circRNA is abundant and conserved across species, and also exhibits tissue-specific and cell-specific properties. Importantly, circRNA is stably expressed in saliva, blood, and exosome, which makes it a promising biomarker for diagnosis, prognosis, and therapeutic response for cancer patients. Furthermore, several studies have indicated that circRNA exhibited a powerful potential in regulating proliferation, apoptosis, angiogenesis, and metastasis, suggesting that circRNA may be an important target molecule in cancer. Therefore, the discovery of disease related circRNA may provide a new perspective for the diagnosis and treatment of cancer.
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