes of Liver Cirrho- PMID: 29456472 sis: A Mexican Perspective AUTORES: Cruz-Ramón V, Chinchilla-López P, Ramírez-Pérez O, Mén- PMID: 29518297 dez-Sánchez N. SUMMARY: Editorial CITA: J Transl Int Med. 2017 Dec 29; 5(4):189-191 DOI: 10.1515/jtim-2017-0031 TÍTULO: Electron Beam Intraoperative Radiotherapy (ELIOT) in Pregnant Women with Breast Cancer: From in Vivo Dosimetry to Clinical Practice AUTORES: Leonardi M, Cecconi A, Luraschi R, Rondi E, Cattani F, Lazzari R, Morra A, Soto S, Zanagnolo V, Galimberti V, Gentilini O, Peccatori F, Je- reczek-Fossa B, Orecchia R. BACKGROUND: The aim of this study was to confirm our preliminary re- sults with in vivo dosimetry in non-pregnant breast cancer patients receiving electron beam intraoperative radiotherapy (ELIOT) and to report on the first treatment in a pregnant woman. PATIENTS AND METHODS: Following our previous experience, 5 non-preg- nant patients receiving ELIOT to the tumor bed after breast-conserving sur- gery (BCS) were studied with thermoluminescent dosimeters positioned in the subdiaphragmatic region, within the uterus, and in the ovarian region. In December 2011, the first pregnant breast cancer patient underwent BCS and ELIOT (21 Gy at 90% isodose) during the 15th week of gestation. RESULTS: The mean dose to the subdiaphragmatic external region in the 5non-pregnant patients was 5.57 mGy, while pelvic measurements were be- low 1 mGy. The actual dosimetry of the pregnant patient showed a mean subdiaphragmatic dose of 4.34 mGy, a mean suprapubic dose of 1.64 mGy, and mean ovarian doses of 1.48mGy (right-sided) and 1.44 mGy (left-sided). The expected dose to the fetus was estimated as 0.84 mGy (0.004% of the prescribed dose). CONCLUSION: ELIOT as an anticipated boost to the breast could be con- sidered in pregnant women in the early second trimester, postponing whole- breast irradiation after delivery. CITA: Breast Care (Basel). 2017 Dec;12(6):396-400 DOI: 10.1159/000479862 TÍTULO: [Rotator cuff tear athropathy prevalence] AUTORES: Guerra-Soriano F, Encalada-Díaz MI, Ruiz-Suárez M, Vale- ro-González FS. INTRODUCTION: Glenohumeral arthritis secondary to massive rotator cuff tear presents with a superior displacement and femoralization of the humeral head with coracoacromial arch acetabularization. The purpose of this study was to es- tablish prevalence of rotator cuff tear artropathy (CTA) at our institution. 260

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR MATERIAL AND METHODS: Four hundred electronic records were reviewed from which we identified 136 patients with rotator cuff tears. A second group was composed with patients with massive cuff tears that were analized and staged by the Seebauer cuff tear arthropathy classification. RESULTS: Thirty four patients with massive rotator cuff tears were identified, 8 male and 26 female (age 60.1 ± 10.26 years). Massive rotator cuff tear prev- alence was 25%. CTA prevalence found in the rotator cuff group was 19 and 76% in the massive cuff tears group. Patients were staged according to the classification with 32% in stage 1a, 11% 1b, 32% 2a and 0% 2b. CONCLUSION: CTA prevalence in patients with rotator cuff tears and mas- sive cuff tears is higher than the one reported in American population. We consider that a revision of the Seebauer classification to be appropriate to determine its reliability. CITA: Acta Ortop Mex. 2017 Sep-Oct; 31(5):228-232 PMID: 30334003 TÍTULO: Outcomes of Metastatic Chromophobe Renal Cell Carcinoma (chr- RCC) in the Targeted Therapy Era: Results from the International Metastatic Renal Cell Cancer Database Consortium (IMDC) AUTORES: Yip SM, Ruiz Morales JM, Donskov F, Fraccon A, Basso U, Rini BI, Lee JL, Bjarnason GA, Sim HW, Beuselinck B, Kanesvaran R, Bru- garolas J, Koutsoukos K, Fu SYF, Yuasa T, Davis I, Alva A, Kollmannsberger C, Choueiri TK, Heng DYC. BACKGROUND: Treatment outcomes are poorly characterized in patients with metastatic chromophobe renal cell cancer (chrRCC), a subtype of renal cell carcinoma. OBJECTIVE: This retrospective series aims to determine metastatic chrRCC treatment outcomes in the targeted therapy era. Methods: A retrospective data analysis was performed using the IMDC dataset of 4970 patients to determine metastatic chrRCC treatment outcomes in the targeted therapy era. RESULTS: 109/4970 (2.2%) patients had metastatic chrRCC out of all pa- tients with mRCC treated with targeted therapy. These patients were com- pared with 4861/4970(97.8%) clear cell mRCC (ccRCC) patients. Patients with metastatic chrRCC had a similar OS compared to patients with ccRCC (23.8 months (95% CI 16.7 - 28.1) vs22.4 months (95% CI 21.4 - 23.4), re- spectively (p = 0.0908). Patients with IMDC favorable (18%), intermediate (59%) and poor risk (23%) had median overall survivals of 31.4, 27.3, and 4.8 months, respectively (p = 0.028). CONCLUSIONS: To the authors' knowledge, this is the largest series of metastatic chrRCC patients and these results set new benchmarks for sur- vival in clinical trial design and patient counseling. The IMDC criteria risk categories seem to stratify patients into appropriate favourable, intermedi- ate, and poor risk groups, although larger patient numbers are required. It appears that outcomes between metastatic chrRCC and ccRCC are similar when treated with conventional targeted therapies. Patients with metastatic chrRCC can be treated with tyrosine kinase inhibitors and enrolled in clinical trials to further measure outcomes in this rare patient population. CITA: Kidney Cancer. 2017 Jul 26; 1(1):41-47 DOI: 10.3233/KCA-160002 261

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 31171341 TÍTULO: Reply: Could TIPS be Applied in All Kinds of Portal Vein Thrombosis: We are not Sure! AUTORES: Chinchilla-López P, Ramírez-Pérez O, Cruz-Ramón V, Mén- dez-Sánchez N. PMID: 31196630 SUMMARY: Letter to the editor PMID: 31196631 CITA: Ann Hepatol. 2017 Nov - Dec; 16(6):979-980 DOI: 10.5604/01.3001.0010.5292 TÍTULO: The Role of Bile Acids in Glucose Metabolism and Their Relation with Diabetes AUTORES: Alberto González-Regueiro J, Moreno-Castañeda L, Uribe M, Carlos Chávez-Tapia N. SUMMARY: Bile acids (BAs), the end products of cholesterol catabolism, are essential for the absorption of lipids and fat-soluble vitamins; but they have also emerged as novel signaling molecules that act as metabolic regulators. It has been well described that the enterohe-patic circulation, a nuclear (FXR) and a cytoplasmic (TGR5/M-BAR) receptor aid in controlling hepatic bile acid synthesis. Modulating bile acid synthesis greatly impacts in metabolism, because these receptors also are implicated in glucose, lipid, and energy expenditure. Recent studies had revealed the way these recep- tors participate in regulating gluconeogenesis, peripheral insulin sensitivity, glycogen synthesis, glucagon like peptide 1 (GLP-1) and insulin secretion. Nowadays, it is demonstrated that enhancing bile acid signaling in the intes- tine contributes to the metabolic benefits of bile acid sequestrants and bar- iatric surgery on glucose homeos-tasis. This paper discusses the role of bile acid as regulators of glucose metabolism and their potential as therapeutic targets for diabetes. CITA: Ann Hepatol. 2017 Nov;16 Suppl 1:S15-S20 DOI: 10.5604/01.3001.0010.5494 TÍTULO: The Role of the Gut Microbiota in Bile Acid Metabolism AUTORES: Ramírez-Pérez O, Cruz-Ramón V, Chinchilla-López P, Mén- dez-Sánchez N. SUMMARY: The gut microbiota has been considered a cornerstone of main- taining the health status of its human host because it not only facilitates harvesting of nutrients and energy from ingested food, but also produces numerous metabolites that can regulate host metabolism. One such class of metabolites, the bile acids, are synthesized from cholesterol in the liver and further metabolized by the gut microbiota into secondary bile acids. These bioconversions modulate the signaling properties of bile acids through the nuclear farnesoid X receptor and the Gprotein-coupled membrane receptor 5, which regulate diverse metabolic pathways in the host. In addition, bile acids can regulate gut microbial composition both directly and indirectly by activation of innate immune response genes in the small intestine. There- fore, host metabolism can be affected by both microbial modifications of bile acids, which leads to altered signaling via bile acid receptors, and by 262

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR alterations in the composition of the microbiota. In this review, we mainly describe the interactions between bile acids and intestinal microbiota and their roles in regulating host metabolism, but we also examine the impact of bile acid composition in the gut on the intestinal microbiome and on host physiology. CITA: Ann Hepatol. 2017 Nov; 16 Suppl 1:S21-S26 DOI: 10.5604/01.3001.0010.5672 PMID: 31196633 TÍTULO: Bile Acids in Health and Disease Foreword AUTORES: Méndez-Sánchez N. SUMMARY: Editorial CITA: Ann Hepatol. 2017 Nov; 16 Suppl 1:S3 DOI: 10.5604/01.3001.0010.5492 PMID: 31196637 TÍTULO: Bile Acids in Nonalcoholic Fatty Liver Disease: New Concepts and Therapeutic Advances AUTORES: Cruz-Ramón V, Chinchilla-López P, Ramírez-Pérez O, Mén- dez-Sánchez N. SUMMARY: Nonalcoholic liver disease (NAFLD) is a major emerging health burden that is a common cause of illness and death worldwide. NAFLD can progress into non alcoholic steatohepatitis (NASH) which is a severe form of liver disease characterized by inflammation and fibrosis. Further progression leads to cirrhosis, which predisposes patients to hepatocellular carcinoma or liver failure. The mechanism of the progression from simple steatosis to NASH is unclear. However, there are theories and hypothesis which support the link between disruption of the bile acids homeostasis and the progression of this disorder. Previous studies have been demonstrated that alterations of these pathways can lead to dysregulation of energy balance and an increase of liver inflammation and fibrosis. In this review, we summarized the current knowl- edge of the interaction between BA and theprocess related to the development of NAFLD, besides, the potential targets fornovel therapies. CITA: Ann Hepatol. 2017 Nov; 16 Suppl 1:S58-S67 DOI: 10.5604/01.3001.0010.5498 2018 PMID: 28600902 TÍTULO: Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (MACVIA-ARIA) - EIP on AHA Twinning Reference Site (GARD research demonstration project) AUTORES: Bousquet J, (…) Larenas-Linnemann D, et al. ABSTRACT: The overarching goals of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) are to enable European citizens 263

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 28684034 to lead healthy, active and independent lives whilst ageing. The EIP on AHA PMID: 28906011 includes 74 Reference Sites. The aim of this study was to transfer innova- tion from an app developed by the MACVIA-France EIP on AHA reference site (Allergy Diary) to other reference sites. The phenotypic characteristics of rhinitis and asthma multimorbidity in adults and the elderly will be compared using validated information and communication technology (ICT) tools (i.e. the Allergy Diary and CARAT: Control of Allergic Rhinitis and Asthma Test) in 22 Reference Sites or regions across Europe. This will improve the under- standing, assessment of burden, diagnosis and management of rhinitis in the elderly by comparison with an adult population. Specific objectives will be: (i) to assess the percentage of adults and elderly who are able to use the Allergy Diary, (ii) to study the phenotypic characteristics and treatment over a 1-year period of rhinitis and asthma multimorbidity at baseline (cross-sec- tional study) and (iii) to follow-up using visual analogue scale (VAS). This part of the study may provide some insight into the differences between the elderly and adults in terms of response to treatment and practice. Finally (iv) work productivity will be examined in adults. CITA: Allergy. 2018 Jan; 73(1):77-92 DOI: 10.1111/all.13218 TÍTULO: Present and past perspectives on Clostridium difficile infection AUTORES: Álvarez-Hernández DA, González-Chávez AM, González-Her- mosillo-Cornejo D, Franyuti-Kelly GA, Díaz-Girón-Gidi A, Vázquez-López R. SUMMARY: Clostridium difficile is a Gram-positive bacillus that has become one of the main hospital-acquired human gastrointestinal infections in re- cent years. Its incidence is on the rise, involving more virulent strains, affect- ing new and previously uncontemplated groups of patients, and producing changes in clinical presentation and treatment response that influence dis- ease outcome. Early diagnosis and disease stratification based on the sever- ity of C.difficile infection are essential for therapeutic management and the implementation of containment measures. However, the speed at which new strains with greater pathogenicity are developing is surpassing that of the development of new drugs, making it necessary to validate other therapeutic options. The present article is a review of the epidemiologic, pathophysio- logic, diagnostic, and therapeutic aspects of C.difficile infection, from its first isolation to the present date, that aims to contribute to the preparation of general physicians and specialists, so that patients with this infection receive opportune and quality medical attention. CITA: Rev Gastroenterol Mex. 2018 Jan - Mar; 83(1):41-50 DOI: 10.1016/j.rgmx.2017.03.004 TÍTULO: The Allergic Rhinitis and its Impact on Asthma (ARIA) score of allergic rhinitis using mobile technology correlates with quality of life: The MASK study AUTORES: Bousquet J, (…) Larenas-Linnemann D, et al. ABSTRACT: Mobile technology has been used to appraise allergic rhinitis control, but more data are needed. To better assess the importance of mo- bile technologies in rhinitis control, the ARIA (Allergic Rhinitis and its Impact on Asthma) score ranging from 0 to 4 of the Allergy Diary was compared with EQ-5D (EuroQuol) and WPAI-AS (Work Productivity and Activity Impairment 264

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 28906252 in allergy) in 1288 users in18 countries. This study showed that quality-of-life PMID: 28920710 data (EQ-5D visual analogue scale and WPA-IS Question 9) are similar in users without rhinitis and in those with mild rhinitis (scores 0-2). Users with a score of 3 or 4 had a significant impairment in quality-of-life question- naires. CITA: Allergy. 2018 Feb; 73(2):505-510 DOI: 10.1111/all.13307 TÍTULO: The Work Productivity and Activity Impairment Allergic Specific (WPAI-AS) Questionnaire Using Mobile Technology: The MASK Study AUTORES: Bousquet J, (…) Larenas-Linnemann D, et al. ABSTRACT: Letter to the editor CITA: J Investig Allergol Clin Immunol. 2018;28(1):42-44 DOI: 10.18176/jiaci.0197 TÍTULO: Use of strong opioids for chronic pain in osteoarthritis: an insight into the Latin American reality AUTORES: Ruiz Iban MA, Benavides J, Forero JP, Bittelman S, Martinez R, Mite MA, Diaz Heredia J, Ulloa S, Lizárraga Ferrand MM. INTRODUCTION: Osteoarthritis is the most common cause of arthritis and one of the main causes of chronic pain. Although opioids are frequently em- ployed for chronic pain treatment, their usage for osteoarthritis pain remains controversial due to the associated adverse effects. Most guidelines reserve their use for refractory pain in patients with hip and knee osteoarthritis. The situation is even more complex in Latin America, where the prevalence of insufficient pain treatment is high because of the limited availability and use of strong opioids. Areas covered: In this article we review the epidemiolo- gy of osteoarthritis, its socioeconomic burden, its impact as a chronic pain cause and the pharmacological treatment options, giving emphasis to the role of strong opioids, their safety and efficacy, especially in Latin American countries, where restrictions regulate their usage. Expert commentary: Us- age of strong opioids is safe and effective in the short-term management of osteoarthritis with moderate to severe pain, when other pharmacological treatments are inadequate and surgery is contraindicated, provided their use adheres to existing guidelines. Educational programs for patients and phy- sicians and further research on treating chronic pain with opioids should be implemented to reduce adverse effects and improve care quality. CITA: Expert Rev Clin Pharmacol. 2018 Jan; 11(1):47-59 DOI: 10.1080/17512433.2018.1381556 PMID: 28940450 TÍTULO: National clinical practice guidelines for allergen immunotherapy: An international assessment applying AGREE-II AUTORES: Larenas-Linnemann DES, Antolín-Amérigo D, Parisi C, Na- konechna A, Luna-Pech JA, Wedi B, Davila I, Gómez M, Levin M, Ortega Mar- tell JA, Klimek L, Rosario N, Muraro AM, Agache I, Bousquet J, Sheikh A 265

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 28940458 BACKGROUND: Since 1988, numerous allergen immunotherapy guidelines (AIT-GLs) have been developed by national and international organizations to guide physicians in AIT. Even so, AIT is still severely underused. OBJECTIVE: To evaluate AIT-GLs with AGREE-II, developed in 2010 by McMaster University methodologists to comprehensively evaluate GL quality. METHODS: Allergist, from different continents, knowledgeable in AIT and AGREE-II trained were selected into the project team. The project received methodologists' guidance. AIT-GLs in any language were sought from 1980 to 2016; AIT-GLs were AGREE II-evaluated by at least 2 team members, independently; discrepancies were resolved in a second round, by team dis- cussion or methodologists' consulting. RESULTS: We found 31 AIT-GLs (15 post-2010), ranging from local consen- sus reports to international position papers (EAACI, AAAAI-ACAAI, WAO). Pre-2010 GLs scored1.6-4.6 (23%-67%) and post-2010 GLs scored 2.1-6 (30%-86%), on a 7-point Likert scale. The highest scores went to: Ger- man-Austrian-Swiss (6.0), Mexican (5.1), and the AAAAI/ACAAI AIT-GL (4.7). These were also the only 3 GLs that received \"yes\" of both evaluators to the item: \"I would recommend this GL for use.\" The domains of \"Stakeholder involvement\" and \"Rigor of Development\" only scored 3/7, and \"Applicability\" scored the lowest. Strikingly, newer GLs only scored clearly better in \"Edito- rial independence\" and \"Global evaluation.\" CONCLUSIONS: In AIT-GLs, there is still a lot of room for improvement, es- pecially in domains crucial for the dissemination. For some GLs, the \"Sci- entific rigor\" domain flawed. When resources are limited, transculturizing a high-quality GL might be preferable over developing a GL from zero. Our study and AGREE-II could help to select the best candidate. CLINICAL IMPLICATIONS: We here evaluate allergen immunotherapy guideline (AIT-GL) quality. Only high-quality AIT-GLs should be consulted for AIT management decisions. In low-resource settings, transculturization of these is preferred over developing low-quality guidelines. CITA: Allergy. 2018 Mar; 73(3):664-672 DOI: 10.1111/all.13316 TÍTULO: EAACI Guidelines on Allergen Immunotherapy: Allergic rhinocon- junctivitis AUTORES: Roberts G, (…) Larenas-Linnemann D, et al. ABSTRACT: Allergic rhino conjunctivitis (AR) is an allergic disorder of the nose and eyes affecting about a fifth of the general population. Symptoms of AR can be controlled with allergen avoidance measures and pharmaco- therapy. However, many patients continue to have ongoing symptoms and an impaired quality of life; pharmacotherapy may also induce some side-ef- fects. Allergen immunotherapy (AIT) represents the only currently available treatment that targets the underlying pathophysiology, and it may have a disease-modifying effect. Either the subcutaneous (SCIT) or sublingual (SLIT) routes may be used. This Guideline has been prepared by the Euro- pean Academy of Allergy and Clinical Immunology’s (EAACI) Taskforce on AIT for AR and is part of the EAACI presidential project \"EAACI Guidelines 266

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR on Allergen Immunotherapy.\" It aims to provide evidence-based clinical recommendations and has been informed by a formal systematic review and meta-analysis. Its generation has followed the Appraisal of Guidelines for Research and Evaluation (AGREE II) approach. The process included involvement of the full range of stakeholders. In general, broad evidence for the clinical efficacy of AIT for AR exists but a product-specific evaluation of evidence is recommended. In general, SCIT and SLIT are recommended for both seasonal and perennial AR for its short-term benefit. The strongest evidence for long-term benefit is documented for grass AIT (especially for the grass tablets) where long-term benefit is seen. To achieve long-term efficacy, it is recommended that a minimum of 3 years of therapy is used. Many gaps in the evidence base exist, particularly around long-term benefit and use in children. CITA: Allergy. 2018 Apr;73(4):765-798 DOI: 10.1111/all.13317 PMID: 29033200 TÍTULO: Validation of a Spanish version of the EuroPrevall Food Allergy Quality of Life Questionnaire-Parental Form AUTORES: Bartoll E, Nieto M, Selva B, Badillo R, Pereira G, Uixera S, Nie- to A, Mazón Á. BACKGROUND: Food allergy can have a major impact on quality of life of children and their parents. Questionnaires have been developed to measure the impact of this disorder. We aimed to validate the Euro Prevall question- naire on Food Allergy-Quality of Life Questionnaire, Parent Form (FAQLQ- PF) and the Food Allergy Independent Measure (FAIM), translated into Spanish. METHODS: The internal consistency of the FAQLQ-PF and the FAIM, trans- lated into Spanish (Spain) and completed by the parents of 74 children with IgE-mediated food allergy, were evaluated with Cronbach's alpha. To test construct validity of the FAQLQ-PF, its correlation with the FAIM was also calculated. To assess their discriminant validity, we compared the values of both depending on the number of offending foods and for children with and without anaphylaxis. RESULTS: The values of Cronbach's alpha for the three domains in the FAQLQ-PF were over 0.9. The value of alpha for FAIM questions was below 0.6, which was attributed to the wording of one question. When this question was removed, alpha increased to over 0.70. There was a significant correla- tion between the FAQLQ-PF score and the FAIM. There were significantly poorer FAQLQ-PF scores in children with more food allergies and worse FAIM in those who had had anaphylaxis. CONCLUSIONS: The Spanish version of the FAQLQ-PF had a good internal consistency, good construct validity and validity to discriminate patients with more food allergies and anaphylaxis. It can be used as a tool to evaluate and monitor the quality of life in families with food allergic children. CITA: Allergol Immunopathol (Madr). 2018 Jan - Feb;46(1):82-86 DOI: 10.1016/j.aller.2017.06.004 267

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29096551 TÍTULO: Moving toward consensus on diagnosis and management of se- vere asthma in children PMID: 29171864 AUTORES: Larenas-Linnemann D, Nieto A, Palomares O, Pitrez PM, PMID: 29180076 Cukier G. SUMMARY: Children with severe asthma continue to experience symptoms despite long-term treatment with high doses of corticosteroids. Moreover, the heterogeneous nature of asthma and the presence of several pheno- types have limited our ability to develop an optimized management strate- gy for these patients. Adequate management of severe asthma in children necessitates a detailed understanding of what makes asthma difficult to control, knowledge of the causal factors, review of diagnosis for accurate identification of pediatric patients with severe asthma and a precise defini- tion of the phenotypes to be able to better target the therapy. Advancement in all these aspects is likely to improve childhood asthma treatment in the future. Although our understanding of severe pediatric asthma has grown in recent years, there remains a lack of consensus and clarity around critical aspects of this condition. This review attempts to present a harmonized view on the definition of severe asthma in the pediatric age group, identification of phenotypes and diagnosis, the inflammatory cascade, pharmacological and non-pharmacological treatment strategies, considerations for follow-up and referral to specialists, and disease prevention strategies. CITA: Curr Med Res Opin. 2018 Mar; 34(3):447-458. DOI: 10.1080/03007995.2017.1400961 TÍTULO: Who should receive endoscopic variceal ligation after recovering from acute variceal bleeding? AUTORES: Qi X, Méndez-Sánchez N, Mancuso A, Romeiro FG, Guo X. SUMMARY: Letter to the editor CITA: Hepatology. 2018 May; 67(5):2057-2058 DOI: 10.1002/hep.29684 TÍTULO: Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines AUTORES: Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C. PURPOSE: Few studies have reported large inter-observer variations in tar- get volume selection and delineation in patients treated with radiotherapy for head and neck squamous cell carcinoma. Consensus guidelines have been published for the neck nodes (see Grégoire et al., 2003, 2014), but such rec- ommendations are lacking for primary tumour delineation. For the latter, two 268

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29189394 main schools of thoughts are prevailing, one based on geometric expansion of the Gross Tumour Volume (GTV) as promoted by DAHANCA, and the other one based on anatomical expansion of the GTV using compartmental- ization of head and neck anatomy. METHOD: For each anatomic location within the larynx, hypopharynx, oro- pharynx and oral cavity, and for each T-stage, the DAHANCA proposal has been comprehensively reviewed and edited to include anatomic knowledge into the geometric Clinical Target Volume (CTV) delineation concept. A first proposal was put forward by the leading authors of this publication (VG and CG) and discussed with opinion leaders in head and neck radiation oncology from Europe, Asia, Australia/New Zealand, North America and South Ameri- ca to reach a worldwide consensus. RESULTS: This consensus proposes two CTVs for the primary tumour, the so calledCTV-P1 and CVT-P2, corresponding to a high and lower tumour burden, and which should be associated with a high and a lower dose pre- scription, respectively. CONCLUSION: Implementation of these guidelines in the daily practice of radiation oncology should contribute to reduce treatment variations from cli- nicians to clinicians, facilitate the conduct of multi-institutional clinical trials, and contribute to improved care of patients with head and neck carcinoma. CITA: Radiother Oncol. 2018 Jan; 126(1):3-24 DOI: 10.1016/j.radonc.2017.10.016 TÍTULO: Ischemic stroke in liver cirrhosis: epidemiology, risk factors, and in-hospital outcomes AUTORES: Zhang X, Qi X, Yoshida EM, Méndez-Sánchez N, Hou F, Deng H, Wang X, Qiu J, He C, Wang S, Guo X. BACKGROUND AND AIMS: Patients with cirrhosis are reportedly more prone to develop hemorrhagic stroke, thereby increasing the risk of death. However, the effect of ischemic stroke on liver diseases remains unclear. In addition, few studies have explored the risk factors for ischemic stroke in patients with liver cirrhosis. Our study aimed to explore the epidemiology, risk factors, and in-hospital outcomes of ischemic stroke in a large cohort of hospitalized patients with cirrhosis. PATIENTS AND METHODS: In this single-center observational study, we retrospectively reviewed the medical records of patients with liver cirrhosis admitted to our hospital from January 2011 to June 2014. A diagnosis of ischemic stroke was further identified. çRESULTS: Of the 2444 patients with liver cirrhosis, 160 had ischemic stroke, including 128 patients with previous ischemic stroke and 32 patients with new-onset ischemic stroke during their hospitalizations. Compared with patients with cirrhosis without ischemic stroke, those with ischemic stroke were significantly older; had a significantly higher proportion of arterial hy- pertension and a significantly lower proportion of hepatitis B virus infection; had significantly higher white blood cell, platelet, blood urea nitrogen, and triglyceride levels; and had significantly lower alanine aminotransferase and aspartate aminotransferase levels and prothrombin time. The in-hospital mortality was significantly higher in patients with ischemic stroke than in those without [8.80% (14/160) vs. 3.2% (72/2284), P=0.001]. 269

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29264782 CONCLUSION: Ischemic stroke was often observed in patients with cirrho- PMID: 29288048 sis, and it significantly increased the in-hospital mortality. The association of inflammation, coagulation disorders, and viral hepatitis with development of ischemic stroke in liver cirrhosis should be further evaluated in prospective cohort studies. CITA: Eur J Gastroenterol Hepatol. 2018 Feb; 30(2):233-240 DOI: 10.1097/MEG.0000000000001011 TÍTULO: Differences in Body Composition in Patients with Obesity 1 Year After Roux-En-Y Gastric Bypass: Successful Vs. Unsuccessful Weight Loss AUTORES: Vázquez-Velázquez V, Rodríguez González A, Ordoñez Ortega S, Rodríguez Flores M, Herrera MF, Pantoja JP, Sierra M, González-Jáure- gui Prida C, García García JE. AIM: The aim of this study is to compare the differences in body composition inpatients with obesity with successful weight loss (SWL) and unsuccessful (USWL) 1 year after Roux-en-Y gastric bypass (RYGB). METHODS: We included 36 women and 22 men. After stratifying patients according with SWL (defined as ≥ 50% of excess weight loss), fat-free mass (FFM) and fat mass (FM) trajectories were analyzed in each group. RESULTS: The %FM in SWL women (78%) was lower than USWL (36 vs. 44, p < 0.001). The %FM in SWL men (77%) was lower than USWL (27 vs. 38, p < 0.05). A lower %FM before surgery increased the probability of suc- cess (p < 0.05). CONCLUSIONS: SWL patients have a lower %FM, and those with lower pre-surgical %FM are more likely to have SWL 1 year after RYGB. CITA: Obes Surg. 2018 Mar; 28(3):864-868. DOI: 10.1007/s11695-017-3059-x TÍTULO: Recommendations for the prevention and diagnosis of asthma in children: Evidence from international guidelines adapted for Mexico AUTORES: Larenas Linnemann DES, et al. BACKGROUND: With the availability of high-quality asthma guidelines worldwide, one possible approach of developing a valid guideline, with- out re-working the evidence, already analysed by major guidelines, is the ADAPTE approach, as was used for the development of National Guidelines on asthma. METHODS: The guidelines development group (GDG) covered a broad range of experts from medical specialities, primary care physicians and methodologists. The core group of the GDG searched the literature for asthma guidelines 2005 onward, and analysed the 11 best guidelines with AGREE-II to select three mother guidelines. Key clinical questions were for- mulated covering each step of the asthma management. RESULTS: The selected mother guidelines are British Thoracic Society (BTS), GINA and GEMA 2015. Responses to the questions were formulated according to the evidence in the mother guidelines. Recommendations or 270

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR suggestions were made for asthma treatment in Mexico by the core group, and adjusted during several rounds of a Delphi process, taking into account: 1. Evidence; 2. Safety; 3. Cost; 4. Patient preference - all these set against the background of the local reality. Here the detailed analysis of the evi- dence present in BTS/GINA/GEMA sections on prevention and diagnosis in paediatric asthma are presented for three age-groups: children with asthma ≤5 years, 6-11 years and ≥12 years. CONCLUSIONS: For the prevention and diagnosis sections, applying the AGREE-II method is useful to develop a scientifically-sustained document, ad- justed to the local reality per country, as is the Mexican Guideline on Asthma. CITA: Allergol Immunopathol (Madr). May-Jun 2018;46(3):291-303 DOI: 10.1016/j.aller.2017.05.011 PMID: 29311406 TÍTULO: The Changing Face of the Diagnosis of Chronic and Malignant Liv- er Diseases: Potential New Biomarkers AUTORES: Cruz-Ramón V, Chinchilla-López P, Ramírez-Pérez O, Qi X, Méndez-Sánchez N. SUMMARY: The early diagnosis of primary sclerosing cholangitis, hepato- cellular carcinoma, and cholangiocarcinoma is often challenging. In a recent study in 134 patients (Arbelaiz, Hepatology 2017; 66:1125-1143), it was re- ported that specific proteins found in serum extracellular vesicles of patients with primary sclerosing cholangitis, hepatocellular carcinoma, or cholangio- carcinoma may be useful as noninvasive diagnostic and prognostic tools. This current article critically appraises this study. CITA: Ann Hepatol. 2018 January-February; 17(1):14-17 DOI: 10.5604/01.3001.0010.7531 PMID: 29322967 TÍTULO: Alternative bibliometrics from the web of knowledge surpasses the impact factor in a 2-year ahead annual citation calculation: Linear mixed-de- sign models' analysis of neuroscience journals AUTORES: Diaz-Ruiz A, Orbe-Arteaga U, Rios C, Roldan-Valadez E. CONTEXT: The decision about which journal to choose for the publication of research deserves further investigation. AIMS: In this study, we evaluate the predictive ability of seven bibliometrics in the Web of Knowledge to calculate total cites over a 7-year period in neu- roscience journals. SETTINGS AND DESIGN: Coincidental bibliometrics appearing during 2007, 2008, 2009, 2010, and 2011, along with their corresponding cites in 2009, 2010, 2011, 2012, and 2013, were recorded from the journal citation reports (JCR) Science Edition. This was a retrospective study. MATERIALS AND METHODS: This was a bibliographic research using data from the Web of Knowledge in the neuroscience category. STATISTICAL ANALYSIS USED: A linear-mixed effects design using ran- dom slopes and intercepts was performed on 275 journals in the neurosci- ence category. 271

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29323538 RESULTS: We found that Eigen factor score, cited half-life, immediacy in- PMID: 29336054 dex, and number of articles are significant predictors of 2-year-ahead total cites (P ≤0.010 for all variables). The impact factor, 5-year impact factor, and article influence score were not significant predictors; the global effect size was significant (R2= 0.999; P < 0.001) with a total variance of 99.9%. CONCLUSIONS: An integrative model using a set of several metrics could represent a new standard to assess the influence and importance of scientif- ic journals, and may simultaneously help researchers to rank journals in their decision-making during the manuscript submission phase. CITA: Neurol India. 2018 Jan-Feb; 66(1):96-104 DOI: 10.4103/0028-3886.222880 TÍTULO: Clinical characteristics and outcomes of traditional Chinese medi- cine-induced liver injury: a systematic review AUTORES: Wang R, Qi X, Yoshida EM, Méndez-Sánchez N, Teschke R, Sun M, Liu X, Su C, Deng J, Deng H, Hou F, Guo X. BACKGROUNDS: Traditional Chinese medicine (TCM) is becoming increas- ingly popular and related adverse events are often ignored or underestimated. AIMS: This systematic review aimed to evaluate the clinical characteristics and outcomes of TCM-induced liver injury (TCM-ILI) and to estimate the pro- portion of TCM-ILI in all drug-induced liver injuries (DILI). METHODS: China National Knowledge Infrastructure, Wanfang, VIP, PubMed, and Embase databases were searched. Demographic, clinical, and survival data were extracted and pooled. Factors associated with worse outcomes were calculated. For the proportion meta-analyses, the data were pooled by using a random-effects model. RESULTS: Overall, 21,027 articles were retrieved, of which 625 were finally included. There was a predominance of female and older patients. The pro- portion of liver transplantation was 2.18% (7/321). The mortality was 4.67% (15/321). Male, higher aspartate aminotransferase and direct bilirubin, and lower albumin were significantly associated with an increased risk of death/ liver transplantation in TCM-ILI patients. The proportion of TCM-ILI in all DILI was25.71%. The proportion was gradually increased with year. CONCLUSIONS: Our work summarizes current knowledge regarding clini- cal presentation, disease course, and prognosis of TCM-ILI. TCM can result in hepatotoxicity, even death or necessitate life-saving liver transplantation. Governmental regulation of TCM products should be strictly established. CITA: Expert Rev Gastroenterol Hepatol. 2018 Apr;12(4):425-434 DOI: 10.1080/17474124.2018.1427581 TÍTULO: The EAACI/GA²LEN/EDF/WAO guideline for the definition, classifi- cation, diagnosis and management of urticaria AUTORES: Zuberbier T, (…) Larenas-Linnemann D, et al. ABSTRACT: This evidence- and consensus-based guideline was devel- oped following the methods recommended by Cochrane and the Grading 272

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR of Recommendations Assessment, Development and Evaluation (GRADE) working group. The conference was held on 1December 2016. It is a joint initiative of the Dermatology Section of the European Academy of Allergolo- gy and Clinical Immunology (EAACI), the EU-founded network of excellence, the Global Allergy and Asthma European Network (GA²LEN), the European Dermatology Forum (EDF) and the World Allergy Organization (WAO) with the participation of 48 delegates of 42 national and international societies. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell-driven disease, presenting with wheals, angioedema, or both. The lifetime prevalence for acute urticaria is approximately 20%. Chronic spontaneous urticaria and oth- er chronic forms of urticaria are disabling, impair quality of life and affect performance at work and school. This guideline covers the definition and classification of urticaria, taking into account the recent progress in identify- ing its causes, eliciting factors and pathomechanisms. In addition, it outlines evidence-based diagnostic and therapeutic approaches for the different sub- types of urticaria. CITA: Allergy. 2018 Jul; 73(7):1393-1414 DOI: 10.1111/all.13397 PMID: 29336067 TÍTULO: Treatment of allergic rhinitis using mobile technology with re- al-world data: The MASK observational pilot study AUTORES: Bousquet J, (...) Larenas-Linnemann D, Laune et al. BACKGROUND: Large observational implementation studies are needed to triangulate the findings from randomized control trials as they reflect \"re- al-world\" everyday practice. In a pilot study, we attempted to provide addi- tional and complementary insights on the real-life treatment of allergic rhini- tis (AR) using mobile technology. METHODS: A mobile phone app (Allergy Diary, freely available in Google Play and Apple App stores) collects the data of daily visual analog scales (VAS) for (i) overall allergic symptoms, (ii) nasal, ocular, and asthma symp- toms, (iii) work, as well as (iv) medication use using a treatment scroll list including all medications (prescribed and over the counter (OTC)) for rhinitis customized for15 countries. RESULTS: A total of 2871 users filled in 17 091 days of VAS in 2015 and 2016. Medications were reported for 9634 days. The assessment of days ap- peared to be more informative than the course of the treatment as, in real life, patients do not necessarily use treatment on a daily basis; rather, they ap- pear to increase treatment use with the loss of symptom control. The Allergy Diary allowed differentiation between treatments within or between classes (intranasal corticosteroid use containing medications and oral H1-antihista- mines). The control of days differed between no [best control], single, or mul- tiple treatments (worst control). CONCLUSIONS: This study confirms the usefulness of the Allergy Diary in accessing and assessing everyday use and practice in AR. This pilot ob- servational study uses a very simple assessment (VAS) on a mobile phone, shows novel findings, and generates new hypotheses. CITA: Allergy. 2018 Sep; 73(9):1763-1774 DOI: 10.1111/all.13406 273

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29438602 TÍTULO: International Consensus Statement on Allergy and Rhinology: Al- PMID: 29456415 lergic Rhinitis AUTORES: Wise SK, (…) Larenas-Linnemann D, et al. BACKGROUND: Critical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR: AR). METHODS: Using previously described methodology, specific topics were developed relating to AR. Each topic was assigned a literature review, ev- idence-based review (EBR), or evidence-based review with recommenda- tions (EBRR) format as dictated by available evidence and purpose within the ICAR: AR document. Following iterative reviews of each topic, the ICAR: AR document was synthesized and reviewed by all authors for consensus. RESULTS: The ICAR: AR document addresses over 100 individual topics related to AR, including diagnosis, pathophysiology, epidemiology, disease burden, risk factors for the development of AR, allergy testing modalities, treatment, and other conditions/comorbidities associated with AR. CONCLUSION: This critical review of the AR literature has identified several strengths; providers can be confident that treatment decisions are supported by rigorous studies. However, there are also substantial gaps in the AR liter- ature. These knowledge gaps should be viewed as opportunities for improve- ment, as often the things that we teach and the medicine that we practice are not based on the best quality evidence. This document aims to highlight the strengths and weaknesses of the AR literature to identify areas for future AR research and improved understanding. CITA: Int Forum Allergy Rhinol. 2018 Feb; 8(2):108-352 DOI: 10.1002/alr.22073 TÍTULO: Gastroenteritis in an adult female revealing hemolytic uremic syn- drome: Case report AUTORES: Chinchilla-López P, Cruz-Ramón V, Ramírez-Pérez O, Mén- dez-Sánchez N. SUMMARY: Nowadays acute gastroenteritis infection caused by Escherich- ia coli (E. coli) O157:H7 is frequently associated with hemolytic uremic syn- drome (HUS), which usually developed after prodromal diarrhea that is often bloody. The abdominal pain accompanied by failure kidney is a suspicious symptom to develop this disorder. Their pathological characteristic is vascu- lar damage which manifested as arteriolar and capillary thrombosis with ab- normalities in the endothelium and vessel walls. The major etiological agent of HUS is entero hemorragic (E coli) strain belonging to serotype O157:H7. The lack of papers about HUS associated to gastroenteritis lead us to report this case for explain the symptoms that are uncommon. Furthermore, this report provides some strategies to suspect and make an early diagnosis, be- sides treatment approach to improving outcomes and prognosis for patients with this disorder. CITA: World J Gastroenterol. 2018 Feb 14; 24(6):763-766 DOI: 10.3748/wjg.v24.i6.763 274

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29469042 TÍTULO: More Evidence for the Genetic Susceptibility of Mexican Popula- tion to Nonalcoholic Fatty Liver Disease through PNPLA3 AUTORES: Chinchilla-López P, Ramírez-Pérez O, Cruz-Ramón V, Cani- zales-Quinteros S, Domínguez-López A, Ponciano-Rodríguez G, Sánchez- -Muñoz F, Méndez-Sánchez N. BACKGROUND: The gene for patatin-like phospholipase domain contain- ing 3 (PNPLA3) is associated with nonalcoholic fatty liver disease (NAFLD) development. We previously found that Mexican indigenous population had the highest frequency reported of the PNPLA3 148M risk allele. Further, we observed a relationship between M148M genotype with elevated ALT lev- els in individuals with normal weight, overweight and obese. We sought to investigate whether PNPLA3polymorphism is associated with NAFLD devel- opment in Mexicans. MATERIAL AND METHODS: We enrolled 189 Mexican patients with NA- FLD and 201 healthy controls. Anthropometric, metabolic, and biochemical variables were measured, andrs738409 (Ile148Met substitution) polymor- phism was genotyped by sequencing. RESULTS: Logistic regression analysis, using a recessive model, suggest- ed thatPNPLA3 polymorphism in Mexican population is significantly associ- ated (OR =1.711, 95% CI: 1.014-2.886; P = 0.044) with NAFLD. CONCLUSIONS: The PNPLA3 gene is associated with NAFLD in Mexican population. More studies are required to explain the high prevalence of PNPLA3 polymorphism in Mexican-Americans, Mexican-Indians, and Mex- ican-Mestizos. CITA: Ann Hepatol. 2018 Mar 1; 17(2):250-255 DOI: 10.5604/01.3001.0010.8644 PMID: 29508240 TÍTULO: Eigen factor score and alternative bibliometrics surpass the im- pact factor in a 2-years ahead annual-citation calculation: a linear mixed design model analysis of Radiology, Nuclear Medicine and Medical Imag- ing journals AUTORES: Roldan-Valadez E, Orbe-Arteaga U, Rios C. INTRODUCTION: Because we believe the journal selection before a man- uscript submission deserves further investigation in each medical special- ty, we aimed to evaluate the predictive ability of seven bibliometrics in the Radiology, Nuclear Medicine and Medical Imaging category of the Web of Knowledge to calculate total citations over a 7-year period. METHODS: A linear mixed effects design using random slopes and inter- cepts were performed on bibliometrics corresponding to 124 journals from 2007 to 2011, with their corresponding citations from 2009 to 2013, which appeared in the Journal Citations Report Science Edition. RESULTS: The Eigen factor Score, Article Influence Score, Cited Half-life, 5-yearsimpact factor and Number of Articles are significant predictors of 2-year-aheadtotal citations (p ≤ 0.010 for all variables). The impact factor and Immediacy Index are not significant predictors. There was a significant global effect size (R2 = 0.934; p < 0.001), which yielded a total variance of 93.4%. 275

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29517800 CONCLUSIONS: Our findings support researchers' decision to stop the PMID: 29529256 misuse of IF alone to evaluate journals. Radiologists and other research- ers should review journal's bibliometrics for their decision-making during the manuscript submission phase. A re-ranking of journals using Eigen factor Score, Article Influence Score, and Cited Half-life provides a better assess- ment of their significance and importance in particular disciplines. CITA: Radiol Med. 2018 Jul; 123(7):524-534 DOI: 10.1007/s11547-018-0870-y TÍTULO: Chronic urticaria can be caused by cancer and resolves with its cure AUTORES: Larenas-Linnemann D, Saini SS, Azamar-Jácome AA, Maurer M. ABSTRACT: Case report CITA: Allergy. 2018 Jul; 73(7):1562-1566 DOI: 10.1111/all.13434 TÍTULO: Clinical and echocardiographic factors associated with mitral plas- ticity in patients with chronic inferior myocardial infarction AUTORES: Ávila-Vanzzini N, Michelena HI, Fritche Salazar JF, Herre- ra-Bello H, Siu Moguel S, Rodríguez Ocampo RR, Oregel Camacho DJ, Es- pínola Zavaleta N. AIMS: Ischaemic mitral regurgitation (IMR) is consequence of left ventric- ular (LV) remodelling after myocardial infarction. In some cases, the mitral valve enlarges to compensate for LV remodelling and tenting, improving its coaptation; a process termed 'plasticity'. We sought to identify clinical and echocardiographic factors associated with plasticity in patients with chronic inferior myocardial infarction (CII). METHODS AND RESULTS: This study included 91 revascularized CII patients and 46 controls. Plasticity and IMR severity were evaluated by 2D transthoracic echocardiography. Compared with controls, CII patients were older (59 vs. 25 years) and mostly men (80% vs. 46%), both P < 0.001. Chronic inferior myocardial infarction patients also had significant LV re- modelling: larger LV volumes, larger mitral tenting areas, larger coaptation depths, longer mitralle aflets and chords, and worse mitral regurgitation (all P ≤ 0.03). Of 91 CII patients, 60 had mitral plasticity (longer anterior and pos- terior leaflets and longer posterior chords, all P < 0.001), despite not exhib- iting significantly larger LV volumes, tenting area or coaptation depth, when compared with patients with no plasticity. Contralateral (anterior) papillary muscle-to-annulus length tended to be increased in CII plasticity patients (P = 0.05). Also they had less moderate and severe IMR (both P < 0.04) com- pared with non-plasticity CII patients. Multivariate analysis demonstrated independent associations between plasticity and smoking [odds ratio (OR) 0.03, 0.002-0.57; P = 0.019], duration oftype-2 diabetes (OR 1.19, 1.007- 1.42; P = 0.04) and haemoglobin (OR 2.17, 1.25-3.76; P = 0.005). CONCLUSION: Mitral plasticity results in less moderate and severe IMR. Longer time-duration of diabetes mellitus and higher haemoglobin level are independently associated with mitral plasticity, while smoking independently associates with no plasticity. Increased anterior papillary muscle-to-annulus length in CII patients with plasticity suggests complex LV remodelling mech- anisms are involved in plasticity. 276

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR CITA: Eur Heart J Cardiovasc Imaging. 2018 May 1; 19(5):508-515 DOI: 10.1093/ehjci/jey021 PMID: 29549356 TÍTULO: The management of incidental fatty liver found on imaging. What PMID: 29551403 do we need to do? AUTORES: Méndez-Sánchez N, Chavez-Tapia NC, Almeda-Valdes P, Uribe M. SUMMARY: Editorial CITA: Am J Gastroenterol. 2018 Sep; 113(9):1274-1276 DOI: 10.1038/s41395-018-0047-2 TÍTULO: Pediatric asthma treatment: What to do when international guide- line recommendations do not agree AUTORES: Larenas Linnemann DES, et al.. BACKGROUND: There was a need for a solid asthma guideline in Mexi- co to update and unify asthma management. Because high-quality asthma guidelines exist worldwide, in which the latest evidence on asthma manage- ment is summarized, the ADAPTE approach allows for the development of a national asthma guideline based on evidence from already existing guide- lines, adapted to national needs. OBJECTIVE: To fuse evidence from the best asthma guidelines and adapt it to local needs with the ADAPTE approach. METHODS: The Appraisal of Guidelines for Research and Evaluation (AGREE) II asthma guidelines were evaluated by a core group to select 3 primary guidelines. For each step of asthma management, clinical ques- tions were formulated and replied according to (1) evidence in the primary guidelines, (2) safety, (3) Cost, and (4) patient preference. The Guidelines Development Group, composed of a broad range of experts from medical specialties, primary care physicians, and methodologists, adjusted the draft questions and replies in several rounds of a Delphi process and 3 face-to- face meetings, taking into account the reality of the situation in Mexico. We present the results of the pediatric asthma treatment part. RESULTS: Selected primary guidelines are from the British Thoracic So- ciety and Scottish Intercollegiate Guidelines Network (BTS/SIGN), Global Initiative for Asthma (GINA), and Spanish Guidelines on the Management of Asthma (GEMA) 2015, with 2016 updates. Recommendations or sugges- tions were made for asthma treatment in Mexico. In this article, the detailed analysis of the evidence present in the BTS/SIGN, GINA, and GEMA sec- tions on the (non) pharmacologic treatment of pediatric asthma, education, and devices are presented for 2 age groups: children5 years or younger and children 6 to 11 years old with asthma. CONCLUSION: For the pediatric treatment and patient education sections, applying the AGREE II and Delphi methods is useful to develop a scientifical- ly sustained document, adjusted to the Mexican situation, as is the Mexican Guideline on Asthma. CITA: Ann Allergy Asthma Immunol. 2018 Jul; 121(1):7-13.e4 DOI: 10.1016/j.anai.2018.03.008 277

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29569295 TÍTULO: Daily allergic multimorbidity in rhinitis using mobile technology: A PMID: 29587223 novel concept of the MASK study AUTORES: Bousquet J, (…) Larenas-Linnemann D, et al. BACKGROUND: Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary. METHODS: We undertook a 1-year prospective observational study in which 4 210users and 32 585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale lev- els <20/100 were categorized as \"Low\" burden and VAS levels ≥50/100 as \"High\" burden. RESULTS: Visual analogue scales global measured levels assessing the global control of the allergic disease were significantly associated with al- lergic multimorbidity. Eight hypothesis-driven patterns were defined based on \"Low\" and \"High\" VAS levels. There were <0.2% days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9% days with a Rhinitis High-Asthma Low pattern. There were 1.7% days with a Rhinitis High-Asthma High-Conjunctivitis Low pattern. A novel Rhinitis High-Asthma High-Conjunctivitis High pattern was identified in 2.9% days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels. CONCLUSIONS: In a novel approach examining daily symptoms with mo- bile technology, we found considerable intra-individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of un- controlled multimorbidity. CITA: Allergy. 2018 Aug; 73(8):1622-1631 DOI: 10.1111/all.13448 TÍTULO: Hallmarks of Alzheimer disease are evolving relentlessly in Metro- politan Mexico City infants, children and young adults. APOE4 carriers have higher suicide risk and higher odds of reaching NFT stage V at ≤ 40 years of age AUTORES: Calderón-Garcidueñas L, Gónzalez-Maciel A, Reynoso-Robles R, Delgado-Chávez R, Mukherjee PS, Kulesza RJ, Torres-Jardón R, Ávila- Ramírez J, Villarreal-Ríos R. SUMMARY: Exposures to fine particulate matter (PM2.5) and ozone (O3) above USEPA standards are associated with Alzheimer's disease (AD) risk. Metropolitan Mexico City (MMC) residents have life time exposures to PM2.5 and O3 above USEPA standards. We investigated AD intra and extracellular protein aggregates and ultrastructural neurovascular pathology in 203 MMC residents age 25.36 ± 9.23 y. Immunohistochemical methods were used to identify AT8 hyperphosphorilated tau (Htau) and 4G8 (amyloid β 17-24). Pri- mary outcomes: staging of H tau and amyloid, per decade and cumulative PM2.5 (CPM2.5) above standard. Apolipoprotein E allele 4 (APOE4), age and cause of death were secondary outcomes. Subcortical pret angle stage 278

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR b was identified in an 11month old baby. Cortical tau pre-tangles, neurofibril- lary tangles (NFT) Stages I-II, amyloid phases 1-2, Htau in substantian igrae, auditory, oculomotor, trigeminal and autonomic systems were identified by the 2nd decade. Progression to NFT stages III-V was present in 24.8% of 30-40 y old subjects. APOE4 carriers have 4.92 times higher suicide odds (p = 0.0006), and 23.6 times higher odds of NFT V (p < 0.0001) v APOE4 non-carriers having similar CPM2.5 exposure and age. Age (p = 0.0062) and CPM2.5 (p = 0.0178) were significant for developing NFT V. Combustion-de- rived nanoparticles were associated with early and progressive damage to the neurovascular unit. Alzheimer's disease starting in the brainstem of young children and affecting99.5% of young urbanites is a serious health crisis. Air pollution control should be prioritized. Childhood relentless Htau makes a fundamental target for neuroprotective interventions and the first two decades are critical. Were commend the concept of preclinical AD be revised and emphasize the need to define pediatric environmental, nutrition- al, metabolic and genetic risk factor interactions of paramount importance to prevent AD. AD evolving from childhood is threating the wellbeing of our children and future generations. CITA: Environ Res. 2018 Jul;164:475-487 DOI: 10.1016/j.envres.2018.03.023 PMID: 29606490 TÍTULO: Stress induced cardiomyopathy due to a Mexican earthquake PMID: 29629956 AUTORES: Fernández-Ferreira R, Morales-Victorino N, Herrera-Go- mar M, Alcántara-Meléndez MA, García-Graullera M, González-Chon O, García-López SM. SUMMARY: Takotsubo Cardiomyopathy mainly occurs in postmenopausal women, with or without cardiovascular disease, and is commonly associated with emotional or physical stress. After nearly 27 years of extensive efforts towards a better understanding of this disorder, current knowledge remains limited. Many people suffer post-traumatic stress, and this situation can be associated to stress cardiomyopathy. The case is presented of a female who suffers stress associated with the earthquake of 19 September 2017 in Mex- ico City, and arrived in the Emergency Department in cardiogenic shock. CITA: Arch Cardiol Mex. 2018 Jul - Sep; 88(3):219-224 DOI: 10.1016/j.acmx.2018.02.008 TÍTULO: What you should not miss from the systematic reviews and me- ta-analyses on allergen-specific immunotherapy in 2017 AUTORES: Larenas-Linnemann D, Luna-Pech JA. PURPOSE OF REVIEW: Allergen immunotherapy (AIT) is a well recognized and extensively studied therapeutic intervention for some allergic diseases. Every year new systematic reviews and meta-analysis provide the most powerful source of evidence to orient decision making on prevention or effi- cacy of AIT. We here discuss systematic reviews and meta-analyses on AIT (published January 2017 to February 2018). RECENT FINDINGS: We identified 4 systematic reviews and 10 meta-analy- ses. Subcutaneous and sublingual AIT (SCIT/SLIT) significantly reduced the development of asthma in children-adolescents with moderate/severe aller- 279

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29653359 gic rhinitis, but evidence for a short-term, preventive effect for new allergic sensitizations was nonconclusive. SCIT/SLIT proved to significantly improve symptom and medication scores versus placebo or active comparators in re- spiratory allergy, with various effect sizes. Oral immunotherapy for IgE-medi- ated food allergy resulted insubstantial benefit in desensitization rates. Data on venom AIT and latex AIT, although limited in quantity and quality, respec- tively, suggest a large and discrete beneficial effect. SUMMARY: Although current evidence extracted from meta-analyses and systematic reviews support AIT as an effective, relatively safe, and well toler- ated alternative for some allergic diseases, heterogeneity and some method- ological inconsistencies represent matters of concern as they may affect the validity and applicability of their results, especially in the context of individual, real-life settings. CITA: Curr Opin Allergy Clin Immunol. 2018 Jun; 18(3):168-176 DOI: 10.1097/ACI.0000000000000439 TÍTULO: The role of the gut microbiota in the pathology and prevention of liver diseas AUTORES: Altamirano-Barrera A, Uribe M, Chávez-Tapia NC, Nuño-Lám- barri N. SUMMARY: Several microorganisms belonging to the intestinal microbiota act in an ecosystem responsible for maintaining the homeostasis and vital functions of human beings. From birth to old age the diversity of the intes- tinal microbiota may change due to environmental factors such as nutrition, immunity, diseases or the use of antibiotics leading to dysbiosis. Improve- ment in microbiota diversity can be achieved by modifying related risk fac- tors through changes in lifestyle and a healthy diet. Besides, the addition of probiotics, prebiotics or the combination of both (symbiotics), can result in the improvement of the intestinal permeability, inflammatory pathways and the immune system. Also, the use of probiotics prevents harmful bacteria and their derived products (e.g., bacteriocins, endotoxins, hydrogen sulfide, etc.) to leak through the intestinal wall to the circulation that results in the activation of signaling pathways that may be implicated in liver disease. The liver receives a constant flow of noxious entities that promote inflammation and oxidative stress. The use of probiotics with clinical evidence in liver dis- ease, represent a novel therapeutic alternative, inducing positive changes in the balance of the intestinal microbiota which lead to improvement in liver function tests (AST and ALT), decreasing tumor necrosis factor-α (TNF-α), and blood cholesterol, among other risk factors. In this review, we discuss the main elements that play a leading role in the development of steatosis as well as the benefits of using probiotics and the impact in the quality of life of patients that develop cirrhosis. CITA: J Nutr Biochem. 2018 Oct; 60:1-8 DOI: 10.1016/j.jnutbio.2018.03.006 PMID: 29660603 TÍTULO: Both alcoholic and non-alcoholic steatohepatitis association with cardiovascular risk and liver fibrosis AUTORES: Sánchez-Jiménez BA, Brizuela-Alcántara D, Ramos-Ostos MH, Alva-López LF, Uribe-Esquivel M, Chávez-Tapia NC. 280

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29662860 BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most com- mon cause of liver disease worldwide. Mortality in NAFLD is mainly related to cardiovascular disease (CVD) and cancer. NAFLD and its association with both CVD and liver disease risk have been well evaluated, but the as- sociation of NAFLD with alcohol, known as \"both alcoholic and non-alcoholic steatohepatitis\" (BASH), remains uncertain. The objective of this study was to assess the influence of alcohol and obesity in the development of liver and cardiovascular disease risk. METHODS: This was a case-control study that included patients from a reg- ular check-up. Alcohol consumption was evaluated with MAST, AUDIT, and CAGE. Cardiovascular risk was evaluated using the Framingham score, and liver fibrosis was evaluated with APRI and NAFLD score. Patients were clas- sified in five groups: healthy patients, steatosis with obesity, steatosis with alcoholism, BASH, and idiopathic steatosis. RESULTS: A total of 414 patients were included. The BASH group repre- sented 16% of patients, and showed a greater proportion of patients with high cardiovascular risk with 17% (p = 0.001), and liver fibrosis with 9%, according to the APRI score (p = 0.10). A multivariate logistic regression showed that alcohol consumption >140 g/week (OR 2.546, 95% CI 1.11- 5.81, p = 0.003) and BMI >25 kg/m2 (OR 12.64, 95% CI 1.66 96.20, p = 0.001) were related to high cardiovascular risk. Liver fibrosis according to APRI was only related to alcohol consumption>140 g/week (OR 2.74, 95% CI 1-7.48, p = 0.03). CONCLUSIONS: BASH remains an area not well explored, and of great im- plication given the increasing number of patients affected. We observed an additive effect of both etiologies in the development of high cardiovascular and liver disease risk. CITA: Alcohol. 2018 Jun; 69:63-67 DOI: 10.1016/j.alcohol.2017.11.004 TÍTULO: Splenic myeloid metaplasia in warm autoimmune hemolytic anemia (wAIHA): a retrospective study AUTORES: Anguiano-Álvarez VM, Hernández-Company A, Hamdan-Pérez N, Montante-M D, Zúñiga-Tamayo DA, Rodríguez-Rodríguez S, Pomerantz A, Tuna-Aguilar EJ. BACKGROUND: Splenic myeloid metaplasia (SMM) is a kind of extramed- ullary hematopoiesis, whereas its clinical significance in wAIHA remains un- clear. The aim of this study is evaluating the frequency and clinical charac- teristics of SMM, compared with splenic-congestion (SC). METHODS: We included patients with wAIHA treated in a Mexican tertiary hospital between January 1992 and December 2015. All patients received steroids as first-line treatment and splenectomy as second-line treatment. RESULTS: Among the thirty-six splenectomized patients, 15 (41.6%) and 21 (58.4%) were diagnosed as SMM and SC, respectively. No differences were found in clinical characteristics between two groups. SMM patients showed lower platelet count (147×109/L vs. 240×109/L, P=0.02) and high- er presence of anti-dsDNA antibodies (40% vs. 4.7%, P=0.01) than SC pa- tients. Although the complete response (CR) rate with first-line treatment was lower in SMM patients (13.3% vs. 47.6%; P=0.04), post-splenectomy 281

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR median disease-free-survival (DFS) was longer (16.2 mo vs. 5.1mo; P=0.19). Univariate/multivariate analysis showed that achieving CR during first-line treatment (OR 0.3, 95% CI: 0.03-0.94, P=0.03) and higher platelet count (OR 0.99, 95% CI: 0.98-0.99, P=0.03) were protective factors for SMM; and anti-dsDNA titer higher than 9.6 IU/dL was a risk factor for SMM (OR 2.76, 95%CI: 1.48-5.14, P<0.001). CONCLUSION: The wAIHA patients with SMM have different biological profiles with those without SMM. This study is the first trial evaluating the significance of histopathological spleen findings and their association with rheumatologic profile. CITA: Blood Res. 2018 Mar;53(1):35-40 DOI: 10.5045/br.2018.53.1.35 PMID: 29673731 TÍTULO: Duplication of SOX9 associated with 46,XX ovotesticular disorder PMID: 29681771 of sex development AUTORES: López-Hernández B, Méndez JP, Coral-Vázquez RM, Bení- tez-Granados J, Zenteno JC, Villegas-Ruiz V, Calzada-León R, Soderlund D, Canto P. RESEARCH QUESTION: The purpose of the present study was to investigate whether ten unrelated SRY-negative individuals with this sex differentiation disorder presented a double dose of SOX9 as the cause of their disease. DESIGN: Ten unrelated SRY-negative 46,XX ovo testicular disorder of sex- ual development (DSD) subjects were molecularly studied. Multiplex-ligation dependent probe amplification (MLPA) and quantitative real-time PCR analy- sis (qRT-PCR) for SOX9 were performed. RESULTS: The MLPA analysis demonstrated that one patient presented a heterozygous duplication of the entire SOX9 coding region (above 1.3 value of peak ratio), as well as at least a ~ 483 kb upstream duplication. Moreover, no duplication of other SOX9 probes was observed corresponding to the region between -1007 and-1500 kb upstream. A qRT-PCR analysis showed a duplication of at least -581 kbup stream and ~1.63 kb of the coding region that encompasses exon 3. The limits of the duplication were mapped ap- proximately from ~71539762 to 72122741 of Chr17. No molecular abnormal- ities were found in the remaining nine patients. CONCLUSION: This study is thought to be the first report regarding a dupli- cation of SOX9 that is associated with the presence of 46,XX ovo testicular DSD, encompassing at least -581 kb upstream, and the almost entire coding region of the gene. CITA: Reprod Biomed Online. 2018 Jul; 37(1):107-112 DOI: 10.1016/j.rbmo.2018.03.017 TÍTULO: Dosimetry of the left anterior descending coronary artery in left breast cancer patients treated with postoperative external radiotherapy AUTORES: Poitevin-Chacón A, Chávez-Nogueda J, Prudencio RR, Fernández AC, Laguna AR, Linares J, Martínez JC. 282

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR AIM: To evaluate the dose distribution to the left anterior descending (LAD) coronary artery in patients treated with postoperative three-dimensional con- formal radiotherapy (3DCRT). BACKGROUND: Postoperative radiotherapy may increase the risk of heart disease, particularly in patients with left-sided breast cancer. Clinical data on doses to the LAD are limited. MATERIALS AND METHODS: Retrospective study of 14 patients who un- derwent postoperative 3DCRT for left breast cancer in 2014. All data were retrieved from medical records. Means, medians, ranges, and percentages were calculated. RESULTS: The mean dose to the LAD in patients with V25 < 1% was 0.12 cGy. Dmean, Dmax and V25 to the heart were, respectively, 3.7 Gy (range, 0.9-4.18), 40.3 Gy (9.28-62.9), and 1.59 cGy. The mean Dmean and Dmax values in the sample were9.71 Gy and 33.2 Gy, respectively. The maximum dose to the LAD (D2%) ranged from 3.66 to 53.01 Gy. Due to the spacing of the CT slices (5 mm), it was not possible to completely contour the entire artery. The mean dose to the heart (3.3 Gy) was considered acceptable. CONCLUSIONS: The maximum dose to the LAD was as high as 53 Gy, sug- gesting an increased risk of cardiac morbidity. This study underscores the value of contouring the LAD and the value of the breath hold technique to reduce maximum cardiac doses. Smaller CT cuts (2.5 mm) can improve con- touring. Larger studies with long-term follow up are needed to determine the radiation tolerance dose for the LAD. CITA: Rep Pract Oncol Radiother. 2018 Mar-Apr; 23(2):91-96 DOI: 10.1016/j.rpor.2018.01.003 PMID: 29683962 TÍTULO: Pulmonary Ultrasound: A New Era in Critical Care Medicine PMID: 29685744 AUTORES: Ñamendys-Silva SA, Garrido-Aguirre E, Romero-González JP, Mena-Arceo RG, Rojo Del Moral O, González-Chon O. SUMMARY: Pulmonary ultrasonography is a complementary study that is easy to perform at the patient bedside with no need to transfer the patient to special areas. The technique provides information with high sensitivity and specificity for different pathologies. Pulmonary ultrasonography is a very im- portant diagnostic tool in the assessment of lung, pleural, and chest wall diseases. Pulmonary ultrasound provides low-cost analysis, easy real-time reproduction, and safety, all of which have made it a beneficial tool in the di- agnostic arsenal available to medical personnel. The purpose of this review was to describe the usefulness of pulmonary ultrasound in critical areas. CITA: Ultrasound Q. 2018 Dec; 34(4):219-225 DOI: 10.1097/RUQ.0000000000000357 TÍTULO: Update on biosimilars in inflammatory bowel disease: Position and recommendations in Mexico AUTORES: Mayoral-Zavala A, Esquivel-Aguilar A, Del Real-Calzada CM, Gutiérrez-Grobe Y, Ramos-García J, Rocha-Ramírez JL, Rojas-Illanes MF, Rubio-Martínez B, Sánchez-Chávez X, Yamamoto-Furusho JK 283

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29707877 SUMMARY: The biotechnology-derived medicines known as biosimilars are PMID: 29725538 defined as non-originator treatments that have demonstrated quality, effi- cacy, and safety comparable to the reference biologic drug. Clinical trials have shown that the infliximab biosimilar, CT-P13, and the candidates for the adalimumab biosimilars, ABP 501 and ZRC 3197, are not significant- ly different, with respect to efficacy and safety, from the originator drugs in patients with other autoimmune diseases. However, controversy has arisen over the use of biosimilars in inflammatory bowel disease, due to the incip- ient evidence not only in patients with no previous biotechnology treatment, but also in patients in remission, that could be switched to a biosimilar for non-medical reasons. The present review is the first critical analysis by dif- ferent specialists in the area of gastroenterology on the use of biosimilars in inflammatory bowel disease, the evidence on interchangeability, and the extrapolation of indications, efficacy, safety, immunogenicity, and the clinical impact of the Mexican health regulations. The aim of our review was to make the positioning and recommendations of these new therapeutic options known, given that they have a potential cost-benefit for both patients and healthcare institutions. CITA: Rev Gastroenterol Mex. 2018 Oct - Dec; 83(4):414-423 DOI: 10.1016/j.rgmx.2018.03.003 TÍTULO: Evidence-based treatment for gynoid lipodystrophy: A review of the recent literature AUTORES: Pérez Atamoros FM, Alcalá Pérez D, Asz Sigall D, Ávila Romay AA, Barba Gastelum JA, de la Peña Salcedo JA, Escalante Salgado PE, Gal- lardo Palacios GJ, Guerrero-Gonzalez GA, Morales De la Cerda R, Ponce Oli- vera RM, Rossano Soriano F, Solís Tinoco E, Welsh Hernández EC. SUMMARY: Gynoid lipodystrophy (GLD) is a structural, inflammatory, and biochemical disorder of the subcutaneous tissue causing alterations in the topography of the skin. Commonly known as \"cellulite,\" GLD affects up to 90% of women, practically in all stages of the life cycle, beginning in puberty. It is a clinical condition that considerably affects the patients' quality of life. It is a frequent reason for consultation, although the patients resort to empir- ical, improvised, nonevidence-based treatments which discourage and can be a source of frustration not only because of the lack of results but also due to the complications derived from those treatments. In this article, a panel of experts from different specialties involved in the management of this clinical skin disorder presents the results of a systematic literature search and of the consensus discussion of the evidence obtained from different treatments currently available. The analysis was divided into topical, systemic, noninva- sive, and minimally invasive treatments. CITA: J Cosmet Dermatol. 2018 Dec; 17(6):977-983 DOI: 10.1111/jocd.12555 TÍTULO: Appendiceal carcinoma associated with microsatellite instability AUTORES: Morales-Miranda A, Rosado ID, Núñez CC, Montero FC. SUMMARY: Approximately 15% of colorectal cancer (CRC) cases exhibit microsatellite instability (MSI), which appears to be associated with unique 284

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR biological behavior. The present study presents a case of appendiceal car- cinoma associated with MSI that responded well to adjuvant chemotherapy. Clinical, pathological and immunohistochemical (IHC) characteristics have been described. The 60-year-oldmale patient had suffered from recurrent lower abdominal pain associated with abdominal distention for 6 months; then, following an acute attack, he was subjected to laparoscopic appendec- tomy. The histopathological examination revealed moderately differentiated appendiceal adenocarcinoma with mucinous areas, without lympho vascular or perineural invasion. The IHC examination was positive for keratin-20 and caudal type homeobox 2, and negative for MutL Homolog1, MutS Homolog (MSH) 2 and MSH-6. A postoperative colonoscopy revealed diverticulosis, without the presence of polyps or tumors. However, an abdominal axial computerized tomography scan revealed thickening of the distal portion of the appendix, increased density of the greater omentum, and metastases to the liver capsule, spleen and peritoneum. The treatment of choice was right hemicolectomy with peritoneal debulking, followed by 10 cycles of che- motherapy with 5-fluorouracil, leucovorin and oxaliplatin (FOLFOX regimen). After 5 years of follow-up, the patient remains in good condition, without clin- ical or radiological signs of recurrence. The good response to chemotherapy corresponds with the observations made in other colon cancers with MSI. Therefore, testing for MSI in appendiceal carcinomas may provide useful in- formation on prognosis and predict response to chemotherapy. CITA: Mol Clin Oncol. 2018 May; 8(5):694-698 DOI: 10.3892/mco.2018.1596 PMID: 29733072 TÍTULO: [The importance of intra-hospital pharmacovigilance in the detec- tion of medication errors] AUTORES: Villegas F, Figueroa-Montero D, Barbero-Becerra V, Juárez-Hernández E, Uribe M, Chávez-Tapia N, González-Chon O. INTRODUCTION: Hospitalized patients are susceptible to medication errors, which represent between the fourth and the sixth cause of death. The de- partment of intra-hospital pharmacovigilance intervenes in the entire process of medication with the purpose to prevent, repair and assess damages. OBJECTIVE: To analyze medication errors reported by Mexican Fundación Clínica Médica Sur pharmacovigilance system and their impact on patients. METHOD: Prospective study carried out from 2012 to 2015, where medica- tion prescriptions given to patients were recorded. Owing to heterogeneity, data were described as absolute numbers in a logarithmic scale. RESULTS: 292 932 prescriptions of 56 368 patients were analyzed, and 8.9% of medication errors were identified. The treating physician was re- sponsible of83.32% of medication errors, residents of 6.71% and interns of 0.09%. No error caused permanent damage or death. CONCLUSION: This is the pharmacovigilance study with the largest sample size reported. CITA: Gac Med Mex. 2018; 154(2):172-179 DOI: 10.24875/GMM.18002549 285

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29735792 TÍTULO: A New Stage in Annals of Hepatology PMID: 29735798 AUTORES: Panduro A, Tiribelli C, Chávez-Tapia NC, Uribe M. SUMMARY: Editorial CITA: Ann Hepatol. 2018 May-June; 17(3):339-340 DOI: 10.5604/01.3001.0011.7377 TÍTULO: Thrombosis of the Portal Venous System in Cirrhotic vs. Non-Cir- rhotic Patients AUTORES: Cruz-Ramón V, Chinchilla-López P, Ramírez-Pérez O, Agui- lar-Olivos NE, Alva-López LF, Fajardo-Ordoñez E, Ponciano-Rodríguez G, Northup PG, Intagliata N, Caldwell SH, Qi X, Méndez-Sánchez N. INTRODUCTION AND AIM: Thrombosis is a vascular disorder of the liver often associated with significant morbidity and mortality. Cirrhosis is a pre- disposing factor for portal venous system thrombosis. The aim of this study is to determine differences between cirrhotics and non-cirrhotics that devel- op thrombosis in portal venous system and to evaluate if cirrhosis severity is related to the development of portal venous system thrombosis. MATERIAL AND METHODS: We studied patients diagnosed with portal ve- nous system thrombosis using contrast-enhanced computed tomography scan and doppler ultrasound at Medica Sur Hospital from 2012 to 2017. They were categorized into two groups; cirrhotics and non-cirrhotics. We assessed the hepatic function by Child-Pugh score and model for end-stage liver disease. RESULTS: 67 patients with portal venous system thrombosis (25 with non-cirrhotic liver and 42 with cirrhosis) were included. The mean age (± SD) was 65 ± 9.5years in cirrhotic group and 57 ± 13.2 years (p = 0.009) in non-cirrhotic group. Comparing non-cirrhotics and cirrhotics, 8 non-cirrhotic patients showed evidence of extra-hepatic inflammatory conditions, while in the cirrhotic group no inflammatory conditions were found (p &lt; 0.001). 27 (64.29%) cirrhotic patients had thrombosis in the portal vein, while only 9 cases (36%) were found in non-cirrhotics (p = 0.02). CONCLUSIONS: In cirrhotic patients, hepatocellular carcinoma and cirrho- sis were the strongest risk factors to develop portal venous system thrombo- sis. In contrast, extrahepatic inflammatory conditions were main risk factors associated in non-cirrhotics. Moreover, the portal vein was the most frequent site of thrombosis in both groups. CITA: Ann Hepatol. 2018 May-June; 17(3):476-481 DOI: 10.5604/01.3001.0011.7392 PMID: 29738105 TÍTULO: Chemotherapy-induced erythrodysesthesia of the breast AUTORES: Alcalde-Castro J, Soto-Perez-de-Celis E, Reyes-Gutiérrez E, Orozco-Topete R, León-Rodríguez E, Chávarri-Guerra Y. SUMMARY: Case report CITA: Breast J. 2018 Sep; 24(5):828-830 DOI: 10.1111/tbj.13048 286

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29744661 TÍTULO: Update on Omalizumab for Urticaria: What's New in the Literature from Mechanisms to Clinic AUTORES: Larenas-Linnemann DES, Parisi CAS, Ritchie C, Cardona-Vil- la R, Cherrez-Ojeda I, Cherrez A, Ensina LF, Garcia E, Medina IV, Rodrí- guez-González M, Caraballo JMS. PURPOSE OF REVIEW: Since omalizumab has been approved for urticaria, numerous randomized and real-life observational trials have been published. We reviewed the period January 2017-February 2018. RECENT FINDINGS: Omalizumab is effective for the control of urticaria re- calcitrant to antihistamines in different populations globally. The ratio of total serum IgE 4-week/baseline ≥2 can predict response with a high likelihood. In observational real-life trials, doses have been adjusted on an individual basis: in some populations, up to two-thirds of the patients can be controlled with 150 mg/month; however, others are still not controlled with 300 mg/ month. In these, 150 mg bimonthly could be tried, before up-dosing to 450 mg/month. On the long run (up to 3 years) omalizumab kept its efficacy. In many patients, dosing intervals could be augmented (6-8 weeks, some even more). After a 12-monthtreatment, about 20% showed long-term remission without relapse. Some biomarkers are being detected. Adjusting omalizum- ab doses in urticaria patients could enhance efficacy (shortening dosing in- terval and/or augmenting dose) and save costs (after 12 months: extending dosing interval and/or reducing dose). CITA: Curr Allergy Asthma Rep. 2018 May 9; 18(5):33 DOI: 10.1007/s11882-018-0787-5 PMID: 29752515 TÍTULO: Epidemiology and pathophysiology of neurogenic bladder after spi- nal cord injury AUTORES: Hamid R, Averbeck MA, Chiang H, Garcia A, Al Mousa RT, Oh SJ, Patel A, Plata M, Del Popolo G. SUMMARY: Spinal cord injury (SCI) usually affects younger age groups with male preponderance. The most common traumatic cause is road traffic acci- dent followed by sports accidents and gun-shot injuries. Infections and vas- cular events make up non-traumatic causes. There is regional variance in incidence and prevalence of SCI. Most systematic reviews have been under- taken from USA, Canada, and Australia with only few from Asia with resul- tant difficulty in estimation of worldwide figures. Overall, the incidence varies from 12 to more than 65 cases/million per year. The first peak is in young men between 15 and 29 years and second peak in older adults. The average age at injury is 40 years, with commonest injury being incomplete tetraplegia followed by complete paraplegia, complete tetraplegia, and incomplete para- plegia. The bladder function is reliant on both central and peripheral nervous systems for co-ordination of storage and voiding phases. The pathophysiol- ogy of bladder dysfunction can be described as an alteration in micturition reflex. It is postulated that a new spinal reflex circuit develops which is me- diated by C fibers as response to reorganization of synaptic connections in spinal cord. This is responsible for the development of neurogenic detrusor overactivity (NDO). Various neurotrophic hormones like nerve growth factor affect the morphological and physiological changes of the bladder afferent neurons leading to neuropathic bladder dysfunction. A supra sacral SCI usually results in a voiding pattern consistent with NDO and sphincter dys- 287

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29774774 synergia. Injury to either the sacral cord or cauda equina results in detrusor PMID: 29803325 hypoactivity/areflexia with sphincter weakness. CITA: World J Urol. 2018 Oct;36(10):1517-1527 DOI: 10.1007/s00345-018-2301-z TÍTULO: Undertreatment of pain and low use of opioids in Latin America AUTORES: García CA, Santos Garcia JB, Rosario Berenguel Cook MD, Colimon F, Flores Cantisani JA, Guerrero C, Rocío Guillén Núnez MD, Hernández Castro JJ, Kraychete DC, Lara-Solares A, Lech O, Rico Pazos MA, Gallegos MS, Marcondes LP. SUMMARY: Pain is highly prevalent among the adult Latin American pop- ulation. However, many patients with moderate to severe pain do not have access to effective pain management with opioids due to limited access to healthcare, overuse of nonopioid analgesics, regulatory barriers and lack of appropriate information about opioids. There is scarce training on use of opi- oids among physicians and other healthcare providers, which leads to mis- conceptions, mainly related to a fear of prescribing opioids. Although opioids are safe and effective drugs for the treatment of moderate to severe chronic pain, the use of opioids in Latin American nations is clearly below standards compared with developed countries. CITA: Pain Manag. 2018 May;8(3):181-196 DOI: 10.2217/pmt-2017-0043 TÍTULO: The Mexican consensus on the treatment of hepatitis C AUTORES: Aiza-Haddad I, Ballesteros-Amozurrutia A, Borjas-Almaguer OD, Castillo-Barradas M, Castro-Narro G, Chávez-Tapia N, Chirino-Sprung RA, Cisneros-Garza L, Dehesa-Violante M, Flores-Calderón J, Flores-Gaxiola A, García-Juárez I, González-Huezo MS, González-Moreno EI, Higuera-de la Tijera F, Kershenobich-Stalnikowitz D, López-Méndez E, Malé-Velázquez R, Marín-López E, Mata-Marín JA, Méndez-Sánchez N, Monreal-Robles R, Moreno-Alcántar R, Muñoz-Espinosa L, Navarro-Alvarez S, Pavia-Ruz N, Pérez-Ríos AM, Poo-Ramírez JL, Rizo-Robles MT, Sánchez-Ávila JF, San- doval-Salas R, Torre A, Torres-Ibarra R, Trejo-Estrada R, Velarde-Ruiz Vel- asco JA, Wolpert-Barraza E, Bosques-Padilla F. SUMMARY: The aim of the Mexican Consensus on the Treatment of Hepa- titis C was to develop clinical practice guidelines applicable to Mexico. The expert opinion of specialists in the following areas was taken into account: gastroenterology, infectious diseases, and hepatology. A search of the med- ical literature was carried out on the MEDLINE, EMBASE, and CENTRAL databases through keywords related to hepatitis C treatment. The quality of evidence was subsequently evaluated using the GRADE system and the consensus statements were formulated. The statements were then voted upon, using the modified Delphi system, and reviewed and corrected by a panel of 34 voting participants. Finally, the level of agreement was classi- fied for each statement. The present guidelines provide recommendations with an emphasis on the new direct-acting antivirals, to facilitate their use in clinical practice. Each case must be individualized according to the comor- bidities involved and patient management must always be multidisciplinary. CITA: Rev Gastroenterol Mex. 2018 Jul - Sep;83(3):275-324 DOI: 10.1016/j.rgmx.2017.11.001 288

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29809190 TÍTULO: [Implementation of intraoperative neurophysiologic monitoring PMID: 29813071 in children and adults in secondary and tertiary health care facilities] AUTORES: Maza-Krzeptowsky LC, Romero-Esquiliano G, Ramírez-Se- gura EH, Obieta-Cruz E, Vega-Sosa A, Cárdenas-Mejía A, Juan-Orta DS, Castillo-Herrera M, Aguilar-Castillo SJ, Ávila-Ordóñez MU, Corde- ro-Guzmán LM, Escobar-Cedillo RE, Fraire-Martínez MI, Franco-Lira MO, González-Jaime JJ, Paz-Navarro CE, Ramos-Peek JN, Shkurovich-Bialik P, Silva-Cerecedo P, Tello-Valdés CA, Zavala-Reina ÁA, López-Rodríguez J, Sosa-García O. INTRODUCTION: Intraoperative neurophysiological monitoring (IONM) is a procedure that uses neurophysiological techniques in order to evaluate the motor and sensitive systems during surgeries that endanger the nervous system. METHOD: The approach, scope, target population, and clinical questions to beans wered were defined. A systematic search of the evidence was con- ducted step by step; during the first stage, clinical practice guidelines were collected, during the second stage systematic reviews were obtained, and during the third stage, clinical trials and observational studies were procured. The MeSH nomenclature and free related terminology were used, with no language restrictions and a 5-10 years frame. The quality of the evidence was graded using the CEPD and SIGN scales. RESULTS: Obtained using the search algorrhythms of 892 documents. Fif- ty-eight were chosen to be included in the qualitative synthesis. A meta-anal- ysis was not possible due to the heterogeneity of the studies. CONCLUSIONS: Eighteen recommendations were issued and will support the adequate use of the IONM. CITA: Cir Cir. 2018;86(2):132-139 DOI: 10.24875/CIRU.M18000021 TÍTULO: Elevated oxytocin and noradrenaline indicate higher stress levels in allergic rhinitis patients: Implications for the skin prick diagnosis in a pilot study AUTORES: Gotovina J, Pranger CL, Jensen AN, Wagner S, Kothgassner OD, Mothes-Luksch N, Palme R, Larenas-Linnemann D, Singh J, Mösges R, Felnhofer A, Glenk LM, Jensen-Jarolim E. BACKGROUND & AIMS: The effects of acute stress on allergic symptoms are little understood. The intention of this clinical study was to study the ef- fects of acute stress and related mediators in allergic rhinitis (AR), taking the wheal and flare reaction in skin prick testing (SPT) as a readout. METHODS: 19 healthy and 21 AR patients were first subjected to SPTs with grass pollen-, birch pollen- and house dust mite allergen extracts, histamine and negative control. Subsequently, participants were exposed to a stan- dardized Trier Social Stress Test (TSST), followed by SPT on the contralater- al forearm. Stress responders were identified based on the salivary cortisol levels and State-subscale of State-Trait-Anxiety Inventory (STAI-S). Blood samples were collected before and after TSST and adrenaline, noradrena- line, serotonin, oxytocin, platelet activating factor and prostaglandin D2 were analyzed by enzyme immunoassay (EIA). 289

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR RESULTS: SPT results of 14/21 allergics and 11/19 healthy who responded with stress after TSST were evaluated. No significant differences regarding SPT to allergens or histamine before and after the stress test could be calcu- lated at the group level. But, the wheal and flare sizes after TSST increased or decreased substantially in several individuals, and unmasked sensitiza- tion in one \"healthy\" person, which could not be correlated with any mediator tested. The most significant finding, however, was that, independent of TSST, the baseline levels of oxytocin and noradrenaline were significantly higher in allergics. CONCLUSION: High baseline levels of noradrenaline points toward higher stress levels in allergic patients, which might be counter regulated by ele- vated oxytocin. Moreover, our data indicate that acute stress may have a significant influence on SPT fidelity in susceptible individuals. CITA: PLoS One. 2018 May 29;13(5):e0196879 DOI: 10.1371/journal.pone.0196879 PMID: 29862483 TÍTULO: Extensive Gastrointestinal Manifestations as the Main Relapsing Disease in Granulomatosis with Polyangiitis AUTORES: Vergara-Fernández O, Chablé-Montero F, Ruiz N, Mitre- -Reyes D, Cerda-Contreras E, Hernández A, Marroquín-Fabián E, Flores- -Suárez LF. SUMMARY: Case Report CITA: Dig Dis Sci. 2018 Oct;63(10):2810-2812 DOI: 10.1007/s10620-018-5147-8 PMID: 29871683 TÍTULO: Transient portal vein thrombosis in liver cirrhosis AUTORES: Qi X, Guo X, Yoshida EM, Méndez-Sánchez N, De Stefano V, Tacke F, Mancuso A, Sugawara Y, Yang SS, Teschke R, Arora A, Valla DC. SUMMARY: In real-world clinical practice, the acceptance of anticoagulation therapy in the management of portal vein thrombosis (PVT) in patients with cirrhosis is limited by the fear of an increased bleeding risk. Additionally, ac- cumulating evidence indicates that spontaneous recanalization of PVT may occur in the absence of antithrombotic treatment. Therefore, risk stratifica- tion based on outcomes in such patients is crucial for determining a thera- peutic strategy. In this paper, we draw attention to the distinct clinical entity, \"transient PVT\" by introducing two cases with PVT that spontaneously recan- alized in the absence of antithrombotic treatment. We reviewed the available data regarding the probability of and predictors for spontaneous recanaliza- tion of PVT. Available data suggest singling out transient thrombosis in the natural history of PVT inpatients with cirrhosis because of its prognostic and management implications. CITA: BMC Med. 2018 Jun 5; 16(1):83 DOI: 10.1186/s12916-018-1069-8 290

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29872290 TÍTULO: Prevalence of COPD and respiratory symptoms associated with biomass smoke exposure in a suburban area AUTORES: Ramírez-Venegas A, Velázquez-Uncal M, Pérez-Hernández R, Guzmán-Bouilloud NE, Falfán-Valencia R, Mayar-Maya ME, Aranda-Chávez A, Sansores RH. INTRODUCTION: Biomass smoke exposure (BSE) is a recognized cause of COPD particularly in rural areas. However, little research has been focused on BSE in suburban areas. OBJECTIVE: The aim of this study was to determine the prevalence of COPD, respiratory symptoms (RS) and BSE in women living in a suburban area of Mexico City exposed to BSE. METHODS: A cross-sectional epidemiological survey of a female population aged >35years was performed using a multistage cluster sampling strate- gy. The participants completed questionnaires on RS and COPD risk factors. The COPD prevalence was based on the postbronchodilator forced expirato- ry volume in the first second (FEV1)/forced vital capacity (FVC) ratio. Of the 1,333 women who completed the respiratory questionnaires, spirometry data were obtained from1,190, and 969 of these were scored as A-C. RESULTS: The prevalence of BSE was 47%, and the estimated prevalence of COPD was 2.5% for the total population (n=969) and 3.1% for those with BSE only. The spirometry and oximetry values were significantly lower in women with greater exposure levels. The prevalence of RS (cough, phlegm, wheezing and dyspnea) was significantly higher in the women with BSE compared to those without exposure. We concluded that the association of COPD with biomass exposure is not only a rural phenomenon but also may be observed in the suburban areas of the big cities. CITA: Int J Chron Obstruct Pulmon Dis. 2018 May 25;13:1727-1734 DOI: 10.2147/COPD.S156409 PMID: 29888440 TÍTULO: Kawasaki disease shock syndrome: Unique and severe subtype of Kawasaki disease AUTORES: Gamez-Gonzalez LB, Moribe-Quintero I, Cisneros-Castolo M, Varela-Ortiz J, Muñoz-Ramírez M, Garrido-García M, Yamazaki-Nakashi- mada M. BACKGROUND: Kawasaki disease shock syndrome (KDSS) is an uncom- mon presentation of Kawasaki disease (KD). KDSS has been associated with more severe markers of inflammation, coronary abnormalities and i.v. immunoglobulin (IVIG) resistance. METHODS: A retrospective, descriptive study of children with KDSS in two hospitals was performed. Relevant articles about KD and shock were col- lected, and demographic data, clinical presentation, laboratory variables, echocardiogram findings, treatment and special features were analyzed when available. Twelve patients diagnosed with KDSS were retrospectively reviewed from two centers in Mexico, along with 91 additional cases from the literature. RESULTS: Seventy-two patients presented with complete KD (69.9%), and 30.1%(31/103) had unusual KD manifestations. The most frequent diagnosis 291

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29893698 at the time of admission was toxic shock syndrome (TSS; n = 20). Sixteen PMID: 29894288 of the 20 had coronary artery abnormalities. Overall, abnormalities in the coronary arteries were documented in 65% of the patients. The mortality rate was 6.8%. CONCLUSION: The presence of coronary aneurysms was significantly and positively correlated with male gender, IVIG resistance, inotrope treatment, cardiac failure, abdominal pain and neurological symptoms. IVIG-resistant patients had higher neutrophil: lymphocyte ratio. Abdominal symptoms, hy- poalbuminemia and elevated C-reactive protein were present in almost all of the patients. Multisystem involvement with atypical presentation in KDSS is frequent. An important differential diagnosis is TSS. Mechanical ventilation, gastrointestinal and neurological symptoms were associated with IVIG resis- tance and the presence of coronary aneurysms. The first line of treatment in- cludes IVIG and pulse corticosteroids; in severe cases, infliximab, anakinra, cyclosporine or plasmapheresis are alternative treatment options. CITA: Pediatr Int. 2018 Sep;60(9):781-790 DOI: 10.1111/ped.13614 TÍTULO: Association Between Serum Hemoglobin Levels and Non Alcoholic Fatty Liver Disease in a Mexican Population AUTORES: Juárez-Hernández E, C Chávez-Tapia N, C Brizuela-Alcán- tara D, Uribe M, H Ramos-Ostos M, Nuño-Lámbarri N. INTRODUCTION AND AIM: Nonalcoholic fatty liver disease (NAFLD) is closely associated with overweight and obesity, becoming one of the most prevalent hepatic diseases nowadays. Circulating hemoglobin (Hb) concen- tration is significantly higher in people with NAFLD, compared to healthy pa- tients. While liver biopsy remains the gold standard for NAFLD diagnosis, it is not the best technique due to adverse events that may occur. Therefore it is important to find less invasive and more sensitive markers. This study aimed to determine the association of serum Hb levels in patients with ste- atosis and fibrosis as a noninvasive marker. MATERIAL AND METHODS: A 1,186 patient cross-sectional study nested in a randomized clinical trial (NCT01874249) was conducted. Patients were diagnosed by ultrasound for hepatic steatosis and fibroscan for fibrosis; blood test and anthropometric measurements were also assessed. RESULTS: Serum Hb increased proportionally related to the steatosis level, being significantly higher in patients with severe steatosis than in patients with moderate and mild steatosis. CONCLUSION: Patients with non-alcoholic fatty liver disease showed ele- vated levels of circulating Hb, evidence that suggests that Hb exerts a pro- tective role, as it may act as an antioxidant and may counteract the adverse effects of this disease. CITA: Ann Hepatol. 2018 July - August;17(4):577-584 DOI: 10.5604/01.3001.0012.0920 TÍTULO: Renovation of Annals of Hepatology's Scientific Scope: Towards Preventing Rather Than Treating End-Stage Liver Disease AUTORES: Panduro A, Tiribelli C, Chávez-Tapia NC, Arrese M, Uribe M. 292

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 29907965 SUMMARY: Editorial PMID: 29956689 CITA: Ann Hepatol. 2018 July - August;17(4):539-540 DOI: 10.5604/01.3001.0012.0913 TÍTULO: The Genetic Architecture of Diet-Induced Hepatic Fibrosis in Mice AUTORES: Hui ST, Kurt Z, Tuominen I, Norheim F, C Davis R, Pan C, Dirks DL, Magyar CE, French SW, Chella Krishnan K, Sabir S, Campos-Pérez F, Méndez-Sánchez N, Macías-Kauffer L, León-Mimila P, Canizales-Quinteros S, Yang X, Beaven SW, Huertas-Vazquez A, Lusis AJ. SUMMARY: We report the genetic analysis of a \"humanized\" hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibro- sis. Mice carrying transgenes for human apolipoprotein E*3-Leiden and cho- lesteryl ester transfer protein and fed a \"Western\" diet were studied on the genetic backgrounds of over 100 inbred mouse strains. The mice developed hepatic inflammation and fibrosis that was highly dependent on genetic back- ground, with vast differences in the degree of fibrosis. Histological analysis showed features characteristic of human NASH, including macrovesicular ste- atosis, hepatocellular ballooning, inflammatory foci, and pericellular collagen deposition. Time course experiments indicated that while hepatic triglyceride levels increased steadily on the diet, hepatic fibrosis occurred at about 12 weeks. We found that the genetic variation predisposing to NASH and fibrosis differs markedly from that predisposing to simple steatosis, consistent with a multistep model in which distinct genetic factors are involved. Moreover, ge- nome-wide association identified distinct genetic loci contributing to steatosis and NASH. Finally, we used hepatic expression data from the mouse panel and from 68 bariatric surgery patients with normal liver, steatosis, or NASH to identify enriched biological pathways. The pathways showed substantial overlap between our mouse model and the human disease. CITA: Hepatology. 2018 Dec;68(6):2182-2196 DOI: 10.1002/hep.30113 TÍTULO: Association of coagulopathy with the risk of bleeding after invasive procedures in liver cirrhosis AUTORES: Li J, Han B, Li H, Deng H, Méndez-Sánchez N, Guo X, Qi X. BACKGROUND/AIM: Bleeding risk among patients with acute or chronic liv- er disease after invasive procedures is a common concern in clinical practice. This retrospective study aimed to explore whether the presence of coagulopa- thy increased the risk of major bleeding after invasive procedures in cirrhosis. PATIENTS AND METHODS: A total of 874 cirrhotic patients underwent inva- sive procedures. Coagulopathy was defined as international normalized ratio (INR) ≥1.5and/or platelets (PLTs) ≤50 × 109/L. Severe thrombocytopenia was defined as PLTs ≤ 50 × 109/L. Invasive procedures, major bleeding after invasive procedures, and in-hospital deaths were recorded. RESULTS: In all, 296 patients (33.9%) had coagulopathy. Major bleeding after invasive procedures occurred in 21 patients (2.4%). Major bleeding after invasive procedures was more frequent in patients with coagulopathy than those without coagulopathy (4.1% vs 1.6%, P = 0.023). Major bleeding 293

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR after invasive procedures was more frequent in patients with severe throm- bocytopenia than those without severe thrombocytopenia (4.9% vs 1.6%, P = 0.008). Incidence of major bleeding after invasive procedures was not sig- nificantly different between patients with INR ≥ 1.5 and INR < 1.5 (4.5% vs 2.0%, P = 0.065). Patients with INR ≥1.5 had a significantly higher in-hospi- tal mortality than those with INR < 1.5 (6.4% vs1.3%, P < 0.001). CONCLUSION: Severe thrombocytopenia significantly increased the risk of major bleeding after invasive procedures in cirrhosis. INR ≥ 1.5 significantly increased in-hospital mortality. CITA: Saudi J Gastroenterol. 2018 Jul-Aug;24(4):220-227 DOI: 10.4103/sjg.SJG_486_17 PMID: 29999223 TÍTULO: Electronic Clinical Decision Support System for allergic rhinitis management: MASK e-CDSS AUTORES: Courbis AL, (…) Larenas Linnemann D, et al. BACKGROUND: Allergic rhinitis (AR) management has changed in recent years following the switch from the concept of disease severity to the con- cept of disease control, publication of the AR clinical decision support sys- tem (CDSS)and development of mobile health (m-health) tools for patients (eg Allergy Diary). The Allergy Diary Companion app for healthcare provid- ers is currently being developed and will be launched in 2018. It incorporates the AR CDSS to provide evidence-based treatment recommendations, link- ing all key stakeholders in AR management. OBJECTIVE: To produce an electronic version of the AR CDSS (e-CDSS) for incorporation into the Allergy Diary Companion, to describe the app in- terfaces used to collect information necessary to inform the e-CDSS and to summarize some key features of the Allergy Diary Companion. METHODS: The steps involved in producing the e-CDSS and incorporating it into the Allergy Diary Companion were (a) generation of treatment man- agement scenarios;(b) expert consensus on treatment recommendations; (c) generation of electronic decisional algorithms to describe all AR CDSS scenarios; (d) digitization of these algorithms to form the e-CDSS; and (e) embedding the e-CDSS into the app to permit easy user e-CDSS interfacing. RESULTS: Key experts in the AR field agreed on the AR CDSS approach to AR management and on specific treatment recommendations provided by Allergy Diary Companion. Based on this consensus, decision processes were developed and programmed into the Allergy Diary Companion using Titanium App celerator (JavaScript) for IOS tablets. To our knowledge, this is the first time the development of any m-health tool has been described in this transparent and detailed way, providing confidence, not only in the app, but also in the provided management recommendations. The Allergy Diary Companion for providers provides guideline and expert-en- dorsed AR management recommendations. [MASK paper No 32]. CITA: Clin Exp Allergy. 2018 Dec;48(12):1640-1653 DOI: 10.1111/cea.13230 294

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 30011790 TÍTULO: New Aspects of Lipotoxicity in Nonalcoholic Steatohepatitis AUTORES: Mendez-Sanchez N, Cruz-Ramon VC, Ramirez-Perez OL, Hwang JP, Barranco-Fragoso B, Cordova-Gallardo J. SUMMARY: NASH is becoming increasingly common worldwide because of the growing global prevalence of obesity and consequently NAFLD. Unfortu- nately, the mechanism of progression of NAFLD to NASH and then cirrhosis is not completely understood. Several factors, including insulin resistance, inflammation, oxidative stress, lipotoxicity, and bile acid (BA) toxicity, have been reported to be associated with NASH progression. The release of fatty acids from dysfunctional and insulin-resistant adipocytes results in lipotoxic- ity, which is caused by the ectopic accumulation of triglyceride-derived toxic metabolites and the subsequent activation of inflammatory pathways, cellu- lar dysfunction, and lipoapoptosis. Adipose tissue (AT), especially visceral AT, comprises multiple cell populations that produce adipokines and insulin-like growth factor, plus macrophages and other immune cells that stimulate the development of lipotoxic liver disease. These biomolecules have been re- cently linked with many digestive diseases and gastrointestinal malignancies such as hepatocellular carcinoma. This made us question what role lipotox- icity has in the natural history of liver fibrosis. Therefore, this review focuses on the close relationship between AT and NASH. A good comprehension of the pathways that are related to dysregulated AT, metabolic dysfunction, and hepatic lipotoxicity will result in the development of prevention strategies and promising therapeutics for patients with NASH. CITA: Int J Mol Sci. 2018 Jul 13;19(7) DOI: 10.3390/ijms19072034 PMID: 30061979 TÍTULO: Geolocation with respect to personal privacy for the Allergy Diary app - a MASK study AUTORES: Samreth D, (…) Larenas-Linnemann D, et al. BACKGROUND: Collecting data on the localization of users is a key issue for the MASK (Mobile Airways Sentinel networK: the Allergy Diary) App. Data anonymization is a method of sanitization for privacy. The European Commission's Article 29Working Party stated that geolocation information is personal data. To assess geolocation using the MASK method and to com- pare two anonymization methods in the MASK database to find an optimal privacy method. METHODS: Geolocation was studied for all people who used the Allergy Diary App from December 2015 to November 2017 and who reported med- ical outcomes. Two different anonymization methods have been evaluated: Noise addition(randomization) and k-anonymity (generalization). RESULTS: Ninety-three thousand one hundred and sixteen days of VAS were collected from 8535 users and 54,500 (58.5%) were geo localized, cor- responding to 5428users. Noise addition was found to be less accurate than k-anonymity using MASK data to protect the users' life privacy. DISCUSSION: k-anonymity is an acceptable method for the anonymization of MASK data and results can be used for other databases. CITA: World Allergy Organ J. 2018 Jul 16;11(1):15 DOI: 10.1186/s40413-018-0194-3 295

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 30073040 TÍTULO: Incidence of Delirium in Critically Ill Cancer Patients AUTORES: Sánchez-Hurtado LA, Hernández-Sánchez N, Del Mor- al-Armengol M, Guevara-García H, García-Guillén FJ, Herrera-Gómez Á, Ñamendys-Silva SA. OBJECTIVE: The aim of this study was to estimate the incidence of delirium and its risk factors among critically ill cancer patients in an intensive care unit (ICU). MATERIALS AND METHODS: This is a prospective cohort study. The Con- fusion Assessment Method for the Intensive Care Unit (CAM-ICU) was mea- sured daily at morning to diagnose delirium by a physician. Delirium was diagnosed when the daily was positive during a patient's ICU stay. All pa- tients were followed until they were discharged from the ICU. Using logistic regression, we estimated potential risk factors for developing delirium. The primary outcome was the development of ICU delirium. RESULTS: There were 109 patients included in the study. Patients had a mean age of 48.6 ± 18.07 years, and the main reason for admission to the ICU was septic shock (40.4%). The incidence of delirium was 22.9%. The mortality among all subjects was 15.6%; the mortality rate in patients who developed delirium was12%. The only variable that had an association with the development of delirium in the ICU was the days of use of mechanical ventilation (OR: 1.06; CI 95%:0.99-1.13;p=0.07). CONCLUSION: Delirium is a frequent condition in critically ill cancer pa- tients admitted to the ICU. The duration in days of mechanical ventilation is potential risk factors for developing delirium during an ICU stay. Delirium was not associated with a higher rate of mortality in this group of patients. CITA: Pain Res Manag. 2018 Jul 8;2018:4193275 DOI: 10.1155/2018/4193275 PMID: 30102202 TÍTULO: Radiation Oncology in Mexico: Toward a Unified Model PMID: 30122561 AUTORES: Gallegos D, Poitevin Chacón MA, Wright JL. PMID: 30134113 SUMMARY: Editorial CITA: Int J Radiat Oncol Biol Phys. 2018 Sep 1;102(1):5-10 DOI: 10.1016/j.ijrobp.2018.05.035 TÍTULO: HIV and Mexican drug law reform: good intentions wasted? AUTORES: Gonzalez-Pier E, Panopoulou G. SUMMARY: Comment CITA: Lancet Public Health. 2018 Sep;3(9):e410-e411 DOI: 10.1016/S2468-2667(18)30162-2 TÍTULO: Acute Respiratory Distress Syndrome Potentially Caused by Respi- ratory Syncytial Virus and a Diatom 296

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 30154051 AUTORES: Ñamendys-Silva SA, Sansores-Martínez R, García-García PMID: 30168185 AE, Castañeda-Méndez PF, Díaz-Flores O, Romero-González JP, González-Chon O. SUMMARY: Letter to the editor CITA: Am J Respir Crit Care Med. 2018 Dec 1;198(11):1447-1448 DOI: 10.1164/rccm.201802-0345IM TÍTULO: Distribution of Cervicocephalic Atherosclerotic Lesions and Their Correlation with Cardiovascular Risk Factors in a Population of Amerindians. The Atahualpa Project AUTORES: Del Brutto OH, Mera RM, Espinosa V, Nader JA, Zambrano M, Simon LV, Parikh PR, Castillo PR, Matcha G. BACKGROUND: No information is available on the distribution of cervicoce- phalic atherosclerosis in Amerindians. We aimed to assess the distribution of these lesions and their correlation with cardiovascular risk factors in Amerin- dians living in rural Ecuador. METHODS: Atahualpa residents aged ≥40years underwent head CT for assessment of carotid siphon calcifications (CSC) and sonographic exam- ination for measurement of the carotid intima media thickness (cIMT). CSC were used as a surrogate of intracranial atherosclerosis and the cIMT as a surrogate of extracranial atherosclerosis. Linear regression and multinomi- al logistic regression models were fitted to assess the association between cIMT and CSC, and to evaluate differences in risk factors across individuals with atherosclerosis involving both arterial beds when compared with those with extra- or intracranial atherosclerosis alone, or no atherosclerosis. RESULTS: Of 590 participants, 145 had high calcium content in the carotid siphon sand 87 had a cIMT >1mm (25% versus 15%, P < .001). Thirty-eight (7%) individuals had atherosclerosis at both vascular beds, 107 (18%) had intracranial atherosclerosis, and 49 (8%) had extracranial atherosclerosis alone. The cIMT and CSC were independently associated (P = .008). When compared with participants without atherosclerosis, those with atherosclero- sis at both vascular beds were older, more often male, hypertensive and dia- betic. Subjects with intracranial atherosclerosis alone were older, and those with extracranial atherosclerosis alone reported less physical activity than those without atherosclerosis. CONCLUSION: Intracranial atherosclerosis is more common than extracra- nial atherosclerosis in Amerindians. Traditional risk factors only explain a minority of cases of cervicocephalic atherosclerosis in this population. CITA: J Stroke Cerebrovasc Dis. 2018 Nov;27(11):3356-3364 DOI: 10.1016/j.jstrokecerebrovasdis.2018.07.043 TÍTULO: Very rarely chronic urticaria can be caused by cancer and if so, resolves with its cure AUTORES: Larenas-Linnemann D, Saini SS, Azamar-Jácome AA, Jensen- -Jarolim E, Maurer M. ABSTRACT: Letter to the editor 297

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR CITA: Allergy. 2018 Sep;73(9):1925-1926 DOI: 10.1111/all.13474 PMID: 30186137 TÍTULO: Searching for the Culprit: Metastases from a Cancer of Unknown Primary PMID: 30192644 AUTORES: Dorantes-Heredia R, Motola-Kuba D, Ruiz-Morales JM, PMID: 30193790 Muñoz-Castañeda WRA, Vega-Ochoa C, De la Peña R. SUMMARY: We report a case of metastases from a cancer of unknown primary whose primary site could not be identified during the appropriate pretreatment evaluation. The patient was a 58-year-old woman with a history of passive smoking and with no history of cancer in the family. Her current condition started with asthenia, adynamia, and pallor, followed by palpita- tions. An abdominopelvic computed tomography (CT) scan was performed, showing multiple osteolytic lesions distributed in all bone structures and ax- illary adenopathy on the left side. As part of the approach and given the high suspicion of multiple myeloma, tests were performed. The results were neg- ative for multiple myeloma. A PET-CT scan was performed and showed left axillary adenopathy. The breasts and other organs were not affected. Left axillary lymph node resection revealed breast primary metastatic pleomor- phic lobular carcinoma. Due to the metastatic disease (caused by the prima- ry breast cancer), it was decided to start chemotherapy. CITA: Case Rep Oncol. 2018 Aug 10;11(2):541-548 DOI: 10.1159/000491600 TÍTULO: Organ Function Assessment, Prevention, and Outcomes in Critical- ly Ill Patients with Sepsis AUTORES: Rojo Del Moral O, Mena-Arceo RG, García-García AE, Ñamendys-Silva SA. SUMMARY: Letter to the editor CITA: Am J Respir Crit Care Med. 2018 Dec 1;198(11):1444-1446 DOI: 10.1164/rccm.201705-0982RR TÍTULO: The relationship between the neck circumference and the carotid intima-media thickness in Amerindians. Potential links to health risks? AUTORES: Del Brutto OH, Mera RM, Nader JA, Zambrano M, Castillo PR, Matcha G, Simon LV. SUMMARY: The carotid intima media thickness (cIMT) is a predictor of car- diovascular events. The neck circumference (NC) has been investigated as a risk factor for increased cIMT with contradictory results. This study assessed the relationship between NC and cIMT in Atahualpa residents aged ≥40 years who had sonographic examination of carotid arteries (n = 590). We also discussed on potential pathogenetic mechanisms underlying this association. Participants belonged to the Native Ecuadorian (Amerindians) ethnic group. Non-parametric regression models were used to assess the aforementioned relationship, after adjusting for relevant confounders. The mean age of partic- ipants was 60.9 ± 12.7 years (58% women). The mean value of the cIMT was 298

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 30197183 0.85 ± 0.19 mm. The mean NC was 35.8 ± 34 cm. The NCwas normally dis- PMID: 30211197 tributed, but the cIMT was not. Mean values of NC and cIMT were significant- ly greater in men than in women. Non-parametric models showed significant differences in median cIMT values according to quartiles of NC. Predictive cIMT margins increased by quartiles of NC, significantly among individuals in the 1st quartile as compared to the 3rd quartile. In this population of Amerindi- ans, smaller NC is associated with lower values of cIMT. The pattern of this association is different in men than in women. Sex-related differences in cervical fat tissue distribution probably accounted for such dif- ferences. CITA: Pathophysiology. 2018 Dec;25(4):427-431 DOI: 10.1016/j.pathophys.2018.08.007 TÍTULO: Clinical guidelines on the diagnosis and treatment of celiac disease in Mexico AUTORES: Remes-Troche JM, Uscanga-Domínguez LF, Aceves-Tavares RG, Calderón de la Barca AM, Carmona-Sánchez RI, Cerda-Contreras E, Coss-Adame E, Icaza-Chávez ME, Lopéz-Colombo A, Milke-García MP, Morales-Arámbula M, Peláez-Luna M, Ramos Martínez P, Sánchez-Sosa S, Treviño-Mejía MC, Vázquez-Frías R, Worona-Dibner LB, Zamora-Nava LE, Rubio-Tapia A. SUMMARY: Celiac disease, celiac sprue, or gluten-sensitive enteropathy, is a generalized autoimmune disease characterized by chronic inflammation and atrophy of the small bowel mucosa. It is caused by dietary exposure to gluten and affects genetically predisposed individuals. In Mexico, at least 800,000 are estimated to possibly have the disease, prompting the Asociación Mexi- cana de Gastroenterología to summon a multidisciplinary group of experts to develop the \"Clinical guidelines on the diagnosis and treatment of celiac dis- ease in Mexico\" and establish recommendations for the medical community, its patients, and the general population. The participating medical profession- als were divided into three working groups and were given the selected bib- liographic material by the coordinators (ART, LUD, JMRT), who proposed the statements that were discussed and voted upon in three sessions: two voting rounds were carried out electronically and one at a face-to-face meeting. Thir- ty-nine statements were accepted, and once approved, were developed and revised by the coordinators, and their final version was approved by all the participants. It was emphasized in the document that epidemiology and risk factors associated with celiac disease (first-degree relatives, autoimmune dis- eases, high-risk populations) in Mexico are similar to those described in other parts of the world. Standards for diagnosing the disease and its appropriate treatment in the Mexican patient were established. The guidelines also high- lighted the fact that a strict gluten-free diet is essential only in persons with confirmed celiac disease, and that the role of gluten is still a subject of debate in relation to nonceliac, gluten-sensitive patients. CITA: Rev Gastroenterol Mex. 2018 Oct - Dec;83(4):434-450 DOI: 10.1016/j.rgmx.2018.05.005 TÍTULO: The usefulness of transient elastography in patients with atoim- mune hepatitis-when can we use it? AUTORES: Méndez-Sánchez N, Qi X. 299

RESÚMENES DE ARTÍCULOS PUBLICADOS POR MÉDICOS E INVESTIGADORES DE MÉDICA SUR PMID: 30231359 SUMMARY: Editorial PMID: 30278478 CITA: Ann Transl Med. 2018 Aug;6(15):309 DOI: 10.21037/atm.2018.06.38 TÍTULO: Global Epidemiology, Prevention, and Management of Hepatocellu- lar Carcinoma AUTORES: Mak LY, Cruz-Ramón V, Chinchilla-López P, Torres HA, LoCon- te NK, Rice JP, Foxhall LE, Sturgis EM, Merrill JK, Bailey HH, Méndez-Sán- chez N, Yuen MF, Hwang JP. SUMMARY: The incidence rate of hepatocellular carcinoma (HCC) is rising. It is one of the most common cancers worldwide and accounts for substan- tial morbidity and mortality. Chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus(HCV) infection, and nonalcoholic fatty liver disease (NA- FLD) are the most important etiologies of HCC, and effective screening and management strategies are crucial to reduce the HCC risk. For HBV, which accounts for the majority of HCC cases, most infections were acquired via perinatal and early horizontal transmission. Universal vaccination of new- borns has led to a decline in HCC incidence compared with the pre-vacci- nation era. Effective antiviral therapies with nucleos(t)ide analogues or pe- gylated interferon reduced the incidence of HCC. For HCV, the emergence of effective direct-acting antiviral (DAA) agents has substantially improved cure rates; therefore all patients with HCV should be considered for DAA treatment. The most important obstacle in eliminating HCV is access to ther- apy. For NAFLD, the global incidence is increasing rapidly, thus its impact on HCC incidence may be explosive. Progression to HCC in NAFLD hap- pens particularly in those with nonalcoholic steatohepatitis (NASH) and ex- acerbated by metabolic syndrome, or PNPLA3 gene polymorphism. Lifestyle changes are imperative while drug therapy has yet to demonstrate substan- tive protective effects on HCC prevention. For management of HCC, early diagnosis via imaging surveillance among persons with HCC risk factors re- mains the most important strategy to identify early-stage disease appropriate for resection or transplantation. CITA: Am Soc Clin Oncol Educ Book. 2018 May 23;38:262-279 DOI: 10.1200/EDBK_200939 TÍTULO: [Mexican consensus on the diagnosis and treatment of atopic der- matitis in adolescents and adults] AUTORES: Rincón-Pérez C, Larenas-Linnemann D, Figueroa-Morales MA, Luna-Pech J, García-Hidalgo L, Macías-Weinmann A, Gómez-Vera J, Bar- ba-Gómez JF, Matta-Campos JJ, Guevara-Sangines E, Jurado-Santacruz F, López Tello-Santillán A, Ortega-Martell JA, Pulido-Díaz N, Serrano-Jaén LG, Toledo-Bahena M, Villanueva-Quintero G, Mayorga-Butrón JL. BACKGROUND: The diagnostic approaches and therapeutic strategies of atopic dermatitis (AD) are generally inconsistent among physicians and health institutions. OBJECTIVE: To develop a consensus statement among experts to reduce the variations in practice regarding the diagnosis and treatment of patients ≥ 12years with AD to improve their care. 300