Research and Development of Nutritional Cosmetic http://www.nadiecomomama.com/moda-y-belleza/belleza/nutricosmetica/ Sarita Sangthong, Ph.D. 1
Research and Development of Nutritional Cosmetic (R&D of NC) Contents 1. Overview and process of R&D 2. NC market research 3. The preformulation of NC product 2
Overview & Process of RD *Optional MANUFACTURING RESEARCH DEVELOPMENT 3
Overview & Process of R&D Define the claims of the NC product 4
Overview & Process of R&D Define the claims of the NC product By types By Application • Vitamins • Anti-aging Application • Antioxidants like • For Skin, Hair and Nails Care • Photo-Protective Nutrients • For Beauty • Omega-3 Fatty acid • For Weight Reduction • Biotin • For Energy Boosting • Amino acid complexes • Pro/ Prebiotics • Plant Based; Flavonoids, Carotinoids, Polyphenol https://www.linkedin.com/pulse/global-nutricosmetics-market-2016-industry-forecast-2020-richel-john/ 5
Overview & Process of R&D Dosage forms Raw materials and claims https://www.pinterest.com/pin/353251164506661794/ 6
Research and Development of Nutritional Cosmetic (R&D of NC) Contents 1. Overview and process of R&D 2. NC market research 3. The preformulation of NC product 7
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NC global market research Healthy Vision ≤ 3h./day 10-12 h./day 4-6 h./day 7-9h./day 9 https://www.pinterest.com/eyerecommend/healthy-eyes/
NC global market research Healthy Vision meg-3.com/en_US/news/omega3s-for-healthy-vision.html itamininbox.com/product/1774/nutrex-eyeastin-with-pure-natural-astaxanthin-60-softgels hyalogic.com/hyaluronic-acid-supplements/hylavision-eye-support-detail https://www.purityproducts.com/ 10 eye-health-supporting-nutritional- supplements/ultimate-eye-formula
NC global market research Healthy and Fitness Lifestyle https://www.pinterest.com/ highmark/fun-fit-and- fabulous/?lp=true 11
NC global market research Healthy and Fitness Lifestyle bandasfitnessworld.com/team- fitness-stacks.com/products/pump- bodybuilding-coms-favorite-supplements/ stack-pump-enhancer-supplement- non-stim-30-servings http://stylecaster.com/bodyskin- 12 carepopping-pills-get-beautiful- from-inside-out/slide6
NC global market research Aging society 13 http://www.strategyr.com/MarketResearch/Nutricosmetics_Market_Trends.asp
NC global market research Aging society THE HEALTHIEST, !THE LUCKIEST http://www.webmd.com/healthy-aging/nutrition-world-2/ slideshow-nutrition-longevity DeSimone & Heckman (2016). Nutrition market trends, An aging population: Industry opportunities, 14
NC global market research Aging society https://www.pinterest.co.uk/pin/557320522623381795/ https://organixx.com/7m-plus/ 15
Research and Development of Nutritional Cosmetic (R&D of NC) Contents 1. Overview and process of R&D 2. NC market research 3. The preformulation of NC product Oral administration Knows your ingredients 16
The preformulation of NC product To define the nature of active ingredients Allen (2008 )Clinical Therapeutics (30) 2102-2111 Active ingredient (s) NC product 17
The preformulation of NC product Route of administration Oral administration 18
The preformulation of NC product Pharmacodynamics & pharmacokinetics PD PK 19 https://www.symbiotics.com/category/symbiotics-life/
The preformulation of NC product Absorption Metabolism Gastrointestinal tract Liver ADME Distribution Elimination Blood stream and through Kidney cellular membrane Pharmacokinetic Site of action Pharmacodynamic Mechanism of action 20
The preformulation of NC product Ready to be absorbed ! Plain tablet You’ll see more type dosage forms in the next topic 21
The preformulation of NC product Absorption or jejunum or ileum Vitaliy V. Khutoryanskiy Nature Materials 14, 963–964 (2015) 22
The preformulation of NC product Absorption Basic drug Acidic drugs absorption also called Gastric 23 Pharmacology: Oral Meds Absorption, GABAY MEDICAL library (2008)
The preformulation of NC product Absorption (pH 1-2) Basic drug Acidic drugs absorption Unionized molecules 24 Pharmacology: Oral Meds Absorption, GABAY MEDICAL library (2008)
The preformulation of NC product Absorption Blood stream = Distribution Basic drug Liver 25 Pharmacology: Oral Meds Absorption, GABAY MEDICAL library (2008)
The preformulation of NC product Absorption Enterohepatic cycling 26 Pharmacology: Oral Meds Absorption, GABAY MEDICAL library (2008)
The preformulation of NC product Absorption Basic drug Acidic drugs absorption also called Gastric 27 Pharmacology: Oral Meds Absorption, GABAY MEDICAL library (2008)
The preformulation of NC product Absorption Basic drug 28 Pharmacology: Oral Meds Absorption, GABAY MEDICAL library (2008)
The preformulation of NC product Absorption 29
The preformulation of NC product Absorption 30 https://www.pinterest.com/pin/225813368793992923/
The preformulation of NC product Absorption and Distribution Cell membrane = Phospholipid bilayer 31
The preformulation of NC product https://www.thoughtco.com/examples-of-mixtures-608353 Knows your ingredients 32
The preformulation of NC product Active ingredient(s) • Pharmacological activities • Physical property • Chemical property • Bioavailability • Standardization https://draxe.com/basil-essential-oil/ 33
The preformulation of NC product Active ingredient : Pharmacological activities Net effect and Mechanism of action • The physiologic or biochemical processes within the body that are affected by a drug’s action, producing a given response. Segen's Medical Dictionary. © 2012 Farlex, Inc. • The means by which a drug exerts its effects on cells or tissues. It may have specific binding sites, receptor activation, enzymatic activity, or solubility. Medical Dictionary, © 2009 Farlex and Partners 34
The preformulation of NC product Active ingredient : Dose = The amount of a substance administered at one time EC50: Half maximum effective 100% Effective dose Toxic dose concentration Percentage of response by the giving dose The concentration of active ingredient giving 50% of its maximum response 50% TC50: Half maximum toxic EC50 TC50 concentration The concentration of active ingredient giving 50% of its maximum toxicity Dose 35 The Pharmacological Basis of Therapeutics\" 11th ed by Brunton et al. and Basic & Clinical Pharmacology\" 11th ed. By Katzung et al.
The preformulation of NC product Active ingredient : Pharmacological activities Where to find ? 36
The preformulation of NC product Active ingredient : Pharmacological activities 37
The preformulation of NC product Active ingredient : Pharmacological activities 38
The preformulation of NC product Active ingredient : Pharmacological activities 39
The preformulation of NC product Active ingredient(s) • Pharmacological activities • Physical property • Chemical property • Bioavailability • Standardization https://draxe.com/basil-essential-oil/ 40
The preformulation of NC product Active ingredient(s): physical and chemical property To determine the properties of sample Do we need to change the identity of sample? YES = NO = Chemical properties Physical properties Modified from (https://chem.libretexts.org/Core/Inorganic_Chemistry/Chemical_Reactions/Properties_of_Matter) 41
The preformulation of NC product Active ingredient(s): physical and chemical property Chemical property Physical property • Reactivity with other chemicals • Color • Toxicity • Shape • Coordination number • Volume • Flammability • Density • Acidity/Basicity and pH • Temperature • The heat of combustion • Melting/ Boiling point • Oxidation states • Viscosity • Chemical stability • Solubility 42
The preformulation of NC product Active ingredient(s) • Pharmacological activities • Physical property • Chemical property • Bioavailability • Standardization https://draxe.com/basil-essential-oil/ 43
The preformulation of NC product Active ingredient(s): Bioavailability • The degree to which a drug or other substance becomes available to the target tissue after administration. (Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, 7th Edition, 2003) • The physiologic availability of a given amount of a drug, as distinct from its chemical potency; proportion of the administered dose that is absorbed into the bloodstream. (Farlex Partner Medical Dictionary, Farlex 2012) • The degree of activity or amount of an administered drug or other substance that becomes available for activity in the target tissue. (Mosby's Medical Dictionary, 9th ed., 2009, Elsevier) 44
The preformulation of NC product Active ingredient(s): Bioavailability Lipinski Rule of Five Good bioavailability • Molecular weight < 500 Da • Log P <5 (Lipophillicity) • Hydrogen bond donors <5 (Sum of OH and NH) • Hydrogen bond acceptors < 10 (Sum of N and O) 45
The preformulation of NC product Active ingredient(s): Bioavailability Lipophillicity (Log P) Octanol phase Lipophillic Aqueous phase Hydrophillic Octanol-water partition coefficient 46
The preformulation of NC product Active ingredient(s): Bioavailability Lipophilicity Log P < 5 = Optimum soluble = Well absorbed 47
The preformulation of NC product Active ingredient(s): Bioavailability pH value Absorption of acids Absorption of bases https://basicmedicalkey.com/drug-absorption-basics-and-the-oral-route/ 48
The preformulation of NC product Active ingredient(s) • Pharmacological activities • Physical property • Chemical property • Bioavailability • Standardization https://draxe.com/basil-essential-oil/ 49
The preformulation of NC product Active ingredient(s): Standardization Advantage: Quality control Batch to batch consistency of efficacy Appearance Product stability 50
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