CU Innovations Newsletter Spring / Summer 2019

Spring / Summer 2019 CU INNOVATIONS UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS BRINGING IDEAS TO NEW HEIGHTS The Future of Healthcare 3D Printed Heart Models by Inworks Digital Health Explosion Virtual Reality Care

Welcome to the CU Innovations Spring / Summer 2019 Newsletter! Welcome to the Spring / Summer 2019 CU Innovations Newsletter, a collection of news on healthcare innovation, inventor resources, and strategic partnerships across the University of Colorado Anschutz Medical Campus. This publication brings forth the groundbreaking CU Anschutz ideas that forge a new landscape in healthcare. The CU Anschutz campus continues to be a leading center for healthcare innovation worldwide. Construction commenced on the new Anschutz Health Sciences building on January 30th, 2019 and is scheduled to open in mid-2021. The new 390,000 square foot facility will add space for education, research, and clinical programs in a stunning seven-story design. The future focused building will be a centerpiece for collaboration where leaders, entrepreneurs, researchers, and other thinkers work together to create breakthrough ideas in healthcare. We've been able to see the impact emerging technology has on advancements in healthcare. 3D heart models printed by Inworks helped to reduce risks during surgery for Max Mitchell, MD, a pediatric surgeon and 2018 SPARK fellow. Inworks and Dr. Mitchell collaborated to create functional heart models to prepare for a complex cardiovascular surgery. We're proud to celebrate 15 faculty members who have been selected as SPARK fellows for 2019. The new fellows have created some of the best innovations across the Anschutz Medical Campus. It is an exciting time to be part of an innovative community focused on creating solutions to transform healthcare. Whether you are a student, faculty, or researcher, we have the resources to help you advance your ideas. To our outside partners, we are here to connect you to the latest CU Anschutz technologies. Partner with us to forge the future of healthcare. Sincerely, Kimberly Muller, Esq. Executive Director, CU Innovations

3 5 11 CONTENTS 3 Innovation Spotlight 15 Innovation News Getting to the Heart of the Matter EIR - Richard Foster 5 Innovation Spotlight 16 Innovation News Spring 2019 Innovator - Malik Kahook, MD Care Innovation Center 7 Innovation News 17 Innovation Spotlight CU Anschutz on Forefront Congratulations 2019 SPARK Fellows of Reimagining Health Care 19 Education And Outreach 9 Innovation News Women In Innovation Speaker Series 2018 Grubstake Fund Awards 20 CU Innovations Team 11 Innovation News IP Law Update Pediatric Innovation Challenge 21 Resources 13 Innovation News Funding Opportunities | Upcoming Events Virtual Reality for Behavioral Health CU Innovations brings together industry partners, entrepreneurs, PUBLISHER | EDITOR IN CHIEF CONTRIBUTORS and investors to help CU Researchers solve important problems Joleen Deisler Chris Casey and improve the quality of life worldwide. With expertise in patents, Francis Greennleaf copyrights, and licensing, we help translate discovery into impact ART DIRECTOR | EDITOR James Parrett through transparent, flexible, best practice intellectual property Rolfe Bautista Stephanie So management services. We connect researchers at CU Anschutz Medical Campus with a variety of commercialization programs in the COPY DIRECTOR PRODUCTION university and the community. Cigdem Benam, PhD CU Printing Services Partner with CU Innovations: 303-724-4003 | [email protected] http://innovations.ucdenver.edu Spring / Summer 2019 2

INNOVATION SPOTLIGHT GETTING TO THE HEART OF THE MATTER INWORKS COLLABORATION CREATES RAPID PROTOTYPING FOR ANSCHUTZ INNOVATOR BY STEPHANIE SO Heart models above were created by Inworks to aid Dr. Mitchell in preparing for a complicated heart procedure. Photos of heart models provided by Advanced Imaging Lab at Childrens Hospital/Dr. Barker and Team.

mong the projects of Albensleben, Dr. Martin Ruciman, Dr. able “to pinpoint within millimeters Inworks, a joint innovation Dale Burkett, Dr. Michael DiMaria, and where they were in the heart.” In the initiative of the University radiologist Dr. Lorna Browne—might next day surgery, Dr. Mitchell found of Colorado Denver and have a better idea of what to expect he needed to be exactly where during surgery. the model had predicted, which Athe Anschutz Medical eliminated a certain amount of risk for The request for a custom model the patient during the procedure. Campus, one remains close to the didn’t spring up overnight. For several heart. That is, the literal hearts from months, Inworks designers Nick According to Nick Jacobson, “the Inworks’ high-end polyjet printer, Jacobson and Hayden McClain, magic of 3D printing is that ideas which produces 3D model organs for a CU Denver graduate student in can be prototyped quickly and surgical planning. For a young patient mechanical engineering, collaborated inexpensively, making it easier to of Max Mitchell, MD, the model hearts with surgical teams at Children’s test out new concepts and ideas,” served as illustrative surgical tools Hospital Colorado. What began as which “puts the power of innovation and a showcase of the collaboration an invitation to observe Dr. Mitchell, directly in the hands of those who between doctors and designers. Dr. DiMaria, Dr. Browne, and other have the best understanding of the surgeons, evolved into sessions problems that need to be solved.” In Associate Director Monika Wittig where Jacobson and McClain this case, both surgeon and patient describes Inworks as the pre-pipeline brought in models and discussed benefited from the customizable to CU Innovations’ ecosystem. Where with doctors how to refine and nature of 3D printing and how it fits doctors and clinicians work with CU improve them to better serve as hand-in-hand with treating congenital Innovations to refine and hone their surgical tools. diseases. The outcome epitomizes ideas for commercialization, Inworks Inworks’ emphasis on human- is where those ideas first come to life. When Dr. Mitchell made his patient- centered design—improving patient Budding inventors can collaborate specific request, about a week care and outcome and developing with Inworks designers to create before the scheduled surgery, tools tailored for the end user—as the animations, 3D models, virtual reality McClain was so experienced in designers continually push the limits simulations, and other prototypes. of what is possible. \"...both surgeon and patient benefited from the In addition to patient-specific cases, customizable nature of 3D printing and how it fits Inworks is also a maker workshop hand-in-hand with treating congenital diseases.\" where physicians can prototype their ideas and, when suitable, gain That dedication to cutting-edge the anatomy and process that he traction towards commercialization. technology and collaboration drew transformed the CT scans and patient To do so, Inworks continues to Dr. Mitchell to proposition Inworks data into models within 72 hours. grow its working relationship with for a customized approach to his After a design session where the CU Innovations to create the most patient’s dilemma. doctors practiced and planned their successful outcome by collaborating surgery with the models, Jacobson from the start and merging Inworks’ As a pediatric congenital cardiac and McClain delivered a second set, design expertise with CU Innovations’ surgeon, Dr. Mitchell is well-versed customized for view planes, cross administrative and operational in difficult cases but wanted to take sections, and access points based on resources. extra precautions for a patient with the doctors’ feedback. The designers Wolff-Parkinson-White syndrome. also used their firsthand knowledge To learn more about Inworks: Cardiac ablation would correct of the surgeons, like Dr. Mitchell’s visit www.inworks.org, email the patient’s tachycardia, but prior position at the right side of the [email protected], or call procedures found that traditional patient’s chest, to tailor their models (303) 724-4120. Walk-in hours catheterization was ineffective. to mimic the surgical experience as Further surgery would be necessary, closely as possible. at the Strauss Library, and, based on the patient’s organ daily from 10 am to 3 pm. structure, incisions would be difficult In preparing for the operation, the to predict and hard to place. Dr. model was used with the echo probe Mitchell approached Inworks to print and the intracardiac navigation a model of the patient’s heart so that system and overlaid on the MRI he and the team—cardiologists Dr. study. Combining these techniques, Kathryn Collins, Dr. Johannes Von Dr. Mitchell recalled the team was Spring / Summer 2019 4

INNOVATION SPOTLIGHT SPRING 2019 INNOVATOR MALIK KAHOOK, MD, PROFESSOR OF OPHTHALMOLOGY LEARNING FROM THE SUCCESS OF A FACULTY INVENTOR INTERVIEW BY CIGDEM H. BENAM, PHD You have multiple patents and inventions, what led to your focus on translational research? One of the luckiest events that happened in my professional life was matching at the University of Colorado for residency. I remember coming here for the interview and thinking that the department was very focused on the patient. That spoke to me, as I wanted to build a strong foundation with exposure to a wide range of pathology. When I started my training here, it became evident that the faculty was very talented and innovative. Many of the physicians who trained me are now my colleagues. They were always encouraging me to seek answers for unmet needs in ophthalmic care. CU was really the launching pad for my career as an inventor. How has your environment shaped your career in innovation? CU Innovations has launched a new platform to The University of Colorado Anschutz Medical Campus celebrate the discoveries of faculty inventors is an exciting place to work as a clinician-inventor. In as well as to create venues for peer learning. any given week, I am able to see patients in clinic, The first interview of the Innovator Spotlight perform cutting edge surgery in our operating rooms Series is with Dr Malik Kahook, who is one while also keeping up with the device innovation that of the most prolific inventors and entrepreneurs on the our department is known for internationally. Having the Anschutz Medical Campus. ability to see patients and perform surgery allows me to contemplate how we might improve on our current You have an impressive CV, can you tell us about your practices. background? What have you found most challenging about the When it comes to training and background a lot of times inventive process and developing an idea from concept inventors talk about their basic science or engineering to product? background. My foundation was very different, I was trained as a nurse (BSN) prior to entering medical school. One of the most challenging aspects of mixing clinical I believe my experience as a nurse has allowed me to practice with innovation is managing my time. My work view problems and unmet needs from a unique angle. often requires travel which, at times, can be extensive. I also participate in training of our glaucoma fellows and have a leadership role in multiple clinical trials. If you add up all of the time between patient care and research, you might wonder where the time for innovation comes from! While time management is a challenge, the process is a joy and I wouldn’t trade it for anything. What are the key requirements of success for academic entrepreneurship? 5 CU INNOVATIONS | UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

One of the keys to successful don’t have silos between the bench DR. MALIK KAHOOK innovation is the supportive and the bedside in our department. INNOVATOR environment that exists on campus. Drs. Mandava and Petrash make We have one of the most innovative sure the lines of communication are ACHIEVEMENTS campuses in the country. I have always open. travelled across the globe, visiting In the Top 50 of universities that also have innovation What do you find most rewarding The Ophthalmologist's as their central asset. I would put about mentoring? the University of Colorado at the Power List 2019 top of the list both inside the US as One of the central aspects of well as internationally. The success success as an inventor is having 68 of innovators on our campus starts access to a roadmap of how other at the top with great leadership, inventors succeeded in the past. Invention Disclosures from Chancellor Elliman and Dean Mentorship allows new investigators/ Reilly as well as my Department inventors to learn from the mistakes 42 Chair, Naresh Mandava. Our campus and successes of those who came leadership is supportive both with before them and our department is Issued Patents words and deeds. It must also be active in fostering such relationships. (Foreign & US) noted that the patient is always at I have mentored a few of my the center of what we do. Being on colleagues in aspects that include Patents: an active medical campus with world basic career development as well as class hospital facilities is a constant navigating the innovation pathway Non-invasive device for lowering reminder of why we must succeed from concept to application. I take intraocular pressure in finding new therapies and ways to the responsibility of mentorship cure diseases. seriously and have been working Shape memory polymer diligently to improve my skill set in intraocular lenses Ophthalmology is the number this arena. I believe true mentorship one department in innovation. evolves with time and I hope to be a Modular intraocular lens What makes this department the valuable asset to those who seek my designs and methods hotbed of innovation, what are the guidance. specific practices you have in the Intraocular device for dual incisions department to support innovation What advice would you have for Nasolacrimal implants and related that others can learn from and junior physicians/scientists who emulate? would like to move discoveries methods for tear stimulation  from bench to bedside and make a The Department of Ophthalmology difference in patients’ lives? Licensees: has many innovative minds tackling problems ranging from new surgical The best advice I could give is to Alcon Laboratories, Inc. devices to novel disease targets that reach out to those that have done it Carl Zeiss Meditec, Inc. address unmet needs. It really starts before you. Grabbing a cup of coffee Johnson & Johnson Vision from the top, in our case with the and listening to the experiences New World Medical, Inc. chair Dr. Naresh Mandava. He is a of trusted colleagues is easy to do Shape Ophthalmics, LLC very supportive role model for all of and the benefits can be enormous. us and understands how to cultivate I would advise young inventors to ShapeTech, LLC an environment of cooperation and engage with several colleagues that driving towards a common goal. have more experience and gather Spring / Summer 2019 6 One of the other aspects of the pearls from all. You can take the department that drives success best of each encounter and end up is that our clinicians and basic traveling along a unique pathway scientists interact often and discuss that is all your own. how collaboration can lead to new solutions for long-standing problems Watch the interview: in eye care. Mark Petrash, PhD leads our basic science team and has http://bit.ly/IS-SP2019 been a mentor for several faculty members on the clinical side. We

INNOVATION NEWS CU ANSCHUTZ ON FOREFRONT OF REIMAGINING HEALTH CARE OUR EXPERTS VIEW FAST-GROWING DATA SCIENCE, VENTURE CAPITAL AS KEY DISRUPTORS BY CHRIS CASEY Amid spiraling costs, complexity and inefficiencies, the health care industry has reached an inflection point. It’s ripe for massive disruption. Fortunately, the digital technology revolution is also on the rise, and it offers cutting-edge solutions to the problem. Digital health, remote monitoring systems and prescriptive analytics are just a few ways technology is intersecting with health care. Painting this picture were Richard Zane, MD, professor and chair of the Department of Emergency Medicine in the University of Colorado School of Medicine, and Kimberly Muller, Executive Director of CU Innovations. They presented the many ways the CU Anschutz Medical Campus is at the forefront of innovation and reimagined health care to about 50 members of the Metro Denver Executive Club at the Denver Country Club. 7 CU INNOVATIONS | UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

“What’s going to happen in the next two years, or 10 years, will fundamentally alter the way in which we deliver care, the way in which you get care, and the relationship of industry to health care,” Zane said. Sobering statistics said, if doctors instead could use Richard Zane, MD a tool that easily culls prescriptive After running through sobering analytics from a patient’s electronic “We have the entire continuum — statistics — health care costs the medical record. It would scour each pediatrics all the way to geriatrics average American $10,000 per year person’s record, learn everything — and that broad system represents (a total of $3.5 trillion), and medical about the patient and match a drug every setting in health care. We error is the nation’s No. 3 cause of to the diagnosis. “With the click of a have an academic medical center, death — Zane showed the arc of button, we know the medicine that community hospitals, urgent care, technological advancement and I just prescribed is not only the right clinics and at-home settings,” noted that leading companies — one, but your insurance will cover it Muller said. “Imagine if we use Google and Amazon among them and the pharmacy has it,” he said. this large system as a Clinical — are now putting health care in Validation Laboratory to test all of the crosshairs. By aggregating the And what about soon-to-come 5G the technologies that Dr. Zane talked barriers to care, wastefulness in the digital connectivity, which will further about. In fact, that’s what we’ve been system and care outcomes, they are revolutionize the many wearable building.” beginning to deliver solutions. biometric-monitoring devices on the market? “It’s a game-changer,” The Clinical Validation Lab has Zane, who is also Chief Innovation Zane said. “Maybe we can develop received interest from hundreds of Officer at UCHealth, noted that a patch that costs $30 to make and companies and is regarded as a Google’s Verily has launched lasts for three months. You put it on, national model for accelerating the Project Baseline, which monitors collect all your biometric data. Then transfer of world-class research and everything about a person — all of a sudden, like air traffic control, ideas to the marketplace. respiration, heartbeat, reactions doctors will be able to see all their to environmental conditions, patients and figure out who does Side-by-side collaboration etc. Project Baseline collects so and doesn’t need care.” much data that it will create a new “Now you truly have the definition of a healthy human, he Turning game-changers into reality convergence of technology said. companies coming together, working Muller said the goal of CU side by side with clinicians, to figure But can the human brain interpret Innovations is to take these game- out how we get those adoptions (by all of this data? “I don’t think so,” changing visions and turn them into physicians and patients) and turn that Zane said. “By 2025 knowledge is reality. She noted that venture capital technology failure rate on its head,” expected to double every 12 to 14 is growing exponentially in health Muller said. hours. The only way we’re going to care, but a problem remains: Many of deal with this is by partnering with the advancements are occurring in She added that by studying every machines. We have to figure that silos, separate from the point of care major vertical within health care out: How we use data science, and within health systems. — payers, device manufacturers, how we can allow electronic medical pharmaceuticals, etc. — CU records to help us.” Kimberly Muller, Executive Director Innovations has a holistic vision of of CU Innovations, explained the industry and understands how Information at fingertips the importance of technology technologies can be best advanced. companies and clinicians working For example, technology offers side by side, as they do at the CU “We continue to form partnerships promising solutions to the Anschutz Medical Campus, to forge with health systems around the prescription-drug conundrum. innovations. country, so we can take the work Currently, a couple variables mainly happening here and scale it quickly, factor into the drug a physician Some research shows that as many instead of the 20-year cycle that prescribes a patient, Zane said. They as 95 percent of new health care we’ve traditionally seen in health are: was this medicine effective technologies are never adopted in care,” Muller said. in another patient I treated with a a clinical setting, she said. That’s similar condition, and can I properly where CU Innovations and the CU spell the drug’s name? Imagine, he Anschutz Medical Campus comes in. Spring / Summer 2019 8

INNOVATION NEWS Gates Grubstake 2018 GRUBSTAKE FUND AWARDS BY MICHAEL BOOTH Ken Liechty, M.D. Prevention and treatment of pulmonary fibrosis Acute lung injury leading to Acute Respiratory Distress Syndrome (ARDS) causes 150,000 adult ICU admissions and 75,000 deaths annually in the US. Currently, treatment for ARDS is palliative, and does not address the underlying causes. Dr. Ken Liechty and his team have shown that their nanoparticle therapy is able to regenerate healthy lung tissue in a mouse model of acute lung injury. The Grubstake Award will allow them to develop an inhaled version of the nanoparticle therapy and do the additional safety studies required prior to a clinical trial in ARDS patients. Kunhua Song, Ph.D. Heart regeneration by conversion of non-myocytes into functional cardiomyocytes Almost eight million Americans suffer a heart attack annually; that is about 3% of adults in the US. The annual cost for treating heart attacks is $12 billion, making it the most expensive condition treated in hospitals in the US. Even worse, 30-40% of heart attack patients develop heart failure, accounting for about 50% of all heart failure patients. The five-year survival rate for heart failure patients is only 50%. Despite the development of various therapies and medical devices such as the Left Ventricular Assist Device, the five-year survival rate has not changed in the past 20 years. Dr. Kunhua Song and his team have discovered a way to regenerate healthy cardiac cells from the fibrotic tissue causing heart failure using a gene therapy approach. The Grubstake Award will allow them to complete their animal studies and begin preparing to file an IND to enter clinical trials. Mike Verneris, M.D. Engraftable hematopoietic stem cells from induced pluripotent stem cells, Bone marrow transplants are a high risk, expensive procedure (>$13 billion) used to treat leukemia, lymphoma, and genetic diseases. Two thirds of patients receive transplants from unrelated donors which causes delays to find matching donors, and increases the complications and cost associated with the procedure. Recently, scientists have discovered how to create induced pluripotent stem cells (iPS cells) from a patient’s own cells, expand them, and convert them to bone marrow cells. However, these cells have not been successful at engrafting into the bone marrow in mouse models, indicating they would not be effective in a bone marrow transplant in patients. Dr. Verneris and his team have discovered that adding a small molecule during the conversion of the iPS cells allows engraftment of the cells in the mouse model. The Grubstake Award will allow them to confirm their initial finding in animal models, and to determine the most promising small molecule for clinical and commercial use. 9 CU INNOVATIONS | UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

he Gates Grubstake • Cell biology and tissue Success Fund made enormous engineering strides in 2018 in guiding 2014-2018: the promising science The Grubstake Fund typically awards three researchers each year with $3.5M Tat CU Anschutz Medical a multi-year grant of $350K. The selection process gives weight to Total Investment Campus toward commercialization projects that appear within five years and tangible benefits for patients. of launching a clinical trial. In addition 11 to funding, the structure set up by The Grubstake Fund is meant to Gates, CU Innovations and other regenerative medicine bridge the “valley of death” funding supporters provides: projects received awards gap that separates a promising medical concept from a product • Access to the “Startup Toolbox” 5 that will improve human lives. resources developed by Gates Center Advisory Board member pre-IND packages “The Grubstake program has been Ann Sperling and colleagues. in preparation game-changing as far as impact and getting research to patients,” • Mentoring by business experts $18M said Kim Muller, Executive Director on- and off-campus for pathway of CU Innovations. Over the past and business plan development. follow on funding three years eleven awards have been granted. Five of these projects • Coaching through the regulatory For application assistance are preparing to enter the clinic. process required by the Food & and questions contact: The amount of follow-on funding Drug Administration and other Heather Callahan shows the success of the Grubstake compliance offices in drug or program, a five times return on device development. [email protected] investment. “We are looking at using Spring / Summer 2019 10 that model for all therapeutic areas • Access to SPARK Colorado run around campus. We almost feel we through CU Innovations. have an ethical obligation to do it,” Muller added. This year’s Grubstake Award application process will begin in There are at least 105 ongoing June, with written applications due regenerative medicine projects on at the end of August. Interested campus with potential to compete applicants are encouraged to for Grubstake awards of which 25 reach out to the Gates Center’s of those have reached the product Entrepreneur in Residence, Heather development stage. As word spreads Callahan, for guidance during the of the program’s opportunities for application process. researchers, applications for the handful of awards have become increasingly competitive. The Grubstake Fund is focused on accelerating research in the field of regenerative medicine, with the potential for direct patient impact. Research eligible for award includes projects having proof of concept data supporting development as: • Treatments (e.g. biologics, small molecules, cell therapies) • Diagnostics, platforms and research tools (e.g. biomaterials, scaffolds, therapeutic targets, cell expansion methods) • Devices (e.g. drug delivery, implants, restoration)

INNOVATION NEWS PEDIATRIC INNOVATION CHALLENGE On Tuesday, February 19, 2019, donations through the Children's Hospital Colorado Children's Hospital Colorado's Center Foundation, CU Innovations, and Chancelor Don for Innovation hosted their inaugural Elliman. At the end of the last presentation, the Pediatric Innovation Challenge. excitement in the air was tangible while the crowd Team members, local entrepreneurs, awaited the results. CU faculty members, Children's Foundation representatives, and donors came to support the As the judges deliberated, Michelle Lucero, Chief finalists and learn about their innovations. Four Administrative Officer and General Counsel, shared contestants presented revolutionary solutions to news of a last-minute donation from an anonymous some of healthcare's most challenging problems, donor who thought all four ideas deserved funding. all competing for their share of $100,000 in prize Thanks to this extraordinary gift, an additional money to further their projects. $20,000 will be earmarked for Dr. Adam Green's design. The Center for Innovation called for submissions last Leaders in innovation August and received many outstanding entries from across Children's Hospital Colorado. An external In a word, the event could be described as inspiring. committee identified nine semi-finalists. Four finalists Team members took the problems they face in the advanced to the main event, competing head- clinical setting and engineered creative, practical to-head in two categories: Prototype Stage and solutions that will absolutely change lives. Children's Idea Stage. After each contestant presented their Colorado, as an organization, prides itself on projects and fielded questions, the winners were promoting a culture of innovation, where bright determined by a panel of four judges with extensive ideas are developed and nurtured, where curiosity expertise in the healthcare innovation field. and questioning are valued. The Foundation, and donors, step up Contact the Center for Innovation: All of the $100,000 in prize money for the Pediatric Brett Peterson | [email protected] Innovation Challenge was provided by generous 11 CU INNOVATIONS | UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

PROTOTYPE STAGE Steven Moulton, MD Max Mitchell, MD Grand Prize Winner Fan Favorite Winner Seasoned entrepreneur Steven Moulton, MD took Max Mitchell, MD, a man who has been described as home the grand prize of $40,000 in the prototype \"all things heart\" won the fan favorite category for his category with his novel reusseable securement new invention, which could drastically improve surgical method for gastrostomy buttons. His new product, the outcomes for kids who need Ventricular Assist Devices \"Button Huggie,\" has the potential to save families and (VADs). Dr. Michell’s device automates the connection caregivers significant amounts of time and money while of an LVAD vascular graft to the aorta. The Colorado maintaining gastrostomy tubes. native and Army Reserve veteran recieved $20,000 in funding IDEA STAGE Juliette Hawa, PT, DPT Adam Green, MD Grand Prize Winner The grand prize winner in the Idea Phase category, Adam Green, MD, a pediatric neuro-oncologist in our Juliette Hawa, PT, DPT, shared her vision for a Center for Cancer and Blood Disorders shared an idea biofeedback app that would vastly improve the with applications that extend far beyond his field. His TeleRehabilitation experience in urology and concept for smarter nasogastric and orogastric tubes gastrointestinal medicine. Hawa proposes an are designed to deliver intact pills to the stomach, application-based update to the existing 12-year-old allowing critical medicines to be administered to rehab equipment which would allow patients and their patients with trouble swallowing. Whether they have families to download an app, procure basic hardware, a developmental disorder or are simply too young to do rehab exercises at home and record data for swallow, Dr. Green's devices represent a significant providers. Cleverly disguised as a game, the app has breakthrough in patient access. the potential to increase patient participation in rehab exercises, which would reduce remission rates for Spring / Summer 2019 12 certain conditions while saving families multiple trips to the clinic.

INNOVATION NEWS VIRTUAL REALITY F OR BEHAV I OR A L H E A LT H THE NATIONAL MENTAL HEALTH INNOVATION CENTER LEADS THE WAY WITH TECH AND PROVIDER PARTNERSHIPS BY FRANCIS GREENLEAF 13 CU INNOVATIONS | UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

oo often, conversations VR for employee wellness. People we can work with Alaska and solve about virtual reality (VR) who provide mental health care some of the problems here, we can tend to focus on its role in services need to be taken care of solve them anywhere.” The Center is the future of entertainment, as well, and VR mindfulness offers currently pursuing partnerships with the opportunity for a quick, relaxing other state and federal correctional Tsuch as games, 360 break. Using the technology also facilities nationwide. helps providers increase their degree video, or even major familiarity before offering it to Anschutz Medical Campus motion pictures like 'Ready Player patients. The Center has helped to advance One\". While VR has the potential the adoption of VR in a variety to transform the entertainment Substance Abuse Recovery of ways. They helped the School industry, can it be used as a tool for of Dental Medicine plan a VR healthcare? An on-campus partner A partnership between the Center ecosystem to teach human anatomy with CU Innovations, The National and Mind Springs Health offers and dental procedures. The Center Mental Health Innovation Center VR meditation as part of their works with Janet Corral on the (NMHIC) believes the answer to be a rehabilitation toolkit. Patients use Campus VR Committee, a group that resounding yes. TRIPP, a virtual reality system that is developing a campus-wide VR promotes calmness by placing infrastructure for students and faculty. Walter Greenleaf, PhD, is a senior the user in a relaxing environment technology strategist at the National combined with binaural audio and The Center also collaborates on Mental Health Innovation Center, encourages relaxed breathing. the development of student VR and one of the pioneers in the programs. Brian Kelly, a studenzt development of VR applications Inmate Mental Health in the Modern Human Anatomy aimed at addressing behavioral program, used the Center’s VR health. Greenleaf explains that, The Alaska Department of infrastructure to build a VR module “we know from decades of clinical Corrections is working with NMHIC designed to help Physical Therapy research that VR technology can on two projects. The first employs VR students increase their movement provide breakthrough solutions to help inmates meditate effectively, analysis skills, which can be far more that address the most difficult with a goal of reducing aggression. effective than actor-based training. problems in healthcare – ranging VR transports them from the confines “When physical therapy students from mood disorders such as of prison to a beach, a rainforest, or practice with actors, it’s difficult for Anxiety and Depression to PTSD, the moon. In these environments, the actors to accurately convey Addictions, Autism, Cognitive Aging, they are guided through meditation muscle and nervous deficiencies.” Stroke Recovery and Physical and relaxation techniques that they By creating a simulation that Rehabilitation.” The team at the report has a positive effect on their betterrepresents these physical NMHIC has a number of partnerships mental wellbeing and prepares symptoms, Mr. Kelly’s module is one with tech companies, healthcare inmates for environments outside of among many of the exciting new providers, and other organizations prison. ideas becoming a reality at NMHIC that are implementing these and the Anschutz Campus. solutions in Colorado and across the Another one of the Center’s partners, country. New York City based NSENA, Virtual reality has the potential to develops VR training platforms for radically impact mental health and Mindfulness inmates nearing the end of their wellness, and the Anschutz Medical sentences. They can practice: job Campus is positioning itself to be One of the most accessible, interviews, de-escalating potentially a national leader in realizing that broadly applicable, and effective violent conflicts, or handling tough potential. By fostering partnerships forms of behavioral health in VR is conversations with a boss or on campus, statewide, and nationally, mindfulness or meditation training. customer. the Center is accelerating the Users can put on a headset and adoption of new strategies to take select from a broad range of These simulations are designed to on the myriad challenges in modern environments designed to promote help them prepare for life on the mental health care. relaxation: a mountain top, a beautiful outside, and ultimately reduce the forest, or just about anything you emotional stress of this transition and To learn more about NMHIC visit: can imagine. Users can practice the possibility of recidivism rates, http://mentalhealthinnovation.org controlling their breathing, calming which are over 70% in Alaska. Citing their mind, and ultimately reducing geographic isolation and workforce Spring / Summer 2019 14 their stress. Often, the first step in a shortages in an interview for the partnership with the Center involves Anchorage Daily News, the Center’s the introduction of mindfulness Executive Director Matt Vogl said “If

INNOVATION NEWS RICHARD FOSTER, PhD ENTREPRENEUR IN RESIDENCE Richard Foster joins CU Innovations as the newest Entrepreneur in Residence (EIR). Dr. Foster’s experience will guide the development of ideas from CU academic entrepreneurs. Dr. Foster is a Venture Partner with Lux Capital. He is also the Managing Partner of the Millbrook Management Group LLC. Recently, he started a new machine learning company, General Semantics, which is focused on automated text analysis of public and private companies worldwide. Prior to forming Millbrook, he was with McKinsey & Company for 30 years, where he is an Emeritus Director and served as a Senior Partner and Director for 22 years. Dr. Foster co-founded the firm’s technology, chemicals, healthcare and private equity practices. He also led McKinsey’s worldwide knowledge development and served over fifty leading global companies primarily in healthcare, electronics, and chemicals as well as a number of nonprofit institutions. Dr. Foster has published two best-selling books: 'Innovation: The Attacker’s Advantage\" and \"Creative Destruction\". Richard Foster is a member of the American Academy of Arts and Sciences. He earned his B.S., M.S., and Ph.D. from Yale University in Engineering and Applied Science. 15 CU INNOVATIONS | UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

INNOVATION NEWS INNOVATION UPDATE UCHealth’s CARE Innovation Center is a immediately intervene and alert the ICU doctors close partner with CU Innovations, with and staff needed for patient care. Increased a shared goal of redefining the future accuracy in reporting and decreased response of health care. The center is partnering times have shown the effectiveness of the system with industry and startups in four main and improved patient outcomes. The next challenge areas: data science + artificial intelligence (AI), digital is to bring this kind of service and technology into patient experience, virtual reality (VR) + augmented the patient’s home. According to Dr. Zane, in-home reality (AR), and wearables + virtual health. devices have to prove their reliability, possess high accuracy and high connectivity all while being \"Health care needs to be fundamentally disrupted. HIPAA compliant. Bringing the level of care received We should embrace this disruption and drive by inpatients to the home will be the future of health change to improve care for our patients and the care. next generation,\" said Richard Zane, MD, UCHealth Chief Innovation Officer and Chair of Emergency To increase efficiency and accuracy of prescribing Medicine which is part of the CU School of medications, UCHealth has implemented a Medicine. UCHealth embodies this mantra through prescription decision support system. RxRevu a convergence of digital technologies with health partnered with UCHealth to launch SwiftRX, care to improve patient care, increase efficiencies, which presents the prescriber with medication and lower medical costs. Recent stories featured in recommendations automatically when a diagnosis national media share the role that UCHealth plays in is entered in the electronic health record. \"SwiftRx transforming the future of medicine. functions by analyzing key data points from the patient's medical record within the electronic health Monitoring multiple patients and providing record and recommends pharmacotherapy based immediate aid are challenges faced by every on the provider's impression or diagnosis,\" said Dr. hospital. Technology deployed at UCHealth’s Zane. Virtual Health Center allows ICU-trained nurses Technology integrates into the operating room (OR) to continuously monitor multiple patients with UCHealth’s partnership with LeanTaaS and simultaneously from a centralized adoption of iQueue, a program that uses AI and control room, enhancing the care machine learning to identify unexpected bottlenecks provided by the bedside care by examining how surgeons use their time in the team. When an issue OR. “iQueue can tell us, here are the three surgeons arises, the virtual who are maximizing the use of their OR time, and tools enable here are the three surgeons who aren’t using their nurses to OR time. Then, we’re able to schedule intelligently and maximize capacity,” says Steve Hess, Chief Information Officer for UCHealth. The CARE Innovation Center at UCHealth, located on the University of Colorado Anschutz Medical Campus, offers a comprehensive suite of resources and services designed to revolutionize health care with leading industry and start-up partners. Spring / Summer 2019 16

INNOVATION SPOTLIGHT CONGRATULATIONS 2019 FELLOWS SPARK Colorado has selected its second cohort comprised of 15 faculty working to develop drugs, medical devices, and diagnostic tools. This year's funding for SPARK projects comes from the State of Colorado, Advanced Industries Accelerator program as well as CU Anschutz funds. Outside industry experts selected technologies on the campus that will make a tremendous impact on patients’ lives. Selected projects are paired with industry mentors to guide the faculty on a commercialization strategy and pathway for the next two years. Andrew Monte, MD Josh Seinfeld, MD Juan-Pablo Idrovo, MD DIAGNOSTIC MEDICAL DEVICE MEDICAL DEVICE Associate Professor Associate Professor Associate Professor Project: A functional assay for Project: ESCAPE (External Project: VasaFast - synthetic cannabinoid detection Stereotactic Cranial Access Port Central arteries Karin Payne, PhD  for Evacuation) and vein access tool Marsha Guess, MD Steve Moulton, MD MEDICAL DEVICE MEDICAL DEVICE MEDICAL DEVICE Associate Professor Associate Professor Professor Project: Bioresorbable 3-d printed Project: Novel drug delivery Project: The Button Huggie - personalized implant for cartilage system to eradicate recurrent regeneration in pediatric growth Securement method for urinary tract infection gastrostomy buttons plate injuries 17 CU INNOVATIONS | UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

Dan LaBarbera, PhD Heide Ford, PhD Kunhua Song, PhD PHARMACEUTICAL PHARMACEUTICAL PHARMACEUTICAL Associate Professor Professor Assistant Professor Project: Drugs that reverse Project: Targeting the six1-eya Project: Heart regeneration by epithelial-mesenchymal transition for complex to inhibit metastasis conversion of non-myocytes into the treatment of metastatic cancers functional cardiomyocytes Mike Verneris, MD Mingxia Huang, PhD Phil Reigan, PhD PHARMACEUTICAL PHARMACEUTICAL PHARMACEUTICAL Professor Assistant Professor Associate Professor Project: Generation of engraftable Project: Therapeutically targeting Project: Targeting AMPK in of CtBP-mediated transcription in hematopoietic stem cells from glioblastoma induced pluripotent stem cells traumatic brain injury Ulli Bayer, PhD Robert Hodges, PhD Tim McKinsey, PhD PHARMACEUTICAL PHARMACEUTICAL PHARMACEUTICAL Professor Professor Professor Project: Development of Project: Targeting myofibrillar Project: Strategic, regulatory, antimicrobial peptides to treat financial and organizational gram-negative infections deacetylases to treat heart planning for IND enabling studies failure Learn more about SPARK: 18 http://sparkcu.org Spring / Summer 2019

EDUCATION AND OUTREACH WOMEN IN INNOVATION SPEAKER SERIES CELEBRATING SUCCESSES OF WOMEN IN INNOVATION AND LEADERSHIP BY CIGDEM H. BENAM, PHD CU Innovations has started a national reputation as a dynamic academia, to large pharmaceutical a new speaker series, leader who has led companies industry. \"Women in Innovation\", through various stages of growth. This series is hosted by In her role, she engages industry The third speaker of the series the Executive Director, stakeholders, from innovative and was Leslie Leinwand, PhD, Kimberly Muller, Esq. The goal earlier-stage companies to Fortune CSO of Biofrontiers Institute, of the series is to highlight and 500 leaders, to understand the Professor of Molecular, Cellular celebrate the success of women market forces driving disruption and and Developmental Biology and innovators and entrepreneurs, but the potential for continued innovation serial entrepreneur. Dr. Leinwand more importantly, create a venue in healthcare. Prior to joining the co-founded Myogen, to develop for aspiring women to learn from firm, Ms. Owens served as CEO of therapeutics for cardiac diseases, these examples and network with OptumHealth. Under her leadership, which was acquired by Gilead for each other. Gender disparity persists OptumHealth became one of the $2.5 billion. During her talk, enriched in STEM, healthcare and venture nation’s largest and most respected by personal stories, she emphasized capital. Three areas where women health and well-being companies. the need for self-confidence in are chronically underrepresented in breaking the glass ceiling as well leadership positions. The second speaker was Shelia as the importance of resilience and Violette, PhD, who is the Chief perseverance. Since its inception, the series Scientific Officer of Admirx, a CU has hosted three accomplished faculty founded startup. Admirx A common thread among all speakers. The first was the President raised capital from one of the speakers was the necessity of hard of Triple Tree Holdings, Dawn leading venture capital firms,and Dr. work and ability to take calculated Owens. Ms. Owens has diverse Violette, who was an Entrepreneur risk. responsibilities across Triple Tree in Residence with Atlas Ventures Capital Partners' principal investing joined the company following the Find out about future and its investment banking services. investment. Dr. Violette, an expert on CU Innovations Events visit: She has more than 25 years of large molecule drug development, http://innovations.ucdenver.edu healthcare experience, including has a career spanning from 19 CU INNOVATIONS | UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

CU INNOVATIONS TEAM IP LAW UPDATES BY JAMES PARRETT, ESQ. Did you know that CU Innovations filed 113 patents in 2019 on 51 different technologies? Intellectual property (IP) is the life blood of commercialization. Strong intellectual property incentivizes external partners to invest in CU technologies, helping to take them from campus to the patient. CU Innovations closely watches for any new developments in intellectual property law to ensure our investigators have expert advice to protect their discoveries. This section provides a short summary on recent changes to IP law. Consult with us to see how these changes may affect your inventions. The United States Supreme Court has been active in the 2018/2019 term deciding several IP-related cases, with several more on the horizon. Helsinn Healthcare S.A. v. Teva Pharms. USA, Inc. (No. 17-1229) - the Supreme Court determined that a confidential sale of an invention prior to filing a patent constitutes putting the invention “on sale,” which bars patenting under the America Invents Act. Rimini Street, Inc. v. Oracle USA, Inc. (No. 17-1625) - the Supreme Court clarified that recovery of litigation costs under the Copyright Act was limited to the six enumerated categories in the federal litigation statute, 28 U.S.C. §§1821 and 1921, specifically excluding expert witness and e-discovery fees. Fourth Estate Public Benefit Corp. v. Wall-Street.Com, LLC (No. 17-571) - the Supreme Court held that the Copyright Office must issue registration of the copyright before the owner may bring suit for infringement, but following registration the owner may sue for infringement occurring before and after registration. This may be significant given the backlog of registrations pending at the Copyright Office. Cases to watch for 2019 Return Mail Inc. v. U.S. Postal Service (No. 17-1594) - the Supreme Court heard argument on February 19 concerning whether the U.S. government may be considered a “person” under the America Invents Act for purposes of post-grant review. Hikma Pharms. USA Inc. v. Vanda Pharms. Inc. (No. 18-817) - the Supreme Court is considering granting certiorari for this case involving whether diagnostic methods constitute patentable subject matter post Alice and Mayo. Recently, the Court invited the Solicitor General to file a brief on this issue. This presents an opportunity to clarify what constitutes a patentable invention, an issue that has been contentious for several years. About James Parrett James joined the Licensing Group of CU Innovations in January 2018. As the Manager of Pharmaceutical Development and Intellectual Property, he works closely with research scientists helping transition their creations from the laboratory to the public. His legal practice focuses on the acquisition and development of intellectual property, including the filing and prosecution of patents, as well as the negotiation and licensing of patented inventions. James actively engages with campus investigators advising on how to commercialize and develop novel medications and formulations discovered at the Anschutz Medical Campus. He is a graduate of William and Mary School of Law and the University of Mississippi School of Pharmacy. Spring / Summer 2019 20

RESOURCES FUNDING OPPORTUNITIES CDIFUND The Chancellor’s Discovery Innovation Fund is a $5M fund that will provide CHANCELLOR’S DISCOVERY INNOVATION FUND tranched milestone-based grants aimed at advancing the most promising CU ANSCHUTZ MEDICAL CAMPUS therapeutics, devices, and healthcare innovations. STARTUP TOOLBOX Learn More>>> https://cdifund.secure-platform.com The SPARK program focuses on technologies addressing unmet medical needs to bridge the “translational gap” between the lab bench and the patient. Call for applications opens the final quarter 2019. Learn more>>> https://sparkcu.org The Gates Grubstake Fund focuses on accelerating basic, clinical, and translational research related to the field of regenerative medicine. Call for applications will be announced June 2019. Learn more >>> https://bit.ly/2Pmas7t Startup Toolbox is a novel platform designed to provide faculty with services and resources related to commercialization not supported by traditional funding opportunities. Grants are awarded on a rolling basis. Learn more>>> https://bit.ly/2OsSScN For more information on funding opportunities: http://bit.ly/CUInnovationsFunding UPCOMING EVENTS I-Corps@CCTSI MILLION DOLLAR REAGENTS Training Program Commercializing Research Spring 2019 Program Tools to Generate Funding May 3, 2019 June 3, 2019 STARTUP LAW SEMINAR SERIES SBIR/STTR How To License A Technology From A University Training May 14, 2019 June 6 SPARK SEMINAR SPARK 2019 Medical Device Entrepreneurship Kickoff May 15, 2019 June 2019 SPARK SEMINAR Manufacturing Considerations May 29, 2019 21 CU INNOVATIONS | UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

Rendering of the new Anschutz Health Sciences Building Learn more about CU Innovations: http://innovations.ucdenver.edu Contact us: (303) 724 - 3720 [email protected] Follow us: Twitter - @cuinnovations LinkedIn - http://bit.ly/LinkedInCUI Read and share the digital copy of this newsletter: http://bit.ly/newsletter2019ss Spring / Summer 2019 22

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