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Academia Longevidade Saudável K, Acosta M, Nelson JC. Pharmacokinetic › Double-blind randomized controlled trials evaluation of triiodothyronine supple- with no superior significant effects of T4-T3 mentation in children after modified versus T4 alone, but more patients prefer- Fontan procedure. Circulation. 2000 Mar ring T4/T3 than T4 alone 28;101(12):1423-9 › 162. Appelhof BC, Fliers E, Wekking › Double-blind, crossover, but not placebo-con- EM, Schene AH, Huyser J, Tijssen JG, trolled: Desiccated thyroid extract or T3/ Endert E, van Weert HC, Wiersinga WM. T4 associations compared with levothyro- Combined therapy with levothyroxine and xine treatments Double-blind randomized liothyronine in two ratios, compared with controlled trials with significant superior levothyroxine monotherapy in primary effects of T4-T3 versus T4 alone hypothyroidism: a double-blind, rando- mized, controlled clinical trial. J Clin › 159. Bunevicius R, Kazanavicius G, Zalinke- Endocrinol Metab. 2005 May;90(5):2666-74. vicius R, Prange AJ Jr. Effects of thyroxine (141 patients (18-70 yr old) with primary as compared with thyroxine plus triiodo- autoimmune hypothyroidism: 52.2% -thyronine in patients with hypothyroi- and 41.3% patients preferred the T3-T4 dism. N Engl J Med. 1999 Feb 11;340(6):424-9. combinations (in T4:T3 ratios of 5:1 and Institute of Endocrinology, Kaunas Medical 10:1 respectively) compared to 29.2% for University, Lithuania. T4 alone treatment) › 160. Hoang TD, Olsen CH, Mai VQ, Clyde › 163. Saravanan P, Simmons DJ, Greenwood PW, Shakir MK. Desiccated thyroid extract R, Peters TJ, Dayan CM. Partial substitution compared with levothyroxine in the of thyroxine (T4) with tri-iodothyronine in treatment of hypothyroidism: a rando- patients on T4 replacement therapy: results mized, double-blind, crossover study. J Clin of a large community-based randomized Endocrinol Metab. 2013 May;98(5):1982-90 (A controlled trial. J Clin Endocrinol Metab. Patients (n = 70, age 18-65 years) diagnosed 2005 Feb;90(2):805-12. University of Bristol, with primary hypothyroidism, at the end Whitson Street, Bristol BS1 3NY, UK.( 697 of the study, 34 patients (48.6%) preferred hypothyroid patients, a subgroup of patients desiccated thyroid extract (DTE), 13 (18.6%) showing transient improvement after preferred L-T₄, and 23 (32.9%) had no prefe- partial substitution with T(3)) rence.) › Non-randomized controlled trials with no › Double-blind randomized controlled study superior significant effects of T4-T3 versus with near significantly superior effects of T4 alone, but more patients preferring T4/ T4-T3 versus T4 alone T3 than T4 alone › 161. Bunevicius R, Jakubonien N, Jurkevicius › 164. Escobar-Morreale HF, Botella-Carretero R, Cernicat J, Lasas L, Prange AJ. Thyroxine JI, Gomez-Bueno M, Galan JM, Barrios V, vs thyroxine plus triiodothyronine in Sancho J. Thyroid hormone replacement treatment of hypothyroidism after thyroi- therapy in primary hypothyroidism: a dectomy for Graves’ disease. Endocrine. 2002 randomized trial comparing L-thyroxine Jul;18(2):129-33 (no significant differences plus liothyronine with L-thyroxine alone. were found on measures of mood, cognition, Ann Intern Med. 2005 Mar 15;142(6):412-24. or physiologic variables between treatments, (28 women with overt primary hypothyroi- but symptoms of hypothyroidism and of dism (18/26 patients preferred the T3-T4 hyperthyroidism tended to decrease on a combinations, 2/26 the T4 alone treatment; standard symptom scale after combined open trial) treatment, mental state tended to improve on some mood scales) › Double-blind randomized controlled trial with no superior significant effects of T4-T3 165

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