Recipe for Life

Birthdays - December 26They are worriers and often suffer fromworrier's ailments: headaches, backaches,upset stomach, and sleeping disorders. ACapricorn born on December 26 possesses adetermined, serious nature. They can readthe motives of others and are good judges ofcharacter. These ambitious, career-orientedpeople have a pragmatic nature yet dreamlarge. They possess a generous soul and thedesire to be part of the crowd but may beunwilling to show these aspects of theirpersonality.217 **********************************************Dick Knight - James Holtgrieve - RyanHowison Birthdays - December 27They follow a restricted diet and get enoughexercise. They have somewhat old-fashionedideas about what kind of exercise is mosthelpful. They elevate style to an art yet arepractical and down to earth. When theyachieve their aims, it's the result of hard work.Their authoritarian nature makes them goodat handling others, particularly in theworkplace. They are demanding and have aperfectionist streak and can, at times, seemintolerant of others' mistakes.217 **********************************************William F. Eggers - Sophie Gustafson -Sherri Steinhauer Birthdays - December 28They can eat almost anything and usually do;their diet is varied and interesting. They oftenare talented cooks who can prepare exoticforeign food. A Capricorn born on December28 has a style all their own. Self-possessedand intelligent, they have great social skills,including the ability to make anyone feel athome. They take pride and enjoyment inperforming everyday tasks, believing it isthrough the minor events that character isformed and tested.217 **********************************************Martin Kaymer - Johnny Goodman - HubertGreen - Richard Backwell - Curt Allen Byrum Johnny Goodman: The Last Amateur Golfer to Win the United States Open by Walter J. Curtis: This book tells the compelling story of a poor orphaned kid growing up in the depression, who, against all odds, became an accomplished golfer. Johnny Goodman made golf headlines in 1929 by defeating Bobby Jones in the first round of the National Amateur. Goodman travelled from his home in Nebraska to the National Amateur, played at Pebble Beach that year, in a rail car full of cattle. However, the pinnacle of his career would come in 1933 with a victory at the U. S. Open. Still an amateur, Goodman defeated a strong professional field, including the likes of Walter Hagen. Goodman's 1933 U. S. Open win marks the last time an amateur has won that event.219 251

===========================oOo========================== Fatigue seems to be a serious problem for persons Marjoram with Marfan syndrome and seems related to some MIO Smoothie Ingredient areas of cognitive------------------------------------------------------------------------------------------------- functioning. We found no overall impairment in Sweet marjoram, also known as cognitive functioning, but knotted marjoram, is one of the slightly reduced speed of most popular Mediterranean information processing. herbs used for its culinary and Reduced visuo-motor medicinal values since ancient coordination could be times. The herb has delicate explained by impaired visual sweet flavor and mildly pungent acuity.156 (spicy) taste comparatively milder than oregano. Sweet ===================== marjoram is native to Asia minor NAD Fact Sheet (Turkey) but grown in plentiful all over Mediterranean and -------------------------------------southern Europe. NAD+ plays important rolesThe herb contains many notable phyto-nutrients, minerals and vitamins that in various biologicalare essential for optimum health and wellness. The herb parts contain processes. It has beencertain chemical constituents like eugenol sabinene, a -terpinene, cymene, shown that NAD+ treatmentterpinolene, linalool, cis-sabinene hydrate, linalyl acetate, terpinen-4-ol and can decrease genotoxicterpineol. These compounds are known to have anti-inflammatory and agent-induced death ofanti-bacterial properties. primary neuronal and astrocyte cultures, andMarjoram herb contains exceptionally high levels of beta-carotene, vitamin NAD+ administration canA, cryptoxanthin, lutein and zea-xanthin. Carotenes, xanthins and lutein are reduce ischemic brainpowerful flavonoid anti-oxidants. Together, these compounds help act as damage 157protective scavengers against oxygen-derived free radicals and reactiveoxygen species (ROS) that play a role in aging and various diseaseprocess.Zeaxanthin, an important dietary carotenoid, selectively absorbed into theretinal macula lutea in the eyes where it is thought to provide antioxidantand protective light-filtering functions. It has proven beneficial action againstage related macular disease (ARMD) especially in the elderly.436; 437; 438===========================oOo========================== 1986 Masters Champions Dinner Wiener Schnitzel Bernhard Langer------------------------------------------------------------------------------------------------- One of my favorite golfers, Bernhard Langer, was doing something he’s very familiar with… winning. His flawless swing isn’t the only reason I’ve always been such a fan of this brilliant German golfer. He’s a class act. He’s a winner. He doesn’t seem to have a malicious, proud, or arrogant bone in his body. He has workedhard to get where he is and is a perfect example that, with all due respect,good guys very often DO finish first.If, like Bernhard Langer, we want to win on a consistent basis – in whateverfield or area we “compete” in – we have to work on improving each movewe make, each word we say, each thought we entertain, and each activitywe take part in. We can’t just look at the big picture at the Birthdays - December 29252

They are either extremely careful about theirhealth or amazingly unconcerned. ACapricorn born on December 29 has theability to be transformed by spiritualsignificance, but only after experiencing aprofound and transfiguring reality. Oftenattractive and charming, they have adevastating effect upon those who comeunder their spell. Unlike most Capricorns,they enjoy taking risks. People born onDecember 29 want to make their personallives work.217 **********************************************Carl Albert Paulson - Pete Dye - RobertDinwiddie - Martin Laird Birthdays - December 30Because they have a healthy appetite forgood things, they need to be involved in anexercise regimen and cut back on sweetsand fatty foods. A Capricorn born onDecember 30 is a jovial individual whopromotes the status quo. They like the goodlife and are willing to work long and hard toachieve it. They are focused and understandthe need to make sensible sacrifices. Theseindividuals are happiest when they have astable family and happy home life.217 **********************************************Kris Tschetter - Yukari Baba - MichelleMcGann - Wilf Homenuik Birthdays - December 31A December 31 Capricorn responds to theirheart, not their head. They may beimpractical in the extreme, but they also painttheir world in vibrant and extreme colors. Acertain brilliance does not shield them from agreat deal of instability. This can be adrawback to maturation, yet it also providesthem with the emotional exhilaration theycrave. They possess natural vitality thatallows them to neglect exercise and nutritionwithout seriously affecting their health.217 **********************************************Michael Francis Bonallack - Richard BerniceCooper - Miki Saiki Rookie on Tour: The Education of a Pga Golfer by Carl Paulson and Louis H. Janda: It answered so many questions I have always wondered about. How do you really get on the Tour? How do you stay there? What kind of perks are offered to pro golfers? What is the inside life really like? If you play good golf and have always toyed with thoughts of trying to play professionally, this book is for you. Paulson provides those answers plus his own personal experiences in actually doing it all. I learned about some of the inner workings of the tour and how difficult life really is for these players. The other books I have read that say they are an inside view of the tour are written by outsiders and are mainly summaries of the year with a few extra quotes thrown in.219 253

end of the journey, we have to look carefully at each step along the way.328 ===================== NAD Energy = Ratio ofMy Interpretation of Bernhard Langer's Champion's Dinner329 Lactate to Glucose MeningitisIngredients:• 1 1/4 pounds veal top round cut in 5-ounce scaloppines -------------------------------------• 1/2 cup packed flat leaf parsley, rinsed well-dried and coarsely chopped• Cucumber or bibb lettuce salad in vinaigrette dressing The comparison of the CSF• 2 cups unseasoned bakery bread crumbs lactate level with the other• 2 cups vegetable oil tests routinely performed• 2 tablespoons heavy cream showed that the CSF lactate• 3 tablespoons unsalted butter level had the highest• Salt and freshly ground white pepper sensitivity, specificity and• 1 cup flour predictive values. The CSF• 2 eggs lactate level on the first ST• 4 lemon wedges had no prognostic value, but a rapid decrease of the CSFDirections: lactate during the treatment1 One at a time, place veal pieces in heavy 1-quart plastic bag and pound is indicative of good prognosis. thin with pounder. Place veal on large platter and lightly salt and pepper both sides. Among the pretreated2 Put flour in a shallow bowl wide enough to hold a piece of veal flat. Put cases, a high lactate level eggs and cream in a similar bowl. Beat to a blend. Put bread crumbs in could be an indication that a third similar bowl. bacteria were the causal3 Heat oven to 175 degrees. Line baking sheet with parchment. Arrange agents. In conclusion, the bowls near stove, along with a platter covered with layers of paper towel measurement of the CSF and a small plate covered with layers of paper towel. lactate, quickly performed4 Heat oil in an 11-12 inch skillet or saute pan, the deeper the better. and inexpensive, is worth When oil is quite hot put parsley in a strainer, put in oil and fry for 10 performing when a seconds. Remove parley, draining well and place on small plate. Add meningitis is suspected, as it butter to skillet and adjust heat to medium. appears to be the best way5 Put 1 slice veal in flour, cover well, then shake off excess. Deep in egg, of distinguishing bacterial turning to coat. Put in breadcrumbs, coating well, then shake off from non-bacterial excess. Put in skillet and fry for about one minute, gently moving the meningitis.158 pan in a circular motion on the burner. The oil should be frothy. When breading looks bubbly and starts to brown, turn and cook for another ===================== minute, then transfer to paper towel lined platter. Repeat with remaining NAD Fact Sheet veal, adjusting heat so crumb coating cooks gradually and evenly without burning. -------------------------------------6 Place the cooked, drained schnitzels on a baking sheet and put in oven until ready to serve, up to 15 minutes. Arrange veal on platter and Collectively, our study has individual plates. Garnish with lemon wedges and fried parsley and provided the first evidence serve with salad. that NAD+ treatment can decrease the survival of===========================oOo========================== tumor cells by such mechanisms as inducing Methyl Sulphonyl Methane oxidative stress. MIO Smoothie Ingredient------------------------------------------------------------------------------------------------- MSM, or methyl sulfonyl methane, is a naturally occurring sulfur compound found in the body and in green vegetables, milk, fish, and grains, marketed as a dietary supplement. Methylsulfonylmethane is in the fluid and tissues of all living organisms and in many plant and animal foods. MSM, in its purified form, can be described as anodorless, tasteless, white, water soluble, crystalline solid.Methylsulfonylmethane (MSM) is a well-known supplement used fornumerous conditions including pain, inflammation, allergies, arthritis, and inmaintaining normal levels of keratin in hair, skin and nails. MSM is claimed254

to have remarkable pain-relief power owing to the fact that it's a relative of Because NAD+ treatmentDMSO, another more well-known prescription sulfur compound that's long can selectively decrease thebeen said to relieve pain. Until recently there have only been few studies on survival of tumor cells,MSM, and a lot of the reports on the benefits of MSM supplement had been NAD+ may become a novelanecdotal. However, there have been new findings that MSM supplements agent for treating cancer.159are indeed beneficial, particularly in arthritis and seasonal allergic rhinitis. =====================MSM serves as an important source of bioavailable dietary sulfur, an NAD Energy = Ratio ofelement necessary for healthy cartilage and liver detoxification processes. It Lactate to Glucoseis an vital component of proteins found throughout the body, such as in hair, Migraine and Headachesnails, skin and tendons. MSM is found in small amounts in everyone's blood Average NAD Level 78and it is also found in many foods.436; 437; 438 Normal is 100+ ===========================oOo========================== ------------------------------------- Hunter's Macaroni and Cheese To study mitochondrial abnormalities in patients with Hunter Mahan chronic primary headaches,------------------------------------- ------------------------------------------------------------ lactic acid and pyruvic acid levels in plasma were Hunter Mahan withdrew Friday measured. morning from the Australian Open because of soreness The migraine group showed behind his right shoulder, significantly higher means raising questions about for plasma lactic acid and whether he can play next week pyruvic acid than the control in the Presidents Cup. Mahan group. The means in the TH said he fully expects to be play group were lower than in the at Royal Melbourne, and migraine group and believes he will be ready to goafter a few days of rest. The pain is nothing new, although he said typically group were lower than in theit has been behind the left shoulder. migraine group and higher than in the control group,Mahan tried to play Friday morning. He said the pain tends to go away once without significanthe warms up, but that wasn't the case. Physical therapists worked on his differences.shoulder, and his shirt was untucked on the range as he debated playing.Ultimately, he decided it was better to rest. These results may support the hypothesis that migraine\"It came on Wednesday night, and Thursday it wasn't great,\" Mahan said. patients have functional\"Today was the worst it has been. The more I keep swinging, the worse it abnormalities in theirgets. But I don't see this being a long-term problem for next week.\"330If Hunter Mahan wins the Masters Tournament, the first item on hisChampions Dinner menu will be macaroni and cheese. That was part of hisvictory dinner after he won in Phoenix earlier this season. \"Mac andcheese; that's a must, I think, after a win,\" Mahan said. And what winegoes with macaroni and cheese? \"I usually go red,\" he said329My Interpretation of Hunter Mahan's Favourite Meal - Chef Hubert Keller -Creamy Macaroni and Cheese with Prawns, Mushrooms and FreshHerbs331Ingredients• 1 cup white mushroom, sliced• 5 tablespoons chopped parsley• 4 tablespoons butter• 3 large carrots, diced• 1 large onion, diced• 1/2 quart cream• 4 ounces half and half• 1 1/2 cup Swiss cheese• 2 pounds prawns, diced• 1 pounds cooked pasta• 1 cup whipped cream• 6 egg yolks• Salt and pepper to taste255

Directions mitochondrial energy1 In a large pot, add butter, carrot, onion and sweat for 5 to 10 minutes. metabolism.1602 Add the cream, salt and pepper and simmer until it gets thicker (10 to ===================== 15 minutes). NAD Fact Sheet3 Add the mushroom and Swiss cheese, simmer for 5 minutes.4 Add the prawns and pasta and mix gently until very hot. -------------------------------------5 Fold into the whipped cream the parsley and egg yolks.6 Season with salt. Proteins that bind and/or use7 Transfer Macaroni and Cheese into bowl and cover lip with the whip NAD(H) as a co-substrate (such as, CtBP and cream mix. PARPs/Sirtuins respectively) are known to induce===========================oOo========================== changes in chromatin structure and transcriptional Mushroom Porcini profiles. MIO Smoothie Ingredient In fact, their ability to sense------------------------------------------------------------------------------------------------- perturbations in NAD(H) levels has been implicated in Known as the king of wild their roles in development, mushrooms, the porcini, or stress responses, metabolic cepe, mushroom, is widely homeostasis, reproduction hunted and harvested and aging or age-related throughout Europe, North diseases. America, Australia, China, and Mexico. Porcini mushrooms It is also becoming have a long, fleshy stalk, up to increasingly clear that both 10 inches (25cm) in length. The the levels/activities of these cap is fleshy, round, and proteins and the availability convex, and can be smooth or of NAD(H) are equally velvety. The underside of the important.161cap differentiates the porcini from most other mushrooms, as it is coveredwith vertical tubelike pores instead of gills. Porcini mushrooms have a rich, =====================woodsy aroma. NAD Energy = Ratio of Lactate to GlucoseThe health benefits of dried shiitake mushrooms and porcini mushrooms Mitochondrial Disordersare many. They deliver a powerful blast of antioxidants that support theimmune system and help to fight off harmful free radicals that are thought -------------------------------------to be a cause of many different types of cancer. Antioxidants are veryimport to help build a strong immune system that can protect a person from Mitochondrial disorders areinfections. With the looming threat of the H1N1 virus, all the extra protection characterized by anwe can give our bodies is very important. accumulation of lactate and an insufficient oxygenMushrooms are also a fat free food, which is helpful when you need to lose extraction from blood duringweight. What’s more is that mushrooms have no cholesterol and less than exercise. Therefore, both1% of your daily value of sodium. Although not a lot, mushroom nutrition parameters (lactate andfacts also reveal small amounts of protein, carbohydrates and fiber which oxygen saturation) can beaid in fat loss. used as screening tests in mitochondrial disordersMushrooms may be small but nutrition facts prove that they have plenty ofvitamins and minerals. One cup of mushrooms includes vitamins C, D, B6 There were significantand B12, plus large doses of riboflavin, niacin and pantothenic acid. These correlations between thevitamins along with minerals like calcium, iron, potassium and selenium heteroplasmy and both thekeep you fit and in good health. degree of oxygenThe most sought after health benefit of mushrooms is weight loss. As alean protein, your body already burns plenty of fat just breaking down theprotein (and fiber), but when you consume foods low in fat and carbs thatfat burned increases for additional fat burning.Researchers charge the health sustaining and rejuvenation properties ofmushrooms to a group of long chained polysaccharides calledBeta-glucans. Beta-glucans have the property of being immune-potentiatingor immune enhancing. Beta-glucans exist in the bran and grains of cereal,the cell walls of baker’s yeast, in some bacteria and of course, theseimmune system assistants, these Beta-glucans are found in mushrooms aswell.436; 437; 438256

===========================oOo========================== desaturation and lactate 1984 Masters Champions Dinner increase in patients with single deletions. In patients Spanish Omelette & Steak who performed both protocols (n = 16) a Seve Ballesteros combination of both tests------------------------------------- ------------------------------------------------------------ increased sensitivity up to 87%. Seve Ballesteros died in the early hours of 7 May 2011 after Oxygen desaturation in a long battle with brain cancer. forearm exercise tests and Ballesteros was one of the lactate increase in cycle world's leading golfers from the ergometry tests show a high mid 1970s to the mid 1990s. specifity but only moderate sensitivity. Combination of In October 2008 Ballesteros the two screening test fainted at Madrid airport and clearly increases the was hospitalized. He confirmed sensitivity.162 that doctors had diagnosed amalignant tumor six days later. He then underwent a 12-hour operation to =====================surgically remove the tumor. Surgeons said they managed to remove most NAD Fact Sheetof the tumor. He went on to have three more operations. -------------------------------------Later on in the same month doctors confirmed that his tumor was acancerous oligoastrocytoma. On October 24, 2008 he had to undergo The importance of sirtuins infurther surgery to try to resect (surgically remove) the rest of the tumor after the regulation of manyhis health had deteriorated rapidly. After a 6½-hour operation doctors fundamental biologicalconfirmed the tumor had been removed.332 responses to various nutritional and environmentalMy Interpretation of Seve Ballesteros' Champion's Dinner333 stimuli has been firmly established. Sirtuins haveIngredients: also emerged as critical regulators for aging andSpanish Omelette Ingredients longevity in model• 280g / 10oz potatoes organisms.• 5 medium eggs Their absolute requirement• ½ medium onion of NAD has revived an• 1 large tomato enthusiasm in the study of• 110g / 4oz peas mammalian biosynthesis of• 3 tablespoons olive oil• Salt and pepper to tastePreparation1 Peel the potato(es), cut in half and slice as thinly as you dare. Scatter salt over the sliced potatoes and mix them up to ensure all have some salt on them. Peel the onion, cut in half and finely chop. Save the other half of the onion for use in another meal. Roughly chop the tomato with a sharp knife. Add two (not all three) tablespoons of olive oil to the frying pan. Heat at a medium setting. When hot, add the potatoes. Keep turning and separating them for 5 minutes. If they begin to turn brown, lower the heat2. Then add the chopped onions and mix well. Cover the frying pan, turn the heat to low. Turn the potatoes and onion every couple of minutes.3. Break the eggs into a large bowl (large enough to also take the potatoes and onion) and gently whisk them with a fork. Just enough to merge the whites and yolks together. Don't over do this whisking. Add salt and pepper.4. When the potatoes and onion are cooked, add them to the bowl of eggs. Add the tomatoes and peas.5. Add the remaining 1 tablespoon of olive oil to the pan and turn up the heat to medium. Wait one minute for the pan to heat then pour the bowl of eggs and vegetables into the pan. Immediately turn down the heat to the lowest setting.6. Leave the omelette to cook for 15 minutes at the lowest heat setting. When there is almost no liquid on the surface of the omelette turn it by257

putting a plate on top of the frying pan and turning it upside down. Put NAD.163 the omelette back in the pan.7. To round the edges, turn the edges of the omelette inwards with a ===================== spatula. Let the omelette cook for another 5 minutes. NAD Energy = Ratio of8. Cut the Spanish Omelette in half and serve on heated plates. If you Lactate to Glucose have some left over, cover it and place it in the fridge. It is equally Multiple Sclerosis delicious cold for breakfast or as part of a picnic. Average NAD Level 489. It's great on its own, especially if you have included the tomatoes and Normal is 100+ peas. It also goes well with a salad and some Spanish wine. -------------------------------------===========================oOo========================== Administration of Mustard pharmacological doses of non-tryptophan NAD MIO Smoothie Ingredient precursors ameliorates------------------------------------------------------------------------------------------------- pathogenesis in animal models of Multiple Sclerosis. Mustard seeds have been highly prized medicinal as Animal models of MS involve well as culinary spice being in artificially stimulated use since ancient times. autoimmune attack of myelin Mustards are native of Asia by experimental minor, but now cultivated as a autoimmune main commercial crop in encephalomyelitis (EAE) or Canada, India, China, and by viral-mediated temperate climates of demyelination using Thieler's European region. murine encephalomyelitis virus (TMEV). The Wld(S) Generally perceived as health mouse dramatically resistsbenefiting spice, mustard seeds are indeed very rich in phyto-nutrients, razor axotomy mediatedminerals, vitamins and anti-oxidants. The seeds are high in essential oils axonal degeneration.as well as plant sterols such as brassicasterol, campesterol , sitosterol,avenasterol and stigmasterol. They also contain sinigrin, myrosin, erucic, This resistance is due toeicosenoic, oleic and palmitic acids. increased efficiency of NAD biosynthesis that delays100 g of mustards provide 4.733 mg of niacin (vitamin B-3). Niacin is a part stress-induced depletion ofof nicotinamide co-enzymes, helps lower blood cholesterol and triglyceride axonal NAD and ATP.levels. Mustard seeds contain flavonoid antioxidants such as carotenes,zeaxanthin and lutein. In addition, the seeds have small amount of vitamin A comprehensive review ofanti-oxidants such as vitamin A, C and vitamin K. immunomodulatory control of NAD biosynthesis andMustards are rich source of many health benefiting minerals. Calcium, degradation in MSmanganese, copper, iron, selenium and zinc are some of the minerals pathogenesis is presented.especially concentrated in these seeds. Calcium helps build bone andteeth. Manganese is used by the body as a co-factor for the antioxidant Distinctive pharmacologicalenzyme superoxide dismutase. Copper is required in the production of red approaches designed forblood cells. Iron is required for the red blood cell formation and cellular NAD-complementation ormetabolism.436; 437; 438 targeting NAD-centric proteins (SIRT1, SIRT2,===========================oOo========================== PARP-1, GPR109a, and CD38) are outlined towards Jack's Hot Chicken Salad227 determining which approach Jack William Nicklaus-------------------------------------------------------------------------------------------------The year had started off so promisingly for Jack Nicklaus. But then hisseason of gold turned to brass. With the suddenness of a freeway pileup,his health, his game and his business slid toward the edge.But all the cheers in the world cannot stop them, those withering little insultsthat nature plays on the body. With age 60 looming, his hips were grindingwith pain, a groin pull flared up continually, and havoc and unruliness hadcrossed the border.258

\"My back,\" he would groan. \"It may work best in the context looks like a set of building of clinical application.164 blocks that a 4- year-old put together. My hip is now bone on ===================== bone.\" NAD Fact Sheet He went on to the U.S. Open, ------------------------------------- where he managed a credible tie for 43rd. But his pride took A century after the no joy from 43rd, and he finally identification of a threw in the towel on his coenzymatic activity forcontinuing run of majors that stretched back to 1962. Then in July at the NAD(+), NAD(+) metabolismSenior Open at Riviera, he seemed to be shuffling like an old man. His right has come into the spotlightfoot was hobbled by an eerie pain. Was it something serious? Tests would again due to the potentialreveal an unaccounted-for stress fracture.334 therapeutic relevance of a set of enzymes whoseIngredients: Serves 8. activity is tightly regulated by• 3 cups chopped cooked chicken breasts the balance between the• 8 oz. can water chestnuts, drained and sliced oxidized and reduced forms• 1 cup (4 oz.) shredded sharp Cheddar cheese of this metabolite.• 10 oz. can condensed cream of chicken soup• 2 oz. jar diced pimentos, drained In fact, the actions of• 3 oz. can French fried onions NAD(+) have been extended• 1 cup slivered almonds from being an• 2 cups chopped celery oxidoreductase cofactor for• 1 teaspoon salt single enzymatic activities to• 1 tablespoon lemon juice acting as substrate for a• 1 ½ cups mayonnaise wide range of proteins.165• ½ teaspoon pepper =====================Method: NAD Energy = Ratio of1 Preheat oven to 325 degrees. Lactate to Glucose2 Combine all ingredients except fried onions. Myalgic Encephalomyelitis3 Mix well. Average NAD Level 804 Spread into a buttered 9x13-inch baking dish. Normal is 100+5 Bake for 35 minutes.6 Sprinkle with the fried onions and bake for 10 minutes longer. -------------------------------------7 Remove to cool about 10 minutes before serving. By studying the oxidative properties of Epstein- Barr===========================oOo========================== virus-transformed B lymphocytes, we found that Nicotinamide Adenine Dinucleotide (NAD) the respiration was significantly decreased after MIO Smoothie Ingredient 3-4 days of cell culture.------------------------------------- ------------------------------------------------------------ Simultaneously, we observed decreased NAD+ plays a major role in the NAD(+)-dependent release of energy from glucose, oxidations (malate, notes the book \"Human Physiology, glutamate, pyruvate) that Eighth Edition,\" by Arthur Vander, became dependent upon the James Sherman and Dorothy addition of exogenous Luciano. To enable the breakdown NAD+. of glucose to continue, the body metabolizes pyruvate, which takes hydrogen from NADH, forming lactate and regenerating NAD+. This happens in the initial stages ofstrenuous exercise when the muscles' need for energy outpaces theirsupply of oxygen from blood. As long as glucose is available, the cycle canrepeat, converting glucose to forms of energy cells can use and, in theprocess, reconverting NADH to NAD+, observe Campbell, Reece andMitchell.One important process is energy metabolism, the means by which glucosederived from foodstuffs is converted to life-sustaining energy in the cells.Energy metabolism requires NAD, which is consumed (via chemicalreactions) in the process. The more food the organism eats, the more259

glucose is delivered to its cells to be metabolized, and the more NAD it The effect of NAD+ wasuses up. shown to be related to an influx of catalytic amount ofThat's bad news for the other, competing biological process that needs NAD+ into the mitochondrialNAD in order to work: gene silencing. This is a biochemical mechanism for matrix.166keeping most of the genes in the cell's DNA inactive, or \"silent,\" meaningthat they are not engaged in synthesizing the proteins their structures code =====================for. In all cells, some genes need to be active, or \"turned on.\" Most genes, NAD Energy = Ratio ofhowever, need to be silent (turned off) most of the time so that the genes Lactate to Glucosethat should be active can do their jobs without undue interference. Neurological DiseasesThe actual gene silencing is carried out by a protein, Sir2p, that the Sir2 -------------------------------------gene codes for. Exactly how Sir2p does this need not concern us here,except for one crucial fact. It turns out that Sir2p can accomplish its Lactic acid concentrationappointed task only with the help of NAD! No NAD, no gene silencing. No has been determined in thegene silencing, no life extension - in fact, probably life curtailment. cerebrospinal fluid (CSF) of 715 patients suffering fromNow think about it: if gene silencing requires NAD, but so does energy various neurologicalmetabolism, and there is only so much NAD to go around, what situation diseases.would be most favorable for gene silencing? The answer is reduced energymetabolism, because the lower the metabolism, the less NAD would be It was found to be mostrequired for that task, and, consequently, the more NAD would be available often elevated in cases offor gene silencing.335 ischemic cerebral infarction, cerebral contusion,===========================oOo========================== arteriosclerotic dementia, metastatic encephalitis, Jaco's Chicken and Red Cabbage Wrap19 bacterial meningitis, menigiosis carcinomatosa Jaco Ahlers and after epileptic seizures.------------------------------------------------------------------------------------------------- In fewer cases lactate levels According to Jaco Ahlers, were increased with brain Erinvale Golf Estate’s 17th is a tumors, encephalitis, viral tricky hole to navigate. Ahlers meningitis and radiculitis.167 had to do so when he won there two years ago. “You have to deal ===================== with cross winds on the 17th NAD Fact Sheet which means that your drive has to be exceptional. -------------------------------------There is also a small sloping green that makes it an even trickier hole to Mounting evidence attests toplay.” Marc Cayeux, Jaco Ahlers and Jeremy Kavanagh earned spots in the paramount importance ofthe 2009 British Open through qualifying in South Africa. the non-redox NAD functions. Indeed, NADIngredients: homeostasis is related to the• 1 x Chicken Breast free radicals-mediated• 1 x Small Carrot (Peeled) production of reactive• 3 x Red Cabbage Leaves (Washed and Dried) oxygen species responsible• 2 tbs Honey and Mustard Salad Dressing for irreversible cellular• 1 x Baby Marrow damage in infectious• 5 x Cherry Tomatoes disease, diabetes,• 1 x Flour Tortilla inflammatory syndromes,• ½ tsp Olive Oil neurodegeneration andDirections1 Cover chicken breast with half teaspoon Olive Oil and season to taste, grill chicken breast in pan for 4 minutes per side.2 Place Chicken breast on wooden board to cool down3 Roll Cabbage leaves up like a pancake and thinly slice cabbage roll, place into glass bowl4 Julienne Carrots and Baby Marrow and add to Cabbage5 Quarter Cherry Tomatoes and add to other vegetables6 Shred cooled chicken breast with fingers and add to vegetable7 Add 2 tablespoons Honey and Mustard Salad dressing to Vegetables and Chicken, season with salt and pepper and mix well8 Place Flour Tortilla in microwave for 20 seconds 260

9 Place Flour Tortilla on serving plate, spoon Chicken and Vegetable in cancer. down the centre of your wrap leaving a space at the bottom, fold over the bottom piece over your filling, fold over the left side of your tortilla, Because the cellular redox make small fold on the right side of the tortilla to lock the bottom flap of status depends on both the the tortilla, now fold over the remaining side and enjoy!! absolute concentration of pyridine dinucleotides andVariation : their respective ratios ofSubstitute Carrots and Baby Marrow with ¼ Crumbled Feta and ¼ Avocado oxidized and reduced formsGrill Chicken Breast with Chili and Garlic (i.e., NAD/NADH and NADP/NADPH), it is===========================oOo========================== conceivable that an altered regulation of the synthesis Niacin and degradation of NAD impairs the cell redox state MIO Smoothie Ingredient and likely contributes to the------------------------------------- ------------------------------------------------------------ mechanisms underlying the pathogenesis of the above Niacin works with vitamin B1, mentioned diseases.168 riboflavin (vitamin B2), pyridoxine ===================== (vitamin B6), pantothenic acid, and biotin to break down and NAD Energy = Ratio of convert the carbohydrates, fats, Lactate to Glucose and proteins in food into energy. Neurological Diseases As such, vitamin B3 is crucial in metabolizing carbohydrates, fats, ------------------------------------- and proteins to produce energy. Involvement of Niacin, an The concentrations of essential B vitamin, in cellular glucose, pyruvate andenergy production means that it is of paramount importance for healthy lactate were determined incardiovascular function, nervous system function, and immune function. It the blood and lumbar CSF ofis also helpful in the synthesis of hydrochloric acid, which is required for 63 patients withproper digestion. neuromuscular disorders and 40 controls.Additionally, vitamin B3 enhances the body's ability to eliminate toxins. The The glucose/lactate andname niacin is taken from NIcotinic ACid + (IN). When the properties of lactate/pyruvate ratios wereniacin were first known, it was thought wise to choose a common name also calculated, in addition toother than nicotinic acid, for fear that it might be associated with nicotine, the cytoplasmicwhich may lead to notions that either smoking provided vitamins or that NADH/NAD+wholesome food contained a poison. (nicotinamide-adenineNiacin plays a key role in clearing the body of toxic and harmful chemicals.It also helps the body synthesize numerous sex and stress-relatedhormones in the adrenal glands and other parts of the body. Vitamin B3 isneeded for the action of many enzymes in the body. Enzymes are specialsubstances that catalyze or speed up chemical reactions in the body. Theseenzymes are responsible for generating energy in the body, breaking downdietary fats, the creation of certain hormones and cholesterol, theprocessing of genetic material (DNA) and the growth and maturation of thecells in the body. Niacin is potent in enhancing circulation and loweringcholesterol levels in the blood.Niacin needs can be met partially by incorporating high protein foods in thediet because the human body is able to convert tryptophan, an amino acid,into niacin. Niacin, through its analogs, is involved in a variety of metabolicand biological processes, including energy production, fatty acid synthesis,cholesterol and steroids, signal transduction, the management of geneexpression and the maintenance of genomic integrity. Nicotinic acid, inclinical and pharmacological applications, is used as an antihyperlipidemicagent. Niacinamide is also helpful in treating osteoarthritis, rheumatoidarthritis, insomnia, migraine headaches, and insulin-dependent diabetes.Vitamin B3 (Niacin) heightens good cholesterol (HDL) while lowering badcholesterol (LDL), and can also enhance the effectiveness of somemedications prescribed to lower cholesterol.Niacin, or vitamin B3, works with other B vitamins to produce energy in thecells, and to control circulation, hormones, glucose, and hydrochloric acid inthe body. Niacin also works intimately with riboflavin (vitamin B2) and261

pyridoxine (vitamin B6) to maintain healthy skin, and ensure the smooth dinucleotide-H/nicotinamide-operation of the nervous and digestive systems. Niacin is also useful in adenine dinucleotide) ratio intreating dizziness and ringing in the ears, Raynauds syndrome, PMS, the brain.headaches, cramps, and circulation problems. Niacin is a vasodilatormeaning it makes your blood vessels widen, which in turn leads to Remarkable deviations fromimproved circulation.436; 437; 438 control values were found not only in blood but also in===========================oOo========================== the CSF of patients with different neuromuscular James' Boere Barbeque13 diseases, particularly in Duchenne muscular James Kingston dystrophy and peroneal------------------------------------------------------------------------------------------------- muscular atrophy, indicative of disturbance of the After three second place carbohydrate metabolism in finishes on The European the central nervous Tour, James finally achieved system.169 his long-awaited breakthrough when winning the South ===================== African Airways Open at Pearl NAD Fact Sheet Valley in December 2007. Arguably his claim to fame ------------------------------------- came prior to his victory from one of the more bizarre shots Although baseline of his career when, in 2002, he requirements for won an Audi TT Coupe for an nicotinamide adenine amazing hole in one at the dinucleotide (NAD+) 15th hole at Houghton Golf synthesis can be met either Club during the dunhill with dietary tryptophan or championship. with less than 20 mg of daily niacin, which consists ofUsing a four iron, the ball initially veered off line but struck some branches, nicotinic acid and/ordropped onto the green and rolled into the cup. As well as the car, it also nicotinamide, there isearned him instant global fame as the bizarre ace was beamed around the growing evidence thatworld as CNN's Play of the Day. He has won eight times on the Sunshine substantially greater rates ofTour and a further five times on the Asian Tour, reflecting his status as a NAD+ synthesis may beglobal golfer. beneficial to protect against neurological degeneration.170In 2009 James won his first European Tour event outside his native SouthAfrica clinching the Mercedes-Benz Championship title in a sudden death =====================play-off against Denmark's Anders Hansen. James sunk a three foot put on NAD Energy = Ratio ofthe last to take the title.336 Lactate to Glucose ObesityMy Interpretation of James Kingston's Favourite Meal - Breakfast on the Average NAD Level 63Braai337 Normal is 100+At its most basic, the South African BBQ recipe for breakfast is cooked on a -------------------------------------skottle (or plough disc - or shear) in which case it usually includes friedeggs, fried tomatoes and quite often bacon, sausage and sometimes evenchips as well. This version is tantamount to using a large frying pan-typecooking utensil to cook everything all together outdoors.The quantity of food you cook will depend on the number of people you arefeeding and the amount of food they eat. This is more than enough for sixpeople; increase the number eggs and tomatoes if you wish.You can use a skottle over an open fire, or you can cook on a gas versionthat you will find at most stores that stock BBQ utensils. You can add a littleolive oil or a dollop of butter to the pan before you start cooking, but usuallythere will be plenty of pan juice from the boerewors and the bacon for youto cook all the other food.Ingredients• 2 kg traditional South African boerewors made with different types of meat and spices; or substitute with some other type of sausage, preferably beef.• 250 g bacon262

• 10 eggs Serotonergic involvement• 6 tomatoes has been implicated in• 4 onions sliced preferential consumption of• salt and pepper to taste treat foods. We tested the• fresh bread effect of acute tryptophan depletion (ATD) on foodMethod consumption by overweight1 Start by cooking the bacon and sausage on a hot plough disc. Turn and lean adults with and without a history of recurrent several times during the cooking process. Slice the tomatoes in half and major depressive disorder place around the outside of the meat, cut sides uppermost. (MDD).2 Turn the tomatoes only once. Make space for the onion slices in the centre of the pan and allow them to simmer in the pan juices. When Four food items of everything else is cooked, fry the eggs in the pan juices. comparable palatability were3 Sprinkle the onions, tomatoes and eggs with a little salt and pepper. offered as a part of the test:4 Serve and use fresh bread to soak up any pan juices left in the pan, two sweet (one which is the secret of success when it comes to this South African BBQ carbohydrate-rich, and one recipe. protein-rich) and two non-sweet (one===========================oOo========================== carbohydrate-rich, and one protein-rich). Niacinamide As compared to the placebo MIO Smoothie Ingredient challenge, ATD significantly------------------------------------- ------------------------------------------------------------ increased sweet calorie intake among overweight Niacinamide, also called participants and increased nicotinamide, Vitamin B3 and/or their propensity to consume Nicotinic Acid Amide, is a water sweet food first before any soluble member of the family of B other type of food.171 vitamins. There are two commonly used forms of Vitamin ===================== B3, Niacin and this form, NAD Fact Sheet Niacinamide. The chemical difference between these form is ------------------------------------- that this Niacinamide form has an Nicotinamide adenine amide group attached to the basic dinucleotide (NAD(+)) is the Niacin form. But there are universal currency of energyadditional differences in these forms regarding their nutritional use. metabolism and electron transfer.Whereas the more basic Niacin form is typically used in lowering blood lipidlevels (including LDL Cholesterol), this amide form is commonly taken and A symposium in Hamburg,has been demonstrated clinically to help reduce lipid accumulations from Germany, brought togetherarterial walls and it is also helpful in stabilizing blood sugar levels of type I 120 researchers fromdiabetics. Additional benefits of Niacinamide supplementation include various fields, who were allcognitive improvement in the elderly, treating acne, and helping to reduce engaged in the molecularfatigue in some individuals. characterization of the key players of NAD(+)Niacinamide has been clinically demonstrated to help reduce and prevent signaling.172the onset of Type I Diabetes in experimental subjects. Niacinamideenhances and protects insulin sensitivity and secretion, by helping to =====================pancreas beta cell function and metabolism. Topical gels and creams using4% Niacinamide (by weight) are commonly available and have beendemonstrated effective as acne treatments in clinical trials when appliedregularly over a minimum of 4 to 8 weeks.436; 437; 438 ===========================oOo========================== Jared's Chicken Pasta19 Jared Harvey------------------------------------- ------------------------------------------------------------263

Jared Harvey - Current 2011 SA NAD Energy = Ratio of Amateur Champion. WP Open Lactate to Glucose Champion. Captain of the 4 Osteoporosis Nations Cup team for South Africa to New Zealand. Part of a 2 ------------------------------------- Man South African team to participate in the Juan Carlos Changes in NAD+ and its Tailheade Cup, and Argentina metabolites contribute to Amateur Championship in longevity and November. age-associated diseases.Harvey followed in his dad’s footsteps this February when he won the The role of NAD+South African Stroke Play Championship in a playoff over Scotland’s David metabolism in boneLaw. George Harvey won the South African Stroke Play Championship diseases has however nottwice, in 1973 and 1976. been investigated, despite the fact that osteoporosis isHarvey senior first introduced his young son to the game when he was only a leading cause of morbiditya three years old, taking the toddler to Mount Edgecombe Golf Club in the in old age.rolling hills of KwaZulu Natal just North of Durban. Jared has continued todo father George proud. In April, he added the Western Province Amateur TRAP(+) osteoclastChampionship to move into 13th place on the World Amateur Golf Ranking formation from C57 Bl/6Jto cement his status as the world’s highest ranked South African amateur. mice was assessed after the addition of varyingIngredients: concentrations of NAD+ metabolites or exogenousChicken, ham, mushrooms, cream and linguine pasta. Great for when u ADPribosyl cyclase andaway on golf! At home my fav is a roast chicken NADase enzymes.===========================oOo========================== The NAD+ metabolite cyclic ADPribose (cADPr) or Nutmeg exogenous addition of the enzyme ADPribosyl cyclase MIO Smoothie Ingredient stimulated osteoclast------------------------------------------------------------------------------------------------- formation. Blocking cADPr action with the antagonist Wonderful, rich in fragrance 8-Br-cADPr potently inhibited nutmeg is one of the highly osteoclast formation.173 prized spices known since antiquity for its aromatic, ===================== aphrodisiac, and curative NAD Fact Sheet properties. Nutmegs are evergreen trees, native to the ------------------------------------- rain forest Indonesian Moluccas Island, also known as the Spice Islands. Nutmeg spice as well as macecontains many plant derived chemical compounds that are known to haveanti-oxidant, disease preventing and health promoting properties. Theactive principles in nutmeg have many therapeutic applications in manytraditional medicines as anti-fungal, anti-depressant, aphrodisiac, digestiveand carminative functions.The spicy nut contains fixed oil trimyristin and many essential volatile oilssuch as which gives sweet aromatic flavor to nutmeg like myristicin,elemicin, eugenol and safrole. The other volatile oils are pinene, camphene,dipentene, cineole, linalool, sabinene, safrole, terpeniol.This prized spice is a good source of minerals like copper, potassium,calcium, manganese, iron, zinc and magnesium. It is also rich in many vitalB-complex vitamins including vitamin C, folic acid, riboflavin, niacin, vitaminA and many flavonoid anti-oxidants like beta carotene and cryptoxanthinsthat are essential for optimum health.436; 437; 438===========================oOo========================== Jay’s Favorite Salad227 Jay Dean Haas264

------------------------------------- ------------------------------------------------------------ NAD+ and NADH have been Jay Dean Haas has still featured emerging as the common in the top 20 of the Official World mediators of energy Golf Rankings after his 50th metabolism, mitochondrial birthday. In 2005, he won twice functions, calcium on the Champions Tour, while homeostasis, aging and cell also continuing to play regularly death. on the PGA Tour. NAD+ and NADH can affect I do everything well and I'm the cell death by various best at nothing. My strength mechanisms, such as through the years has been my influencing energyhealth. I've been injury-free for a pretty long time. I never was The Guy. I metabolism, mitochondrialwas never a top-five player. I won't say I've never have thrown in the towel permeability transition pores,in a Tournament, but generally speaking if I get over par in an event I'm not and apoptosis-inducinggoing to pack it in. Out of 592 cuts, there we re probably 25 that I shouldn't factor.174have made but did because I kept hanging in there. =====================Jan was planning the meal, and she said they were sitting at this huge NAD Energy = Ratio ofboard room table with 15 people there. One of them asks, \"What's his Lactate to Glucosefavorite meal?\" And she says fried chicken gizzards, which is true! I just Over-Training Syndromelove 'em! I've eaten them since I was a kid. My dad used to eat 'em all the Average NAD Level 77time. You've gotta try 'em. Normal is 100+Anyway, she said their mouths just dropped open, like, \"Who eats fried -------------------------------------chicken gizzards?\" Anyway, they brought out this heaping plate of friedchicken gizzards and they were wonderful. I passed them around and it waslike the plague going by under everybody's noses. A few people triedthem.338Ingredients:• 3 bags romaine lettuce• 4 small Granny Smith apples, sliced• 8 oz. grated Swiss cheese• 8 oz. crushed cashewsDressing:• ¾ cup sugar• 1/3 cup red wine vinegar• 1 teaspoon dry mustard• 2 tablespoons poppy seeds• 1 teaspoon salt• 1 cup oil• 1 ½ tablespoons finely chopped onionMethod:1 Mix dressing well and toss into salad.===========================oOo========================== Many indicators of over-reaching and Olive Leaf Extract over-training have been proposed, using both MIO Smoothie Ingredient physiological and------------------------------------- ------------------------------------------------------------ psychological techniques. Olive leaf guards against viral, Field testing of athletes has bacterial and retroviral attack. Olive led us to believe that a leaf is loaded with phytochemicals decrease in the ratio of (compounds that occur naturally in blood lactate concentration plants for their protection) to ratings of perceived especially oleuropein, a natural antibiotic that is applied throughout the body. Olive leaf can be safely used on a daily basis as a preemptive strike against illness.265

Olive leaf extract (OLE), as the name indicates, is derived from the leaves exertion indicates a fatiguedof the olive tree (scientific name Olea europaea). An unprocessed leaf and/or over-reached statecontains strong antioxidant compounds like oleuropein, hydroxytyrosol following intensive training.along with other polyphenols and flavonoids. These active ingredients are During each time period anresponsible for imparting the bitter taste and pungent flavor to the olive incremental exercise testleaves. was performed to maximal effort with blood lactateOne of the latest discoveries about olive leaf extract is the ability to fight concentration (HLa) anddisease causing microorganisms. The compound behind this miracle is ratings of perceived exertioncalcium elenolate, a powerful active ingredient present in the foliage of olive (RPE) obtained for eachtrees. This compound possesses strong antibacterial and antiviral workload.properties. When bacteria and viruses encounter this substance, theirreplication is hindered rendering them unfit for further spreading of All seven subjects becamedisease436; 437; 438 over-reached during the two ===========================oOo========================== week period of intensive interval training. Examining Jbe's Barbeque13 the individual data revealed that at maximal workload all Jbe Kruger seven subjects had------------------------------------------------------------------------------------------------- HLa:RPE ratios of less than 100 when over-reached. James Barry Kruger enjoyed a superb season in 2010 and The ease and speed at was unlucky to not win a which the HLa:RPE ratio can maiden Asian Tour victory. be determined may make it After a fourth place finish at useful for coaches and the season-opening Asian athletes in monitoring Tour International in intensive exercise training Bangkok, he registered and recovery.175 second place outings in the Brunei Open, losing to ===================== Siddikur in a play-off, Handa NAD Fact Sheet Singapore Classic and King's Cup in Thailand. ------------------------------------- Also finished tied 10th at the Evidence indicates thatHero Honda Indian Open to finish the season in a commendable 19th place NAD(+) metabolism andon the Order of Merit. He also won the Greens in Regulation category. In sirtuins contribute tohis rookie season in 2009, Jbe got off to a flying start, making eight mechanisms that influenceconsecutive cuts that were highlighted with three top-20 finishes in the cell survival under conditionsMaekyung Open in Korea, Brunei Open and Queen's Cup in Thailand. of stress and toxicity. For example, recent work hasJbe’ Kruger’s flu couldn’t have come at a worse time. He is back at the shown that sirtuins andZambia Open this week to defend his first title on the Sunshine Tour. Last increased NAD(+)year, the South African from Bloemfontein shot 6 under on the back nine at biosynthesis provideNdola Golf Club to beat Titch Moore by two strokes. Kruger since has won protection against neuronthe Zimbabwe Open in April. But his trip to Brunei earlier this month ended axonal degeneration initiatedbadly. Not only did he lose in a playoff to Rahman Siddikur in the Asian by genotoxicity or trauma.Tour’s Brunei Open, but he came home with influenza.339 In light of their protectiveMy Interpretation of Jbe Kruger's Favourite Meal - Stuffed Beef Fillet340 effects, sirtuins and NAD(+) metabolism could representIngredients• 1.5kg (3lb) beef fillet, trimmed• Salt & black pepper• 2 Tbsp melted butter (substitute olive oil)For the stuffing:• 100g canned soked oysters• 3 Tbsp fresh breadcrumbs• 3 Tbsp fresh parsley, chopped• ½ tsp dried thyme• ½ tsp rosemary• Salt & black pepper• 2 Tbsp melted butter• 1 small onion, chopped• 1 clove garlic, chopped266

• 2 Tbsp dry sherry therapeutic targets for• 3 Tbsp sour cream treatment of acute and chronic neurodegenerativeMethod conditions.1761 Make the stuffing first. Melt the butter (or heat the oil) & sauté the onion ===================== and garlic. Combine the oysters, breadcrumbs, parsley, thyme, salt & NAD Energy = Ratio of pepper. Add the onion, garlic (together with the oil/butter in the pan), Lactate to Glucose sour cream and sherry and mix well. Pathological Gambling2 Make an incision down one side of the fillet leaving, the 2 ends closed if Average NAD Level 71 possible. Alternatively, use a sharpening steel to make a hole down the Normal is 100+ middle of the fillet. Stuff the meat.3 Using a needle and thread, sew up the opening if the meat has been cut ------------------------------------- and tie with string to keep in shape. Season lightly and brush with melted butter. Pathological gambling (PG)4 Prepare an indirect fire and fit a foil drip tray between the coals. Place is a disorder classified as an meat in a roast holder and position it on the grid over the drip pan. impulse control disorder5 Cover the kettle and cook for 25-30 minutes, depending on the degree (DSM-IV) bridging impulsive, of rareness required. compulsive and addictive behaviors. The striatum andStand for a few minutes before carving. thalamus are supposed to be involved in the===========================oOo========================== pathophysiological substrate of these behaviors. An Olive Oil increased relative glucose metabolic rate (rGMR) in MIO Smoothie Ingredient patients with a diagnosis of------------------------------------- ------------------------------------------------------------ PG had previously been reported in the medial and The greatest exponent of orbitofrontal cortex. monounsaturated fat is olive oil, and it is a prime component of The PG patients had a the Mediterranean Diet. Olive oil decrement of the rGMR in is a natural juice which the ventral parts of the preserves the taste, aroma, striatum and thalamus, and vitamins and properties of the an increment of the rGMR in olive fruit. Olive oil is the only the dorsal parts as vegetable oil that can be compared with the controls. consumed as it is - freshly Lithium treatment increased pressed from the fruit. the ventral caudate rGMR to a trend level in the patients,The beneficial health effects of olive oil are due to both its high content of but had no effect on themonounsaturated fatty acids and its high content of antioxidative metabolism of either thesubstances. Studies have shown that olive oil offers protection against putamen or the thalamus.177heart disease by controlling LDL (\"bad\") cholesterol levels while raising HDL(the \"good\" cholesterol) levels. (1-3) No other naturally produced oil has as =====================large an amount of monounsaturated as olive oil -mainly oleic acid. NAD Energy = Ratio of Lactate to GlucoseOlive oil is very well tolerated by the stomach. In fact, olive oil's protective Panic Disorderfunction has a beneficial effect on ulcers and gastritis. Olive oil activates thesecretion of bile and pancreatic hormones much more naturally than -------------------------------------prescribed drugs. Consequently, it lowers the incidence of gallstoneformation.436; 437; 438===========================oOo========================== Jerry's Charbroiled Oysters Jerry Kelly------------------------------------- ------------------------------------------------------------267

If it wasn’t illness for Jerry A significant increase in Kelly, it was injury. If it wasn’t glucose metabolism was injury, it was inconsistency. found in the left He’s had them all over the hippocampus and past three years. Take 2008. parahippocampal area of the He started with a third-place panic disorder subjects in finish at the Sony Open in comparison with that found Honolulu, but then missed in the healthy subjects. In the cut in eight of 12 events, addition, a significant falling into a deep slump decrease in metabolism was before shaking it off with a found in the right inferior second-place finish at the parietal and right superiorMemorial. He followed that up by missing the cut at the US Open. temporal brain regions of the panic disorder subjects inThere were those two weeks in 2009 when he had to withdraw from the comparison with that of theHeritage Open because of illness, then won the Zurich Classic by a stroke normal subjects.over Rory Sabbatini, Charlie Wi, and Charles Howell. There was no significantThe worst, though, came last season, when a back injury forced Kelly to correlation between scorespull out of the Sony and then the Bob Hope in January. “My last three, four for the severity of panicyears - other than the win in ’09 - it’s really been quite a struggle,’’ Kelly disorder or for the severity ofsaid. “Health at times, and then when I’m healthy, brain. You never know.’’ lactate-induced panic attack and the quantified PETIt’s been a matter of changing his mentality, according to Kelly. But he’s had abnormality.to get that to agree with his swing. “So all of a sudden my swing and what Iwas trying to do with my mental side, they were matching up,’’ he said. “I These data provide furtherwas able to stay in that mode all the way through a round, which was support for the hypothesis ofdifficult for me in the past. I’d go after it, I’d try to get something back or I’d an abnormal braintry to go further. I’d always be fighting it. I don’t think I had the swing or the metabolism in thebody to smooth it out correctly like I am now.’’341 hippocampal and parahippocampal area inAfter Jerry Kelly won the 2009 Zurich Classic, he devoured a large tray of individuals with paniccharbroiled oysters from Drago's Restaurant during his post-round press disorder and also suggestconference. Little wonder that Kelly loves —loves, he'll tell you — playing other areas of aberrant brainthe Zurich Classic. The marriage of the Tournament and some of the metabolism in thisworld's best restaurants is an appetizing lure for both players and fans. The disorder.178culinary roll call includes Galatiore's, Emeril's, Arnaud's, Barreca's,Broussards, Boudreaux's, Café Dumonde, and the Acme Oyster House. ===================== NAD Fact SheetDuring Wednesday's pro-am, each tee was home to a delectable delight,including barbecue shrimp and grits, crawfish remoulade, bread puddingwith whiskey sauce, assorted crab cakes, steak sandwiches and sauces.On the driving range were beignets and Asian Cajun gator. And the food isavailable throughout the Tournament, with 27 restaurants to choose from.\"I have told everybody that when I win the Masters, charbroiled oysters fromDrago's will be on the Champions Dinner menu,\" Kelly said. \"It's incrediblethe food that is available. The restaurants are institutions to me. When I'mhome, I like to cook. It's my hobby. I'm in awe of these people like EmerilLagasse, Susan Spicer, Paul Prudhomme and John Besh. I want to beback in the kitchen with them and watch the action. I love their creativity.But you don't have to be a cook to know this food is great.\"342My Interpretation of Jerry Kelly's Favourite Meal - Charbroiled Oysters fromDragos343Ingredients: Servings: 8• 32 oysters, on the half shell• 1 cup butter• 2 tablespoons finely chopped garlic• 1/2 teaspoon fresh ground black pepper• 1/4 cup grated parmesan cheese• 1/4 cup grated pecorino romano cheese• 1/2 cup finely chopped parsley268

Directions: -------------------------------------1 Heat the grill to med-high. This exquisiteness of NAD+2 Melt butter with garlic and pepper in a large skillet. and NADH metabolism3 Mix Parmagiano and Romano cheeses in a small bowl. could epitomize the4 Spoon some of the melted butter mixture onto each oyster. exquisiteness of life, through5 Add a pinch of the combined cheese to each oyster, add a pinch of which we may grasp the intrinsic harmony life has parsley. evolved to produce. The6 Place oysters on the grill. exquisiteness also suggests7 Grill oysters until they are hot, bubbly and puffed, about 8 minutes. a central regulatory role of NAD+ and NADH in life.===========================oOo========================== It is tempted to propose that Orange NAD+ and NADH, together with ATP and Ca2+, MIO Smoothie Ingredient constitute a Central------------------------------------- ------------------------------------------------------------ Regulatory Network of life. Delicious and juicy orange fruit Increasing evidence has contains an impressive list of also suggested that NAD+ essential nutrients, vitamins, and NADH play important minerals for normal growth and roles in multiple biological development and overall processes in brains, such as well-being. neurotransmission and learning and memory. NAD+ Nutrients in oranges are plentiful and NADH may also and diverse. The fruit is low in mediate brain aging calories, contains no saturated fats or cholesterol, but is rich in ===================== dietary fiber, pectin, which is very NAD Energy = Ratio ofeffective in persons with excess body weight. Pectin has also been shown Lactate to Glucoseto reduce blood cholesterol levels by decreasing its re-absorption in the Parkinson's Diseasecolon by binding to bile acids in the colon. Average NAD Level 60 Normal is 100+Orange fruit contains a variety of phytochemicals. Hesperetin and Narigeninare flavonoids found in citrus fruits. Naringenin is found to have a bio-active -------------------------------------effect on human health as antioxidant, free radical scavenger,anti-inflammatory, and immune system modulator. This substance has also Future therapeuticbeen shown to reduce oxidant injury to DNA in vitro studies. intervention that could effectively decelerate theOranges also contain very good levels of vitamin A, and other flavonoid rate of degeneration withinantioxidants such as alpha and beta-carotenes, beta-cryptoxanthin, the substantia nigra parszea-xanthin and lutein. These compounds are known to have antioxidant compacta (SNc) could addproperties. Vitamin A is also required for maintaining healthy mucus years of mobility and reducemembranes and skin and is essential for vision. Consumption of natural morbidity associated withfruits rich in flavonoids helps body to protect from lung and oral cavity Parkinson's disease (PD).cancers.436; 437; 438 While genetic mutations or ===========================oOo========================== environmental toxins can precipitate pathology, Johan's Sushi13 progressive degenerative succession involves a Johan du Buisson------------------------------------- ------------------------------------------------------------269

Sunshine Tour professional gradual decline in DA Johan du Buisson was the neurotransmission/synaptic second Mizuno player to uptake, impaired oxidative break 60 in 2010 with a glucose consumption, a rise course record 59 at his in striatal lactate and chronic home course of De Zalze in inflammation. Stellenbosch, South Africa. Nutraceuticals play a Playing with his MP-58’s, fundamental role in energy MP-630 driver and MP metabolism and signaling Titanium fairway wood in a transduction pathways that mid-week Betterball control neurotransmission Stableford competition (off and inflammation. In the members’ tees) the summary, it is clear that 30-year-old Du Buisson had future research will be three eagles and seven required to consider the multi-faceted nature of thisbirdies in his remarkable 13-under-par round. disease and re-examine how and why the use ofDu Buisson’s round couldn’t quite match the stunning 58 carded by fellow nutritional multi-vitamin-mineral andMizuno player Birgir Hafthorsson - also at his home course in Iceland plant-based combinationsduring September.344 could be used to slow the progression of PD, ifMy Interpretation of Johan du Buisson's Favourite Meal - Seared Beef possible.179Sushi345 =====================Beef NAD Fact Sheet• 1 lb flank steak -------------------------------------• 1 tablespoon peanut oil• 2 tablespoons tamari soy sauce This new work with NAD• 1 tablespoon finely grated fresh ginger Therapy is very exciting and• 1 teaspoon granulated sugar I think is right on target. It is• 2 teaspoons dark sesame oil indeed an NAD Energy• 1 large garlic clove, minced Deficiency (NED) because in the absence of thisSauce coenzyme cycle almost all• 1/2 cup seasoned rice wine vinegar the reactions in the body run• 1/4 cup tamari soy sauce down. Energy is indeed• 2 teaspoons sriracha chili sauce or 2 teaspoons other fiery hot sauce • essential not only to drive our muscles but to digest 2 teaspoons very finely grated fresh ginger our food, even to think andRice• 2 cups sushi rice• 2 cups cold water• 4 tablespoons seasoned rice wine vinegar• 1 pinch saltAssembly• 1/2 ripe avocado• 1 large plum tomato• 1 large green onion• 1 medium carrot8 1 (1 5/8 ounce) package prepared japanese horseradish (43 g, wasabi)• 4 sheets toasted noriDirections:1 To prepare beef, stir soy sauce with sugar, sesame oil, ginger and garlic. Pour over beef; cover and marinate in the refrigerator several hours or overnight. Turn beef at least once during marinating. When ready to sear, heat peanut oil in a heavy frying pan over medium heat. Lift steak from marinade. Discard marinade.2 When oil is very hot, add steak and sear on each side for 5 minutes or until crusty and beef is cooked medium-rare. Remove beef; cool on a plate.3 For sauce, stir rice-wine vinegar with soy sauce, ginger and hot sauce. 270

Beef and sauce can be made a day ahead; cover and refrigerate to feel. separately.4 To make rice, place in a sieve. Wash under cold running tap water until But we will have to rid water runs clear. Drain and place in saucepan with measured water and ourselves of the old a pinch of salt. Soak 30 minutes. Cover and bring to a boil over high vitamin-as-prevention heat. Reduce heat to very low; simmer 15 minutes. Without lifting lid, concept which was so useful remove rice from heat; let stand for another 15 minutes. in helping us isolate the5 For easy cleanup, lightly coat a metal tray with cooking spray; turn rice synthesis of the vitamins. out onto tray. Fan briefly to cool. Gently spread out with a spatula; The old idea that sprinkle with half of vinegar. Using a folding motion, lift rice until liquid is each deficient vitamin absorbed; then add remaining vinegar. Repeat folding and fanning rice causes one deficiency until steam stops rising; cover with a dampened tea towel. Rice can be disease is rapidly being made a couple of hours ahead, however do not refrigerate. buried in the dust bin of6 To assemble rolls, peel, remove stone and thinly slice avocado. Cut medical history.95 tomato in half lengthwise, then use a spoon to remove seeds and ribs, leaving just a shell. Slice tomato lengthwise into thin strips. Diagonally ===================== slice green onion; finely julienne or grate carrot. NAD Energy = Ratio of7 Lay a sheet of nori on a rolling mat or sheet of plastic wrap. Using wet Lactate to Glucose fingers, spread a quarter of the rice over top, leaving 1-inch (2.5-cm) at Peripheral Arterial Occlusive one long end uncovered. About a third of the way from the rice-covered Disease long end, decoratively place together in a long line 2 to 3 strips of beef Average NAD Level 73 and some of prepared avocado, tomato, onion and carrot. Use the mat Normal is 100+ or plastic wrap to help lift and form into a thick roll. When nearly rolled up, wet uncovered nori with wet fingers and finish rolling. Repeat; all the ------------------------------------- assembly ingredients may not be used. Wrap each roll tightly in plastic wrap; refrigerate up to half a day or until needed. The study deals with8 To serve, unwrap rolls. Thinly slice off ends, then cut each roll assessment of the extent of crosswise into 8 pieces. Arrange in a single layer on a plate. Pour sauce tissue ischaemia and into a shallow bowl for dipping. Offer a small dish of wasabi for those disorders of aerobic who like sushi to be truly fiery. metabolism on the basis of comparison of resting===========================oOo========================== arterial, venous values, and the arteriovenous Orange Oil differences in pH, pCO2, pO2, lactate, pyruvate and MIO Smoothie Ingredient glucose levels and the------------------------------------- ------------------------------------------------------------ lactate/pyruvate index in 32 extremities of 16 healthy Orange oil is obtained from the individuals and in 42 peels of orange by cold extremities of 38 patients compression. The main with chronic ischaemic components of this oil are Alpha syndrome of the lower Pinene, Citronellal, Geranial, extremity in stages IIb, III Sabinene, Myrcene, Limonene, and IV according to Linalool and Neral. When you Fontaine. need to cool down after a bad day at the office or suffering from The group of patients inflammation, you need a sedative showed significantly higher to let you relax. The artificial values of lactate, pyruvate, sedatives or drugs available in the glucose and themarket are mostly tranquilizers based on narcotics such as opium and lactate/pyruvate index andsynthetic. These, in the long run, do immense damage to heart and internal lower pH levels thanorgans. Better to follow a natural one like this Orange Oil. It gives relief fromanxiety, anger, depression and inflammations.It gives quick and effective relief from inflammations, internal or externaland caused by any reason such as over intake of spices, fever, infections,side effects of antibiotics, gas, ingestion of toxic substances, narcotics etc.It serves as a detoxifier, boosts immunity, treats constipation and dyspepsiaand is very good for maintaining a healthy, smooth and glamorous skin. Italso helps cure acne and dermatitis.436; 437; 438 ===========================oOo========================== John's Curry13 John Parry------------------------------------- ------------------------------------------------------------271

England’s John Parry has controls. Changes in pCO2, had a great first year on pO2 and pyruvate levels Tour, winning the Vivendi were not significant. Cup before his 24th birthday. Multivariate analysis of data He answered our probing revealed serious impairment questions: of the metabolism of extremities affected by What is your worst trait? I’m chronic ischaemia.180 really lazy. I just can’t be bothered sometimes. When I ===================== go home and my girlfriend NAD Energy = Ratio of wants to go out, I find I’m Lactate to Glucose knackered from the traveling Poisoning and just want to crash out. Is that a bad trait? I’m scruffy -------------------------------------too. My clothes are always strewn around the room and Gary Boyd, myroom mate, is always complaining. Strychnine poisoning results in a predictable andIf you could edit your past what would you change? If I could do anything treatable sequence of eventsdifferent, I’d have started training for golf when I was 13. I didn’t bother until involving blockade of therecently. I’m small but I can hit it 280 yards. I reckon I can get another 15 inhibitory neurotransmitter,yards by getting stronger. extensor muscle spasms, seizures, and respiratoryWhat is your guiltiest pleasure? Curry. I love currys. Chicken Madras, I like paralysis. These spasmsit on the border line to making your sweat. Plain Naan and Mushroom Pilau may lead to hyperthermia,Rice, it never changes. profound lactic acidosis, and rhabdomyolysis. Acidosis isGolf or sex. If you had to give up one, which would it be? I’d give up golf, primarily attributable toyou can always get another job can’t you?346 lactate, as indicated by the correlation between arterialMy Interpretation of John Parry's Favourite Meal - Chicken Madras with pH and log of lactic acidSteamed Basmati Rice347 concentration.Ingredients Serves: 4 Our patient survived, even• 550g Coles chicken thigh fillets, cut in half though at one point he had a• 2 medium field tomatoes, roughly chopped pH of 6.55, a lactate level of• 1 1/2 cup Riviana basmati rice, rinsed 32 mM/liter, a temperature• 1/4 cup coriander, roughly chopped of 43 degrees C, and• 1 brown onion, finely chopped rhabdomyolysis with an• 4 cloves garlic, finely chopped increased creatine• 1 tbsp ginger, finely chopped phosphokinase level of• 1/3 cup TCC coconut milk 359,000 mU/ml (5,983• 1/4 cup Coles olive oil mumol/s/liter).181• 1 cinnamon stick• 8 fresh curry leaves =====================• 1 tsp turmeric NAD Energy = Ratio of• 1 tsp ground cumin Lactate to Glucose• 1 tsp ground coriander Porphyria• 1 tsp garam masala Average NAD Level 69• 1/2 tsp cayenne Normal is 100+Method -------------------------------------1 Heat 2 tablespoons oil in a large saucepan place over medium to high heat. Add onion and cinnamon and cook, stirring frequently, for 3-5 minutes or until golden brown.2 Add the ginger and garlic, and cook for 1 minute. Reduce heat and add turmeric, cumin, coriander, garam masala, cayenne, curry leaves and 1 more teaspoon of oil. Cook for 5 minutes, stirring constantly with wooden spoon and scraping the bottom of the pan.3 Add chicken and cook for 3 minutes, stirring to coat in spice mixture. Add tomatoes and cover. Cook for a further 15 minutes, or until chicken is tender and the tomatoes have broken down and become saucy.4 While chicken is cooking, cook rice according to packet directions.5 Add the coconut milk to the chicken and stir to combine. Simmer for 1-2272

minutes then remove from heat and stir in coriander. Blood lactate concentrations6 To serve divide rice between 4 bowls. Top with the chicken and sauce. after glucose loading were significantly higher in 6===========================oOo========================== patients with acute intermittent porphyria in Pantothenic Acid clinical remission than in 6 control subjects and the MIO Smoothie Ingredient percentage rise in glucose------------------------------------- ------------------------------------------------------------ pyruvate and lactate concentrations were greater Pantothenic acid comes in in the porphyric subjects three forms, and it is alternately than in the control group. known as vitamin B5, pantethine and calcium It is postulated that the pantothenate. Calcium raised lactate levels in the pantothenate is widely used for porphyric patient group may treating ailments from stress to reflect haem deficiency heartburn, while pantethine is affecting the cytochromes of primarily used in lowering blood the terminal respiratory cholesterol levels for those are chain.182 non-responsive to other natural treatments. The primary =====================supplemental form of pantothenic acid is calcium D-pantothenate NAD Energy = Ratio of(D-calcium pantothenate). Pantothenic acid is crucial to numerous activities Lactate to Glucoseof enzymes in the human body. The body utilizes pantothenic acid to Posttraumatic Stressconvert carbohydrates, proteins and fats for energy. -------------------------------------Pantothenic acid works as a constituent of coenzyme A andphosphopantetheine, which are involved in fatty acid metabolism. This The authors administeredvitamin is also responsible in synthesizing numerous enzymes and assists infusions of lactatein maintaining precise communication between the central nervous system intravenously to sevenand the brain. patients with a DSM-III diagnosis of posttraumaticVitamin B5 is of paramount importance for human growth, reproduction and stress disorder, six of whommany normal bodily functions. Vitamin B5 helps breakdown nutrients, also met DSM-III criteria forsynthesize antibodies, and manufacture vitamin D. It also enhances the panic disorder.healing of wounds by significantly lessening the time required for the entirehealing process. Pantothenic acid plays an important role in numerous The lactate infusionsbiological reactions, including the production of energy, the catabolism of resulted in flashbacks in allfatty acids and amino acids, the synthesis of fatty acids, lipids, cholesterol seven patients and panicand steroid hormones, and the production of both coenzyme A, and the attacks in six patients.cellular antioxidant glutathione. The authors conclude thatIt is the most important constituent of coenzyme A, which helps in many with further developmentmetabolic pathways and is required for the transport of fats to and from intravenous lactate infusioncells. Without it, fats could not be metabolized or broken down to energy. In may be used to studyline with this, carbohydrates and proteins are converted to energy, glucose flashbacks and otheris manufactured in the body, fats are broken down, and cholesterol as well dissociative phenomena andas certain necessary hormones are synthesized. to determine the relationship between flashbacks andVitamin B5 is crucial as well to the production of red blood cells as well assex and stress-related hormones produced in the adrenal glands, thosesmall glands that rest above the kidneys. Aside from all those alreadymentioned, Vitamin B5 supplements are sometimes used to help treatsymptoms of allergy and a wide range of skin conditions.436; 437; 438 ========================== =oOo===================== ===== Julien's Sushi13 Julien Guerrier -------------------------------------------- -------------------------------------------- ---------273

Comes from a family with a rich panic anxiety.183 sporting pedigree: grandfather was a fencing world champion; ===================== grandmother played basketball for NAD Energy = Ratio of France; mother played basketball Lactate to Glucose in the French First Division; and Post-Operative Recovery father played football in the French Second Division. ------------------------------------- First took up golf at primary Compared with survivors, school, but initially rebelled the nonsurvivors had higher against the game’s traditions until lactate concentrations onhis teacher – a windsurfer – showed him golf could be “cool”. Soon got admission to the pediatricdown to scratch and enjoyed a superb amateur career, culminating in his intensive care unit at day 1victory at the 2006 Amateur Championship. peak and area under the curve of the lactate profileTurned professional after the Masters Tournament in 2007, but initially than those of adverse andstruggled with his game. Credits his switch to Alain Alberti, who also intact survivors.coaches Raphaël Jacquelin, with his change in fortunes. Was 72nd on the2007 Alps Tour Order of Merit before linking up with Alberti, but won once Significant differences in theand recorded seven top ten finishes in his last eight events to secure time for lactatepromotion to the 2008 Challenge Tour. concentrations to return to 2 mmol/L or less during theCame close to capturing his first Challenge Tour title at the SK Golf first postoperative day wereChallenge, where he lost out in a play-off. But a consistent campaign which observed among the groups:included five top ten finishes meant he took 16th place in the Rankings to nonsurvivors > adverseearn a European Tour card for the first time, and he subsequently improved survivors > intact survivors.his category by taking the 29th card at Qualifying School.348 Lactate concentrations ofMy Interpretation of Julien Guerrier's Favourite Meal349 less than 7 mmol/L on admission or less than 8Ingredients for 1 Tuna Roll: mmol/L at day 1 peak• 1 strip of sushi-grade tuna (about 1/2-inch thick) predicted survival with 82%• 1 strip of blanched red pepper and carrot. sensitivity and 83%• 1 roasted seaweed sheet, specificity, and positive and• 1 handful of cooked sushi rice, negative predictive values of• 1 asparagus spear, 97% and 43%, respectively.• 1 crab stick, Plasma lactateMethod concentrations were1. Place the seaweed sheet on a bamboo sushi mat. ip your hands in a associated with adverse outcome but had lower bowl with cold water with some rice vinegar in it, take the rice and make predictive values compared it into a ball. with that for nonsurvival.1842. Place the ball of rice in the centre of the seaweed sheet and spread it with your fingers, leaving only 1/2-inch of the sheet not covered with rice ===================== at the end. NAD Energy = Ratio of3. Place the other ingredients across the rice in the centre and roll the Lactate to Glucose sushi mat, holding the ingredients with your fingers to stay neatly inside. Premenstrual Syndrome4. Once you roll the tuna roll, hold and squeeze gently the rolled sushi mat to stick the end that haven't been covered with rice. -------------------------------------5. Unfold the mat, place the sushi on a cutting board and cut it to 10 pieces, dipping the knife in the bowl you used for your hands, in order not to stick.6. For the taste of spicy tuna sushi roll, drizzle some sriracha sauce inside the roll over the tuna before closing it. You can, also, use nanami togarashi - spicy Japanese chili mix.===========================oOo========================== Papain MIO Smoothie Ingredient-------------------------------------------------------------------------------------------------274

Exotic papaya fruit or pawpaw is Lactate infusion induced jam-packed with numerous panic attacks in 22 PMS health benefiting nutrients. The subjects (62.9%) and two fruit is one of the favorite of fruit controls (12.5%). Panickers lovers for its nutritional, digestive were equally distributed and medicinal properties. among PMS patients with or Papaya is believed to be a native without a concurrent to Central and South America anxiety/mood disorder. but today it is found in most tropical climates around the Although cardiovascular world. responses to lactate were similar among PMS patientsIndeed, this once very exotic fruit has some very powerful nutritional regardless of the presencebenefits. This low in calories sweet and refreshing fruit is loaded with of concomitant anxiety/moodvitamin A and harbors more vitamin C than the well renowned orange. It disorders, both plasmaalso contains vitamin E, folate, and potassium. Therefore, it contains three cortisol levels and panic andvery powerful antioxidants. mood scores were higher during the test in thosePapaya consists of two very important enzymes called papain and patients with concomitantchymonpapain which help digest protein in the body. However, of the two panic disorder.enzymes, papain is the most abundant and most active enzyme.Nevertheless, these enzymes are most concentrated when the fruit is These results suggest thatpicked green. After picking the powerful duo diminishes as the fruit ripens. PMS patients display anPut simply, it's a great natural digestive aid and it promotes digestive increased sensitivity tohealth.436; 437; 438 lactate, which is not primarily accounted for by the ===========================oOo========================== presence of co-morbid panic disorder.185 Karine's Terrine19 ===================== Karine Icher NAD Energy = Ratio of------------------------------------- ------------------------------------------------------------ Lactate to Glucose Prostate Cancer Karine Icher is a French professional golfer who plays ------------------------------------- mainly on the U.S. based LPGA Tour and is also a member of In biopsies containing the Ladies European Tour. prostate cancer there was a Karine Icher had a successful highly significant (P < amateur career. 0.0001) increase in lactate (1.59 +/- 0.61 mmol/kg) and She was twice Junior alanine (0.26 +/- 0.07 Champion of France winning mmol/kg), and minimal the Girls 15-16 age group in overlap with lactate1994 and the 17-18 age group in 1996. In her 2001 LET rookie season concentrations in benignIcher won two Tournaments, the Palmerston Ladies German Open and the biopsies. This studyMexx Sport Open and finished the year third on the Order of Merit. Icher demonstrates for the firsthad her first child in August 2011. time very low concentrations of lactate and alanine inShe did not play in LET events or in LPGA majors after April 2011. benign prostate biopsyIngredients:• 1/2 pound ground pork• 1/2 pound ground veal• parsley• white bread• milk• whiskyMethod:1. Put 4 slices of white bread into milk. Mash the bread with a fork. Then drain the milk . Put on a side2. Mix the veal and pork, add the bread, add parsley, garlic if you want, and 4 table spoon of whisky.3. Mix everything with hands.4. Salt and pepper275

5. Put everything into a cake pan, 1 hour and 1/2 at 400 degres in oven. tissues.Serve it the day after, keep all night in the fridge. The significant increase inYou can eat it with a green salad. the concentration of both lactate and alanine in biopsybon appetit tissue containing as little as 5% cancer could be===========================oOo========================== exploited in hyperpolarized (13)C spectroscopic imaging Parsley (SI) studies of prostate cancer patients.186 MIO Smoothie Ingredient------------------------------------------------------------------------------------------------- ===================== NAD Energy = Ratio of Parsley herb is popularly used as a Lactate to Glucose culinary spice, however, it has many Psoriasis health benefits that most of us are Average NAD Level 89 unaware of. Parsley has been Normal is 100+ grown for more than two thousand years and it has been used for its ------------------------------------- curative properties much before it was used as a spice in the kitchen. The aim of the study was to The leaves of this herb are aromatic examine the effectiveness of in nature and are often used to the oxidized form of flavor many dishes. Parsley has nicotinamide adeninemany health benefits as well. Having parsley is helpful as it stimulates dinucleotide (NAD(+)),digestion of protein as well as fat. adenosine precursor, in 37 patients suffering fromParsley is rich in Vitamin B12, Vitamin C, Vitamin K, Vitamin A as well as psoriasis. As NAD(+) isBeta Carotene. Apart from the mentioned vitamins this herb is also a good known to be relativelysource of folic acid as well as iron. Parsley is a power plant of chlorophyll, unstable, the second goalthis helps curb the growth of bad bacteria as it has anti bacterial properties. was to establish the properChlorophyll found in parsley is a good cure to stop and avoid bad breath. conditions for the satisfactory stability ofParsley contains many health benefiting essential volatile oils that include topical NAD(+) composition.myristicin, limonene, eugenol, and alpha-thujene. The essential oil,Eugenol, present in this herb has been in therapeutic use in dentistry as a After a 4-week application,local anesthetic and anti-septic agent for teeth and gum diseases. Eugenol the reduction in erythema,has also been found to reduce blood sugar levels in diabetics, however, infiltration and desquamationfurther detailed studies required to establish its role. Parsley is rich in caused by 1 or 0.3% topicalpoly-phenolic flavonoid anti-oxidants including apiin, apigenin, crisoeriol, NAD(+) composition wasand luteolin; and has been rated as one of the plant source with highest similar to the reductionanti-oxidant activities. caused by 0.1% anthralin. NAD(+) therapy combinesParsley herb has some oils such as myristicin, limonene, eugenol as well as good efficacy, cosmeticalpha thujene which are antioxidants in nature. The above mentioned oils acceptability and convenientcounterbalances the effects of some carcinogens and reduces the chances twice-daily application.187of getting cancer. The oil of parsley herb is a good remedy for hair loss aswell as dryness of the skin.436; 437; 438 ===================== NAD Energy = Ratio of ========================= Lactate to Glucose ==oOo==================== Pulmonary Emphysema ====== Kim's Bro Shrimp19 Kim Shipman ------------------------------------------- ------------------------------------------- -----------276

You won't find fur head covers Average NAD Level 74 on clubs that belong to Kim Normal is 100+ Shipman. You might find a sticker on her belongings that ------------------------------------- says, \"Love Animals, Don't Eat Them.\" You won't see Shipman Since Glu is an important with one of those deep-dark substrate in the synthesis of tans--the kind that look glutamine (Gln) and wonderful at 28 and woeful at glutathione (GSH), the 55. You will find her wearing influence of Glu status onsunscreen, and endorsing a brand that does not use animals in testing. muscle GSH and Gln wasShipman, 28, strays a bit from the LPGA norm. also examined. In 13 patients with emphysemaAs the head of Kim Shipman's driver smashes into the golf ball, a primal and 25 control patients,grunt or moan drifts over the first tee. The noise seems strangely out of arterial blood and biopsiesplace in the posh setting of a fine golf course. It is the type of sound you from the vastus lateraliswould expect to hear as a 350-pound truck driver attempts to squeeze muscle were obtained.behind the wheel of his big rig. Shipman relaxes and watches the flight ofthe ball.350 Expressed as a percentage of the control values, theI make this for my friend Larry, the 'handy man' as an afternoon snack patients with emphysemawhen he is working, I walk down to the docks where the shrimp boats come had reduced values forin and get a bag full for the two of us. muscle Glu (64 +/- 12%; p < 0.001), GSH (76 +/- 23%; pMethod: < 0.01), and Gln (93 +/- 5%;1. Fresh large peeled and deveined shrimp. (1.5 - 2 pounds) (a shrimp p < 0.01), and higher values for lactate (p < 0.01) and peeler/deveiner is a must at $2-and if you don't have one, use the tong pyruvate (p < 0.05). No of a fork. Enter at the head end just below the shell where the vein is. differences were found in Work the instrument all the way down to the tail and keep pushing. The plasma values. shell comes off and it dislodges the vein, so you can grab the vein with a paper towel (they are sticky) or it just comes off with the shell. VERY This study illustrates that easy operation and a great time saver.) reduced Glu levels in2. Cook the shrimp at a low to medium heat- don't boil. This is the trick to skeletal muscle of patients keeping them plump and juicy. Make sure all sides are pink and no gray with emphysema are left on the shrimp. possibly related to an3. In a separate pan, melt half to whole stick of unsalted butter, 2 enhanced glycolytic activity tablespoons of Worchistire sauce, 4 tablespoons Old Bay seasoning, 2 and associated with Tabllespoons Texas Pete hot sauce. All to taste. decreased GSH levels.1884. Use some sauce to toss and coat the shrimp and save the rest to dip. (I use little pickle forks that have clam shells as handles and put the ===================== dipping sauce in a sea shell styled ramican) NAD Energy = Ratio of5. Serve with ice cold Budweiser! Lactate to Glucose Religious AddictionServe what is left over with rice or pasta. Average NAD Level 62 Normal is 100+===========================oOo========================== ------------------------------------- Passion Flower MIO Smoothie Ingredient------------------------------------- ------------------------------------------------------------Passion flower extracts or Passiflora Incarnata is a great herb that iscommonly used to reduce anxiety and stress. The bright beautiful coloredflowers with blue, violet, yellow petals are not only beautiful but also workwonder in combatting occasional panic, body pain and trouble sleeping. Doctors have also found passion flower extracts effective in improving blood circulation.277

Stress is one of the several causes behind gaining weight. The life style, hectic schedule and daily pressure give rise to Cortisol which encourages calories to be stagnant. It harasses the brain cells and often the sleep at night is disturbed. Passion flower extracts soothes the central nervous system and calms the brain to have a sound sleep. Elements like amino acid, sterol inpassiflora herb burns the calories by enhancing metabolism.351 ===========================oOo========================== Moral or religious scrupulosity is a disabling Kirby’s Naan Bread Pizza19 condition which is sometimes seen in patients Kirby Dreher with obsessive compulsive------------------------------------------------------------------------------------------------- disorder (OCD). The authors described 10 patients with Since my last blog about moral or religious making it to the US Women’s scrupulosity who were Open, I played in the US treated with fluoxetine or Women’s Open at Oakmont clomipramine. Country Club in Pittsburgh and I also Monday qualified for the Seven of the 10 patients Canadian Women’s Open in completed open treatment of Winnipeg, Manitoba. I had an at least 8 weeks without absolute blast playing in these requiring adjunctive 2 huge LPGA events and medication; 5 of those 7 really believe that I belong out patients were rated as much there! improved. Among the 3 patients who requiredI also played the rest of the Duramed Futures Tour events, I did ok but still adjunctive medication, 1 waswas not satisfied with my overall result on the tour. I am extremely happy rated as much improved.that I got the opportunity to play on the Futures Tour and it taught me somuch about myself as a golfer and about what to expect in the future and Of the 4 nonresponders at 3also taught me a lot about myself as a person. I learned how to try and stay months, 2 responded afterorganized, frugal, independent, driven, and how to stay focused while on longer treatment trials.the road for 7 months straight! Living out of a suitcase isn’t the most fun These results suggest thatpart about this job but overall it was a great experience.352 extreme moral or religious concerns and behaviorsYou need: might be a form of OCD and• Whole wheat, garlic, or regular naan bread. that the scrupulosity can be• Olive Oil effectively treated with• Minced garlic serotonin reuptake• Roma Tomatoes blockers.189• Cilantro• Fresh mozzarella =====================• Italian seasoning NAD Energy = Ratio of Lactate to GlucosePre-heat the oven to 400F Rett Syndrome1 Rub some olive oil on the naan bread and spread it out evenly. Add ------------------------------------- some minced garlic after the olive oil is down so it has something to stick to(use as much or as little garlic as you'd like)2 Add slices of the Roma tomatoes as well as slices of the fresh mozzarella all over the bread. Use as little or as much of these 2 ingredients as you would like!3 Add the Cilantro and Italian seasoning for extra flavor and garnish.4 For best results pop into the oven on a pizza stone for about 8 minutes. If you do not have a pizza stone a baking sheet will work just fine!You can obviously make this type of pizza with whatever ingredients youdesire! I prefer a pizza without any pizza sauce and I like how it's light, freshand very tasty!278

===========================oOo========================== We investigated both blood and cerebrospinal fluid Pea Protein (CSF) lactate and pyruvate levels in seven girls with the MIO Smoothie Ingredient Rett syndrome (RS) and------------------------------------- ------------------------------------------------------------ evaluated the relationship between CSF lactate and New research from Canada pyruvate levels and the found that proteins in the clinical manifestations, common garden pea may particularly seizures, provide a natural remedy anticonvulsant medication, against high blood pressure and and breathing dysfunction chronic kidney disease (CKD). including breath holding, The pea protein could be used apnea and hyperventilation. as a natural food product such as an additive or dietary Elevated lactate and supplement to help the millions pyruvate levels in CSF with of people worldwide that suffer normal serum lactate werefrom these conditions, suggested the researchers. The 100% Pure Pea found in two RS patients.Protein formula... Elevated CSF lactate correlated significantly withProvides you 100% pure protein from a natural source -- yellow peas the clinical occurrence of hyperventilation. An elevatedDelivers you an allergen-free and non-GM source of protein lactate level may be a clue to clarify the etiology ofLeaves you no excuses to skip breakfast again -- easy to mix into a quick RS.190meal when you're pressed for time =====================Creates an excellent complement to Whey Protein Powder -- helps you NAD Energy = Ratio ofavoid potential allergen issues as you rotate between the two protein mixes Lactate to Glucose Reye's SyndromeDelivers you a pleasing, neutral taste -- without artificial flavors -------------------------------------Provides you an easily absorbable protein that's gentle on your stomach We compared the levels ofBoosts your pre-workout energy level and helps your muscles recover after hormones and metabolitesexercising -- provides special essential amino acids in the plasma of 37 survivors of Reye's syndrome with thePotentially aids you in feeling full after eating -- could help your weight levels in 8 fatal cases, atmanagement together with eating healthy and exercising four time periods within 72 hours of admission. TheUses environment friendly harvesting and production processes most prominent differences were found forUses a mild, proprietary process without chemical solvents to deliver the norepinephrine (NE), whichpea protein nutritional value to you was significantly elevated in fatal cases compared withDelivers you a high-quality, consistent protein source from rigorous survivors at all periods.production and standard processing practices353; 354 Lactate and dopamine were ===========================oOo========================== elevated in the earlier periods. Skeletal muscle Lien's Pasta with Truffle19 Lien Willems------------------------------------- ------------------------------------------------------------279

My game has improved, ischemia from NE-induced distance is back and I know vasoconstriction may explain that my putts will drop if I’m the association between patient. I could use the lactic acidemia and the trackman from Caroline Harper severity of and Paul Hansen to set my encephalopathy.191 distances correct so now it’s practice and play some club ===================== competitions to keep the rythm. NAD Energy = Ratio of Also strenght and condition Lactate to Glucose training and a bit of work. Schizophrenia Average NAD Level 60 -I spent the last weeks practicing, playing, doing my physical excersises and Normal is 100+a bit of work. I made some changes in my swing, set up, short game andputting. I have new physical excersises and I’m working on my mental. A lot -------------------------------------of things, but sometimes it’s one step back to put a big one forward…I’vebuilt a good team around me and I would like to thank them.355 Evidence is accumulating that mitochondrialMy favourite dish is Pasta with truffle, truffle oil, mushrooms and parmesan dysfunction is involved in thecheese.356 pathophysiology of bipolar disorder and schizophrenia.My Interpretation of Lien Willems's Favourite Meal Cerebrospinal fluid (CSF) concentration of lactate, aIngredients: product of• 2 tablespoons unsalted butter extra-mitochondrial glucose• 2 tablespoons shallots, minced metabolism, is commonly• 2 tablespoons truffle butter or truffle paste elevated in individuals with• Truffle shavings, or fresh Truffle mitochondrial disorders,• 8 ounces fresh fettucine especially those with• 1/2 to 1 cup heavy cream neuropsychiatric symptoms.• truffle oil• mushrooms This is the first report of• parmesan cheese increased CSF lactate concentrations in patientsDirections with bipolar disorder and1 Bring salted water to a boil. schizophrenia. Elevated2 Meanwhile cook shallots in butter over very low heat or until tender. Add CSF lactate indicates increased heavy cream and reduce somewhat or until thickened. extra-mitochondrial and3 Cook pasta for 2 minutes or until al dente and add to cream; toss to anaerobic glucose metabolism and is coat. consistent with impaired4 Whisk in truffle butter or paste into pasta and remove from heat. mitochondrial metabolism.5 Season with salt.6 Serve with truffle oil, mushrooms, parmesan cheese.and truffle Measuring CSF lactate concentration might help shavings or fresh truffle. identify bipolar and schizophrenic patients with===========================oOo========================== mitochondrial dysfunction who might benefit from Pear research to elucidate and ultimately rectify possible MIO Smoothie Ingredient-------------------------------------------------------------------------------------------------Mildly sweet and rich in flavor pears offer crunchiness of apples yet juicy aspeach and nectarine. This simple fruit is widely popular, especially in thewhole of northern hemisphere, for its unique nutrient qualities. Pear fruit ispacked with health benefiting nutrients such as dietary fiber, anti-oxidants, minerals and vitamins which are necessary for optimum health.280

Pears provide about 3.1 g of mitochondrial pathology dietary fiber per 100g. Regular underlying these eating of pears may offer disorders.192 protection against colon cancer. Also, the gritty fiber content binds ===================== to cancer causing toxins and NAD Fact Sheet chemicals in the colon, protecting its mucous membrane from ------------------------------------- contact with these compounds. Fatigue is a prominent In addition, pear fruit is one of the disabling symptom in a very low calorie fruits, just variety of medical andprovides 58 cal per 100g. Just a few sections a day in the diet can bring neurologic disorders. Thesignificant reduction in weight and blood LDL cholesterol levels. Pears familiar example of howhave suggested being useful in treating colitis, chronic gallbladder white light viewed through adisorders, arthritis and gout.436; 437; 438 prism, splits into the colours of a rainbow is a good===========================oOo========================== analogy of what is meant. Louis' Oats and Banana19 NAD Energy Deficiency can be viewed as a form of a Louis Le Grange spectrum disorder. In other------------------------------------- ------------------------------------------------------------ words, one common cause (NAD Energy Deficiency) Louis Le Grange Student at can cause, maintain or Stellenbosch Born 1991 contribute to a variety of disorders. Method: All cells, tissues, organs and 1 1 hour before golf i drink two systems in our bodies need glasses of water, eat a bowl of energy to function optimally. oats and a banana. An NAD Energy Deficiency can cause, depending on the 2 During the round I hydrate the cell location, various whole time and eat biltong and symptoms and disorders peanuts for stamina en energy. ranging from cell death to death itself.143 Before a big Tournament I carbaload two days before eating alot of pasta. ===================== NAD Energy = Ratio of===========================oOo========================== Lactate to Glucose Pine Bark Extract Seasonal Affective Disorder - Average NAD Level 53 - MIO Smoothie Ingredient Normal is 100+------------------------------------- ------------------------------------------------------------ ------------------------------------- Pine Bark Extract, another name for proanthocyanidin, is a bioflavanoid complex extracted from the bark of Pinus Massoniana Lamb. It is a powerful antioxidant, and is being studied as a treatment for disorders caused by free radicals, including Alzheimers, cancer, macular degeneration, glaucoma, and senility. Antioxidants play a crucialrole in repairing and protecting cells in the body. They help shield againstfree radicals, which are harmful byproducts of metabolism and exposure toenvironmental pollutants.Free radical damage is believed to contribute to aging, as well as to severeconditions including heart disease and cancer. Popular antioxidants includevitamin A, vitamin C, vitamin E, and the mineral selenium. Researchershave termed the group of antioxidants found in pine bark extract oligomericproanthocyanidins, or simply OPCs. OPCs (also referred to as PCOs) aresome of the most potent antioxidants available.There is strong evidence that Pine Bark Extract can improve the circulatorysystem by helping to strengthen capillaries and veins. Improved circulationhelps fight both cardiovascular disease and Chronic Venous Insufficiency281

(CVI), a circulatory disorder characterized by itching skin, swelling, ulcers, The serotonin and circadianedema, and varicose veins. In addition, Pine Bark Extract keeps blood systems are principalplatelets from sticking together and forming hazardous blood clots. Some regulatory networks of thestudies have shown that Pine Bark Extract eases allergic or inflammatory brain. Each consists of asymptoms by inhibiting the release and synthesis of certain compounds that unique set of neurons thatpromote inflammation, such as histamine, serine protease, prostaglandins, make widespread neuraland leukotrienes. Pine Bark Extract may also help heal stress-related ulcers connections and a definedby reducing histamine secretion and by binding to and protecting connective gene network oftissue in mucous membranes. transcriptional regulators and signaling genes thatPine Bark Extract is used in chronic venous deficiency, allergies, asthma, subserve serotonergic andhypertension, muscle soreness, pain, osteoarthritis, diabetes, attention circadian function at thedeficit-hyperactivity disorder (ADHD), endometriosis, menopausal genetic level.symptoms, dysmenorrhea, erectile dysfunction, and retinopathy. It is alsoutilized preventing stroke, cardiovascular conditions such as heart disease These master regulatoryand varicose veins, as well as in slowing the aging process, maintaining networks of the brain areskin health, and improving athletic endurance and sperm morphology.436; 437; extensively intertwined, with reciprocal circuit438 connections, expression of key genetic elements for ===========================oOo========================== serotonin signaling in clock neurons and expression of Lynn's Toad-In-The-Hole19 key clock genes in serotonergic neurons. Lynn Kenny------------------------------------------------------------------------------------------------- The reciprocal connections of the serotonin and But after five years teeing off circadian systems likely against Europe’s elite, including have importance for the great Annika Sorenstam and neurobehavioral disorders, Women’s Open champion and as suggested by their countrywoman Catriona Matthew, convergent contribution to a she is candid about her progress similar range of mood as a professional, having finished disorders including seasonal the 2009 season in mid-table. affective disorder (SAD), bipolar disorder, and major “I look around me, and I am stuck depression, and as in the trap of admiring the people suggested by theiraround me and thinking that they are better than me. I did that as an overlapping relationship withamateur until I had my breakthrough at the Ladies’ Amateur Championship the developmental disorder,in 2000. autism spectrum disorder.193“Mostly it’s great being a pro. I’ve got a good bunch of friends on the Tour =====================who I hang about with. We’re all desperate for each other to do well – NAD Energy = Ratio ofwe’re a hard working group of friends. Lactate to Glucose Sex Addiction“But I’m going to make an effort next year to see the places I go to a lot Average NAD Level 60more. I was in Rome three times and never once went into town to see Normal is 100+everything, even though we were only five minutes from the city centre. Iguess I was worried about breaking my concentration and tiring myself out. -------------------------------------I need to rest up. Maybe I’ll regret it when I’m 50!”357So for Toad-In-The-Hole, it's more of a \"heat things up\" kind of recipe.Ingredients:• 1 x small onion• 3 x potatoes (for boiling)• 4-6 x sausages (I like skinless, but it can be any kind)• 1 x Large Yorkshire Pudding (I buy them frozen in supermarket, but I'm sure there is a recipe for them?)• 1 x portion of frozen garden peas/petit pois• Bisto Gravy GranulesMethod:1 First of all, I peel and cut the potatoes and put them in water - bring them to boil for 10-15 mins (until soft for mashing).2 Put peas in boiling water and bring back to boil for 6-8 mins.282

3 I put the sausages on my George Foreman Grill, but you can fry them Trust is a huge issue for alongside the onions in the next step: these women, and even when taking a positive risk in4 I cut the onion and put it in a frying pan with a little oil (add sausages therapy, trauma responses and cook them thoroughly - I add the sausages from the foreman grill). from early childhood may be evoked. These women are5 Prepare Bisto gravy, approx 300ml? and add to the onions and exquisitely sensitive to sausages once they are cooked. criticism, but if feeling safe most can learn to trust and6 Leave to simmer while you mash the potatoes. will respond to help,7 Put the yorkshire pudding in the oven for the required time (5-6 mins because they long to be restored to their values, be usually). self-sufficient, and have a8 Once the potatoes have been mashed (add cream/butter to taste) place voice that is respected. them into the middle of the large yorkshire pudding. Uncovering sexual secrets9 Add the sausages/onions/gravy and then put the peas on top to finish. from previous generations, still present in theVoila - a good scottish stodgy meal!! Great for cold winter's nights after a families-of-origin, helpslong day practising!! patients put their problems in context. Treatment can be===========================oOo========================== successful if patients develop a capacity to bond, Pomegranate can tolerate the psychic pain of disclosure, are willing to MIO Smoothie Ingredient be accountable, are resilient,------------------------------------- ------------------------------------------------------------ and can forgive themselves and others. The rewards for Pomegranate is among the most this endeavor are great.194 popular, nutritionally rich fruit with unique flavor, taste, and heath ===================== promoting qualities making it a NAD Energy = Ratio of common ingredient in new Lactate to Glucose functional foods often called Self-mutilation “super fruits”. Pomegranate is one Average NAD Level 53 of the most extensively cultivated Normal is 100+ fruits for food, juice, flavor, and color, making it a common ------------------------------------- ingredient in new functional foodsoften called “super-fruits”. An association between serotonin (5-HT) activity andThe fruit is good in calories and contain no saturated fats; but contain self-injurious (i.e.,numerous health promoting anti-oxidants, minerals and vitamins. self-aggressive) behaviorLaboratory research suggests, polyphenolic anti-oxidant compound, across the spectrum ofpunicalagin in the pomegranate juice is effective in reducing heart disease lethality (from self-mutilationrisk factors, by scavenging harmful free radicals from the body. through completed suicide) is a well-replicated finding.It is rich source of soluble and insoluble dietary fibers, providing about 4 gper 100 g (about 12% of RDA), which are known to help regulate the Tryptophan depletionfunctioning of the digestive system and smoothen constipation conditions. It facilitated selection of moreis therefore, this fruit is suggested in the diet for weight reduction and intense shocks, on average,cholesterol controlling programs. Regular inclusion of fiber fruits in the diet in both groups. Patients withhelps protect from colon cancers.Regular consumption of pomegranate has also been found to be effectiveagainst prostate cancer, benign prostatic hyperplasia, diabetes, andlymphoma. It is also good source of many vital B-complex group ofvitamins such as pantothenic acid (vitamin B-5), folates, pyridoxine andvitamin K, and also minerals like calcium, copper, potassium andmanganese.436; 437; 438===========================oOo========================== Maarten's Spaghetti Bolognese13 Maarten Lafeber------------------------------------- ------------------------------------------------------------283

Maarten Lafeber is a IED were also more Dutch professional golfer self-aggressive overall than who won the Dutch, Swiss healthy volunteers. and Spanish amateur Experimentally lowered 5-HT championships before bioavailability enhances turning professional in overall self-injurious 1997. behavior irrespective of aggression history.195 Lafeber was born in Eindhoven, ===================== Noord-Brabant. He earned NAD Energy = Ratio of a European Tour card at Lactate to Glucose the first attempt, but lost it Sickle Cell Disease at the end of 1998. After spending time on the ------------------------------------- second tier ChallengeTour, where he won the 1999 Tusker Kenya Open, he regained his place This prospective study wason the main tour for the 2000 season. In 2003 he became the first home carried out to assess lactateplayer to win the KLM (Dutch) Open since Joop Rühl 1947, and that dehydrogenase (LDH) as aremains his only win on the European Tour. biochemical marker during acute painful episode andLafeber set himself apart from many other golfers when, before his steady state in children withEuropean Golf Tour season in 1998, he sold shares in himself to a group of sickle cell disease (SCD).businessman. He used the cash to finish his Tournaments for that season.While he struggled that year, he repaid the shareholders after the 2004 LDH has been found toseason at a profit to them of 85 percent per share.358 increase significantly during acute painful episodeMy Interpretation of Maarten Lafeber's Favourite Meal - Chef Anne Burrell’s compared with steady state.Spaghetti Bolognese359 There is also a significant positive correlation betweenIngredients: LDH level and severity of• 3 pounds of ground chuck, brisket or round (I combined 2.2lbs 96/4 lean pain. In addition, C-reactive protein level was found to be ground beef with 1lb 80/20 ground chuck) significantly elevated during• High quality extra-virgin olive oil, for finishing acute painful episode and its• 1 large onion or 2 small, cut into 1-inch dice level correlates significantly• Kosher salt (lots and lots of Kosher salt!) with severity of pain.196• 2 large carrots, cut into 1-inch dice• 1/2 cup grated Parmigiano-Reggiano =====================• 3 ribs celery, cut into 1-inch dice NAD Energy = Ratio of• 1 bunch thyme, tied in a bundle Lactate to Glucose• Extra-virgin olive oil, for the pan Skin Cancer• 3 cups hearty red wine• 4 cloves garlic -------------------------------------• 2 cups tomato paste• Water• 3 Bay leaves• 1 pound spaghettiPreparation:1 Puree the onion, celery, carrots, and garlic in a food processor. Put the puree in a bowl2 Cover the bottom of a heavy, very large skillet (or cast iron dutch oven) with olive oil over medium heat.3 Turn the heat to medium-high and brown the veggies. Season generously with salt. By generously, like 2 tablespoons or more of kosher salt. It looks like a lot, but Kosher salt is a coarser, less purified salt so it can take more Kosher salt to season, plus you’re making A LOT of food with this dish. So don’t hold back on the salt. This is where big flavors develop, according to Chef Anne. You have to season during the entire cooking process, not just right at the end. Cook the veggies until all of the water has evaporated from the pan.4 This is the time to get your beef out and get it ready for browning. Add the beef and season generously with salt again. Keep stirring and churning so all of the beef gets cooked evenly and mixes well with the284

veggies. The maintenance and5 Once the beef is almost done, take out the tomato paste and open the regulation of cellular NAD(P)(H) content and its cans so you can add it right away. Also, make sure you open your wine influence on cell function bottle since you add the wine right after the tomato paste. involves many metabolic6 Add the tomato paste and let it brown. Stir well and brown pathways, some of which7 Add the wine. Cook until the wine has reduced by half, another 4-5 remain poorly understood. minutes. Niacin deficiency in humans,8 Add water to the pan until the water is about 1 inch above the meat. which leads to low NAD Toss in the thyme bundle and the bay leaves. status, causes sun9 Bring to a boil and reduce to a simmer, stirring occasionally. As the sensitivity in skin, indicative water evaporates, you’ll gradually need to add more, 2 or 3 cups at a of deficiencies in responding time. Just keep simmering. Stir every now and then, since wine and fat to UV damage. from the meat tends to congregate on the top and you want to make sure they’re absorbed in the cooking proce Sirtuins are inhibited by the10 About 30 minutes before your sauce is done, bring a large pot of salted unavailability of their water to a boil and cook the spaghetti for 1 minute less than it calls for substrate, NAD+, leading to on the package. Remove half of the bolognese and reserve in a serving unrepaired DNA damage bowl. Add the spaghetti, reserving 1/2 cup of the pasta water if needed. upon photodamage and a11 Use tongs to toss the pasta with the remaining half of the bolognese. subsequent increase in cell Add the reserved pasta water and stir, cooking over medium heat until death. the water has reduced.12 Turn off the heat, give a big sprinkle of Parmigiano-Reggiano and a Furthermore, the generous drizzle with high quality finishing olive oil. identification of the nicotinic acid receptor in human skinPut your spaghetti in bowls to serve and enjoy! keratinocytes provides a further link to niacin's role as===========================oOo========================== a potential skin cancer prevention agent and Pyridoxine suggests the nicotinic acid receptor as a potential target MIO Smoothie Ingredient for skin cancer prevention------------------------------------- ------------------------------------------------------------ agents.197 Vitamin B6 (Pyridoxine) is a ===================== very important B vitamin for NAD Energy = Ratio of most people, but it is Lactate to Glucose especially vital for women. It Stress and Burnout - seems to be directly related Average NAD Level 74 - and connected to hormone Normal is 100+ balance and water shifts in women. Vitamin B6 is made ------------------------------------- up of three related compounds, all of which can The maintenance and be found in food, namely regulation of cellular pyridoxine, pyridoxal, and NAD(P)(H) content and itspyridoxamine. The predominant biologically active form is Pyridoxal. influence on cell functionHowever, pyridoxine is the form used in vitamin supplements because it is involves many metabolicthe least expensive to produce commercially. Vitamin B6 is stable in acid, pathways, some of whichand is fairly easily destroyed with ultraviolet light, for example sunlight, and remain poorly understood.during the processing of food. It is also lost in cooking or refining, as well as Niacin deficiency in humans,with improper food storage.Pyridoxine and its coenzyme form, pyridoxal-5-phosphate, have a multitudeof metabolic functions in the body, especially in amino acid metabolism andin the central nervous system, where it supports production ofgamma-aminobutyric acid (GABA). Many reactions, including theconversion of tryptophan to niacin and arachidonic acid to prostaglandin E2,need vitamin B6. The pyridoxal group is beneficial in the utilization of allfood sources for energy and in facilitating the release of glycogen (storedenergy) from the liver and muscles. It assists as well in the production ofantibody and red blood cell (hemoglobin synthesis) as well, and in thesynthesis and functioning of both DNA and RNA. By helping manage thebalance of sodium and potassium in the body, vitamin B6 is crucial in thefluid balance regulation and the electrical functioning of the nerves, heart,and musculoskeletal system.Pyridoxine is especially important with respect to protein metabolism. Many285

amino acid reactions rely on vitamin B6 to help get amino acids across the which leads to low NADintestinal mucosa into the blood and from the blood into cells. By itself and status, causes sunwith other enzymes, pyridoxal-5-phosphate helps build amino acids, break sensitivity in skin, indicativethem down, and change one to another and is especially related to the of deficiencies in respondingproduction and metabolism of choline, methionine, serine, cysteine, to UV damage.tryptophan, and niacin. During pregnancy, the body has a high requirementfor vitamin B6. It is important for maintaining hormonal and fluid balance of Sirtuins are inhibited by thethe mother and for the developing nervous system of the baby. Pyridoxine unavailability of theirmay somehow be related to the development and health of the myelin substrate, NAD+, leading tocovering of the nerves, which allows them to conduct impulses properly. unrepaired DNA damage upon photodamage and aVitamin B6 is used for people with stress conditions, fatigue, headaches, subsequent increase in cellnervous disorders, anemia, and low blood sugar or diabetes, and in men for death.prostatitis, low sex drive, or hair loss. Pyridoxal-5-phosphate (P5P) isoccasionally used in formulas or as an individual supplement for certain Furthermore, theconditions. As the active coenzyme of pyridoxine, P5P can go more directly identification of the nicotinicinto the metabolic cycles and does not have to be converted; thus, it may acid receptor in human skinbe more helpful than pyridoxine alone in such problems as fatigue, keratinocytes provides aallergies, viral disease, chemical sensitivities, mental illness, and cancer. further link to niacin's role asPyridoxine supplementation is also used for a variety of skin a potential skin cancerproblems--dandruff, eczema, dermatitis, and psoriasis. In regard to the prevention agent andnervous system, vitamin B6 has been supportive in cases of epilepsy, suggests the nicotinic acidParkinson's disease, multiple sclerosis, and neuritis. Vitamin B6 therapy, receptor as a potential targetfrom 100-300 mg. daily for 8-12 weeks, appears to reduce carpal tunnel for skin cancer preventionsyndrome and increase the ability to use the hands in most patients.436; 437; agents.198438 ===================== NAD Fact Sheet===========================oOo========================== ------------------------------------- Matia's Pasta19 Critics may proclaim that it is Matia Maffiuletti impossible to discover a------------------------------------------------------------------------------------------------- single drug or supplement that could benefit such a Has merit in a push to run a diverse number of medical circuit of golf in general, but conditions. According to the one female in particular. In my standard pharmaceutical humble understanding of the paradigm, a drug is female golf is the area with the designed to carry out a highest projection in the specific action to modify a medium term and where disease state and bring investments can still get symptoms under control. sponsorship to be profitable. In the case of NAD, Today has been a little fun mitochondrial energy“Pachanga” in 3 pairs of communication between people and players. I had inefficiency is the commonthe opportunity to play with you Matia Maffiuletti Unlike a lot of tour players biological pathwaywith an online presence, careful, business card design, facebook profile, influencing many clinicaletc.. conditions including optimal muscle physiology,That bring new airs … these girls golf. Probably one of the best things that satisfactory digestion andcan happen to this sport is the massive irruption of women on a assimilation of food, optimalprofessional level … also sure some “cobwebs” and costrumbres ancestralfinally fall.360I've to confess that I love cooking all kind of dish.. but my favourite one ispasta with fresh tomato and mozzarella.Method:You just need for 4 people1. 350 gr of short pasta, I really like \"fusilli\" put them in boiling salted water and respect the time indicated on the box, it will be approximatly 10 minutes.2. For the sauce you have to take 3 fresh tomatoes, cutted and pealed put them in a casserole with two spoons of olive oil cutted onion and leaves286

of basil and leave it on fire for some minutes. brain function and mood3. Cut the mozzarella in pieces. when the pasta is ready take off the water control and many more physiological processes in and add the pasta to the sauce and leave them together in the the body. casserole for some minutes to take the flavour.4. Put the pasta in the dishes and put on the top some pieces of Multiplicity of symptoms and mozzarella and leaves of basil. a large list of potential5. Your dish is ready to be served. So easy so fast and really really good! diagnoses should not imply that the condition is notAs a dessert I can suggest my favourite one that is gelato!! caused or exacerbated by a single deficiency.20To prepare stracciatella ice cream you need: =====================• 100 gr of sugar NAD Energy = Ratio of• 200 gr fresch cream Lactate to Glucose• 100gr darck chocolate Stroke• 4 eggs Average NAD Level 88 Normal is 100+Method:1 Mixing 4 yolks with the sugar. In another bowl shake the white of the ------------------------------------- eggs and separatly shake the fresh cream till it will be foamy. Multiple studies have also2 Cut the chocolate in pieces and add it to the first mixture add the white suggested that NAD+ depletion mediates PARP-1 eggs and finally the cream. cytotoxicity, and NAD+3 Now with a spoon mix all the ingredients and pour the mixture in a administration can decrease ischemic brain injury. A silicone stamp for plume cake. number of recent studies4 Put it in the frezeer and let it inside for some hours before serve it! have provided novel information regarding theIt's delicious!! mechanisms underlying the roles of oxidative stress and===========================oOo========================== NAD+-dependent enzymes in ischemic brain injury Resveratrol It is increasingly likely that MIO Smoothie Ingredient future studies on NAD- and------------------------------------- ------------------------------------------------------------ NADPdependent enzymes, such as NADPH oxidase, Red wine has about 1.5 to 3 PARP-1, and sirtuins, would milligrams of resveratrol per expose novel mechanisms liter. This natural supplement underlying the roles of can cause large and oxidative stress in cerebral permanent weight loss. ischemia, and suggest new Resveratrol acts to improve therapeutic strategies for the metabolism on a cellular treating the debilitating level, which results in the more disease.199 efficient burning of fat. Resveratrol also aids for the ===================== regulation of the blood sugar NAD Energy = Ratio of levels. In this way the Lactate to Glucose nutritional chemical Testicular Cancersubstances that we receive with the food are processed more efficiently. As Average NAD Level 77a result you will feel more energetic despite the slimming process takingplace.Furthermore, the appetite is more balanced, which will reduce the naturalcraving for food. One of the most highly appreciated effects of Resveratrolis its anti-aging effects most evident on the skin. Resveratrol activates acell's survival defense enzyme, which prolongs the time cells have to repairtheir broken DNA. With the improved production of elastin and collagencells the skin becomes softer and more elastic. The appearance of wrinklesis prevented or if they have appeared they are naturally diminished andsoftened. The overall result is a fresher and rejuvenated look. It canefficiently slow the dying and the loss of neurons, which is a naturallyoccurring process, the rate of which increases with aging.In turn the neuronal functioning of the brain is significantly improved and therisk of disease of the nervous system is reduced through the intake ofsufficient amounts of Resveratrol. Put more simply, by taking resveratrolyour body can burn fat more actively creating a slimming effect, reduce bad287

cholesterol levels thus lowering high blood pressure, and regulate blood Normal is 100+sugar levels to provide extra energy. -------------------------------------Resveratrol, a compound in grapes, displays antioxidant and other positive Changes in the serum levelsproperties. In a study published in the Journal of Biological Chemistry, of lactate dehydrogenaseresearchers at the UT Health Science Center San Antonio describe a novel have been noted to reflectway in which resveratrol exerts these beneficial health effects. growth and/or regression in many patients with testicularResveratrol stimulates the expression of adiponectin, a hormone derived tumors, but they werefrom cells that manufacture and store fat, the team found. Adiponectin has nonspecific.a wide range of beneficial effects on obesity-related medical complications,said senior author Feng Liu, Ph.D., professor of pharmacology and member However, elevation of theof the Barshop Institute of Longevity and Aging Studies at the Health first of the LDH isoenzymesScience Center. (LD-1) has been found specific to testicular cancerBoth adiponectin and resveratrol display anti-obesity, anti-insulin resistance among all neoplasms. Itand anti-aging properties. appears that elevation of serum LD-1 provides a“Results from these studies should be of interest to those who are obese, marker for seminoma and adiabetic and growing older,” Dr. Liu said. “The findings should also provide marker with some specificityimportant information on the development of novel therapeutic drugs for the for testicular cancer.200treatment of these diseases.”436; 437; 438 ===================== ===========================oOo========================== NAD Energy = Ratio of Lactate to Glucose Michelle's Macaroni n Cheese19 Thyroid Disorders Average NAD Level 66 Michelle Leigh Normal is 100+------------------------------------------------------------------------------------------------- ------------------------------------- Michelle Leigh Interests: Motorbikes, Having a good S.A. The pyruvate and lactate Braai, Family, Friends and levels in blood of patients anything sports related. I plan with thyroid diseases were to turn pro one day after investigated and also the studying. Interested in sport lactate/pyruvate ratio. The psychology & biokinetics. levels of pyruvate were Gauteng's current number one significantly elevated in golfer, won the RJ&K Ladies hyperthyreotic patients in Championships played on the comparison with the 1st and 2nd July 2011. euthyreotic control group; in hypothyreotic patients theMichelle has been playing excellent golf of late and certainly deserves her levels were lowered. Only innumber one position in Gauteng. Michelle is one of SA’s leading lady hypothyreotic patients theamateurs, who is currently ranked 15th in the country. lactate level was slightly increased.Ingredients: In all the three groups the1 Grated Gouda/Cheddar Cheese lactate/pyruvate ratio• 500g Macaroni showed highly significant• 250g Bacon differences, in• 200g Mushrooms hyperthyreosis decreased, in• White Flour hypothyreosis increased in• 250g Butter• Milk• Salt and Pepper• NutmegMethod:1 Add Salt to some boiling water, then add your 500g of macaroni to the pot2 Add your bacon to a hot olive oil coated pan, to this add your 200g mushrooms that have been sliced.3 When your bacon and mushrooms are almost cooked, drain them off and place on a piece of paper towel.4 Add approx. 200g butter, and when melted add flour and mix in until all288

the butter is absorbed. comparison with normal5 Once the flour has coated all your butter, add your milk and stir it around subjects. In patients suffering from until it starts to thicken. hyperthyreosis as well as in6 Drain your pasta when it is Al Dente, rinse off with some water to cases with euthyreotic goitre we found similar pyruvate prevent starch build up. levels and lactate/pyruvate7 When your sauce starts to thicken, add your grated cheese till sauce is ratios as in the hyperthyreotic cases. It thick and cheesy, add salt pepper and nutmeg to taste. seems likely to be an8 When your sauce is at your desired thickness add your mushrooms and inexpected effect of the treatment with pure bacon and add it to your pasta, mix the sauce in and serve hot. triiodothyronine or triiodothyronine/thyroxine in===========================oOo========================== combination.201 Rose Hips ===================== NAD Energy = Ratio of MIO Smoothie Ingredient Lactate to Glucose------------------------------------- ------------------------------------------------------------ Tourette's Syndrome Average NAD Level 75 Flowers are a beautiful part of Normal is 100+ our world, but new developments in medical ------------------------------------- science has taken flowers, weeds and other plants from Functional coupling of the fields and put them on the regional cerebral metabolic drugstore shelves in the form rates for glucose measured of nutritional supplements. with [18F]-Fluoro-2-deoxy- Many health benefits, D-glucose PET was probably known years ago to compared in 18 drug-free our ancestors, are being patients with Tourette's rediscovered, replacing some Syndrome (TS) and 16 age-of the current prescription drugs. and sex-matched control subjects.Rose hips are taken by many today as a natural way to get vitamin C,vitamin E and vitamin K, and help to prevent and treat various infections, Significant differencesespecially colds and flu. Rose hips are also taken to quicken the healing between Z-transformedprocess for bruises and skin irritations. Inflammation and sore throat can correlation coefficients werefind relief with rose hips. used to identify group differences, and revealedAs a matter of fact, rose hips provide innumerable health benefits from skin, that the connectivity of theto the immune system, to the bladder. Studies have even shown that rose ventral striatum was mosthips can help prevent the development of kidney stones and prevent severely affected in TS.diarrhea. Additional studies have proven rose hips are helpful to the Changes in the coupling ofcirculatory system, respiratory system, the thymus gland and as a blood other brain areas-primarycleanser. motor areas, somatosensory association areas, andOther health benefits include lowering abnormal body heat, relieving thirst, insula-also appeared tohealing of internal hemorrhaging or spitting of blood, aid for dysentery, differentiate TS patients andstrengthens the stomach, prevents and helps relief chest infections and controls.202coughs, cleans the kidneys and bladder, prevents fluid retention, helps withgout and rheumatic conditions and nourishes the skin.436; 437; 438 ===================== ====================== =====oOo============== ============ Michiel's Oxtail13 Michiel Bothma -------------------------------------- -------------------------------------- ---------------------289

Michiel Frederick Bothma is NAD Energy = Ratio of a South African professional Lactate to Glucose golfer. Bothma was born in Pretoria. He turned ------------------------------------- professional in 1993 and has played predominantly on the The Scotland Men’s Elite Southern Africa Sunshine Squad arrived at the Al Tour. He won for the firsttime Badia Golf Club in Dubai in 2002 at the Telkom PGA Festival City last week to Championship, one of the begin the first stint of their most prestigious warm weather training – Tournaments in South Africa. Scottish Amateur Champion In 2010 he won the Telkom Michael Stewart provides the PGA Championship for the first report from the camp. second time. The first week has been veryEleven years after his compatriot Trevor Immelman won the event, South busy and the boys haveAfrican Michiel Bothma triumphed at the 2011 Barclays Kenya Open to been raring to go eachcapture his first Challenge Tour title. His victory by two shots from fellow morning with our 6.30amSouth African Tyrone Ferreira was sweet relief for Bothma, who had won starts. The first thing we dopreviously on his native Sunshine Tour but never in five seasons on the is tests with the ScottishChallenge Tour.362 Institute of Sport physiologists. These consistMy Interpretation of Michiel Bothma's Favourite Meal - Oxtail Cavatelli363 of blood samples, weight checks, glucose and lactateIngredients: 8 Servings levels and they measure how well we have recoveredBraised Oxtail: from the previous day.203• 2 pounds oxtail• Salt and pepper, to taste =====================• 2 Tablespoons olive oil NAD Energy = Ratio of• 1 large onion, chopped Lactate to Glucose• 1 large carrot, chopped Trichotillomania Syndrome• 1 rib celery, chopped Average NAD Level 42• ½ head garlic Normal is 100+• 1/4 gallon chicken stock -------------------------------------Butternut Squash Dice:• 3 Tablespoons canola oil Positron emission• ½ cup butternut squash, diced tomography and• Salt, to taste 18-F-fluorodeoxyglucose were used to study restingMushroom Stock: cerebral glucose metabolism• ¼ pound Porcini mushrooms, dried in 10 adult women with• 1 quart water, filtered trichotillomania and 20 age-matched femaleCavatelli Sauce: controls.• 3 cups mushroom stock• 1 cup oxtail braising liquidCavatelli Pasta:• 1 Tablespoon duck fat• 2 egg yolks• 4 cups extra fine Semolina flour• 1 teaspoon salt• 1 cup waterAdditional:• 2 cups fancy mushrooms, sliced thick• 3 Tablespoons white truffle butter• ½ cup parmesan grated cheese• 1 teaspoon minced shallot• 1/8 cup chopped chives290

• 1 teaspoon chopped garlic As a group, the patients with• 1 Tablespoon butter trichotillomania showed significantly increased globalMethod: (mean gray matter) and normalized right and leftFor Braised Oxtail: cerebellar and right superior1. Pre-heat oven to 350°F. parietal glucose metabolic2. Season the oxtails liberally with salt and pepper. Heat 1 Tablespoon of rates. the olive oil in a large roasting pan and sear each side of each oxtail. Contrary to expectation, this Remove from heat, and trim any excess fat. Heat the remaining olive oil pattern differed from that and sauté the vegetables until they caramelize, approximately 5 seen in our previous minutes. Return the meat to the pan, and add the chicken stock. Bring investigation of to a boil, cover the pan, and place it in the oven for 3 hours. Remove the obsessive-compulsive cover and cook for an additional 30 minutes. Remove from heat and disorder. Clomipramine allow to cool. Pick the meat from the bones and set aside. Strain the hydrochloride-induced liquid and reserve. improvement was negatively correlated with anteriorFor Butternut Squash Dice: cingulate and orbital frontal1 Heat the oil in a sauté pan over high heat. Add the butternut squash and metabolism, of particular interest because similar sauté until golden brown. Stir the squash minimally as it caramelizes to results had been obtained retain texture. Remove squash from the pan and allow it to dry on paper for obsessive-compulsive towels. Season with salt and set aside. disorder.204For Mushroom Stock: =====================1 Place mushrooms and water in pot and bring to a boil. Lower the heat NAD Energy = Ratio of Lactate to Glucose and allow the stock to steep for 45 minutes. Strain through a chinois and Turner's Syndrome allow to cool; set aside. Average NAD Level 48 Normal is 100+For Cavatelli Sauce:1 Combine the liquids in a small sauce pot and bring to a boil. Remove ------------------------------------- from heat and strain liquid through a chinois. Allow the sauce to cool in Turner's syndrome is an ice bath. associated with glucose intolerance, diminishedFor Cavatelli Pasta: first-phase insulin response,1 Mix the duck fat and egg yolks together, blending until smooth. Add the elevated blood pressure, reduced FFM, and physical dry ingredients and mix until well incorporated. Add the water and blend fitness. until smooth. Allow the dough to rest for 1 hour, then roll it out on a dry, lightly floured surface to ¾-inch thickness. Cut the dough into ½-inch Sex hormone administration wide strips, and roll it through a cavatelli pasta maker, according to the causes a deterioration in manufacturer’s instructions. glucose tolerance, increases2 Cook the cavatelli in a large pot of salted boiling water for 4 minutes. FFM and physical fitness, Strain and immediately shock the pasta in an ice bath. When the pasta and has beneficial effects on has cooled, remove it from the ice water and allow to dry. blood pressure. The deleterious effect on glucoseTo Assemble and Serve: tolerance may be mediated1 Heat the butter in a large pan, and brown the mushrooms over high by norethisterone, a gestagen known to have heat. Add the shallots and garlic and sauté until fragrant. Reduce the heat to medium and add the picked oxtail meat, squash, 1 quart of cavatelli pasta, and 4 cups of cavatelli sauce. Reduce the mixture until the sauce is noticeably clinging to the pasta. Add the truffle butter and parmesan cheese. Adjust the seasoning of salt and pepper, to taste.2 Divide the pasta among heated serving plates. Garnish each dish with chives and serve immediately.===========================oOo========================== Rosemary MIO Smoothie Ingredient------------------------------------- ------------------------------------------------------------291

Charming rosemary herb is androgenic effects.205 the perfect potherb to have in your kitchen garden. The ===================== plant is one of the recognized NAD Energy = Ratio of herbs for its note-worthy Lactate to Glucose health benefiting Traumatic Brain Injuries phyto-nutrients, anti-oxidants, and essential acids. Apart ------------------------------------- from culinary and medicinal purpose rosemary shoots, At 6 months after traumatic flowers and leaves are used brain injury, there was a in ceremonies such as mean frontal lobe atrophy ofweddings and festivals for decorating banquet halls as incense to ward off 12 +/- 11% and global brainbad influences. atrophy of 8.5 +/- 4.5%. The percentage of time ofRosemary leaves contain certain phyto-chemical (plant derived) elevated lactate/pyruvatecompounds that are known to have disease preventing and health ratio correlated with thepromoting properties. The herb parts especially flower tops contain extent of frontal lobe brainphenolic anti-oxidant rosmarinic acid as well as numerous health benefiting atrophy (r = -.56, p < 0.01),volatile essential oils such as cineol, camphene, borneol, bornyl acetate, but not global brain atrophya-pinene etc. These compounds are known to have rubefacient (counter (r = -.31, p = 0.20). Theirritant), anti-inflammatory, anti-allergic, anti-fungal and anti-septic predictive effect ofproperties. lactate/pyruvate ratio was independent of patient age,The herb is exceptionally rich in many B-complex group of vitamin, such as Glasgow Coma Scale score,folic acid, pantothenic acid, pyridoxine, riboflavin. It is one of the herbs and volume of frontal lobecontain high levels of folates; providing about 109 mcg per 100 g (about contusion.27% of RDA). Folates are important in DNA synthesis and when givenduring peri-conception period can help prevent neural tube defects in the Persistent metabolic crisis,newborn babies. as reflected by an elevated lactate/pyruvate ratio, inFresh rosemary leaves are good source of antioxidant vitamin; vitamin-C normal appearingcontaining about 22 mg per 100 g, about 37% of RDA. It is required for the posttraumatic frontal lobe, iscollagen synthesis in the body. Collagen is the main structural protein in the predictive of the degree ofbody required for maintaining the integrity of blood vessels, skin, organs, tissue atrophy at 6and bones.436; 437; 438 months.206 ===========================oOo========================== ===================== NAD Energy = Ratio of Niclas' Salmon Burger13 Lactate to Glucose Biochemical Predictors Niclas Fasth of Mortality------------------------------------------------------------------------------------------------- ------------------------------------- Niclas Fasth is a Swedish professional golfer. Fasth was Early assessment of injury born in Gothenburg. He turned severity is important in professional in 1993 and won trauma. Trauma scores are three events on the second tier European Challenge Tour that year. Since 1994 he has been a member of the European Tour for every season except for 1999. He qualified for the U.S. based PGA Tour at the 1997 Qualifying School, and played the PGA and European Tours concurrently in 1998. He had a bad season on both and in1999 found himself back on the Challenge Tour.Since then he has concentrated on playing in Europe and in 2001, hefinished tenth on the European Order of Merit. He also finished second toDavid Duval in the 2001 Open Championship which enabled Fasth toqualify for the 2002 Ryder Cup.He had good seasons in 2005 and 2006, winning twice on the European292

Tour in both years and finishing thirteenth and fifteenth on the Order of calculated after the fact andMerit. In 2007, he finished fourth in the U.S. Open and the week after, he are useful for audit andwon his sixth European Tour event, the BMW International Open. These research, but not in theperformances helped Fasth to a fifth place finish on the Order of Merit. emergency clinical setting. Glucose metabolism isFasth has featured in the top 20 of the Official World Golf Rankings. altered in trauma, and wePerhaps best known for his achievement of jumping 60 spots in the official hypothesised that alterationsworld golf rankings in one go, Niclas Fasth has a career any professional in glucose and lactate levelsgolfer would be proud of.364 would be an early predictor of mortality.My Interpretation of Niclas Fasth's Favourite Meal - Salmon Burgers WithDill Cream Cheese Topping365 There was a significant correlation between gluc,Ingredients: Servings: 4 ISS, and TRISS (p 0.01), as well as lactate and ISS (pDill Cream Cheese Topping 0.01). Glucose and lactate• 3 ounces cream cheese, softened can predict mortality in• 2 tablespoons thinly sliced green onions severe trauma. The• 1 tablespoon prepared horseradish predictive value of glucose is• 1/2 teaspoon grated lemon peel comparable to that of ISS,• 1/4 cup sour cream and can be more easily• 1 teaspoon dill weed employed in the clinical setting.207Salmon Burgers• 1 lb salmon fillet, skin removed, cut into 1-inch pieces =====================• 4 everything bagels, seeded kaiser rolls or 4 seeded hamburger buns NAD Energy = Ratio of• 1 tablespoon drained capers, chopped Lactate to Glucose• 1/4 teaspoon black pepper, coarse grind• 1/2 teaspoon chili pepper, chipotle -------------------------------------• 1 tablespoon grated lemon peel• 2 tablespoons minced red onions It has become a somewhat• 1/3 cup panko bread crumbs common practice for• 1/2 teaspoon sicilian sea salt intermediate to elite athletes• 1 teaspoon garlic powder to have regular lactate• 1 egg, beaten assessments in an effort to• 1 teaspoon dill weed track improvements and to• 1 tablespoon oil determine and periodically assess training zones.Directions: These are both worthwhile ways to use the data from aFor the Dill Cream Cheese Topping: lactate test.2081 Mix all ingredients in small bowl until well blended;cover & refrigerate ===================== until ready to serve. NAD Energy = Ratio of Lactate to GlucoseFor the Salmon Burgers:2. Place salmon in food processor & cover; pulse until coarsely chopped, ------------------------------------- scraping down sides. (Do not over process salmon.) Blood lactate measurement3. Place salmon in large bowl. is an important tool in the4. Add egg, panko, onion, capers, lemon peel, dill weed, garlic powder, evaluation of human performance. Rising and chile pepper, sea salt and pepper. falling blood lactate levels5. Mix until well blended & shape into 4 patties.6. Heat oil in large nonstick skillet on medium heat.7. Add salmon patties; cook 4 to 5 minutes per side or until lightly browned and cooked through.8. Serve salmon burgers on bagels or rolls, if desired.9. Top with Dill Cream Cheese Topping.Salmon patties can be prepared 6 hours ahead. Place in single layer onbaking sheet. Cover with plastic wrap and refrigerate.===========================oOo========================== Rutin MIO Smoothie Ingredient------------------------------------- ------------------------------------------------------------293

Rutin is the basis of a whole can be a direct indicator of group of bioflavonoids that oxygen supply to muscles also includes hesperidin, during and after exercise or quercetin, eriodictyl and citron, training activities. and is essential for the absorption of vitamin C. Lactate data can help Although it is typically found in trainers evaluate an athlete's highly nutritious foods, such as fitness and susequently help citrus, red apples, teas, to monitor and modify broccoli and onions, etc., Rutin individual training can be easily found in programs.209 supplement form as well.Since the human body cannot manufacture bioflavonoids, and we should =====================supply them to make the most of our health, they must be derived through NAD Energy = Ratio ofdietary sources. They have been proven effective in enhancing and Lactate to Glucoseincreasing vitamin C's efficacy, improving eye health, strengthening fragilecapillaries, reducing cholesterol, improving blood circulation and functioning -------------------------------------as antioxidants. Recent studies indicate that bioflavonoids may pay a hugerole in protecting the body against invasive attack and serious illness. Your lactate profile is a powerful and reliableRutin is known to provide nutritional support to the circulatory systems predictor of performance inincluding the capillaries in eyes, and is especially beneficial in preventing aerobic exercise. The bodyrecurrent bleeding caused by weakened blood vessels. Rutin can also be produces a performance-utilized in the treatment of chronic venous insufficiency, glaucoma, hay limiting substance calledfever, hemorrhoids, varicose veins, poor circulation, oral herpes, cirrhosis, lactate during exercise. Thestress, low serum calcium, and for cataracts. Rutin is used systemically but lactate profile testalso topically in creams and ointments that are applied to stimulate blood determines the level ofcirculation and reduce capillary fragility in the body extremities. exercise intensity at which the body begins to produceRutin is considered to be a highly beneficial nutritional supplement because this substance at a greaterof its ability to strengthen capillaries, thus helping reduce the symptoms of rate than it can be removed.people suffering from arteriosclerosis (the hardening of the arteries), highblood pressure or venous insufficiency. Rutin is a member of a group of Knowing your lactate profileplant compounds called bioflavonoids that also include the important will allow you to plan yourcatechins of green tea and the polyphenols of red wine. Recent studies training, raise your lactatehave demonstrated and proven that the bioflavonoids are powerful threshold and increase yourantioxidants that fight free radicals. Free radicals are said to be responsible work intensity.210for as much as 9 out of 10 of all the human diseases such as cancer,arteriosclerosis, strokes, senility due to aging, etc.Current research claims that Rutin supplements may lead to healthycholesterol levels in the blood, thus stimulating good circulation andpossibly minimizing the risks of hypertension. Additionally, Rutin is said toinhibit platelet aggregation, which may also help to improve bloodcirculation. It is also believed to lower the cytotoxicity of oxidized LDLcholesterol, which in turn lowers a person’s susceptibility to heart disease.Rutin (just like all bioflavonoids) is used on a large scale in the treatment ofathletic injuries, because bioflavonoids have been shown effective inrelieving the pain of bumps and bruises, located in the legs or across theback (which are the common areas or sites of injury among athletes).436; 437;438===========================oOo========================== ===================== NAD Energy = Ratio of Chef Nicholas' Creamy Potato Leek Soup Lactate to Glucose Chef Nicholas Sanchez - Stockton Golf & Country Club -------------------------------------------------------------------------------------------------------------------------------------- Pyruvate + NADH + H+ <=> Lactate + NAD+ 294 This reaction is so rapid that pyruvate and lactate can be considered to be always in an equilibrium situation.

Of the 200-plus recipes for Normally the ratio of lactate which Executive Chef to pyruvate in the cell is 10 Nicolas “Nico” Sanchez has to 1. become regionally renowned at Stockton The ratio [NADH]/[NAD+] by (Calif.) Country Club, no the Law of Mass Action kitchen concoction can determines the balance match his recipe for between lactate and adaptation, passion and pyruvate. This ratio is also perseverance in the United used to denote the redox States. state within the cytoplasm.211Sanchez — who maintains an 18 handicap but admits “I don’t have enough =====================time to play as much golf as I would like” — has cooked for Jack Nicklaus, NAD Energy = Ratio offormer Vice President Dick Cheney, the Stockton Chamber of Commerce, Lactate to Glucosethe Northern California PGA Section board and members, and for virtuallyevery community and charity organization in the Stockton area. But, day in -------------------------------------and day out, he says there is nothing more gratifying than cooking for themembers at Stockton Country Club.366 Golf is a hard game to play, at least to play properly, andIngredients: Yield: 4-6 1 cup portions367 you have to be prepared• 2 pounds russet potatoes, peeled and diced into ½ inch cubes before you start your round• 2 cups chicken / vegetable broth in the same way that any• 2 tablespoons butter other sportsman needs to be• 2 cups water prepared.• 1 ½ cups heavy cream• 3 large leeks Energy is generated in your• Salt and pepper to taste body by means of blood• Marjoram, pinch glucose being metabolised• Tabasco or red chili sauce in the mitochondria of your body cells into energy. ThatTo Prepare glucose can come from1 In a medium saucepan, sauté leeks at medium high until tender. many sources, though it is produced in the body from Reduce heat to low and cover. Continue to cook for 10 minutes. Add a fats, carbohydrates and pinch of salt and pepper. sugars.2122 Add water, broth and potatoes to the pan. Bring to a low simmer and cook for 20 minutes. =====================3 Remove about half of the soup and place in a blender or food NAD Energy = Ratio of processor. Puree until smooth. Lactate to Glucose4 Return the puree to the pan and add cream.5 Bring heat to medium high and simmer for 10 to 15 minutes. -------------------------------------6 Add a dash of red chili sauce to taste. Golf is a sport that requires7 Garnish with a pinch of dry marjoram. optimal levels of concentration over periods===========================oOo========================== of time up to five hours. Bearing in mind the technical S Hydroxy Tryptophane specificity required to reproduce a sound golf MIO Smoothie Ingredient swing time after time,------------------------------------- ------------------------------------------------------------ nutritional preparation forTryptophan (L- Tryptophan) is an essential amino acid made from proteinsduring digestion by the action of proteolytic enzymes. Being an essentialamino acid, Tryptophan can only be obtained through food and cannot beproduced within the body. Essential amino acids must be derivedpreformed from food or supplements; non-essential aminos on the otherhand can be made from the essential amino acids, or other non-essentialamino acids. Many naturally occurring physiological substances are derivedfrom L-Tryptophan such as serotonin (after being converted into 5-HTP),which is involved in vasopressure regulation, and indolacetic acid, which isa plant hormone and also involved in elevated blood pressure, ergotamine,strychnine and other indole alkaloids. Serotonin is also involved in mood,appetite, sleep, and impulse control, owing to the fact that it is a potentneurotransmitter in the brain.295

This makes Tryptophan a participation in golf deserves precursor and a vital element for attention. neurotransmitters serotonin (a neurotransmitter) and melatonin Depriving the brain of (a neurohormone). These sufficient nutrients will chemical messengers transport negatively affect decision nerve impulses from one cell to making on the golf course - another. Put in simpler terms, for example, shot selection our brain can not function and course management properly without sufficient would be compromised amounts of these under these conditions. The neurotransmitters. When brain functions exclusivelycarbohydrates are consumed, an increase in insulin in the body increases, on glucose, which is awhich in turn removes other amino acids that compete with tryptophan. This substrate in the human bodymakes it easier for tryptophan to enter the brain to manufacture serotonin, responsible for providingwhich affects the brain function in regulating food intake and sleep patterns. energy and is mainly derivedStudies have shown that a deficiency in serotonin levels can lead to from carbohydratesdepression and insomnia and both these conditions are aggravated as (CHD’s).213serotonin levels decrease. =====================Tryptophan may enhance relaxation and sleep, relieve minor premenstrual NAD Energy = Ratio ofsymptoms, soothe nerves and anxiety, and reduce carbohydrate cravings. Lactate to GlucoseTryptophan is crucial to produce serotonin. Serotonin is one of the key brainchemicals involved in regulating mood. During depression, there is a -------------------------------------decreased amount of serotonin released from nerve cells in the brain. Byincreasing the amount of serotonin in the blood, tryptophan may increase However, in practice itserotonin’s antidepressant effects. Tryptophan is only used during therapy seems that most golfers payin conjunction with other antidepressants. little attention to what they eat. Golfers differ from otherSerotonin plays an important role in controlling appetite and managing sportspeople in this respect,weight loss. In response to high carbohydrate meals, more serotonin is because other sportsreleased, which is thought to decrease appetite and improve mood. enthusiasts have alreadyTryptophan is also involved in the body’s regulation of sleep. Increasing discovered that changingtryptophan can also assist in normalizing sleep patterns. Studies have also their eating habits canfound that people who suffer from migraine headaches have abnormal dramatically improve theirlevels of tryptophan, and in this supplementation may be helpful. performance.If you have insomnia, tryptophan may be beneficial as well. Several In other words, healthyresearch studies have demonstrated L-tryptophan to be helpful in the well-timed snacks delivertreatment of chronic insomnia at doses of between one to four grams immediate benefits for bothbefore bedtime. Additionally, L-tryptophan is not associated with side professional and amateureffects that are common with prescription drugs, nor does it cause golfers. So choose productsdrowsiness or difficulty in getting up the next day. This makes L-tryptophan you plan to consume on thea viable and attractive option to conventional drug therapies for the course carefully, becausetreatment of chronic insomnia.436; 437; 438 the difference between a hole in one or a bunker ===========================oOo========================== disaster often has more to do with nutrition than many Nicole's Bruschetta Chicken19 golfers think.214 Nicole Forshner =====================------------------------------------------------------------------------------------------------- NAD Energy = Ratio ofMy all-time four ball group would include, Nancy Lopez, Arnold Palmer andGary Player. My proudest moment would be winning my secondconsecutive provincial amateur with my family watching. My favouritecourse is my home club in Canada, the Banff Springs Golf Club.296

I always have an ipod in my bag Lactate to Glucosewith a portable speaker system -------------------------------------to blast tunes when I'm havinga relaxed round with friends.My best tip is to not takeanything too seriously.Ingredients: Yield: 4 servings Their ability to learn new• 4 boneless chicken breast halves skills for golf is certain and• 1/4 cup grated parmesan cheese can bring great rewards, but• 3 tablespoons minced fresh basil they must be ready for some• 1 tablespoon melted butter discomfort as they \"build• 2 cloves of garlic, minced new neurons\" that help them• 2 eggs lightly beaten replace old habits (neural• 1/4 cup bread crumbs pathways) with great new• 1 tablespoon olive oil ones.• 1/4 teaspoon pepper• 1/2 cup flour And it requires energy to• 1/2 teaspoon salt make learning stick! The• 2 large tomatoes brain must use glucose to move information fromMethod: \"working memory\" to the1. Place flour and eggs in separate shallow bowls. basal ganglia at the base of2. Dip chicken in flour, then in eggs; place in a greased 13 in. x 9 in. x 2 in. the brain. baking dish. Research shows that3. Combine Parmesan cheese, bread crumbs, and butter; sprinkle over making just one decision reduces the glucose-blood chicken. sugar-available for the next4. Loosely cover baking dish with foil. decision, says David Rock,5. Bake at 375 degrees for 20 min. founder and chief executive6. Uncover; bake 5-10 minutes longer or until top is browned. officer of Results Coaching7. Meanwhile, in a bowl, combine, the remaining ingredients. Systems in New York.8. Spoon over the chicken.9. Return to the oven for 3-5 minutes or until tomato mixture is heated This explains why a lot of players, when energy levels through. are low, are inclined to simply revert back to the old===========================oOo========================== habits ingrained in their basal ganglia part of the Sage brain.215 MIO Smoothie Ingredient =====================------------------------------------- ------------------------------------------------------------ NAD Energy = Ratio of Lactate to Glucose Sharply flavored, sage herb or garden sage is one of the ------------------------------------- popular pot herbs known since ancient Roman times. This Fitness for golf is not only legendary herb with numerous being supple and strong: it is virtues, long held to be guardian knowing how to eat for golf over all other herbs, has been in so that you get through your use in various traditional golf round without losing European and Chinese your strength and finishing medicines for its health on a low after a great start. It promoting and disease happens to all of us, yet we preventing properties. Sageherb parts have many notable plant derived chemical compounds, essentialoils, minerals, vitamins that are known to have disease preventing andhealth promoting properties.The primary biologically active component of common sage appears to beits essential oil which contains mainly ketone a- and ß-thujone. In addition,sage leaf contains numerous other substances including cineol, borneol,tannic acid; bitter substances with cornsole and cornsolic acid; fumaric,chlorogenic, caffeic and nicotinic acids; nicotinamide; flavones; flavone297

glycosides; and estrogenic substances. These compounds are known to frequently wonder why wehave counter-irritent, rubefacient, anti-inflammatory, anti-allergic, anti-fungal suddenly start to go downhilland anti-septic properties. after the twelfth hole or so.Thujone is GABA and Serotonin (5-HT3) receptor antagonist. It enhances You might think that you areconcentration, attention span and quickens the senses; hence sage getting a bit older, or areinfusion has long been recognised as \"thinker's tea\". Its effects help deal unfit due to a lack of trainingwith grief and depression. or practice, but what that does is to reduce yourThee lobe sage (S. triloba) has flavone called salvigenin. Research studies ability, not your endurance.found that vascular relaxant effect of salvigenin may provide benefits in the Many confuse endurance orcardiovascular diseases. stamina with fitness, and while there is certainly anThis herb is exceptionally very rich source of many B-complex groups of element of fitness andvitamins, such as folic acid, thiamin, pyridoxine and riboflavin with many training in stamina, nobodyvitamins several times more than recommended levels 436; 437; 438 can maintain peak strength and lasting power without ===========================oOo========================== proper nutrition. It is the glucose levels in your blood Patrick's Steak Dinner19 that determine your lasting power.216 Patrick McLaughlin------------------------------------------------------------------------------------------------- ===================== NAD Energy = Ratio of Patrick Mc Laughlin Started Lactate to Glucose caddying @ 11 yrs, eldest of 10 children, 9 boys 1 girl, loved ------------------------------------- golf from early age as my dad was a fine player, left school to Many aspects of the work @ 15, worked in pro shop physicality of golf have been for summer, got offered a pro discussed and researched, job in states @ 17, refused as with good reason. However, a bit of home boy, went to work golf is as much a mental in England when I was game as it is a physical 20,stopped golf for 3 yrs, came game. The brain will usehome played again but was never as good as I was, represented my club 15% of the circulating@ senior level for last 20 yrs, won all Ireland medal in'05, have 4 kids glucose (sugar) in the bloodmyself and none are interested in golf, lol my dream would be to play pro while at rest. This is agolf, maybe the senior tour in 6 yrs lol significant amount considering how small theMy favorite recipe for dinner is Steak (well done) saute potatoes and turnip brain is compared to all theand bisto gravy, large muscles in the body.I'm Irish so fairly bland in comparison. This glucose usage may increase by 100-150% whenMy Interpretation of Patrick McLaughlin's Favourite Meal - Irish Steak372 the brain is very active. Poor glucose supply causesIngredients: sluggishness, poor• 1 12-oz. New York strip concentration, slow reaction,• Cracked black peppercorns and altered communication• 2 T. butter with the body. This will lead• 1 oz. Irish whiskey to a decrease in• 1/4 C. heavy whipping cream• Fresh chopped parsleyHow to make it1 Coat both sides of steak with crushed peppercorns.2 Melt butter in cast iron skillet.3 Place steak in pan and cook on one side for 6 minutes; turn and cook an additional 4 minutes for medium rare.4 Remove steak from pan and place on warm platter.5 Pour off butter; deglaze pan with whiskey.6 Set on fire. When flame goes out, continue to cook 1 minute.7 Add heavy cream and cook on high to reduce.8 When sauce thickens, add parsley and ladle onto steak.Ingredients for cooking an Irish meal with turnips373298

• Turnips – 1lb to serve 4 people performance, especially late• Butter – ¼ cup in a round when one's• Salt & black pepper muscles may be fatigued as well. That being said it isPreparing the turnips easy to see why keeping1 First wash and peel the turnips. energy during a round of golf2 Cut the turnips into small cubes. is important, not only3 Place the cubed turnips into a large pot of salted water and cook for physically but mentally as well.368 approx 20 minutes or until tender.4 When cooked drain the turnips. =====================5 Using a large frying pan melt the butter in the pan and then add the NAD Energy = Ratio of Lactate to Glucose cubed turnips.6 Cook the turnips for approx 5 – 10 minutes or until a golden color. -------------------------------------===========================oOo========================== Golf is a game of multiple short bursts of high-intensity Schisandra Extract activity combined with long periods of low energy level MIO Smoothie Ingredient standing, walking and sitting------------------------------------- ------------------------------------------------------------ in a cart. It’s the relatively long duration (over 4 hours) Besides having a memorable if of needed physical and strange taste, schizandra has mental sharpness that made a big impression in the requires the body and brain scientific community, as to be operating optimally. numerous studies demonstrate its potent health benefits. Schizandra chinensis enjoys millennia of traditional use for prolong life, retarding the aging process, increasing energy, as a fatigue-fighter, and as a sexual tonic. Schizandra alsopossesses significant protective antioxidant and anti-inflammatory activity.Thus it helps to maintain healthy cells throughout the body. It is consideredone of the most highly protective of all medicinal plants, and the berry isincluded in many traditional herbal formulas for improving energy andmental health.Schizandra berry demonstrates significant adaptogenic activity. What doesthis mean? To qualify as an adaptogen, an herb must be completely safeand non-toxic, it must have broad uses for health, and it must specificallyreduce stress, both mental and physical. As an adaptogen, schizandra is apotent general tonic, decreasing fatigue, enhancing physical performance,and promoting endurance. The berry counters stress by reducing the levelsof stress hormones in the blood. Additionally, schizandra offers greatbenefits for athletes. In human studies schizandra berry and its extractshave improved performance among long distance runners, skiers andgymnasts. For this reason schizandra berry is often found on the trainingtables of Chinese athletesSchizandra also offers special benefits for the mind. Several human studiesshow that schizandra extract improves concentration, coordination andendurance. Schizandra helps to prevent mental fatigue and increasesaccuracy and quality of work. In various human clinical studies with doctors,students, soldiers and other groups, schizandra demonstrated superiormind-sharpening powers.436; 437; 438299

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