2022 Hybrid annual Meeting Program

Lifecycle Approach: Coming Together to Make it Happen

Thank You to All Our Sponsors and Exhibitiors PLATINUM SPONSORS HEALTH ECONOMICS and HEALTH TECHNOLOGY ASSESSMENT DIAMOND SPONSORS GOLD SPONSORS EXHIBITORS

Contents 5 Introduction 6 8 President’s Welcome 9 Local Organizing Committee  11 Local Organizing Committee 12 International Scientific Program Committee (ISPC) 15 HTAi 2022 International Scientific Program Committee (ISPC)  17 About HTAi 18 Interest Groups 19 HTAi Policy Forums 20 Partnerships HTAi Secretariat 21 33 General Information Schedule-at-a-Glance 35 Program 45 Agenda 63 Feature Sessions 67 Workshops  75 Panels 87 Orals Posters 88 101 Poster Presentations  Poster Displays 105 HTAi and Associated Meetings 106 106 HTAi and Associated Meetings 107 HTAi Policy Forum Meetings and Sessions HTAi Interest Group Meetings 109 115 Symposia Sponsors /Exhibitors 116 118 Platinum Sponsors 120 Diamond Sponsors 121 Gold Sponsors Exhibitors

hoTaef kgailonthogdccaarree Our Mission: Taking care of good health care 1. care is effective for a reasonable price; Every person residing or working in the Netherlands is 2. care is decided on in collaboration between healthcare entitled to good care services from the basic health insurance package. The National Health Care Institute is a government professionals and patients; organization whose main task is to put together the basic 3. care is organized as close to the patient as possible; health insurance package. Our goal is that everyone in the 4. care is focused on prevention and health instead of Netherlands - rich and poor, young and old, healthy and sick - can receive good care. Now and in the future. on sickness, and it contributes to the self-reliance and resilience of the persons concerned. Action Plan: Appropriate Care Like in many other developed countries, the quality, A new way of conducting HTA affordability and accessibility of health care in the With principle 1 we intend to adapt our way of conducting Netherlands is under pressure due to an ageing population, Health Technology Assessment (HTA), in which there is workforce shortages and rising costs of new medicines and more room for a “lifecycle approach”. To facilitate this long-term care. This necessitates making different choices development, we are also actively investing in international together now to ensure good health care in the future. HTA collaborations such as EUnetHTA21 and H2020-HTx. Together with the Dutch Health Care Authority, we developed Join the conversation! four principles of “appropriate care” to guide such decision- Implementing a “lifecycle approach” in HTA in accordance to these making. In our view, appropriate care is defined as care that principles will be a real challenge. Visit our conference booth in the Expo complies with the following four principles: Hall to learn more about our international agenda and to let us know what you think about these principles and what needs to be done to put them in practice! https://english.zorginstituutnederland.nl www.linkedin.com/company/cvz/ https://twitter.com/zinlactueel 4

Introduction

INTRODUCTION President’s Welcome Dear Friends and Colleagues, pandemic not only presented serious challenges for health systems and wider On behalf of the HTAi Secretariat and the economies around the globe; it also Board of Directors, allow me to offer a created challenges to health technology warm greeting to all of you who are with us assessment bodies in determining the online and here in Utrecht - a breathtaking value of COVID-19 interventions. These city known for its rich history and culture challenges include a lack of high-quality that started as far back as 11,000 Before clinical effectiveness evidence, difficulties in Christ. estimating and assessing cost-effectiveness, and last but not least ethical issues are I would like to emphasize that we are a often not considered. In addition, the policy global, professional society dedicated and regulatory landscape for approving to making healthcare more accessible, new health technologies has changed equitable and impactful. In this capacity, dramatically, not alone as a consequence we have a responsibility to contribute to a of COVID-19. Let us discuss during the better world and to commit ourselves to coming two and a half-day to what extent the goals of peace, respect, equality, and a lifecycle approach could address some freedom. The military invasion of Ukraine is of these challenges that we pose as HTA a reminder, if we needed one, that peace is community. never to be taken for granted. We already had two days of amazing pre- We should not forget that humanitarian conference workshops and a wonderful aid is still urgently needed in Ukraine as welcome reception last night. Currently, well as in other countries that suffer from we are looking forward to a spectacular challenges such as civil wars, drought, program of keynote speeches. plenaries, pandemics, and of course, armed conflict. sponsored symposia, panels, poster and oral We stand with and support all our members presentations all featuring the world’s great that suffer from these challenges. I am minds in health technology assessment. proud to be part of a Society which We are also offering specially curated advocates for peace and continues to build entertainment and networking. The next bridges and connect everyone involved in few days will be an extraordinary gathering the HTA process. for all interested in HTA. As such, and after two years of virtual It is a tremendous task to organize a annual meetings due to the COVID-19 hybrid meeting of this scale. We genuinely pandemic, I am excited and grateful appreciate all the support from the that HTAi is convening its first “hybrid” country’s various public and private sector meeting here in my home country, the organizations who helped organize this Netherlands. This will be an opportunity event. for the HTAi community to come together both in-person and online for extraordinary I’d like to thank all the HTAi staff who made discussions of the theme of this year’s this happen, including many volunteers. annual meeting: a lifecycle approach to I am also very grateful to our 2022 determine the value of health technologies. Annual Meeting local host – Zorginstituut Nederland (National Health Care Institute) We all are aware that the COVID-19 and all our sponsors for their strong support 6

INTRODUCTION in these extraordinary times, particularly Finally, I would like to end with a statement when we moved from a virtual to a hybrid from Benjamin Franklin, an eighteenth- meeting. century scientist and founder of the American Philosophical Society. He initiated I also would like to thank the International this Society in 1743 for the purpose of Scientific Program Committee under the “promoting useful knowledge” and he wonderful leadership of the Co-Chairs Ann stated the following: Single from Patient Voice Initiative, Australia also being the Chair of HTAi’s Patient and “Tell me and I forget, teach me and I Citizens Interest Group, Dr. Wim Goettsch remember, involve me and I learn.” from Zorginstituut Nederland & Utrecht University, Netherlands and Professor Gert His spirit of inquiry, providing a forum for Jan van der Wilt from Radboud university the exchange of knowledge and views medical centre, Netherlands. They really between all relevant stakeholders, is clearly have done a great job in concluding an reflected in the new definition of HTA. It amazing and exciting programme on a also conveys my conviction that integrating challenging topic. empirical analysis and normative inquiry in a transparent way are inherently in the best I extend my gratitude to the Local interest of the public. Organizing Committee and its Co-chairs: my esteemed colleagues Professor Diana Thank you and I look forward to connecting Delnoij from Zorginstituut Nederland with you and learning from you! (National Health Care Institute), Professor Aukje Mantel-Teeuwisse from Utrecht Truly yours, University and Professor Patrick Jeurissen from Radboud university medical centre. Dr. Wija Oortwijn We hope that you feel the Dutch flavour at HTAi President the meeting, and as the flowers. I hope that our Annual Meeting will be an engaging and enlightening opportunity for all of you with an interest in HTA to gather as a community of peers and reflect on how a Lifecycle approach can shape the future – all in service of better evidence, better methods, and better decisions for patients. Enjoy the opportunity to reconnect with old friends and colleagues, engage in lively discussions and debates, let off some steam, and make new connections. I hope that after the meeting, you feel both informed and motivated in your future work. And please share your experience throughout the meeting on social media with the hashtag #HTAi2022Utrecht 7

INTRODUCTION Local Organizing Committee Co-Chair’s Message workforce shortages and rising costs. Such circumstances necessitates decisive action Dear Friends and Colleagues, based on the best available knowledge, which HTA can and should provide. On behalf of the Local Organizing In doing so, HTA itself is developing Committee (LOC), it is our great pleasure by focusing on following healthcare to welcome you to the Health Technology innovations and assessing their added Assessment international (HTAi) 2022 value throughout their lifecycle. The HTAi Annual Meeting, and to the beautiful city Annual Meeting provides an important of Utrecht! platform to discuss the ways this can be accomplished and we look forward to the We would like to take this opportunity to ideas put forth by the participants of this thank all those involved in the planning conference! and organization of this year’s meeting. In particular we wish to thank the HTAi In addition to the pandemic, the conflict Team, members of the International in Ukraine has drastically changed Scientific Program Committee (ISPC) and the world in the last few months. The the Local Host Organization, Zorginstituut conflict serves as a stark reminder that Nederland, for their efforts. After two the freedoms and principles promulgated virtual editions, the meeting in Utrecht will by liberal democracies over the last 75 be hybrid. We look forward to connecting years (e.g. tolerance of difference, respect with old (and new) friends and colleagues. for individual- and human rights, rule of law) are more fragile than anticipated. With Utrecht as our venue, we have an Our thoughts are with those affected inspirational backdrop for the conference. by the conflict. Most importantly, since Located centrally in the Netherlands, accessibility to care is a fundamental Utrecht has a rich and vibrant history human right we hope the conflict will be dating back to the Roman Empire. During resolved quickly and peacefully, so that and after the reformation, it was both a we can once again work together with our strategically important city for commerce HTA colleagues towards that goal. as well as a safe-haven for those sheltering from (religious) oppression and We hope you will enjoy your time at the war in other parts of Europe We hope the Annual Meeting and that you will make delegates of the conference will feel at the most out of the Scientific and Social home and we encourage them to explore Program - we look forward to meeting the beautiful city center. you there! We realize the Annual Meeting will take Prof. Diana Delnoij place during tumultuous times. For over Departmental Head Research & two years healthcare systems across the Development and International Affairs world have operated in a crisis mode and while the immediate crisis might seem Prof. Aukje Mantel-Teeuwisse over, the backlog of outstanding care will University, the Netherlands continue to put strain on systems already under pressure due to aging populations, Prof. Patrick Jeurissen Professor Sustainable Healthcare Systems, Radboud University 8

INTRODUCTION Local Organizing Committee Co-Chairs Pharmacoepidemiology and Clinical Pharmacology of Utrecht University. Prof. Diana M.J. Delnoij, The Division is part of the Research PhD Network Health Technology Assessment & Appraisal, a collaboration between UU, the Departmental Head Research & National Health Care Institute and ESHPM Development and International (Erasmus University). At present, she is Affairs also the Scientific Director of the WHO Collaborating Centre of Pharmaceutical Diana Delnoij, PhD, is chief Policy and Regulation. The Centre works scientific officer of the National Health closely together with WHO HQ, WHO Care Institute (0.7 FTE) and she holds an Collaborating Centres and a wide range endowed chair as professor of Governing of other stakeholders in the field of Healthcare Quality and Efficiency at pharmaceutical policies and access to the Erasmus School of Health Policy & medicines. Her research interests include Management (0.3 FTE). Diana is a political global health, pharmaceutical policy scientist with 35 years of experience in analysis, drug regulatory science, and health services research. variation in medicines use across countries. As chief scientific officer she advises the Aukje has been appointed Director of the National Health Care Institute’s board and School of Pharmacy at Utrecht University management on strategic R&D policy, and since 1 July 2014. In this capacity she is she is responsible for building networks member of a number of (international) with relevant academic and public partners, and external representation in academic committees and working groups. settings. In her academic work, she focuses on topics such as governance issues in Prof. Patrick Jeurissen health technology assessment, value- based healthcare, and measuring quality Professor Sustainable and outcomes of care from the patient’s Healthcare Systems, Radboud perspective. University Internationally, Diana is active as chair of the International Horizon Scanning Initiative Patrick Jeurissen, Ph.D., (IHSI), a member of the NIHR Applied is a full-time professor in Research Collaboration West Midlands fiscal sustainable health care systems at Scientific Advisory Group, and as editor of Radboud University Medical School (0.8 the European Journal of Public Health. fte) and Science Officer (0.2 fte) of the Ministry of Health, Welfare and Sports in the Prof. Aukje Mantel- Netherlands. Jeurissen is an expert on the Teeuwisse design and implementation of policies that specifically address issues of sustainability Prof. of Pharmacy and Global and affordability of health care systems. Health, Utrecht University He has (co)-authored some one-hundred scientific publications, and was a co-editor Aukje is a professor of two books on the subject; he is also a of Pharmacy and sought speaker on (inter)national forums. Global Health at the Division of Patrick represents the Dutch government at 9

INTRODUCTION OECD. He also has been an advisor for EU, • D r. Hanneke van Dongen, Assistant WHO, OECD, and different governments Professor Economic Evaluations of across Europe on issues of healthcare Healthcare, VU Medisch Centrum, reform and fiscal sustainability. His major Netherlands interests are: strategic policymaking, health care finance and cost-containment policies, • Dr. Cor Oosterwijk, Director, VSOP for-profit providers and payers, solidarity Nederland, Netherlands in health care systems, hospitals, and comparative health care system research. • Prof. Dr. Michel van Agthoven, Director Currently, his focus within these areas External Affairs, Janssen, Netherlands is on tertiary care, multimorbidity, and administrative costs. He holds a Ph.D. in Local Host Project health economics, his dissertation covers Management for-profit hospital ownership in the US, the UK, Germany, and the Netherlands, • M r. Maarten de Haan, Project Manager and holds an M.P.A., both from Erasmus HTAi 2022, Zorginstituut Nederland University in Rotterdam. • Mr. Jeroen Duijvestjn, Communication Members Officer, Zorginstituut Nederland • Dr. Mariëlle Snijders, Departmental • D r. Hedi Schelleman, Observer, Head Efficiency Research Zorginstituut Nederland (Doelmatigheidsonderzoek), ZonMw, Netherlands • Prof. Dr. Ardine de Wit, Health economist and endowed Professor, Senior Researcher/Health Economist (& Associate Professor UMC Utrecht), National Institute for Public Health and the Environment (RIVM) & Vrije Universiteit Amsterdam, Netherlands • Mr. Ruud Koolen, Director, Utrecht Health Hub, Netherlands • Dr. Xavier Pouwels, Post-Doctoral Researcher, Universiteit Twente, Netherlands • Dr. Linetta Koppert, Oncological Surgeon / Clinical Epidemiologist, ErasmusMC, Netherlands • Mrs. mr. Linda Daniels - van Saase, Manager, NPF, Netherlands • Dr. Leo van Rossum, Strategic Policy Advisor, Nederlandse Huisartsen Genootschap, Netherlands • P rof. Dr. Ton de Boer, Chair Medicines Evaluation Board, CBG en Utrecht University, Netherlands 10

INTRODUCTION International Scientific Program Committee (ISPC) Co-Chairs’ Message international collaboration, and explore the potential consequences. HTAi 2022 Hybrid Annual Meeting– ‘Lifecycle Approach: With this in mind, we welcome new and Coming Together to Make it familiar faces to HTAi 2022 Annual Meeting Happen’ whether you are in Utrecht or online. Together we form a multi-disciplinary, After months of cautious optimism, we write multi-stakeholder community from around this welcome with excitement and gratitude the lifecycle and globe that can thrive on as we begin to believe that many of us will our diversity of knowledge, experience and actually come together in person for HTAi perspectives. In line with this, we’re pleased Annual Meeting after three difficult years to share that this year’s program has a strong apart. Furthermore, our gathering will not contribution from people from low- and be limited to those able to travel to Utrecht middle-income countries. We also have but will include the active participation of more patients, and their representatives, anyone able to join virtually. Since we met than ever in attendance, including a patient in Cologne, we’ve experienced the isolation representative speaker in all three plenaries and despair wrought by the Covid-19 and patients presenting on many panels. pandemic. We may also have witnessed the value of collaboration and our perceptions of To structure our thinking about a lifecycle what is possible may have been re-framed. approach to HTA we have developed three sub-themes: ‘Coming together is key to this year’s theme of a lifecycle approach to HTA. It’s an • Adopting a Lifecycle Approach in HTA: approach that reflects the idea that a one-off Consequences for Priority-Setting and HTA can be insufficient for understanding International Collaboration the changing value of technology as it moves from pre-market, market approval, • Public Confidence in Healthcare post-market and eventual disinvestment in Decision-Making a shifting health and evidence landscape. It’s been suggested that this approach should • Running Around in Circles; Time for Real entail continuous dialogue and the exchange Collaboration between Regulators, HTA of knowledge between all stakeholders while Bodies and Clinicians. ensuring that better outcomes for patients are central to the activities of HTA bodies. We thank the members of the International Scientific Program Committee for working If a lifecycle approach is to achieve those with us to create a stimulating program to ambitions and meet the challenges of enable us to deepen our understanding of innovative and novel technologies, we the consequences of a lifecycle approach must find ways to bring together disparate to HTA. We wish you a productive and fun stakeholders and data requirements. meeting filled with unexpected insights, We must agree priorities, foster better thoughtful Q&As, new connections with people and ideas, and a renewed optimism for HTA and your role in its judicious use to improve people’s lives. 11

INTRODUCTION HTAi 2022 International Scientific Program Committee (ISPC) Co-Chairs Dr. Wim Goettsch Prof. Prof. Gert Jan van Dr. Wim Goettsch, Ph.D. der Wilt is currently Special Advisor HTA at the Dutch Prof. Gert Jan van der National Health Care Wilt (1958) received his Institute He was the Ph.D. in Neuroscience Director of the EUnetHTA JA3 (2016-2021). from VU University, Directorate and Chair of the Executive Amsterdam. After an initial focus on basic Board of EUnetHTA between June 2016 science, he developed an interest in the and March 2018. Since 2019, he also has broader social and ethical implications of had a position as an Associate Professor new developments in neuroscience, such at Utrecht University (NL) where he is as the grafting of fetal tissue in the brain of leading a new H2020 consortium with patients with Parkinson’s disease. To pursue fifteen partners around Europe, called HTx this further, he was visiting scientist at the on new methods for Health Technology Hastings Center (NY), and was appointed a Assessment for personalized medicine post-doctoral fellow at the Institute of Ethics (2019-2024). Between 2010 and 2013, he of VU University, Amsterdam. In 1994, he was the Deputy Secretary of the Medicinal joined the Department of Health Technology Products Reimbursement Committee at the Assessment (HTA) of Radboud University, Dutch National Health Care Institute. He is where he was appointed head (1996) and currently a Director on the Board of HTAi full professor of HTA (2000). From 2000 to (2019-2022). Before joining the National 2010, he also held a chair in interactive HTA Health Care Institute, he worked as a at the Athena Institute for Innovation and research manager for the PHARMO Institute Communication in the Health Sciences at and was responsible for the coordination of VU University, Amsterdam. He was visiting numerous pharmacoepidemiological and scientist at the TC Chan School of Public outcomes studies for international offices Health, Harvard University (2018), and a of pharmaceutical companies such as fellow of the Institute of Advanced Study AstraZeneca, Novartis, Pfizer, and GSK. He of Durham University, UK (2019). He served has a Ph.D. in immunology and advanced on the National Appraisal Committee of education in (pharmaco)- epidemiology the Netherlands and was vice-chair of the and pharmaco-economics. He has more Population Screening Committee of the than 100 publications in peer-reviewed Dutch Health Council. He was co-chair of international journals. the Interest Group on Ethics of HTAi, and a member of HTAi’s Scientific Development and Capacity Building committee. He participated in the EU-project INTEGRATE- HTA and coordinated the VALIDATE project, funded by the Erasmus+ program of the EU. His main research interest is in the interplay of facts and values in the evaluation of healthcare technologies. 12

INTRODUCTION Ms. Ann Single Members Ann became Chair of the • Dr. Andres Pichon, Executive Director, HTAi Patient and Citizen Argentina  Involvement Interest Group (PCIG) in 2019 • Mr. Meindert Boysen, Director of after being an active the Centre for Health Technology member of PCIG since Evaluation, National Institute for Health 2006. Her interest in this area began when and Care Excellence, UK she directed patient involvement and communication in Scotland’s first HTA • Dr. Claudia Wild, Chief Executive, AIHTA body and later established involvement GesmbH processes for the Scottish Medicines Consortium. She is co-editor of the first • Mr. Parashar Pate, Senior Vice book in the field, Patient Involvement in President, Government Affairs & Market Health Technology Assessment (2017). Her Access, ViewRay Inc., USA current wider work includes provide training and support for patients wanting to engage • Prof. Tracy Merlin, Professor / Director, with HTA in Australia, co-developing and AHTA; Interim Head, School of Public trialling a mentoring program for consumer Health, Australia  members on Australian HTA committees, and contributing to PCIG projects on • Prof. Rabia Kahveci, Senior Technical impact as well as patient participation at Advisor, SafeMed, Ukraine  the organizational level in HTA bodies. Ann recently accepted an invitation to serve as • Mrs. Nuriya Musina, Associate a patient representative on the Reference Professor, Center of Healthcare Quality Committee for the Australian Government’s Assessment and Control, Russia HTA Policy and Methods Review. • Dr. Iga Lipska, Hospital Based HTA Project Leader, National Health Fund, Poland • Ms. Maoling Wei, The Center for Evidence-based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, China • Dr. Armina Padmasawitri, Lecturer, School of Pharmacy, Institut Teknologi Bandung, Indonesia • Dr. Ryota Nakamura, Professor, Hitotsuhashi Institute for Advanced Study (HIAS) Health, Japan • Prof. Dr. Judith E. Bosmans, Professor, Vrije Universiteit Medical Center, Netherlands • Dr. Massoud Toussi, Senior Principal, Real World & Analytics Solutions, IQVIA, France • Mr. Ivett Jakab, President, EPF Youth Group and Syreon Research Institute, Hungary • Prof. Chiara de Waure, Associate Professor, University Perugia, Italy 13

INTRODUCTION • Dr. Rosmin Esmail, Provincial Trauma Technology Assessment Section Epidemiologist, Alberta Health Services, (MaHTAS), Medical Develoment Division, Canada Ministry of Health, Malaysia • Mr. Ken Bond, Director, HTA and • Dr. Aurelio Meija, Director of Regulation External Relationships, Institute of Ministry of Trade, Industry and Tourism, Health Economics, Canada Colombia • Prof. Guy Maddern, RP Jepson • Dr. Jo Carol Hiatt, Vice President, Professor of Surgery, University of Medical Device Innovation Consortium, Adelaide, Australia United States • Ms. Dima Samaha, Principal, Real World • Dr. Jon Campbell, SVP For Health Solutions, United Kingdom Economics, ICER, USA • Dr. Joice Valentim, Global HTA Strategy • Dr. Mouna Jameleddine, Director, HTA Lead, Roche Department, INEAS, INAHTA, Tunisia • Mrs. Ursula Giedion, Coordinator, Technical Officer Global HTA Strategy Lead, Roche • Dr. Saskia Knies, Senior Advisor, • Dr. Alric Ruether, Head of International National Health Care Institute Affairs, Institute for Quality and (Zorginstituut Nederland), Efficiency in Health Care (IQWiG), Netherlands Germany • Dr. Izzuna Mudla Mohamed Ghazali, Deputy Director, Malaysian Health The Institute of Health Economics is wishing all HTAi delegates productive learning and engaged debate on lifecycle HTA Scan the code to learn more 14

INTRODUCTION About HTAi Health Technology Assessment international our many Interest Groups.  Organizational (HTAi) is a global, non-profit, scientific, Members are eligible for an invitation to our and professional society for all those Policy Forums (Global, Latin America, and who produce, use or encounter health Asia) and our Annual Meeting is a draw for technology assessment (HTA). We are an many of our members. open platform for global collaboration that leverages and shares collective intelligence These unique platforms allow members to improve health outcomes worldwide - to participate in face-to-face discussions making health care more accessible, more and be part of the critical conversations equitable, and more impactful. HTAi was that help inform policy on the use of founded in 2003 and has since contributed technologies in healthcare assessment. to the global health ecosystem and HTA This collaboration ensures a balance of learning through our international Annual ideas from the broad HTA community. Our Meetings, Policy Forums, Interest Groups, networking and partnership opportunities journal publications, and more. have been identified as truly unique by our members and we pride ourselves on Membership bringing the world together to foster better healthcare through HTA. HTAi is a member-driven organization that represents a variety of stakeholders who This collaboration ensures a balance of have interests in HTA, including researchers, ideas from the broad HTA community. Our policy makers, industry, academia, networking and partnership opportunities health service providers, agencies, and have been identified as truly unique by patients who contribute to the balanced our members and we pride ourselves on conversation around HTA across different bringing the world together to foster better areas of practice and jurisdictions. healthcare through HTA. HTAi members share a commitment to extending the conversation beyond the traditional bounds of industry or professional bodies by including those impacted by the conversations, and those whose decision making is influenced by the outcomes of HTA research. Our broad community of members use HTAi as an open platform for collaboration, as we all seek ways to use HTA to improve global health. HTAi Members benefit by having free online access to the International Journal of Technology and Assessment in Health Care, access to webinars and HTA resources and are welcome and encouraged to join one of 15

INTRODUCTION HTAi Board of Directors 2021-2022 President Directors Dr. Wija Oortwijn Netherlands Vania Canuto (2021-23) Brazil (2020-23) Vice President Dr. Rabia Kahveci Dr. Wim Goettsch Ukraine Netherlands (2021-23) (2019-22) Treasurer Dr. Catherine Holliday Dr. Americo Cicchetti Switzerland Italy (2019-22) (2021-24) Debjani Mueller Secretary South Africa Dr. Jo Carol Hiatt (2019-22) USA (2021-24) Dr. Leonor Varela-Lema Spain Past President (2019-22) Dr. Iñaki Gutierrez-Ibarluzea Spain Dr. Franz Waibel (2021-23) Switzerland (2020-23) Dr. Li Ying (Grace) Huang Taiwan (2020-23) Board Observers Policy Fora Chairs Prof. Wendy Babidge Dr. Dan Ollendorf Australia USA, HTAi Global Policy Forum Editor-in-Chief, International Chair (2020-22) Journal of Technology Assessment in Health Care Dr. Manuel Antonio Espinoza HTAi Latin America Policy Forum Prof. Tracy Merlin Chair (2022-24) Australia INAHTA Prof. Guy Maddern HTAi Asia Policy Forum Chair (2022-24) 16

INTRODUCTION Interest Groups As a member of HTAi, you are invited to Disinvestment and Early Awareness (DEA) join one or more of the ten Interest Groups • Chair: Rosmin Esmail (Canada) to share international experiences and • Co-Chair: Nora Ibargoyen Roteta (Spain) expertise among HTA users and producers • Technical Officer: Anna Lien Espeland worldwide. (Norway) The ten Interest Groups currently housed at Early Career Network (ECN) HTAi are: • Co-Chair: Maoling Wei (China) • Co-Chair: Denny John (India) • Disinvestment and Early Awareness • Technical Officer: Vacant • D eveloping Countries • E arly Career Network Ethical Issues in HTA (ETH) • Ethical Issues in HTA • Chair: Ken Bond (Canada) • H ospital-Based HTA • Co-Chair: Dario Sacchini (Italy) • I nformation Retrieval • Technical Officer: Sylvia Nabukenya (Uganda) • M edical Devices • Patient and Citizen Involvement Hospital-based HTA (HB-HTA) • Public Health • Co-Chair: Americo Cicchetti (Italy) • R eal World Evidence and Artificial • Co-Chair: Marco Marchetti (Italy) • Technical Officer: Vacant Intelligence HTA in Developing Countries (DCIG) The Interest Groups (IGs) serve as • Chair: Jani Mueller (South Africa) professional and scientific fora for all those • Technical Officer: Yves Miel Zuniga who undertake and use HTA in health (Philippines) care, business, government, academic institutions, and consultancies. Information Retrieval (IRG) • Chair: Ingrid Harboe (Norway) HTAi members can utilize the unique • Co-Chair: Amanda Hodgson (Canada) experience created by the Interest Groups • Technical Officer: Gabriela Vilela de and can network and exchange information, Brito (Brazil) or even collaborate on projects. Medical Devices (MDIG) IG members share topic updates, participate • Chair: Richard Charter (Switzerland)) in the development of new research and • Co- Chair: Anastasia Chalkidou (UK) useful material, and develop workshops and • Technical Officer: Victoria Hurtado (Chile) training sessions. Patient and Citizen Involvement (PCIG) There are also opportunities for IG • Chair: Ann Single (Australia) members to be involved in activities directly • Technical Officer: Veronica Lopez-Gousset funded by HTAi. (France) Please feel free to attend any of the IG Public Health (PHIG) Business Meetings. This will be held in • Chair: Maarten Postma (Netherlands) concomitance to the Annual Meeting. • Technical Officer: Vacant Should you wish to join a specific Interest Real World Evidence and Artificial Intelligence Group’s listserv, please send the request to (RWE-AI) [email protected]. • Chair: Massoud Toussi (France) • Co-Chair: Dimitra Lingri (Greece) • Co-Chair: Elena Petelos (Netherlands) • Technical Officers: Alessandra Blonda and Sophia Valaris 17

INTRODUCTION HTAi Policy Forums Launched in 2003, and having since Findings from the most recent Policy Forums expanded, HTAi currently hosts three Policy will be presented at this Annual Meeting Forums throughout the year: the Global during the following panel sessions: Policy Forum (GPF), the Asia Policy Forum (APF) and the Latin America Policy Forum HTA 2025 and Beyond: Lifecycle (LATAM PF). Each Forum is by invitation Approaches to Promote Engagement and only, bringing together some of the most Efficiency in Health Technology Assessment senior representatives in the field of HTA (2022 Global Policy Forum) to participate in strategic discussions surrounding the present state of HTA and its Monday, June 27 development around the world. The Forums 14:20 – 15:35 provide the opportunity to interact and network with various stakeholders on a one- Deliberative Processes for Informed on-one basis, have open group discussions Decision Making by Health Technology around relevant and pertinent topics, and Assessment (2021 Latin America Policy have direct impact on local HTA policies. Forum) Monday, June 27 Topics discussed at the Policy Forums 17:15 – 18:30 are diverse and complex, considering the pressing policy issues for HTA. Past Forums HTA in Asia Post-COVID-19 (2021 Asia have tackled topics such as: Lifecycle Policy Forum Approaches in HTA, Sustainability of Tuesday, June 28 Healthcare Systems in Asia, and Stakeholder 16:55 – 18:10 Involvement in the Health Technology Assessment Process in Latin America. For more information or questions regarding Reports from all the Policy Forum meetings the Policy Forums, please contact our Events are published in the society’s official journal, Manager, Ali Powers at [email protected]. at the International Journal of Technology [email protected]. Assessment in Health Care (IJTAHC). The Global Policy Forum will host a Business and Topic Scoping meeting for HTAi members on Sunday, June 26 from 09:00 – 12:00. 18

INTRODUCTION Partnerships HTAi is strongly committed to international collaboration. In addition to official relations status with the World Health Organization, we have signed formal Memoranda of Understanding with INAHTA, ISQua and EuroScan. HTAi also collaborates with organizational members and regularly works with other like-minded organizations. World Health Organization In January 2015, HTAi became a Nongovernmental Organisation in Official Relations with the World Health Organization. EuroScan EuroScan, the International Information Network on New and Emerging Health Technologies, is a collaborative network of member agencies for the exchange of information on important new and emerging health technologies, including drugs, devices, diagnostics, procedures, programs and settings. INAHTA The International Network of Agencies for Health Technology Assessment (INAHTA) is a network of 51 publicly funded HTA agencies that support health system decision making that affect over one billion people in 31 countries around the globe. INAHTA brings HTA agencies together to share knowledge and tools to strengthen their role as essential contributors to health outcomes and health system sustainability. ISQua The International Society for Quality in Health Care (ISQua) is a global organization with origins dating back to 1984. Its mission is to inspire and drive improvement in the quality and safety of healthcare worldwide through education and knowledge sharing, external evaluation, supporting health systems and connecting people through a global network that spans 100 countries and five continents. HTAsiaLink HTAsiaLink is a collaborative research network of Health Technology Assessment (HTA) agencies in the Asia-Pacific region established on September 2010. The network started with an aim to strengthen Health Technology Assessment (HTA) research efficiency by sharing HTA information, experiences, and resources within the members. HTAsiaLink also focuses on promoting HTA utilization, developing an efficient methodology for HTA, and encouraging HTA evidences implementation for Universal Health Coverage. 19

INTRODUCTION HTAi Secretariat The HTAi Secretariat is based in Edmonton, Alberta (CANADA), and provides professional strategic and managerial support to our Board of Directors, committees, and members, while executing all HTAi activities. Health Technology Assessment international (HTAi) 1280 5555 Calgary Trail, Edmonton Alberta T6H 5P9 [email protected] HTAi.org Rob Abbott Hana Price Executive Director Senior Events Coordinator [email protected] [email protected] Melissa Donecz Breanne Dickhout Manager of Finance Events Coordinator [email protected] [email protected] Denise Jarrett Bryce Doherty Annual Meeting Manager Technology Lead [email protected] [email protected] Antonio Migliore Gerardo Cea Manager of Scientific Coordinator, Technology Initiatives [email protected] [email protected] Evani Goll Ali Powers Senior Coordinator, Events Manager Membership [email protected] [email protected] Tatiana Hagerty Naomi Suwinski Senior Coordinator, Communications Lead Governance [email protected] [email protected] Amren Thakur Annual Meeting Committee Liaison [email protected] 20

General Information

GENERAL INFORMATION General Information About Utrecht Money Utrecht is the lively, beating heart of Holland. The official currency of the Netherlands It was built around the Dom tower, which you is the Euro (EUR) but foreign currency can see from any point in the city, so there is readily exchange at the airport and all is no way you can get lost in the attractive, major banks. There are eight coins (€ 0.01, car-free city centre. Utrecht boasts beautiful € 0.02, € 0.05, € 0.10, € 0.20, € 0.50, € 1 canals with extraordinary wharf cellars housing and € 2) and seven notes (€ 5, € 10, € 20, cafés and terraces by the water. As well as the € 50, € 100, € 200 and € 500). Very few Dom tower, Utrecht boasts hundreds of other shops, restaurants, etc., accept the € 500 monuments that each contribute to the special note. Small shops and supermarkets do atmosphere in this centuries-old university not accept the € 200 and € 100 notes town. either. When you pay in cash, the amount is rounded off to the nearest € 0.05. Dutch is the official language in the Netherlands, but most Dutch people speak ATMs English and often a bit of German or French as well. If you have a foreign bank card with a Cirrus logo you can get money from an Automatic For more information about Utrecht, visit the Teller Machine (ATM). Some ABN AMRO Netherlands tourism website: https://www. bank ATMs also accept cards with the PLUS holland.com logo. Also check your card and the ATM for EDC, EC and Maestro logos. You can also COVID-19 Information for use most credit cards to obtain money from Visitors to the Netherlands an ATM. All COVID-19 related measures have been Gratuity abolished in the Netherlands. The travel rules for entering the Netherlands have In The Netherlands, Value Added Tax and been eased as well. service charges are included in your check in hotels, restaurants, shops and taxis. Tips for Travelers to the Netherlands coming from extra service are always appreciated but not within the EU/Schengen Area no longer required. It is customary to give taxi drivers require a test, proof of recovery or proof of and waiters a tip of about 10 percent. Many vaccination. public restRooms have an attendant who is usually tipped EUR 0,50. Travellers from outside the EU/Schengen area no longer have to carry a negative test Electricity result, if one of the following applies: Their country of origin is on the EU’s list of safe The voltage outlets in the Netherlands is 230 countries, they hold a valid vaccination volts. Travellers are advised to bring a power certificate or recovery certificate. converter and an adapter for round tow-prong plugs with side grounding contacts. You can find up to date information and travel advice at https://www.government.nl. 22

GENERAL INFORMATION Medical Information Access and Security We hope that everyone stays healthy Name badges will be provided to during the Annual Meeting, but accidents all delegates and participants at the can happen and sometimes you may need Registration/Check-in Desk. The badge is medical assistance. Medical care is very well your admission pass to all Annual Meeting organized in Holland. sessions and the exhibit areas. Tickets will be printed and provided for all social events. Insurance Delegates are required to wear their name badge at all times and will not be It is strongly recommended that those granted access to the conference without attending/participating in HTAi 2022 them. This is to ensure tat access to the purchase adequate coverage for health, conference is properly managed. travel and private liability insurance before departing their home countries. The Annual Meeting organizers will not accept responsibility for Registration/Check-in Desk personal injury, loss or damage to private or personal property of conference attendants/ The registration desk is located in the foyer participants and/or accompanying persons. of the Beatrix building on the ground floor and will be open during the following times: Annual Meeting Dates • Saturday, June 25: 07:45 – 17:00 June 25-29, 2022 • Sunday, June 26: 07:45 – 20:30 Annual Meeting Venue (In Person) • Monday, June 27: 07:15 – 19:00 Beatrix Building, Jaarbeurs, Jaarbeursplein, • Tuesday, June 28: 07:30 – 18:00 3521 AL Utrecht, Netherlands • Wednesday, June 29:08:00 – 11:00 Tel: +31 30 295 5911 Annual Meeting Timetable https://www.jaarbeurs.nl All HTAi 2022 Annual Meeting sessions will Annual Meeting Secretariat be held in the Beatrix Building, Jaarbeurs. Please consult the program or the App for HTAi Annual Meeting Management: detailed timing of all sessions, meetings and HTAi Secretariat refreshment breaks. All references to time Health Technology Assessment international within this program are noted in Central (HTAi) European Summer Time (CEST), UTC+2. 1280 5555 Calgary Trail, Edmonton Alberta T6H 5P9 Annual meeting App [email protected], www.htai.org Download the HTAi 2022 App for the full Annual Meeting experience! The App is available for download free-of-charge at the Apple and Google Play stores. Once downloaded be sure to sign in using your HTAi login and app code “htai-2022” to connect with your peers. 23

GENERAL INFORMATION HTAi Annual Meeting App HTML5 App: Event Code: htai-2022 Install URL: https://htai.eventsair. How to use the app: com/attendeeapp/htai-2022-utrecht- annual-meeting/htai-2022-utrecht 1. Install the app from one of the provided URL’s. 2. Open the app and input the event code htai-2022 3. Log in using your HTAi log in and app code or password. IOS App: Navigating the App: Install URL: https://itunes.apple.com/ Log In: This is where you can log in to the app to us/app/the-event-app-by-eventsair/ access the full benefits. Please use your HTAi log id1142851582?ls=1&mt=8 in information. Android App: Alerts: Any notices or alerts sent by the event organizer will be found here. Install URL: https://play.google.com/ store/apps/details?id=com.eventsair. Agenda: This is the full agenda for the HTAi attendeeapp Annual Meeting. While scrolling through sessions you can see timing, Room information, speakers, a description, polling, Q and A, and any hand outs. If a session interests you be sure to favourite it as well. My Agenda: This will only show sessions which you have favourited or starred. Meeting Hub: A way to connect with other event attendees and communicate. Sponsors: Where you can access information and materials provided by this years sponsors. Live Support: You have access to virtual support through the app. Select this to be in contact with one of HTAi’s Secretariat who is happy to assist you. FAQ: A short FAQ for the event. Privacy and Settings: Here you can adjust your privacy settings for the event app. Log Out: Log out of the app. 24

GENERAL INFORMATION Exhibit Area Hours Lost property The exhibit tables are located on the ground Any found items will be stored at the Beatrix floor in the Expo Hall and will be open at Building reception desk. After the Annual the following times: Meeting, all found items will be placed on the following site: https://ilost.co/nl/org/ • Monday, June 27: 10:00 – 18:00 jaarbeurs  • Tuesday, June 28: 09:30 – 19:00 • Wednesday, June 29: 08:00 – 14:00 Annual Meeting Language Posters The official language of the HTAi 2022 Annual Meeting is English and all sessions Posters are displayed in the Expo Hall will be conducted in English. on digital poster columns, on the virtual meeting platform and can be accessed Photography, Audio and through the Annual Meeting App. Facilitated Video Recordings poster presentations are scheduled during lunch breaks on Monday 27 and Tuesday 28 By attending the HTAi 2022 Annual June. See the program for more details. Meeting, the participant understands and provides consent to being photographed Speaker Ready Room/Slide or being recorded by means of video or Preview Room audiotape recording by the Organizers, or a designated representative of the Organizers. TThe Speaker Ready Room is available in These photographs and/or recordings can Room 310 on the 3rd floor of the Beatrix be used, without compensation to the Building. Pre upload of presentations is Delegate, in any public display, publication mandatory, but speakers are requested or media, or website, or in any manner or to visit the Speaker Ready Room at least form, and at any time by the Organizers in 2 hours before their presentation (or, if promotion of the mission to promote the their session starts at 08:00, by 18:00 the Annual Meeting. The participant releases previous day) to ensure their upload is the Organizers, and their employees, complete and displaying accurately. The agents, representatives, associates, Board Speaker Ready Room will be open at the of Director members, and consultants from following times any liability in connection with the use of such photographic, video and/or audio • Saturday, June 25: 07:30 – 17:00 materials. • Sunday, June 26: 07:30 – 18:00 • Monday, June 27: 07:30 – 19:00 Refreshment Breaks and • Tuesday, June 28: 07:30 – 19:00 Lunch • Wednesday, June 29: 07:30 – 09:30 All refreshment breaks and lunch will be Annual Meeting Wifi served in the Expo Hall (Ground Floor). For those attending sponsored symposia Complimentary wifi service is provided by or business meetings during lunch breaks, the conference and available through the a pre-packed lunch bag can be collected common areas and meeting spaces of the from the 1st floor foyer. Beatrix Building. 25

GENERAL INFORMATION Floor plans Beatrix Theatre Ground Floor plan Ingang Jaarbeursplein podium lift lift Mies Bouwman Lift Lift Foyer Trap Registration vrije hoogte 2.70 m vrije hoogte onder koof 2.75 m Receptie Expo Hall Trap vrije hoogte onder koof 2.75 m Lift Lift Toilet dames Toilet heren vrije hoogte 2.70 m vrije hoogte 2.40 m 26

Beatrix Theatre GENERAL INFORMATION 1st Floor plan Beatrix Theatre Room 2nd Floor plan 117 21 116 21 lift lift registratie deuren Trademart deuren JFF 12 21 registratie lift lift 115 21 Room Room 114 215 110 210 27

GENERAL INFORMATION Beatrix Theatre 4th Floor plan Beatrix Theatre 3rd Floor plan Room 417 323 322 321 416 320 415 414 319 lift lift lift lift 412 411 318 317 lift lift 316 lift lift Room 315 311 28

GENERAL INFORMATION Virtual Annual Meeting MY SETTINGS AND UPDATING YOUR Platform PROFILE Guide to using OnAIR When you first sign on to the OnAIR platform, the Event Check-In window OnAIR is an online hub where both in displays, prompting you to update your person and virtual attendees can connect personal profile. and participate with the Annual Meeting content. The OnAIR app is useful for all The ‘About You’ section includes the attendees, both virtual and in-person. An contact details that were provided as part annual meeting attendee can look up the of your registration. Your name and email event’s agenda and session information, edit address cannot be changed as they are their profile information, connect with other linked to your account. In your ‘Profile’ you attendees in the meeting hub, take part in can add or update your picture, provide the event gamification, look at the resource your biography as well as your social media gallery, and watch virtual sessions through links. the OnAIR app. If you are viewing from outside of Canada, Both the OnAIR and annual meeting mobile we strongly suggest updating your time app can communicate, as both offer many zone on this page to display the program similar functions, including agendas, profile on the OnAIR timeline in the correct time updates and meeting hub. Gamification, for you. resource gallery and virtual sessions are exclusive to the OnAIR app. In ‘Privacy Settings’ you can decide how much or how little information you would ACCESS like to share with other attendees and OnAIR app link: ‘Media Settings’ allows you to control your camera and microphone. https://portalapp.htai.eventsair.com/ VirtualAttendeePortal/htai-2022-utrecht- To edit or change these settings at any time, annual-meeting/htai-2022-am please click on your profile photo at the top right corner of your screen and select ‘My OnAIR app QR code: Settings’. NOTE: Please use LIVE SUPPORT Google Chrome if accessing the OnAIR app via internet browser. When you first sign on to the OnAIR platform, the Event Check-In window displays, prompting you to update your personal profile. The ‘About You’ section includes the contact details that were provided as part of your registration. Your name and email address cannot be changed as they are linked to your account. In your ‘Profile’ you can add or update your picture, provide your biography as well as your social media links. If you are viewing from outside of Canada, 29

GENERAL INFORMATION we strongly suggest updating your time viewing the session, please click on the ‘Live zone on this page to display the program Support’ icon for additional assistance. on the OnAIR timeline in the correct time for you. USING THE MEETING HUB In ‘Privacy Settings’ you can decide how The Meeting Hub allows you to connect much or how little information you would and communicate with other attendees. like to share with other attendees and Once you have located an attendee you ‘Media Settings’ allows you to control your want to connect with, click the ‘Connect’ camera and microphone. button. Once the other attendee accepts your request, you can choose to interact To edit or change these settings at any time, with your connection by starting a live chat please click on your profile photo at the top or live video call. You can also schedule right corner of your screen and select ‘My to meet at a future time, send messages Settings’. and take notes. Contact information for all attendees you have connected with will be USING THE TIMELINE included when you export your contacts (see ‘Exporting your Notes and Contacts’ for Your starting point on the OnAIR meeting additional information). platform is the timeline page. Centrally on this page, you can see all the sessions VIRTUAL EXHIBITION and functions that are happening each day, listed in chronological order. You can You can visit the Virtual Exhibition at any click on any of the items in the timeline to time during the event by clicking on the view additional information and join the ‘Meet Exhibitor’ button on the right side of session or function. From any page, you can the timeline. When you are in the Virtual return to the timeline by selecting ‘Back To Exhibition Hall, you can search and browse Timeline’ displayed in the top left corner of through the list of exhibitors. Clicking your screen. on the ‘View’ button lets you review the exhibitor’s information and download any LIVE HOST available brochures. You can also choose to connect with members of the exhibitor’s At various times during the event, the ‘Live team via Meeting Hub. If the exhibition is Host’ window may appear to provide further open and the exhibitor’s staff is online, you information about the event. You can can request a live meeting and you will be choose to mute the ‘Live Host’ by clicking placed in a queue. You can always see your on the volume icon and you can move or position in the queue and when you reach minimize the ‘Live Host’ window as needed. the top of the queue a video meeting with the selected member of the exhibitor’s team JOINING A ZOOM WEBINAR SESSION will begin. (FOR PRESENTERS) ORAL AND POSTER PRESENTATION When joining a Zoom webinar session, GALLERY a window will appear asking you to use either your computer audio or connect In the ‘Oral and Poster Presentation to the audio via telephone (dial-in details Gallery’, you will be able to browse and are provided). If the webinar does not load search for presentations that interest you. or if you are having any technical issues Click on the presentation to find out more information and enter to view the recorded 30

GENERAL INFORMATION presentation. You can use the discussion EXPORTING YOUR NOTES AND forum, download presenter handouts and CONTACTS enter your own notes. Any notes that you take throughout the MUTING YOUR CAMERA AND event as well as any contact details from MICROPHONE your Meeting Hub connections can be exported by selecting the ‘Export’ icon in When using the Meeting Hub, Live Support the top right corner of your screen near or Exhibitor Instant Meetings, your camera your Profile image. and microphone will be enabled by default once the Video Call starts. Click on the HAVING CAMERA OR MICROPHONE icons in the video window to disable the PROBLEMS? camera and mute your microphone as needed. Please reset or review your browser permissions for your camera and microphone. For example, in Chrome, you can click on the small lock icon to the right of the platform URL to check on these settings. Insight meets 5/25/22 2:20 PM action at the point of possibility. 31 Getting the most out of your robotics program—that’s Intuitive Learn more at intuitive.com Important safety information For Important Safety Information, indications for use, risks, full cautions and warnings, please refer to www.intuitive.com/safety © 2022 Intuitive Surgical Operations, Inc. All Rights Reserved. PN1097904-US RevB 05/2002 PN1097904-rB_APoP_DataViz_7-5x4in_R1.indd 1

2RIME0PPOA2CR1TT This report is a summary of our work in 2021 and what we have achieved as a national health technology assessment (HTA) organisation. Thank you to everybody who collaborated with us in 2021 and enabled us to continue supporting the health and care sectors in Wales. 88 9 6 49 Topics proposed to Health Evidence appraisals Pieces of national guidance Topic exploration Technology Wales published published reports produced 188,680 individuals will be “HTW’s delivery has been really impressive.“ Types of recommendation made impacted in Wales if HTW HTW has remained absolutely focussed “ in HTW guidance in 2021 guidance published since on its core purpose, delivering a rapid streamlined approach to the identification, 1177%% 2017 is implemented. appraisal and adoption of health and care 883%3% New economic analysis to technologies in Wales. This and the open assess cost effectiveness in call methodology has ensured really strong Routine adoption Insufficient evidence to adopt Wales was undertaken for 5 stakeholder relationships, and agile delivery, pieces of national guidance particularly in response to the pandemic, in 2021 where HTW made an important contribution. Ifan Evans, former Director - Technology, Digital & Transformation, Welsh Government Better Health | Evidence Driven Advisory committee In 2021 we established a collaborative meetings hosted: partnership with Social Care Wales and published our first 5 Appraisal panels piece of social care guidance on START - a support programme for carers of people with dementia. 10 Assessment groups “Over the last year we’ve Throughout 2021 we worked with 3 Executive groups global partners to create position 3 Industry user groups continued to work closely with the statements for the International 4 Patient and public team at Health Technology Wales. It’s been – and continues to be – a true collaboration, Network of Agencies for Health involvement (PPI) and we’re looking forward to our future work Technology Assessment (INAHTA). standing groups to promote and embed the practice of health HTW was also awarded the Website technology assessment in social care in David Hailey Award for Best Impact Wales. Story at the INAHTA 2021 Congress. 53,118 Webpage views 15,673 Unique visitors Lisa Trigg, Assistant Director of Research Data and Intelligence, Social Care Wales In March 2021 HTW was appointed a Collaborating Partner of the Wales COVID-19 Evidence Centre (WCEC) WCEC COLLABORATING PARTNERS www.healthtechnology.wales Health Technology Wales @HealthTechWales Annual Report 2021 [email protected] 32

Schedule-at-a- Glance

SCHEDULE-AT-A-GLANCE SScchheedduullee--aAt-ta--AG-Glalnacnece HTAi Business Meetings Social Events Ceremonies Workshops Panels Plenaries Exclusive Symposia Oral Sessions Saturday 25 June Sunday 26 June Monday 27 June Tuesday 28 June Wednesday 29 June Opening Ceremony Plenary 2 08:00 Pre-Conference 08:00-08:40 08:10-09:25 David Banta Tribute & Workshop Keynote Award Presentation 09:00 Pre-Conference 08:30-10:00 08:40 - 09:00 Special Session 08:45-09:15 Workshop Plenary 1 09:25-09:40 Panels 5 08:30-10:00 09:00-10:15 Oral 3 09:25-10:40 09:50-11:05 10:00 Refreshment Break Refreshment Break Refreshment Break Refreshment Break 11:00 10:00-10:30 10:00-10:30 & Posters 1 10:15-10:45 Refreshment Break 10:40-11:10 Exclusive Symposium & Posters 6 11:05-11:35 Plenary 3 Pre-Conference Pre-Conference 10:45-12:00 Panels 3 11:10-12:45 Workshop Workshop 11:35-12:50 10:30-12:00 10:30-12:00 Oral 1 12:10-13:10 12:00 Lunch Lunch 12:00-13:00 12:00-13:00 13:00 Pre-Conference Pre-Conference Lunch / Posters 7,8,9 / Closing Ceremony Workshop Workshop Sponsored Symposia / IG 12:45-14:00 13:00-14:30 13:00-14:30 Meetings Lunch / Posters 2,3,4 / 12:55-13:55 14:00 Refreshment Break Sponsored Symposia / IG 14:30-15:00 Meetings 13:15-14:15 Oral 4 Pre-Conference 14:00-15:00 Workshop Panels 1 Refreshment Break 15:00-16:30 14:20-15:35 14:30-15:00 15:00 Exclusive Symposium Pre-Conference 15:10-16:25 Workshop 15:00-16:30 16:00 Oral 2 15:45-16:45 17:00 Refreshment Break & Refreshment Break & 18:00 Posters 5 16:45-17:15 Posters 10 16:25-16:55 19:00 Panels 2 Panels 4 17:15-18:30 16:55-18:10 Welcome Reception IG Meetings 18:30-22:00 18:15-19:15 Annual General Meeting Conference Dinner 19:00-20:00 19:30-00:00 Please note that times may be subject to change. 34

Program Agenda

PROGRAM AGENDA Program Agenda Saturday, June 25, 2022 Time (UTC) Item Room 08:30 – 16:30 HTAi Board of Directors Meeting (Invitation Only) 116 08:30 – 10:00 Workshops: • Advanced Workshop In Information Retrieval: Addressing 114 10:00 – 10:30 10:30 – 12:00 Lifecycles Of The Literature In Health Technology 117 12:00 – 13:00 Assessment 13:00 – 14:30 215 • How To Incorporate Environmental Impact To Quality Of 14:30 – 15:00 Care And Guidelines 315 15:00 – 16:30 1st Floor • How To Perform A Trial-Based Economic Evaluation Using Foyer R Various 1st Floor • HTA 101: Introduction To Health Technology Assessment Foyer Morning Break 114 Continuation of the Workshops Lunch (Workshop attendees only) 117 Workshops: 215 • Advanced Workshop In Information Retrieval: Addressing 315 Lifecycles Of The Literature In Health Technology Assessment (Cont.) 417 • Integrating Patient And Citizen Perspectives: Resources And Challenges For A Lifecycle Approach 1st Floor • Lifecycle Approach To Regulatory, Management And Foyer Assessment Of Health Technologies: Is It The Solution For Various Resource Constraint Settings? • An Interactive Workshop On The Theory And Practice Of Measuring The Impact Of Health Technology Assessment • Generating And Using Real World Evidence For Health Technology Assessment Afternoon Break Continuation of the Workshops 36

PROGRAM AGENDA Sunday, June 26, 2022 Time (UTC) Item Room 110 08:30 – 10:00 Workshops: • Early Awareness And Alert Systems (EAA) On New, Emerging And Obsolete Technologies 09:00 – • HTA 102. Hospital-Based HTA 114 12:00 117 10:00 – 10:30 • Values In Doing Assessments Of Healthcare 10:30 – 12:00 Technologies (VALIDATE) 215 12:00 – 13:00 13:00 – 15:30 • An Introduction To Early Health Technology 315 13:00 – 14:30 Assessment 417 14:30 – 15:00 • Research Oriented Market Access for Adopting High- 15:00 – 16:30 Cost Therapies –Principles and Practice 1st Floor Foyer 16:30 – 17:30 Various 18:30 – 22:00 Global Policy Forum Business and Topic Scoping 1st Floor Foyer Meeting (Invitation Only) 417 Morning Break 110 Continuation of the Workshops 114 117 Lunch (Workshop attendees only) 215 EuroScan Meeting (Invitation only) 315 Workshops: 1st Floor Foyer • Introduction to Ethics in Health Technology Various Assessment 417 • HTA 102. Hospital-Based HTA (Cont.) Mies Bouwman Foyer, Beatrix • The Use Of Evidence-Informed Deliberative Processes Building For Health Technology Assessment In Low- and Middle-Income Countries • Reducing The Computational Burden Of Health Economic Models And Analyses Using Metamodeling • Exploring Methods for Evaluating Impact of Patient and Public Involvement in the Assessment of Technologies Along their Lifecycle Afternoon Break Continuation of the Workshops HTAi Scientific Development and Capacity Building Committee Meeting Welcome Reception 37

PROGRAM AGENDA Monday, June 27, 2022 Time (UTC) Item Room 08:00 – 09:00 Welcome Ceremony Beatrix 09:00 - 10:15 • Keynote Address, Prof. Marcel Levi, Chairman, Theatre 10:15 – 10:45 10:45 – 12:00 Netherlands Organization for Scientific Research (NOW), Beatrix 12:10 – 13:10 The Netherlands Theatre Plenary Session 1 - Adopting a Lifecycle Approach in 13:15 – 14:15 HTA: Consequences for Priority-Setting and International Expo Hall Collaboration Mies Morning Break Bouwman Poster Presentations Beatrix Theatre Exclusive Symposium - You Better Believe It: Methodologies To Address Concerns In Using Real-World Evidence For 114 Measures Of Treatment Effectiveness (F-Hoffman-La Roche 117 Ltd) 215 Oral Presentation Session 1: 315 • OS01 Discrete Choice Experiments (DCE) Beatrix • OS02 Early HTA Theatre • OS03 Economic Evaluation 417 • OS04 European Collaboration Virtual • OS05 Patient and Clinician Involvement Expo Hall Mies • OS06 Systematic Reviews for HTA Bouwman • OS07 Quality of Evidence Lunch 215 Poster Presentations 315 417 HTAi Interest Group Meetings (HTAi Members Only): • Real World Evidence & Artificial Intelligence • Medical Devices • Hospital Based HTA (continued on next page) 38

PROGRAM AGENDA (Monday, June 27, 2022 continued) Time (UTC) Item Room 13:15 – 14:15 14:20 – 15:35 Symposia: 16:45 – 17:15 • Making Gene and Cell Therapies Reality for Patients: How 114 HTA and Novel Payment Solutions Play a Central Role (F-Hoffman-La Roche Ltd) • What does ‘Value’ mean in Cancer Policy & Practice? 117 Interventions for Improved Patient Outcomes across Geographies (Merck & Co., Inc.) Panel Presentation Session 1: • PN01 Building Bridges Between Patient And Treatment 114 - Perspectives On Harmonizing Health Technology Assessment With Up And Down-Stream Stakeholders • PN02 Health Technology Assessment in Situations of 117 Uncertainty: The Case of COVID-19 Technologies • PN03 The Year Of Change: From National To European 417 Health Technology Assessment Procedures • PN04 Horizon Scanning for New and Emerging 315 Technologies. Experiences Along the World., So Similar, So Different • PN05 Developing HTA in the Balkans – A Roadmap for Virtual Success with International Collaboration • PN06 A Lifecycle Approach to Promote Engagement Beatrix and Efficiency in HTA: 2022 HTAi Global Policy Forum Theatre Summary • PN07 Working Together In Health Technology Assessment Virtual On Oncology Immunotherapy Lifecycle: Opportunities And Challenges In East Asia • PN11 Can Social Media Research help to improve public 215 confidence in Health Technology Assessment (HTA) and healthcare decision making? Afternoon Break Expo Hall Poster Presentations Mies Bouwman (continued on next page) 39

PROGRAM AGENDA (Monday, June 27, 2022 continued) Time (UTC) Item Room 15:45 – 16:45 Oral Presentation Session 2: 17:15 – 18:30 • OS09 HTA in World 114 • OS10 Artificial Intelligence 117 19:00 – 20:00 • OS11 Horizon Scanning Beatrix Theatre • OS12 Lifecycle 315 • OS13 Pricing 417 • OS14 Real World Data – Use Virtual • OS15 Diabetes Virtual • OS16 Multi-Stakeholder Involvement 215 Panel Presentation Session 2: • PN09 The International Horizon Scanning Initiative: 114 Empowering Governments to Identify and Negotiate Fair Prices Virtual for Innovative Health Technologies • PN10 From Thought to Action: Legitimate Decision Making and 215 The Role of Stakeholders in the HTA Processes • PN11 Can Social Media Research Help to Improve Public 315 Confidence in Health Technology Assessment (HTA) and Healthcare Decision Making? 417 • PN12 Would the Novel Elements of Value Contribute to Equitable Access to New Medical Technologies? – A Multi- Beatrix stakeholder perspective. Theatre • PN13 Deep Dive on Uncertainty – A Multistakeholder 117 Discussion Hosted by the HTAi-DIA Joint Working Group • PN14 Deliberative Processes for Informed Decision – Making Virtual by Health Technology Assessment: HTAi Latin America Policy Beatrix Forum 2021 Findings Theatre • PN15 Patient and Public Participation in Health Technology Assessment’s Organizational Domain: Approaches and Opportunities • PN16 Impact of Health Policies on HTA Annual General Meeting (HTAi Members Only) 40

PROGRAM AGENDA Tuesday, June 28, 2022 Time (UTC) Item Room 08:10 – 09:25 Beatrix 09:25 – 09:35 Plenary Session 2 - Public Confidence in Healthcare Theatre 09:50 – 11:05 Decision-Making Beatrix Theatre 11:05 – 11:35 Special Session - HTA in Challenging Times: Experience in 11:35 – 12:55 Ukraine 114 117 Oral Presentation Session 3: 215 Beatrix • OS17 Children and Paediatrics Theatre 417 • OS18 Horizon Scanning Virtual Virtual • OS19 Guidance for HTA 315 Expo Hall • OS20 Patient Perspectives Mies Bouwman • OS21 Treatment Value Virtual • OS22 HTA Tools 117 • OS23 COVID 215 • OS24 Environmental Impact 315 Morning Break 417 Poster Presentations 114 Panel Presentation Session 3: • PN17 Fit For Purpose Novel Payment Models to Increase Patient Access to Cell and Gene Therapies: Let’s Work Together • PN18 Real-world Evidence’s Role in Lifecycle Management: Learnings from ICER and NICE’s Demonstration Projects • PN19 Journal Submissions - Some Useful Tips For Success • PN20 Developing A Multi-Stakeholder Shared Learning Platform To Improve Understanding In The Use And Acceptance Of RWE • PN21 Joint Scientific Consultations: How Will the Present Inform the Future? • PN22 The Added Value Of A Value-Oriented Perspective In Health Technology Assessment (continued on next page) 41

PROGRAM AGENDA (Tuesday, June 28, 2022 continued) Time (UTC) Item Room 11:35 – 12:55 Panel Presentation Session 3 continued: • PN23 A Lifecycle Approach in Assessing Digital Beatrix 12:55 – 13:55 Theatre Applications: in Silos or Teaming up Internationally? Virtual • PN24 Applying Patient Preferences in HTA: Do Expo Hall Preferences and Can Preferences Influence HTA Decision Mies Making? Bouwman Lunch Poster Presentations HTAi Interest Group Meetings (HTAi Members Only) • Ethics 315 • Patient and Citizen Involvement 215 • Public Health 417 IJTAHC Editorial Board Meeting (Invitation Only) 110 Symposium 14:00 – 15:00 • Facilitating RWE Use In HTA: Creating A Taxonomy 114 For Problem Solving And Data Legitimization (Novartis Pharma AG) Beatrix Theatre Oral Presentation Session 4: 117 215 • OS25 Patient Involvement 315 417 15:10 – 16:25 • OS26 Decision Making 114 Virtual • OS27 Virtual Beatrix Theatre • OS28 Real World Data – Impact • OS29 PROMS • OS30 Stakeholder Engagement • OS32 Priority Setting Exclusive Symposium – Capacity-Enhancing Innovations as Enablers for Resilient Healthcare Systems (Edwards Lifesciences) (continued on next page) 42

PROGRAM AGENDA (Tuesday, June 28, 2022 continued) Time (UTC) Item Room 16:25 – 16:55 Expo Hall 16:55 – 18:10 Afternoon Break Mies Bouwman 18:15 – 19:15 Poster Presentations 19:30 – 23:59 114 Panel Presentation Session 4: Virtual • PN25 Enhancing ‘Public Confidence in Healthcare Decision-Making’ in Low-and Middle-Income Countries 215 through Stakeholder- and Context-Conscious Health Technology Assessment (HTA) 315 417 • PN26 How May the Lifecycle Approach Feed into HTA Capacity Building Strategies in Low- and Middle- Beatrix Income Countries (LMICs)? Theatre Virtual • PN27 Sustainable Modeling: Taking A Lifecycle Approach To Model Development To Increase 117 Assessment Efficiency And Validity 215 • PN28 EU HTA Regulation: Improved Access or Layering 315 of Processes? 417 • PN29 Patient Registries Providing Real-World Evidence Railway Museum, to Support a Lifecycle Approach for HTA of Expensive Malibaanstation Drugs, from Different Perspectives. 16, 3581 XW • PN30 HTA in Asia Post-COVID-19: HTAi Asia Policy Forum 2021 Findings • PN31 Regulatory and Health Technology Assessment Alignment: A Match Made in Heaven or Irreconcilable Differences? • PN32 Do Differences In HTA Deliberative Structures Affect Confidence In The Outputs? A Discussion And Proposed Research Agenda HTAi Interest Group Meetings (HTAi Members Only) • HTA in Developing Countries • Information Retrieval • Disinvestment and Early Awareness Conference Dinner (Ticket purchase necessary) 43

PROGRAM AGENDA Wednesday, June 29, 2022 Time (UTC) Item Room 08:45 – 09:15 09:25 – 10:40 David Banta Tribute and Award Presentation Beatrix Theatre 10:40 – 11:10 11:10 – 12:45 Panel Presentation Session 5: 12:45 – 14:00 • PN33 Patient Involvement in Health Technology 315 Assessment (HTA) – Are We All on the Same Page? • PN34 Creating Political, Societal and Professional Support Beatrix for Sustainable Healthcare Choices Theatre • PN35 Qualitative Evidence: A Methodology That Can Guide 417 Lifecycle Health Technology Assessment • PN36 Beyond Checking The Boxes: Guidance Of The Joint 114 HTAi – ISPOR Task Force Deliberative Processes For HTA • PN37 Collaboration to Overcome Challenges in 117 Generation and Interpretation of Evidence for Rare Disease Treatments • PN38 Outcome-Based Reimbursement and Delayed- 215 Payment Schemes for New Technologies Central and Eastern European and Middle-Eastern Countries • PN39 A Lifecycle Approach to HTA: The Role of Virtual Implementation Alongside Economic Evaluation • PN40 Value From a Multi-stakeholder Perspective: An Virtual Assessment Framework for Digital Health Solutions to Improve Chronic Disease Management Morning Break Expo Hall Plenary Session 3 - Running Around in Circles; Time for Real Beatrix Collaboration between Regulators, HTA Bodies and Clinicians Theatre Closing Ceremony and Award Presentations Beatrix Theatre 44

Feature Sessions

FEATURE SESSIONS Feature Sessions Sunday, June 26 Monday, June 27 Welcome Reception Welcome Ceremony and Keynote Address In-Person: 18:30 – 22:00 Mies Bouwman Foyer 08:00 – 09:00, Beatrix Beatrix Building, Utrecht Theatre (Ground Floor) Virtual: 18:45 – 21:00 • Welcome address on behalf of the host Virtual Meeting Platform organizations, Dr. Sjaak Wijma, National & Mobile Conference App Health Care Institute Netherlands Join us in welcoming colleagues and friends • O pening address from the Netherlands from around the world to the HTAi 2022 Director of Medicine, Karla van Rooijen, Hybrid Annual Meeting. Enjoy some special Ministry of Health, the Netherlands entertainment and receive a warm welcome from our local hosts both live in Utrecht and • W elcome address on behalf of HTAi, streamed to the virtual meeting platform. Dr. Wija Oortwijn , HTAi President, the There will be plenty of time to network with Netherlands international attendees and start engaging conversations to revisit throughout the • W elcome address on behalf of the HTAi Annual Meeting. 2022 ISPC, Dr. Wim Goettsch, Ann Single, and Professor Gert Jan van der Wilt • K eynote presentation, Prof. Marcel Levi Prof. Marcel Levi Chairman, Netherlands Organization for Scientific Research (NWO), The Netherlands Prof. Marcel Levi is an Internist and, since April 2021, the Chairman of the Netherlands Organization for Scientific Research (NWO) and Professor of Medicine at Amsterdam UMC and University College London. He was previously Chief Executive of University College London Hospitals and Chairman of the Board of Directors of the AMC. He previously worked in Perugia, Oxford, New York, and Leuven. He has published over 750 scientific articles and is a member of the Royal Academy of Sciences and an honorary fellow of 46

FEATURE SESSIONS the Royal College of Physicians. He holds health system’s perspective will be needed. board positions in national and international Consistent consideration of the lifecycle will organizations in the fields of healthcare, change the way research and policy interact research, and education/training. and inform each other and affect the tasks of HTA agencies, both quantitatively and Monday, June 27 qualitatively. Diversification of methods will be needed, as well as a re-thinking of what Plenary 1 constitute relevant data and how these may be obtained (e.g., is organizing continuous 09:00 – 10:15, Beatrix Theatre data collection combined with AI-supported (Ground Floor) analysis the key?). Appropriate scientific development and capacity building will Adopting a Lifecycle Approach be required and, because of an increased in HTA: Consequences workload for HTA agencies, setting for Priority-Setting and priorities and international collaboration International Collaboration and coordination will be needed more urgently. What could be the best path to HTA has recently been defined as follow winding through these challenges and opportunities associated with the “a multidisciplinary process that adoption of lifecycle approach in HTA? Do uses explicit methods to determine adequate priority-setting and international the value of a health technology at collaboration and coordination help? This different points in its lifecycle. The plenary will try to find out. purpose is to inform decision-making in order to promote an equitable, MODERATORS efficient, and high-quality health system” (O’Rourke, Oortwijn and Alric Rüther Schuller, Int J Technol Assess Health Head International Affairs Care 2020; 36: 187 – 190). Institute For Quality And Efficiency In Health Care Adopting such a lifecycle approach in HTA (IQWIG), Germany has a number of potentially far-reaching consequences. Rather than a one-off Alric Rüther is a physician exercise to critically appraise and synthesize trained in Internal the best available evidence to support Medicine and Oncology. Based on his market access and coverage decisions, it engagement in Evidence Based Medicine involves several tasks and requirements and Cochrane Collaboration, he worked which continuously need attention. Central, to establish and build the discipline of but not exclusive, is the careful monitoring HTA in Germany. Alric is founder of the of novel technological developments, the German Agency for HTA (DAHTA) at DIMDI anticipation of their potential impact, and of the Federal Ministry of Health. In 2007, keeping track of their evolution, especially Alric moved to the Institute of Quality in terms of gaining or losing value as and Efficiency in Health Care (IQWiG), the result of (parallel) technological, heading the Department of Health Care epidemiological, economic, organizational Quality. His main task of the department and cultural developments. Hence, rather was to identify and describe Health Care than focusing on individual technologies, a Standards based on Clinical Practice Guidelines, such as scientific background for Disease Management Programs (DMP). 47

FEATURE SESSIONS Additionally, Alric was responsible for the Dr. Pauline Evers development and maintenance of the Patient advocate at international relationships of IQWiG. This the Dutch Federation led to the establishment of the Department of Cancer Patient of International Affairs at IQWiG in 2015, Organizations, Member of which Alric is leading now. Alric has been the Committee for Orphan engaged in worldwide HTA development Medicinal Products for more than 10 years: with HTAi since its at the European Medicines Agency, the founding (Board member since 2013; Chair Netherlands of Annual Meeting Committee from 2016 to 2017; Chair of Scientific Development After studying medical biology at the and Capacity Building Advisory Committee University of Groningen, The Netherlands since from 2017 to 2020); INAHTA (1983), Dr. Evers conducted her Ph.D. in (Vice Chair until 2006; Chair of internal Anthropogenetics at the Free University of communications from 2005 to 2016); Amsterdam (1988). She worked for 15 years EUnetHTA (founding member; Chair of in the pharmaceutical industry, mainly in plenary from 2010 to 2012; Lead Partner regulatory affairs. Quality Management, Scientific Guidance and Tools [WP6] Joint Action 3 from 2016, Since 2003 she has worked for various Co-Chair of the Consortium of EUnetHTA21 patient organizations, first in the rare from 2021); and ISPOR (Chair of HTA disease area at the VSOP (the Dutch roundtable Europe from 2013 to 2016). umbrella organization for rare and Alric is also an associate professor at the inheritable diseases) and ENMC (European University of Bielefeld and Berlin, lecturing NeuroMuscular Centre) and since 2008 HTA. at the Dutch Federation of Cancer patient organizations (N.F.K.). Her advocacy SPEAKERS activities are in medicinal products, research, and reimbursement. Dr. Jaap Deinum Medical Specialist Internal Since May 2006, she has been one of Medicine, Department the three patient representatives on the of Internal Medicine, Committee for Orphan Medicinal Products Radboud University (COMP) at the European Medicines Agency Medical Centre, the (E.M.A.). Netherlands Dr. Janneke Grutters Dr. Deinum is an internist, with a focus Associate Assistant on vascular medicine. He was trained in Professor, Departments Rotterdam (Erasmus MC), the Netherlands of Health Evidence and registered in 1995. Since 2002, he has and Operating Theater, been a staff member at the department of Radboud University Medicine at RadboudUMC, Nijmegen, the Medical Centre, the Netherlands Netherlands Dr. Janneke Grutters works as an associate professor at the Health Evidence and Operating Rooms department at Radboudumc, Nijmegen, the Netherlands. She holds an MSc in health sciences and a 48

FEATURE SESSIONS Ph.D. in Health, Medicine and Life Sciences and Information Unit at MaHTAS until 2020. from Maastricht University. Dr. Izzuna is actively involved at local and international level. She is a visiting lecturer Her key research interest lies in the early at University of Malaya, University of evaluation of innovations in healthcare. By Science Malaysia and Cyberjaya University. assessing the (potential) value of innovation She is also member of various committees in the early stages of its development, she at national level including Cluster of aims to contribute to more accountable Emerging Technologies, Nutritional decisions regarding the development, Research, National Technology Innovation research, and use of these innovations, Sandbox and National Rare Disease leading to more efficient use of resources Committee. At international level, she is and better healthcare. Learning from other currently the Vice President of HTAsiaLink, fields of research, she develops and uses Regional Coordinator for AsiaScan, the methodology that enables such an early regional group for Asia Pacific region of the evaluation and acknowledges all relevant International Health TechScan (i-HTS) and uncertainties. a member of the organising committee for HTAi Asia Policy Forum. She has also Since 2015 she has been awarded a junior published several articles on public health Principal Investigator predicate from matters and health technology assessment. Radboudumc for scientific excellence and is a member of several committees of the Dr. Susan Myles National Health Care Institute (Zorginstituut Director, Health Nederland) and the Netherlands Technology Wales, United Organisation for Health Research and Kingdom Development (ZonMw). Susan Myles is Director of Dr. Izzuna Mudla Health Technology Wales Mohamed Ghazali (HTW) a national HTA body established Deputy Director, Malaysian to deliver a strategic approach to the Health Technology identification, appraisal, and adoption of Assessment Section medical technologies in Wales (UK). HTW (MaHTAS), Ministry of produces rapid evidence reviews and Health Malaysia, Malaysia national guidance on the use of medical technologies in health and care settings Dr. Izzuna Mudla Mohamed Ghazali is the in Wales. Susan has been engaged in Deputy Director of Medical Development applied health technology assessment for Division, Ministry of Health Malaysia and 25 years. Prior to joining HTW, she led the the Head of Malaysian Health Technology establishment and work of the Scottish Assessment Section (MaHTAS). She is a Health Technologies Group (SHTG). Public Health Physician and joined MaHTAS in 2007. Since then, she has been involved Susan holds qualifications in Economics in planning and implementation of health (BA, Strathclyde) Health Economics (MSc, technology assessment, development York) Epidemiology (PgDip, Edinburgh) and and implementation of clinical practice Health Services Research (PhD, Edinburgh). guidelines, and was given the responsibility She has held lectureships and research to set up horizon scanning of emerging positions in health economics and received health technologies activity for Ministry of scholarships from the UK Department of Health Malaysia in 2013. She became the Health and Medical Research Council. Head of Horizon Scanning, Communication Susan is also a previous recipient of a 49

FEATURE SESSIONS Harkness Fellowship in Healthcare Policy, Markus joined St. Jude Medical in January based at Johns Hopkins University in the 2004 after almost seven years at Eucomed USA. Her interests span several areas of (now MedTech Europe), where he headed health economics and health services the Economic Affairs Department. research. He holds a Master’s Degree in Economics Mr. Markus Siebert from the University of Bochum (Germany) Senior Director, Health and a Master’s in Health Economics from Economics and VLEKHO, Belgium. Reimbursement OUS, Abbott, Belgium Tuesday, June 28 Markus Siebert is the Plenary 2 Senior Director of Health Economics & Reimbursement of the 8:10 – 09:25, Beatrix Theatre (Ground Floor) International Division at St. Jude Medical (now Abbott) since January 2012. He is Public Confidence in responsible for the development and Healthcare Decision-Making execution of reimbursement strategies and for guiding the development of The legitimacy of healthcare decision- health economic evidence in support of making has never been so fiercely debated Market Access for Abbott’s medical device as in the COVID19 pandemic. The pandemic innovations in Europe, Latin America, Asia has highlighted significant differences and Australia. between public worldviews, including populations who are skeptical of science Markus works with multiple stakeholders, and distrust governments and health including payers and HTA agencies to systems. Within this climate, HTA depends establish and improve reimbursement for on public confidence for its funding and the Abbott’s innovations. He is also driving implementation of its recommendations internal initiatives on Early Value Assessment or advice. For its credibility and legitimacy, and Market Access for Digital Solutions. its processes should be seen as fair and transparent. But HTA is typically only seen Markus has held several positions at by a small subsection of the population MedTech Europe (previously Eucomed), the who have an interest in its assessments. European medical technology association. Even among the many stakeholders who He served as Chair of the Evidence & Payers may experience consequences from HTAs, Working Group and as Chair of Working the process may not be visible resulting in Groups on Economics and Telemonitoring. misunderstandings or distrust about whose He was a member of the Cardiovascular interests and values are being considered or Roundtable of the European Society of prioritized. Cardiology; and a company representative on the HTAi Policy Forum. Markus was Integrating stakeholders’ perspectives co-initiator and Board Member of EHTI, in HTA – either through evidence or the European Health Technology Institute participation – may play a role in improving for Socio-Economic Research and has co- public confidence in HTA by fostering authored several publications in the area of medical device market access. 50