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Center for scientific and technical information under the Ministry of Innovative Development of the Republic of Uzbekistan CATALOG OF SCIENTIFIC DEVELOPMENTS AND INNOVATIVE PROJECTS OF SCIENTISTS OF THE REPUBLIC OF UZBEKISTAN Tashkent- 2020



Minister of Innovative Development of the Republic of Uzbekistan Ibrokhim Yu. Abdurakhmonov \"We must improve the quality and coverage of education at all levels, develop the system of continuing education, and ensure the flexibility of the training system based on the needs of the economy. There is an urgent need to strengthen the scientific potential and effectiveness of research and development, and to create effective mechanisms for integrating education, science and entrepreneurship in order to widely implement the results of research, development and technological work. Scientists should be encouraged to implement their developments. To this end, we will create national and regional technology transfer offices. It is planned to create a hub of technoparks, free economic zones, free industrial zones, small industrial zones and research and production clusters for the implementation of advanced technologies.\" Minister of Innovative Development of the Republic of Uzbekistan Ibrokhim Yu. Abdurakhmonov 3

CONTENT ID-1 A system for remote monitoring of photovoltaic power plants (PV) using information 6 technology (Internet). ID-2 Creation of an experimental energy-efficient residential building with solar power and 8 heating system using SRO technologies 10 ID-3 Hybrid solar-fuel power plant for individual use 12 ID-4 Aphrodine is a safe drug with high aphrodisiac activity 14 ID-5 Cyclocardioside - cardioprotective drug 16 ID-6 Ecologically clean biostimulator for agriculture \"Uchkun\" 18 ID-7 Probiotic feed additive \"Baktovit\" for animal husbandry ID-8 Mastering the production of the biological product \"Imbiocon\" for canning and preparation 20 of forage crops ID-9 Technology to obtain a pilot sample of biocatalysis for biotransformation of acrylonitrile in 22 acrylamide - \"Rhodoamid\" ID-10 “Lactopropolis” is a probiotic drug for the prevention and treatment of gastrointestinal 24 ulcers and inflammatory diseases ID-11 “Atheris” is a biologically active supplement for the prevention and treatment of 26 hypercolysterolemia 28 ID-12 Promising variety of cotton UzFA-710 30 ID-13 New variety of cotton UzFA -715 32 ID-14 ”Gen-24”(Ehtiyoj) Soybean Lines 34 ID-15 Promising variety of cotton UzFA-705 36 ID-16 Apicapsalvin is an anti-inflammatory drug ID-17 \"BIOCOR\" (tablet 0.2 g) immunomodulator with antitumor properties 38 ID-18 \"Biomairin\" - a combined long-acting anti-tuberculosis drug 40 42 ID-19 Biosolvent - preparation for effective reclamation of saline soils 44 ID-20 “Gemogubka\" - hemostatic collagen sponge 46 ID-21 Hemostatic drug for local use – Glilagin 48 ID-22 Hemostatic drug for intravenous use – Lagovin 50 ID-23 Gossipol Pharmacopeic 52 ID-24 Composition for pre-planting Cotton - DAG-1 54 ID-25 Pheromone traps against potato moth (Phthorimaea operculella) 56 ID-26 Drug Rutan, which has antiviral action 58 ID-27 Gossitan - anti-flu-action drug 60 ID-28 Getasan, Punitan Anti-HIV Drugs 62 ID-29 Drug Euphorbin, which has anti-HIV activity 64 ID-30 Antidiabetic – Plantagin 66 ID-31 Providine - antihypoxic drug ID-32 Pheromone traps against tomato moth 68 (Tuta absoluta) 4

ID-33 The combined preparation \"Fludigel\" 70 ID-34 ID-35 \"Mixture 0.001%\" - a drug for the treatment of anemia 72 ID-36 Technology and equipment for vacuum freeze drying of products (Vacuum ID-37 Lyophilizer/Vacuum Freeze Dryer) ID-38 74 ID-39 ID-40 Multi-operation machine for machining semi-finished leather goods 76 ID-41 ID-42 Gear-lever differential transmission mechanism(GLDTM) of which the rotational centers of ID-43 the working shafts are symmetrical moving ID-44 ID-45 78 ID-46 ID-47 Pure magnesium sulfate heptahydrate in terms of pharmacopoeia based on local raw ID-48 ID-49 materials ID-50 ID-51 80 ID-52 ID-53 Drug for veterinary medicine 82 ID-54 ID-55 Method of obtaining technical oleic acid 84 Film-ceramic composite based on functional ceramics and polyethylene film 86 Indicator of seismic impact intensity 88 «SeismicRiskAssessment» - software for forecasting of direct damage from a major earthquake 90 Optical power meter for diagnostics of fiber-optic communication lines 92 Photoelectric colorimeter for reagent-free assessment of bilirubin in blood plasma 94 Flame control device for gas burners based on an ultraviolet sensor 96 Antibacterial medical masks modified by silver nanoparticles 98 Baromembrane water desalination system (500 l / h) 100 Radiation sterilization of disposable surgical products made of nonwoven material 102 Radiation crosslinking of polymer heat-shrinkable tubes 104 Technology of producing acrylic acid from Acrylonitrile 106 Technology of superabsorbents obtaining for agriculture and sanitary purposes 108 Protein production technology for fish and poultry farming based on local raw materials 110 Integrated processing technology for silkworm pupae \"Bombyx mori\" 112 Production of nanopolymeric disinfectant solution of \"POLIARDEZ\" 114 5

International Solar Energy Institute ID-1 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / A system for remote monitoring of photovoltaic power plants (PV) using development information technology (Internet). Author`s name / academic Ph.D., senior researcher Matchanov N.A. degree PhD. Kim O.S. Ph.D., senior researcher Zh.Z. Akhadov Brief description The International Institute of Solar Energy is developing and installing a remote monitoring system for photovoltaic power plants (PV) using information technology (Internet). This system allows you to remotely check and store data on the performance of PV, ambient and module temperature. The system will be connected to the Internet; also, based on the developed mobile app, it is possible to control the PV from a mobile phone. Expected results PV control system research Development of a remote monitoring system Mobile application development System installation, internet connection Small-scale production of remote monitoring systems 6

Scope of application RES, resource-saving, energy-saving technologies IPO degree of protection - Form of transfer rights Transfer of technology under a license agreement A laboratory sample has been prepared. Readiness degree of development Technical documentation developed Tested in production conditions. Project implementation Implementation Stages Examination of the control system FES-06.2021. Development of remote monitoring systems-12.2021. Development of mobile applications-06.2022. Small scale production of remote monitoring systems - 12.2022. The period of implementation 2021-2022 years. Need for additional funding, 400.0 million sum for the creation of industrial infrastructure million sum Name of International Solar Energy Institute organization Phone number +99871 235 0344 [email protected] E-mail 7

International Solar Energy Institute ID-2 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Creation of an experimental energy-efficient residential building with development solar power and heating system using SRO technologies Author`s name / academic Ph.D., senior researcher Matchanov N.A. degree Doctor of Technical Sciences, Leading Researcher Avezova N.R. PhD. Kim O.S. Ph.D., senior researcher Zh.Z. Akhadov Brief description Design, creation and commissioning of an experimental energy- efficient residential building with solar power and heat supply system (using SRO technologies) and creation of prerequisites for significant expansion of using scale of autonomous solar power supply systems. Expected results Development of design of an energy efficient residential building with solar power and heat supply system: a choice of technologies and energy efficient building materials. Development of design solution for an energy-efficient residential building with 100% autonomous power supply from solar energy. 8

Scope of application RES, resource-saving, energy-saving technologies IPO degree of protection - Form of transfer rights License agreement Readiness degree of development A sample of an energy efficient house has been built. Developed technical documentation. Tested in production conditions. Project implementation Implementation Stages Development, design, creation and commissioning of an The period of implementation experimental energy-efficient residential building with solar power and heat supply system (using SRO technologies) and the creation of prerequisites for significant expansion of using scale of autonomous solar power supply systems 01.01.2021-31.12.2022. 2021-2022 Need for additional funding, million sum UZS 1,000.0 million sum for the creation of industrial infrastructure Name of International Solar Energy Institute organization Phone number +99871 235 0344 [email protected] E-mail 9

International Institute of Solar Energy ID-3 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Hybrid solar-fuel power plant for individual use development PhD. Kim O.S. Author`s name / academic Ph.D.Matchanov N.A. degree Application of hybrid technologies to solve the problems of efficient Brief description energy supply in rural areas using renewable energy sources. Typical schemes and configurations of hybrid systems, the composition of the Expected results equipment used, the economic aspects of practical application are considered. It has been established that the use of hybrid systems based on photovoltaic modules is a promising solution for decentralized power supply of remote objects and in rural areas, as well as for providing irrigation and drinking water. A remotely controlled solar-fuel hybrid mobile power plant with a capacity of 2 kW is being developed; A 1.5 kW pump is installed for pumping water; A desalination system is installed to obtain drinking water. The expected economic effect from electricity generation is 3650 kW / year. Small-scale production of a 2 kW mobile PV plant with remote control 10

Scope of application RES, resource-saving, energy-saving technologies IPO degree of protection - Form of transfer rights Technology transfer under a license agreement Readiness degree of development Constructive and engineering documentation prepared. A laboratory technological sample has been developed. Tested in production conditions. Project implementation Implementation Stages 1. Development of technological regulations for production, The period of implementation organization of the release of a pilot batch - 06.2021. 2. Provision of updated proposals for the purchase and manufacture of equipment - 12.2021. 3. Preparation of normative and technical documentation, participation in the start-up and adjustment of the technological line - 06.2022. 4. Small-scale production of a 2 kW mobile PVP with remote control - 12.2022 2021-2022 Need for additional funding, million sum UZS 500.0 million sum for the creation of industrial infrastructure Name of International Solar Energy Institute organization Phone number +99871 235 0344 [email protected] E-mail 11

Institute of Plant Chemistry named after S.Yu.Yunusov ID-4 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Aphrodine is a safe drug with high aphrodisiac activity development Author`s name / academic Candidate of Technical Sciences Y.R.Mirzaev degree PhD Z.I.Sanoev Brief description The main component of the drug aphrodine is the alkaloid donaxin. Chemically, donaxine belongs to the tryptophan storage group of indole alkaloids and is structurally similar to the natural neurotransmitter serotonin (5nt). Aphrodisiac activity was first time identified. Aphrodine (donaxin) is superior to the widely used drug yohimbine in terms of aphrodisiac activity. According to the scientific literature, donaxin belongs to the group of 5nt2s serotonin receptors. Expected results Creating an important drug for substituting import 12

Scope of application Medicine, Andrology, Urology, Psychiatry IPO degree of protection Protected by the Intellectual Property Agency of the Republic of Uzbekistan with 2 patents: IAP 05297 \"Means of aphrodisiac activity\" (10.07.2014) and № 5362 \"Method of obtaining a substance that enhances the work of uterine muscles\" (20.10.1998). Form of transfer rights Through a license agreement Readiness degree of development 1) developed laboratory and technological regulations for the drug \"Aphrodine \" and the method of obtaining the substance; 2) Prepared a temporary pharmacological article: a) Arundo grain - for plant raw materials; b) for the substance of the drug \" Aphrodine \"; c) the raw material base for the drug is sufficiently determined. 3) Scientific and technical documentation on the drug was submitted to the Uz organization and permission was obtained to conduct clinical trials. Certificate of registration DV / M02540 / 05/19 Project implementation Implementation Stages 1. Development of technological regulations for production, The period of implementation organization of pilot batch production – 2021 y. 2. Provide effective proposals for the purchase and production of equipment – 2021 y. 3. Participation in the preparation of regulatory and technical documentation, commissioning and adjustment of production lines – 2022 y. 4. Author's control over technological processes – 2022 y. 2022-2023 years Need for additional funding, million sum 500.0 million sum for the creation of industrial infrastructure Name of Institute of Plant Chemistry organization Phone number +99871262-59-13 [email protected] E-mail 13

Institute of Plant Chemistry named after S.Yu.Yunusov ID-5 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Cyclocardioside - cardioprotective drug development Author`s name / academic Candidate of Agricultural Sciences M.A.Agzamova degree Candidate of Agricultural Sciences A.A.Janibekov Doctor of Technical Sciences R.M.Xalilov. Brief description The drug \"Cyclocardioside\" of cardiotropic activity. Composition: natural individual glycoside - cyclosiversioside F from the Astragalus pterocephalus Bunge plant. Indications for application: prescribed for angina pectoris, coronary heart disease, myocardial infarction, neurocirculatory dystonia, that is, diseases where metabolic disorders are accompanied, both in the myocardium and in the vessels. Advantages: Natural compound, low toxicity (LD50> 3000 mg / kg), not cumulative. Release form: tablets Expected results Creation of technology for the production of cyclosiversiozide F substance from the plant Astragalus pterocephalus Bunge 14

Scope of application Pharmaceuticals Patent of the Republic of Uzbekistan № IAP 2020 0350 IPO degree of protection «Method of obtaining cyclocyversioside F from the surface of the plant Astragalus pterocephalus» Form of transfer rights Through a license agreement Readiness degree of development Preparation of laboratory technological regulations for the production of the substance is underway. The drug was tested under laboratory conditions in 2010- 2012 / in industrial conditions in 2019-2020. At present, experimental-industrial tests are being conducted at the Institute of Plant Chemistry. Project implementation Implementation Stages 1.Proposals for the purchase of equipment – 2020 y. The period of implementation 2.Development of technological regulations of production and production of experimental series - 2021-2022 y. 3.Preparation of normative and technical documents, commissioning of the technological line - 2021-2022 y. 2021-2022 years. Need for additional funding, million sum 1.27 billion sum for the creation of industrial infrastructure Name of Institute of Plant Chemistry organization Phone number +998712625913, +998977421478 [email protected] E-mail 15

Institute of Plant Chemistry named after S.Yu.Yunusov ID-6 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Ecologically clean biostimulator for agriculture \"Uchkun\" development Candidate of Agricultural Sciences Xidirova N.K. Author`s name / academic Candidate of Agricultural Sciences Abdurazzakov A. degree Brief description “Uchkun” biostimulant plants (cotton, wheat, tomatoes, cucumbers, squash, etc.) isolated from cotton leaves increase resistance to diseases, adverse environmental conditions (drought, salinity, etc.), while increasing the yield and quality of the target product, Uchkun in small doses (1 , The use of 0% water emulsion, 1 litre per ton of cotton seeds or 0.05 l / ha) is promising, environmentally friendly and harmless for use in agriculture.The drug is easy to transport and forms stable emulsions with surfactants, which helps to use it in various forms (soaking, moistening, seed capsule, spraying vegetative plants). When 1 liter of 1.0% water-soluble Uchkun emulsion is used per ton of seed, the yield of raw cotton increases by 3.0-3.6 S / ha (10-12.5%). When 0.1 l / ha of seeds are soaked during the growing season, “Uchkun” has a good biological effect on cucumbers. At the same time, the yield of cucumbers and tomatoes increase by 33-35 C / ha (23.8- 33.1%) and 62-65 C / ha (22.8-23.4%), respectively. Expected results When the drug is applied to vegetables and melons, the yield and commercial quality of the product increases. Introduction of a local biostimulator in cotton with an additional yield of 3.6 C / ha, profit from 1 hectar : 2,000,000 sum. 16

Scope of application Resource-saving technologies in agriculture IPO degree of protection Patent for the production of “Uchkun” biostimulator in the Republic of Uzbekistan № IAP 04584 dated 22.10.2012 y. Form of transfer rights License agreement. Readiness degree of development Laboratory regulations were prepared. Experimental and technological regulations for production have been developed. The organizational standard was developed and approved. Recommendations for use have been developed. It has a certificate by the State Chemical Commission for use in cotton, cucumbers and tomatoes. Project implementation Implementation Stages 1.Development of technological regulations for production, The period of implementation organization of experimental and production batches- 01.01.2021-01.09.2021 2. Conducting industrial testing of biostimulants in order to expand the use of vegetables, melons and grains. 3. Author's control of technological processes during the project implementation 2021-2022 years. Need for additional funding, million sum 800.0 million sum for the creation of industrial infrastructure Name of Institute of Plant Chemistry organization Phone number +998712627000 [email protected] E-mail 17

Institute of microbiology ID-7 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Probiotic feed additive \"Baktovit\" for animal husbandry development Author`s name / academic Candidate of Biological Sciences Kutlieva.G.D degree Brief description The probiotic supplement consists of local strains of lactobacilli, propionic acid bacteria, bifidobacteria, and spore bacteria. Advantages: safety, harmlessness, intended for enrichment of feed with biologically active substances: proteins, amino acids, vitamins, etc. Probiotics help to replace feed antibiotics and thus prevent and treat various bacterial diseases. The development and digestion of animals is improved. The productivity of farm animals is increasing. Expected results The production of domestic probiotic feed additives and feed for all branches of animal husbandry will be established 18

Scope of application All branches of animal husbandry, veterinary medicine IPO degree of protection Patent application FAP 2020 0097 Form of transfer rights - Readiness degree of development Laboratory and practical research has been carried out. Positive test certificates were received from livestock farms: fish farming, poultry farming, rabbit farming. Project implementation Implementation Stages 1. Preparation the regulatory and technical documentation of the bio-preservative (Ts - Organization standard, technological instructions for production, instructions for use, development, coordination, approval, harmlessness and safety of the drug, registration in the relevant organizations. (2020-2021) 2. Certification, definition of criteria for environmental safety and product quality, industrial regulations, practical application (2021-2022). The period of implementation 2021-2022 years. Need for additional funding, million sum 1.0 billion sum for the creation of industrial infrastructure Name of Institute of microbiology organization Phone number +99871 2627992, +99890 9504676 [email protected] E-mail 19

Institute of microbiology ID-8 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Mastering the production of the biological product \"Imbiocon\" for development canning and preparation of forage crops Author`s name / academic Candidate of Biological Sciences Kutlieva.G.D degree Brief description In a market economy, the need for different feeds is increasing. This issue can be solved by strengthening the feed base by maximizing the practical use of modern methods of harvesting and storing plant feed, which can dramatically reduce the loss of nutrients reaching the normal harvesting conditions. In this respect, the most advantageous method of obtaining feed from plant raw materials is silage and haying. The silage and hayting of green feeds is accompanied by less nutrient loss, in particular protein (protein). Feed prepared with a bioconservative provides a balanced diet of animals. As well as the ability of the bioconservant to slow down the damage of feed is an important advantage over other drugs. Expected results The domestic drug will be available to all livestock farms. Because it is created on the basis of local raw materials and microorganisms. This product will protect feed from mycotoxins and pathogenic bacteria, improve digestion and digestibility of feed in animals, will help to increase immunity and animal health. As well as increasing the productivity of milk and meat in animals, as feed will be provided with the necessary nutrients (proteins, amino acids, vitamins, etc.). This development contributes to improving and enriching the quality of feed, ensures their safety and thus ensures the safety of animal health, increasing their productivity. 20

Scope of application Agriculture, livestock, veterinary medicine Patents: IPO degree of protection № FAP 0151 № FAP 01493 Form of transfer rights - Readiness degree of development The drug was tested in farms in Tashkent, Namangan and Sirdarya regions. Positive test acts have been obtained. The composition of the drug is harmless, environmentally friendly. Project implementation Implementation Stages 1. Preparation the regulatory documentation of the bioconservative (Ts - Organization Standard, production instructions, instructions for use, development, approval, approval, harmlessness and safety of the drug, registration in the relevant organizations. (2020-2021) 2. Certification, definition of environmental safety and product quality criteria, industrial regulations, practical application (2021-2022). The release of the drug is planned at the company \"All Well Lab\" The period of implementation 2021-2022 years. Need for additional funding, million sum 1.0 billion sum for the creation of industrial infrastructure Name of Institute of microbiology organization Phone number +99871 2627992, +99890 9504676 [email protected] E-mail 21

Institute of microbiology ID-9 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology Technology to obtain a pilot sample of biocatalysis for / development biotransformation of acrylonitrile in acrylamide - \"Rhodoamid\" Candidate of biochemical sciences – Makhsumhanov.A.A Author`s name / Polymers and acrylamide-based polymers are used in many academic degree industries. The demand for flumulants on their basis is especially Brief description growing. Navoiyazot Acrylamide receives a chemical method that is outdated and has a number of economic and environmental Expected results disadvantages. The biocatather \"Rhodomid\" is derived from the enzymatically active cells of actinoberacteria Rhodococcus ruber - 8/4/1. The use of the biocatalyst \"Rhodoamide\" in biotransformation of acrylonitrile will produce 99-100% pure acrylamide. This biotechnology is energy- efficient, mono-stage and environmentally friendly. The use of the biocatalysator \"Rhodoamide\" when receiving acrylamide will reduce the cost of the product by more than 20% compared to the chemical method. The planned science-intensive products will allow in the future to restore the chain of production capacity for the production of acrylonitrile in \"Navoiyazot\" to produce acrylamide (more than 20,000 t/y), eliminates the production of flacula and increases the export potential of the company. 22

Scope of application Chemical industry IPO degree of protection There is a patent of the Republic of Uzbekistan for the enzymatically active strain-producer \"Strain of bacteria Rhodococcus ruber - 8/4/1 - producer of nitrilgidatase.\" No IAP 05723 from 28.12.2018 Form of transfer rights License agreement. Readiness degree of development Tests have been carried out in laboratory and enlarged laboratory conditions. Project implementation Implementation Stages 1. Development of the technological regulation for the receipt of the biocatalyst \"Rhodoamide\" and the organization of the release of the experimental batch – 2021 y. 2. Providing clarified proposals for the purchase and manufacture of equipment – 2021 y. 3. Preparation of regulatory and technical documentation, participation in the launch and installation of the pilot line – 2022 y. 4. Author's oversight of biotechnology processes – 2022 y. The period of implementation 2021-2022 years. Need for additional funding, million sum 300 million sum for the creation of industrial infrastructure Name of Institute of microbiology organization Phone number +99871 2627992, +99890 9504676 [email protected] E-mail 23

Institute of microbiology ID-10 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / “Lactopropolis” is a probiotic drug for the prevention and treatment of development gastrointestinal ulcers and inflammatory diseases Author`s name / academic Doctor of Biological Sciences Miralimova .Sh.M. degree Helicobacter pylori is a gastric pathogen that causes gastric and 12- Brief description finger ulcers and is involved in the onset of stomach cancer. About 50% of the world's population is infected with helicobacter. In Expected results Uzbekistan, the incidence of infections reaches 95%, currently the infection is treated with 2-3 antibiotics, but a complete cure is achieved in only 70% of cases partly due to antibiotic resistance of the pathogen, partly due to premature interruption of treatment due to the toxicity of anibiotics. To solve this problem, the Institute of Microbiology of academy of Sciences of the Republic of Uzbekistan developed a natural drug \"Lactopropolis\" based on lactic acid bacteria and beekeeping products, which, with high effectiveness in the treatment of stomach ulcers, has immunostimulating properties and is absolutely harmless to the human body. Production of the drug and its introduction on the market of Uzbekistan will help to improve the effectiveness of treatment of stomach ulcers, reduce the frequency of relapses, increase the body's resistance to infectious diseases in the pandemic. Providing the population with an affordable, effective and safe means will raise the standard of living of patients and prevent the incidence of healthy people. 24

Scope of application Pharmaceutical industry IPO degree of protection There is a patent of the Republic of Uzbekistan on the way in which the anti-ulcer vehicle No. IAP 05716 is prepared. Form of transfer rights License agreement Readiness degree of development Experimental batches of the drug have been developed and preclinical studies have been carried out. Rooms for production have been prepared, some of the equipment has been purchased Project implementation Implementation Stages 1. Purchase of equipment for the staffing of experimental production of probiotic drugs - 2020 2. Start and set up the pilot line - 2020 3. Production of experimental batches - 2020 4. Obtaining a license to produce dietary supplements and medicines - 2020 5. Preparation of regulatory and technical documentation for dietary supplements and registration procedures - 2021 6. Production and implementation of dietary supplements - 2021 7. Clinical Trials - 2021 8. Registration of Lactopropolis as a drug – 2023 The period of implementation 2020-2021 (bas production), 2020 - 2023 (drug production) Need for additional funding, million sum 1 billion sum for the purchase of equipment and packaging materials Name of Institute of microbiology organization Phone number +99871-241-82-78, +99897 778 63 50 [email protected] E-mail 25

Institute of microbiology ID-11 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / “Atheris” is a biologically active supplement for the prevention and development treatment of hypercolysterolemia Author`s name / academic Nasmetova.S.M degree Brief description The drug is created on the basis of natural statins synthesized by endophyte mushrooms Aspergillus terreus-497, which have antioxidant properties, normalizes lipid metabolism and maintains normal levels of atherogenic lipids (including \"bad cholesterol\"),improves morphofunctional vascular condition. Expected results Local dietary supplements based on natural statins \"Ateris\" will be an alternative to expensive imported drugs. 26

Scope of application Pharmaceutical industry A patent has been obtained for the invention of the Republic IPO degree of protection of Uzbekistan for the strain of fungi Aspergillus terreus-497, synthesizing lovastatin (No. IAP 05086, 2013). Form of transfer rights License agreement. Readiness degree of development Laboratory and experimental and industrial tests have been carried out. The standard of the organization for the production of the drug \"Ateris\" is registered in the Agency \"Uzstandart\" (Ts15011021-011:2018). Project implementation Implementation Stages 1.Testing the technology of the drug ATERIS and creating experimental areas to prepare for large-scale production (2021-2022 y). 2. Develop industrial regulations for semi-industrial production. Production Organization (2023-2024 y). The period of implementation 2021-2024 years. Need for additional funding, million sum 980.35 million sum for introduction into production Name of Institute of microbiology organization Phone number +99871 2627992; (90) 9504676 [email protected] E-mail 27

Institute of Genetics and Plant Experimental Biology ID-12 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Promising variety of cotton UzFA-710 development Author`s name / academic PhD , O.R.Ergashev degree Brief description Due to the organization of agroclusters, the need for promising high quality and fiber output of at least 40% of cotton varieties has increased. In this regard, the expansion of the acreage with high quality and output of fiber (41%) UzFA-710 varieties fully meet the requirements of agro and textile cluster, industrial textiles. The proposed UzFA-710 variety is competitive in the quality and output of fiber, as well as resistance to soil drought compared to other industrial varieties Expected results A high-quality harvest will be obtained, the economic efficiency per hectare will be about 70 - 80 thousand sum. 28

Scope of application Agriculture, clusters, farms, cotton farms IPO degree of protection Received a patent from the Intellectual Property Agency of the Republic of Uzbekistan, No. NAP 00237 05.12.2019 Form of transfer rights Based on the contract Readiness degree of development The variety \"UzFA-710\" is sown in the Fergana region -150 hectares of elite, 40 hectares R 2, in the Tashkent region 12 hectares of super elite, in Karakalpakstan 1 hectare super elite and 6 hectares of elite. A total of 21 hectares of super elite and 156 hectares of elite seeds have been sown. The total area is 217 hectares. Project implementation Stage 1 - breeding of original, elite seeds Implementation Stages Stage 2 - breeding of original, elite and R1 seeds Stage 3 - growing original, elite, R1 and R2 seeds The period of implementation 2021-2022 years. Need for additional funding, million sum 700.0 million sum for the creation of industrial infrastructure Name of Institute of Genetics and Plant Experimental Biology organization Phone number +99893 5034482 [email protected]. E-mail 29

Institute of Genetics and Plant Experimental Biology ID-13 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / New variety of cotton UzFA -715 development Author`s name / academic PhD , J.R.Dadajonov degree Brief description Due to the organization of agroclusters, the need for promising high quality and fiber output of at least 40% of cotton varieties has increased. In this regard, the expansion of the planting area of the high-yielding, high quality fiber variety UzFA-715 fully meets the requirements of agro and textile cluster, industrial textiles. The proposed UzFA-715 variety is competitive in the quality and output of fiber, as well as resistance to soil drought compared to other industrial varieties. The UzFA-715 cotton grade presented in the project is focused on the problems of agro-industrial and textile clusters and successfully passes tests in production. Expected results High-quality harvest will be obtained. 30

Scope of application Agriculture, farms, cotton farms IPO degree of protection Received a patent from the Intellectual Property Agency of the Republic of Uzbekistan, No. NAP 00237 05.12.2019 Form of transfer rights Based on the contract Readiness degree of development The UzFA-715 cotton grade was planted on 10 hectares of elite seeds in the primary seed farm \"Turon\" of the Ishtihon district of Samarkand region. The UzFA-715 cotton grade presented in the project can be competitive and effectively commercialized with high fiber quality and yield compared to standard varieties. Project implementation Stage 1 - breeding of original, elite seeds Implementation Stages Stage 2 - breeding of original, elite and R1 seeds Stage 3 - growing original, elite, R1 and R2 seeds The period of implementation 2021-2022 years. Need for additional funding, million sum 700.0 million sum for the creation of industrial infrastructure Name of Institute of Genetics and Plant Experimental Biology organization Phone number +99893 5034482 [email protected]. E-mail 31

Institute of Genetics and Plant Experimental Biology ID-14 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / ”Gen-24”(Ehtiyoj) Soybean Lines development Author`s name / academic Professor M.F.Abzalov degree Brief description The Line Of “Gen-24” is highly edray with high indicators of protein and oil, bringing to a variety of homogeneity. Expected results A variety (Ehtiyoj) with a yield of 30-40 c/ha will be created 32

Scope of application Agricultural, livestock, pharmaceuticals, medicine IPO degree of protection Environmental clean land and product Form of transfer rights Patent and contract Readiness degree of development 85-90%, created the line Ehtiyoj, medium-nosed, suitable main seeding Project implementation Implementation Stages 2021-2023 The period of implementation 2024-2025 Need for additional funding, million sum Transport for comparative analysis by region, annually 200- 300 million sum Name of Institute of Genetics and Plant Experimental Biology organization Phone number +99871 264 -77-96 [email protected]. E-mail 33

Institute of Genetics and Plant Experimental Biology ID-15 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Promising variety of cotton UzFA-705 development Author`s name / academic PhD , M.R.Kodirova degree Brief description Compared to other industrial varieties, the promising UzFA-705 variety has an advantage in the quality and output of fiber, as well as speed and resistance to soil drought. The promising grade of cotton UzFA- 705 has a pre-property in the quality and output of fiber for the industry. When breeding in the production of a new grade of cotton, by increasing yields by 3-4 c/ha, output of fiber by 2% and improving the quality of fiber (industrial type) economic efficiency per hectare of planting material will be about 60 - 70 thousand sum compared to standard varieties in production. The introduction of the variety in Uzbekistan, subject to the norms of agricultural engineering, will allow to receive a high yield (35-60 c/ha) of raw cotton. This variety has a compact bush structure, I.5-II type of branching, fiber length 34.0-34.5 mm, microneur 3.9-4.2 and fiber output 37-39% refers to type IV, the mass of raw cotton of one box 6.0- 6.5 g, the beginning of the opening of the first box 117-12 days. The UzFA-705 variety belongs to the medium-ripe group of varieties with a high rate of box opening and has a high morphological homogeneity. Expected results A high-quality harvest will be obtained, the economic efficiency per hectare will be about 60 - 70 thousand sum. 34

Scope of application Agriculture, clusters,farms, cotton farms IPO degree of protection Received a patent from the Intellectual Property Agency of the Republic of Uzbekistan, No. NAP 00253 05.12.2019 Form of transfer rights Based on the contract Readiness degree of development Since 2015, it has been recognized as a promising variety in the Surkhandarya region. It breeds in the primary elite farms of Tashkent and Surkhandarya regions. Project implementation Stage 1 - breeding of original, elite seeds Implementation Stages Stage 2 - breeding of original, elite and R1 seeds Stage 3 - growing original, elite, R1 and R2 seeds The period of implementation 2021-2022 years. Need for additional funding, million sum 700.0 million sum for the creation of industrial infrastructure Name of Institute of Genetics and Plant Experimental Biology organization Phone number +998993591356 [email protected] E-mail 35

Institute of Bioorganic Chemistry named after O.Sodikov ID-16 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / «Apicapsalvin»- an anti-inflammatory drug development Author`s name / academic Candidate of chemical science Ziyovutdinov.J.F degree Brief description The anti-inflammatory drug Apicapsalvin for external use has been Expected results developed. It contains grape oil, bee venom, capsaicinoids and salicylic acid methyl ester. Selected and balanced components provide Apikapsalvin liniment with the following properties: • long-term warming; • analgesic and anti-inflammatory effect; • soft and deep heating of tissues in case of joint inflammation; • reduction of the period of exacerbation of chronic inflammatory diseases of the musculoskeletal system. Apicapsalvin is not toxic in the applied dose, does not have a cumulative property, has a weak irritant effect, and increases the permeability of skin capillaries. It surpasses the commercial drug \"Apizartron\" in its anti-inflammatory effect. Apicapsalvin, being a highly effective anti-inflammatory drug, is being developed on the basis of a substance obtained from local raw materials, which will lead to a decrease in the cost of the developed drug and will provide in the future the need of the Republic for an anti- inflammatory drug for external use, create the possibility of import substitution and export expansion. 36

Scope of application Pharmaceuticals and medicine IPO degree of protection VFS for the dosage form - liniment \"Apikapsalvin\", and the substance \"Capsaicinoids\" are registered in GUKKLS and MT MH RUz under No. 42 Uz-1470 - 2014 and 42 Uz-1471 - 2014. Form of transfer rights Lisence agreement Readiness degree of development The substance \"Capsaicinoids\" and the liniment \"Apikapsalvin\" by the order of the Ministry of Health of the Republic of Uzbekistan No. 329 dated October 30, 2009 are allowed for widespread use in medical practice. Project implementation Implementation Stages The production of the substance \"Capsaicinoid\" is planned to be organized on the basis of the Institute, the dosage form Apikapsalvin in one of the enterprises of the State Joint-Stock Company \"Ozpharmsanoat\" The period of implementation 2021-2022 years. Need for additional funding, million sum The need for financing is 250 million sum. Of these, 125 million sum for the organization of the production of a substance and the development of scientific and technical documentation, 125 million sum for the organization of the production of a dosage form. Name of Institute of Bioorganic Chemistry organization Phone number +99871 262-35-40 [email protected] E-mail 37

Institute of Bioorganic Chemistry named after O.Sodikov ID-17 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / \"BIOCOR\" (tablet 0.2 g) immunomodulator with antitumor properties development Doctor of Biological Sciences Ibragimov F.A. Author`s name / academic degree Biokor preparation is a purified standardized combination of soy flour polypeptides.Biocor is an immunomodulator, based on preclinical Brief description studies, it can be used for the complex treatment of oncological diseases of melanoma, rectal cancer, breast cancer, uterine Expected results endometrial cancer. The drug reduces the toxic effect of other types of treatment (chemotherapy and radiation therapy), normalizes the immune system, improves hematological and morphological blood parameters (reduces the percentage of leukocytes, increases the level of granulocytes, hemoglobin and erythrocytes), and prevents metastasis.The drug Biokor belongs to the V class of practically non- toxic compounds, does not possess cumulative, locally irritating, allergenic and mutagenic effects. Biocor does not have a toxic effect on peripheral blood, kidney and liver function.Method of administration and dosage. The drug is prescribed on the third day after basic therapy. It is recommended to take four tablets per day. The course of treatment is 10 days. The course is repeated according to the repetition of the basic therapy courses. The planned high-tech products for the production of Biokor - (tablet- 0.2 g) reduces imports by 20%, and the products developed on their basis are sent for export. Production efficiency increase is 20%. 38

Scope of application Pharmaceuticals and medicine IPO degree of protection Patented- No. IAP 04501. Protein from soybean meal with anticancer activity and a method for its isolation / Ibragimov FA, Beresneva Yu.V., Salikhov Sh.I., Kuznetsova NN, Kireev G.V. , registered in the State Register of Inventions of the Republic of Uzbekistan, Tashkent city 26.04.2012 Form of transfer rights Lisence agreement Readiness degree of development Laboratory regulations prepared / standard approved. Developed laboratory technological regulations for the production of Biokor substance. Tested under laboratory / production conditions. Project implementation Implementation Stages Development of technological regulations for production, organization of the release of a pilot batch – 2023 The period of implementation 2023 year Need for additional funding, million sum UZS 500.0 million sum for the creation of industrial infrastructure Name of Institute of Bioorganic Chemistry organization Phone number (71)262-35-40 [email protected] E-mail 39

Institute of Bioorganic Chemistry named after O.Sodikov ID-18 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / \"Biomairin\" - a combined long-acting anti-tuberculosis drug development Author`s name / academic Doctor of chemical science- Shomurotov.Sh.A degree Brief description Biomairin - has an antibacterial, anti-tuberculosis effect, is active against Mycobacterium tuberculosis at different stages of development. The combined use of the active substances that make up the drug reduces the risk of developing resistance, which develops with monotherapy. The drug will be the only original drug against tuberculosis diseases Expected results produced by local manufacturers. Reduces the import of anti-tuberculosis drugs from abroad. 40

Scope of application Medicine IPO degree of protection There is a patent of the Republic of Uzbekistan \"Method of obtaining a polymer conjugate\", No. SAP 2015 0261, June 29, 2015 There is a certificate for the trademark and service mark \"BIOMIRIN\" No. MGU 2017 2360 Form of transfer rights Lisence agreement Readiness degree of development The technological regulations for the production of the substance and dosage form in the form of a capsule have been developed. A draft of a temporary pharmacopoeial monograph for the substance and dosage form has been developed. The first stage of clinical trials of the drug was carried out in the specific organisation. Project implementation 1.Conducting 2 and 3 stages of clinical trials - 2021-2022. Implementation Stages 2. Approval of ND (regulations and VFS) - 2022. 3. Obtaining permission to use - 2022. The period of implementation 2021-2022 years Need for additional funding, million sum 800.0 million sum for conducting 2 and 3 stages of clinical trials Name of Institute of Bioorganic Chemistry organization Phone number (71) 262-35-40 [email protected] E-mail 41

Institute of Bioorganic Chemistry named after O.Sodikov ID-19 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Biosolvent - preparation for effective reclamation of saline soils development Author`s name / academic Academic, Turayev.A.S degree Brief description Biosolvent is a polymer composition containing a polymer and a surfactant. The biosolvent is used for washing saline soils. When flushing highly saline soils with Biosolvent, the level of soil salinity is reduced by almost two times compared to flushing with ordinary water. Water consumption for leaching is reduced 2-3 times and soil fertility is improved. Expected results The use of the Biosolvent preparation will increase the yield of agricultural crops by 10-15% and reduce the salinity of soils by half. 42

Scope of application Agriculture There is a patent of the Republic of Uzbekistan IPO degree of protection Patent RUz No. IAP 05649. \"Composition for soil treatment\". 08/20/2018. Form of transfer rights Lisence agreement Readiness degree of development Laboratory regulations prepared / standard approved. The laboratory technological regulations for production facilities have been developed. Tested under laboratory / production conditions. Project implementation Implementation Stages Conclusion of contracts The period of implementation 2021-2022 years Need for additional funding, million sum UZS 500.0 million sum for the creation of industrial infrastructure Name of Institute of Bioorganic Chemistry organization Phone number +99871 2623540 [email protected] E-mail 43

Institute of Bioorganic Chemistry named after O.Sodikov ID-20 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / “Gemogubka\" - hemostatic collagen sponge development Author`s name / academic Rajabov.O.I degree Brief description As a hemostatic agent for capillary and parenchymal bleeding, filling defects of parenchymal organs. Expected results The use of hemostatic devices is expanding. 44

Scope of application Medicine IPO degree of protection There is a patent of the Republic of Uzbekistan Patent No. IAP 04736 \"Method for producing collagen substance\" Patent No. IAP 04736 \"Method for producing collagen spongy material\" Form of transfer rights Lisence agreement Readiness degree of development Registration certificate TV / M 00104/12/16 of 02.12.2016 was received and allowed for use in medical practice. Project implementation Implementation Stages Obtaining prototypes of a hemostatic device Conducting a study on the use of a hemostatic device in dentistry. Preparation of normative and technical documentation The period of implementation 2021-2022 years Need for additional funding, million sum 500.0 million sum for the creation of industrial infrastructure Name of Institute of Bioorganic Chemistry organization Phone number +99871 2623540 [email protected] E-mail 45

Institute of Bioorganic Chemistry named after O.Sodikov ID-21 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Hemostatic drug for local use - Glilagin development Author`s name / academic Doctor of chemical science- Matchanov.A.D degree Brief description The hemostatic preparation Glilagin is exclusively plant-based. The supramolecular complex of lagochilin is the main active ingredient of the Lagochilus Inebrians plant with the monoammonium salt of glycyrrhizic acid, the main active ingredient of the licorice plant. The Provisional Pharmacopoeia Monograph for the Glilagin substance was approved. VFS 42 Uz-3123-2017. The mechanism of the hemostatic action of the drug Glilagin is associated with its effect on vascular- platelet hemostasis. An increase in the number and adhesive - aggregation ability of platelets in the blood. Along with the activation of the platelet system, there is a decrease in capillary permeability, which leads to an increase in the retraction of the formed clot. Expected results 1. Organization of the release of an experimental batch of a substance and a dosage form - 2021 2. Provision of updated proposals for the purchase and manufacture of equipment - 2021 3. Preparation of regulatory and technical documentation, participation in the start-up and adjustment of the technological line - 2022 4. Conducting field supervision of technological processes - 2022 46

Scope of application Pharmaseutical and Medicine IPO degree of protection - Form of transfer rights Lisence agreement Readiness degree of development Regulatory and technical documentation of the drug Glilagin approved. A permit for practical medicine was obtained. Project implementation The production of the substance and dosage form will be Implementation Stages established at the experimental base of the Institute of Bioorganic Chemistry. The period of implementation 2020-2022 years Need for additional funding, million sum 1 billion sum for the creation of industrial infrastructure\\ Name of Institute of Bioorganic Chemistry named after O.Sodikov organization Phone number +998 93 5797919 [email protected] E-mail 47

Institute of Bioorganic Chemistry named after O.Sodikov ID-22 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Hemostatic drug for intravenous use - Lagovin development Author`s name / academic Doctor of chemical science Matchanov.A.D degree Brief description Hemostatic drug Lagovin based on plant raw materials. The Expected results supramolecular complex of lagohilina is the main active substance of the Lagochilus Inebrians plant with polyvinylpyrolol. The Temporary Pharmacopeia article on the substance Lagovin VFS 42 Uz-3120-2017 has been approved. The mechanism of hemostatic action of the drug Lagovin is associated with its effect on vascular-platelet hemostasis. Increased blood quantity and adhesive - the aggregation ability of platelets. In addition to activation of the platelet system, there is a decrease in the permeability of capillaries, which leads to an increase in the retremality of the resulting clot. 1. Organization of the production of an experimental batch of substance and medicinal form - 2021 2. Providing clarified proposals for the purchase and manufacture of equipment - 2021 3.Preparation of regulatory and technical documentation, participation in the launch and installation of the technology line - 2022 4. Author's Oversight of Technological Processes - 2022 48

Scope of application Pharmaceuticals and Medicine IPO degree of protection Patent for inventions No. IAP 04806. Also, IAP 2009 0404. which have hemostatic effect. Form of transfer rights Lisence agreement Readiness degree of development Regulatory technical documentation of the drug Gleylagin approved Received permission for practical medicine. Project implementation Production of the substance and drug form will be Implementation Stages established on the experimental basis of the Institute of Bioorganic Chemistry. The period of implementation 2020-2022 years Need for additional funding, million sum 1 billion sum for the creation of industrial infrastructure Name of Institute of Bioorganic Chemistry organization Phone number +998 93 5797919 [email protected] E-mail 49

Institute of Bioorganic Chemistry named after O.Sodikov ID-23 CATALOG of scientific developments and innovative projects for further commercialization Name of the technology / Gossipol Pharmacopeic development Author`s name / academic degree Brief description Gossipol, a polyphenol isolated from cotton seeds, is a fine crystalline powder of yellow color with a greenish tinge. The polyfunctional state of the state sipol causes a wide range of its physiological activity, on its basis more than 300 derivatives are synthesized and their biological activity depends on the structure.Gossipol and its derivatives have anticancer, antiviral, immunomodulating, interferonizing activity. Gossipol is used in the pharmaceutical industry as a substance for the creation of medicines. Gossipol is produced on the experimental basis of the Institute of Bioorganic Chemistry. Every year the Institute exports 100 to 300 kg of pharmacopeia state sipol. The organization of low-capacity production will fully meet the needs of Expected results the domestic market and significantly increase exports abroad to 300 - 500 kg annually. 50


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