Brigham and Women's Hospital Department of Surgery Harvard Medical School External Review 2017-2021

Endovascular Cardiac 2019 GRADUATES Winta Mehtsun, MD Surgery Fellowship University of Virginia School of Medicine Zeynep Bilgi, MD Program Director: Tsuyoshi Kaneko, Assistant Professor, Thoracic Surgery, George Molina, MD MD Medeniyet University Medical School, Turkey Harvard Medical School Humbo Shim, MD Apostolos Kandalis, MD 2019 GRADUATE Hanyang University College of Medicine, Private General Surgery Practice, Athens Korea Euroclinic, Greece Akhil Chawla, MD Surgical Oncology Faculty, Northwestern University Feinberg School of Medicine General Thoracic Oral Oncology and Oral Urological Oncology Surgery Fellowship Medicine Fellowship Fellowship Program Director: Program Director: Alessandro Villa, Program Director: Michael T. Jaklitsch, MD DDS, PhD, MPH Steven L. Chang, MD, MS Moaiad Salous, DMD Jessica Della Valle Howard University College of Medicine Eugene Cone, MD University of Florida College of Medicine Warren Alpert Medical School of Brown 2019 GRADUATE University Rory Beattie King’s College London GKT School of Medical Paolo Fantozzi, DDS Melissa Huynh, MD Education Schulich School of Medicine & Dentistry at Surgical Critical Western University, Ontario, Canada Mayrim Rios Perez Care Fellowship University of Puerto Rico School of Medicine Alice Yu, MD Program Director: McGill University Medical School, Montreal, Matthew Pommerening Reza Askari, MD Canada McGovern Medical School at University of Allison Brown, MD Texas Health Science Center-Houston University of Wisconsin School of Medicine 2019 GRADUATES and Public Health 2019 GRADUATES Choyin Chung, MD Daniel Pucheril, MD University of Texas Medical Branch Attending Surgeon, Kettering Health Network, Rafael Castillion, MD Alfredo Cordova, MD Dayton, OH Staff, Hospital Angeles Chihuahua, Mexico Universidad de San Martin de Porres, Peru Laura Hansen, MD Dimitar Zlatev, MD Carolyn Moore, MD University of Connecticut School of Medicine Urology Faculty, Massachusetts General Cardiothoracic Surgery Fellowship, University Hospital of Kansas School of Medicine 2019 GRADUATES Vascular Surgery Fellowship Desiree Steimer, MD Ashley Aaron, MD Cardiothoracic Surgery Fellowship, Brigham Abdominal Transplant Fellow, Massachusetts Program Director: and Women’s Hospital General Hospital Matthew Menard, MD Mehreen Kisat, MD Danielle Thesier, MD Acute Care Surgery Fellow, Brigham and Andrew Soo Hoo, MD Vascular Surgery Fellowship, University Women’s Hospital Wayne State University School of Medicine of Buffalo Jacobs School of Medicine and Kathryn Van Orden, MD Biomedical Sciences Assistant Professor, Trauma and Acute Care Gaurav Sharma, MD Surgery, Boston Medical Center Keck School of Medicine of USC Minimally Invasive Thoracic Surgery Fellowship Surgical Oncology Fellowship Jillian Walsh, MD Schulich School of Medicine & Dentistry at Program Director: Program Director: Western University, Ontario, Canada Jon O. Wee, MD Chandrajit P. Raut, MD, MSc 2019 GRADUATE John S. Young, MD Rutgers Robert Wood Johnson Medical Christine Lotto, MD School Attending Surgeon, Capital Health, associated with the University of Medicine Ealaf Shemmeri, MD and Dentistry of New Jersey Ross University School of Medicine BWH DOS 23

ANNOUNCEMENTS Douglas S. Smink, MD, MPH, Receives Parker J. Palmer Courage to Teach Award from the Accreditation Council for Graduate Medical Education Dr. Smink was awarded a 2019 Parker J. Palmer Courage to Teach Award from the Accreditation Council for Graduate Medical Education (ACGME). The Parker J. Palmer Courage to Teach Award honors program directors who find innovative ways to teach residents and who provide quality health care while remaining connected to the initial impulse to care for others in this environment. Parker J. Palmer’s book The Courage to Teach promotes the concept of “living divided no more,” which has proven relevant to teaching in academic health centers. Dr. Smink is a minimally invasive general surgeon at Brigham and Women’s Hospital and associate professor of surgery at Harvard Medical School. His clinical interests include foregut surgery, biliary tract disease and abdominal wall hernias. He received his medical degree from the Perelman School of Medicine at the University of Pennsylvania. He completed a general surgery residency at the Brigham and a minimally invasive surgery fellowship at Dartmouth-Hitchcock Medical Center. He is the associate chair of education in the Department of Surgery and program director of the general surgery residency. Dr. Smink is the editor-in-chief of the Journal of Surgical Education and serves as a member of the editorial board of the Surgical Council on Resident Education (SCORE). His research focuses on resident and faculty education through simulation. He is co- leader of the Surgical Culture program at the Brigham Center for Surgery and Public Health (CSPH), where he studies how to teach communication, leadership and decision- making to surgeons and surgical teams. ª Douglas Smink and Danny Mou discussing a case in the operating room. 24 BWH DOS

NELYA MELNITCHOUK, MD, MSc, VISITING PROFESSORS Appointed Colorectal Surgery Fellowship Program Director David J. Sugarbaker Lectureship in Dr. Melnitchouk is an associate surgeon in the Division of General Thoracic Surgery and Gastrointestinal Surgery at Brigham and Women’s Hospital and Walter Klepetko, MD an assistant professor of surgery at Harvard Medical School. Medical University of Vienna, Austria She received her medical degree from Albert Einstein College of Gerald and Elaine Schuster Medicine and completed her general surgery residency at Brigham Distinguished Lecturer in Thoracic and Women’s Hospital followed by a colorectal surgery fellowship at Surgery the Memorial Sloan Kettering Cancer Center and NewYork-Presbyterian/Weill Cornell Ara Vaporciyan, MD, FACS, MHPE Medical Center. She is board certified in general surgery and colon and rectal surgery. MD Anderson Cancer Center Dr. Melnitchouk is active in health services research with a focus on appendiceal and colorectal cancers and access to care and disparities. She co-leads the cancer Joseph E. Murray Visiting Professor in and comparative effectiveness research core at the Brigham Center for Surgery and Transplant Surgery Public Health (CSPH). Dr. Melnitchouk is an active member of the American Society of Nancy L. Ascher, MD, PhD Colon and Rectal Surgeons (ASCRS) and the Society of Surgical Oncology (SSO). She UCSF School of Medicine also has multiple published manuscripts and book chapters. ª Gordon C. Vineyard Lecturer in STEPHANIE L. NITZSCHKE, MD, MS, AND NAOMI SHIMIZU, MD, Surgery Appointed Associate Directors of the General Surgery Residency Program Sandra L. Wong, MD, MS Geisel School of Medicine at Dartmouth Dr. Nitzschke is an acute care surgeon, trauma surgeon and surgical intensivist at Brigham and Women’s Hospital, where she Hechtman Trauma Lecturer in serves as medical director of the Burn Center and is an instructor Surgery in surgery at Harvard Medical School. Hasan B. Alam, MD She is a graduate of Loyola University Stritch School of Medicine University of Michigan Medical School and completed a general surgery residency at Inova Fairfax Hospital. Dr. Nitzschke completed a burn surgery fellowship at the U.S. Army Institute John A. Mannick Visiting Professor in of Surgical Research (USAISR) and a trauma and critical care fellowship at the Vascular Surgery University of Pennsylvania. ª Ronald M. Fairman, MD Perelman School of Medicine at the Dr. Shimizu is an acute care surgeon, trauma surgeon and surgical University of Pennsylvania intensivist at Brigham and Women’s Hospital and is an instructor in surgery at Harvard Medical School. Lawrence and Judith Schlager Family Lecturer in Surgical Oncology She is a graduate of the John A. Burns School of Medicine and Jeffrey A. Drebin, MD, PhD completed her general surgery residency at the University of Memorial Sloan Kettering Cancer Center California, San Francisco (East Bay); a research fellowship at University of California, San Francisco; and an acute care and surgical critical care fellowship at Lawrence H. Cohn Visiting Professor Brigham and Women’s Hospital. ª in Cardiac Surgery A. Marc Gillinov, MD Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Nina S. Braunwald Visiting Lecturer in Surgery Caprice C. Greenberg, MD, MPH University of Wisconsin School of Medicine and Public Health Zinner-Gelman Visiting Professor in Surgery, Anesthesiology, Perioperative and Pain Medicine Tomislav Mihaljevic, MD Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Pro Tempore Visiting Professor Francis D. Moore Lecturer in Surgery Timothy M. Pawlik, MD, MPH, MTS, PhD, FACS Ohio State University College of Medicine BWH DOS 25

jamie robertson Director of Innovation in Surgical Education Jamie Robertson, PhD, MPH, has Robertson plainly states. And yet, she health at the Western Pennsylvania taken on the newly created role of couldn’t seem to stay away from the School for Blind Children, and she director of Innovation in Surgical classroom. While studying creative was a member of a Fogarty training Education in the Department of writing and political science as an grant that provided basic clinical Surgery at Brigham and Women’s undergraduate at Seattle University, research training for physicians in Hospital. Dr. Robertson has long been she taught reading to students in India. involved in undergraduate, graduate kindergarten through third grade at a and continuing medical education, local elementary school. In fact, it was “This is an exciting opportunity to where she has amassed extensive a semester abroad teaching English expand beyond simulation and take experience creating curricula and in South Africa that would set her on advantage of innovative teaching assessments for learners in a variety the path to the intersection of public methods and new educational of medical and surgical specialties. health, health care and education. She technologies,” Dr. Robertson says Most recently, she served as director attributes a 50% HIV rate in a South of her new role. “The Department of Education at Brigham’s STRATUS African township to her volunteering of Surgery is a particularly good Center for Medical Simulation, where at an HIV peer education program place for these types of innovations, she oversaw the development and upon her return to Seattle and because it has long focused on implementation of simulation-based beginning work toward her MPH education and already has a great education and assessment programs and eventual PhD at the University of community of surgical educators.” for 14 of Brigham’s 16 departments. Pittsburgh. Dr. Robertson’s focus is on creating Focusing on Innovative faculty development programs Prior to coming to the Brigham, that promote the use of innovative Dr. Robertson served as the clinical Education teaching methodologies to improve outcomes and quality improvement both learning and feedback for director in the Department of “Surgery delivery is evolving, students and residents. Anesthesiology and Perioperative and surgical training is evolving,” Medicine at Oregon Health Douglas Smink, MD, MPH, associate Becoming an Educator Sciences University, where she chair of Education in the Department led the development of a quality of Surgery, explains. “We needed Long before Dr. Robertson improvement and clinical outcomes a faculty member who could work earned an MPH in behavioral and database and taught epidemiology one-on-one with program directors, community health sciences and a PhD and essentials of clinical practice to fellowship directors, clerkship in epidemiology, she was destined medical students. It was there that she directors and learners to take our for a career in education—even if became involved in simulation as a surgery education group to the next she didn’t know it. Growing up in member of an interdisciplinary mock level.” Cheyenne, Wyoming, her mother code team, bringing together the was a special education teacher and metrics used in mock codes with the Each year, the department educates her grandmother taught typing and metrics in real codes. approximately 400 learners, including shorthand. “I had absolutely no students, residents and fellows. interest in becoming a teacher,” Dr. Dr. Robertson was also the recipient “Our clerkship directors, residency of an Albert Schweitzer Fellowship directors and fellowship directors 26 BWH DOS (ASF) to teach human sexuality and can devote only a portion of their days to education work,” Dr. Smink

says. “Dr. Robertson will partner technology to mannequins and live- with these directors to help identify areas for innovation and enact those actor patients. improvements.” She will also focus on helping trainees enhance the way “The focus may be on improving that they learn and make the learning process more personalized. surgical technique, teamwork, “Dr. Robertson brings great communication skills, empathy expertise in simulation. In her time at STRATUS, she showed that she is or techniques such as history and someone who brings people together to get things done,” Dr. Smink says. physical exam,” Dr. Robertson Perhaps her best-known project there is the NASA simulation, where explains. “These are very important she oversaw the development of clinical scenarios and training on in many aspects of surgical training,” nontechnical skills, teamwork and decision-making during medical Dr. Smink adds. For example, one events in the limited-resource setting of space travel. These simulations current OR team training simulation focused on leadership roles and prioritizing medical events within the focused on the communication context of mission-critical operations. and teamwork skills essential for Enhancing the Surgical functionality and ensuring patient Education Experience safety in the OR setting involves a “Dr. Robertson will help us think “Dr. Robertsonteam of surgeons, anesthesiologists, a of new ways to deliver surgical education more efficiently and in nurse and a scrub tech during a five- a positive environment that helps residents, students and fellows retain will help us thinkhour training session. more knowledge,” Dr. Smink says. Gamification is another educational One opportunity for faculty of new ways totechnique that Dr. Robertson intends development is simulation. While to explore. Think of the popular simulation has been widely adopted fitness apps and self-development deliver surgical as a method of medical education, Dr. Robertson explains that few faculty challenges that many people use and development programs have courses designed to develop simulation education moreparticipate in on their smartphones educators. and tablets. “I’d like to explore how this model might work in surgical efficiently...” “At STRATUS, we created a education and find opportunities to workshop to train faculty on the knowledge and skills required utilize it,” she explains. “We need to DOUGLAS S. SMINK, MD, MPH to design clinical scenarios,” Dr. look at how we engage with learners Robertson says. The live, in-person workshop provides learners with the using the technology that they are assessments, as well as feedback, tools, skills and hands-on practice necessary to create a complete clinical already carrying around.” The goal are administered and tracked. scenario for use in any simulation center. It will be important to train here is short and engaging modules. For example, a new app allows more faculty in developing scenario- based simulations to meet the needs As part of an increased focus on trainees to have all their feedback of learners by utilizing everything from computers and virtual reality competency-based assessments in and assessments ready to view and medical education, the department complete in one place and provides a is currently involved in a pilot study complete view of their performance led by the American Board of Surgery against core EPAs. to define and validate entrustable “We’ll also be looking at enhancing professional activities (EPAs) for the way that faculty and residents surgical residents. “EPAs are defined engage in feedback,” Dr. Robertson tasks or responsibilities that we, as says. “Feedback is a two-way street,” educators, ask trainees to do and Dr. Smink adds. “Faculty need show that they can do these on a guidance on how to give impactful regular basis, before we trust them feedback in an honest, positive way to do it independently,” Dr. Smink that will truly help residents improve, explains. “For example, taking a and residents need guidance on how patient’s history or performing part to receive and process that feedback of a surgical procedure.” The pilot most effectively.” study aims to define EPAs for general “Having someone who can spend surgery and determine when a 100% of their time thinking about trainee has attained sufficient specific how we educate trainees and how we competence to be entrusted with a can do it better is really exciting,” Dr. given task. Smink says. “We’re looking forward Emerging digital assessment ttohiDs rp.rRoocebsesr.t”soªn leading and guiding technologies can enhance how such BWH DOS 27

Research Brigham Health is an international powerhouse in biomedical research dedicated to pioneering discoveries that will translate into new prediction methods, treatments, and cures for the world’s most devastating and complex diseases. 395 214 389 Total Research Funds Active Protocols Active Grants & Contracts 54 40 Research Fellows Active Clinical Trials $39,447,056 Total Research Spending

SELECTED GRANTS SELECTED CLINICAL TRIALS Long-term Oral Health Outcomes in CTA: The Use of Coronal Views in CTA: Transcatheter Replacement the Chronic GVHD Consortium (MPI) Breast Cancer Screening With ABUS of Stenotic Aortic Valve Through PIs • Herve Y. Sroussi, DMD, PhD and PI • Jeremy M. Wolfe, PhD Implantation of ACURATE in Subjects Nathaniel S. Treister, DMD, DMSc Sponsor • GE Precision Healthcare LLC InDicatEd for TAVR Sponsor • National Institutes of Health (NIH) PI • Tsuyoshi Kaneko, MD Grant Amount • $3,703,276 CTA: A Phase 2 Study for the Sponsor • Boston Scientific Corporation Evaluation of Safety and Efficacy of Combination Ipatasertib and Humacyte’s Human Acellular Vessel DFPCC: BWH Fund A Phase 3, Multi- Atezolizumab to Prevent Recurrence for Use as a Vascular Prosthesis for Center, Open-Label Study to Assess in TNBC Femoro-Popliteal Bypass in Patients the Diagnostic Performance and PI • Elizabeth Mittendorf, MD, PhD With Peripheral Arterial Disease Clinical Impact of 18F-DCFPyL PET/ Sponsor • Stand Up To Cancer (SU2C) PI • Michael Belkin, MD CT Imaging Results in Men With Grant Amount • $2,999,925 Sponsor • Atlantic Research Group, Inc. Suspected Recurrence of Prostate Cancer (CONDOR) Cancer Immunotherapy Research CRSA: Steering Committee and PI • Mark A. Preston, MD, MPH With imCORE Program Consulting - Phase 3 A Randomized, Sponsor • Progenics Pharmaceuticals, Inc. PI • Raphael Bueno, MD Double-Blind, Placebo-Controlled, Sponsor • Genentech, Inc. through Phase 3, Study of Apalutamide in Dana-Farber Cancer Institute Subjects with High-Risk, Localized or Grant Amount • $2,207,441 Locally Advanced Prostate Cancer Who are Candidates for Radical Multiple Object Awareness Prostatectomy PI • Jeremy M. Wolfe, PhD PI • Adam S. Kibel, MD Sponsor • National Science Foundation Sponsor • Janssen Research & (NSF) Development, LLC Grant Amount • $450,000 BWH DOS 29

FACULT Y SPOTLIGHT zara cooper Kessler Director, Center for Surgery and Public Health In March, Zara Cooper, MD, MSc, in communications. After a short intention of going into surgery; it took over as the new Kessler Director career in advertising, she returned wasn’t until my third year, when I of the Center for Surgery and Public to her native city to attend the loved the OR experience and realized Health (CSPH), a joint initiative Icahn School of Medicine at Mount that there was plenty of public health founded in 2005 by Brigham and Sinai, where she earned an MD and work to be done in surgery.” Women’s Hospital, Harvard Medical MSc in community medicine. The School and the T.H. Chan School of combination of training in surgery “After completing surgical training, Public Health. The center is dedicated and communications enables her I became committed to developing to advancing the science of surgical to pursue her passion—helping a research program in palliative care delivery with the goal of surgeons improve the difficult care and geriatrics,” Dr. Cooper, increasing access to safe, high-quality conversations they have with who is also certified in hospice and and equitable patient-centered care. their patients. Along with Atul palliative medicine, says. A trauma surgeon and surgical Gawande and other internationally intensivist, Dr. Cooper is no stranger recognized experts, she co-authored “The Center for Surgery and to the Department of Surgery, where recommendations for how surgeons Public Health has been my research she has established herself as a should communicate with seriously home for 12 years now,” Dr. Cooper national leader in surgical palliative ill, older patients and their families says. “It is incredibly humbling and and geriatric trauma care. when faced with acute surgical personally meaningful for me to be emergencies. sitting in this role in this place where After growing up in New York City, I have benefited so much,” she adds. Dr. Cooper headed west to attend “I have always been committed to Northwestern University, where a public health focus in my work,” Advancing Palliative she received a bachelor’s degree Dr. Cooper says. “Initially, I had no and Geriatric Care for Surgical Patients Frailty is a well-established marker of poor outcomes in geriatric trauma patients. “We developed a frailty care pathway that utilizes all the resourc- es of the trauma center, including geriatrics, nutrition, physical therapy, occupational therapy, nursing and house staff,” Dr. Cooper explains. The interdisciplinary protocol included early ambulation, bowel/ pain regimens, nonpharmacologic delirium prevention, nutrition/ physical therapy consults, geriatrics assessments and a family meeting for patients hospitalized longer than five days. The study, published in June 2019 in the Journal of the American College of Surgeons, showed that patients on the pathway had a 56% lower rate of delirium and a 75% lower rate of readmission 30 days after surgery, compared with patients 30 BWH DOS

treated the year before the pathway you get older, your goals change,” be used to develop targeted was implemented. “The nursing staff and house staff have taken she explains. “Surgeons should be interventions aimed at eradicating this initiative on as their own,” Dr. Cooper says. “Our goal is to expand asking patients about their goals disparities and improving outcomes. this initiative beyond trauma services to all surgical services.” of care.” She is collaborating with Frail, older patients also tend investigators at Dana-Farber Cancer Cultivating Cultural to suffer greater morbidity after Institute on using natural language Dexterity surgery, compared with their processing to assess end-of-life younger counterparts, as well as quality indicators in cancer patients The Provider Awareness and distressing physical, psychosocial receiving palliative surgery. “Natural Cultural Dexterity Toolkit for and functional impairments language processing uses the Surgeons (PACTS) trial at eight that reduce their quality of life. electronic health record to abstract academic medical centers is Importantly, their overall health information on whether or not evaluating a cultural dexterity goals often differ from younger patient goals are being assessed,” Dr. curriculum, which was developed by surgical patients. Palliative care, Cooper explains. former CSPH director Adil Haider, an interdisciplinary care approach MD, MPH, and is now led by Douglas focused on improving quality of life for patients and families, is integral Taking the Helm at CSPH Smink, MD, MPH, associate chair to providing quality care for these of Education in the Department patients. of Surgery. The cultural dexterity “Palliative care is a very important part of surgical care, but quality “I’m taking over the center during approach aims to give providers indicators for palliative care a good, stable growth phase, and the skills to adequately respond to traditionally are not included in I’m not keen to change too many cross-cultural differences without quality assessments of surgical care,” Dr. Cooper explains. In an April 2019 things,” Dr. Cooper explains. “My paper in Annals of Surgery, Dr. Cooper predecessor set up a great platform and colleagues identified palliative care quality measures from other “… there wasfor success and for our impact to specialties that could be adapted continue to grow. My goal is for the and employed to measure palliative care delivery within the American plenty of publicCSPH to be the very best place to do College of Surgeons’ (ACS) five surgical health services research.” phases of surgical care. health work Increasing Access to to be done in “We are obligated to understand Surgical Care the impact of what we do on end-of- life care,” Dr. Cooper says. “What surgery.”The CSPH has long been at the we do should improve quality of life for patients, not just increase forefront of research on disparities in survival and longevity. We don’t surgical and trauma care, uncovering want to provide nonbeneficial care that is not aligned with our patients’ and mitigating unequal surgical ZARA COOPER, MD, MSc preferences and their overall health health outcomes based on race, sex, goals.” sexual orientation, ethnicity, age and unintentionally enforcing existing Dr. Cooper and colleagues socioeconomic status. The current cultural stereotypes. Training of recently explored how clinical partnership with the ACS on an RO1 residents in the PACT trial is now teams communicate goals of care for grant from the National Institutes of underway, and residents will be their critically ill surgical patients, Health (NIH) aims to develop quality assessed not just on their knowledge including barriers and factors that metrics around access to surgical and and attitudes pre versus post training facilitate clinician-to-clinician trauma care. but also on patient satisfaction scores communication and delivery of and clinical outcomes. goal-concordant patient care. “As “Traditionally, hospitals have not been measured on accessibility of care,” Dr. Cooper explains. “But if Improving the Patient’s you provide high-quality care to a Surgical Experience very narrow sliver of the population, you’re not providing high-quality Dr. Cooper sees opportunity to care at all.” In collaboration with leverage the CSPH’s previous work the ACS, CSPH researchers are on serious illness care in surgery developing disparities-sensitive and continue to grow in those areas, metrics for surgical care access, including pursuing grants to study quality and outcomes that can surgical outcomes in patients with BWH DOS 31

dementia, using advanced care Using the TRICARE database of Expanding Cancer/ planning with surgical patients U.S. military members and their Oncology Initiatives and identifying and mitigating families and metrics endorsed caregiver burden through preemptive by the National Quality Forum, Dr. Cooper sees a chance to counseling and education. Muhammad Ali Chaudhary, MD, diversify the CSPH work from and Eric Goralnick, MD, examined predominantly trauma care research “It is incredibly important to think racial differences in specific aspects into other key areas in surgery, such about the impact of illness on our of surgical care quality following as building upon the work of CSPH patients’ lives,” she explains. “We a coronary artery bypass graft faculty Quoc Dien-Trinh, MD, and tend to treat the disease and not (CABG). Their study, published in Nelya Melnitchouk, MD, in cancer the illness as experienced by the Health Affairs in August 2019, found surgery. patients.” For example, a broken bone no risk-adjusted differences in the causes pain and loss of function and outcomes between African American “This is an area of increasing can have social, psychological and and white patients, suggesting that importance and opportunity,” spiritual impacts, especially on older universal insurance and an equal- Dr. Cooper says. “Most thoracic, adults. “There remains a lot of work access system of TRICARE have the colorectal, breast and endocrine to be done in surgery to address the potential to meaningfully reduce surgery is performed to treat cancer. way we can improve the patient’s racial disparities in surgical quality We have an opportunity to engage illness experience,” Dr. Cooper says. after a CABG. more faculty who are surgical oncologists doing great work on Collaborating with the U.S. Research led by Joel Weissman, disparities in cancer care and Military Health System PhD, deputy director and chief comparative research.” scientific officer at CSPH, used “We have a robust partnership the TRICARE database to identify Far-Reaching Impact with the U.S. Military Health significant differences in overuse System, and we are committed of low-value care between care “Our mission is to make surgery to continuing and strengthening delivered in civilian health care that relationship,” Dr. Cooper facilities (purchased care) and care better all around the world,” Dr. says. Through this multiyear, delivered in Department of Defense- multimillion- dollar grant, controlled health care facilities (direct Cooper says. “We leverage and researchers from the CSPH and care). Such research using large the Uniformed Services University administrative databases to identify capitalize on the rich resources that of the Health Sciences are able to potentially low-value care could help study health care policy issues of health systems provide better care at we have at the Brigham, in terms of importance to the U.S. military. a lower cost. brain power and the rich intellectual environment, and bring what we have to the world ªto make surgery safer and better.” Zara Cooper and Elzerie De Jager lead a discussion with the CSPH team.

CENTER FOR SURGERY AND PUBLIC HEALTH (CSPH) Making surgery safer, more patient-centered, and more accessible in the U.S. and around the world. Founded in 2005 as a joint initiative of Brigham and Women’s Hospital, Harvard Medical School and the Harvard T.H. Chan School of Public Health, the Center for Surgery and Public Health (CSPH) has been at the forefront of public health research of surgical care delivery within and without our nation’s healthcare system. Utilizing innovative research methodologies grounded in clinical reality, the center has developed surgical safety checklists, created a national agenda for surgical disparities research, and launched the pioneering work of rising stars in surgical health services research. They are advancing the science of surgical care delivery by studying effectiveness, quality, equity and value at the population level and training the most gifted of a new generation of physician-scientists. Their efforts are making surgery safer, more patient-centered and more accessible in the U.S. and around the world. 7 148 12 Peer-Reviewed Active Fellows Fellows Graduated Publications Published $5,224,783 In New Grant Awards National Palliative Care NIH R01 Supplement: National Trauma Institute: Research Center Grant: Barriers and Facilitators of ACP Developing a National Trauma The Trauma Dyad: Tending to Services by Patients with ADRD Research Action Plan (NTRAP) for Caregivers of Injured Frail Elders (Alzheimer’s Disease and Related the United States $486,723 $154,000 Dementias) Before and After Surgery $475,409 BWH DOS 33

Alliance U.S. member sites include 46 Academic Medical Centers and 72 Community Health Systems. Alliance Foundation Trials are also underway in seven other countries: Australia, Austria, Canada, France, Germany, Italy and Spain. A total of 52 Alliance-led therapeutic clinical trials are currently enrolling patients with a range of cancers: GI tract, breast, lung, GU tract, brain, leukemia, lymphoma, myeloma, endocrine and skin. Alliance research also continues to be active in areas of biomarker development, cancer prevention, cancer care delivery research, outcomes research, health disparities and symptom intervention. New Alliance initiatives in the past year include working groups focusing on rural sites and value of care. In 2020 Alliance will launch the ICAREdata initiative, a project to facilitate clinical research using the electronic health record. ª Monica Bertagnolli, MD, has been re-elected to serve as the group chair of the Alliance for Clinical Trials in Oncology for a five-year term. 34 BWH DOS

PATIENT REPORTED OUTCOMES, VALUE AND EXPERIENCE (PROVE) CENTER To leverage leading-edge techniques to transform the collection, analysis and feedback of patient-reported outcomes and experiences at Brigham Health, Partners HealthCare and around the world. YEAR AT A GLANCE The center expanded its support to INSPiRES Innovative System for seven members of the Brigham Surgery Patient-Reported Experience in The imPROVE Breast Cancer Care faculty, two residents and four students Surgery - In response to expensive, biased project initiated in collaboration with the from Harvard Medical School and Harvard and difficult to understand reports from Division of Breast Surgery, Dana-Farber Business School (HMS/HBS). The center quantitative surveys of patient experience Cancer Institute Oncology and the Harvard also supported applications from two PhD of care, the center successfully developed a Business School. candidates at the University of Oxford and new machine learning-enhanced platform, a Fulbright Scholar from Imperial College funded by the Brigham Care Redesign Innovative Systems for Patient- London. ª Incubator Startup Program (BCRISP), which Reported Experience in Surgery can collect and report patient experiences (INSPiRES) were supported by the Brigham KEY INITIATIVES to facilitate evidence-based improvement Care Redesign Incubator Startup Program initiatives within the Department of (BCRISP) and deployed across all divisions imPROVE Breast Cancer Care - Using Surgery (DoS). to assess patient experience using an in- a multi-stakeholder approach, Andrea L. house application. Pusic, MD, MHS, FACS, FRCSC, Tari King, Measuring Patient-Reported Outcomes MD, and team are leading an initiative to in Bariatric Surgery (The BODY-Q) - In The PROVE center partnered with the develop and implement a new electronic close collaboration with the Brigham Brigham Center for Metabolic and Bariatric portal called imPROVE Breast Cancer Care Center for Metabolic and Bariatric Surgery Surgery (CMBS) to develop a new bariatric to revolutionize the way patient-reported (CMBS), Danny Mou, MD, and Claire de surgery patient-reported outcome measure outcomes (PROs) are measured and learn Vries have established a program to recruit (PROM) instrument, the BODY-Q. how this information is used by clinicians bariatric surgery patients at the Brigham and patients in breast cancer care. The and at Brigham and Women's Faulkner The center collaborated with Partners imPROVE project is being conducted in Hospital (BWFH) to validate a rigorous HealthCare PROMs team to survey and collaboration with breast cancer care bariatric PROM instrument known as the interview physicians of various specialties providers at Brigham and Women’s BODY-Q: Eating Modules. This new tool across the Partners Healthcare system Hospital, Dana-Farber Cancer Institute uses the Rasch Measurement Theory and understand how PROMs are used in a (DFCI), patients and patient advocates, (RMT) principle, which unlike all existing clinical setting. members of Harvard Business School and bariatric PROMs, provides interval level the International Consortium for Health measurement scales and allows for Thirty-nine papers were published in Outcomes Measurement (ICHOM). The optimization of validity and reliability in journals including Annals of Surgery, JAMA new portal will include patient-facing individual patients. To date, over 300 Surgery, Plastic and Reconstructive Surgery, and clinician-facing interfaces that will be patient PROMs have been collected from Quality of Life Research and the Journal of developed with iterative cycles of feedback clinic. This is part of an international effort Medical Research. from patients and experts. This will ensure along with the Netherlands and Denmark to that each portal is both user-friendly and validate this novel PROMs tool. Extramural funding was accepted from contains content that is appealing to each the National Cancer Institute (NCI); Patient- group. To date, the team has developed Additionally, PROMs data collected Centered Outcomes Research Institute a comprehensive plan for the new portal, from this initiative is being compiled in a (PCORI); Agency for Healthcare Research and over the upcoming year, they will database that will be used to investigate and Quality (AHRQ); Canadian Institutes work closely with their IT vendor and key a number of bariatric surgery-related of Health Research (CIHR); and The Plastic stakeholders to refine the content of the questions, such as patient-reported Surgery Foundation (The PSF). portal and test its usability. differences between sleeve gastrectomies (SG) and roux-en-y gastric bypasses (RYGB); Invitations were received to present the effect of race, insurance status and PROVE research at 25 local, national and international meetings. BWH DOS 35

education on PROMs; and characteristics NEW PROJECTS that predict a successful bariatric surgical LAUNCHED outcome. Scaling and Spreading Electronic Collaboration with Partners HealthCare Capture of Patient-Reported Outcomes PROMs Team to Understand the Using a National Surgical Quality Physician’s Perspective of PROMs - In Improvement Program (NSQIP) - collaboration with the Partners HealthCare Incorporating the patient’s perspective PROMs team and the Massachusetts to evaluate surgical quality has yet to be General Physicians Organization (MGPO), achieved in the U.S. and represents a Dr. Mou has led an extensive survey and tremendous unrealized opportunity for interview campaign with physicians across continuous quality improvement. This the Partners HealthCare system to better project aims to scale and spread the understand how PROMs are precisely used routine, health IT-enabled collection of in the clinical setting. To date, over 100 PROs from ambulatory surgical patients physicians have been surveyed and over 50 using a well-established national surgical physicians interviewed. Physicians include quality improvement registry program. primary care physicians, rheumatologists, Results of this research will accelerate orthopedic surgeons, otolaryngologists and the uptake of using PROs for quality bariatric surgeons. Breast surgeons and improvement across the U.S., identify plastics surgeons will be interviewed in the best practices for implementation of such near future. a program and explore whether PROs can reliably identify quality improvement The findings have been presented to opportunities. This is a $1.5 million AHRQ multiple Partners key stakeholders from the R18 grant for which Dr. Pusic will serve Partners PROMs team, Partners Population as co-PI with Clifford Y. Ko, MD (American Health team, MGPO executive leadership, College of Surgeons), and Larissa Temple, and the Massachusetts General Hospital MD (University of Rochester Medical (MGH) Division of General Internal Medicine. Center), for this study. ª The data has been used by the Partners PROMs leadership team to meaningfully ADDITIONAL PROJECTS change critical components of the Partners PROMs program, including modifying the Understanding Patient-Reported data display in the electronic health record Outcomes in Older Adults Undergoing system to better highlight concerning PROM Elective Surgery. findings. ª Development and Implementation of ADDITIONAL PROJECTS a Patient-Reported Outcome Measure for Gender-Affirming Treatments Measuring Outcomes and Experiences (GENDER-Q). of Chronic Wound Patients (The WOUND-Q). Evaluating Cold Sensitivity Following Autologous vs. Implant-Based Breast Measuring Breast Sensation after Reconstruction Using Patient-Reported Mastectomy and Reconstruction: Outcomes and Infrared Thermal Development of New BREAST-Q Scales. Imaging. Improving Efficiency of Patient-Reported Understanding Success of Vascularized Outcome Measurement with Computer- Composite Allograft Transplant of the Adaptive Testing (CAT). Face from the Patient Perspective: Development of a Condition-Specific Improving Access to PROM Data Patient-Reported Outcome Measure. and Linkage to Clinical Variables: Collaboration with the Division of Urology. NCI Cancer Moonshot Initiative to Assess the Implementation of Epic-Integrated Symptom Assessment Tools to Monitor Surgical Oncology Patients. 36 BWH DOS

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News & Notes New Endowed Chair Stanley W. Ashley, MD served as chair Laura Dominici, MD was named Ravindra Uppaluri, of the board of trustees for the Society a member of the Organisation MD, PhD for Surgery of the Alimentary Tract for Economic Co-operation and (SSAT); was appointed to the Executive Development (OECD) as part of a group BWH Distinguished Chair in Committee of the Massachusetts focusing on breast cancer care under Otolaryngology, Brigham and Chapter of the American College of the coordination of the Working Party Women’s Hospital Surgeons (MCACS); and was appointed on Health Care Quality and Outcomes to the editorial board of PLOS One. (HCQO); and served as chair for the Faculty Promotions revision of the Commission on Cancer Monica Bertagnolli, MD has been (CoC) Quality Standards of the American Professor re-elected to serve as the group College of Surgeons (ACS). Andrea L. Pusic, MD, MHS chair of the Alliance for Clinical Chandrajit P. Raut, MD, MSc Trials in Oncology for a five-year Mehra Golshan, MD, MBA received term. She has served as Alliance an MBA from the MIT Sloan School of Associate Professor group chair since 2011. Management; served as a member Matthew T. Menard, MD of the board of directors for the Malcolm K. Robinson, MD Katherina Zabicki Calvillo, MD has National Accreditation Program for Prem S. Shekar, MD been selected to serve as program Breast Centers (NAPBC); served as the Quoc-Dien Trinh, MD chair for the American Society of Breast Corporate Relations Committee chair for Jiping Wang, MD, PhD Surgeons (ASBrS) Annual Meeting in the Society of Surgical Oncology (SSO); 2020. and was honored by the Healthnetwork Assistant Professor Foundation with a Service Excellence Reza Askari, MD Nancy L. Cho, MD was nominated Award. George Haleblian, MD associate chair of the Communications Ciaran McNamee, MD, MSc Committee for the Society of Asian Kamal Itani, MD was a visiting Nelya Melnitchouk, MD, MSc Academic Surgeons (SAAS); and was professor in the Department of Surgery Matthew Mossanen, MD, MPH elected to the Education Committee for at Yale School of Medicine; received the Erika L. Rangel, MD, MS the American Association of Endocrine Distinguished Service Award from the Assunta De Rienzo, PhD Surgeons (AAES). Association of VA Surgeons (AVAS); and Anna Weiss, MD was granted an honorary fellowship Abby White, DO Zara Cooper, MD, MSc was named from the Brazilian College of Surgeons the next Kessler Director of the (Colégio Brasileiro de Cirurgiões). Brigham Center for Surgery and Public Health (CSPH); was appointed Molly Jarman, PhD, MPH was to the Brigham Health Board of appointed lead research faculty Trustees; and was inducted into the for Health Informatics and Data Society of University Surgeons (SUS). Infrastructure in the Brigham Center for Surgery and Public Health (CSPH); Eduardo Corrales, MD was recognized and was selected to participate in the with the Harvard Medical School National Institute on Aging (NIA) Butler- (HMS) William Montgomery Teaching Williams Scholars Program. Award. This award is given yearly by the graduating chief residents Tsuyoshi Kaneko, MD was awarded in otolaryngology to recognize the J. Maxwell Chamberlain Memorial an outstanding teacher from all Paper Award from the Society of rotation sites including the Brigham, Thoracic Surgeons (STS) and the Massachusetts Eye and Ear (MEE), C. Walton Lillehei Award from the Beth Israel Deaconess Medical Center American Association for Thoracic (BIDMC) and Boston Children's Hospital Surgery (AATS). (BCH). Adam S. Kibel, MD served as the Gerard M. Doherty, MD began terms John R. Caulk Visiting Professor at serving as treasurer of the International Washington University School of Society of Surgery (ISS) and as the Medicine in St. Louis. historian for the Society of Clinical Surgery. 38 BWH DOS

Tari A. King, MD was named chief of the C. Keith Ozaki, MD participated in Ali Tavakkoli, MD co-edited the SAGES new Brigham Division of Breast Surgery; a surgical training mission to Jamaica Manual of Foregut Surgery; was installed served as member of the Steering (University Hospital of the West Indies as a fellow of the American Surgical Committee for the American Association and Mandeville Regional Hospital) Association (ASA); and was named chair for Cancer Research (AACR) Cancer sponsored by the nonprofit Bridge of Life of the Scholarships Committee of the Progress Report; was elected chair of the (BOL). American College of Surgeons (ACS). American Society of Clinical Oncology (ASCO) Taxonomy Committee. Mark A. Preston, MD, MPH received Nathaniel Treister, DMD, DMSc was the Prostate Cancer Research Program appointed as adjunct faculty at the Sayeed K. Malek, MD was appointed (PCRP) Health Disparity Research University of Zagreb School of Dental program director for both the Harvard Award from the Department of Defense Medicine in Zagreb, Croatia; and was Medical School (HMS) Surgical Congressionally Directed Medical reappointed as distinguished adjunct Leadership Program and Southeast Asia Research Programs (CDMRP). faculty in the Department of Oral Leadership Program (SEAL). Medicine and Radiology at Saveetha Andrea Pusic, MD was installed as Dental College in Chennai, India. Nelya Melnitchouk, MD, MSc has the president of The Plastic Surgery been named the program director of the Foundation (The PSF), which supports Stefan Tullius, MD, PhD was appointed Brigham colorectal surgery fellowship the research and international activities vice president of the International program. of the American Society of Plastic Society of Uterus Transplantation (ISUTx); Surgeons (ASPS). and was named an official representative Matthew T. Menard, MD served of The Transplantation Society (TTS) to as councilor-at-large and Program Erika L. Rangel, MD, MS received the the World Health Organization (WHO). Committee chair on the Executive Partners Medical Education Research Council of the New England Society of Award in recognition of her study, Alessandro Villa, DDS, PhD, MPH has Vascular Surgery (NESVS); served on the “Pregnancy and Motherhood During been named a spokesperson on HPV and Program Committee, Clinical Research Surgical Training,” published in JAMA oropharyngeal cancer for the American Committee and Appropriateness Surgery. Dental Association (ADA). Committee for the Society for Vascular Surgery (SVS); and was a visiting Chandrajit Raut, MD was the recipient Anna C. Weiss, MD was awarded the professor at San Giovanni di Dio Hospital of the Dana-Farber Cancer Institute Brigham Department of Surgery Junior in Florence, Italy. (DFCI) Bridging Boundaries Award. Fellowship in honor of Robert T. Osteen; and won the best manuscript award from Elizabeth A. Mittendorf, MD, PhD Robert Riviello, MD, MPH was the Association of Women Surgeons was elected to a four-year term as the inducted as a fellow in the College of (AWS)/The American Journal of Surgery Surgical Oncology representative on the Surgeons of East, Central and Southern (AJS). American Society of Clinical Oncology Africa (COSECSA). (ASCO) board of directors; was installed Joel Weissman, PhD has been invited as a fellow of the American Surgical Ali Salim, MD was appointed associate to serve as associated faculty for the Association (ASA); and was appointed chair of Surgical Critical Care in the new Center for Integrated Healthcare associate chair for Research in the Department of Surgery; and was Data Research, an initiative funded by Department of Surgery. appointed to the Partners HealthCare Partners HealthCare (PHC) to build a Board of Directors. data infrastructure that hosts and links Melissa Murphy, MD, MPH was the electronic health records from PHC named director of Surgical Quality and Prem S. Shekar, MD was named by to a variety of long-term outcome data Operations at Kent Hospital. Governor Charles Baker to serve as a sources, including multiple claims data board member on the Massachusetts and national mortality data. Matthew A. Nehs, MD was awarded Board of Registration of Perfusionists. the 2019 ThyCa: Thyroid Cancer Jeremy M. Wolfe, PhD was elected as Survivor’s Association Award for Thyroid Brent Shoji, MD received the Harvard member of the American Academy of Cancer Research. Medical School (HMS) Leonard Tow Arts and Sciences. Humanism in Medicine Award. Louis L. Nguyen, MD, MPH, MBA was Steven Yule, PhD was installed as a appointed associate chair for Digital Douglas S. Smink, MD, MPH received fellow of the Royal College of Surgeons of Health Systems in the Department of a 2019 Parker J. Palmer Courage to Edinburgh. Surgery. Teach Award from the Accreditation Council for Graduate Medical Gezzer Ortega, MD, MPH was Education (ACGME). appointed lead faculty for Research and Innovation for Equitable Surgical Care in the Brigham Center for Surgery and Public Health (CSPH); and co-founded the Latino Surgical Society (LSS). BWH DOS 39

top docs Boston Magazine’s 2019 “Top Doctors” issue recognized 46 Department of Surgery faculty members for being “tops” in their respective fields: Donald J. Annino Jr., MD • Otolaryngology Hari R. Mallidi, MD • Thoracic & Cardiac Surgery Stanley W. Ashley, MD • Surgery Michael J. Malone, MD • Urology Michael Belkin, MD • Vascular Surgery Matthew T. Menard, MD • Vascular Surgery Monica M. Bertagnolli, MD • Surgery Steven J. Mentzer, MD • Thoracic & Cardiac Surgery Ronald Bleday, MD • Colon & Rectal Surgery Francis D. Moore Jr., MD • Surgery Raphael Bueno, MD • Thoracic & Cardiac Surgery Faina Nakhlis, MD • Surgery Katherina Zabicki Calvillo, MD • Surgery Michael P. O’Leary, MD • Urology Matthew J. Carty, MD • Plastic Surgery Dennis P. Orgill, MD • Plastic Surgery Steven Lee Chang, MD • Urology Charles K. Ozaki, MD • Vascular Surgery Yoon Sun Chun, MD • Plastic Surgery Bohdan Pomahac, MD • Plastic Surgery Thomas Clancy, MD • Surgery Andrea Pusic, MD • Plastic Surgery Christian H. Corwin, MD • Colon & Rectal Surgery Chandrajit P. Raut, MD • Surgery Gerard M. Doherty, MD • Surgery Esther Rhei, MD • Surgery Christopher Ducko, MD • Thoracic & Cardiac Surgery Christian E. Sampson, MD • Hand Surgery Margaret M. Duggan, MD • Surgery Scott A. Shikora, MD • Surgery Atul A. Gawande, MD • Surgery Douglas Smink, MD • Surgery Joel E. Goldberg, MD • Colon & Rectal Surgery Graeme S. Steele, MD • Urology Mehra Golshan, MD, MBA • Surgery Scott J. Swanson, MD • Thoracic & Cardiac Surgery Charles A. Hergrueter, MD • Plastic Surgery Simon G. Talbot, MD • Plastic Surgery Pardon R. Kenney, MD • Surgery Ali Tavakkoli, MD • Surgery Adam S. Kibel, MD • Urology Ashley H. Vernon, MD • Surgery Tari A. King, MD • Surgery Jon O. Wee, MD • Thoracic & Cardiac Surgery Sayeed K. Malek, MD • Surgery Daniel C. Wiener, MD • Thoracic & Cardiac Surgery The following board-certified Brigham Oral Medicine specialists were included in Boston Magazine’s “Top Dentists 2019” list: Nathaniel Treister, DMD, DMSc • Stephen Sonis, DMD, DMSc • Sook-Bin Woo, DMD, MMSc 40 BWH DOS

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Development Mitchell’s $1 Million effective care and the promise of a brighter memories of watching her employees’ Gift Sustains future for patients with lung cancer. careers bloom under her guidance. Thoracic Cancer Fellowship “Through mentorship there is “Nothing could be more meaningful partnership and through partnership than sponsoring someone who can make a “My dream is to live in a world where lung there is innovation,” Dr. Jaklitsch says. “It difference in people’s lives,” she says. “It’s cancers no longer kill and are merely an is through Jack’s incredible support that wonderful to think of these fellows going awful chapter in our history,” Michael more of the brightest young physicians are out into the world and bringing their skills T. Jaklitsch, MD, a thoracic surgeon at choosing this area of care and cultivating to serve hospitals and patients in need, or Brigham and Women’s Hospital, says. “Until innovation through the research efforts to labs working to find a cure. It feels good that day arrives, I want the best doctors to they pursue, all for the patients we are to be part of change and progress.” ª enter the field of thoracic surgery, come to privileged to treat.” ª the Brigham, and make a commitment and Lorussos Fight for promise to our patients that this future is Gelsomini Invests in Future Free from in sight.” Young Surgeons Breast Cancer More than 11 years ago, Jaklitsch’s Though she retired this year after spending For Barbara Lorusso, breast cancer has vision caught the attention of his patient 20 years building her global footwear been a tenacious foe. She has dealt with John D. Mitchell. He was moved when company, Ortholite, Pamela Gelsomini seven recurrences in the past 25 years, Jaklitsch shared that the most valuable is hardly resting. She is busy with family, each time relying on the guidance of part of his training was his fellowship, travel, cooking and writing award-winning caregivers at the Comprehensive Breast which immersed him in rigorous classwork recipes on her culinary blog, Dish Off the Health Center. and meaningful clinical and research Block. experience. “They’ve always been there for me,” As a nine-year breast cancer survivor, Barbara says. “I can’t say enough about Mitchell imagined how his philanthropy Gelsomini takes none of her days for my doctors’ devotion to responding to could bring this educational opportunity to granted. She is full of gratitude to her my concerns. They’ve been clear and young lung cancer physician-scientists and breast cancer surgeon at Brigham and informative, even when it’s not news I’ve decided then and there to establish the Women’s Hospital, Mehra Golshan, MD, wanted to hear.” John D. Mitchell Thoracic Oncology Surgical MBA, whom she credits for giving her life Fellowship at the Brigham. Since making back. Inspired by him, Gelsomini became Touched by the support Barbara has that initial gift, Mitchell continued building a benefactor of Golshan’s lifesaving work received, she and her husband, Tony, on his support over time and recently and joined the Brigham’s Cancer Research have made steady contributions over the pledged $1 million to the fellowship. and Care Advisory Board. years to advance the center’s caring and research missions. Recently, they made “It’s gratifying to watch fellows come up Recently, she and her husband, Nick, their largest commitment to date, giving through the program who share qualities made their largest gift to date, pledging $100,000 to research led by Peggy Duggan, I admire,” Mitchell says. “They’re intensely $450,000 to establish the Pamela and MD, Barbara’s surgeon and the chief curious and highly skilled, compelled to Nick Gelsomini Breast Surgical Oncology medical officer at Brigham and Women’s pursue answers to the toughest questions Fellowship at the Brigham. Directed by Faulkner Hospital. and devote their careers to developing Golshan, the program will enable talented solutions to improve patients’ treatment trainees to learn from his knowledge, skill By establishing the Barbara Lorusso options and survival. It’s no coincidence and compassion. Breast Cancer Research Fund, the Dr. Jaklitsch embodies these same Lorussos are giving Duggan vital resources characteristics. It is a wonderful thing to “Dr. Golshan is an icon, and I have to study and improve methods of detecting see him develop them in a new generation so much respect and admiration for breast cancer, including genetic screening of lung cancer experts.” everything he does, from surgery, to and non-invasive options. research, to nurturing up-and-coming Jaklitsch is grateful that Mitchell’s surgeons,” Gelsomini says. “It is so exciting “We’re doing this for everyone we know foresight and generosity will allow him to know someone of his caliber is guiding who has lived with cancer,” Tony says. “Even to expand the fellowship—empowering and training these fellows, who come to with what Barbara has been through, life creative approaches to yield new the Brigham to learn from the best.” has been good to us. We feel an obligation treatments and technologies, more to give back in any way we can, especially if Gelsomini says she can relate to the there’s a chance to spare more women and power of opportunity and mentorship to families from this disease.” ª shape a better future. She has many proud 42 BWH DOS

Support the Work Leadership of the Department of Surgery Gerard M. Doherty, MD Moseley Professor of Surgery, Harvard Medical School Each year, thousands of people entrust the Surgeon-in-Chief, Brigham Health & Dana-Farber Cancer Institute Department of Surgery at Brigham Health Crowley Family Distinguished Chair, Department of Surgery, to provide them with excellent medical Brigham and Women’s Hospital care. Many turn to us because of our long history of medical firsts and reputation Francis D. Moore, Jr., MD for attracting the finest surgical trainees Vice Chair, Department of Surgery, Brigham and Women’s Hospital and surgeons in the country. One of the Francis D. Moore Professor of Surgery, Harvard Medical School reasons we have been able to build such a strong program—and to establish new Ronald Bleday, MD standards of surgical care—is because of Associate Chair for Quality and Patient Safety philanthropic contributions from people like you. Zara Cooper, MD, MSc Associate Chair for Faculty Development Gifts from our alumni, patients and friends help us to train our staff in the Tari A. King, MD latest surgical techniques, to make Associate Chair for Multidisciplinary Oncology advances in surgery through research and to achieve the best possible outcomes Elizabeth Mittendorf, MD, PhD for patients. When you make a gift to Associate Chair of Research the Department of Surgery, you enable our medical team to provide the most Louis L. Nguyen, MD, MPH, MBA advanced care and make a difference for Associate Chair for Digital Health Systems every patient and family member we see. Malcolm K. Robinson, MD For more information if you are Associate Chair of Clinical Operations interested in making a gift to the Department of Surgery at Brigham Ali Salim, MD and Women’s Hospital, or to a specific Associate Chair of Surgical Critical Care physician or scientist within the department, please contact Susan Douglas S. Smink, MD, MPH Andrews, assistant vice president, Associate Chair of Education Development Office, at 617.424.4349 or [email protected]. ª Contact Us Brigham Surgery Department of Surgery Alumni 75 Francis Street Tower 1 – Room 110 The BWH Surgery Alumni Group consists Boston, MA 02115 of graduates of Brigham and Women’s [email protected] Hospital surgery residency and fellowship 617.732.8181 programs and former Department of Surgery faculty members. Follow Us If you would like to join the BWH Surgery twitter.com/bwhsurgery Alumni Group and receive news and brighamandwomens.org/surgery updates from the Department of Surgery, please visit: bwhsurgerynews.partners.org/alumni or email us at: [email protected]. ª stay in touch!

Brigham Surgery is committed to delivering world-class, collaborative patient care with a profoundly human touch, while advancing scientific research and training the surgical innovators of tomorrow. brighamandwomens.org/surgery

Department of Surgery 2018 ANNUAL REPORT

DEPARTMENT OF SURGERY by the numbers 41 176 5 fellows faculty ACGME-accredited surgical fellowships 4 30,314 operations performed ACGME-accredited surgical residency programs 435 11 111 research funds clinical divisions interns and residents 47 121,227 office visits research fellows $33,005,959 research spending

A Letter from the Chair 2 For over a century, Brigham and Women’s Hospital and its predecessors 0 have made incredible contributions to advance the field of surgery, 1 in large part due to the people who have been drawn to come to our 8 campus to work. Everyday our surgeons and teams deliver world- class collaborative patient care while advancing scientific research and A training the surgical innovators of tomorrow. N That has led to many things having been done for the first time N at Brigham and Women’s Hospital, such as kidney transplantation, U numerous heart valve procedures and many initiatives that are unique to our Department A in terms of implementation of standard practices – from improving the health care in areas L beyond our borders, to providing transplantation services that can restore function not just of internal organs but of the face, hands and arms, to clinical trials in cancer that are among the R most advanced in the world. While these firsts are certainly noteworthy, I am most proud to be E part of a Department of Surgery with a lengthy tradition of perfecting care by making it safer P and more effective – not just doing it first, but doing it best. O R Over the past year, the Department of Surgery has continued to build on our proud T history of clinical and academic achievement. We saw our faculty continue to grow as we welcomed the following new members to our group: Elodi J. Dielubanza, MD, Urology; Chris Gibbons, PhD, Patient-Reported Outcomes, Value & Experience Center; Lydia A. Helliwell, MD, Plastic Surgery; Lindsey M. Korepta, MD, Vascular and Endovascular Surgery; Elizabeth A. Mittendorf, MD, PhD, Surgical Oncology; Andrea L. Pusic, MD, MHS, Plastic and Reconstructive Surgery; and Anna C. Weiss, MD, Surgical Oncology. We also named two new divisional leaders this academic year. Andrea L. Pusic, MD, MHS, was named chief of Plastic and Reconstructive Surgery and Ravindra Uppaluri, MD, PhD, was named chief of Otolaryngology – Head and Neck Surgery. Our Department continues to be on the cutting edge of surgical research with new grant funding to study cultural dexterity curriculum for surgeons, disparities-sensitive surgical quality metrics and to develop fundamentally new surgical approaches to extremity amputation. Our recently launched Breast Cancer Personalized Risk Assessment, Education and Prevention (B-PREP) Program is an excellent model of effective multidisciplinary clinical care and the newly formed Patient-Reported Outcomes, Value & Experience (PROVE) Center will focus on patient-reported outcomes, patient experience and value-based surgery throughout all surgical disciplines at our institution and beyond. This annual report highlights just some of the many examples of our ongoing commitment to excellence in clinical care, research and surgical education. Thank you for taking the time to read our report, we look forward to connecting with you again soon. GERARD M. DOHERTY, MD Moseley Professor of Surgery, Harvard Medical School Surgeon-in-Chief, Brigham Health & Dana-Farber Cancer Institute Crowley Family Distinguished Chair, Department of Surgery, Brigham and Women’s Hospital BWH DOS 3

Faculty DEPARTMENT OF SURGERY Brigham and Women’s Hospital attracts internationally renowned surgeons who create pioneering breakthroughs that make a difference for patients today as well as for generations to come. We are committed to delivering world-class, collaborative patient care with a profoundly human touch, while advancing scientific research and training the surgical innovators of tomorrow. Division of DIVISION OF GENERAL AND GASTROINTESTINAL SURGERY Cardiac Surgery FRANCIS D. MOORE, JR., MD Chief • Division of General and Gastrointestinal Surgery Vice Chair • Department of Surgery Francis D. Moore Professor of Surgery PREM S. SHEKAR, MD Endocrine Colon and Chief • Division of Cardiac Surgery Rectal Surgery Surgery Assistant Professor of Surgery FRANCIS D. MOORE, JR., MD RONALD BLEDAY, MD Section Chief • Endocrine Surgery Section Chief • Colon Sary F. Aranki, MD Francis D. Moore Professor of Surgery and Rectal Surgery Associate Professor of Surgery Associate Professor of Surgery Nancy L. Cho, MD Tsuyoshi Kaneko, MD Assistant Professor of Surgery Christian H. Corwin, MD Assistant Professor of Surgery Instructor in Surgery Gerard M. Doherty, MD Dan Loberman, MD Crowley Family Distinguished Chair Joel E. Goldberg, MD Instructor in Surgery Moseley Professor of Surgery Assistant Professor of Surgery Marc C. Pelletier, MD, MSc Atul A. Gawande, MD, MPH Jennifer L. Irani, MD Member of the Faculty of Surgery Cynthia and John F. Fish Assistant Professor of Surgery Distinguished Chair in Surgery Paul Pirundini, MD Samuel O. Thier Professor Nelya Melnitchouk, MD Instructor in Surgery of Surgery Instructor in Surgery James D. Rawn, MD Matthew A. Nehs, MD Melissa M. Murphy, MD, MPH Instructor in Surgery Assistant Professor of Surgery Instructor in Surgery Steve K. Singh, MD Member of the Faculty of Surgery 4 BWH DOS

MINIMALLY INVASIVE SURGERY (MIS) & GENERAL SURGEONS 2 0 Minimally Invasive Surgery (MIS) General Surgeons 1 8 Stanley W. Ashley, MD John J. Froio, MD Frank Sawyer Professor of Surgery Instructor in Surgery A N David C. Brooks, MD Pardon R. Kenney, MD, MMSc N Associate Professor of Surgery Senior Lecturer on Surgery U A Douglas S. Smink, MD, MPH Brent T. Shoji, MD L Associate Professor of Surgery Assistant Professor of Surgery R Edward E. Whang, MD E Associate Professor of Surgery P O R T Metabolic and Bariotric Surgery SCOTT A. SHIKORA, MD Section Chief • Metabolic and Bariatric Surgery Professor of Surgery Neil D. Ghushe, MD Instructor in Surgery Malcolm K. Robinson, MD Assistant Professor of Surgery Eric G. Sheu, MD, PhD Assistant Professor of Surgery David Spector, MD Instructor in Surgery Ali Tavakkoli, MD Associate Professor of Surgery Ashley H. Vernon, MD Instructor in Surgery Paul B. Davidson, PhD Instructor in Psychiatry Mark Gorman, PhD Instructor in Psychiatry BWH DOS 5

Division of Division of Otolaryngology– Division of Plastic and Oral Medicine Head and Neck Surgery Reconstructive Surgery NATHANIEL S. TREISTER, DMD, DMSc RAVINDRA UPPALURI, MD, PHD ANDREA L. PUSIC, MD, MHS Chief • Division of Oral Surgery Chief • Division of Division of Chief • Division of Plastic and Associate Professor of Oral Otolaryngology–Head and Neck Reconstructive Surgery Medicine, Infection, and Immunity Surgery Joseph E. Murray Professor BWH Distinguished Chair in of Surgery Vidya Snakar, DMD, MHS Otolaryngology Associate Professor of Otolaryngology Matthew J. Carty, MD Stephen T. Sonis, DMD, DMSc Associate Professor of Surgery Professor of Oral Medicine, Donald J. Annino, DMD, MD Infection, and Immunity Assistant Professor of Otolaryngology E.J. Caterson, MD, PhD Assistant Professor of Surgery Herve Y. Sroussi, DMD, PhD Neil Bhattacharyya, MD Associate Professor of Oral Professor of Otolaryngology Stephanie Caterson, MD, MSc Medicine, Infection, and Immunity Assistant Professor of Surgery Thomas L. Carroll, MD Alessandro Villa, DMD, MPH, PhD Assistant Professor of Otolaryngology Benjamin P. Christian, MD Assistant Professor of Oral Instructor in Surgery Medicine, Infection, and Immunity Carleton Eduardo Corrales, MD Instructor in Otolaryngology Yoon S. Chun, MD Sook-Bin Woo, DMD, MMSc Associate Professor of Surgery Associate Professor of Oral Medicine, Laura A. Goguen, MD Infection, and Immunity Associate Professor of Otolaryngology Jessica Erdmann-Sager, MD Instructor in Surgery Jason I. Kass, MD, PhD Instructor in Otolaryngology Lydia A. Helliwell, MD Instructor in Surgery Alice Z. Maxfield, MD Instructor in Otolaryngology Douglas L. Helm, MD Instructor in Surgery Anthony A. Prince, MD Instructor in Otolaryngology Charles A. Hergrueter, MD Assistant Professor of Surgery Rachel E. Roditi, MD Instructor in Otolaryngology Dennis P. Orgill, MD, PhD Professor of Surgery Jo Shapiro, MD Associate Professor of Otolaryngology Bohdan Pomahac, MD Roberta and Stephen R. Weiner Jennifer J. Shin, MD Distinguished Chair in Surgery Associate Professor of Otolaryngology Professor of Surgery Christian E. Sampson, MD Assistant Professor of Surgery Indranil Sinha, MD Assistant Professor of Surgery Simon G. Talbot, MD Associate Professor of Surgery

Division of Section of Surgical Oncology Breast Surgery MONICA M. BERTAGNOLLI, MD TARI A. KING, MD Mehra Golshan, MD Chief • Division of Surgical Section Chief • Breast Surgery Dr. Abdul Mohsen and Sultana Oncology Anne E. Dyson Associate Professor of Al-Tuwaijri Distinguished Chair in Richard E. Wilson Professor of Surgery Surgery in the Field of Women’s Cancers Surgical Oncology in the Field of Surgical Oncology Associate Professor of Surgery Thanh U. Barbie, MD Thomas E. Clancy, MD Instructor in Surgery Elizabeth Mittendorf, MD, PhD Assistant Professor of Surgery Robert and Karen Hale Distinguished Chandrajit P. Raut, MD, MSc Katherina Zabicki Calvillo, MD Chair in Surgical Oncology Associate Professor of Surgery Instructor in Surgery Associate Professor of Surgery Jiping Wang, MD, PhD Assistant Professor of Surgery Laura S. Dominici, MD Faina Nakhlis, MD Charles H. Yoon, MD, PhD Assistant Professor of Surgery Assistant Professor of Surgery Assistant Professor of Surgery Margaret M. Duggan, MD Suniti Nimbkar, MD Assistant Professor of Surgery Instructor in Surgery Esther Rhei, MD Assistant Professor of Surgery Anna Weiss, MD Member of the Faculty of Surgery Division of Christopher T. Ducko, MD Namrata Patil, MD, MPH Thoracic Surgery Assistant Professor of Surgery Instructor in Surgery RAPHAEL BUENO, MD Michael T. Jaklitsch, MD Scott J. Swanson, MD Chief • Division of Thoracic Professor of Surgery Professor of Surgery Surgery Fredric G. Levin Distinguished Chair in Abraham Lebenthal, MD, MHA Hisashi Tsukada, MD, PhD Thoracic Surgery and Lung Cancer Instructor in Surgery Instructor in Surgery Research Professor of Surgery Hari R. Mallidi, MD Jon O. Wee, MD Associate Professor of Surgery Assistant Professor of Surgery Yolonda L. Colson, MD, PhD Michael A. Bell Family Distinguished Ciaran McNamee, MD, MSc Brian Whang, MD Chair in Healthcare Innovation Instructor in Surgery Instructor in Surgery Professor of Surgery Steven J. Mentzer, MD Abby A White, DO Marcelo C. DaSilva, MD Professor of Surgery Instructor in Surgery Lecturer on Surgery Daniel C. Wiener, MD Instructor in Surgery BWH DOS 7

Division of Division of Trauma, Burn, Division of Urology Transplant Surgery Surgical and Critical Care STEFAN G. TULLIUS, MD, PHD ALI SALIM, MD ADAM S. KIBEL, MD Chief • Division of Transplant Chief • Division of of Trauma, Burn, Chief • Division of Urology Surgery Surgical and Critical Care Elliott Carr Cutler Professor of Professor of Surgery Professor of Surgery Surgery Sanjay Kumar, MD Reza Askari, MD Steven L. Chang, MD, MS Associate Professor of Surgery Instructor in Surgery Assistant Professor of Surgery Sayeed K. Malek, MD Christopher J. Burns, MD Elodi J. Dielubanza, MD Assistant Professor of Surgery Instructor in Surgery Member of the Faculty of Surgery Cristina Carpio, MD Jairam R. Eswara, MD Instructor in Surgery Assistant Professor of Surgery Jason E. Cohen, DO George Haleblian, MD Member of the Faculty of Surgery Zara R. Cooper, MD, MSc Associate Professor of Surgery Martin Kathrins, MD Instructor in Surgery David W. Fink, MD Instructor in Surgery Michael J. Malone, MD Instructor in Surgery Adil H. Haider, MD, MPH Member of the Faculty of Surgery Michael W. McDonald, MD Assistant Professor of Surgery Joaquim M. Havens, MD Assistant Professor of Surgery Michael P. O’Leary, MD, MPH Professor of Surgery Edward Kelly, MD Assistant Professor of Surgery Mark A. Preston, MD, MPH Assistant Professor of Surgery Deepika Nehra, MD Assistant Professor of Surgery Graeme S. Steele, MD Assistant Professor of Surgery Stephanie L. Nitzschke, MD, MS Instructor in Surgery Quoc-Dien Trinh, MD Assistant Professor of Surgery Erika L. Rangel, MD, MS Assistant Professor of Surgery Robert Riviello, MD, MPH Assistant Professor of Surgery Naomi Shimizu, MD Instructor in Surgery

Division of Vascular and Research Steven Piantadosi, MD, PhD Endovascular Surgery Senior Investigator Ann Marie Egloff, PhD, MPH MICHAEL BELKIN, MD Lead Investigator William G. Richards, PhD Chief • Division Vascular and Member of the Faculty of Surgery Lead Investigator Endovascular Surgery Assistant Professor of Surgery Professor of Surgery Chris Gibbons, PhD Lead Investigator Joel S. Weissman, PhD Garima Dosi, MD Member of the Faculty of Surgery Senior Investigator Edwin C. Gravereaux, MD Professor of Surgery Instructor in Surgery Li Jia, PhD Lead Investigator Jeremy M. Wolfe, PhD Lindsey Korepta, MD, RPVI Assistant Professor of Surgery Senior Investigator Edward M. Kwasnik, MD Professor of Ophthalmology Assistant Professor of Surgery Raouf A. Khalil, MD, PhD Lead Investigator Feng Yao, PhD Edward J. Marcaccio, Jr., MD Associate Professor of Surgery Lead Investigator Assistant Professor of Surgery Associate Professor of Surgery James A. Lederer, PhD Matthew T. Menard, MD Lead Investigator Associate Professor of Surgery Associate Professor of Surgery Louis L. Nguyen, MD, MBA, MPH Emeritus Cardiac Surgery Associate Professor of Surgery John A. Mannick, MD Miguel Haime, MD C. Keith Ozaki, MD Moseley Professor of Surgery, Emeritus Jacquelyn A. Quin, MD Professor of Surgery Marco Zenati, MD Anthony D. Whittemore, MD Marcus E. Semel, MD, MPH Professor of Surgery, Emeritus Plastic Surgery Instructor in Surgery Michael J. Zinner, MD Shahe Fereshetian, MD Samir K. Shah, MD Moseley Professor of Surgery, Emeritus Instructor in Surgery AFFILIATED FACULTY Urology South Shore Hospital B. Price Kerfoot, MD Frederick Millham, MD Vascular Surgery Chair of Surgery, South Shore Hospital Michelle C. Martin, MD Veteran’s Affairs (VA) Boston Joseph Raffetto, MD Healthcare System Research General Surgery Vivian Cristofaro, PhD Kamal Itani, MD Aldebaran Hofer, MD, PhD Chief of Surgery, VA Boston Health Jialan Shi, MD, PhD Care System Maryrose P. Sullivan, PhD P. Marco Fisichella, MD, MBA Jason S. Gold, MD Gentian Kristo, MD BWH DOS 9

Faculty NEW DIVISION CHIEFS ANDREA L. PUSIC, MD, MHS measures in surgery. member for 16 years before moving to Chief • Division of Plastic and Throughout her career, Dr. Pusic has Boston with his wife, Chitra Uppaluri, MD, Reconstructive Surgery and three children in 2016. Joseph E. Murray Professor of Surgery been involved in research studies that seek to better understand the patient Dr. Uppaluri, a leader in his field, has Andrea L. Pusic, MD, perspective on surgical outcomes and a deep understanding of head and neck MHS, was named the experiences. She is principal investigator tumor biology as well as integration of new chief of Plastic and of a study funded by the Patient-Centered radiation, chemotherapy and surgical Reconstructive Surgery Outcomes Research Institute (PCORI) that treatment modalities, including minimally at Brigham Health in examines how electronic patient-reporting invasive transoral laser microsurgery March of 2018. Prior of symptoms may improve surgical care. and endoscopic and open approaches to joining the Brigham, she was an Altogether, she has been a principal to anterior skull base pathologies. He attending plastic surgeon at Memorial investigator or co-principal investigator on has been the primary investigator of Sloan-Kettering Cancer Center (MSKCC) over $10 million in federal research grants. clinical trials integrating small molecule and a professor of surgery at Weill Medical and immunotherapeutics in the surgical College of Cornell University in New Dr. Pusic has authored over 200 scientific management of head and neck cancers. He York, NY. articles and book chapters and has also leads a National Institutes of Health Dr. Pusic completed her medical degree mentored more than 24 surgeons during (NIH) funded laboratory, focused on basic at the Cumming School of Medicine various stages of their academic careers. and translational approaches to head and (University of Calgary) in Canada and In 2017, she was awarded the Research neck cancers. ª master of public health at Johns Hopkins Achievement Award from the American University. She completed a general Society of Plastic Surgeons/Plastic Surgery NEW FACULT Y surgery residency at Dalhousie University in Foundation. Dr. Pusic is vice-president Nova Scotia, and a plastic surgery residency of WomenforWomen Reconstructive ELODI J. DIELUBANZA, MD at McGill University in Montreal, followed Surgery and regularly leads surgical camps Urology by a plastic and reconstructive surgery to provide reconstructive surgery for fellowship at MSKCC. injured women and girls in the developing Elodi J. Dielubanza, Dr. Pusic is an internationally-renowned world. She is a past board member of the MD, is a graduate of innovator and leader in the area of International Society of Quality of Life Columbia University patient-reported outcomes and surgical (ISOQOL) and is currently the president of in New York, NY and experience. This is increasingly important the Plastic Surgery Foundation. ª received her medical in the current health care environment degree from the David of measuring quality, assessing value and RAVINDRA UPPALURI, MD, PHD Geffen School of Medicine at UCLA in Los ultimately, influencing how health care Chief • Division of Otolaryngology Angeles, CA. She completed a Urology is funded. Dr. Pusic leads the Patient- –Head and Neck Surgery Residency at Northwestern University in Reported Outcomes, Value & Experience BWH Distinguished Chair in Otolaryngology Chicago, IL and a Female Pelvic Medicine (PROVE) Center at Brigham Health. The Associate Professor of Otolaryngology and Reconstructive Surgery Fellowship at scope of the PROVE Center is focused Cleveland Clinic in Cleveland, OH. on patient-reported outcomes, patient Ravindra Uppaluri, MD, Her clinical and research interests experience and value-based surgery in PhD, was named the new include a focus on female urology including: surgical patients throughout Brigham chief of Otolaryngology- vaginal surgery, urinary incontinence, Health. Head and Neck Surgery pelvic organ prolapse, overactive bladder, Dr. Pusic’s research focuses on the at Brigham Health in voiding dysfunction and pelvic floor measurement of quality of life and patient September of 2017. dysfunction. ª satisfaction in surgery. Dual training in He had served as an associate surgeon epidemiology and surgery has enabled her and director of Head and Neck Surgical to lead a team of experts in psychometrics, Oncology at the Dana-Farber/Brigham and quality of life and social science methods to Women’s Cancer Center since 2016. develop, validate and use new quantitative measures to assess patient outcomes. The Dr. Uppaluri completed his medical patient-reported outcomes instrument degree and doctorate in genetics at the she developed for breast surgery, the University of Minnesota in Minneapolis, BREAST-Q, has been widely adopted for MN. He trained in Otolaryngology at research and clinical care and serves as the Barnes-Jewish Hospital and the Washington basis for development of other outcome University School of Medicine in St. Louis, MO. He remained there as a faculty 10 BWH DOS

LYDIA A. HELLIWELL, MD completed a residency in General Surgery. initiated studies evaluating immune 2 Plastic Surgery After completing her residency, she served checkpoint blockade administered in 0 on active duty in the United States military the presurgical setting to breast cancer 1 Lydia A. Helliwell, before completing a fellowship in Surgical patients. 8 MD, is a graduate of Oncology at the University of Texas MD Massachusetts Institute Anderson Cancer Center in Houston, TX. Dr. Her laboratory work is focused on A of Technology in Boston, Mittendorf also holds a PhD in Immunology identifying novel tumor antigens and N MA and received her from the University of Texas Graduate investigating aspects of the tumor N medical degree from the School of Biomedical Sciences at Houston. microenvironment that impact the U University of Massachusetts Medical School response to immunotherapy. Specifically, A in Worcester, MA. She completed a Plastic Dr. Mittendorf is the inaugural Rob she is investigating mutations in the ESR1 L Surgery Residency in the Harvard Plastic and Karen Hale Distinguished Chair in gene as targets for vaccination as well Surgery Combined Residency Program and Surgical Oncology at Brigham and Women’s as the impact of standard therapies on R a fellowship in Orthopedic Hand Surgery at Hospital; the director of Surgical Research the immune microenvironment with the E Massachusetts General Hospital. at Dana-Farber/Brigham and Women’s goal of informing rational clinical trials P Her clinical and research interests Cancer Center (DF/BWCC) Breast Program; evaluating the addition of immunotherapy O include: hand surgery, peripheral nerve director of the Breast Immuno-Oncology to treatment regimens for breast cancer R surgery, microsurgery, lower extremity Program at Dana-Farber Cancer Institute patients. This work is supported by T reconstruction, brachial plexus injuries and and co-­director of the Breast Cancer the Komen for the Cure Foundation medical education. ª Clinical Research Program in the Breast and the Parker Institute for Cancer Oncology Program at Dana-Farber. Immunotherapy. ª LINDSEY M. KOREPTA, MD, RPVI Vascular and Endovascular Surgery Prior to joining Brigham and Women’s ANNA C. WEISS, MD Hospital and Dana-Farber Cancer Institute, Surgical Oncology Lindsey M. Korepta, MD, Dr. Mittendorf was a professor in the RPVI, is a graduate of the Department of Breast Surgical Oncology Anna C. Weiss, MD, University of Michigan at the University of Texas MD Anderson is a graduate of Case in Ann Arbor, MI and Cancer Center in Houston, TX. She joined Western Reserve completed her medical the faculty at MD Anderson in 2008. University School of degree at Michigan State Medicine in Cleveland, University College of Human Medicine Dr. Mittendorf is board certified by the OH. She completed a in East Lansing, MI. She completed her America Board of Surgery. She maintains General Surgery Residency at the University postgraduate training in the Spectrum a busy clinical practice and oversees a of California, San Diego School of Medicine Health/Michigan State University Integrated portfolio of clinical trials as well as a basic in San Diego, CA and a fellowship in Breast Vascular Residency Program in Grand laboratory effort. Surgical Oncology at the University of Rapids, MI. Texas MD Anderson Cancer Center in Her clinical and research interests She is principal investigator on a number Houston, TX. include: aortic aneurysm repair, of clinical protocols including the phase Her clinical interests include the surgical peripheral vascular disease and limb care III PRESENT (Prevention of Recurrence in treatment of breast cancer, axillary surgery preservation, arteriovenous fistula creation, Early-Stage, Node-Positive Breast Cancer and inflammatory breast cancer. Her venous insufficiency treatment and quality with Low to Intermediate HER2 Expression clinical research is focused on surgical improvement. ª with NeuVax Treatment) study, and a management of the axilla, inflammatory multicenter phase II trial investigating the breast cancer, large population database ELIZABETH A. MITTENDORF, MD, PHD efficacy of a CD8+ T cell eliciting vaccine research and the application and Surgical Oncology in combination with trastuzumab which is integration of collaborative clinical trial based on preclinical data generated in her results with real world data. Dr. Weiss is an Elizabeth A. Mittendorf, laboratory and follows a phase I trial she executive officer in the Alliance for Clinical MD, PhD, is a graduate conducted demonstrating the combination Trials in Oncology, including the PCORI of Case Western Reserve to be safe. This trial is supported by a portfolio. ª University School of Breakthrough Award from the Department Medicine in Cleveland, of Defense (DoD). BWH DOS 11 OH, where she also Dr. Mittendorf is also the principal investigator on a multi-center trial supported by the National Cancer Institute (NCI) evaluating the impact of vaccination in patients with ductal carcinoma in situ, a trial evaluating the impact of preoperative radiation therapy on the immune response in breast tumors, as well as two investigator

New Program Offers Personalized Risk Assessment, Screening, and Prevention Strategies for Patients at Increased Risk cancerof Breast 12 BWH DOS

specialists from Dana-Farber/Brigham and Women’s Cancer Center, Dana-Farber Cancer Institute, and Brigham and Women’s Hospital recently introduced the Breast Cancer Personalized Risk Assessment, Education and Prevention (B-PREP) Program for patients at increased risk for breast cancer and for patients who want to better understand their risk. The B-PREP Program is supported by a Scholars Grant from Susan G. Komen for the Cure®. “ By gaining a better “Our Program is comprised of a multidisciplinary team of breast specialists, understanding of including breast surgeons, medical oncologists, breast imagers, physician their individual breast assistants and nurse practitioners as well as a social worker and patient cancer risk, patients navigator, who collaborate to deliver expert individualized evaluation and will be able to make care,” says Tari A. King, MD, director of the B-PREP Program and chief of more informed Breast Surgery at Dana-Farber/Brigham and Women’s Cancer Center. choices about their options and take Key services in B-PREP include: preventative action with the risk.” Comprehensive Risk Assessment The B-PREP team’s risk assessment evaluates: TARI A. KING, MD • Personal and family history; • Prior findings of atypical hyperplasia (ADH/ALH) or lobular studies include carcinoma in situ (LCIS) or other atypical lesions on breast biopsy; • Breast density; The use of • Lifestyle factors including diet and exercise; 4-hydroxytamoxifen • Hormone use and other exposures contributing to breast cancer risk. topical gel in women with mammographically dense Personalized Risk-Tailored Care and Education breasts Depending on a patient’s level of risk, the B-PREP team offers expanded testing and recommendations, such as: Evaluation of the impact • Enhanced breast imaging, with whole breast ultrasound or magnetic of medical weight loss reduction programs in resonance imaging (MRI), and more frequent clinical breast exams; women at high risk for • Guidelines for lifestyle changes including diet and exercise as well breast cancer as direct referrals to colleagues in the Brigham and Women’s Weight Evaluation of the impact of Management Program; physical activity on markers • Expedited access for genetic counseling and testing through the of breast proliferation as a Cancer Genetics and Prevention Program at Dana-Farber/Brigham surrogate for risk reduction and Women’s Cancer Center; • Options for risk reduction with proven medications as well as access Evaluation of novel agents to clinical trials evaluating novel medications to prevent breast cancer in patients with BRCA development and opportunities to discuss surgical risk reduction germline mutations with prophylactic surgery. Innovative Research With colleagues at Dana-Farber Cancer Institute, the B-PREP team is engaged in a wide range of research studies, including lifestyle interventions and clinical trials of innovative therapies to prevent breast cancer. The B-PREP team is also taking a patient-centered approach to understanding risk by engaging patients to report their own data and experiences over time in the B-PREP program. BWH DOS 13

Weeks after an experimental amputation, Jim Ewing returned to climbing using a standard prosthesis. tomorrow’s todaymedicine 14 BWH DOS

1i9n82 redesign amputation surgery and ankle developed by Herr’s team at 17 years old, Hugh Herr was a develop a prosthesis that could be in collaboration with Carty. The fearless and well-known rock climber controlled by the brain. After several prosthetic limb was designed to when a blizzard trapped him for years of significant pre-clinical connect to Ewing’s muscles so he four days on Mount Washington research at MIT and the New England could control its movements with his in New Hampshire. Hypothermic Organ Bank, the team was ready to brain and feel sensations similar to a and hours from death, he was pilot a new amputation procedure. natural limb. rescued and helicoptered to a nearby If successful, the surgery would hospital where doctors tried to save preserve essential nerve endings Ewing says, “Within minutes his severely frostbitten legs—but in the amputated limb that could of being connected to the robotic ultimately, needed to amputate both improve the amputee’s mobility, prosthesis, I felt like it was part of my legs below the knee. reduce pain, and open the door to body, what Dr. Herr and Dr. Carty testing a new robotic prosthesis. call neurological embodiment. The Eager to return to climbing, Herr sensation of a robotic foot responding tried the prosthetic limbs available at Herr had the perfect patient in to what I am thinking and doing is the time, but was unimpressed. He mind: his longtime friend Jim Ewing, incredible.” focused his attention, and eventually who suffered devastating injuries in his career, on engineering and testing a rock climbing accident. Ewing had While more testing is needed, Carty better-performing prosthetic devices, spent two years seeking medical help and Herr expect a version of the with the goal of developing models to ease the agony of his shattered left that would behave like natural limbs. ankle—with little success. Matthew J. Carty, MD, of BWH (left), confers with Hugh Herr, PhD (center), and Tyler Clites of MIT, as While Herr explored the “I felt like I was trapped in a broken, Jim Ewing (foreground) tests their newly developed possibilities of prosthetic devices disabled body,” Ewing says. “I was in prosthetic device. as director of the Biomechatronics such constant pain I was willing to do Group at the Massachusetts Institute almost anything to make it stop.” prosthesis will be publicly available of Technology (MIT) Media Lab, within a few years. They are already another expert, plastic surgeon Ewing met with Carty for an conducting early-phase research for Matthew J. Carty, MD, was exploring assessment and decided to take a similar amputation procedure and possibilities for limb transplants a chance with the experimental robotic parosthetic for arms. at Brigham and Women’s Hospital amputation procedure, which was (BWH). Carty envisioned a leg funded through The Gillian Reny Carty explains, “We’re beginning transplant surgery that maintains Stepping Strong Center for Trauma to say with more confidence that essential nerve connections between Innovation at BWH. Within six weeks both the procedure and prosthesis the new leg and the brain. He of surgery, Ewing was walking could work for a large population. wondered how a transplanted leg with a standard prosthesis and rock It’s an incredible feeling knowing would perform compared with the climbing again. our work could help redefine the best prosthetic devices. care of amputees and improve “It takes a special kind of person to quality of life for the nearly 1 million “During a standard amputation commit to an experimental medical people worldwide who have limb procedure, the nerve signals that procedure,” Carty says. “We had amputations each year.” ª coordinate between the brain and done a lot of research, but we didn’t limb are cut off, making it nearly know with certainty this was going to impossible for an amputee using a work. In gratitude to Jim’s courageous prosthesis to walk on uneven ground decision to be the first, we named this or balance on one leg,” explains Carty, procedure the Ewing amputation.” director of the Lower Extremity Transplant Program at BWH and Ewing has no regrets. “It’s tough Brigham and Women’s Faulkner being an amputee, but it’s led me Hospital. down this new path and given me a chance to experience groundbreaking When Herr and Carty learned technology,” he says. of each other’s efforts, their brainstorming led to a new idea: to Following the surgery, Ewing began testing a prototype foot/ BWH DOS 15

Education CURRENT RESIDENTS Venkat Ramakrishnan, MD University of Louisville School of Medicine The Department of General Surgery Surgery combines top- PGY 2 notch clinical care with Program Director: world-class research and Douglas S. Smink, MD, MPH Rachel Atkinson, MD cutting-edge education to Geisel School of Medicine at Dartmouth provide comprehensive PGY 1 surgical training programs. CATEGORICAL Sourav Bose, MD Teaching tomorrows Perelman School of Medicine at the leaders today… James Etheridge, MD University of Pennsylvania Eastern Virginia Medical School 111 Frances Hu, MD interns and residents Katherine He, MD Emory University School of Medicine University of Michigan Medical School 41 Lenka Ilcisin, MD fellows Patrick Heindel, MD Harvard Medical School Keck School of Medicine of the University 5 of Southern California James Luo, MD University of Chicago Pritzker School of ACGME-accredited Paige Newell, MD Medicine surgical Lewis Katz School of Medicine at Temple University Pooja Neiman, MD fellowships David Geffen School of Medicine at UCLA Mehida Rojas-Alexandre, MD 4 Yale School of Medicine Paul Salem, MD Mayo Clinic School of Medicine ACGME-accredited Eva Rouanet Hendrix, MD surgical residency University of Massachusetts Medical School Elizabeth Yates, MD University of Michigan Medical School programs Matthew Vivero, MD Columbia University Vagelos College Bixiao Zhao, MD, PhD 16 BWH DOS of Physicians and Surgeons Yale School of Medicine Vanessa Welten, MD PGY 3 Northwestern University Feinberg School of Medicine Samuel Enumah, MD Johns Hopkins University School of Medicine Christine Wu, MD University of Michigan Medical School Anthony Haddad, MD American University of Beirut Medical School PRELIMINARY Joshua Jolissaint, MD Toby Emanuel, MD University of Virginia School of Medicine The Warren Alpert Medical School of Brown University Abby Larson, MD Johns Hopkins University School of Medicine Jessica Feliz, MD University of Virginia School of Medicine George Li, MD Duke University School of Medicine Ines Lains, MD Universidade de Coimbra, Portugal Alessandra Moore, MD University of Massachusetts Medical School Prashin Unadkat, MD K. J. Somaiya Medical College, India Linda Pak, MD University of Michigan Medical School PRELIMINARY IR Lily Saadat, MD Sukjin Koh, MD Northwestern University Feinberg School Oregon Health & Science University of Medicine Philip Panic, MD Nidhi Udyavar, MD Tufts University School of Medicine George Washington University School of Medicine and Health Sciences PRELIMINARY UROLOGY PGY 4 Tracy Han, MD Duke University School of Medicine Alexandra Columbus, MD Sidney Kimmel Medical College at Thomas Kevin Melnick, MD Jefferson University Emory University School of Medicine

Gillian Fell, MD Joseph Mets, MD Sophie Hofferberth, MD, PGY 2 2 Harvard Medical School Harvard Medical School University of Melbourne Medical School 0 1 David Harris, MD Peter Najjar, MD, MBA Jamie Knell, MD, PGY 3 8 University of Virginia School of Medicine University of Chicago Pritzker School University of California San Diego School of Medicine of Medicine A Elizabeth Lilley, MD N Rutgers Robert Wood Johnson Medical Anupamaa Seshadri, MD Pamela Lu, MD, PGY 3 N School University of Maryland School of Medicine University of Massachusetts Medical School U A Rebecca Scully, MD Bethany Strong, MD Heather Lyu, MD, PGY 3 L Geisel School of Medicine at Dartmouth Harvard Medical School Johns Hopkins University School of Medicine R James Senturk, MD, PhD Lindsey Wolf, MD Arin Madenci, MD, PGY 3 E Icahn School of Medicine at Mount Sinai University of California San Francisco School University of Michigan Medical School P of Medicine O Kristin Sonderman, MD, MPH David Mahvi, MD, PGY 2 R University of Wisconsin School of Medicine RESEARCH University of Wisconsin School of Medicine T and Public Health and Public Health Karan Chhabra, MD, PGY 2 Russell Witt, MD University of Michigan Medical School Danny Mou, MD, PGY 3 University of California Davis School Emory University School of Medicine of Medicine Bryan Dieffenbach, MD, PGY 3 University of California San Diego School Laura Piechura, MD, PGY 3 PGY 5 of Medicine Stanford University School of Medicine Marko Boskovski, MD Jonathan Dunlap, MD, PGY 3 Jason Pradarelli, MD, PGY 2 Yale School of Medicine Stanford University School of Medicine University of Michigan Medical School Julius Ejiofor, MD Adam Fields, MD, PGY 2 Rowza Rumma, MD, PGY 2 University of Texas Southwestern Medical Icahn School of Medicine at Mount Sinai Stanford University School of Medicine School Sameer Hirji, MD, PGY 2 From L-R, Jason Pradarelli, MD, PGY 2, Jonathan Melissa Mallory, MD Johns Hopkins University School of Medicine Dunlap, MD, PGY 3, Sameer Hirji, MD, PGY 2, Douglas University of Virginia School of Medicine S. Smink, MD, MPH (General Surgery Residency Program Director), and Heather Lyu, MD, PGY 3, participate in a surgical simulation training. BWH DOS 17

Morgan Harloff, MD, PGY 3 Jenny Chen, MD Kaohsiung Medical University, Taiwan Harvard Medical School From L-R: Mario A. Aycart, MD; Ann DeBord Smith, RESEARCH Shekhar Gadkaree, MD MD, MPH; Gaurav Sharma, MD; John W. Scott, MD, Johns Hopkins University School of Medicine MPH; Monica Valero Camacho, MD; Thomas C. Tsai, Farhang Yazdchi, MD, PGY 3 MD, MPH; and Gerard M. Doherty, MD Shahid Beheshti University of Medical Vivek Kanumuri, MD Sciences, Iran Rutgers Robert Wood Johnson Medical School Yifan Zheng, MD, PGY 3 Boston University School of Medicine Ashley Miller, MD University of Michigan Medical School 2018 GRADUATES PGY 4 Ashley E. Aaron, MD Otolaryngology Alessandra Colaianni, MD Surgical Critical Care Fellowship, Brigham Johns Hopkins University School of Medicine and Women’s Hospital, Boston, MA Program Director: Harvard Otolaryngology Residency Allen Feng, MD Mario A. Aycart, MD Program: Stacey T. Gray, MD Johns Hopkins University School of Medicine Harvard Plastic Surgery Residency Program, Assistant Program Director: Kevin S. Boston, MA Emerick, MD Natalie Justicz, MD BWH Site Director: Alice Z. Maxfield, Emory University School of Medicine Monica Valero Camacho, MD MD Breast Surgery Fellowship, Memorial Sloan Anuraag Parikh, MD Kettering Cancer Center, New York, NY PGY 1 Columbia University Vagelos College of Physicians and Surgeons John W. Scott, MD, MPH Ciersten Burks, MD Trauma and Critical Care Fellowship, Indiana University School of Medicine Alisa Yamasaki, MD Harborview Medical Center, University of Harvard Medical School Washington, Seattle, WA Lauren Miller, MD Perelman School of Medicine at the CHIEF RESIDENTS Gaurav Sharma, MD University of Pennsylvania Homan’s Vascular and Endovascular Surgery Ashton Lehmann, MD Fellowship, Brigham and Women’s Hospital, Christopher McHugh, MD, PhD Harvard Medical School Boston, MA Wayne State University School of Medicine Brian Lin, MD Ann DeBord Smith, MD, MPH Tara Mokhtari, MD Johns Hopkins University School of Medicine Minimally Invasive Surgery Fellowship, Stanford University School of Medicine University of Massachusetts Medical School, Katie Phillips, MD Worcester, MA Alan Workman, MD The Ohio State University College of Medicine Perelman School of Medicine at the Thomas C. Tsai, MD, MPH University of Pennsylvania Yin Ren MD, PhD Minimally Invasive Bariatric and Advanced Harvard Medical School GI Surgery Fellowship, Massachusetts PGY 2 General Hospital, Boston, MA Rosh Sethi, MD, MPH Harvard Medical School Cardiothoracic Surgery Eric Barbarite, MD 2018 GRADUATES University of Miami Miller School of Medicine Program Director: Jennifer C. Fuller, MD Michael T. Jaklitsch, MD Adeep Derakhshan, MD Facial Plastic and Reconstructive Surgery Cleveland Clinic Lerner College of Medicine Fellowship, University of Minnesota Medical INTEGRATED (I-6) PROGRAM of Case Western Reserve University School, Minneapolis, MN Sue Wang, MD, PGY 1 Krupa Patel, MD Deepa J. Galaiya, MD University of California San Francisco School Weill Cornell Graduate School of Medical Neurotology Fellowship, Johns Hopkins of Medicine Sciences University School of Medicine, Baltimore, MD Hoda Javadikasgari, MD, PGY 1 Tiffany Wang, MD Elliott D. Kozin, MD Tehran University of Medical Sciences, Iran Keck School of Medicine of the University Neurotology Fellowship, Massachusetts Eye of Southern California and Ear, Boston, MA Kathleen Weiss, MD, PGY 2 University of Miami Miller School of Medicine Phoebe Kuo Yu, MD Sidharth V. Puram, MD, PhD Yale School of Medicine Head and Neck Oncologic Surgery Ariana Bratt, MD, PGY 3 Fellowship, The Ohio State University College University of California San Francisco School PGY 3 of Medicine, Columbus, OH of Medicine Nicholas Abt, MD Johns Hopkins University School of Medicine 18 BWH DOS

Plastic Surgery CHIEF RESIDENTS Urology Program Director: Brian Freniere, MD Program Director: Harvard Plastic Surgery Residency University of Massachusetts Medical School George Haleblian, MD Program: Michael Yaremchuk, MD Associate Program Director/BWH Site Johanna Riesel, MD PGY 2 Director: Stephanie Caterson, MD, MSc Vanderbilt University School of Medicine Erica Ditkoff, MD INTEGRATED PROGRAM Danny Roh, MD, PhD Columbia University Vagelos College University of Pittsburgh School of Medicine of Physicians and Surgeons PGY 1 Gricelda Gomez, MD Harvard Medical School Olivia Abbate, MD INDEPENDENT PROGRAM Stephen Reese, MD Georgetown University School of Medicine Boston University School of Medicine SENIOR RESIDENTS Sarah Karinja, MD PGY 3 Columbia University Vagelos College of KC Collins, MD, MBA Physicians and Surgeons Tufts University School of Medicine Alexandra J Berger, MD The Warren Alpert Medical School of Brown Eric Wenzinger, MD Ashleigh Francis, MD University Medical University of South Carolina McGovern Medical School at the University Manuel Ozambela, MD of Texas – Houston Harvard Medical School PGY 2 Julie Szymaniak, MD Mark Greyson, MD Rutgers Robert Wood Johnson Medical Jason Clain, MD University of Virginia School of Medicine School Tufts University School of Medicine CHIEF RESIDENTS PGY 4 Brittany Vieira, MD Northwestern University Feinberg School of Avery Capone, MD Hyo Sang Chiang, MD Medicine Georgetown University School of Medicine Harvard Medical School Jeffrey Howard, MD Frankie Wong, MD Ryan Cauley, MD Baylor College of Medicine David Geffen School of Medicine at UCLA Weill Cornell Graduate School of Medical Valary Raup, MD Sciences Washington University of School of Medicine PGY 3 Shawn Diamond, MD PGY 5 Timothy Irwin, MD Weill Cornell Graduate School of Medical Pennsylvania State University College of Sciences Tyler McClintock, MD Medicine New York University School of Medicine 2018 GRADUATES Jacqueline Speed, MD Dylan Perry, MD Columbia University Vagelos College of University of Massachusetts Medical School Ramon Arscott, MD, PhD Physicians and Surgeons Private Practice, Jamaica & Bermuda Arman Serebrakian, MD, MS 2018 GRADUATES Lewis Katz School of Medicine at Erez Dayan, MD Temple University Aesthetic Surgery Fellowship, Dallas Plastic David Friedlander, MD, MPH Surgery Institute, Dallas, TX NIH Research Fellowship, Brigham and PGY 4 Women’s Hospital, Boston, MA Christopher Hughes, MD, MPH Endourology/Laparoscopic Fellowship, UC Lisa Gfrerer, MD, PhD Pediatric Craniofacial Fellowship, Boston San Diego and Kaiser Permanente, San Medical University of Vienna, Austria Children's Hospital, Boston, MA Diego, CA Philip Cheng, MD Brent Pickrell, MD Edward Kobraei, MD Male Reconstruction and Male Infertility Baylor College of Medicine Hand Surgery Fellowship, University Fellowship, University of Utah, Salt Lake City, of Southern California, San Diego, CA UT Jacob Rinkinen, MD Michael Zavaski, MD University of Michigan Medical School Nikki Phillips, MD Private Practice, Springfield, MA Aesthetic Surgery Fellowship, Gold Coast, SENIOR RESIDENTS Australia BWH DOS 19 Joani Christensen, MD Brady Sieber, MD Johns Hopkins University School of Medicine Microsurgery Fellowship, Beth Israel Deaconess Hospital, Boston, MA David Mattos, MD, MBA Harvard Medical School Erin Taylor, MD Columbia University Vagelos College of Physicians and Surgeons

CURRENT FELLOWS Acute Care Caroline Jones McGuin, MD Cardiothoracic Surgery Fellowship University of Texas Southwestern Medical Surgery Transplant School Fellowship Program Director: Program Director: Reza Askari, MD Steve K. Singh, MD Sean Hickey, MD Cardiothoracic Mohamed Keshk, MD University of California San Diego School Surgery Fellowship Cairo University, Kasr El-Aini School of Medicine of Medicine, Egypt Program Director: 2018 GRADUATES Michael T. Jaklitsch, MD 2018 GRADUATE Anthony Coppolino, MD Matthew Giangola, MD Kareem Bedeir, MD, PGY 7 Attending Surgeon, Brigham and Women’s Attending Surgeon, Northwell Health, NY Alexandria University School of Medicine, Hospital, Boston, MA Jeffrey Skubic, DO Egypt Attending Surgeon, University of Texas Rio Colorectal Surgery Grande Valley School of Medicine, Hassan Khalil, MD, PGY 6 Fellowship Edinburg, TX McGovern Medical School at the University of Texas – Houston Program Director: Adult Cardiac Ronald Bleday, MD Surgery Fellowship Andrew Papoy, MD, PGY 6 University of Kentucky College of Medicine Anne Fabrizio, MD Program Director: Rutgers Robert Wood Johnson Medical Tsuyoshi Kaneko, MD Sunu Philip, MD, PGY 6 School University of Cape Town Medical School, Yuji Kawano, MD South Africa 2018 GRADUATE Osaka University, Japan Isidore Dinga Madou, MD, PGY 7 Michael Morton, MD Advanced Laparoscopic Jacobs School of Medicine and Biomedical Attending Surgeon, Portsmouth Regional Fellowship Sciences at the University of Buffalo Hospital, Portsmouth, NH Program Director: Alexi Matousek, MD, PGY 7 Endocrine Surgery Ali Tavakkoli, MD University of Rochester School of Medicine Fellowship and Dentistry Program Director: Taufiek Konrad Rajab, MBBS, PGY 7 Matthew A. Nehs, MD University of Cambridge, School of Clinical Medicine, England T.K. Pandian, MD Mayo Clinic School of Medicine Paul Toste, MD, PGY 7 University of Cincinnati College of Medicine 2018 GRADUATE Peter Szasz, MD 2018 GRADUATES Lindsay Kuo, MD University of Toronto Medical School, Attending Surgeon, Lewis Katz School Canada Matthew Rochefort, MD of Medicine at Temple University, Attending Surgeon, Brigham and Women’s Philadelphia, PA 2018 GRADUATE Hospital, Boston, MA Reuben Shin, MD Ashraf Sabe, MD Attending Surgeon, Lahey Hospital & Medical Aortic Fellowship, Duke University School Center, Burlington, MA of Medicine, Durham, NC Rona Spector, MD Cardiothoracic Surgery Transplant Fellowship Breast Surgery Fellowship Program Director: Mehra Golshan, MD Stephanie Wong, MD McGill University Medical School, Canada 20 BWH DOS

General Thoracic Surgical Critical Daniel Pucheril, MD 2 Surgery Fellowship Care Fellowship Sidney Kimmel Medical College at Thomas 0 Jefferson University 1 Program Director: Program Director: Dimitar Zlatev, MD 8 Michael T. Jaklitsch, MD Reza Askari, MD Stanford University School of Medicine A Carolyn Moore, MD Ashley Aaron, MD 2018 GRADUATES N The Medical College of Georgia University of Minnesota Medical School N Mehreen Kisat, MD Matthew Mossanen, MD U Jillian Sinopoli, DO Aga Khan University Medical College, Pakistan Attending Surgeon, Brigham and Women’s A Rocky Vista University College of Kathryn Van Orden, MD Hospital, Boston, MA L Osteopathic Medicine Rutgers Robert Wood Johnson Medical School Matthew Ingham, MD Attending Surgeon, Brigham and Women’s R Desiree Steimer, MD 2018 GRADUATES Hospital, Boston, MA E University of Kentucky College of Medicine P Ian Driscoll, MD Vascular Surgery Fellowship O Danielle Thesier, MD Attending Surgeon, University of Florida Health, R Jacobs School of Medicine and Biomedical Gainesville, FL Program Director: T Sciences at the University of Buffalo Tovy Kamine, MD Matthew Menard, MD Melanie Sion, MD 2018 GRADUATES Attending Surgeon, Yale School of Medicine, Gaurav Sharma, MD New Haven, CT Keck School of Medicine of the University Hassan Khalil, MD Sharven Taghavi, MD, MPH of Southern California Cardiothoracic Surgery Residency, Brigham Attending Surgeon, Tulane University School Jillian Walsh, MD and Women’s Hospital, Boston, MA of Medicine, New Orleans, LA Schulich School of Medicine & Dentistry at Western University, Canada Maria Rodriguez Perez, MD Surgical Oncology Fellowship Christine Lotto, MD Attending Surgeon, Salamanca University Sidney Kimmel Medical College at Thomas Hospital, Spain Program Director: Jefferson University Chandrajit P. Raut, MD, MSc Lowell Su, MD 2018 GRADUATE Cardiothoracic Surgery Residency, Tufts George Molina, MD University School of Medicine, Boston, MA Harvard Medical School Stuart Blackwood, MD Akhil Chawla, MD Private Practice, Syracuse, NY Minimally Invasive Thoracic University of Cincinnati College of Medicine Surgery Fellowship 2018 GRADUATE Program Director: Jon O. Wee, MD Mark Fairweather, MD Attending Surgeon, Brigham and Women’s Zeynep Bilgi, MD Hospital, Boston, MA Marmara University School of Medicine, Turkey Urological Oncology Fellowship Apostolos Kandalis, MD University of Athens Medical School, Greece Program Director: Steven L. Chang, MD, MS 2018 GRADUATES Melissa Huynh, MD Flavio Brito Filho, MD Schulich School of Medicine & Dentistry Attending Surgeon, Hospital de Base do Distrito at Western University, Canada Federal, Brazil Alice Yu, MD Rafael Garza Castillon, Jr., MD McGill University Medical School, Canada General Thoracic Surgery Fellow, Brigham and Women’s Hospital, Boston, MA BWH DOS 21

VISITING PROFESSORS Nancy L. Cho, MD and Erika L. Rangel, MD Appointed BWH Surgery Associate Clerkship David J. Sugarbaker, MD Lectureship Directors in Thoracic Surgery Thomas A. D’Amico, MD Nancy L. Cho, MD and Erika L. Rangel, MD, have been appointed associate Duke University School of Medicine clerkship directors in the Department of Surgery. In this important role, they will help to oversee the Core Surgery rotation during the HMS Primary Gerald and Elaine Schuster Clinical Experience in collaboration with clerkship director Reza Askari, MD. Distinguished Lecturer in Thoracic Surgery NANCY L. CHO, MD • Assistant Professor of Surgery Mark S. Allen, MD Mayo Clinic School of Medicine Dr. Cho is an associate NY and completed both her General surgeon in the Division Surgery Residency and Endocrine Surgery Joseph E. Murray Visiting Professor of General and Fellowship at BWH. in Transplant Surgery Gastrointestinal Surgery, Peter J. Friend, MD, FRCS Section of Endocrine Dr. Cho is board certified in General University of Oxford Surgery at Brigham and Surgery. Her clinical interests include Women’s Hospital (BWH) and assistant endocrine diseases of the thyroid/ Gordon C. Vineyard Lecturer professor of surgery at Harvard Medical parathyroid glands and melanoma. Her in Surgery School. She received her medical degree primary research focus involves studying Robert H. Bartlett, MD from Columbia University, College of tumor-stroma biology with the goal of University of Michigan Medical School Physicians and Surgeons in New York, developing more effective, patient-specific treatment strategies. ª Hechtman Trauma Lecturer in Surgery ERIKA L. RANGEL, MD, MS, FACS • Assistant Professor of Surgery Eileen M. Bulger, MD, FACS University of Washington School of Medicine Dr. Rangel is an BWH. associate surgeon in Dr. Rangel is board certified in both John A. Mannick Visiting Professor the Division of Trauma, General Surgery and Surgical Critical in Vascular Surgery Burn, Surgical & Critical Care. Her clinical interests include: Andres Schanzer, MD Care at Brigham and acute care surgery, biliary tract disease, University of Massachusetts Medical School Women’s Hospital minimally invasive hernia surgery, (BWH) and assistant professor of surgery abdominal wall reconstruction and Lawrence and Judith Schlager Family at Harvard Medical School. She received diverticular disease. Her academic Lecturer in Surgical Oncology her medical degree from the University research focuses on surgical education, Andrew M. Lowy, MD, FACS of California San Francisco (USCF) School parenting and work-life integration during University of California San Diego School of Medicine in San Francisco, CA and residency and improving outcomes of Medicine completed both her General Surgery for geriatric patients after emergency Residency and Critical Care Fellowship at surgery. ª Lawrence H. Cohn, MD Visiting Professor in Cardiac Surgery Gebrine El Khoury, MD Cliniques Universitaires Saint-Luc Nina S. Braunwald Visiting Lecturer in Surgery Joanna Chikwe, MD Stony Brook School of Medicine Gelman-Zinner Visiting Professor in Surgery, Anesthesiology, Perioperative and Pain Medicine Taylor S. Riall, MD, PhD, FACS University of Arizona College of Medicine Pro Tempore Visiting Professor Francis D. Moore, MD Lecturer in Surgery Mary Hawn, MD, MPH, FACS Stanford University School of Medicine 22 BWH DOS

Research 202 379 2 active contracts active protocols 0 435 1 total research funds 8 A N N U A L R E P O R T 47 research fellows $33,005,959 total research spending BWH DOS 23

SELECTED GRANTS T Cells and Rejection in Vascularized An Open Label Window of Composite Allotransplants Opportunity Phase II Study of the FAK Aging-associated dysregulation of PI • Bohdan Pomahac, MD Inhibitor VS-6063 in Participants with the hypoxia pathway limits skeletal Co-PI • Rachael Clark, MD (BWH Surgical Resectable Malignant Pleural muscle regeneration Dermatology) Mesothelioma PI • Indranil Sinha, MD Sponsor • U.S. Army Medical Research PI • Raphael Bueno, MD Sponsor • NIH-NIA Acquisition Activity Co-PI(s) • Carol B. Benson, MD (Radiology), Grant Number • 1K76AG05996-01 Grant Number • W81XWH-18-1-0784 Marcelo C. DaSilva, MD, Mary C. Frates, MD Grant Amount • $1,209,880 Grant Amount • $1,236,771 (Radiology), Ritu R. Gill, MD, MPH (Radiology), David M. Jackman, MD (Oncology), David J. Evaluation of a Cultural Dexterity From L-R, Brigham Surgery Resident David Harris, Kwiatkowski, MD,PhD (Oncology), Abraham Training Program for Surgeons MD, PGY 4, discusses a research project with Eric Lebenthal, MD, Eric J. Schmidlin, MD • The PACTS Trial G. Sheu, MD, PhD, and Ali Tavakkoli, MD, in the (Radiology), Scott J. Swanson, MD PI • Adil H. Haider, MD, MPH Laboratory for Surgical and Metabolic Research. Sponsor • Verastem, Inc. BWH Co-Investigators • Douglas S. Smink, MD,MPM SELECTED A Phase II, Open-Label, Multicenter, External Co-Investigators • Alexander CLINICAL TRIALS Single-Arm Study to Investigate the Green, MD (MGH), John Mullen, MD efficacy and safety of Atezolizumab (MGH), Emil Petrusa, PhD (MGH), L.D. Britt, Phase II Randomized, Double-Blind, as Neoadjuvant and Adjuvant MD, MPH (EVMS), David Harrington, MD Placebo-Controlled, Parallel-Group Therpay in Patients with stage IB, II, (LifeSpan), Tara Kent, MD (BIDMC), Anne Study to Evaluate the Safety and IIIA or Selected IIIB Resectable and Larkin, MD (Umass), Pamela Lipsett, MD Efficacy of Reltecimod as compared untreated non-small cell lung cancer (JHU), Lori Wilson, MD (Howard) to placebo in addition to standard PI • Ciaran McNamee, MD Sponsor • NIH-NIMHD of care in patients with sepsis- Co-PI(s) • Gainor (Site-PI @ MGH), Johnson, Grant Number • 1R01MD011685-01 associated acute kidney injury (Site-PI @ DFCI), all Division of Thoracic Grant Amount • $3,432,688 (SA-AKI) Surgery at BWH and MGH, all Thoracic PI • Reza Askari, MD Oncology at DFCI and MGH Therapy of acute radiation Sponsor • Atox Bio, Ltd. Sponsor • Genentech, Inc. syndrome and its complications by mensenchymal stromal cells Uterine Transplantation for Image guided VATS resection vs. VATS conditioned with absoluteuterine factor infertility resection of lung lesions Toll-like receptor 9 agonists (AUFI) PI • Raphael Bueno, MD PI • James A. Lederer, PhD PI • Stefan Tullius, MD, PhD Co-PI(s) • Schmidlin (Radiology), all Division Co-PI(s) • Mark A. Perrella, MD Co-PI(s) • Marc R. Laufer, MD, of Thoracic Surgery attendings Sponsor • NIH-NIAID Antonio Rosario Gargiulo, MD Sponsor • Siemens, Inc. Grant Number • 1U01AI38318-01 Sponsor • N/A Grant Amount • $2,911,300 Focal MR-Guided Focused Ultrasound Bronchial NIR Image-guided Treatment of Localized Intermediate Developing Disparities-Sensitive Resection, Mapping and Targeted Risk Prostate Lesions Surgical Quality Metrics Across the Lymphadenectomy for Lung Lesions PI • Clare Mary C. Tempany, MD (Radiology) Continuum of Care PI • Yolonda Colson, MD, PhD Co-PIs • Adam Kibel, MD; PI • Adil H. Haider, MD, MPH Co-PI(s) • Raphael Bueno, MD, Christopher Quoc-Dien Trinh, MD Co-PI(s) • Awarded to L.D. Britt, MD, MPH T. Ducko, MD, Ritu R. Gill, MD, MPH Sponsor • Insightec (ACS) (Radiology), Michael T. Jaklitsch, MD, Ciaran Sponsor • NIH-NIMHD via The American McNamee, MD, Robert F. Padera, Jr., MD, A Phase II Clinical Trial to Study the College of Surgeons PhD, Eric J. Schmidlin, MD (Radiology), Scott Efficacy and Safety of Pembrolizumab Grant Number • 1R01MD011695-01 J. Swanson, MD, Hisashi Tsukada, MD, PhD, (MK-3475) in Subjects with High Risk Grant Amount • $1,136,944 Jon O. Wee, MD, Abby White, DO, Daniel C. Non-muscle Invasive Bladder Cancer Wiener, MD (NMIBC) Unresponsive to Bacillus A Novel Approach to Upper Sponsor • Society of University Surgeons Calmette-Guerin (BCG) Therapy Extremity Amputation to Augment PI • Mark A. Preston, MD, MPH Volitional Motor Control and Restore Sponsor • Merck Proprioception PI • Matthew J. Carty, MD Development and Validation of a BWH Co-Investigators • Simon Talbot, MD Patient Reported outcome Measure (Plastic Surgery), Stuart Lipsitz, ScD (General for Underactive Bladder (UAB) Medicine), Anthony Amato, MD (Neurology), PI • Michael O'Leary, MD, MPH George Dyer, MD (Orthopedics), M. Stephen Sponsor • NE Research Institute Ledbetter, MD (Radiology) External Co-Investigators • Hugh Herr A Randomized, Double-blind, Single- (MIT), Jason Souza, MD (USU), Jonathan Center Trial of Alvimopan (Entereg) Forsberg, MD (USU), Scott Tintle, MD (USU), versus Placebo in Patients undergoing Paul Pasquina, MD (USU) Radical Cystectomy and Urinary Sponsor • Department of the Army - Diversion on an Enhanced Recovery USAMR A A after Surgery (ERAS) Protocol Contract Number • W81XWH-18-2-0058 PI • Mark A. Preston, MD, MPH Contract Amount • $3,000,000 Sponsor • PI initiated (funding from Merck) 24 BWH DOS

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PATIENT-REPORTED OUTCOMES, VALUE AND EXPERIENCE (PROVE) CENTER proveCenter Aims to Transform Care Using Patient-Reported Outcomes Pictured L-R, PROVE Center director Andrea Pusic, MD, and co-director Christopher Gibbons, PhD, bring more than 25 years of experience in PROM research and development. In March 2018, Brigham and intervention is to make a patient in ways that help drive routine care Women’s Hospital (BWH) took our feel or function better. Collecting and decision-making to improve longstanding commitment to patient- patient-reported outcomes engages patient outcomes. With access to centered care to a new level with patients in their own care, provides robust and easily usable tools to the launch of the Patient-Reported data about outcomes that matter to collect PROMs, health care teams Outcomes, Value & Experience patients, offers new insights into will be able to use that information (PROVE) Center. Over the last five patient behavior, and helps tailor care to improve an individual patient’s years, BWH has been a leader in the to individual patients and specific care, as well as to improve the care of collection of patient-reported outcome patient groups. specific patient populations. measures, or PROMs. Many health care systems are “Analysis of aggregate patient- “PROMs are outcomes that only grappling with how to efficiently reported outcome data will enable patients can tell us about,” says collect and integrate PROMs into health care researchers to identify PROVE Center director, Andrea routine care. By establishing the areas to improve care and determine Pusic, MD. “They include things like PROVE Center, BWH has made the value of specific procedures pain, quality of life, body image, a huge investment in collecting or treatments in terms of how physical function, and the experience patient-reported outcomes data on a they improve a patient’s self- of care.” PROMs data are essential large scale and making it possible to reported health or quality of life,” whenever the goal of a health care communicate feedback from PROMs explains PROVE Center co-director, 26 BWH DOS

Christopher Gibbons, PhD. In “Drs. Pusic and Gibbons are based on the patient’s goals for addition to being used to determine internationally recognized leaders the procedure, such as pain relief, the relative value of different in the areas of patient-reported improved joint function, or better treatments, these data can also be outcomes and surgical experience,” body image. Furthermore, patient- used to drive quality improvements says Gerard M. Doherty, surgeon- reported outcomes data can provide and identify and address disparities in-chief of Brigham Health. “This valuable information about patient in health care. is increasingly important in the satisfaction and quality of life that can current health care environment be incorporated into comprehensive PROVE CENTER LEADERSHIP of measuring quality, assessing cost-effectiveness analyses of surgical value and ultimately, influencing procedures (e.g., cost per quality- Collectively, PROVE Center director how health care is funded. The adjusted life-year). Andrea Pusic, MD, and co-director development of the PROVE Center Christopher Gibbons, PhD, bring will create opportunities throughout “We envision the PROVE Center more than 25 years of experience in the Brigham and Boston communities as a hub for innovation and PROM research and development. for both research and clinical patient advancement in the field of patient- care initiatives.” reported outcomes, both inside and Dr. Pusic is an internationally- outside of BWH,” says Dr. Pusic. renowned innovator and leader in AN AGILE INNOVATION LAB With that in mind, the PROVE patient-reported outcomes and patient Center is already partnering with the satisfaction in surgery, as well as By investing in the PROVE International Consortium for Health chief of Plastic and Reconstructive Center, BWH is leading the field Outcomes Measurement (ICHOM) Surgery at Brigham Health and in reimagining care based on and Harvard Business School Joseph E. Murray Professor of Surgery patient-reported outcomes. The (HBS) on a breast cancer PROMs at Harvard Medical School. With PROVE Center aims to make it easy project. ICHOM, whose mission is dual training in epidemiology and for clinicians to find and utilize to standardize the measurement surgery, she leads a team of experts compelling, meaningful information and reporting of patient outcomes, in psychometrics, quality of life, and to help improve the lives of patients. organizes global teams of physician social science methods to develop, leaders, outcomes researchers and validate and use new quantitative “We see ourselves as a small, agile patient advocates to define sets of measures to assess patient outcomes. innovation lab,” says Dr. Pusic. “We’re outcome measures for each medical The patient-reported outcomes developing a scalable model within condition and enable health care instrument she developed for breast the Department of Surgery that can be providers globally to compare, learn, surgery, the BREAST-Q, has been expanded over time to include other and improve. adopted globally for research and disciplines.” The Center’s unique clinical care and serves as a model for focus on both surgery and PROM data NOT YOUR TYPICAL new outcome measures in surgery. collection currently includes projects in breast and plastic surgery, urology, QUESTIONNAIRES Dr. Gibbons is a data scientist ENT, orthopedics, neurosurgery, and international expert in the and bariatric and thyroid surgery, as Today’s PROM technology has development and application of novel well as overlapping disciplines, such computational capabilities that allow techniques for collection, analysis as radiation oncology and medical for more flexible measurement of and feedback of patient-reported oncology for breast cancer care. patient-reported outcomes that was outcomes, including computerized not possible with earlier quality-of-life adaptive testing, predictive analytics, Cutting-edge computational assessments. A few examples include machine learning, and natural technologies and algorithms will be the aforementioned BREAST-Q for language processing. Prior to joining used to provide immediate feedback breast surgery patients, the BODY-Q BWH, Dr. Gibbons was director of of individual patient outcomes, as for bariatric surgery patients, and Health Assessment and Innovation well as deliver insights from analysis the Patient-Reported Outcomes at the Psychometrics Centre at the of aggregate data at regular intervals. Measurement Information System University of Cambridge where he led In the surgical arena, data-driven (PROMIS) that evaluates and monitors projects focused on psychometrics, analytics that can predict future physical, mental, and social health big data and machine learning, patient-reported outcomes, such in adults and children in the general and developed an award-winning as pain or satisfaction, would be population. application that combined predictive enormously beneficial for comparing algorithms with 2.5 billion publicly different surgical options that have “PROMs are more than just surveys available data points to create equivalent survival rates or risks of or questionnaires,” says Dr. Gibbons. interactive visualizations of health complications. The right operation for “They are precisely calibrated tools and social outcomes. the right patient could be determined which minimize biases in assessment and can detect small-but-meaningful BWH DOS 27

changes in patient-reported outcomes adaptive testing, whereby an algorithm to glean meaning from open-text between treatments and over time.” iteratively matches participants with survey responses, providing an the most relevant items for them to additional layer of insight to the “Psychometrics allows us to measure answer based on their preceding quantitative PROM data. Data subjective outcomes and reliably answers. Reducing the number of scientists train these algorithms assess constructs that have long been questions each patient answers and using precoded data and validate the considered ‘soft’,” explains Dr. Gibbons. the time it takes to complete the algorithm’s performance on uncoded “It allows us to measure things that assessment increases the likelihood of data, in a process called “supervised” we couldn’t otherwise quantify, patients completing the assessment. machine learning. It is even possible such as how a treatment affects a to deploy these trained algorithms patient’s quality of life.” Psychometrics Modern PROMs also harness the to operate on data as they are being is the science that underpins the power of machine learning to make collected, allowing real-time feedback testing of reliability, validity, and predictions based on large datasets and insight from open-text survey data. responsiveness of measurement and to glean meaning from open- tools. To be clinically meaningful, a text comments. Consider that more A VISION FOR THE FUTURE measurement tool must address issues than 30,000 patients have taken the that are important to patients and their BREAST-Q. That is an extraordinary BWH is deeply committed to patient- doctors. To be scientifically sound, amount of data to analyze. With centered care and enhancing the it must demonstrate reliable, valid, predictive analytics, thousands of patient voice in health care decisions. and responsive measurement of the data points can be analyzed for more As a hub for PROMs innovation and outcome. accurate prediction of outcomes for advancement, the PROVE Center aims the next patient and for outcomes to engage the BWH infrastructure in The new generation of PROMs are in specific populations. This allows routinely acquiring patient-reported adaptive and attuned to patients. clinicians to provide more tailored outcomes and implementing a culture They were developed in collaboration care and set patient expectations for of clinical care that has patient- with patients and experts, rather than outcomes and possible side effects. reported outcomes embedded within based solely on expert consensus. With natural language processing the care process. ª They are optimized for efficiency and algorithms, computers can be trained brevity by utilizing computerized Welcoming Chris Gibbons as Co-Director of the Patient-Reported Outcomes, Value & Experience (PROVE) Center CHRIS GIBBONS, PhD Chris Gibbons, PhD, techniques have included computerized won multiple international design awards received his doctorate adaptive testing, tailored feedback, including the D&AD Graphite Pencil for from University of predictive analytics, machine learning and “stand-out work, beautifully executed with Liverpool and Walton natural language processing. Dr. Gibbons an original and inspiring idea at its core”. Centre for Neurology was awarded the Young Investigator Award and Neurosurgery. by the International Society for Quality of His research has been generously He conducted postdoctoral research at Life Research for presentation of his work supported by grants from National Institute University of Manchester before developing developing a new method to assess the of Health Research (UK), the Economic and his independent research career at validity of computerized adaptive tests Social Research Fund (UK), Marie Curie University of Cambridge. At the University during live administration. Cancer Charity (UK), the Motor Neurone of Cambridge, Dr. Gibbons was Director Disease Association (UK) and Deutsche of Health Assessment and Innovation at At the Psychometrics Centre, Dr. Gibbons Forschungsgemeinschaft (DE). the Psychometrics Centre ( Judge Business led projects focused on psychometrics, big School) and NIHR Career Development data and machine learning. One industry- Dr. Gibbons is a sought-after Fellow at The Healthcare Improvement sponsored project called ‘Predictive World’ international speaker on patient- Studies (THIS) Institute (School of Clinical led to the development of an application reported data and has been invited to Medicine). which combined predictive algorithms with deliver keynotes, plenaries and technical His research is focused on the 2.5 billion publically available data points to workshops in ten countries. He currently development and application of novel create interactive visualizations of health serves as an editorial board member for techniques for collection, analysis and and social outcomes. The application was Journal of Medical Internet Research was feedback of patient-reported data. These viewed by over a million people in the first selected to be member of an international two weeks of release and subsequently cohort of Future Leaders in Health Data Science by the Farr Institute (UK). ª 28 BWH DOS