Most Promising Digital Health Solution Providers in 2022

WWW.THEENTERPRISEWORLD.COM | AMERICA EDITION | MAY 2022 Most Promising DIGITAL HEALTH SOLUTION Providers in 2022 Avik Pal, CEO Unified Platform for Hybrid & Decentralized Clinical Trials







From Editor’s Desk Digital health has a broad scope that include some categories like mobile health, health information technology, wearable devices, telehealth and telemedicine and so much more. These technologies use some of the best computing platforms, software and sensors for health care and other related uses. With the evolution of digital health, it has helped advances in the healthcare to provide people with some of the best care at their disposal. Featuring for The Enterprise World's this issue of Most Promising Digital Health Solution Providers in 2022 are the stories of some such companies that are helping to advance digital health with their innovative solutions. For the cover story read- CliniOps is a Technology and Data Science company for the Life Science Industry. The company helps Pharma and Biotech companies to conduct Clinical Trials (Hybrid & DCT trials) that makes drug trials accessible, inclusive, faster, and cheaper. The technology platform leverages AI, Mobile, Analytics, Cloud, Sensors and Connected Devices. CliniOps Unified Technology platform offers seamless trial conduct across site-visit, tele-visit, home-visit, lab-visit and more, including data collection from wearables and connected devices. The company also offers comprehensive data services to augment the in-house team, of the sponsors and CROs, throughout study start-up, study conduct and study closeout phases. CliniOps offers a comprehensive study setup service. Their customized services are designed to help you configure your trials more efficiently. The platform will not only complement your internal team to achieve your goals but will also ensure transparency and collaboration throughout the duration of your trial. Statum Systems is a healthcare technology start-up founded by healthcare professionals in the Boston medical community. Concerned about the fragmented state of medical communication systems in hospitals and medical centres, and especially with the continued use of traditional pagers and other single purpose applications and devices that require care team members to constantly juggle from one system to another. To address the issue, Statum Systems created a unified medical communications & collaboration (UCC) platform, StatumHEALTHtm, that simplifies workflows for care team members with a focus on improved patient care. In an interview with The Enterprise World- Hyprevention was founded in France in 2010, to develop innovative implantable medical devices for the orthopaedic surgery in order to address bone fragility. The idea of bone reinforcement came from Orthopaedic Surgeons. Seeing more and more elderly people coming to their hospitals for hip fracture treatments and any osteoporotic fractures due to aging and growing population, they think on developing unique solutions. After studying the market opportunity and project feasibility, the surgeons and I have created the company together. USHC was founded in 2003 by myself and Dr. Raymond Gavery, MD. While I was pioneering self funding and onsite healthcare and leveraging IT in the industrial arena, Dr. Gavery was pioneering onsite and near site clinics and predictive health. Our unique combination of the same principles from different angles made for a highly productive approach. Within a few short months we launched one the first online health portals in 2003, our Personal Health Dashboard. The PHD combines DNA, biometrics, medical and Rx claims, demographic, wearable, lifestyle and payroll data in our Health Risk Assessment, which when added to lifestyle data is the predictive model for the member. Shalmali Shalmali W.

The Enterprise World, 1985, Henderson Rd, Columbus, Ohio, 43220 Follow Us On: For Editorial Concerns: [email protected] For Sales & Branding Enquiries: [email protected] For Subscription: [email protected] Publisher The Enterprise World Creative Content Editor Shalmali W. | Adeeb Marketing Coordinator Peter J. PR & Marketing Coordinator James H. Business Development Executive Jessica S. Creative Design Head: Sushant K. Social Media Manager Narendra S. Digital Circulation Manager Amanda V. This list is NOT a ranking. The companies on listed in magazine serve different aspects of the market, making ranking them in any order except revenue impossible and unfair. We try to bring a perfect platform for business organization to showcase their valued products/ services. Copyrights © The Enterprise World | 2019. All Rights Reserved. The images and content included in this magazine should not be copied, transferred or reproduced in any form or by any means, electronics, mechanical, photocopying, recording, otherwise, without proper permission from The Enterprise World. The Enterprise World solely owns all the reprint rights.

Leaders in Spotlight For the cover story read- To address the issue, Statum Systems created a unified medical communications & collaboration (UCC) CliniOps is a Technology and Data Science company platform, StatumHEALTHtm, that simplifies for the Life Science Industry. The company helps workflows for care team members with a focus on Pharma and Biotech companies to conduct Clinical improved patient care. Trials (Hybrid & DCT trials) that makes drug trials accessible, inclusive, faster, and cheaper. The In an interview with The Enterprise World- technology platform leverages AI, Mobile, Analytics, Cloud, Sensors and Connected Devices. CliniOps Hyprevention was founded in France in 2010, to Unified Technology platform offers seamless trial develop innovative implantable medical devices for conduct across site-visit, tele-visit, home-visit, lab- the orthopaedic surgery in order to address bone visit and more, including data collection from fragility. The idea of bone reinforcement came from wearables and connected devices. Orthopaedic Surgeons. Seeing more and more elderly people coming to their hospitals for hip fracture The company also offers comprehensive data services treatments and any osteoporotic fractures due to aging to augment the in-house team, of the sponsors and and growing population, they think on developing CROs, throughout study start-up, study conduct and unique solutions. After studying the market study closeout phases. CliniOps offers a opportunity and project feasibility, the surgeons and I comprehensive study setup service. Their customized have created the company together. services are designed to help you configure your trials more efficiently. The platform will not only USHC was founded in 2003 by myself and Dr. complement your internal team to achieve your goals Raymond Gavery, MD. While I was pioneering self but will also ensure transparency and collaboration funding and onsite healthcare and leveraging IT in the throughout the duration of your trial. industrial arena, Dr. Gavery was pioneering onsite and near site clinics and predictive health. Our unique Statum Systems is a healthcare technology start-up combination of the same principles from different founded by healthcare professionals in the Boston angles made for a highly productive approach. Within medical community. Concerned about the fragmented a few short months we launched one the first online state of medical communication systems in hospitals health portals in 2003, our Personal Health and medical centres, and especially with the Dashboard. The PHD combines DNA, biometrics, continued use of traditional pagers and other single medical and Rx claims, demographic, wearable, purpose applications and devices that require care lifestyle and payroll data in our Health Risk team members to constantly juggle from one system Assessment, which when added to lifestyle data is the to another. predictive model for the member.

10. CliniOps

22. CONTENTS Hyprevention 32. Statum Systems 42. US HealthCenter 26. The 5 Most Important Questions To Ask Your Dental Implant Provider! 38. Considering Your Medical Career Options?

Unified Platform for Hybrid & Decentralized Clinical Trials Mr. Avik Pal, CEO 10 M A Y 2 0 2 2

COVER STORY www.theenterpriseworld.com 11

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Cecile Vienney, CEO 22 M A Y 2 0 2 2

Addressing Medical Needs with Innovation Innovation in the field of medical devices feasibility, the surgeons and I have created the wasn't a much anticipated one but all the more company together. necessary. The traditional devices just could not cope with the rising and different needs of the What were the initial challenges you faced? patients. And especially so regarding orthopaedics. One is a scenario where with Robotic Surgeries, As new born star-up company, the initial challenge doctors have been able to cure patients quickly and for us was to raise more money than our own efficiently, it needed a strong support of medical investment to support our first product development devices to make the revolution happen. up to commercialization. Therefore, we met business angels across Europe to convince them on our Featuring for The Enterprise World's this issue of revolutionary and unique technology. Our financing Most Promising Digital Health Solution Providers partners are doctors and entrepreneurs. They in 2022 is Hyprevention, a company focused on understand our business in medical devices and the addressing medical needs with innovation. challenges linked to entrepreneurship. They are very supportive since the time they join the founders In this interview with Cecile Vienney, CEO, let us 'team. know more about the journey of the company. Which was that point that triggered the growth of Tell us about the company. the company? Hyprevention was founded in France in 2010, to Today, it's clearly the 510(k) clearance that we have develop innovative implantable medical devices received in March 2020 that gives us the best for the orthopaedic surgery in order to address opportunity to growth our company and business. bone fragility. The idea of bone reinforcement came from Orthopaedic Surgeons. Seeing more After few years exploring the EU market, the new and more elderly people coming to their hospitals EU regulation limiting drastically the introduction for hip fracture treatments and any osteoporotic and even the maintenance for innovative products fractures due to aging and growing population, like ours, we put all our energy and resources to they think on developing unique solutions. After enter the US market and deliver quality products. studying the market opportunity and project www.theenterpriseworld.com 23

What are the key What are the products/services the company achievements of your focuses on? How are your services different entrepreneurial journey? from those in the market? As you says, it's a journey. Our today focus is the US launch of our device V- Almost, every day is an STRUT© Vertebral Implant. The V-STRUT© achievement. My role and proposes an unique solution on the market, with a pedicle anchorage that is going to significantly my skills become stronger improve the clinical performance for vertebral and stronger. over the time. fracture treatment. Moreover, our device is very That is my real achievement simple to use and reduces the per-operative to serve the company I have complications. Finally, as already said, we have a reasonable pricing positioning, and a very good founded. margin, leading to a win-win-win situation. A win for the patient who will receive the best treatment 24 M A Y 2 0 2 2 for their pathology, a win for the payers with an affordable pricing and a win for Hyprevention with good margin. Our second focus is our historical product Y- STRUT® Hip Implant indicated to prevent hip fracture. We have initiated US-FDA-510(k) process and are looking forward to putting it on the market. How do you decide to take the company a step further in terms of your products/services? Our products are developed according to the clinical needs and market needs. The clinical need is identified by reviewing the scientific literature and by talking to surgeons who are expressing the gaps to be filled based on their daily activity at the hospital. Then, we make sure that these needs correspond to a large population, a sufficient market. That is why we have started by developing Y- STRUT® Hip Implant to prevent hip fracture. Hip fracture is a worldwide public health issue with the growing and aging population. Osteoporosis, leading to hip fracture, is a major burden for the society. Then, we have develop V-STRUT© Vertebral Implant to address an unmet clinical need in the field of vertebral fracture, meaning treat with long term efficacy the fracture (avoid refracture) and prevent adjacent fractures at the upper or lower level of the vertebra, as observed with the products on the market.

Is there any new addition to the list of products/services? Anything exciting you would like to share? Our technique is called the STRUTPLASTY. It is the combination of a polymer implant with bone cement. The PEEK polymer we use presents mechanical characteristics close to the normal bone. The STRUTPLASTY aims to reinforce the bone with an anatomical solution, avoiding extra stress. After Y-STRUT® for hip and V-STRUT© for vertebras, there are other bone location that will benefit in the STRUTPLASTY technique. What do you think are the responsibilities of an entrepreneur? In the case of medical device company like Hyprevention, the first responsibility of the entrepreneur is the patient, the customer. We develop quality products with a real clinical need to serve the patients. To do so, we need a strong team : shareholders, able to understand the need of investments prior, an operational team engaged in the product development, and a pool of supporting and skilled surgeons who contribute to the products development. The responsibility of the entrepreneur is to find the right people and any stage, in order to build the best strategy and proceed with the best execution. Can you please brief us about your professional experience? I am a Mechanical Engineer. After several years in different industries, I joined STRYKER Spine where I developed innovative medical devices as Global Program Manager during 10 years. Then, I became Chief Operational Officer at VEXIM, a French start-up, during 2 years. VEXIM was acquired recently by STRYKER Spine for more than $180M. After this tremendous experience, I founded Hyprevention, 10 years ago, to develop the fracture prevention market in hip. www.theenterpriseworld.com 25

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The 5 Most Important Questions To Ask Your Dental Implant Provider! A beautiful smile speaks louder than words, and that’s why dental implants are so important; they can provide attractive stability so that you can move through your day with confidence. Before you get your dental implant procedure, these are Important Questions To Ask Your Dental Implant Provider to ensure a safe surgery with lifelong success. 1. What Kind of Formal Education in Dental Implantology Does your Dental Provider Have? Knowing more about your dental provider’s training and education is an important part of selecting a dental professional. Ask them how long they spent in training and what kind of continuing education they’ve received, recommends Dr. Amanda Sheehan of Oakland Family Dental in Waterford, Michigan. She is a diplomate in the International Congress of Oral Implantology, which is one of the only board certification programs in the U.S., and she has completed more than 2,000 hours of continuing education that includes dental implants. If you’re concerned that your dental provider doesn’t have extensive education and training, Dr. Sheehan advises that this is not the time to be shy. “Ask them what kind of guarantee they offer, how many of these implants have they done before, and what’s their success rate. You need to make sure that you have confidence in your provider,” she says. 2. Does your Dentist have a CBCT Scan in their Office? While the term CBCT or cone-beam computed tomography may be unfamiliar, this is just a 3-dimensional imaging machine that allows the dental provider to get a more detailed look at all of the features of your mouth. A typical X-ray offers a 2-dimensional look that www.theenterpriseworld.com 27

highlights bone structures but a 3-D image 4. How is your Dentist going to take into Account includes the thickness of your jaw bone and the your Specific Medical Conditions? location of your nerves, artery, and more. In Dr. Sheehan’s experience, the success of your Dr. Sheehan says this advanced view is necessary dental implant procedure rests heavily on your for dental implant work because it allows the personal medical history and conditions. In Dr. dental provider to have a better road map for the Sheehan’s practice, she may work with a patient’s procedure, identify areas of greater risk, and primary care physician if the patient has low appropriately plan to reduce those risks. “We Vitamin D levels; achieving optimal Vitamin D have a CBCT right here in the office and I use it levels can improve the outcomes of dental every day to make sure that my patients are safe. implant surgery. Being a smoker is a common health concern that can affect the success of I would never place an implant on somebody dental implant surgery and healing, too. When without one, and I would never let somebody in talking to your dental surgeon, be sure to inform my family have one without one. It’s just too them of your full medical history and any risky. The technology is here to help us make this medications you’re taking so your treatment plans very easy for you,” Dr. Sheehan says. can be customized to your personal needs. 3. Will the Dental Implant and the Crown be 5. How Accessible is your Surgeon after Surgery? Placed in the Same Office? Being able to contact your dental implant surgeon In some cases, getting dental implants requires after your procedure is critical. If you have a the work of two doctors. There’s the oral surgeon question about healing, a suture comes loose, or who places the implant, and a dentist who puts on you’re wondering whether you can eat a the crown. There’s nothing wrong with this particular food, you’ll want the comfort and arrangement as long as those doctors work reassurance of being able to talk to your doctor. If closely together to ensure you have great results you have to travel a long distance for care, as with your dental implants. Doing things this way happens when people choose to have implant can take a little more time and add a little more surgery internationally, you may not be able to expense because there are two doctors involved in return to your doctor’s office easily if there’s a the process, but some oral surgeons and dentists concern. Dr. Sheehan reminds patients that make great teams and have worked in having a surgeon who communicates well helps collaboration for the benefit of their patients for ensure a great dental implant experience. years. Keep these questions in mind when evaluating Dr. Sheehan suggests finding a team with a oral surgeons to increase your chances of positive proven track record of success in placing dental outcomes with dental implants. Everyone wants a implants or finding a single dental care provider beautiful smile with secure and healthy teeth. who can complete both the implant and crown Qualified dental professionals will be happy to procedures. answer these and any other questions you may have about the dental procedures best suited for your oral health goals. 28 M A Y 2 0 2 2







Fred Lizza, CEO 32 M A Y 2 0 2 2

Enabling Excellent Medical Communication Challenges in systemized medical communication This device, StatumCONNECTtm, eliminates traditional have been mounting for years, and there have been pagers without losing the reach and reliability of pager- very few companies identifying the problem and frequency messages. brainstorming a solution that fits. Fred Lizza, and the team of Statum Solutions have been among the few who have StatumHEALTH also collects comprehensive data found the perfect way to end this significant problem regarding medical communications, and analysing it to plaguing healthcare. identify opportunities for workflow, patientcare, and financial performance improvements. This data-driven Featuring for The Enterprise World's this issue of Most component of our solution will grow in importance as Promising Digital Health Solution Providers in 2022 is StatumHEALTH collects more data and applies AI-based Statum Systems, a company that is enabling excellent tools and predictive analytics to the data in future releases. medical communication. Overcoming the Challenges- The Company- “Statum is poised to explode in 2022 as we move from beta Statum Systems is a healthcare technology start-up founded testing to commercial release of StatumHEALTH.” by healthcare professionals in the Boston medical community. Concerned about the fragmented state of Statum's initial market response has been overwhelming. medical communication systems in hospitals and medical Every physician, surgeon or medical professional who sees centres, and especially with the continued use of traditional their solution wants it. This is because, for the past two pagers and other single purpose applications and devices decades, hospitals have accumulated many special-purpose that require care team members to constantly juggle from and single purpose communications systems. They don't one system to another. interface with each other, only address one or two aspects of providing patient care and require care team members to To address the issue, Statum created a unified medical jump from one system to another. communications & collaboration (UCC) platform, StatumHEALTHtm, that simplifies workflows for care team Statum's leadership team is the perfect blend of medical members with a focus on improved patient care. Statum professionals and technology executives. Several co- also invented an optional device in the form of an ID badge founders have deep medical experience while our CEO, holder that captures pager signals and sends them via SVP of Corporate Development and Advisory Board Bluetooth to StatumHEALTH on the user's smartphone. members bring many years of success in launching and growing technology-based enterprises. www.theenterpriseworld.com 33

The Products and As COVID has taxed hospital staff to the limit and Services- identified a clear need for medical centres to upgrade their IT infrastructure. The medical UCC platforms will StatumHEALTH's competitive advantage streamline care team workflows, reduce communication- comes from three distinct capabilities that the based errors and delays, turn beds faster and enforce above-listed competitors cannot match: HIPAA and security compliance. Like many other industries, medical communication infrastructure is Delivery of low- evolving from disparate point solutions to integrated frequency broadcast platforms. pager messages directly to the smartphone The Service Directory- A patient-centric Low-Frequency Pager Messages Directly To architecture Smartphone An enterprise scale Pager service providers broadcast their pager messages over unified medical low-frequency bandwidths, providing greater reach and messaging and coverage and higher reliability. That's why over 80% of US collaboration platform – hospitals still use pagers – so critical messages can be not a single purpose received immediately in all areas, even places like messaging system. radiology suites, where WiFi, 5G and cellular signals are not reliably available. Statum uses multiple communications modalities, including direct receipt of pager messages by StatumCONNECT, to ensure efficient message receipt while not losing reliability. “By using our patented technology, we maintain the reach and reliability advantages of low frequency pager messages, but deliver rich messages directly to the users' smartphone without store and forward delays.” Patient-centric Architecture Given that many of Statum's founders come from the clinical world, the team has built their architecture from the ground up to focus their communications around the patient. Their “patient sessions” function deliver a communications forum that allows for synchronous and asynchronous communications across care providers. Competitive solutions do not facilitate a patient-centric method of communications that allow for all the patient's care team members to have instant insight on patient interactions and data. Instead, competitors rely on standard peer-to-peer communications that lead to siloed communications, necessitating repetition for those not included. “Our patient session design enables all of a patient's care team members to share the same dialogue and be alerted to any changes or updates to the patient's condition.” By unifying communications around the Patient Sessions, Statum facilitates efficient communications and create a 34 M A Y 2 0 2 2

natural hub for communications data collection that provides insights never- before seen by hospital administrators/executives. Enterprise UCC Statum believes that after years of investing in limited, single purpose medical communications systems, the healthcare IT market is entering a cycle where these disparate systems will be gradually but consistently replaced by a unified medical communications and collaboration system. The move to UCC's will simplify learning and onboarding of team members, streamline workflows and improve communications – all resulting in better and more efficient patient care, faster bed turnover and few errors. This is consistent with cycles in other maturing markets, where single purpose systems were replaced by integrated suites and platforms. Fred Lizza- Leading the Way- “Anyone who has never made a mistake has never tried anything new” To say the least, Fred is a serial CEO. He has previously held the role of a CEO at six other software based- technology businesses. Fred is typically introduced to an organization through the investors/owners of a business, either early in its life cycle to launch and scale the business or at a later stage to re- position the company to better achieve its potential. Fred has led multiple companies to successful exits by acquisition and he has also grown a company and led it through its IPO and secondary public offerings. He has launched new products into the AI, ERP, eCommerce and supply chain markets. www.theenterpriseworld.com 35





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Considering Your Medical Career Options? The Aesthetics Industry Is Calling When you wish to hop on the medical industry, the good news is, there are so many career options from which you could choose. Careers aren’t only limited to the usual medical procedures in the hospital, if this isn’t what you’re after; there are other sectors within the medical field like in therapy, the academe, dentistry, and even the aesthetics industry. In America and in Canada in particular, the aesthetics industry is a booming one. So many more men and women across all ages and demographics are keen on having aesthetic procedures done. Some require surgery, while others are non-invasive. But even for the latter, medical expertise is still necessary to ensure top-notch results. If you’re still on the fence about it, this post should give you convincing reasons why you should consider entering the aesthetics industry. Read on! 1. High In Demand In Canada, cosmetic nurses are in high demand, much like in other places around the world. Technological advancements have also brought more treatment options across different budget ranges, which has made aesthetic treatments more accessible to many people. Aging is normal, but its effects can be slowed down through various procedures. This means men and women around the world are now more than willing to spend for aesthetic treatments, just to keep the largest organ in their bodies healthy. This demand presents a wide financial opportunity for clinics to open and medical aesthetics industry nurses and dermatologists to enter the aesthetics industry. As such, those willing to adapt to the current trend will have flourishing careers with competitive pay. www.theenterpriseworld.com 39

2. Have More Control Over Your Time 4. More Time To See More Patients In A Day Unlike other medical professionals working in a hospital Economically, you may also be able to see more patients in setting, working in medical aesthetics enables you to have a day. Depending on the procedure your patients have, more control over your time. Dermatology clinics usually some may even be as quick as half an hour, such as for follow regular business hours. However, if there are no Botox treatments. For as long as you don’t skimp on the patients or scheduled appointments for the day, they can opt quality of service just to see more patients in a day, you to open later, if they have something else to do. This means could potentially earn more when you admit more patients. it’d be easier for you to adjust your weekly or daily schedule according to your preferences and also your Schedule-wise, this also means you don’t necessarily patient load. always have to go beyond your clinic hours just to fit all your patients within the same working day. More so, the Most importantly, unlike other medical professionals, you bigger your clinic and the more staff you’ve hired, the neither operate on an on-call demand nor would you have to higher the number of visitors that can be catered to do graveyard shifts. This is definitely a major plus, simultaneously. especially for those who have familial obligations. Conclusion 3. Work In A Fulfilling Field As you can see, working in medical aesthetics is a very When you’re working in a career where you have a sense of attractive work opportunity. This is a great sector for those fulfillment, your working days are going to be filled with so who wish to work in healthcare but don’t necessarily like to much pride and joy. It’s a false notion to think that those be in the hospital. In Canada, the USA, and even in other who undergo medical aesthetic procedures are only in it for parts of the world, there are so many training opportunities vanity. Some may be suffering seriously from a lack of you can avail to receive the proper certifications necessary confidence and self-esteem due to their physical to be qualified in medical aesthetics. imperfections. For as long as this is a field you’re excited and keen on You can change their lives, even if it’s only through the job entering, you’ll find your workdays to be exciting. It’s that you do. You can make your patients feel a lot better fulfilling work too when you get to change the lives of your about themselves by giving them a newfound sense of patients by giving them newfound confidence to let their confidence. Furthermore, you get to witness your patients’ inner beauty shine. transformation, and you may even leave an impact on their lives, emotionally and psychologically, by simply being with them every step of the way. 40 M A Y 2 0 2 2



Mr. Gavin Quinnies, CEO 42 M A Y 2 0 2 2

A Complete Health Management Company For a long time now, every individual working in the for the member. healthcare has been struggling to help their patients get better. What could fasten the process is if the In 2015 the Intel GE Validation Institute 'validated professionals knew what the patients are at risk of PredictiMed's™ ability to identify and lower the predisease beforehand. This is nothing but the new developing high risk level, which may precipitate a higher use of ER technology of predictive analysis which is now being used and hospital services, in thirteen major disease categories to widely in healthcare. This has enabled many healthcare a lower level where the pre-emptive intervention can be institutions to help their patients in a better way. applied and thus reduce the incidence of ER visits and hospitalizations between 80 and 93%. Our evidenced based Featuring for The Enterprise World's this issue of Most science and PredictiMed™ technology suite, combined with Promising Digital Health Solution Providers in 2022 is US our Wholeistic™ Care navigation activates, educates, HealthCenter, a company providing this technology to help guides and incentivizes members to manages and improve it partners. health. In this interview with Mr. Gavin Quinnies, CEO, find out In 2019 USHC was third party validated at the highest level more about the journey of the company. for Care Navigation, and in 2020 for Population Health management, also at the Gold Level. Currently we are Tell us about the company. pursing having our financial predictive model third party validated. With over 100,000 active members in nearly all USHC was founded in 2003 by myself and Dr. Raymond US states, and 19 years of experience with 100% employee Gavery, MD. While I was pioneering self funding and retention, USHC has built one of the most deep and wide onsite healthcare and leveraging IT in the industrial arena, PHM platforms anywhere. Dr. Gavery was pioneering onsite and near site clinics and predictive health. Our unique combination of the same What were the initial challenges you faced? principles from different angles made for a highly productive approach. Within a few short months we The concept of disease prevention was new in 2003. Yes launched one the first online health portals in 2003, our there were pockets of it in areas such as fitness, nutrition Personal Health Dashboard. The PHD combines DNA, and so forth, but it has been an upstream battle. Today biometrics, medical and Rx claims, demographic, wearable, predictive medicine is still early, and USHC has over 20 lifestyle and payroll data in our Health Risk Assessment, years of experience in the game, yet we are still trying to which when added to lifestyle data is the predictive model change the paradigm. www.theenterpriseworld.com 43

Which was that point that triggered Our evidenced based science and PredictiMed™ the growth of the company? technology suite, combined with our Wholeistic™ Care navigation was third party validated at the highest level for We started using our predictive Care Navigation in 2019. modelling and engagement in the insurance industry, building self- Additionally, in 2020 USHC received the highest funded and voluntary benefit products recognition in our industry for by receiving the Gold Health with partners. This provided a better Value Award for Population Health management. platform to leverage our risk What are the products/services the company focuses on? management toolset and combine our How are your services different from those in the market? engagement systems. The PredictiMed™ predictive model The PredictiMed health management system comprises of a Personal Health Dashboard™ (PHD), health coach tracker, has been third party validated by corporate health profile, health counts, Sweeper™ medical Intel/GE Validation. In February of and pharmacy claims analytics tool, and content 2015, the Institute had the opportunity management system. to validate PredictiMed's™ ability to identify and lower the predisease The PHD is a dynamic and comprehensive user portal high-risk level, which may precipitate utilizing a responsive design that provides a seamless, personalized user experience. It incorporates an inclusive a higher use of ER and hospital health profile and medical history chart with periodic and services, in thirteen major disease episodic medical information that can be accessed at categories to a lower level where the anytime and anywhere. Being a safe, encrypted medical pre-emptive intervention can be site, the PHD has a medical passport with personal, medical applied and thus reduce the incidence and insurance information, as well as a comprehensive of ER visits and hospitalizations health and wellness management site. between 80 and 93%, depending on PredictiMed's Health Coach Tracker tool aids practitioners the disease category. in overseeing interactions with participants such as setting Lower back pain outcome was the goals, tracking appointments, collecting data on attained only disease category, which resulted and not attained goals as well as billing the payor for in a 17% reduction from the critical encounters. The tracker is also a data mining tool which risk level to a lower, less emergent uses filters to perform searches to a wide array of categories including participation, demographics, lifestyle categories, level. disease categories, predisease risk levels biometric test values, Wellcentive Score and many other parameters. This 44 M A Y 2 0 2 2 allows for targeted interventional strategies not available in any other platform. The administrative reporting dashboard provides a confidential executive summary report that is based on the analysis of health risks and behaviors. USHC provides not only the technology, but healthcare advocacy services such as prior authorization, large case management, disease management, predisease management, and lifestyle management benefit enrolment and benefit advocacy. This service line of Wholeistic™ Coaching is significantly different than the traditional multi specialist and siloed approach prevalent in the industry today. In 2004 USHC recognized this creates unhappy user and low engagement experiences and so created the Wholeistic™ Coaching approach.

The Company also was asked by a leading health science university to create a coaching certificate program for senior level students, and so a 5 credit course was created in 2010, which is now available online. Because of the use of this science, technology and advocacy approach, USHC is the only organization to be validated for Care Navigation. Validation Institute, an independent, objective, 3rd party organization focused on changing healthcare, validated US HealthCenter and its PredictiMed™ Population Health and Wellness Analytics, Predictive Modelling, Engagement and Care Solution to receive the highest award of recognition in the category of “Care Navigation.” Care Navigation is a sub-discipline of care coordination that aspires to steer patients to the most appropriate and effective clinical provider. According to the Institute, what put PredictiMed™ over the edge was validated analytics leading to pre- emptive interventions that can reduce the incidence of ER visits and hospitalizations between 80 and 93%. Can you please brief us about your professional experience? Trained in engineering and management systems, Mr. Quinnies started his career developing artificial intelligence, automated process planning, and intelligent networks in the aerospace industry. Afterward, he served as COO for a metals manufacturing and distribution firm, playing a key role in its successful growth from $20MM firm to $100MM with multi-state operations. During this time, Mr. Quinnies developed industry-leading health, safety, IT, quality, sales and productivity management systems. He implemented his first incentive-based wellness program in 1992 resulting in a 4:1 ROI. After a successful exit involving a multi-competitor roll up and NYSE IPO, he stayed on as Chief Quality, Safety and Health Officer for the $2.0 billion dollar parent company, managing 100 locations nationwide. Before co-founding US HealthCenter, Mr. Quinnies operated a consulting company for Quality, Safety, Health and Life Sciences. His largest client was IBM, helping automate the pharmaceutical industry's new drug approval process. www.theenterpriseworld.com 45